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<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="YEAST_metabolic_network_metabolic_network" name="Saccharomyces cerevisiae">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
  <species id="OXOHEX__45__2__45__ENEDIOATE" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="B__45__ALANINE" name="&amp;beta;-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADPH" name="NADPH" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__313" name="1,3-Diaminopropane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAMINE__45__5P" name="pyridoxamine 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__R__45__S__45__glutathione__124__" name="R-S-glutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FAD" name="FAD" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBON__45__MONOXIDE" name="carbon monoxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__deoxy__45__D__45__glucose__32__6__45__phosphate" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GAMMA__45__GLUTAMYLCYSTEINE" name="L-&amp;gamma;-glutamylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP" name="GDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" name="an L-1-phosphatidylglycerol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" name="an L-1-phosphatidyl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="APS" name="APS" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SEDOHEPTULOSE__45__7__45__P" name="sedoheptulose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROFOLATE" name="7,8-dihydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acceptor__124__" name="an oxidized electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__PG" name="2-phosphoglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ILE" name="L-iso-leucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINAMINE" name="S-adenosylmethioninamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARG" name="L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOHEME" name="protoheme" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__LYSOLECITHIN" name="L-1-lysolecithin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" name="5-phospho-ribosyl-glycineamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMALDEHYDE" name="formaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHTYOSPHINGOSINE__45__1__45__P" name="phytosphingosine-1-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMP" name="IMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIAMINONONANOATE" name="7,8-diaminononanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1079" name="L-2-Aminoadipate 6-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1072" name="4-vinylguaiacol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1789" name="dehydro-D-arabinono-1,4-lactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__COA" name="acetyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD1G__45__159" name="RX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNOSE" name="mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BUTANEDIOL" name="butanediol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HIS" name="L-histidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOLALDEHYDE" name="glycolaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" name="4-amino-4-deoxychorismate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD1G__45__160" name="HX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AN__32__O__45__GLUCOSYLSTEROL" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="COPROPORPHYRINOGEN_III" name="coproporphyrinogen III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__6" name="ubiquinone(30)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ASPARTATE" name="L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ASN" name="L-asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aryl__45__Aldehyde__124__" name="an aryl aldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HEXAPRENYL__45__DIPHOSPHATE" name="hexaprenyl-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1063" name="5-methylthioribulose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Donor__45__H2__124__" name="a reduced electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CYSTATHIONINE" name="cystathionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" name="L-&amp;Delta;1-pyrroline-5-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACRYLATE" name="acrylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" name="6,7-dimethyl-8-(1-D-ribityl)lumazine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL" name="pyridoxal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4702" name="4&amp;alpha;-carboxy-5&amp;alpha;-cholesta-8,24-dien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" name="1L-myo-Inositol 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TREHALOSE__45__6P" name="&amp;alpha;,&amp;alpha;-trehalose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FE__43__2" name="Fe2+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHE" name="L-phenylalanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEHYDROQUINATE" name="3-dehydroquinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IPC" name="inositol-P-ceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINOL__45__30" name="ubiquinol(30)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__5P" name="ribose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATP" name="ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="phospholipid" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD3O__45__409" name="Glc(2)Man(9)GlcNac(2)-PP-Dol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD3O__45__408" name="Glc(1)Man(9)GlcNAc(2)-PP-Dol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" name="D-erythro-imidazole-glycerol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Long__45__Chain__45__Polyphosphate__124__" name="long chain polyphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" name="phosphoribosylformiminoAICAR-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSE" name="&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DI__45__H__45__OROTATE" name="dihydroorotate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDRONEOPTERIN__45__P3" name="dihydroneopterin triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NAD" name="NAD" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD3O__45__410" name="Glc(3)Man(9)GlcNAc(2)-PP-Dol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8999" name="5-(methylthio)-2,3-dioxopentyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__MANNOSE" name="GDP-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH__45__P__45__OR__45__NOP" name="NAD(P)H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="T2__45__DECENOYL__45__COA" name="trans-&amp;Delta;2-decenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCEROL__45__3P" name="glycerol-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDPDIACYLGLYCEROL" name="a CDP-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__ATP" name="phosphoribosyl-ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__LACTATE" name="D-lactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRANS__45__D2__45__ENOYL__45__COA" name="a trans-2-enoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="URACIL" name="uracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" name="a 2,3,4-saturated fatty acyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__METHOXY__45__4__45__HYDROXY__45__5__45__HEXAPRENYLBENZOATE" name="3-methoxy-4-hydroxy-5-hexaprenylbenzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__250" name="L-Formylkynurenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8190" name="a phospholipid methylene fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__356" name="D-arabinono-1,4-lactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROKAEMPFEROL__45__CMPD" name="dihydrokaempferol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__3__45__HYDROXYACYL__45__COA" name="a (3S)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TYR" name="L-tyrosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SUC" name="succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HOMO__45__CYS" name="homocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" name="4,4-dimethyl-cholesta-8,14,24-trienol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THIAMINE" name="thiamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__249" name="a sulfur donor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHYTOCERAMIDE" name="phytoceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ISOBUTANAL" name="isobutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THREO__45__DS__45__ISO__45__CITRATE" name="isocitrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" name="3-deoxy-D-arabino-heptulosonate-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD3O__45__4104" name="3-methylbutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LYS" name="L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENYLOSUCC" name="adenylo-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1301" name="tetrahydropteroyltri-L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__341" name="indole-3-ethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1302" name="5-methyltetrahydropteroyltri-L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="NAD__45__P__45__OR__45__NOP" name="NAD(P)+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOPORPHYRIN_IX" name="protoporphyrin IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1107" name="D-myo-inositol (1,3,4,5,6)-pentakisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="amylose__40__n__45__1__41__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CITRULLINE" name="citrulline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Amino__45__Acids__45__20__124__" name="a standard &amp;alpha; amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="XYLITOL" name="xylitol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UROPORPHYRINOGEN__45__III" name="uroporphyrinogen-III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALDITOL" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CYANIDE" name="cyanide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__85" name="1,2-dihydroxy-3-keto-5-methylthiopentene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOGENN__45__1" name="Glycogen(N-1)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HSCN" name="thiocyanic acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="CPD3O__45__258" name="Man(9)GlcNAc(2)-PP-Dol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1113" name="D-Glucosaminylphosphatidylinositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="AMYL__45__ALCOHOL" name="amyl alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="N__45__ALPHA__45__ACETYLORNITHINE" name="N-&amp;alpha;-acetylornithine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHYLENE__45__THF" name="5,10-methylene-THF" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD3O__45__250" name="4- or 6-diphosphoinositol pentakisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GERANYLFARNESYL__45__DIPHOSPHATE" name="geranylfarnesyl-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="__124__Keto__45__Acid__124__" name="a keto acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="NADH" name="NADH" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="AICAR" name="AICAR" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__HEXAPRENYL__45__6__45__METHOXYPHENOL" name="2-hexaprenyl-6-methoxyphenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="_4__45__PHOSPHOPANTOTHENOYLCYSTEINE" name="4&apos;-phospho-N-pantothenoylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADP" name="NADP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Hexoses__124__" name="a D-hexose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="GLC" name="&amp;beta;-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="FORMYL__45__THF__45__GLU__45__N" name="an N10-formyl-tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="CPD__45__190" name="GlcNAc-PP-Dol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1002" name="p-cumic alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__192" name="1D-myo-Inositol 1,4-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HISTIDINAL" name="histidinal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__194" name="4-Nitrophenyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="CPD__45__479" name="2-oxo-4-methylthiobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="PYRIDOXAMINE" name="pyridoxamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="GLN" name="L-glutamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROFOLATE__45__GLU__45__N" name="a 7,8-dihydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Glycogens__124__" name="a glycogen" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PALMITALDEHYDE" name="palmitaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__KETO__45__2__45__METHYLVALERATE" name="2,3-dihydroxy-3-methylvalerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="A__32__STEROL" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PRPP" name="PRPP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLT" name="L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHITIN" name="chitin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="L__45__ALPHA__45__ALANINE" name="L-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMP" name="AMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ETOH" name="ethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UTP" name="UTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Alditols__124__" name="an alditol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLCNAC2PPDOL" name="GlcNAc(2)-PP-Dol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMATE" name="formate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__OH__45__BENZALDEHYDE" name="3-Hydroxybenzaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" name="a 1,4-&amp;alpha;-D-glucan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PRO" name="L-proline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__40__1__44__3__45__BETA__45__D__45__GLUCOSYL__41____40__N__41__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="DEOXYCYTIDINE" name="deoxycytidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUTP" name="dUTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FADH2" name="FADH2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="PHENYLACETALDEHYDE" name="phenylacetaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PANTETHEINE__45__P" name="pantetheine 4&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PSEUDOURIDINE__45__5__45__P" name="pseudouridine 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="DETHIOBIOTIN" name="dethiobiotin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__ACYLGLYCEROPHOSPHOCHOLINE" name="2-acylglycerophosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DPG" name="3-phospho-D-glyceroyl-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BIOTIN" name="biotin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CO__45__A" name="Coenzyme A" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE" name="S-adenosyl-4-methylthio-2-oxobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="THZ__45__P" name="4-methyl-5-(&amp;beta;-hydroxyethyl)thiazole phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="DGTP" name="deoxy-GTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENINE" name="adenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="DOLICHOLP" name="dolichol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" name="4,4-dimethylzymosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ZYMOSTEROL" name="zymosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="LANOSTEROL" name="lanosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="DATP" name="deoxy-ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="DCTP" name="dCTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" name="N-(5&apos;-phosphoribosyl)-anthranilate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
</listOfSpecies>
<listOfReactions>
  <reaction id="_1__45__PHOSPHATIDYLINOSITOL__45__KINASE__45__RXN" name="1-phosphatidylinositol 4-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LSB6 ) or ( PIK1 ) or ( STT4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( phosphatidylinositol 4-kinase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phosphatidylinositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.67</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__482" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHEAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase I )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ILV5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetohydroxyacid reductoisomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERPHOSPHA__45__RXN" name="Phosphoserine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SER2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine phosphatase )</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis from 3-phosphoglycerate</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINATE__45__DEHYDROGENASE__45__UBIQUINONE__45__RXN" name="Succinate dehydrogenase (ubiquinone)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( SDH3 and SDH4 and SDH1 and SDH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate dehydrogenase (ubiquinone) ) or ( succinate dehydrogenase iron-sulfur protein subunit and succinate dehydrogenase flavoprotein and succinate dehydrogenase cytochrome b and succinate dehydrogenase membrane anchor subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of TCA cycle and glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle, aerobic respiration</html:p>
<html:p>PROTEIN_CLASS: 1.3.5.1</html:p>
<html:p>COFACTOR: __124__Ubiquinols__124__</html:p>
<html:p>COFACTOR: __124__Ubiquinones__124__</html:p>
<html:p>SIDE: __124__Ubiquinols__124__</html:p>
<html:p>SIDE: __124__Ubiquinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDHDEHYDROG__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALD5 ) or ( ALD4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase (minor mitochondrial) ) or ( aldehyde dehydrogenase (major  mitochondrial) )</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATEMUT__45__RXN" name="Chorismate mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chorismate mutase )</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANOSINE__45__DIPHOSPHATASE__45__RXN" name="Guanosine-diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GDA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanosine diphosphatase of Golgi membrane )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.42</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATESYNTH__45__RXN" name="Dihydrofolate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FOL3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: folate biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16ALDOLASE__45__RXN" name="Fructose-bisphosphate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FBA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldolase )</html:p>
<html:p>SUBSYSTEM: glycolysis</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R15__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO8 ) or ( ARO9 ) or ( BAT2 ) or ( BAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase I ) or ( aromatic amino acid aminotransferase II ) or ( branched-chain amino acid transaminase ) or ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine salvage pathway</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.5</html:p>
<html:p>SIDE: __124__Keto__45__Acid__124__</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="__124__Keto__45__Acid__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7607" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ISN1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IMP-specific 5&apos;-nucleotidase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4141" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH2 ) or ( ADH4 ) or ( ADH5 ) or ( ADH3 ) or ( ADH1 ) or ( SFA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOBUTANAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOBUTYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRAISOM__45__RXN" name="Phosphoribosylanthranilate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TRP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-(5&apos;-phosphoribosyl)-anthranilate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.24</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENETHFDEHYDROG__45__NADP__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MIS1 ) or ( ADE3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mitochondrial C1-tetrahydrofolate synthase ) or ( C1-tetrahydrofolate synthase )</html:p>
