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<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="TBRUCEI_metabolic_network_metabolic_network" name="Trypanosoma brucei">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
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  <species id="NADPH" name="NADPH" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROPIONATE" name="propionate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HEME_O" name="heme o" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__313" name="1,3-diaminopropane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAMINE__45__5P" name="pyridoxamine 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7221" name="3-cis-dodecenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7222" name="2-trans-dodecenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FAD" name="FAD" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7224" name="N-acetyl-L-citrulline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__C__45__TERMINAL__45__S__45__ETC__45__CYSTEINE" name="protein c-terminal s-farnesyl-l-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GAMMA__45__GLUTAMYLCYSTEINE" name="L-&amp;gamma;-glutamylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="EPOXYSQUALENE" name="(S)-2,3-epoxysqualene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP" name="GDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" name="an L-1-phosphatidylglycerol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" name="an L-1-phosphatidyl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SEDOHEPTULOSE__45__7__45__P" name="D-sedoheptulose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROFOLATE" name="7,8-dihydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acceptor__124__" name="an oxidized electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ILE" name="L-isoleucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__PG" name="2-phosphoglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINAMINE" name="S-adenosyl-L-methioninamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z13E__45__15S__45__9__45__ALPHA11__45__ALPHA15__45__TRIHY" name="(5z,13e)-(15s)-9-&amp;alpha;,11-&amp;alpha;,15-trihydroxyprosta-5,13-dienoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARG" name="L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOHEME" name="protoheme IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__ACYL__45__2__45__OLEOYL__45__SN__45__GLYCERO__45__3__45__PHOSPHOCHOL" name="1-acyl-2-oleoyl-sn-glycero-3-phosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMP" name="inosine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__METHYL__45__1__45__246__45__TRIHYDROXYPHENYLBUTAN" name="phlorisovalerophenone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__COA" name="acetyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GULONATE" name="L-gulonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NUC__45__5__45__PHOSPHATE" name="a nucleoside-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOAMIDE" name="lipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" name="formyl-L-methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ASN" name="L-asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ASPARTATE" name="L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__8" name="ubiquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__9" name="ubiquinone-9" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CYSTATHIONINE" name="cystathionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Donor__45__H2__124__" name="a reduced electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" name="(S)-1-pyrroline-5-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" name="D-myo-inositol (1,3,4)-trisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL" name="pyridoxal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" name="D-myo-inositol (3)-monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Diphosphates__124__" name="a ribonucleoside diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FE__43__3" name="Fe3+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FE__43__2" name="Fe2+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Long__45__Chain__45__Carboxylates__124__" name="a long chain carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6082" name="3-aminopropionaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__FORMYLMETHIONINE" name="N-formyl-L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__5P" name="D-ribose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATP" name="ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__trans__45__4__45__cis__45__dienoyl__45__CoAs__124__" name="a 2-trans-4-cis-dienoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSINE5TRIPHOSPHO5ADENOSINE" name="5&apos;,5&apos;-diadenosine triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Long__45__Chain__45__Polyphosphate__124__" name="long chain polyphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DI__45__H__45__OROTATE" name="dihydroorotate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Triacylglycerols__124__" name="a triacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NAD" name="NAD+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH__45__P__45__OR__45__NOP" name="NAD(P)H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__MANNOSE" name="GDP-&amp;alpha;-D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="T2__45__DECENOYL__45__COA" name="trans-&amp;Delta;2-decenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__TETRADECANOYLGLYCYL__45__PEPTIDE" name="N-tetradecanoylglycyl-peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCEROL__45__3P" name="sn-glycerol-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDPDIACYLGLYCEROL" name="a CDP-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__LACTATE" name="D-lactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRANS__45__D2__45__ENOYL__45__COA" name="a trans-2-enoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="URACIL" name="uracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8192" name="demethylsuberosin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" name="a 2,3,4-saturated fatty acyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7158" name="3-demethylubiquinol-9" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CANAVANINE" name="canavanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__PROPIONYL__45__COA" name="3-hydroxypropionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleotides__124__" name="a ribonucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__ISOBUTYRATE" name="3-hydroxy-isobutyrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__3__45__HYDROXYACYL__45__COA" name="a (3S)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SUC" name="succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HOMO__45__CYS" name="L-homocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" name="4,4-dimethyl-5-&amp;alpha;-cholesta-8,14,24-trien-3-&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__General__45__Phos__45__Protein__45__Substrates__124__" name="a phosphoprotein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THREO__45__DS__45__ISO__45__CITRATE" name="D-isocitrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8186" name="umbelliferone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENYLOSUCC" name="adenylo-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__L__45__Amino__45__Acids__124__" name="an L-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1301" name="tetrahydropteroyltri-L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1302" name="5-methyltetrahydropteroyltri-L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__40__ADP__45__D__45__RIBOSYL__41____40__N__41____45__ACCEPTOR" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__10227" name="1-deoxy-1-imino-D-erythrose 4-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUMP" name="dUMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__10226" name="3-amino-3-deoxy-D-fructose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NAD__45__P__45__OR__45__NOP" name="NAD(P)+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALO__45__SUCCINATE" name="oxalosuccinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="A__45__3__45__OXO__45__ACYL__45__COA" name="a 3-oxo-acyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1108" name="1-phosphatidyl-1D-myo-inositol 4-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CITRULLINE" name="citrulline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UNDECAPRENYL__45__DIPHOSPHATE" name="di-trans,poly-cis-undecaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__ACYL__45__2__45__LINOLEOYL__45__SN__45__GLYCERO__45__3__45__PHOSPHOC" name="1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="GLYCERATE" name="D-glycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__375" name="4-pyridoxolactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__L__45__1__45__phosphatidyl__45__inositols__124__" name="an L-1-phosphatidyl-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__MERCAPTO__45__PYRUVATE" name="3-mercaptopyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HSCN" name="thiocyanate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acyl__45__Phosphates__124__" name="an acyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__Hydroxy__45__carboxylates__124__" name="a 2-hydroxy carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XANTHINE" name="xanthine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1113" name="6-(&amp;alpha;-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LINOLEIC_ACID" name="linoleate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ALPHA__45__ACETYLORNITHINE" name="N-acetyl-L-ornithine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHYLENE__45__THF" name="5,10-methylene-THF" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BIOPTERIN" name="dihydrobiopterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TETRADEHYDROACYL__45__COA" name="a trans,trans-&amp;Delta;2-&amp;Delta;4-dienoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH" name="NADH" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INDOLEYL__45__CPD" name="indole-3-acetonitrile" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CYS" name="L-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AICAR" name="aminoimidazole carboxamide ribonucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSINE" name="adenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADP" name="NADP+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Hexoses__124__" name="a D-hexose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXY__45__ACETONE__45__PHOSPHATE" name="dihydroxyacetone phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC" name="&amp;beta;-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SQUALENE" name="squalene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__THF__45__GLU__45__N" name="an N10-formyl-tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Carboxylates__124__" name="a carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__190" name="N-acetylglucosaminyl-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRAZINAMIDE" name="pyrazinamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__782" name="3,4-dihydroxyphenylacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__hydroxyacyl__45__glutathiones__124__" name="S-(2-hydroxyacyl)glutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__195" name="octanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1137" name="itaconyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__SULFINYL__45__PYRUVATE" name="3-sulfinyl-pyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAMINE" name="pyridoxamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__397" name="S-methyl-L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HOMO__45__SER" name="homoserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__678" name="selenide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_34__45__DIHYDROXYPHENYLACETALDEHYDE" name="3,4-dihydroxyphenylacetaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORYL__45__ETHANOLAMINE" name="phosphoryl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__PHOSPHATIDATE" name="an L-phosphatidate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Quinones__124__" name="a quinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Fatty__45__Acids__124__" name="a fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3945" name="(22&amp;alpha;)-hydroxy-campest-4-en-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="CPD__45__3946" name="(22&amp;alpha;)-hydroxy-5&amp;alpha;-campestan-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__698" name="campest-4-en-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__696" name="24-methylenecycloartenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__499" name="mevalonate-5P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="VAL" name="L-valine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="CIS__45__DELTA3__45__ENOYL__45__COA" name="a cis-3-enoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP" name="UDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HCO3" name="bicarbonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TDP" name="dTDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Purine__45__Bases__124__" name="a purine base" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="CPD__45__665" name="propanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NIACINAMIDE" name="nicotinamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACYL__45__COA" name="an acyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__465" name="presqualene diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHO__45__ENOL__45__PYRUVATE" name="phosphoenolpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DELTA3__45__ISOPENTENYL__45__PP" name="isopentenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OROTIDINE__45__5__45__PHOSPHATE" name="orotidine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRUCTOSE__45__16__45__DIPHOSPHATE" name="fructose-1,6-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Fatty__45__Aldehydes__124__" name="a fatty aldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHOLINE" name="choline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="DCTP" name="dCTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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</listOfSpecies>
