<?xml version="1.0"  encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="SODGM283_metabolic_network_metabolic_network" name="Sodalis glossinidius">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
  <species id="__124__Alpha__45__D__45__aldose__45__1__45__phosphates__124__" name="an &amp;alpha;-D-aldose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="B__45__ALANINE" name="&amp;beta;-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Glucose__124__" name="D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROPIONATE" name="propionate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADPH" name="NADPH" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HEME_O" name="heme o" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Monophosphates__124__" name="a ribonucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAMINE__45__5P" name="pyridoxamine 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1080" name="GlcNAc-1,6-anhMurNAc-L-Ala-&amp;gamma;-D-Glu-DAP-D-Ala" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FAD" name="FAD" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7224" name="N-acetyl-L-citrulline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1082" name="L-Ala-&amp;gamma;-D-Glu-DAP-D-Ala" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1081" name="GlcNAc-1,6-anhMurNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Amino__45__Acids__124__" name="a D-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4" name="molybdopterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GAMMA__45__GLUTAMYLCYSTEINE" name="L-&amp;gamma;-glutamylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MI__45__PENTAKISPHOSPHATE" name="D-myo-inositol (1,2,3,4,5)-pentakisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" name="2,5-diamino-6-(ribosylamino)-4-(3H)-pyrimidinone 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__209" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ARA4N__45__MODIFIED__45__KDO2__45__LIPID__45__A" name="L-Ara4N-modified KDO2-Lipid A" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP" name="GDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1086" name="5-amino-6-(5&apos;-phosphoribitylamino)uracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" name="an L-1-phosphatidylglycerol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" name="an L-1-phosphatidyl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="APS" name="adenosine 5&apos;-phosphosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__110" name="salicylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SEDOHEPTULOSE__45__7__45__P" name="D-sedoheptulose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROFOLATE" name="7,8-dihydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acceptor__124__" name="an oxidized electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ILE" name="L-isoleucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__PG" name="2-phosphoglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINAMINE" name="S-adenosyl-L-methioninamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__CYSTEINE" name="D-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__6__45__N__45__lipoyl__45__lysine__124__" name="a protein 6-N-(lipoyl)lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARG" name="L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOHEME" name="protoheme IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__CHLORO__45__24__45__DINITROBENZENE" name="1-chloro-2,4-dinitrobenzene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" name="5-phospho-ribosyl-glycineamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__200" name="chitosan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMALDEHYDE" name="formaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BISOHMYR__45__GLC" name="lipid A disaccharide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__882" name="1,6-anhMurNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEMETHYLMENAQUINONE" name="demethylmenaquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__881" name="MurNAc-6-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__SUCCINYL__45__2__45__AMINO__45__6__45__KETOPIMELATE" name="N-succinyl-2-amino-6-ketopimelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KDO2__45__LIPID__45__IVA" name="KDO2-lipid IVA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMP" name="inosine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TARTRONATE__45__S__45__ALD" name="tartronate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8978" name="ethylphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIAMINONONANOATE" name="7,8-diaminopelargonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6972" name="4-(2&apos;-carboxyphenyl)-4-oxobutyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__COA" name="acetyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__ETCETERA__45__GLUCOSAMINYLDIPHOSPHOUND" name="prenyl-P-P-GlcNAc-ManNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ" name="2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HIS" name="L-histidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOLALDEHYDE" name="glycolaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNITOL__45__1P" name="mannitol-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__335" name="(R)-3-hydroxybutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" name="4-amino-4-deoxychorismate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__D__45__GLUCOSE" name="GDP-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOAMIDE" name="lipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="COPROPORPHYRINOGEN_III" name="coproporphyrinogen III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" name="a protein L-&amp;beta;-isoaspartate &amp;alpha;-methyl ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" name="formyl-L-methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ASPARTATE" name="L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ASN" name="L-asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__8" name="ubiquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BENZOATE" name="benzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__9" name="ubiquinone-9" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" name="pyrroline 5-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Donor__45__H2__124__" name="a reduced electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CYSTATHIONINE" name="cystathionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__SUCCINYLLL__45__2__45__6__45__DIAMINOPIMELATE" name="N-succinyl-L,L-2,6-diaminopimelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1062" name="N-acyl-D-glucosamine 