<html:p>SUBSYSTEM: folate interconversions</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATE__45__TRANSAMINE__45__RXN" name="Aromatic amino acid transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO8 ) or ( ARO9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase I ) or ( aromatic amino acid aminotransferase II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__659" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSLIG__45__RXN" name="Phosphopantothenate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAB2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphopantothenate-cysteine ligase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__PHOSPHOPANTOTHENOYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__662" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AAD4 ) or ( AAD3 ) or ( AAD14 ) or ( AAD6 ) or ( AAD10 ) or ( AAD15 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1002" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1003" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZYL__45__ALC__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AAD4 ) or ( AAD3 ) or ( AAD14 ) or ( AAD6 ) or ( AAD10 ) or ( AAD15 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__DEHYDRATASE__45__RXN" name="3-dehydroquinate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUC__45__COA_TO_CO__45__A_COF_RXN" name="SUC-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__3" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc2:Man6:Man transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.130</html:p>
<html:p>SIDE: CPD__45__171</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__340" stoichiometry="1"/>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__2" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATE__45__SYNTHASE__45__RXN" name="Chorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chorismate synthase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.5</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLHOMOSER__45__CYS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET17 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-acetylhomoserine (thiol)-lyase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: homocysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.49</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4133" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC5 ) or ( PDC6 ) or ( PDC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase )</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.1</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOBUTANAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPYROPHOSPHAT__45__RXN" name="NAD+ pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NPY1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH pyrophosphatase 1 )</html:p>
<html:p>SUBSYSTEM: periplasmic NAD degradation</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NICOTINAMIDE_NUCLEOTIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_13__45__BETA__45__GLUCAN__45__SYNTHASE__45__RXN" name="1,3-beta-glucan synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FKS1 ) or ( FEN1 ) or ( GSC2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,3-beta-D-glucan synthase ) or ( 3-ketoacyl-CoA synthase ) or ( 1,3-beta-D-glucan synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.34</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__40__1__44__3__45__BETA__45__D__45__GLUCOSYL__41____40__N__41__" stoichiometry="1"/>
      <speciesReference species="__124__1__45__3__45__beta__45__D__45__Glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__40__1__44__3__45__BETA__45__D__45__GLUCOSYL__41____40__N__43__1__41__" stoichiometry="1"/>
      <speciesReference species="__124__1__45__3__45__beta__45__D__45__Glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__3__45__PHOSPHATE__45__DEHYDROGENASE__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GUT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTOCHROME__45__C__45__PEROXIDASE__45__RXN" name="Cytochrome-c peroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome c peroxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2363" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2361" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSE6PSYN__45__RXN" name="Alpha,alpha-trehalose-phosphate synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.15</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTEROATESYNTH__45__RXN" name="Dihydropteroate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FOL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: folate biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.15</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__AMINOTRANSFERASE__45__RXN" name="Tryptophan aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase I )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.27</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4135" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LRO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Lecithin cholesterol acyl transferase )</html:p>
<html:p>SUBSYSTEM: triglyceride biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.158</html:p>
<html:p>SIDE: lysophospholipid</html:p>
<html:p>SIDE: phospholipid</html:p>
<html:p>GENERIC: true</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="phospholipid" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="lysophospholipid" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__786" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DDP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diadenosine and diphosphoinositol polyphosphate phosphohydrolase )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.-.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__144" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__768" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGANINE__45__KINASE__45__RXN" name="DHS kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LCB4 ) or ( LCB5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.91</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__785" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DDP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diadenosine and diphosphoinositol polyphosphate phosphohydrolase )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.52</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__768" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSALDOL__45__RXN" name="Transaldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TAL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transaldolase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: non-oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__117__45__RXN" name="Dolichyl-phosphate beta-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose:dolichyl-phosphate glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: dolichyl glucosyl phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.117</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: DOLICHOLP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOLICHOL__45__KINASE__45__RXN" name="Dolichol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SEC59 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dolichol kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.108</html:p>
<html:p>COFACTOR: CDP</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__16__45__RXN" name="Methylene-fatty-acyl-phospholipid synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CHO2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.16</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHOLIPID__32__OLEFINIC__32__FATTY__32__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHOLIPID__32__METHYLENE__32__FATTY__32__ACID" stoichiometry="1"/>
      <speciesReference species="CPD__45__8190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP_TO_GDP_COF_RXN" name="GTP_TO_GDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCSEMIALDDEHYDROG__45__RXN" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: glutamate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__NITROPHENYLPHOSPHATASE__45__RXN" name="4-nitrophenylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PHO13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( p-nitrophenyl phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.41</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__194" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__581" name="inositol phosphoceramide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AUR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IPC synthase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: INOSITOL__45__PHOSPHATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__HYDROXYPHYTOCERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IPC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAICARSYN__45__RXN" name="Phosphoribosylaminoimidazole-succinocarboxamide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosyl amino imidazolesuccinocarbozamide synthetase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLFORMAMIDASE__45__RXN" name="Arylformamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BNA7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: de novo NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan degradation via kynurenine</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.9</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__250" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMYLOMALT__45__RXN" name="4-alpha-glucanotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GDB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucanotranferase )</html:p>
<html:p>SUBSYSTEM: glycogen catabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>SIDE: MALTOSE</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATPPHOSPHORIBOSYLTRANS__45__RXN" name="ATP phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.17</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__681" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MET7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthetase )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__680" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositolphosphotransferase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: INOSITOL__45__PHOSPHATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MIPC" stoichiometry="1"/>
      <speciesReference species="INOSITOL__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MIP2C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINE__45__NUCLEOSIDASE__45__RXN" name="Uridine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( URH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R314__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AMD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM2__45__RXN" name="Cytidine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CDD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTODEXGLUCOSID__45__RXN" name="Alpha-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( MAL32 ) or ( MAL12 ) or ( NA ) or ( NA ) or ( FSP2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha glucosidase ) or ( maltase ) or ( maltase ) or ( alpha glucosidase ) or ( alpha glucosidase ) or ( alpha-D-glucosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="amylose__40__n__45__1__41__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BAT2 ) or ( BAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid transaminase ) or ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine degradation</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RR__45__BUTANEDIOL__45__DEHYDROGENASE__45__RXN" name="(R,R)-butanediol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BDH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-butanediol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of acetoin and butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: butanediol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTANEDIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCOSE_TO_UDP_COF_RXN" name="UDP-GLUCOSE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIAMIN__45__PYROPHOSPHOKINASE__45__RXN" name="Thiamine pyrophosphokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( THI80 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamin pyrophosphokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.2</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREDEHYD__45__RXN" name="Threonine dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ILV1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine deaminase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ECM38 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamyltransferase )</html:p>
<html:p>SUBSYSTEM: glutathione degradation</html:p>
<html:p>SUBSYSTEM: superpathway of glutathione metabolism (truncated &amp;gamma;-glutamyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>SIDE: _5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
      <speciesReference species="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHUROPORDEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.76</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4157" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase II )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.58</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTPDECARB__45__RXN" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( orotidine-5&apos;-phosphate decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.23</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATE__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Prephenate dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TYR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prephenate dehydrogenase (NADP+) )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.13</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__GLU__45__AMINOTRANSFORASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CAR2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine aminotransferase )</html:p>
<html:p>SUBSYSTEM: arginine degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: arginine degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2022" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC5 ) or ( PDC6 ) or ( PDC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of acetoin and butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROT__45__RXN" name="Dihydroorotase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URA4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrooratase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROG__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GUT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMPCYCLOHYDROLASE__45__RXN" name="IMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE17 ) or ( ADE16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOKIN__45__RXN" name="Galactokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GAL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactokinase )</html:p>
<html:p>SUBSYSTEM: galactose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__34__45__RXN" name="Hydroxymethylglutaryl-CoA reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HMG1 ) or ( HMG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) ) or ( 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4042" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCS7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( desaturase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOCERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__HYDROXYPHYTOCERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__15__45__RXN" name="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc-1-P-transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.15</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="CPD__45__190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNP__45__RXN" name="Purine-nucleoside phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PNP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PURINE" stoichiometry="1"/>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENMETSYN__45__RXN" name="Methionine adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SAM1 ) or ( SAM2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine synthetase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine salvage pathway</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine cycle</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__292" name="Ureidoglycolate hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DAL3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ureidoglycolate hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__31__45__RXN" name="Aminoadipate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha aminoadipate reductase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.31</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1079" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4108" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( THI3 ) or ( ARO10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( decarboxylase )</html:p>
<html:p>SUBSYSTEM: leucine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.1</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__4104" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4109" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH2 ) or ( ADH4 ) or ( ADH5 ) or ( ADH3 ) or ( ADH1 ) or ( SFA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: leucine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__4104" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOAMYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__DEHYDROPANTOATE__45__REDUCT__45__RXN" name="2-dehydropantoate 2-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAN5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gluconate 5-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.169</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__SYN__45__RXN" name="Glutathione synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione synthetase )</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of glutathione metabolism (truncated &amp;gamma;-glutamyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__II__45__RXN" name="GTP cyclohydrolase II" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RIB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP cyclohydrolase II )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.25</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="_25__45__DIAMINO__45__6__45__RIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEHYDROG__45__RXN" name="Homoserine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HOM6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__663" name="inositol phosphorylceramide mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CSG2 and SUR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA and NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
      <speciesReference species="IPC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MIPC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__132__45__RXN" name="Glycolipid 3-alpha-mannosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc2:Man2:Man transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.132</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__MANNOSYLCHITOBIOSYLDIPHOSPHODOLI" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__27" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7184" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG82 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSOPHOSPHOLIPASE__45__RXN" name="Lysophospholipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PLB1 ) or ( PLB2 ) or ( PLB3 ) or ( SPO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase B ) or ( phospholipase B ) or ( phospholipase B ) or ( phospholipase B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="_2__45__ACYLGLYCEROPHOSPHOCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__GLYCERO__45__PHOSPHORYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4038" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GDB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucanotranferase )</html:p>
<html:p>SUBSYSTEM: glycogen catabolism</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.33</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LANOSTEROL__45__SYNTHASE__45__RXN" name="Lanosterol synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-oxidosqualene-lanosterol cyclase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__229" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA__45__OXIDASE__45__RXN" name="Acyl-CoA oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( POX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty-acyl coenzyme A oxidase )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHACYL__45__COA__45__DEHYDROG__45__RXN" name="3-hydroxyacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FOX2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATESYN__45__RXN" name="Thymidylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CDC21 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate synthase subunit )</html:p>
<html:p>SUBSYSTEM: folate interconversions</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.45</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: DIHYDROFOLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLULOKIN__45__RXN" name="Xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( XKS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylulokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHS__45__PHOSPHATASE__45__RXN" name="dihydrosphingosine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LCB3 ) or ( YSR3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.91</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="EXOPOLYPHOSPHATASE__45__RXN" name="Exopolyphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PPX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOKINASE__45__RXN" name="Fructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HXK1 ) or ( HXK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase I ) or ( hexokinase II )</html:p>