<listOfReactions>
  <reaction id="AKBLIG__45__RXN" name="Glycine C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine acetyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: threonine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.29</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREODEHYD__45__RXN" name="L-threonine 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-threonine 3-dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: threonine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.103</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__45__PHOSPHATIDYLINOSITOL__45__KINASE__45__RXN" name="1-phosphatidylinositol 4-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 4-kinase alpha, putative ) or ( phosphatidylinositol 4-kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.67</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDHDEHYDROG__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family, putative ) or ( aldehyde dehydrogenase, putative ) or ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANOSINE__45__DIPHOSPHATASE__45__RXN" name="Guanosine-diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanosine diphosphatase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.42</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16ALDOLASE__45__RXN" name="Fructose-bisphosphate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-bisphosphate aldolase, glycosomal )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-8 sterol isomerase, putative )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4081" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4101" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENETHFDEHYDROG__45__NADP__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-1-tetrahydrofolate synthase, cytoplasmic, putative )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCGLUALDDEHYD__45__RXN" name="Succinylglutamate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.71</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__SUCCINYLGLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__198__45__RXN" name="Phosphatidylinositol N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositolN- acetylglucosaminyltransferase subunit c, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.198</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__452" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKYLGLYCERONE__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="Alkylglycerone-phosphate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alkylglycerone-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.26</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__a__45__long__45__chain__45__alcohol__124__" stoichiometry="1"/>
      <speciesReference species="_1__45__ACYL__45__GLYCERONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="_1__45__ALKYL__45__GLYCERONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTOX__45__RXN" name="Dihydroorotate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotate oxidase, putative )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__3__45__PHOSPHATE__45__DEHYDROGENASE__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase (FAD-dependent), putative ) or ( glycerol-3-phosphate dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDYLCHOLINE__45__DESATURASE__45__RXN" name="Phosphatidylcholine desaturase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oleate desaturase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__ACYL__45__2__45__OLEOYL__45__SN__45__GLYCERO__45__3__45__PHOSPHOCHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__ACYL__45__2__45__LINOLEOYL__45__SN__45__GLYCERO__45__3__45__PHOSPHOC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSALDOL__45__RXN" name="Transaldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transaldolase, putative )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP_TO_GDP_COF_RXN" name="GTP_TO_GDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate-dihydrofolate synthetase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__A1__45__RXN" name="Phospholipase A1" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase A1 )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.32</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINE__45__NUCLEOSIDASE__45__RXN" name="Uridine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uracil-DNA glycosylase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM2__45__RXN" name="Cytidine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase, putative )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__188__45__RXN" name="prostaglandin-F synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostaglandin f synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.188</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5Z13E__45__15S__45__9__45__ALPHA11__45__ALPHA15__45__TRIHY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__15S__45__9__45__ALPHA15__45__DIHYDROXY__45__11__45__O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__271__45__RXN" name="GDP-L-fucose synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-L-fucose synthetase, putative )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.271</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTODEXGLUCOSID__45__RXN" name="&amp;alpha;-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosidase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4144" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-14 sterol reductase, putative )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATE__45__REDUCTASE__45__NADH__45__RXN" name="nitrate reductase (NADH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrate reductase, putative )</html:p>
<html:p>SUBSYSTEM: nitrate reduction II (assimilatory)</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family, putative ) or ( aldehyde dehydrogenase, putative ) or ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase, putative ) or ( branched-chain amino acid aminotransferase, putative )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FERRIC__45__CHELATE__45__REDUCTASE__45__RXN" name="Ferric-chelate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferric reductase, putative; ferric reductase transmembrane component, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.16.1.7</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FE__43__3" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FE__43__2" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTPDECARB__45__RXN" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( OMPDCase-OPRTase, putative )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.23</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXAL__45__4__45__DEHYDROGENASE__45__RXN" name="Pyridoxal 4-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxoacyl-(acyl-carrier protein) reductase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.107</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__375" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ICOSANOYL__45__COA__45__SYNTHASE__45__RXN" name="fatty acid elongase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acid elongase, putative ) or ( fatty acid elongase, putative ) or ( fatty acid elongase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.119</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="STEAROYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9965" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSPSYN__45__RXN" name="glutathionylspermidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathionylspermidine synthetase, putative )</html:p>
<html:p>SUBSYSTEM: glutathionylspermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONYLSPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROT__45__RXN" name="Dihydroorotase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotase, putative )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROG__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase (FAD-dependent), putative ) or ( glycerol-3-phosphate dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>SIDE: UBIQUINOL__45__8</html:p>
<html:p>SIDE: UBIQUINONE__45__8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERALDEHYDE__45__DEHYDRO__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family, putative ) or ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__34__45__RXN" name="Hydroxymethylglutaryl-CoA reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl-CoA reductase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHD__45__RXN" name="Choline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLPHOSPHATASE__45__RXN" name="Acylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acylphosphatase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acyl__45__Phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R222__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family, putative ) or ( aldehyde dehydrogenase, putative ) or ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__371" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__15__45__RXN" name="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine--dolichyl-phosphate n- acetylglucosaminephosphotransferase, putative )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.15</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="CPD__45__190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENMETSYN__45__RXN" name="Methionine adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine synthetase, putative ) or ( S-adenosylmethionine synthetase, putative ) or ( S-adenosylmethionine synthetase, putative ) or ( S-adenosylmethionine synthetase, putative ) or ( S-adenosylmethionine synthetase, putative ) or ( S-adenosylmethionine synthetase, putative ) or ( S-adenosylmethionine synthetase, putative ) or ( S-adenosylmethionine synthetase, putative ) or ( S-adenosylmethionine synthetase, putative )</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__SYN__45__RXN" name="glutathione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione synthetase, putative )</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__711" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxo-5-alpha-steroid 4-dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__698" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__709" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__100__45__RXN" name="Protein-S isoprenylcysteine O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyl protein specific carboxyl methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.100</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__ETC__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__FARNESYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LANOSTEROL__45__SYNTHASE__45__RXN" name="Lanosterol synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol synthase )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4229" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxo-5-alpha-steroid 4-dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3945" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3946" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHACYL__45__COA__45__DEHYDROG__45__RXN" name="3-hydroxyacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase/Enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATESYN__45__RXN" name="Thymidylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrofolate reductase-thymidylate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.45</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: DIHYDROFOLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="EXOPOLYPHOSPHATASE__45__RXN" name="Exopolyphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acidocalcisomal exopolyphosphatase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase, putative ) or ( nucleoside diphosphate kinase ) or ( nucleoside diphosphate kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOSINE__45__NUCLEOSIDASE__45__RXN" name="Inosine nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IAG-nucleoside hydrolase ) or ( nucleoside hydrolase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGANINE__45__1__45__PHOSPHATE__45__ALDOLASE__45__RXN" name="Sphinganine-1-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingosine phosphate lyase-like protein, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.27</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMITALDEHYDE" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DADP_TO_DATP_COF_RXN" name="DADP_TO_DATP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="DADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIPHOSPHATASE__45__RXN" name="Nucleoside-diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleoside triphosphate diphosphohydrolase 5, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" name="L-ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__69__45__RXN" name="N-acetylglucosaminylphosphatidylinositol deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosaminylphosphatidylinositoldeacety lase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.89</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__452" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__1113" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1404" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrilase, putative )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLEYL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OXOACID__45__COA__45__TRANSFERASE__45__RXN" name="3-oxoacid CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl-coA:3-ketoacid-coenzyme A transferase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__3__45__OXO__45__ACID" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="A__45__3__45__OXO__45__ACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP_TO_UTP_COF_RXN" name="UDP_TO_UTP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate-dihydrofolate synthetase, putative )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OMEGA__45__AMIDASE__45__RXN" name="&amp;omega;-amidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( metalloprotease-like protein; peptide deformylase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DICARBOXYLIC__45__ACID__45__MONOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__dicarboxylate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSMANMUT__45__RXN" name="Phosphomannomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomannomutase, putative )</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAZIN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrazinamidase/nicotinamidase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRAZINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRAZINOIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__37" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family, putative ) or ( aldehyde dehydrogenase, putative ) or ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__30" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__35" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__34" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPRIBOSYLTRAN__45__RXN" name="Adenine phosphoribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenine phosphoribosyltransferase, putative ) or ( adenine phosphoribosyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1603" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__409" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__504" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_DIHYDROFOLATE_COF_RXN" name="METHYLENE-THF_TO_DIHYDROFOLATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPRIBOSYLTRAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine-guanine phosphoribosyltransferase ) or ( hypoxanthine-guanine phosphoribosyltransferase, putative ) or ( hypoxanthine-guanine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERCAPYSTRANS__45__RXN" name="3-mercaptopyruvate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mercaptopyruvate sulfurtransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCN" stoichiometry="1"/>
      <speciesReference species="_3__45__MERCAPTO__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HSCN" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__21__45__RXN" name="Farnesyl-diphosphate farnesyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene synthase, putative ) or ( protein farnesyltransferase beta subunit )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDYLATE__45__SYNTHASE__45__RXN" name="Pseudouridylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA pseudouridine synthase A, putative ) or ( RNA pseudouridylate synthase protein, putative ) or ( tRNA pseudouridine synthase, putative ) or ( hypothetical protein, conserved ) or ( pseudouridylate synthase I, putative ) or ( pseudouridylate synthase, putative ) or ( pseudouridine synthase A-like protein, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.70</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIACYLGLYCEROL__45__LIPASE__45__RXN" name="Triacylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipase-like protein, putative ) or ( lipase, putative )</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Fatty__45__Acids__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Diacylglycerides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__DELTA__45__ISOM__45__RXN" name="Dodecenoyl-CoA &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative ) or ( 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative ) or ( 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__DELTA3__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__12__45__RXN" name="cGMP-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; glycogen synthase kinase, putative ) or ( protein kinase, putative ) or ( cell division related protein kinase 2, putative; CDC2-related protein kinase ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( cell division protein kinase 2 homolog 1; cdc2- like protein kinase ) or ( glycogen synthase kinase-3 alpha, putative ) or ( protein kinase, putative ) or ( NIMA-related protein kinase ) or ( protein kinase, putative ) or ( cell division control protein 2 homolog 4 ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( serine/threonine-protein kinase NrkA ) or ( serine/threonine-protein kinase, putative ) or ( casein kinase II, alpha chain ) or ( protein kinase B kinase, putative ) or ( protein kinase, putative; serine/threonine- protein kinase nek1, putative ) or ( protein kinase A catalytic subunit ) or ( nek1/NIMA-related kinase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBPSYN__45__RXN" name="carbamoyl-phosphate synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine-fructose-6-phosphate aminotransferase, putative )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.16</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__HYDRAT__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PALMITYL__45__COA_TO_CO__45__A_COF_RXN" name="PALMITYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PALMITYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__218" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-5 sterol desaturase, putative )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPISTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_572428__45__ERGOSTATRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__11__45__RXN" name="cAMP-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; glycogen synthase kinase, putative ) or ( protein kinase, putative ) or ( cell division related protein kinase 2, putative; CDC2-related protein kinase ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( cell division protein kinase 2 homolog 1; cdc2- like protein kinase ) or ( glycogen synthase kinase-3 alpha, putative ) or ( protein kinase, putative ) or ( NIMA-related protein kinase ) or ( protein kinase, putative ) or ( cell division control protein 2 homolog 4 ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( serine/threonine-protein kinase NrkA ) or ( serine/threonine-protein kinase, putative ) or ( casein kinase II, alpha chain ) or ( protein kinase B kinase, putative ) or ( protein kinase, putative; serine/threonine- protein kinase nek1, putative ) or ( protein kinase A catalytic subunit ) or ( nek1/NIMA-related kinase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__PEROXIDASE__45__RXN" name="glutathione peroxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trypanothione/tryparedoxin dependent peroxidase 1, cytosolic; glutathione peroxidase-like protein 1 ) or ( trypanothione/tryparedoxin dependent peroxidase 2; glutathione peroxidase-like 2 ) or ( glutathione peroxidase, putative ) or ( trypanothione/tryparedoxin dependent peroxidase 3; glutathione peroxidase-like protein 3 )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.9</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__22__45__RXN" name="Cyclin-dependent kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; glycogen synthase kinase, putative ) or ( protein kinase, putative ) or ( cell division related protein kinase 2, putative; CDC2-related protein kinase ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( cell division protein kinase 2 homolog 1; cdc2- like protein kinase ) or ( glycogen synthase kinase-3 alpha, putative ) or ( protein kinase, putative ) or ( NIMA-related protein kinase ) or ( protein kinase, putative ) or ( cell division control protein 2 homolog 4 ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( serine/threonine-protein kinase NrkA ) or ( serine/threonine-protein kinase, putative ) or ( casein kinase II, alpha chain ) or ( protein kinase B kinase, putative ) or ( protein kinase, putative; serine/threonine- protein kinase nek1, putative ) or ( protein kinase A catalytic subunit ) or ( nek1/NIMA-related kinase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.22</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol 14-alpha-demethylase; cytochrome P450 51A1 )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4573" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol 14-alpha-demethylase; cytochrome P450 51A1 )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4568" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4573" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol 14-alpha-demethylase; cytochrome P450 51A1 )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4568" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITDEH__45__RXN" name="Isocitrate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate dehydrogenase, putative ) or ( isocitrate dehydrogenase [NADP], mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THRESYN__45__RXN" name="Threonine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine synthase, putative )</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__306" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-14 sterol reductase, putative )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__56__45__RXN" name="Inositol-1,4,5-trisphosphate 5-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-acyl-sn-glycerol-3-phosphate acyltransferase protein, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.51</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7810" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__7109" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7105" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA__45__CARBOXYLTRANSFER__45__RXN" name="Acetyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA carboxylase, putative )</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis initiation (E. coli)</html:p>
<html:p>SUBSYSTEM: fatty acid biosynthesis initiation I</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7811" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="_3__45__METHYL__45__1__45__246__45__TRIHYDROXYPHENYLBUTAN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7109" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7812" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: hyperforin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__7104" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__PRENYLPHLORISOBUTYROPHENONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase, putative ) or ( branched-chain amino acid aminotransferase, putative )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7813" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: hyperforin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__PRENYLPHLORISOBUTYROPHENONE" stoichiometry="1"/>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase, putative ) or ( nucleoside diphosphate kinase ) or ( nucleoside diphosphate kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP__45__MANNOSE_TO_GDP_COF_RXN" name="GDP-MANNOSE_TO_GDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDATE__45__PHOSPHATASE__45__RXN" name="Phosphatidate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidic acid phosphatase alpha, putative ) or ( phosphatidic acid phosphatase, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5467" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannosyltransferase )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