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GALACTONATE" name="2-dehydro-3-deoxy-D-galactonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" name="6,7-dimethyl-8-(1-D-ribityl)lumazine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL" name="pyridoxal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" name="D-myo-inositol (3)-monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8988" name="7-cyano-7-carbaguanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TREHALOSE__45__6P" name="trehalose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Diphosphates__124__" name="a ribonucleoside diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYADENOSINE" name="deoxyadenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FE__43__2" name="Fe2+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__UDP__45__N__45__acetylmuramoyl__45__Tripeptide__124__" name="a UDP-N-acetylmuramoyl-tripeptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HEPTOSYL__45__KDO2__45__LIPID__45__IVA" name="heptosyl-KDO2-lipid IVA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" name="2-octaprenyl-6-hydroxyphenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHE" name="L-phenylalanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__RIBULOSE__45__1__45__P" name="D-ribulose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEHYDROQUINATE" name="3-dehydroquinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__5P" name="D-ribose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATP" name="ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LL__45__DIAMINOPIMELATE" name="L,L-diaminopimelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBULOSE" name="D-ribulose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" name="UDP-N-acetyl-D-galactosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SARCOSINE" name="sarcosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" name="D-erythro-imidazole-glycerol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__OHMYR__45__ACETYLGLUCOSAMINE" name="UDP-3-O-(3-hydroxymyristoyl)-N-acetylglucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" name="phosphoribosylformiminoAICAR-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Long__45__Chain__45__Polyphosphate__124__" name="long chain polyphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DI__45__H__45__OROTATE" name="dihydroorotate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDRONEOPTERIN__45__P3" name="7,8-dihydroneopterin triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5170" name="(glucosyl)2(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NAD" name="NAD+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ALA__45__D__45__GLU__45__MESOA2PM" name="L-Ala-D-Glu-meso-A2pm" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__phospho__45__L__45__histidines__124__" name="a protein N-phospho-L-histidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__318" name="monodehydroascorbate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOLLATE" name="glycolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH__45__P__45__OR__45__NOP" name="NAD(P)H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__MANNOSE" name="GDP-D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCEROL__45__3P" name="sn-glycerol-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" name="dTDP-4-dehydro-6-deoxy-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUTAMATE__45__1__45__SEMIALDEHYDE" name="glutamate-1-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDPDIACYLGLYCEROL" name="a CDP-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__ATP" name="phosphoribosyl-ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__LACTATE" name="D-lactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Monophosphates__124__" name="a nucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRANS__45__D2__45__ENOYL__45__COA" name="a trans-2-enoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="URACIL" name="uracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7158" name="3-demethylubiquinone-9" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__AA__45__GLUTAMATE" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CANAVANINE" name="canavanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__PROPIONYL__45__COA" name="3-hydroxypropionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__1__45__ARSENATE" name="ribose-1-arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__3__45__HYDROXYACYL__45__COA" name="a (3S)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SUC" name="succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TYR" name="L-tyrosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARSENATE" name="arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HOMO__45__CYS" name="L-homocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__929" name="heptosyl-KDO2-lipid A" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__General__45__Phos__45__Protein__45__Substrates__124__" name="a phosphoprotein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__KETO__45__4__45__DEOXY__45__D__45__GLUCARATE" name="5-keto-4-deoxy-D-glucarate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__249" name="a sulfur donor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THREO__45__DS__45__ISO__45__CITRATE" name="D-isocitrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" name="3-deoxy-D-arabino-heptulosonate-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE" name="N-acetyl-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LYS" name="L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENYLOSUCC" name="adenylo-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DGMP" name="dGMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8180" name="DNA with lesion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1301" name="tetrahydropteroyltri-L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1302" name="5-methyltetrahydropteroyltri-L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__AP__45__Site__45__Created__124__" name="an AP(apurinic or apyrimidinic) site created by glycosylic bond cleavage" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__343" name="3-deoxy-D-glycero-2,5-hexodiulosonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUMP" name="dUMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__Histidines__124__" name="a protein histidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALO__45__SUCCINATE" name="oxalosuccinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NAD__45__P__45__OR__45__NOP" name="NAD(P)+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" name="4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1105" name="1-amino-1-deoxy-scyllo-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOPORPHYRIN_IX" name="protoporphyrin IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="E__45__4__45__HYDROXY__45__3__45__METHYLBUT__45__2__45__EN__45__1__45__YL__45__DIPH" name="(E)-4-hydroxy-3-methylbut 2-en-1-yl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" name="an unsulfurated sulfur acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7066" name="&amp;beta;-methyl-D-malate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" name="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__930" name="heptosyl2-KDO2-lipid A" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINOMALONATE__45__SEMIALDEHYDE" name="2-aminomalonate-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CITRULLINE" name="citrulline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="T__45__POLY__45__C__45__UNDECAPRENYL__45__DIPHOSPHATE" name="di-trans,poly-cis-undecaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aromatic__45__Amino__45__Acids__124__" name="an aromatic amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KDO__45__8P" name="3-deoxy-D-manno-octulosonate 8-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UNDECAPRENYL__45__DIPHOSPHATE" name="di-trans,poly-cis-undecaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALLO__45__THR" name="allothreonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__DEHYDROPANTOATE" name="2-dehydropantoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XYLITOL" name="xylitol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="deaminated__32__donor" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UROPORPHYRINOGEN__45__III" name="uroporphyrinogen-III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYLSPERMIDINE" name="an N-acetylspermidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__235" name="3-phosphonopyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C4" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl- D-alanyl-D-alanine-diphosphoundecaprenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C3" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OH__45__MYRISTOYL" name="UDP-2,3-bis(3-hydroxymyristoyl)glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C6" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C5" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROPIONYL__45__P" name="propionyl-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INDOLE" name="indole" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCERATE" name="D-glycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__377" name="2-dehydro-D-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HSCN" name="thiocyanate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1119" name="N-acylneuraminate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3OH__45__4P__45__OH__45__ALPHA__45__KETOBUTYRATE" name="2-oxo-3-hydroxy-4-phosphobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acyl__45__Phosphates__124__" name="an acyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__Hydroxy__45__carboxylates__124__" name="a 2-hydroxy carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XANTHINE" name="xanthine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CELLULOSE" name="cellulose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHYLENE__45__THF" name="5,10-methylene-THF" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CIS__45__TRANS__45__POLYISOPRENYL__45__PP" name="a cis,trans-polyisoprenyln-PP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ALPHA__45__ACETYLORNITHINE" name="N-acetyl-L-ornithine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C1" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate- D-alanyl-D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__DEHYDROGLUCONATE" name="5-ketogluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANOSINE__45__5DP__45__3DP" name="guanosine 5&apos;-diphosphate,3&apos;-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" name="phosphoribulosylformimino-AICAR-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__GLUTAMYL__45__P" name="N-acetylglutamyl-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__1P" name="ribose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__223" name="UDP-L-iduronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH" name="NADH" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__365" name="2-keto-myo-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CYS" name="L-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AICAR" name="aminoimidazole carboxamide ribonucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BISOHMYR__45__GLUCOSAMINYL__45__1P" name="2,3-bis(3-hydroxymyristoyl)-&amp;beta;-D-glucosaminyl 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" name="1-(o-carboxyphenylamino)-1&apos;-deoxyribulose-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRANS__45__POLYISOPRENYL__45__PP" name="a trans-polyisoprenyln-PP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSINE" name="adenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Carboxylic__45__esters__124__" name="a carboxylic ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="A__45__GLYCEROL__45__ESTER" name="a glycerol ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADP" name="NADP+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Amineated__45__Amine__45__Donors__124__" name="an amineated amine donor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXY__45__ACETONE__45__PHOSPHATE" name="dihydroxy-acetone phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Triphosphates__124__" name="a nucleoside triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYDROXYMETHYLBILANE" name="hydroxymethylbilane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC" name="&amp;beta;-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OCTAPRENYL__45__METHYL__45__OH__45__METHOXY__45__BENZQ" name="3-demethylubiquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="T__45__POLY__45__C__45__DECAPRENYL__45__DIPHOSPHATE" name="di-trans,poly-cis-decaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__THF__45__GLU__45__N" name="an N10-formyl-tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Carboxylates__124__" name="a carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__191" name="&amp;alpha;-D-galactosyl-diphosphoundecaprenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__hydroxyacyl__45__glutathiones__124__" name="S-(2-hydroxyacyl)glutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HISTIDINAL" name="histidinal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__479" name="2-oxo-4-methylthiobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__SULFINYL__45__PYRUVATE" name="3-sulfinyl-pyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLCNAC__45__PP__45__LIPID" name="undecaprenyl-N-acetyl-&amp;alpha;-D-glucosaminyl-pyrophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LONG__45__CHAIN__45__KETONE" name="a