<html:p>SUBSYSTEM: fructose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( YNK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGANINE__45__1__45__PHOSPHATE__45__ALDOLASE__45__RXN" name="Sphinganine-1-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DPL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrosphingosine phosphate lyase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.27</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMITALDEHYDE" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STR2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine gamma-synthase )</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: CPD__45__667</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DADP_TO_DATP_COF_RXN" name="DADP_TO_DATP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="DADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" name="L-ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__SYNTHASE__45__RXN" name="3-dehydroquinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRTRANS__45__RXN" name="Anthranilate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TRP4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anthranilate phosphoribosyl transferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINEKIN__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVIN__45__SYN__45__RXN" name="Riboflavin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RIB5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.9</html:p>
<html:p>SIDE: RIBITYLAMINO__45__AMINO__45__DIHYDROXY__45__PYR</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBITYLAMINO__45__AMINO__45__DIHYDROXY__45__PYR" stoichiometry="1"/>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROLDEHYDROG__45__RXN" name="Proline dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PUT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline oxidase )</html:p>
<html:p>SUBSYSTEM: proline utilization</html:p>
<html:p>SUBSYSTEM: arginine degradation (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHITIN__45__SYNTHASE__45__RXN" name="Chitin synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHS2 ) or ( CHS1 ) or ( CHS3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chitin synthase 2 ) or ( chitin synthase 1 ) or ( chitin synthase 3 )</html:p>
<html:p>SUBSYSTEM: chitin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.16</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHITIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHITIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOICASE__45__RXN" name="Allantoicase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DAL2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allantoicase )</html:p>
<html:p>SUBSYSTEM: allantoin degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDASE__45__YEAST__45__RXN" name="Ceramidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( YDC1 ) or ( YPC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceramidase ) or ( ceramidase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOCERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__2__45__RXN" name="Diacylglycerol cholinephosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sn-1,2-diacylglycerol cholinephosphotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis (Kennedy pathway)</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.2</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>SIDE: PHOSPHATIDYLCHOLINE</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYLCHOLINE__45__CMPD" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthetase )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOINDEHYDROG__45__RXN" name="acetoin dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BDH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-butanediol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of acetoin and butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.5</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IGPSYN__45__RXN" name="Indole-3-glycerol-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TRP3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.48</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Ubiquinones__124___TO___124__Ubiquinols__124___COF_RXN" name="|Ubiquinones|_TO_|Ubiquinols|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Ubiquinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ubiquinols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTSEMIALDEHYDROG__45__RXN" name="Glutamate-5-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PRO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamyl phosphate reductase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1461" name="Coproporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HEM13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aerobic coproporphyrinogen oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.3</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEME__45__OXYGENASE__45__DECYCLIZING__45__RXN" name="Heme oxygenase (decyclizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HMX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heme oxygenases )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIVERDINE" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSMANMUT__45__RXN" name="Phosphomannomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SEC53 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomannomutase )</html:p>
<html:p>SUBSYSTEM: dolichyl phosphate D-mannose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMIDASE__45__RXN" name="Amidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AMD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__32__MONOCARBOXYLIC__32__ACID__32__AMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__32__MONOCARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__LACTATE__45__DEHYDROGENASE__45__CYTOCHROME__45__RXN" name="L-lactate dehydrogenase (cytochrome)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYB2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-lactate cytochrome c oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.2.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__2361" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__2363" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__127__45__RXN" name="1D-myo-inositol-trisphosphate 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG82 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.127</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPRIBOSYLTRAN__45__RXN" name="Adenine phosphoribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( APT1 ) or ( APT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenine phosphoribosyltransferase ) or ( adenine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purines and their nucleosides</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.7</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_DIHYDROFOLATE_COF_RXN" name="METHYLENE-THF_TO_DIHYDROFOLATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPRIBOSYLTRAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine guanine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purines and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine and their nucleosides</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4114" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase II )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.58</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4116" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( THI3 ) or ( PDC5 ) or ( PDC6 ) or ( PDC1 ) or ( ARO10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.72</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLBUT__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4117" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH2 ) or ( ADH4 ) or ( ADH5 ) or ( ADH3 ) or ( ADH1 ) or ( SFA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLBUT__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__21__45__RXN" name="Farnesyl-diphosphate farnesyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene synthetase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTAMINOTRANS__45__RXN" name="Histidinol-phosphate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinol-phosphate aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.9</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACO1 ) or ( ACO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitase ) or ( aconitate hydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of TCA cycle and glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle, aerobic respiration</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ILV6 and ILV2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetolactate synthase, catalytic subunit and acetolactate synthase, regulatory subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDYLATE__45__SYNTHASE__45__RXN" name="Pseudouridylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PUS2 ) or ( CBF5 ) or ( PUS1 ) or ( PUS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pseudouridine synthase ) or ( pseudouridylate synthase ) or ( tRNA pseudouridine synthase ) or ( pseudouridine synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.70</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIACYLGLYCEROL__45__LIPASE__45__RXN" name="Triacylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TGL1 ) or ( TGL2 ) or ( ATG15 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TGL1 ) or ( triglyceride lipase ) or ( lipase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE_TO_L__45__ALPHA__45__ALANINE_COF_RXN" name="PYRUVATE_TO_L-ALPHA-ALANINE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__DELTA__45__ISOM__45__RXN" name="Dodecenoyl-CoA delta-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DCI1 ) or ( ECI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta(3,5)-delta(2,4)-dienoyl-CoA isomerase ) or ( d3,d2-Enoyl-CoA Isomerase )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__DELTA3__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4112" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase II )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.28</html:p>
<html:p>SIDE: PHE</html:p>
<html:p>SIDE: PHENYL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__3__46__37__45__RXN" name="D-arabinono-1,4-lactone oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-arabinono-1,4-lactone oxidase )</html:p>
<html:p>SUBSYSTEM: dehydro-D-arabinono-1,4-lactone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.37</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__356" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1789" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROSPHINGANINE__45__REDUCTASE__45__RXN" name="3-dehydrosphinganine reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TSC10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-ketosphinganine reductase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.102</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDROSPHINGANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Homoserine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoserine O-trans-acetylase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: homocysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.31</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGEN__45__STARCH__45__SYNTHASE__45__RXN" name="Glycogen (starch) synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GSY1 ) or ( GSY2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose-starch glucosyltransferase ) or ( UDP-glucose-starch glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.11</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBPSYN__45__RXN" name="Carbamoyl-phosphate synthase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GFA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucoseamine-6-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetylglucosamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.16</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__412" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc2:Man9:Glc transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: CPD__45__166</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__408" stoichiometry="1"/>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__409" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FARNESYLTRANSTRANSFERASE__45__RXN" name="Farnesyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BTS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.29</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__413" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DIE2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc2:Man9:Glc transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: CPD__45__166</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
      <speciesReference species="CPD3O__45__409" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD3O__45__410" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__HYDRAT__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FOX2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOHEMEFERROCHELAT__45__RXN" name="Ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HEM15 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoheme ferrolyase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARAGHYD__45__RXN" name="Asparaginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASP3-1 ) or ( ASP1 ) or ( ASP3-3 ) or ( ASP3-4 ) or ( ASP3-2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparaginase II ) or ( asparaginase I ) or ( asparaginase II ) or ( asparaginase II ) or ( asparaginase II )</html:p>
<html:p>SUBSYSTEM: asparagine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PALMITYL__45__COA_TO_CO__45__A_COF_RXN" name="PALMITYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PALMITYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__218" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-5 sterol desaturase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPISTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_572428__45__ERGOSTATRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOHMETRANS__45__RXN" name="Glycine hydroxymethyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SHM2 ) or ( SHM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase ) or ( Serine hydroxymethyltransferase, mitochondrial )</html:p>
<html:p>SUBSYSTEM: serine biosynthesis from glyoxylate</html:p>
<html:p>SUBSYSTEM: folate interconversions</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis from serine</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.1</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREONINE__45__ALDOLASE__45__RXN" name="Threonine aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLY1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine aldolase )</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis from threonine</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>SIDE: ACETALD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__411" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc2:Man9:Glc transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: CPD__45__166</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
      <speciesReference species="CPD3O__45__258" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__408" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__23__45__DIOXYGENASE__45__RXN" name="Tryptophan 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BNA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tryptophan 2,3-dioxygenase )</html:p>
<html:p>SUBSYSTEM: de novo NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan degradation via kynurenine</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.11</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__250" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLGLUTKIN__45__RXN" name="Acetylglutamate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG5,6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__214" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( URH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: nicotinate riboside salvage pathway II</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8259" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTURIDYLYLTRANS__45__RXN" name="UDP-glucose--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GAL7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GAL7 )</html:p>
<html:p>SUBSYSTEM: galactose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__217" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH2 ) or ( ADH4 ) or ( ADH5 ) or ( ADH3 ) or ( ADH1 ) or ( SFA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.190</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__341" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__FORMYLGLUTATHIONE__45__HYDROLASE__45__RXN" name="S-formylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__PEROXIDASE__45__RXN" name="Glutathione peroxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPX1 ) or ( GPX2 ) or ( HYR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutathione peroxidase ) or ( Glutathione peroxidase ) or ( glutathione-peroxidase )</html:p>
<html:p>SUBSYSTEM: glutathione-glutaredoxin redox reactions</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.9</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXI__45__RXN" name="Lactoylglutathione lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxalase I )</html:p>
<html:p>SUBSYSTEM: methylglyoxal catabolism</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.5</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITDEH__45__RXN" name="Isocitrate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IDP1 ) or ( IDP3 ) or ( IDP2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent isocitrate dehydrogenase ) or ( NADP-dependent isocitrate dehydrogenase ) or ( NADP-dependent isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of glutamate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THRESYN__45__RXN" name="Threonine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( THR4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.99.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENDECARBOX__45__RXN" name="Uroporphyrinogen decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HEM12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen decarboxylase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.37</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__227" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-22 sterol desaturase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_572428__45__ERGOSTATRIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_57222428__45__ERGOSTATETRAENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__71__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-24 sterol reductase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.71</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_57222428__45__ERGOSTATETRAENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERGOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__37" name="Carnitine O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CAT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mitochondrial and peroxisomal carnitine O-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: carnitine shuttle</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.7</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__ACETYLCARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPSYN__45__RXN" name="Tryptophan synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TRP5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthetase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GAP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__39" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CDC8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__56__45__RXN" name="Inositol-1,4,5-trisphosphate 5-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INP53 ) or ( INP52 ) or ( INP54 ) or ( INP51 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate 5-phosphatase ) or ( inositol polyphosphate 5-phosphatase ) or ( inositol polyphosphate 5-phosphatase ) or ( phosphatidylinositol 4,5-bisphosphate 5-phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__192" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__32" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NRK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: nicotinate riboside salvage pathway I</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8259" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BAT2 ) or ( BAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid transaminase ) or ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( YNK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP__45__MANNOSE_TO_GDP_COF_RXN" name="GDP-MANNOSE_TO_GDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDATE__45__PHOSPHATASE__45__RXN" name="Phosphatidate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: triglyceride biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTPRATPHYD__45__RXN" name="Phosphoribosyl-ATP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7162" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG82 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.151</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__318" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG26 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-3 sterol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4702" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4581" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__11__45__RXN" name="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PIS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylinositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.11</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__482" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__317" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 sterol methyl oxidase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4580" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4702" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__319" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG27 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-keto sterol reductase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4581" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__314" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG27 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-keto sterol reductase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4578" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__METHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__313" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG26 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-3 sterol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4577" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4578" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__10__46__2__46__2__45__RXN" name="Ubiquinol--cytochrome c reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( QCR10 ) or ( QCR6 ) or ( COB ) or ( RIP1 ) or ( QCR8 ) or ( QCR9 ) or ( COR1 ) or ( QCR7 ) or ( QCR2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ubiqunol-cytochrome c oxidoreductase ) or ( ubiquinol cytochrome C oxidoreductase ) or ( cytochrome b ) or ( ubiquinol-cytochrome c reductase ) or ( ubiquinol cytochrome C reductase ) or ( ubiquinol cytochrome c oxidoreductase ) or ( coenzyme QH2 cytochrome c reductase ) or ( ubiquinol cytochrome C oxidoreductase ) or ( ubiquinol cytochrome-c reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2361" stoichiometry="2"/>