      <speciesReference species="CPD__45__5165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__11__45__RXN" name="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol synthase, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.11</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5469" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannosyltransferase )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5167" stoichiometry="1"/>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5168" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__PALMITOYLTRANSFERASE__45__RXN" name="Carnitine O-palmitoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine O-palmitoyltransferase, putative ) or ( carnitine O-palmitoyltransferase II, putative ) or ( carnitine O-palmitoyltransferase II, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.21</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PALMITYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__419" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannosyltransferase )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.132</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__MANNOSYLCHITOBIO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5161" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5463" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannosyltransferase )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5161" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5162" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxyisobutyrate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxy-3-oxopropionate reductase, putative )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.31</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BHBDCLOS__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase/Enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Carnitine O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine O-acetyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.7</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__ACETYLCARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5398" name="Pseudouridylate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pseudouridylate synthase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__42__45__RXN" name="Glycerone-phosphate O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxyacetone phosphate acyltransferase, putative; glycerol-3-phosphate acyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.42</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__415" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGINASE__45__RXN" name="Arginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase, putative )</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGININE__45__KINASE__45__RXN" name="Arginine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginine kinase ) or ( arginine kinase ) or ( arginine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.3.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLATECYC__45__RXN" name="Adenylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( receptor-type adenylate cyclase GRESAG 4, putative; expression site-associated gene 4 (ESAG4) protein, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( chrIX additional, unordered contigs ) or ( receptor-type adenylate cyclase GRESAG 4, putative; receptor-type adenylate cyclase GRESAG 4.4B ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( expression site-associated gene (ESAG) protein, putative; expression site-associated gene 4 (ESAG4) protein, putative; receptor-type adenylate cyclase, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative; ESAG 4 (expression site-associated gene 4) protein, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( ATP pyrophosphate-lyase, putative ) or ( expression site-associated gene 4 (ESAG4) protein, putative; expression site-associated gene (ESAG) protein, putative; receptor-type adenylate cyclase ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( ATP pyrophosphate-lyase, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( expression site-associated gene 4 (ESAG4) protein, putative; expression site-associated gene 4 (ESAG4) protein, putative; receptor-type adenylate cyclase ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( ATP pyrophosphate-lyase, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( adenylyl cyclase, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative ) or ( receptor-type adenylate cyclase GRESAG 4, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LCYSDESULF__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathione gamma lyase, putative )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__11__45__RXN" name="1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoinositide-specific phospholipase C, putative )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIB5PISOM__45__RXN" name="Ribose 5-phosphate epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose 5-phosphate isomerase, putative )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="YEAST__45__SQUALENE__45__RXN" name="Farnesyl-diphosphate farnesyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene synthase, putative ) or ( protein farnesyltransferase beta subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IPPISOM__45__RXN" name="Isopentenyl-diphosphate &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopentenyl-diphosphate delta-isomerase, putative; isomerase, putative )</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINEPHOSPHOTRANSFERASE__45__RXN" name="Ethanolaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ethanolaminephosphotransferase, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.1</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPOXANPRIBOSYLTRAN__45__RXN" name="Hypoxanthine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine-guanine phosphoribosyltransferase ) or ( hypoxanthine-guanine phosphoribosyltransferase, putative ) or ( hypoxanthine-guanine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSGLYPHOS__45__RXN" name="Phosphoglycerate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate kinase ) or ( phosphoglycerate kinase, putative ) or ( phosphoglycerate kinase ) or ( phosphoglycerate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__23__45__RXN" name="Acylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monoglyceride lipase, putative ) or ( monoglyceride lipase, putative )</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Fatty__45__Acids__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__504" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__320" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-8 sterol isomerase, putative )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7835" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dienoyl-coa reductase-like protein )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__trans__45__4__45__cis__45__dienoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7931" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative ) or ( 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative ) or ( 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7221" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7836" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative ) or ( 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative ) or ( 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONDEHYDROG__45__RXN" name="Phosphogluconate dehydrogenase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase, decarboxylating, putative )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTPSYN__45__RXN" name="CTP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine triphosphate synthase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7838" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cis__45__2__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7933" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( metallo-peptidase, Clan MH, Family M18 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7224" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNDEACET__45__RXN" name="Acetylornithine deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( metallo-peptidase, Clan MH, Family M18 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__GLN__45__RXN" name="NAD(+) synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+ synthase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLTHFGLUSYNTH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate-dihydrofolate synthetase, putative )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOACYLASE__45__RXN" name="Aminoacylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acyl-L-amino acid amidohydrolase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.14</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Acylated__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__L__45__Amino__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__70__45__RXN" name="Sterol 14-demethylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol 14-alpha-demethylase; cytochrome P450 51A1 )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OBTUSIFOLIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANINE__45__DEAMINASE__45__RXN" name="Guanine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine aminohydrolase, putative )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYL__45__KIN__45__RXN" name="Guanylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanylate kinase, putative ) or ( guanylate kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Acceptor__124___TO___124__Donor__45__H2__124___COF_RXN" name="|Acceptor|_TO_|Donor-H2|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Aldehyde dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.4</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMP__45__DEHYDROG__45__RXN" name="IMP dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine-5&apos;-monophosphate dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.205</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MMUM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homocysteine S-methyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="CPD__45__397" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7908" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pterin-4-alpha-carbinolamine dehydratase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.96</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8783" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GULONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__9__46__3__45__RXN" name="Selenide,water dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( selenophosphate synthetase, putative )</html:p>
<html:p>SUBSYSTEM: selenocysteine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__678" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SEPO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__PHOSPHOFRUCTO__45__2__45__KINASE__45__RXN" name="6-phosphofructo-2-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructo-2-kinase/fructose-2,6-biphospha ta se,putative ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphospha ta se,putative ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphospha ta se,putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.105</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__535" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3PGAREARR__45__RXN" name="Phosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like protein, putative ) or ( phosphoglycerate mutase protein, putative ) or ( 2,3-bisphosphoglycerate-independent phosphoglycerate mutase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase, putative ) or ( nucleoside diphosphate kinase ) or ( nucleoside diphosphate kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__C__45__PALMITOYLTRANSFERASE__45__RXN" name="Serine C-palmitoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine-palmitoyl-CoA transferase, putative ) or ( serine palmitoyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.50</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PALMITYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROSPHINGANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URACIL__45__PRIBOSYLTRANS__45__RXN" name="Uracil phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uracil phosphoribosyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEAMINASE__45__RXN" name="AMP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine monophosphate deaminase, putative; AMP deaminase, putative ) or ( AMP deaminase, putative ) or ( AMP deaminase, putative ) or ( AMP deaminase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPISOM__45__RXN" name="Mannose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomannose isomerase, putative )</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: D-mannose degradation</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ALPHA__45__ALANINE_TO_PYRUVATE_COF_RXN" name="L-ALPHA-ALANINE_TO_PYRUVATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7911" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dienoyl-coa reductase-like protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRADEHYDROACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7919" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacylglutathione hydrolase, putative; glyoxalase II ) or ( hydroxyacylglutathione hydrolase, putative; glyoxalase II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__hydroxyacyl__45__glutathiones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Hydroxy__45__carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPONTPRO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MEVALONATE__45__KINASE__45__RXN" name="Mevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mevalonate kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.36</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__47__45__RXN" name="Variant-surface-glycoprotein phospholipase C" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( VSG lipase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.14</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1113" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="_6__45__A__45__D__45__GLUCOSAMINYL__45__1D__45__MYO__45__INOSITOL__45__12" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DURIDKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine kinase, putative )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLCROTONYL__45__COA__45__CARBOXYLASE__45__RXN" name="Methylcrotonyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methylcrotonyl-CoA