ketone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__292" name="2-trans-Hexadecenal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__67" name="2-phosphoglycolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__OHMYR__45__GLUCOSAMINE" name="UDP-3-O-(3-hydroxymyristoyl)glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HOMO__45__SER" name="homoserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__678" name="selenide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="QUINOLINATE" name="quinolinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__582" name="molybdopterin guanine dinucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__PHOSPHATIDATE" name="an L-phosphatidate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Quinones__124__" name="a quinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__296" name="dihydrolipoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9327" name="vanillylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" name="2-phospho-4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBULOSE__45__5P" name="D-ribulose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SUCCINATE__45__SEMIALDEHYDE__45__THIAMINE__45__PPI" name="succinate-semialdehyde-thiamine PPi" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ETHYL__45__2__45__METHYLACETOACETATE" name="ethyl-2-methylacetoacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOIC__45__ACID" name="lipoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__S__45__Substituted__45__Glutathione__124__" name="a glutathione-toxin conjugate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__694" name="cob(I)yrinate a,c-diamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYGUANOSINE" name="deoxyguanosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="VAL" name="L-valine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXYPENTANEDIONE" name="4,5-dihydroxy-2,3-pentanedione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aliphatic__45__N__45__Acetyl__45__Diamines__124__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__SERINE" name="an L-1-phosphatidylserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__689" name="cob(II)yrinate a,c-diamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYLSERINE" name="O-acetyl-L-serine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PUTRESCINE" name="putrescine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__AMINO__45__4__45__DEOXY__45__L__45__ARABINOSE" name="4-amino-4-deoxy-L-arabinose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__PANTOATE" name="L-pantoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ASPARTATE__45__SEMIALDEHYDE" name="L-aspartate-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP" name="UDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HCO3" name="HCO3-" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__Oxo__45__Acids__124__" name="a 2-oxo acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DE__45__O__45__GLUCONATE" name="2-deoxygluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ALLO__45__THREONINE" name="L-allo-threonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PORPHOBILINOGEN" name="porphobilinogen" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TDP" name="dTDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" name="2-dehydro-3-deoxy-D-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Purine__45__Bases__124__" name="a purine base" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="O__45__UREIDOHOMOSERINE" name="O-ureidohomoserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIOH__45__ISOVALERATE" name="2,3-dihydroxy-isovalerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1028" name="2-cis,6-trans,10-trans-geranylgeranyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__DEHYDRO__45__SHIKIMATE" name="3-dehydro-shikimate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHO__45__ENOL__45__PYRUVATE" name="phosphoenolpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OROTIDINE__45__5__45__PHOSPHATE" name="orotidine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DELTA3__45__ISOPENTENYL__45__PP" name="isopentenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NICOTINAMIDE_RIBOSE" name="nicotinamide riboside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRUCTOSE__45__16__45__DIPHOSPHATE" name="fructose-1,6-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHENYL__45__PYRUVATE" name="phenylpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYL__45__HOMO__45__CYS" name="S-adenosyl-L-homocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ARGININO__45__SUCCINATE" name="L-arginino-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNOSE__45__1P" name="&amp;alpha;-D-mannose 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MET" name="L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROLIPOAMIDE" name="dihydrolipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6741" name="D-myo-inositol (1,2,3,5,6) pentakisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__469" name="N-acetyl-L-glutamate 5-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THIAMINE__45__P" name="thiamine-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDRO__45__DIOH__45__BENZOATE" name="2,3-dihydro-2,3-dihydroxybenzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TDP__45__FUC4NAC" name="dTDP-4-acetamido-4,6-dideoxy-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Reduced__45__Quinones__124__" name="a hydroquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GERANYL__45__PP" name="geranyl-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEPHOSPHO__45__COA" name="dephospho-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PANTOTHENATE" name="pantothenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXYNAPHTHOATE" name="1,4-dihydroxy-2-naphthoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALACETIC_ACID" name="oxaloacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__HYDROXYMETHYLGLUTATHIONE" name="S-hydroxymethylglutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GERANYLGERANYL__45__PP" name="all-trans-geranyl-geranyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MI__45__HEXAKISPHOSPHATE" name="phytate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Beta__45__Lactams__124__" name="a &amp;beta;-lactam" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACYL__45__SN__45__GLYCEROL__45__3P" name="a 2-lysophosphatidate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__470" name="L-2,4-diaminobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__3__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" name="a