      <speciesReference species="QH2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2363" stoichiometry="2"/>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__316" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 sterol methyl oxidase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4579" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4580" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Carnitine O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CAT2 ) or ( YAT1 ) or ( YAT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mitochondrial and peroxisomal carnitine O-acetyltransferase ) or ( carnitine acetyltransferase ) or ( carnitine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: carnitine shuttle</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.7</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__ACETYLCARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__315" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 sterol methyl oxidase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__METHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4579" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate kinase )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.158</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DETHIOBIOTIN__45__SYN__45__RXN" name="Dethiobiotin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BIO4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dethiobiotin synthetase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDPHOSDEHYD__45__RXN" name="Imidazoleglycerol-phosphate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( imidazole glycerol-phosphate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Aspartate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HOM2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartic beta semi-aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.11</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGINASE__45__RXN" name="Arginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase )</html:p>
<html:p>SUBSYSTEM: arginine degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: arginine degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLATECYC__45__RXN" name="Adenylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CYR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylate cyclase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__66" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: de novo NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan degradation via kynurenine</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTATE__45__DEHYDROGENASE__45__RXN" name="Dihydroorotate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.11</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__504" name="phytospingosine-1-P phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LCB3 ) or ( YSR3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.91</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHTYOSPHINGOSINE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__11__45__RXN" name="1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PLC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoinositide-specific phospholipase C )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__310" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 sterol methyl oxidase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4575" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITRATE__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Isocitrate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IDH1 and IDH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA and NAD-dependent isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of TCA cycle and glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle, aerobic respiration</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.41</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__D__45__RXN" name="Phospholipase D" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SPO14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase D )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__32__PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__32__PHOSPHATIDATE" stoichiometry="1"/>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__311" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 sterol methyl oxidase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4575" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4576" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__312" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 sterol methyl oxidase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4576" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4577" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAPASYN__45__RXN" name="Adenosylmethionine--8-amino-7-oxononanoate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BIO3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7,8-diamino-pelargonic acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.62</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_8__45__AMINO__45__7__45__OXONONANOATE" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACSERLY__45__RXN" name="Cysteine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.99.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCHOMOSERLYASE__45__RXN" name="O-succinylhomoserine (thiol)-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-succinylhomoserine (thiol)-lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.99.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANPRIBOSYLTRAN__45__RXN" name="Xanthine-guanine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( XPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine phosphoribosyl transferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purines and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine and their nucleosides</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.22</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIB5PISOM__45__RXN" name="Ribose 5-phosphate epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RKI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose-5-phosphate ketol-isomerase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: non-oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__1__46__6__45__RXN" name="Biotin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BIO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: CPD__45__249</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__249" stoichiometry="1"/>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
      <speciesReference species="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOPRIBOTRANS__45__RXN" name="Nicotinate-nucleotide pyrophosphorylase (carboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BNA6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Quinolinate phosphoribosyl transferase )</html:p>
<html:p>SUBSYSTEM: de novo NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan degradation via kynurenine</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.19</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IPPISOM__45__RXN" name="Isopentenyl-diphosphate delta-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IDI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopentenyl diphosphate:dimethylallyl diphosphate isomerase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__CH3__45__ALLYL__45__PPI" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINEPHOSPHOTRANSFERASE__45__RXN" name="Ethanolaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II (Kennedy pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.1</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__54" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-methyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: ubiquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HEXAPRENYL__45__6__45__METHOXY__45__14__45__BENZOQUINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HEXAPRENYL__45__3__45__METHYL__45__6__45__METHOXY__45__14__45__BENZ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__3__46__1__46__23__45__RXN" name="5-methylthioribose-1-phosphate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MRI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylthioribose-1 P isomerase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine salvage pathway</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.23</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1063" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__15__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MTD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: folate interconversions</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.15</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__P__45__OR__45__NOP_TO_NADH__45__P__45__OR__45__NOP_COF_RXN" name="NAD-P-OR-NOP_TO_NADH-P-OR-NOP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__ARABINOSE__45__1__45__DEHYDROGENASE__45__RXN" name="D-arabinose 1-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dehydro-D-arabinono-1,4-lactone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.116</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__356" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAM__45__RXN" name="Phosphoserine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SER1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine transaminase )</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis from 3-phosphoglycerate</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__205" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PNP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: nicotinate riboside salvage pathway II</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: RIBOSE__45__1P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8259" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__REDUCTASE__45__RXN" name="Aldehyde reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GRE3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylose reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.21</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALDITOL" stoichiometry="1"/>
      <speciesReference species="__124__Alditols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALDOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSGLYPHOS__45__RXN" name="Phosphoglycerate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PGK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-phosphoglycerate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__203" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-8 sterol isomerase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FECOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPISTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPOXANPRIBOSYLTRAN__45__RXN" name="Hypoxanthine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine guanine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purines and their nucleosides</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__39__45__RXN" name="4-hydroxybenzoate nonaprenyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( para-hydroxybenzoate polyprenyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: ubiquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: HEXAPRENYL__45__DIPHOSPHATE</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HEXAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONDEHYDROG__45__RXN" name="Phosphogluconate dehydrogenase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GND2 ) or ( GND1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase ) or ( 6-phosphogluconate dehydrogenase, decarboxylating )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: ubiquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HEXAPRENYL__45__3__45__METHYL__45__5__45__HYDROXY__45__6__45__METHOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__30" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTPSYN__45__RXN" name="CTP synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URA8 ) or ( URA7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CTP synthase ) or ( CTP synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROPORIIIMETHYLTRANSA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__GLN__45__RXN" name="NAD(+) synthase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( QNS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: de novo NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THF_TO_METHYLENE__45__THF_COF_RXN" name="THF_TO_METHYLENE-THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLTHFGLUSYNTH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthetase )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__458" name="PHS kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LCB4 ) or ( LCB5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.91</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHTYOSPHINGOSINE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANINE__45__DEAMINASE__45__RXN" name="Guanine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GUD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purines and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine and their nucleosides</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.3</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYL__45__KIN__45__RXN" name="Guanylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GUK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanylate kinase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__314" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( URH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.-</html:p>
<html:p>SIDE: _2__45__DEOXYRIBOSE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
      <speciesReference species="_2__45__DEOXYRIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__1__45__RXN" name="Nicotinamide-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NMA1 ) or ( NMA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nicotinamide/nicotinic acid mononucleotide adenylyltransferase ) or ( Nicotinamide/nicotinic acid mononucleotide adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: nicotinamide riboside salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Acceptor__124___TO___124__Donor__45__H2__124___COF_RXN" name="|Acceptor|_TO_|Donor-H2|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Aldehyde dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALD5 ) or ( ALD6 ) or ( ALD4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase (minor mitochondrial) ) or ( aldehyde dehydrogenase (major cytoplasmic) ) or ( aldehyde dehydrogenase (major  mitochondrial) )</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.4</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMP__45__DEHYDROG__45__RXN" name="IMP dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IMD2 ) or ( IMD4 ) or ( IMD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IMP dehydrogenase ) or ( IMP dehydrogenase ) or ( IMP dehydrogenase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.205</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIOHBUTANONEPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RIB3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__BUTANONE__45__P" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHITIN__45__DEACETYLASE__45__RXN" name="Chitin deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CDA2 ) or ( CDA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chitin deacetylase ) or ( chitin deacetylase )</html:p>
<html:p>SUBSYSTEM: chitosan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.41</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHITIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__Chitosan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__PHOSPHOFRUCTO__45__2__45__KINASE__45__RXN" name="6-phosphofructo-2-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PFK26 ) or ( PFK27 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructose-2-kinase ) or ( 6-phosphofructo-2-kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.105</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__535" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3PGAREARR__45__RXN" name="Phosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GPM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate mutase )</html:p>
<html:p>SUBSYSTEM: glycolysis</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( YNK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSEPHOSPHA__45__RXN" name="Trehalose-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate phosphatase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLGLUTPREDUCT__45__RXN" name="N-acetyl-gamma-glutamyl-phosphate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG5,6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYLGLUTAMATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URACIL__45__PRIBOSYLTRANS__45__RXN" name="Uracil phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FUR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UPRTase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__C__45__PALMITOYLTRANSFERASE__45__RXN" name="Serine C-palmitoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LCB2 ) or ( LCB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine palmitoyltransferase ) or ( serine palmitoyltransferase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.50</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PALMITYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PALMITYL__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROSPHINGANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOPHOSPHORYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: glycogen catabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: GLC__45__1__45__P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMINE__45__SYNTHASE__45__RXN" name="Spermine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SPE4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermine synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: spermine and methylthioadenosine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7711" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TSC13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEAMINASE__45__RXN" name="AMP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AMD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AMD1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purines and their nucleosides</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__5__45__DEHYDROGENASE__45__RXN" name="Shikimate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.25</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLTRANSFER__45__RXN" name="Amino-acid N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylglutamate synthase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__ISOPROPYLMALATESYN__45__RXN" name="2-isopropylmalate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LEU4 ) or ( LEU9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-isopropylmalate synthase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.13</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYRAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase I )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.5</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTOCHROME__45__C__45__OXIDASE__45__RXN" name="Cytochrome-c oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COX5B ) or ( COX2 ) or ( COX6 ) or ( COX5A ) or ( COX3 ) or ( COX7 ) or ( COX13 ) or ( COX4 ) or ( COX9 ) or ( COX8 ) or ( COX1 ) or ( MNE1 ) or ( COX12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome c oxidase chain Vb ) or ( cytochrome c oxidase subunit II ) or ( cytochrome c oxidase subunit ) or ( cytochrome c oxidase chain Va ) or ( cytochrome c oxidase subunit III ) or ( cytochrome c oxidase subunit VII ) or ( cytochrome c oxidase subunit VIa ) or ( cytochrome c oxidase subunit IV ) or ( cytochrome c oxidase subunit VIIa ) or ( cytochrome c oxidase chain VIII ) or ( cytochrome c oxidase subunit I ) or ( cytochrome oxidase ) or ( cytochrome c oxidase subunit VIb )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.9.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2363" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2361" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPISOM__45__RXN" name="Mannose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PMI40 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: dolichyl phosphate D-mannose biosynthesis</html:p>