carboxylase alpha subunit, putative ) or ( 3-methylcrotonoyl-CoA carboxylase beta subunit, putative )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PFRUCTPHOS__45__RXN" name="6-phosphofructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phospho-1-fructokinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACID__45__PHOSPHATASE__45__RXN" name="Acid phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acid phosphatase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__SYNTHASE__45__RXN" name="Cystathionine &amp;beta;-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-synthase, putative )</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis/homocysteine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINOALANINE__45__AMINOTRANSFERASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate aminotransferase, mitochondrial ) or ( aspartate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.1</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__17__45__RXN" name="3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&apos;, 5&apos;-cyclic nucleotide phosphodiesterase, putative ) or ( 3&apos;, 5&apos;-cyclic nucleotide phosphodiesterase, putative ) or ( 3&apos;, 5&apos;-cyclic nucleotide phosphodiesterase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__3__45__5__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NUC__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLT_TO_GLN_COF_RXN" name="GLT_TO_GLN_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOTHENATE__45__KIN__45__RXN" name="Pantothenate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantothenate kinase subunit, putative )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETRA__45__H__45__BIOPTERIN_TO_BIOPTERIN_COF_RXN" name="TETRA-H-BIOPTERIN_TO_BIOPTERIN_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLACYLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__57__45__RXN" name="Inositol-1,4-bisphosphate 1-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate 1-phosphatase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.57</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__MYO__45__INOSITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNA__45__RXN" name="Aspartate--ammonia ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine synthetase a, putative )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine.</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase, putative )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1685" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase ) or ( hexokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-galactose 4-epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__64__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-demethylubiquinone-9 3-methyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9957" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5408" name="Myo-inositol-1(or 4)-monophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol-1(or 4)-monophosphatase 1, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__MYO__45__INOSITOL__45__1__45__MONOPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNI__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl-coA:3-ketoacid-coenzyme A transferase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRNA__45__PSEUDOURIDINE__45__SYNTHASE__45__I__45__RXN" name="tRNA-pseudouridine synthase I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pseudouridylate synthase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8538" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8537" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R81__45__RXN" name="Hexokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase ) or ( hexokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYCEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Diacylglycerol O-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diacylglycerol acyltransferase, putative ) or ( diacylglycerol acyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: wax esters biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.20</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_ADP_COF_RXN" name="ATP_TO_ADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEPHOSPHOCOAKIN__45__RXN" name="Dephospho-CoA kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dephospho-CoA kinase, putative )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__11__46__1__46__15__45__RXN" name="Peroxiredoxin" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryparedoxin peroxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="2"/>
      <speciesReference species="__124__Alkyl__45__Hydro__45__Peroxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCISOM__45__RXN" name="Glucose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate isomerase, glycosomal )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__70__45__RXN" name="&amp;delta;(14)-sterol reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-14 sterol reductase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMET__45__RXN" name="5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-methyltetrahydropteroyltriglutamate--homocyst ei neS-methyltransferase,putative )</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.14</html:p>
<html:p>SIDE: CPD__45__1301</html:p>
<html:p>SIDE: CPD__45__1302</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1302" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1301" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__97__45__RXN" name="Glycylpeptide N-tetradecanoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-myristoyl transferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.97</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRADECANOYL__45__COA" stoichiometry="1"/>
      <speciesReference species="GLYCYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__TETRADECANOYLGLYCYL__45__PEPTIDE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMARATE__45__REDUCTASE__45__NADH__45__RXN" name="Fumarate reductase (NADH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH-dependent fumarate reductase ) or ( NADH-dependent fumarate reductase, putative ) or ( NADH-dependent fumarate reductase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.6</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITSYN__45__RXN" name="Citrate (si)-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( citrate synthase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYKI__45__RXN" name="Thymidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine kinase, putative )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__1__46__12__45__RXN" name="Trypanothione-disulfide reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trypanothione reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.12</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPANOTHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRYPANOTHIONE__45__DISULFIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULP3EPIM__45__RXN" name="ribulose phosphate 3-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribulose-5-phosphate 3-epimerase, putative )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__5__46__1__45__RXN" name="Nitrilase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrilase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nitriles__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__178" name="&amp;delta;(24)-sterol C-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chrX additional, unordered contigs ) or ( sterol 24-c-methyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.41</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FECOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINKIN__45__RXN" name="ATP-dependent riboflavin kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( riboflavin kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Fatty__45__Acyl__45__CoA__124___TO_CO__45__A_COF_RXN" name="|Fatty-Acyl-CoA|_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16BDEPHOS__45__RXN" name="Fructose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-1,6-bisphosphatase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPMANDEHYDRA__45__RXN" name="GDP-mannose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-mannose 4,6 dehydratase, putative )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: GDP-&amp;alpha;-D-perosamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.47</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEHYDR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDDEHYDROG__45__RXN" name="Lactaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family, putative ) or ( aldehyde dehydrogenase, putative ) or ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-D-GLUCOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__KINASE__45__RXN" name="Protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein kinase, putative ) or ( protein kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( protein kinase, putative ) or ( serine/threonine protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( serine/threonine protein kinase ) or ( protein kinase, putative; glycogen synthase kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative ) or ( cell division related protein kinase 2, putative; CDC2-related protein kinase ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( serine/threonine-protein kinase, putative ) or ( cell division protein kinase 2 homolog 1; cdc2- like protein kinase ) or ( glycogen synthase kinase-3 alpha, putative ) or ( protein kinase, putative ) or ( NIMA-related protein kinase ) or ( protein kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( serine/threonine protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( cell division control protein 2 homolog 4 ) or ( serine/threonine-protein kinase NrkA ) or ( serine/threonine-protein kinase, putative ) or ( casein kinase II, alpha chain ) or ( protein kinase B kinase, putative ) or ( protein kinase, putative; serine/threonine- protein kinase nek1, putative ) or ( protein kinase A catalytic subunit ) or ( nek1/NIMA-related kinase A ) or ( serine/threonine kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8730" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R223__45__RXN" name="long-chain-fatty-acid-CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acyl CoA synthetase 2 ) or ( fatty acyl CoA synthetase 4 ) or ( fatty acyl CoA synthetase, putative; Long-chain- fatty-acid--CoA ligase 4, putative ) or ( long-chain-fatty-acid-coA ligase protein,putative ) or ( fatty acyl CoA synthetase 3 ) or ( fatty acyl CoA syntetase 1 ) or ( long-chain-fatty acid-CoA ligase protein, putative; acyl-CoA synthetase, putative; fatty acid thiokinase (long chain), putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTANOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXKIN__45__RXN" name="Pyridoxal kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPPSYN__45__RXN" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl pyrophosphate synthetase, putative ) or ( prenyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: geranyldiphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIPHOSPHOMEVALONTE__45__DECARBOXYLASE__45__RXN" name="Diphosphomevalonate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mevalonate diphosphate decarboxylase ) or ( mevalonate diphosphate decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIP__45__KIN__45__RXN" name="Nucleoside-diphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase, putative ) or ( nucleoside diphosphate kinase ) or ( nucleoside diphosphate kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINAMID__45__RXN" name="Nicotinamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrazinamidase/nicotinamidase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__45__PHOSPHATIDYLINOSITOL__45__3__45__KINASE__45__RXN" name="1-phosphatidylinositol 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 3 kinase, putative ) or ( phosphatidylinositol 3-kinase, putative ) or ( phosphatidylinositol 3-kinase catalytic subunit, putative ) or ( phosphatidylinositol 3-kinase tor, putative ) or ( PI3-kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.137</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_ACETYL__45__COA_COF_RXN" name="CO-A_TO_ACETYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine desulfurase, putative ) or ( cysteine desulfurase, putative )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ENZYME__45__S__45__SULFANYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIOSEPISOMERIZATION__45__RXN" name="Triosephosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyceraldehyde-3-phosphate dehydrogenase, putative ) or ( triosephosphate isomerase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOVALERYL__45__COA__45__FAD__45__RXN" name="Isovaleryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isovaleryl-coA dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TIGLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDP_TO_CTP_COF_RXN" name="CDP_TO_CTP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIPHTHINE__45__SYNTHASE__45__RXN" name="Diphthine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diphthine synthase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.98</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__CARBOXY__45__3__45__AMINOPROPYL__45__L__45__HISTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__CARBOXY__45__3__45__METHYLAMMONIOPROPYL__45__L__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPDEPHOS__45__RXN" name="Pyruvate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate kinase 1 )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.40</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBDEHYDROG__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-1-pyrroline-5-carboxylate dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family, putative ) or ( aldehyde dehydrogenase, putative ) or ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QOR__45__RXN" name="NADPH:quinone reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxidoreductase, putative ) or ( oxidoreductase, putative ) or ( oxidoreductase, putative ) or ( oxidoreductase, putative ) or ( oxidoreductase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Semiquinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_GLT_COF_RXN" name="2-KETOGLUTARATE_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLU6PDEHYDROG__45__RXN" name="Glucose-6-phosphate 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate 1-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.49</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEAM__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathione gamma lyase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8642" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate dehydrogenase, putative ) or ( isocitrate dehydrogenase [NADP], mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__21__46__6__45__RXN" name="Lathosterol oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lathosterol oxidase, putative )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.6</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2141" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosidase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCC__45__FUM__45__OXRED__45__RXN" name="Succinate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__281" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene synthase, putative )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene monooxygenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSPAMID__45__RXN" name="glutathionylspermidine amidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trypanothione synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.78</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONYLSPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8631" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-bisphosphate aldolase, glycosomal )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine decarboxylase, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.65</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__130" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol 14-alpha-demethylase; cytochrome P450 51A1 )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__ATP__45__RXN" name="DNA ligase (ATP)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA ligase I, putative ) or ( DNA ligase, putative ) or ( mitochondrial DNA ligase homolog, putative ) or ( mitochondrial DNA ligase homolog, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGOMYELIN__45__PHOSPHODIESTERASE__45__RXN" name="Sphingomyelin phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sphingomyelin phosphodiesterase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.12</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sphingomyelins__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__13__45__RXN" name="Protein kinase C" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; glycogen synthase kinase, putative ) or ( protein kinase, putative ) or ( cell division related protein kinase 2, putative; CDC2-related protein kinase ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( cell division protein kinase 2 homolog 1; cdc2- like protein kinase ) or ( glycogen synthase kinase-3 alpha, putative ) or ( protein kinase, putative ) or ( NIMA-related protein kinase ) or ( protein kinase, putative ) or ( cell division control protein 2 homolog 4 ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( serine/threonine-protein kinase NrkA ) or ( serine/threonine-protein kinase, putative ) or ( casein kinase II, alpha chain ) or ( protein kinase B kinase, putative ) or ( protein kinase, putative; serine/threonine- protein kinase nek1, putative ) or ( protein kinase A catalytic subunit ) or ( nek1/NIMA-related kinase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARDIOLIPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cardiolipin synthetase, putative )</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>SIDE: GLYCEROL</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARDIOLIPIN" stoichiometry="1"/>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2301" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isovaleryl-coA dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATEPRIBOSYLTRANS__45__RXN" name="Nicotinate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate phosphoribosyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__21__45__RXN" name="Polo kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; glycogen synthase kinase, putative ) or ( protein kinase, putative ) or ( cell division related protein kinase 2, putative; CDC2-related protein kinase ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( cell division protein kinase 2 homolog 1; cdc2- like protein kinase ) or ( glycogen synthase kinase-3 alpha, putative ) or ( protein kinase, putative ) or ( NIMA-related protein kinase ) or ( protein kinase, putative ) or ( cell division control protein 2 homolog 4 ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( serine/threonine-protein kinase NrkA ) or ( serine/threonine-protein kinase, putative ) or ( casein kinase II, alpha chain ) or ( protein kinase B kinase, putative ) or ( protein kinase, putative; serine/threonine- protein kinase nek1, putative ) or ( protein kinase A catalytic subunit ) or ( nek1/NIMA-related kinase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PURINE__45__NUCLEOSIDASE__45__RXN" name="Purine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IAG-nucleoside hydrolase ) or ( nucleoside hydrolase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase, putative ) or ( nucleoside diphosphate kinase ) or ( nucleoside diphosphate kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYRIBOSE__45__P__45__ALD__45__RXN" name="Deoxyribose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyribose-phosphate aldolase, putative )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG1P__45__URIDYLTRANS__45__RXN" name="UDP-N-acetylglucosamine pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine pyrophosphorylase, putative )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.23</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__METHYLTHIOADENOSINE__45__PHOSPHORYLASE__45__RXN" name="5&apos;-methylthioadenosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylthioadenosine phosphorylase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="Myo-inositol-1(or 4)-monophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol-1(or 4)-monophosphatase 1, putative )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2750" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINE__45__KINASE__45__RXN" name="Ethanolamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline/ethanolamine kinase, putative ) or ( choline/ethanolamine kinase, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.82</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2751" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__41__45__RXN" name="Bis(5&apos;-nucleosyl)-tetraphosphatase (symmetrical)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kinetoplastid-specific phospho-protein phosphatase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.41</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__P4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTMPKI__45__RXN" name="Thymidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate kinase, putative ) or ( thymidylate kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__169" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3188" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosidase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__12__46__1__45__RXN" name="Dual-specificity kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; glycogen synthase kinase, putative ) or ( protein kinase, putative ) or ( cell division related protein kinase 2, putative; CDC2-related protein kinase ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( cell division protein kinase 2 homolog 1; cdc2- like protein kinase ) or ( glycogen synthase kinase-3 alpha, putative ) or ( protein kinase, putative ) or ( NIMA-related protein kinase ) or ( protein kinase, putative ) or ( cell division control protein 2 homolog 4 ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( serine/threonine-protein kinase NrkA ) or ( serine/threonine-protein kinase, putative ) or ( casein kinase II, alpha chain ) or ( protein kinase B kinase, putative ) or ( protein kinase, putative; serine/threonine- protein kinase nek1, putative ) or ( protein kinase A catalytic subunit ) or ( nek1/NIMA-related kinase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.12.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5180" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cis-prenyltransferase-like protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__46__45__RXN" name="Fructose-2,6-bisphosphate 2-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructo-2-kinase/fructose-2,6-biphospha ta se,putative ) or ( fructose-6-phosphate2-kinase, putative; fructose- 2,6- bisphosphatase-like protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__535" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATEORTHOPHOSPHATE__45__DIKINASE__45__RXN" name="Pyruvate,phosphate dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate phosphate dikinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTAGLY__45__RXN" name="Cystathionine &amp;gamma;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathione gamma lyase, putative )</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis/homocysteine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__61" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBREDUCT__45__RXN" name="Pyrroline-5-carboxylate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrroline-5-carboxylate reductase, putative )</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPCARBTRANS__45__RXN" name="Aspartate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate carbamoyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.2</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family, putative ) or ( aldehyde dehydrogenase, putative ) or ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation II (MEOS)</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__24__45__RXN" name="Mitogen-activated protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein kinase, putative ) or ( serine/threonine-protein kinase, putative ) or ( protein kinase, putative ) or ( mitogen-activated protein kinase 5 ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( mitogen-activated protein kinase 1, putative ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative ) or ( protein kinase, putative; glycogen synthase kinase, putative ) or ( mitogen-activated protein kinase 3, putative ) or ( protein kinase, putative ) or ( cell division related protein kinase 2, putative; CDC2-related protein kinase ) or ( protein kinase, putative ) or ( protein kinase, putative; (OTHER) NEK family, HsNEK1-like ) or ( cell division protein kinase 2 homolog 1; cdc2- like protein kinase ) or ( glycogen synthase kinase-3 alpha, putative ) or ( protein kinase, putative ) or ( NIMA-related protein kinase ) or ( protein kinase, putative ) or ( mitogen-activated protein kinase, putative ) or ( protein kinase, putative ) or ( cell division control protein 2 homolog 4 ) or ( protein kinase, putative ) or ( serine/threonine-protein kinase NrkA ) or ( serine/threonine-protein kinase, putative ) or ( casein kinase II, alpha chain ) or ( protein kinase B kinase, putative ) or ( protein kinase, putative; serine/threonine- protein kinase nek1, putative ) or ( protein kinase A catalytic subunit ) or ( nek1/NIMA-related kinase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIS5__45__ADENOSYL__45__TRIPHOSPHATASE__45__RXN" name="Bis(5&apos;-adenosyl)-triphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bis(5&apos;-adenosyl)-triphosphatase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.29</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE5TRIPHOSPHO5ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIENOYLCOAREDUCT__45__RXN" name="2,4-dienoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dienoyl-coa reductase-like protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="T2__45__DECENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="T2__45__C4__45__DECADIENYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6841" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase (FAD-dependent), putative ) or ( glycerol-3-phosphate dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="myo-inositol-1-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myo-inositol-1-phosphate synthase, putative )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NAD__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malic enzyme, putative ) or ( malic enzyme, putative )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.38</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXII__45__RXN" name="Hydroxyacylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacylglutathione hydrolase, putative; glyoxalase II ) or ( hydroxyacylglutathione hydrolase, putative; glyoxalase II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDYLINOSITOL__45__BISPHOSPHATASE__45__RXN" name="Phosphatidylinositol-bisphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( synaptojanin (N-terminal domain), putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.36</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMEOSYN__45__RXN" name="heme o biosynthesis" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoheme IX farnesyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEME_O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTCYSLIG__45__RXN" name="Glutamate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gcs1 or spac22f3.10C )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamylcysteine synthetase )</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADH__45__P__45__OR__45__NOP_TO_NAD__45__P__45__OR__45__NOP_COF_RXN" name="NADH-P-OR-NOP_TO_NAD-P-OR-NOP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMPSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__45__45__RXN" name="Homospermidine synthase (spermidine-specific)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyhypusine synthase, putative ) or ( deoxyhypusine synthase, putative )</html:p>