nucleoside 3&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Phosphoserines__124__" name="L(or D)-O-phosphoserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROT__45__CYS" name="a protein L-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACET" name="acetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N2__45__SUCCINYLGLUTAMATE" name="N2-succinylglutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OROTATE" name="orotate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__METHYL__45__THF" name="5-methyl-THF" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC__45__6__45__P" name="&amp;beta;-D-glucose-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5161" name="(mannosyl)2-(N-acetylglucosaminyl)2-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HS" name="hydrogen sulfide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5162" name="(mannosyl)3-(N-acetylglucosaminyl)2-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUCOSAMINE__45__1P" name="D-glucosamine 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__D__45__MANNOSYLCHITOBIO" name="mannosyl-(N-acetylglucosaminyl)2-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__OXOBUTANOATE" name="2-oxobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5168" name="(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXINE__45__5P" name="pyridoxine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C55__45__PP__45__GLCNAC__45__MANNACA" name="undecaprenyl N-acetyl-glucosaminyl-N-acetyl-mannosaminuronate pyrophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5169" name="glucosyl-(mannosyl)9-(N-acetylglucosaminyl)2-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DGDP" name="dGDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBAMOYL__45__P" name="carbamoyl-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HX" name="HX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUDP" name="dUDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5165" name="(mannosyl)6-(N-acetylglucosaminyl)2-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ERYTHROSE__45__4P" name="D-erythrose-4-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5166" name="(mannosyl)7-(N-acetylglucosaminyl)2-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CROTONYL__45__COA" name="crotonyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__General__45__Protein__45__Substrates__124__" name="a protein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5167" name="(mannosyl)8-(N-acetylglucosaminyl)2-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GLUCARATE" name="D-glucarate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETO__45__ISOVALERATE" name="2-keto-isovalerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__SELENOCYSTEINE" name="L-selenocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="O__45__SUCCINYL__45__L__45__HOMOSERINE" name="O-succinyl-L-homoserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" name="a protein-N&amp;pi;-phospho-L-histidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DCDP" name="dCDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__548" name="S-formylglutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GAP" name="D-glyceraldehyde-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRUCTOSE__45__6P" name="fructose-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXINE" name="pyridoxine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__4__45__hydroxybenzoate__124__" name="4-hydroxybenzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__ACETO__45__LACTATE" name="2-acetolactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="REDUCED__45__MENAQUINONE" name="menaquinol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__37" name="5-dehydro-4-deoxy-D-glucuronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" name="all-trans-heptaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__GLU" name="N-acetyl-L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__31" name="(R)-citramalate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" name="N-acetyl-glucosamine-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDRO__45__NEO__45__PTERIN" name="7,8-dihydro-D-neopterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__3__45__DIHYDRODIPICOLINATE" name="L-2,3-dihydrodipicolinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DADP" name="dADP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__FUCULOSE" name="L-fuculose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="an__32__amine__32__donor" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ARABINOSE" name="L-arabinose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SPERMIDINE" name="spermidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" name="4-carboxyaminoimidazole ribonucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOPORPHYRINOGEN" name="protoporphyrinogen IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__6__45__N__45__octanoyl__45__lysine__124__" name="a protein 6-N-(octanoyl)lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__171" name="dolichyl &amp;beta;-D-mannosyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__THIOURIDINE" name="2-thiouridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Orthophosphoric__45__Monoesters__124__" name="a phosphate monoester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" name="(2S)-2-amino-3-oxo-4-phosphonooxybutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__558" name="pimeloyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__P" name="acetylphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PANTOYL__45__LACTONE" name="pantoyl lactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__564" name="S-ribosyl-L-homocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__METHYLMALEATE" name="citraconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" name="L-erythro-4-hydroxy-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__DNA__45__Combined__45__With__45__Exogenous__45__DNA__124__" name="DNA combined with exogenous DNA to form a recombinational junction" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__GLUCURONATE" name="UDP-D-glucuronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PREPHENATE" name="prephenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCERALD" name="glyceraldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NICOTINAMIDE_NUCLEOTIDE" name="nicotinamide mononucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__ACETYLMURAMOYL__45__ALA" name="UDP-N-acetylmuramoyl-L-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__RIBULOSE" name="L-ribulose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Stabilized__45__RecA__45__Filament__45__DNA__45__Complex__124__" name="a