<html:p>SUBSYSTEM: mannose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCMP__45__DEAMINASE__45__RXN" name="dCMP deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dCMP deaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__328" name="ceramide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LAG1 and LIP1 and LAC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceramide synthase subunit and ceramide synthase subunit and ceramide synthase subunit )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTOCERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__REDUCT__45__NADPH__45__RXN" name="Glutathione reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione oxidoreductase )</html:p>
<html:p>SUBSYSTEM: glutathione-glutaredoxin system</html:p>
<html:p>SUBSYSTEM: glutathione-glutaredoxin redox reactions</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPONTPRO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: arginine degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: arginine degradation (anaerobic)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYISOVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ILV3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxy-acid dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MEVALONATE__45__KINASE__45__RXN" name="Mevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mevalonate kinase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.36</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETHYLBILANESYN__45__RXN" name="Hydroxymethylbilane synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HEM3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( porphobilinogen deaminase )</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.61</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOSULFATE__45__SULFURTRANSFERASE__45__RXN" name="Thiosulfate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TUM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiosulfate sulfurtransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="1"/>
      <speciesReference species="CYANIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="HSCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PFRUCTPHOS__45__RXN" name="6-phosphofructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PFK2 and PFK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphofructokinase beta subunit and phosphofructokinase alpha subunit )</html:p>
<html:p>SUBSYSTEM: glycolysis</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMINE__45__OXIDASE__45__RXN" name="Amine oxidase (flavin-containing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FMS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amine oxidase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis</html:p>
<html:p>SUBSYSTEM: beta-alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__AMINOPROPANAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__142__45__RXN" name="Chitobiosyldiphosphodolichol alpha-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc2:Man transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.142</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLCNAC2PPDOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__MANNOSYLCHITOBIOSYLDIPHOSPHODOLI" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__SYNTHASE__45__RXN" name="Cystathionine beta-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-synthase )</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis/homocysteine degradation</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis from homocysteine</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.22</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__152__45__RXN" name="Inositol-hexakisphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( KCS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3842" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__151__45__RXN" name="Inositol-polyphosphate multikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG82 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.151</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSCHOL__45__RXN" name="Phospholipase D" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SPO14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase D )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE__45__CMPD" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__22" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MET7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthetase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation</html:p>
<html:p>SUBSYSTEM: superpathway of threonine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__METHYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__17__45__RXN" name="3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PDE2 ) or ( PDE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( high affinity cAMP phosphodiesterase ) or ( 3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase, low affinity )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NUCLEOSIDE__32__3__38__amp__59__apos__59____44__5__38__amp__59__apos__59____45__CYCLIC__32__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NUCLEOSIDE__32__5__38__amp__59__apos__59____45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISCBACSU__45__RXN" name="Histidinol-phosphate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinol-phosphate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.9</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__19__45__RXN" name="3-phosphoshikimate 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.19</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__PROPANAL__45__DEHYDROGENASE__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALD3 ) or ( ALD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase (stress inducible cytoplasmic) ) or ( aldehyde dehydrogenase (stress inducible cytoplasmic) )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis</html:p>
<html:p>SUBSYSTEM: beta-alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__AMINOPROPANAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLT_TO_GLN_COF_RXN" name="GLT_TO_GLN_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOTHENATE__45__KIN__45__RXN" name="Pantothenate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantothenate kinase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__349" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OPI3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( OPI3 )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.71</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__160" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYLCHOLINE__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGEN__45__BRANCH__45__RXN" name="1,4-alpha-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLC3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,4-glucan-6-(1,4-glucano)-transferase )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__348" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OPI3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( OPI3 )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.71</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__405" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__160" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARTRANSFORM__45__RXN" name="Phosphoribosylaminoimidazolecarboxamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE17 ) or ( ADE16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.3</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AICAR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENODEAMIN__45__RXN" name="Adenosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TAD1 ) or ( TAD3 ) or ( TAD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA-specific adenosine deaminase subunit ) or ( tRNA-specific adenosine deaminase subunit ) or ( tRNA-specific adenosine deaminase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__347" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( KCS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__250" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__144" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__1__46__109__45__RXN" name="Methylthioribulose 1-phosphate dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MDE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine salvage pathway</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.109</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1063" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8999" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2TRANSKETO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TKL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: non-oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LUMAZINESYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RIB4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lumazine synthase )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__BUTANONE__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BUD16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRROLINEDEH__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PUT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-1-pyrroline-5-carboxylate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__CH3__45__2__45__OXOBUTANOATE__45__OH__45__CH3__45__XFER__45__RXN" name="3-methyl-2-oxobutanoate hydroxymethyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ECM31 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methyl-2-oxobutanoate hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.11</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: METHYLENE__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__11" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc2:Man7:Man transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.130</html:p>
<html:p>SIDE: CPD__45__171</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__2" stoichiometry="1"/>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD3O__45__10" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__10" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GLK1 ) or ( HXK1 ) or ( HXK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucokinase ) or ( hexokinase I ) or ( hexokinase II )</html:p>
<html:p>SUBSYSTEM: mannose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__12" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monooxygenase )</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: ubiquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HEXAPRENYL__45__6__45__METHOXYPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HEXAPRENYL__45__6__45__METHOXY__45__14__45__BENZOQUINOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTCYCLOHYD__45__RXN" name="Phosphoribosyl-AMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE__45__CARBOXYLASE__45__RXN" name="Pyruvate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PYC1 ) or ( PYC2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate carboxylase ) or ( pyruvate carboxylase )</html:p>
<html:p>SUBSYSTEM: aspartate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of TCA cycle and glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: TCA cycle, aerobic respiration</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GAL10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: galactose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLT_TO_2__45__KETOGLUTARATE_COF_RXN" name="GLT_TO_2-KETOGLUTARATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONOLACT__45__RXN" name="6-phosphogluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SOL4 ) or ( SOL3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase ) or ( 6-phosphogluconolactonase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R81__45__RXN" name="Hexokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HXK1 ) or ( HXK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase I ) or ( hexokinase II )</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UREIDOGLYCOLATE__45__LYASE__45__RXN" name="Ureidoglycolate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DAL3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ureidoglycolate hydrolase )</html:p>
<html:p>SUBSYSTEM: allantoin degradation</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.3</html:p>
<html:p>SIDE: GLYOX</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYCEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Diacylglycerol O-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DGA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DiacylGlycerol Acyltransferase )</html:p>
<html:p>SUBSYSTEM: triglyceride biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.20</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_ADP_COF_RXN" name="ATP_TO_ADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEPHOSPHOCOAKIN__45__RXN" name="Dephospho-CoA kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAB5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dephospho-CoA kinase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCISOM__45__RXN" name="Glucose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PGI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: glycolysis</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMET__45__RXN" name="5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine cycle</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.14</html:p>
<html:p>SIDE: CPD__45__1301</html:p>
<html:p>SIDE: CPD__45__1302</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1302" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1301" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THI__45__P__45__SYN__45__RXN" name="Thiamine-phosphate pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( THI6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( THI6 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THZ__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__248" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INP53 ) or ( SAC1 ) or ( INP52 ) or ( FIG4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phosphatidylinositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__1D__45__MYO__45__INOSITOL__45__35__45__BISPH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTKIN__45__RXN" name="Glutamate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PRO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamyl kinase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITSYN__45__RXN" name="Citrate (si)-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CIT1 ) or ( CIT2 ) or ( CIT3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( citrate synthase ) or ( citrate synthase ) or ( citrate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of TCA cycle and glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle, aerobic respiration</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMARATE__45__REDUCTASE__45__NADH__45__RXN" name="Fumarate reductase (NADH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OSM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarate reductase (NADH) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.6</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULP3EPIM__45__RXN" name="ribulose phosphate 3-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RPE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-ribulose-5-Phosphate 3-epimerase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: non-oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__5__46__1__45__RXN" name="Nitrilase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NIT2 ) or ( NIT1 ) or ( NIT3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrilase ) or ( nitrilase ) or ( nitrilase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nitriles__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__1__45__PHOSPHATASE__45__RXN" name="Glycerol-1-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HOR2 ) or ( RHR2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DL-glycerol-3-phosphatase ) or ( DL-glycerol-3-phosphatase )</html:p>
<html:p>SUBSYSTEM: glycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.21</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__178" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SAM:C-24 sterol methyltransferase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.41</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FECOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINKIN__45__RXN" name="Riboflavin kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FMN1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( riboflavin kinase )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Fatty__45__Acyl__45__CoA__124___TO_CO__45__A_COF_RXN" name="|Fatty-Acyl-CoA|_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16BDEPHOS__45__RXN" name="Fructose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FBP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-1,6-bisphosphatase )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__141__45__RXN" name="N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG13 and ALG14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine transferase Alg14p subunit and UDP-N-acetylglucosamine transferase Alg13p subunit )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.141</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__190" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLCNAC2PPDOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__171" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexaprenyl diphosphate synthetase )</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLFARNESYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__20__45__RXN" name="Methylenetetrahydrofolate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET13 ) or ( MET12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MTHFR ) or ( MTHFR )</html:p>
<html:p>SUBSYSTEM: folate interconversions</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.20</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SIROHEME__45__FERROCHELAT__45__RXN" name="Sirohydrochlorin ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCC__45__FUM__45__OXRED__45__UBI__45__RXN" name="Succinate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SDH3 and SDH4 and SDH1 and SDH2 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate dehydrogenase iron-sulfur protein subunit and succinate dehydrogenase flavoprotein and succinate dehydrogenase cytochrome b and succinate dehydrogenase membrane anchor subunit ) or ( succinate dehydrogenase (ubiquinone) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__6" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="UBIQUINOL__45__30" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEHYDR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitase )</html:p>