<html:p>SUBSYSTEM: homospermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.45</html:p>
<html:p>SIDE: CPD__45__313</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1821" stoichiometry="1"/>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPCOASYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-coa dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA__45__DECARBOXYLASE__45__RXN" name="Malonyl-CoA decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malonyl-CoA decarboxylase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSACETYLGLUCOSAMINEMUT__45__RXN" name="Phosphoacetylglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine-phosphate mutase, putative )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8945" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9375" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATEREDUCT__45__RXN" name="Dihydrofolate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrofolate reductase-thymidylate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8946" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__665" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPCARBOXYKIN__45__RXN" name="Phosphoenolpyruvate carboxykinase (ATP)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycosomal protein P60 )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.49</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM__45__RXN" name="Cytidine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase, putative )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOASYN__45__RXN" name="long-chain-fatty-acid--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acyl CoA synthetase 2 ) or ( fatty acyl CoA synthetase 4 ) or ( fatty acyl CoA synthetase, putative; Long-chain- fatty-acid--CoA ligase 4, putative ) or ( long-chain-fatty-acid-coA ligase protein,putative ) or ( fatty acyl CoA synthetase 3 ) or ( fatty acyl CoA syntetase 1 ) or ( long-chain-fatty acid-CoA ligase protein, putative; acyl-CoA synthetase, putative; fatty acid thiokinase (long chain), putative )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUTP__45__PYROP__45__RXN" name="dUTP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dUTP diphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.23</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOLACT__45__RXN" name="Gluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLMETHIONINE__45__DEFORMYLASE__45__RXN" name="Formylmethionine deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polypeptide deformylase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__FORMYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINASE__45__RXN" name="Adenosylhomocysteinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylhomocysteine hydrolase, putative )</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>PROTEIN_CLASS: 3.3.1.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2661" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( A/G-specific adenine glycosylase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__With__45__G__45__A__45__Mismatch__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__DNA__45__With__45__Mismatched__45__Adenine__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="adenylosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate synthetase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.4</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__8__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase [NAD+], glycosomal )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate isomerase, glycosomal )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEH__45__RXN" name="Malate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate dehydrogenase, putative ) or ( mitochondrial malate dehydrogenase ) or ( cytosolic malate dehydrogenase, putative ) or ( glycosomal malate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: aspartate degradation II</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.37</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__5" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family, putative ) or ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEXOKINASE__45__RXN" name="Hexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase ) or ( hexokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Hexoses__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__HEXOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__821" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline dehydrogenase )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOMEVALONATE__45__KINASE__45__RXN" name="Phosphomevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomevalonate kinase protein, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chrX additional, unordered contigs ) or ( sterol 24-c-methyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.41</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYCLOARTENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__696" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="ribose-phosphate diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose-phosphate pyrophosphokinase, putative ) or ( phosphoribosylpyrophosphate synthetase, putative ) or ( phosphoribosylpyrophosphate synthetase, putative ) or ( phosphoribosylpyrophosphate synthetase, putative )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RNA__45__LIGASE__45__ATP__45__RXN" name="RNA ligase (ATP)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mitochondrial RNA editing ligase 1; RNA-editing complex protein; RNA editing ligase; KREL1 ) or ( RNA editing ligase; RNA-editing complex protein; KREL2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleotides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__11" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol 14-alpha-demethylase; cytochrome P450 51A1 )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8606" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8607" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__12" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol 14-alpha-demethylase; cytochrome P450 51A1 )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8607" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8608" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__13" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol 14-alpha-demethylase; cytochrome P450 51A1 )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8608" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8609" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__16__45__RXN" name="Serine/threonine specific protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein phosphatase 2C, putative ) or ( protein phosphatase 2A, putative ) or ( protein phosphatase 2C, putative ) or ( PP1 ) or ( protein phosphatase 1, putative ) or ( protein phosphatase 2C, putative ) or ( protein phosphatase 1, putative ) or ( protein phosphatase 2B, putative ) or ( kinetoplastid-specific phospho-protein phosphatase, putative ) or ( protein phoshatase 1, putative ) or ( protein phosphatase 2C, putative ) or ( serine/threonine protein phosphatase 5 ) or ( protein phosphatase 2C, putative ) or ( protein phosphatase 2A, putative ) or ( protein phosphatase 2C, putative ) or ( protein phosphatase 2C, putative ) or ( ; protein phosphatase 2C, putative ) or ( protein phosphatase 2B, putative ) or ( protein phosphatase 4, putative ) or ( kinetoplastid-specific phospho-protein phosphatase, putative ) or ( protein phosphatase 1, putative ) or ( protein phosphatase 2C, putative ) or ( kinetoplastid-specific phospho-protein phosphatase, putative ) or ( protein phosphatase 2C, putative ) or ( kinetoplastid-specific phospho-protein phosphatase, putative ) or ( protein phosphatase 1, putative ) or ( protein phosphatase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.16</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamine amidotransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.2</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FPPSYN__45__RXN" name="geranyltranstransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl pyrophosphate synthetase, putative ) or ( farnesyl pyrophosphate synthase ) or ( prenyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARACHIDONATE__45____45__COA__45__LIGASE__45__RXN" name="Arachidonate--CoA ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( long-chain-fatty-acid-coA ligase protein,putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.15</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARACHIDONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAMKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase, decarboxylating, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__1__46__9__45__RXN" name="trypanothione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trypanothione synthetase ) or ( amidase, putative )</html:p>
<html:p>SUBSYSTEM: trypanothione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONYLSPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRYPANOTHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R9__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSINE__45__NUCLEOSIDASE__45__RXN" name="Adenosine nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IAG-nucleoside hydrolase ) or ( nucleoside hydrolase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate-dihydrofolate synthetase, putative )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOACYLCOATHIOL__45__RXN" name="Acetyl-CoA C-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-ketoacyl-CoA thiolase, putative )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.16</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD_TO_NADH_COF_RXN" name="NAD_TO_NADH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOKIN__45__RXN" name="Ribokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribokinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.15</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__68__45__RXN" name="1-phosphatidylinositol-4-phosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol-4-phosphate 5-kinase, putative ) or ( phosphatidylinositol-4-phosphate 5-kinase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.68</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9673" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acyl CoA synthetase 2 ) or ( fatty acyl CoA synthetase 4 ) or ( fatty acyl CoA synthetase, putative; Long-chain- fatty-acid--CoA ligase 4, putative ) or ( long-chain-fatty-acid-coA ligase protein,putative ) or ( fatty acyl CoA synthetase 3 ) or ( fatty acyl CoA syntetase 1 ) or ( long-chain-fatty acid-CoA ligase protein, putative; acyl-CoA synthetase, putative; fatty acid thiokinase (long chain), putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__18" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__25" name="Cholestenol &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-8 sterol isomerase, putative )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8621" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__26" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lathosterol oxidase, putative )</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.6</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8646" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2PGADEHYDRAT__45__RXN" name="Phosphopyruvate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enolase, putative ) or ( enolase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__7__45__RXN" name="Kynurenine--oxoglutarate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynurenine aminotransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.7</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__476" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase, putative )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__KIN__45__RXN" name="NAD(+) kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP-NAD kinase-like protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.23</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__TYROSINE__45__PHOSPHATASE__45__RXN" name="Protein-tyrosine-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein tyrosine phosphatase, putative ) or ( protein tyrosine phosphatase, putative ) or ( kinatase, putative ) or ( kinetoplastid-specific dual specificity phosphatase, putative ) or ( myotubularin, putative ) or ( kinetoplastod-specific dual specificity phosphatase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.48</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERSYN__45__RXN" name="CDP-diacylglycerol--serine O-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidyl serine synthase, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.8</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA_TO_CO__45__A_COF_RXN" name="MALONYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__88__45__RXN" name="Peptide deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polypeptide deformylase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.88</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINESYN__45__RXN" name="Spermidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine synthase, putative )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNDECARBOX__45__RXN" name="Ornithine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.17</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__363" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IAG-nucleoside hydrolase ) or ( nucleoside hydrolase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__KIN__45__RXN" name="Glycerol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol kinase, glycosomal ) or ( glycerol kinase, glycosomal ) or ( glycerol kinase, glycosomal ) or ( glycerol kinase, glycosomal ) or ( glycerol kinase, glycosomal )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.30</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9348" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9958" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__10" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9347" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9957" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__366" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IAG-nucleoside hydrolase ) or ( nucleoside hydrolase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERKIN__45__RXN" name="Homoserine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoserine kinase, putative )</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.39</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__83__45__RXN" name="Dolichyl-phosphate &amp;beta;-D-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dolichyl-phosphate beta-D-mannosyltransferase precursor, putative )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.83</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9644" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acyl CoA synthetase 2 ) or ( fatty acyl CoA synthetase 4 ) or ( fatty acyl CoA synthetase, putative; Long-chain- fatty-acid--CoA ligase 4, putative ) or ( long-chain-fatty-acid-coA ligase protein,putative ) or ( fatty acyl CoA synthetase 3 ) or ( fatty acyl CoA syntetase 1 ) or ( long-chain-fatty acid-CoA ligase protein, putative; acyl-CoA synthetase, putative; fatty acid thiokinase (long chain), putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OLEOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8988" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl-CoA synthetase alpha subunit, putative )</html:p>
<html:p>SUBSYSTEM: itaconate degradation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.4</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ITACONATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1137" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__15__45__RXN" name="Cholinephosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cholinephosphate cytidylyltransferase A, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.15</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADP_TO_NADPH_COF_RXN" name="NADP_TO_NADPH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINE__45__6__45__P__45__DEAMIN__45__RXN" name="Glucosamine-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine-6-phosphate isomerase, putative )</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__13__45__RXN" name="Mannose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannose-1-phosphate guanyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.13</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYSYN__45__RXN" name="phosphatidate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diacylglycerol synthetase, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.41</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOADEHYDROG__45__RXN" name="Acyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase, mitochondrial precursor, putative ) or ( acyl-coa dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCPDIESTER__45__RXN" name="Glycerophosphodiester phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerophosphoryl diester phosphodiesterase, putative )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.46</html:p>
<html:p>SIDE: __124__Alcohols__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycerophosphodiesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMHYDR__45__RXN" name="Fumarate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarate hydratase class I, putative ) or ( fumarate hydratase, putative )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9583" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="CPD__45__10226" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10227" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8999" name="di-trans-poly-cis-decaprenylcistransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cis-prenyltransferase-like protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9452" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylglycerophosphate synthase-like protein, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.5</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLPROLYL__45__ISOMERASE__45__RXN" name="Peptidylprolyl isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyclophilin, putative ) or ( cyclophilin type peptidyl-prolyl cis-trans isomerase, putative ) or ( peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin type peptidyl-prolyl cis-trans isomerase precursor, putative ) or ( cyclophilin type peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin, putative ) or ( cyclophilin type peptidyl-prolyl cis-trans isomerase, putative ) or ( hypothetical protein, conserved ) or ( peptidyl-prolyl cis-trans isomerase NIMA-interacting 4, putative ) or ( cyclophilin type peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin a; cyclophilin type peptidyl-prolyl cis-trans isomerase ) or ( cyclophilin-like protein, putative ) or ( peptidyl-prolyl cis-trans isomerase (cyclophilin- 40), putative; cyclophilin-40, putative ) or ( cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative ) or ( peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin type peptidyl-prolyl cis-trans isomerase, putative ) or ( peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin, putative ) or ( PPIase, putative ) or ( peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative ) or ( cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8625" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROPRIBTRANS__45__RXN" name="Orotate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( OMPDCase-OPRTase, putative )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9229" name="3-demethylubiquinone-9 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-demethylubiquinone-9 3-methyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9861" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9955" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA_TO_CO__45__A_COF_RXN" name="ACYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__5__45__RXN" name="3-oxo-5-&amp;alpha;-steroid 4-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxo-5-alpha-steroid 4-dehydrogenase, putative ) or ( 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Oxo__45__5__45__Alpha__45__Steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Oxo__45__Delta__45__4__45__Steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_SUC__45__COA_COF_RXN" name="CO-A_TO_SUC-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1026" name="fatty acid elongation" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acid elongase, putative ) or ( fatty acid elongase, putative ) or ( fatty acid elongase, putative )</html:p>
<html:p>SUBSYSTEM: wax esters biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VERY__45__LONG__45__CHAIN__45__FATTY__45__ACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PURIDYLTRANS__45__RXN" name="UTP--glucose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UTP-glucose-1-phosphate uridylyltransferase 2, putative )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__14__45__RXN" name="Ethanolamine-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ethanolamine-phosphate cytidylyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.14</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FOLYLPOLYGLUTAMATESYNTH__45__RXN" name="folylpolyglutamate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate-dihydrofolate synthetase, putative )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__LYASE__45__RXN" name="Hydroxymethylglutaryl-CoA lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxymethylglutaryl-CoA lyase, putative; 3- hydroxy-3-methylglutarate-CoA lyase, putative )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.4</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__43____45__ADP__45__RIBOSYLTRANSFERASE__45__RXN" name="NAD(+) ADP-ribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( poly(ADP-ribose) polymerase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.30</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__ADP__45__D__45__Ribosyl__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="__40__ADP__45__D__45__RIBOSYL__41____40__N__41____45__ACCEPTOR" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__ADP__45__D__45__Ribosyl__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="__40__ADP__45__D__45__RIBOSYL__41____40__N__43__1__41____45__ACCEPTOR" stoichiometry="1"/>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDLIPOXN__45__RXN" name="Dihydrolipoamide dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrolipoyl dehydrogenase ) or ( acetoin dehydrogenase e3 component, putative ) or ( dihydrolipoamide dehydrogenase, putative ) or ( dihydrolipoamide dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KYNURENINASE__45__RXN" name="Kynureninase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynureninase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase, putative ) or ( branched-chain amino acid aminotransferase, putative )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SEDOHEPTULOSE__45__BISPHOSPHATASE__45__RXN" name="Sedoheptulose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sedoheptulose-1,7-bisphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.37</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__1__45__7__45__P2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SQUALENE__45__MONOOXYGENASE__45__RXN" name="Squalene monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene monooxygenase, putative )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLGLUTACONYL__45__COA__45__HYDRATASE__45__RXN" name="Methylglutaconyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylglutaconyl-CoA hydratase, mitochondrial precursor, putative )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.18</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__8186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8192" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSTEINE__45__S__45__METHYLTRANSFERASE__45__RXN" name="Homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homocysteine S-methyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.10</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3443" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family, putative ) or ( aldehyde dehydrogenase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAMDECARB__45__RXN" name="Adenosylmethionine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine decarboxylase ) or ( S-adenosylmethionine decarboxylase ) or ( S-adenosylmethionine decarboxylaseregulator )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.50</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXY__45__KYNURENINASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynureninase, putative )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAPOXNPHOSPHN__45__RXN" name="Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyceraldehyde 3-phosphate dehydrogenase, glycosomal ) or ( glyceraldehyde 3-phosphate dehydrogenase, cytosolic ) or ( glyceraldehyde-3-phosphate dehydrogenase, putative ) or ( glyceraldehyde 3-phosphate dehydrogenase, glycosomal )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD_TO_FADH2_COF_RXN" name="FAD_TO_FADH2_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FADH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9237" name="3-demethylubiquinone-9 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-demethylubiquinone-9 3-methyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9873" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9958" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