<html:p>SUBSYSTEM: superpathway of TCA cycle and glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle, aerobic respiration</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-D-GLUCOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGENIN__45__GLUCOSYLTRANSFERASE__45__RXN" name="Glycogenin glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLG2 ) or ( GLG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogenin glucosyltransferase ) or ( glycogenin glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.186</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: GLYCOGENIN</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOGENIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTEPADENYLYLTRAN__45__RXN" name="Pantetheine-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAB4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantetheine-phosphate adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.3</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__378" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc2:Man2:Man transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__27" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__28" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__376" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( URK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R223__45__RXN" name="Long-chain-fatty-acid--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAA4 ) or ( FAA1 ) or ( FAT1 ) or ( FAA2 ) or ( FAA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( long chain fatty acyl:CoA synthetase ) or ( long chain fatty acyl:CoA synthetase ) or ( fatty acid transporter ) or ( acyl-CoA synthetase ) or ( acyl-CoA synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__196" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXKIN__45__RXN" name="Pyridoxal kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BUD16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPPSYN__45__RXN" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG20 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl diphosphate synthetase )</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__CH3__45__ALLYL__45__PPI" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__379" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG11 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__28" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__29" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNCARBAMTRANSFER__45__RXN" name="Ornithine carbamoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine carbamoyltransferase )</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__FORMYL__45__THF__45__CYCLO__45__LIGASE__45__RXN" name="5-formyltetrahydrofolate cyclo-ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FAU1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5,10-methenyltetrahydrofolate synthetase )</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDRAT__45__RXN" name="Prephenate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PHA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prephenate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.51</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINSYN__45__RXN" name="Argininosuccinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginosuccinate synthetase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6081" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of acetoin and butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIPHOSPHOMEVALONTE__45__DECARBOXYLASE__45__RXN" name="Diphosphomevalonate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MVD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mevalonate pyrophosphate decarboxylase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__163" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH2 ) or ( ADH4 ) or ( ADH5 ) or ( ADH3 ) or ( ADH1 ) or ( SFA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLETHANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__KINASE__45__RXN" name="Choline kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CKI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis (Kennedy pathway)</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.32</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PNP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purines and their nucleosides</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: RIBOSE__45__1P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOSYLNICOTINAMIDE__45__KINASE__45__RXN" name="Ribosylnicotinamide kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NRK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: nicotinamide riboside salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.22</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__164" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RIB2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DRAP deaminase )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_25__45__DIAMINO__45__6__45__RIBITYLAMINO__45__43H__45__PYRIMID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINAMID__45__RXN" name="Nicotinamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PNC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinamidase )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__45__PHOSPHATIDYLINOSITOL__45__3__45__KINASE__45__RXN" name="1-phosphatidylinositol 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( VPS34 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 3-kinase )</html:p>
<html:p>SUBSYSTEM: phosphatidylinositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.137</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__482" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__68__45__RXN" name="2-deoxyglucose-6-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DOG1 ) or ( DOG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-deoxyglucose-6-phosphate phosphatase ) or ( 2-deoxyglucose-6-phosphate phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.68</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__deoxy__45__D__45__glucose__32__6__45__phosphate" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEOXY__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIOSEPISOMERIZATION__45__RXN" name="Triosephosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triosephosphate isomerase )</html:p>
<html:p>SUBSYSTEM: glycolysis</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCITRATE__45__SYNTHASE__45__RXN" name="Homocitrate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS21 ) or ( LYS20 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homocitrate synthase ) or ( homocitrate synthase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.21</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__AMINOLEVULINIC__45__ACID__45__SYNTHASE__45__RXN" name="5-aminolevulinic acid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HEM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-aminolevulinate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.37</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KYNURENINE__45__3__45__MONOOXYGENASE__45__RXN" name="Kynurenine 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BNA4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Kynurenine 3-mono oxygenase )</html:p>
<html:p>SUBSYSTEM: de novo NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan degradation via kynurenine</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.9</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDINEKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__364" name="Phosphatidylinositol-3-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INP53 ) or ( SAC1 ) or ( INP52 ) or ( YMR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phosphatidylinositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.64</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__482" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FADSYN__45__RXN" name="FMN adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FAD synthetase )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.2</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROKAEMPFEROL__45__4__45__REDUCTASE__45__RXN" name="Dihydrokaempferol 4-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GRE2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroflavonol 4-reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.219</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEUCOPELARGONIDIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROKAEMPFEROL__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2NEOPTERINALDOL__45__RXN" name="Dihydroneopterin aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FOL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: folate biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.25</html:p>
<html:p>SIDE: GLYCOLALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__NEO__45__PTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
      <speciesReference species="GLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__156" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC5 ) or ( PDC6 ) or ( PDC1 ) or ( ARO10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPAMIDOTRANS__45__RXN" name="Amidophosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylpyrophosphate amidotransferase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.14</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMATE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Glutamate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylornithine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.35</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__257" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INP53 ) or ( SAC1 ) or ( INP52 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phosphatidylinositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__482" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__131__45__RXN" name="Glycolipid 2-alpha-mannosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG11 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__29" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__292" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPDEPHOS__45__RXN" name="Pyruvate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CDC19 ) or ( PYK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate kinase ) or ( pyruvate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.40</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__258" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( VIP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__250" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__C__45__RXN" name="Phospholipase C" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ISC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol phosphosphingolipid phospholipase C )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE__45__CMPD" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__259" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc2:Man6:Man transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.130</html:p>
<html:p>SIDE: CPD__45__171</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
      <speciesReference species="CPD3O__45__10" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__258" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBDEHYDROG__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PUT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-1-pyrroline-5-carboxylate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: proline utilization</html:p>
<html:p>SUBSYSTEM: arginine degradation (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOISOCITRATE__45__DEHYDROGENASE__45__RXN" name="Homoisocitrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homo-isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.155</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__I__45__CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__117__45__RXN" name="D-arabinose 1-dehydrogenase (NAD(P)+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-arabinose dehydrogenase )</html:p>
<html:p>SUBSYSTEM: dehydro-D-arabinono-1,4-lactone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.117</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__356" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QOR__45__RXN" name="NADPH:quinone reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ZTA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinone oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Semiquinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOPORGENOXI__45__RXN" name="Protoporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HEM14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoporphyrinogen oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLU6PDEHYDROG__45__RXN" name="Glucose-6-phosphate 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ZWF1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.49</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__75" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAT5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monooxygenase )</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: ubiquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.13.-.-</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HEXAPRENYL__45__3__45__METHYL__45__6__45__METHOXY__45__14__45__BENZ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HEXAPRENYL__45__3__45__METHYL__45__5__45__HYDROXY__45__6__45__METHOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__143" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( VIP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3842" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__144" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PABASYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ABZ1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: folate biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.8</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__145" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG24 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-14 sterol reductase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSDECARB__45__RXN" name="Phosphopantothenoylcysteine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VHS3 ) or ( CAB3 ) or ( SIS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphopantothenoylcysteine decarboxylase ) or ( phosphopantothenoylcysteine decarboxylase ) or ( phosphopantothenoylcysteine decarboxylase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.36</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__PHOSPHOPANTOTHENOYLCYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UMPKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URA6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridylate kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATEKIN__45__RXN" name="Aspartate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HOM3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-aspartate 4-P-transferase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTERIDINEPYROPHOSPHOKIN__45__RXN" name="2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FOL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: folate biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTALDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__89__45__RXN" name="N-acetylglucosaminylphosphatidylinositol deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GPI12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosaminylphosphatidylinositol de-N-acetylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.89</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__452" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__1113" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FGAMSYN__45__RXN" name="Phosphoribosylformylglycinamidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-phosphoribosylformyl glycinamidine synthetase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOACONITATE__45__HYDRATASE__45__RXN" name="Homoaconitate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoaconitase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.36</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBOXYHEXENEDIOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__I__45__CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTPPYPHOSKIN__45__RXN" name="GTP pyrophosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTC2 ) or ( VTC4 ) or ( VTC3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyphosphate synthetase ) or ( polyphosphate synthetase ) or ( polyphosphate synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__TP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROL__45__GLUCOSYLTRANSFERASE__45__RXN" name="Sterol glucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ATG26 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Udp-glycosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.173</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sterols__124__" stoichiometry="1"/>
      <speciesReference species="A__32__STEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AN__32__O__45__GLUCOSYLSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLYLSULFKIN__45__RXN" name="Adenylylsulfate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylylsulfate kinase )</html:p>
<html:p>SUBSYSTEM: sulfate assimilation pathway</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.25</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_PROPIONYL__45__COA_COF_RXN" name="CO-A_TO_PROPIONYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCC__45__FUM__45__OXRED__45__RXN" name="Succinate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SDH3 and SDH4 and SDH1 and SDH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate dehydrogenase iron-sulfur protein subunit and succinate dehydrogenase flavoprotein and succinate dehydrogenase cytochrome b and succinate dehydrogenase membrane anchor subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.1</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__281" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene synthetase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADH__45__DEHYDROG__45__A__45__RXN" name="NADH dehydrogenase (ubiquinone)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NDI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH dehydrogenase (ubiquinone) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINONE__45__6" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__30" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__131" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PNP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: nicotinamide riboside salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: RIBOSE__45__1P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTP_TO_CDP_COF_RXN" name="CTP_TO_CDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GABATRANSAM__45__RXN" name="4-aminobutyrate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-aminobutyrate (GABA) transaminase )</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: glutamate degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_325__45__BISPHOSPHATE__45__NUCLEOTIDASE__45__RXN" name="3&apos;(2&apos;),5&apos;-bisphosphate nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MET22 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&apos;(2&apos;)5&apos;-bisphosphate nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__130" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG11 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 lanosterol 14a-demethylase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSD1 ) or ( PSD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine decarboxylase, mitochondria ) or ( phosphatidylserine decarboxylase, golgi/vacuole )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.65</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__274" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALD5 ) or ( ALD4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase (minor mitochondrial) ) or ( aldehyde dehydrogenase (major  mitochondrial) )</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCGLU__45__SEMIALDEHYDE__45__SUCCGLU__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PUT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-1-pyrroline-5-carboxylate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__SUCCINYLGLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHEAMINOTRANS__45__DEG__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase I )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__26__45__RXN" name="Beta-fructofuranosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SUC2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( invertase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.26</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARDIOLIPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CRD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cardiolipin synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARDIOLIPIN" stoichiometry="1"/>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSHTRAN__45__RXN" name="Glutathione transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GTT1 ) or ( GTT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione transferase ) or ( glutathione transferase )</html:p>
<html:p>SUBSYSTEM: glutathione-glutaredoxin redox reactions</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>SIDE: CPD1G__45__160</html:p>
<html:p>SIDE: CPD1G__45__159</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__159" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__R__45__S__45__glutathione__124__" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__160" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYMETHYLENEBUTENOLIDASE__45__RXN" name="Carboxymethylenebutenolidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dienelactone hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.45</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CARBOXYMETHYLENEBUT__45__2__45__EN__45__4__45__OLIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXOHEX__45__2__45__ENEDIOATE" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMIDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( imidazoleglycerol phosphate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATEPRIBOSYLTRANS__45__RXN" name="Nicotinate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate phosphoribosyl transferase )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__127" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( saccharopine dehydrogenase (NADP+, L-glutamate-forming) )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.10</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="CPD__45__1079" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( YNK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG1P__45__URIDYLTRANS__45__RXN" name="UDP-N-acetylglucosamine pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( QRI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine pyrophosphorylase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetylglucosamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.23</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R147__45__RXN" name="Acireductone dioxygenase (Fe(2+)-requiring)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of methionine salvage pathway</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.54</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTDEAM__45__RXN" name="Cytosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FCY1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__METHYLTHIOADENOSINE__45__PHOSPHORYLASE__45__RXN" name="5&apos;-methylthioadenosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MEU1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine salvage pathway</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.28</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ADENINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALSYN__45__RXN" name="Malate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MLS1 ) or ( DAL7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate synthase ) or ( malate synthase 2 )</html:p>
<html:p>SUBSYSTEM: superpathway of TCA cycle and glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.9</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="Myo-inositol-1(or 4)-monophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( INM1 ) or ( INM2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol monophosphatase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALANINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Alanine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AGX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis from glyoxylate</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.44</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINE__45__KINASE__45__RXN" name="Ethanolamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EKI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ethanolamine kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II (Kennedy pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.82</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYL__45__ALCOHOL__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AAD4 ) or ( AAD3 ) or ( AAD14 ) or ( AAD6 ) or ( AAD10 ) or ( AAD15 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__Aldehyde__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALA__45__RXN" name="Alpha,alpha-trehalase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NTH1 ) or ( ATH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( neutral trehalase ) or ( acid trehalase )</html:p>
<html:p>SUBSYSTEM: trehalose degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.28</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="PORPHOBILSYNTH__45__RXN" name="Porphobilinogen synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HEM2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-aminolevulinate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.24</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTMPKI__45__RXN" name="Thymidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CDC8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__110" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RIB7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_25__45__DIAMINO__45__6__45__RIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_25__45__DIAMINO__45__6__45__RIBITYLAMINO__45__43H__45__PYRIMID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__46__45__RXN" name="Fructose-2,6-bisphosphate 2-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FBP26 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-2,6-bisphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__535" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTAGLY__45__RXN" name="Cystathionine gamma-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYS3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine gamma-lyase )</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>SUBSYSTEM: threonine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis/homocysteine degradation</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis from homocysteine</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R311__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AMD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__117" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: ubiquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINOL__45__30" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBREDUCT__45__RXN" name="Pyrroline-5-carboxylate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PRO3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta 1-pyrroline-5-carboxylate reductase )</html:p>
<html:p>SUBSYSTEM: arginine degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: arginine degradation (anaerobic)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__114__45__RXN" name="Hexaprenyldihydroxybenzoate methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: ubiquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.114</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HEXAPRENYL__45__45__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHOXY__45__4__45__HYDROXY__45__5__45__HEXAPRENYLBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPCARBTRANS__45__RXN" name="Aspartate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.2</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__112" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ECM38 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__291" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dol-PP-GlcNAc2:Man5:Man transferase )</html:p>
<html:p>SUBSYSTEM: lipid-linked oligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.130</html:p>
<html:p>SIDE: CPD__45__171</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3O__45__292" stoichiometry="1"/>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD3O__45__340" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYMETVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ILV3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxy-acid dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__249__45__RXN" name="[eIF-5A]-deoxyhypusine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DYS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyhypusine synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.249</html:p>
<html:p>GENERIC: true</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__eIF__45__5A__93____45__lysine" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__eIF__45__5A__93____45__deoxyhypusine" stoichiometry="1"/>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8441" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: nicotinamide riboside salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINLYA__45__RXN" name="Argininosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRCARBOXY__45__RXN" name="Phosphoribosylaminoimidazole carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole-carboxylase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIENOYLCOAREDUCT__45__RXN" name="2,4-dienoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SPS19 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dienoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="T2__45__DECENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="T2__45__C4__45__DECADIENYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__74__45__RXN" name="Indolepyruvate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC5 ) or ( PDC6 ) or ( PDC1 ) or ( ARO10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.74</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="Myo-inositol-1-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( INO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-myo-inositol-1-phosphate synthase subunit )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXII__45__RXN" name="Hydroxyacylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLO4 ) or ( GLO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxylase-II ) or ( glyoxylase-II )</html:p>
<html:p>SUBSYSTEM: methylglyoxal catabolism</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NAD__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MAE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malic enzyme )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.38</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC5 ) or ( PDC6 ) or ( PDC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of acetoin and butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.1</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__801" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PAD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phenylacrylic acid decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1072" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALDEHYDROG__45__RXN" name="3-isopropylmalate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LEU2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-IPM dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.85</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDYLINOSITOL__45__BISPHOSPHATASE__45__RXN" name="Phosphatidylinositol-bisphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INP51 ) or ( INP53 ) or ( INP52 ) or ( INP54 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phosphatidylinositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.36</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PHS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCDEHYDROG__45__RXN" name="Phosphoglycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SER33 ) or ( SER3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-phosphoglycerate dehydrogenase ) or ( 3-phosphoglycerate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis from 3-phosphoglycerate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.95</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTCYSLIG__45__RXN" name="Glutamate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamylcysteine synthetase )</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of glutathione metabolism (truncated &amp;gamma;-glutamyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7698" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IFA38 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__LACTATE__45__DEHYDROGENASE__45__CYTOCHROME__45__RXN" name="D-lactate dehydrogenase (cytochrome)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DLD2 ) or ( DLD1 ) or ( DLD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DLD2 ) or ( D-lactate ferricytochrome c oxidoreductase ) or ( DLD3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2361" stoichiometry="2"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__2363" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNTRANSAM__45__RXN" name="Acetylornithine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylornithine aminotransferase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.11</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYLGLUTAMATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__7__45__RXN" name="Saccharopine dehydrogenase (NAD+, L-lysine forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.7</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREOSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: threonine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMPSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENIIISYN__45__RXN" name="Uroporphyrinogen-III synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HEM4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen III synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of heme and siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.75</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_10__45__FORMYL__45__THF_TO_THF_COF_RXN" name="10-FORMYL-THF_TO_THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADCLY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ABZ2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminodeoxychorismate lyase )</html:p>
<html:p>SUBSYSTEM: folate biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.38</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSACETYLGLUCOSAMINEMUT__45__RXN" name="Phosphoacetylglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PCM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoacetylglucosamine mutase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetylglucosamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP cyclohydrolase I" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FOL2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP-cyclohydrolase I )</html:p>
<html:p>SUBSYSTEM: folate biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.16</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREDEHYD2__45__RXN" name="Threonine dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine/threonine dehydratase )</html:p>
<html:p>SUBSYSTEM: threonine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATEREDUCT__45__RXN" name="Dihydrofolate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DFR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: folate interconversions</html:p>
<html:p>SUBSYSTEM: folate biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__SYNTHASE__45__RXN" name="Hydroxymethylglutaryl-CoA synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl coenzyme A synthase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.5</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE__45__DECARBOXYLASE__45__RXN" name="Pyruvate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC5 ) or ( PDC6 ) or ( PDC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPCARBOXYKIN__45__RXN" name="Phosphoenolpyruvate carboxykinase (ATP)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PCK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoenolpyruvate carboxylkinase )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.49</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM__45__RXN" name="Cytidine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CDD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINEPNACETYLTRANS__45__RXN" name="Glucosamine-phosphate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GNA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine-phosphate N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetylglucosamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.4</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOASYN__45__RXN" name="Long-chain-fatty-acid--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAA4 ) or ( FAA1 ) or ( FAT1 ) or ( FAA2 ) or ( FAA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( long chain fatty acyl:CoA synthetase ) or ( long chain fatty acyl:CoA synthetase ) or ( fatty acid transporter ) or ( acyl-CoA synthetase ) or ( acyl-CoA synthase )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Saturated__45__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUTP__45__PYROP__45__RXN" name="dUTP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DUT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dUTP pyrophosphatase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__143__45__RXN" name="Diphosphate-purine nucleoside kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FAB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-phosphatidylinositol-3-phosphate 5-kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.143</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__32__PURINE__32__MONONUCLEOSIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINASE__45__RXN" name="Adenosylhomocysteinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SAH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosyl-L-homocysteine hydrolase )</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine cycle</html:p>
<html:p>PROTEIN_CLASS: 3.3.1.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAHPSYN__45__RXN" name="2-dehydro-3-deoxyphosphoheptonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO3 ) or ( ARO4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-D-arabine-heptulosonate-7-phosphate synthase ) or ( 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.54</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__8__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPD2 ) or ( GPD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase (NAD+) ) or ( glycerol 3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNB__45__RXN" name="Asparagine synthase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASN2 ) or ( ASN1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ASN2 ) or ( ASN1 )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.4</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="Adenylosuccinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate synthetase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.4</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOGLUCMUT__45__RXN" name="Phosphoglucomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PGM1 ) or ( PGM2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglucomutase ) or ( phosphoglucomutase )</html:p>
<html:p>SUBSYSTEM: galactose degradation</html:p>
<html:p>SUBSYSTEM: dolichyl glucosyl phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEH__45__RXN" name="Malate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MDH2 ) or ( MDH3 ) or ( MDH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosolic malate dehydrogenase subunit ) or ( peroxisome malate dehydrogenase subunit ) or ( mitochondrial malate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of TCA cycle and glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: TCA cycle, aerobic respiration</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.37</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__37__45__RXN" name="2&apos;,3&apos;-cyclic nucleotide 3&apos;-phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CPD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2&apos;,3&apos;-cyclic nucleotide 3&apos;-phosphodiesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.37</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NUCLEOSIDE__32__2__38__amp__59__apos__59____45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEXOKINASE__45__RXN" name="Hexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HXK1 ) or ( HXK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase I ) or ( hexokinase II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Hexoses__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__HEXOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNPOXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDX3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine phosphate oxidase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA_TO_CO__45__A_COF_RXN" name="ACETYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOMEVALONATE__45__KINASE__45__RXN" name="Phosphomevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomevalonate kinase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTDECARBOX__45__RXN" name="Glutamate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GAD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate decarboxylase )</html:p>
<html:p>SUBSYSTEM: glutamate degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.15</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOKIN__45__RXN" name="Glucokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucokinase )</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="Ribose-phosphate pyrophosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PRS2 ) or ( PRS3 ) or ( PRS5 ) or ( PRS1 ) or ( PRS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose-phosphate pyrophosphokinase ) or ( ribose-phosphate pyrophosphokinase ) or ( phosphoribosylpyrophosphate synthetase ) or ( ribose-phosphate pyrophosphokinase ) or ( ribose-phosphate pyrophosphokinase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP__45__ADENYLYLTRANSFERASE__45__RXN" name="ATP adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( APA2 ) or ( APA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;,5&apos;&apos;&apos;-P-1,P-4-tetraphosphate phosphorylase II ) or ( diadenosine 5&apos;,5&apos;&apos;&apos;-P1,P4-tetraphosphate phosphorylase I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.53</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__P4" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENINE__45__DEAMINASE__45__RXN" name="Adenine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AAH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenine aminohydrolase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purines and their nucleosides</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.2</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__1380" name="dihydrospingosine C-4 hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SUR2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrosphingosine C-4 hydroxylase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTP_TO_CMP_COF_RXN" name="CTP_TO_CMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GUA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GMP synthase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.2</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOATE__45__BETA__45__ALANINE__45__LIG__45__RXN" name="Pantoate--beta-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAN6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantoate-beta-alanine ligase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FPPSYN__45__RXN" name="Geranyltranstransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG20 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl diphosphate synthetase )</html:p>
<html:p>SUBSYSTEM: superpathway of ubiquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAMKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BUD16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCIT__45__CLEAV__45__RXN" name="Isocitrate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ICL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate lyase )</html:p>
<html:p>SUBSYSTEM: superpathway of TCA cycle and glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LEUKOTRIENE__45__A4__45__HYDROLASE__45__RXN" name="Leukotriene-A4 hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LAP2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( leukotriene A4 hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_7E9E11Z14Z__45__5S6S__45__56__45__EPOXYICOSA__45__7" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6Z8E10E14Z__45__5S12R__45__512__45__DIHYDROXYI" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTOLDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__1983" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoaconitase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.36</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYHEXENEDIOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD_TO_NADH_COF_RXN" name="NAD_TO_NADH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__KINASE__45__RXN" name="shikimate-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.71</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__1298" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH2 ) or ( ADH4 ) or ( ADH5 ) or ( ADH3 ) or ( ADH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__1070" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AYR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-acyl dihydroxyacetone phosphate reductase )</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.101</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__ACYL__45__DIHYDROXYACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOKIN__45__RXN" name="Ribokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RBK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.15</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHENYLTHFCYCLOHYDRO__45__RXN" name="Methenyltetrahydrofolate cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MIS1 ) or ( ADE3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mitochondrial C1-tetrahydrofolate synthase ) or ( C1-tetrahydrofolate synthase )</html:p>
<html:p>SUBSYSTEM: folate interconversions</html:p>
<html:p>SUBSYSTEM: folate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__68__45__RXN" name="1-phosphatidylinositol-4-phosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MSS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 4-phosphate kinase )</html:p>
<html:p>SUBSYSTEM: phosphatidylinositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.68</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2PGADEHYDRAT__45__RXN" name="Phosphopyruvate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ENO2 ) or ( ENO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enolase ) or ( enolase I )</html:p>
<html:p>SUBSYSTEM: glycolysis</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TKL2 ) or ( TKL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase ) or ( transketolase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: non-oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZYL__45__ALCOHOL__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AAD4 ) or ( AAD3 ) or ( AAD14 ) or ( AAD6 ) or ( AAD10 ) or ( AAD15 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase ) or ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OH__45__BENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OH__45__BENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDPHOS__45__RXN" name="Histidinol-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinolphosphatase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.15</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__IDITOL__45__2__45__DEHYDROGENASE__45__RXN" name="L-iditol 2-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SOR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__369" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERSYN__45__RXN" name="CDP-diacylglycerol--serine O-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CHO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.8</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__470" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC5 ) or ( PDC6 ) or ( PDC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decarboxylase ) or ( decarboxylase ) or ( decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of acetoin and butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA_TO_CO__45__A_COF_RXN" name="MALONYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__3__45__RXN" name="Glucan 1,4-alpha-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SGA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycogen catabolism</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GLYCOGENN__45__1" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINESYN__45__RXN" name="Spermidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SPE3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putrescine aminopropyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine salvage pathway</html:p>
<html:p>SUBSYSTEM: spermidine and methylthioadenosine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__361" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( URH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNDECARBOX__45__RXN" name="Ornithine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SPE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.17</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__KIN__45__RXN" name="Glycerol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GUT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol kinase )</html:p>
<html:p>SUBSYSTEM: glycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.30</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URKI__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__77__45__RXN" name="Acireductone synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UTR4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine salvage pathway</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.77</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8999" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ILV6 and ILV2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetolactate synthase, catalytic subunit and acetolactate synthase, regulatory subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of acetoin and butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__150__45__RXN" name="1-phosphatidylinositol-3-phosphate 5-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FAB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-phosphatidylinositol-3-phosphate 5-kinase )</html:p>
<html:p>SUBSYSTEM: phosphatidylinositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.150</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__1D__45__MYO__45__INOSITOL__45__35__45__BISPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERKIN__45__RXN" name="Homoserine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( THR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoserine kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.39</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ILV5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetohydroxyacid reductoisomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__83__45__RXN" name="Dolichyl-phosphate beta-D-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DPM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dolichol phosphate mannose synthase )</html:p>
<html:p>SUBSYSTEM: dolichyl phosphate D-mannose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.83</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: DOLICHOLP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLULOSE__45__REDUCTASE__45__RXN" name="D-xylulose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( XYL2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Xylitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PMPOXI__45__RXN" name="Pyridoxamine-phosphate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDX3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine phosphate oxidase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__43__45__RXN" name="Phosphatidylcholine--sterol O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LRO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Lecithin cholesterol acyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.43</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sterols__124__" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="STEROL" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="STEROL__32__ESTER" stoichiometry="1"/>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="L__45__1__45__LYSOLECITHIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPRODEHYDROG__45__RXN" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PUT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__4__45__HYDROXY__45__PROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOINASE__45__RXN" name="Allantoinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DAL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allantoinase )</html:p>
<html:p>SUBSYSTEM: allantoin degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLANTOIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOLICHYLDIPHOSPHATASE__45__RXN" name="Dolichyldiphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CAX4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CAX4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.43</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__224" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICONUCADENYLYLTRAN__45__RXN" name="Nicotinate-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NMA1 ) or ( NMA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nicotinamide/nicotinic acid mononucleotide adenylyltransferase ) or ( Nicotinamide/nicotinic acid mononucleotide adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: de novo NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__15__45__RXN" name="Cholinephosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PCT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphorylcholine transferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis (Kennedy pathway)</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.15</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADP_TO_NADPH_COF_RXN" name="NADP_TO_NADPH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UREA__45__CARBOXYLASE__45__RXN" name="Urea carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DUR1,2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: allantoin degradation</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__578" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__13__45__RXN" name="Mannose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PSA1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="CPD__45__489" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4941" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( KCS1 ) or ( ARG82 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: inositol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIPHOSPHO__45__1D__45__MYO__45__INOSITOL__45__TETRAKISPHOSPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UTPHEXPURIDYLYLTRANS__45__RXN" name="UTP--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GAL7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GAL7 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYRIBONUCSYN__45__RXN" name="Phosphoribosylamine--glycine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE5,7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="PRA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYSYN__45__RXN" name="Phosphatidate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CDS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.41</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFATE__45__ADENYLYLTRANS__45__RXN" name="Sulfate adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MET3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP sulfurylase )</html:p>
<html:p>SUBSYSTEM: sulfate assimilation pathway</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.4</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALISOM__45__RXN" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LEU1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopropylmalate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERONE__45__KINASE__45__RXN" name="Glycerone kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DAK2 ) or ( DAK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxyacetone kinase ) or ( dihydroxyacetone kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.29</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMHYDR__45__RXN" name="Fumarate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FUM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarate hydralase )</html:p>
<html:p>SUBSYSTEM: superpathway of TCA cycle and glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle, aerobic respiration</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__13__46__11__46__6__45__RXN" name="3-hydroxyanthranilate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BNA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyanthranilic acid dioxygenase )</html:p>
<html:p>SUBSYSTEM: de novo NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan degradation via kynurenine</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.6</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LSERINEDEAM__45__RXN" name="L-serine dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine/threonine dehydratase )</html:p>
<html:p>SUBSYSTEM: L-serine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.13</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOSE__45__EPIMERASE__45__RXN" name="Aldose 1-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GAL10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: galactose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRIBFAICARPISOM__45__RXN" name="N-(5&apos;-phospho-D-ribosylformimino)-5-amino-1-(5&apos;&apos;-phosphoribosyl)-4- imidazole carboxamide isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIS6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Sterol O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARE2 ) or ( ARE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA cholesterol acyltransferase ) or ( acyl-CoA cholesterol acyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.26</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLESTEROL_ESTER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ANTHRANSYN__45__RXN" name="Anthranilate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TRP2 and TRP3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA and NA )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.27</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__LYASE__45__RXN" name="Cystathionine beta-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STR3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-lyase )</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.8</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PGS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylglycerolphosphate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.5</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRS__45__RXN" name="Phosphoribosylformylglycinamidine cyclo-ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE5,7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROPRIBTRANS__45__RXN" name="Orotate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URA10 ) or ( URA5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( orotate phosphoribosyltransferase ) or ( orotate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__REDUCT__45__RXN" name="Sulfite reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET5 and MET10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta subunit and alpha subunit )</html:p>
<html:p>SUBSYSTEM: sulfate assimilation pathway</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA_TO_CO__45__A_COF_RXN" name="ACYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PURIDYLTRANS__45__RXN" name="UTP--glucose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UGP1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridinephosphoglucose pyrophosphorylase ) or ( UTP glucose-1-phosphate uridylyltransferase )</html:p>
<html:p>SUBSYSTEM: dolichyl glucosyl phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__14__45__RXN" name="Ethanolamine-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MUQ1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoethanolamine cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II (Kennedy pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.14</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FOLYLPOLYGLUTAMATESYNTH__45__RXN" name="Folylpolyglutamate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MET7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthetase )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BAT2 ) or ( BAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid transaminase ) or ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: leucine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, isoleucine, and valine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SQUALENE__45__MONOOXYGENASE__45__RXN" name="Squalene monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene monooxygenase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__229" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__17__45__RXN" name="Phosphatidylethanolamine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CHO2 )</html:p>
<html:p>SUBSYSTEM: superpathway of phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidic acid and phospholipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.17</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__405" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SFA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.284</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSTEINE__45__S__45__METHYLTRANSFERASE__45__RXN" name="Homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MHT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-Methylmethionine Homocysteine methylTransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.10</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GART__45__RXN" name="Phosphoribosylglycinamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADE8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycinamide ribotide transformylase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of purine nucleotides</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of purine biosynthesis and salvage pathways</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.2</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXY__45__KYNURENINASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BNA5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Kynureninase )</html:p>
<html:p>SUBSYSTEM: de novo NAD biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan degradation via kynurenine</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAMDECARB__45__RXN" name="Adenosylmethionine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SPE2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: spermine and methylthioadenosine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine salvage pathway</html:p>
<html:p>SUBSYSTEM: spermidine and methylthioadenosine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.50</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAPOXNPHOSPHN__45__RXN" name="Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TDH3 ) or ( TDH2 ) or ( TDH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyceraldehyde-3-phosphate dehydrogenase ) or ( glyceraldehyde 3-phosphate dehydrogenase ) or ( glyceraldehyde-3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glycolysis</html:p>
<html:p>SUBSYSTEM: superpathway of glucose fermentation</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD_TO_FADH2_COF_RXN" name="FAD_TO_FADH2_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FADH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.22</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