stabilized RecA filament-DNA complex" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ARABITOL" name="L-arabitol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="URIDINE" name="uridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__425" name="hippurate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__166" name="dolichyl &amp;beta;-D-glucosyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HCN" name="hydrogen cyanide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRUVATE" name="pyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SORBITOL__45__6__45__P" name="D-sorbitol-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HCL" name="HCl" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MAL" name="malate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYURIDINE" name="deoxyuridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7100" name="2-isopropyl-3-oxosuccinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HEPTA__45__ACYLATED__45__LIPID__45__A" name="hepta-acylated KDO2-lipid A" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LEU" name="L-leucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GLUTAMATE__45__5__45__P" name="L-glutamate-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ORNITHINE" name="L-ornithine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GLUCOSAMINE__45__6__45__P" name="D-glucosamine-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UNDECAPRENYL__45__P" name="undecaprenyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" name="D-galactosamine-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" name="L-glutamate &amp;gamma;-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXIDIZED__45__GLUTATHIONE" name="glutathione disulfide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__822" name="N2-succinyl-L-glutamate 5-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="VITAMIN_K_2" name="menaquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__MANNACA" name="UDP-N-acetyl-&amp;beta;-D-mannosaminouronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Purine__45__Ribonucleosides__124__" name="a purine ribonucleoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__624" name="N-acylneuraminate 9-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ENZYME__45__S__45__SULFANYLCYSTEINE" name="a protein-S-sulfanylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SHIKIMATE" name="shikimate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Lipopolysaccharides__124__" name="a lipopolysaccharide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aromatic__45__Oxoacids__124__" name="an aromatic oxo-acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANOSINE_DIPHOSPHATE_FUCOSE" name="GDP-L-fucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SIROHEME" name="siroheme" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__UDP__45__NAcMur__45__Peptides__124__" name="a UDP-N-acetylmuramoyl-pentapeptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CMP__45__KDO" name="CMP-3-deoxy-D-manno-octulosonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE" name="2-C-methyl-D-erythritol-4-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__AMP" name="phosphoribosyl-AMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" name="phosphoribosyl-formamido-carboxamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_7__45__CYANO__45__7__45__DEAZAGUANINE" name="7-cyano-7-deazaguanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" name="5&apos;-phosphoribosyl-N-formylglycineamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XANTHOSINE" name="xanthosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TMP" name="dTMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="G3P" name="3-phosphoglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRU" name="D-fructose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P__45__AMINO__45__BENZOATE" name="p-aminobenzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" name="R-4&apos;-phosphopantothenoyl-L-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBAMYUL__45__L__45__ASPARTATE" name="N-carbamoyl-L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__TP" name="guanosine 3&apos;-diphosphate 5&apos;-triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2961" name="6-phospho-D-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="VANILLIN" name="vanillin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ETHYL__45__2R__45__METHYL__45__3S__45__HYDROXYBUTANOATE" name="ethyl-(2R)-methyl-(3S)-hydroxybutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CANALINE" name="L-canaline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" name="5-phospho-&amp;beta;-D-ribosyl-amine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Deoxy__45__Ribonucleoside__45__Diphosphates__124__" name="a 2&apos;-deoxyribonucleoside diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleotides__124__" name="a nucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Deamineated__45__Amine__45__Donors__124__" name="a deamineated amine donor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5727" name="5,10-methenyl-tetrahydropteroyl-[&amp;gamma;-Glu](n)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXYACYL__45__COA" name="a 3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Damaged__45__DNA__124__" name="a damaged DNA (purine or pyrimidine)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINO__45__ETCETERA__45__TRIPHOSPHATE" name="2-amino-4-oxo-6-(erythro-1&apos;,2&apos;,3&apos;-trihydroxyprolyl)-7,8-dihydroxypteridine triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__650" name="3-hydroxybutyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9454" name="di-trans,poly-cis-octaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__Acylglycero__45__Phosphocholines__124__" name="a 1-lyso-2-acyl-sn-glycero-3-phosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Galactose__124__" name="D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9455" name="di-trans,poly-cis-heptaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Fatty__45__Acyl__45__CoA__124__" name="a fatty acyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9456" name="di-trans,poly-cis-hexaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9457" name="di-trans,poly-cis-pentaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9451" name="isopropylmaleate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OCTAPRENYL__45__DIPHOSPHATE" name="all-trans-octaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROPTERIN__45__CH2OH__45__PP" name="(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9453" name="di-trans,poly-cis-nonaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KDO2__45__LIPID__45__A" name="KDO2-lipid A" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GLT" name="D-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LACTOSE" name="lactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9452" name="di-trans,poly-cis-decaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDP" name="CDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KDO__45__LIPID__45__IVA" name="(KDO)-lipid IVA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" name="UDP-N-acetyl-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KDO" name="3-deoxy-D-manno-octulosonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LACTALD" name="L-lactaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__N__45__ACETYLMURAMATE" name="UDP-N-acetylmuramate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" name="geranylfarnesyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__DEOXY__45__D__45__GLUCOSE" name="2-deoxy-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__KETOBUTYRATE" name="acetoacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GTP" name="GTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CANAVANINOSUCCINATE" name="canavaninosuccinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INDOLE__45__3__45__GLYCEROL__45__P" name="indole-3-glycerol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__Dithiols__124__" name="a protein dithiol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" name="3-isopropylmalate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DI__45__H__45__URACIL" name="dihydrouracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SULFATE" name="sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Resolution__45__of__45__Recombinational__45__Junction__124__" name="resolution of recombinational junction formation of two intact strands" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETO__45__GLUTARAMATE" name="2-keto-glutaramate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Lysine__45__or__45__DAP__124__" name="an L-lysine or meso-2,6-diaminoheptanedioate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" name="UDP-GlcNAc-enolpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__841" name="N-acyl-D-mannosamine 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__D__45__GLUCOSAMINYLDIPHOSPHO__45__UNDECAPRE" name="prenyl-P-P-GlcNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__ALPHABETA__45__D__45__HEPTOSE__45__7__45__PHOSPHATE" name="D-&amp;alpha;,&amp;beta;-D-heptose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FUM" name="fumarate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__RIBULOSE__45__15__45__P2" name="D-ribulose-1,5-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNOSE__45__6P" name="D-mannose-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SUC__45__COA" name="succinyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CADAVERINE" name="cadaverine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CYTIDINE" name="cytidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__ALANINE" name="D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__3__45__HYDROXYACYL__45__COA" name="an (R)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4211" name="dimethylallyl-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THR" name="L-threonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" name="2-keto-3-deoxy-6-phospho-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THF" name="tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__GLUCOSE" name="UDP-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LACTOSE__45__6P" name="lactose 6&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HISTIDINOL" name="histidinol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPID__45__IV__45__A" name="lipid IVA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__RIBULOSE__45__5__45__P" name="L-ribulose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__METHYLTHIOADENOSINE" name="S-methyl-5&apos;-thioadenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RHAMNOSE" name="L-rhamnose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P__45__HYDROXY__45__PHENYLPYRUVATE" name="4-hydroxyphenylpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__P__45__SERINE" name="3-phospho-serine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Alkyl__45__Hydro__45__Peroxides__124__" name="an alkylhydroperoxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROSIROHYDROCHLORIN" name="precorrin-2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DAMP" name="dAMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINOL__45__8" name="ubiquinol-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__BETA__45__D__45__HEPTOSE__45__1__45__P" name="D-&amp;beta;-D-heptose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__ETCETERA__45__LIPOPOLYSACCHARIDE" name="N-acetyl-D-glucosaminyl-lipopolysaccharide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CAMP" name="cyclic-AMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INOSINE" name="inosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE" name="D-ribose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" name="GDP-4-dehydro-6-deoxy-D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3686" name="2-aminobutyrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FARNESYL__45__PP" name="(E,E)-farnesyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYOX" name="glyoxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHORISMATE" name="chorismate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__BETA__45__ASPARTYL__45__P" name="L-aspartyl-4-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MYO__45__INOSITOL" name="myo-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADP" name="ADP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__763" name="arsenite" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__Disulfides__124__" name="a protein disulfide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UMP" name="UMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEAMIDO__45__NAD" name="deamido-NAD" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" name="2-methyl-3-hydroxybutyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROPIONYL__45__COA" name="propionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DCMP" name="dCMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYPOXANTHINE" name="hypoxanthine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_10__45__FORMYL__45__THF" name="10-formyl-tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SHIKIMATE__45__5P" name="shikimate-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="O__45__PHOSPHO__45__L__45__HOMOSERINE" name="O-phospho-L-homoserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THZ" name="4-methyl-5-(&amp;beta;-hydroxyethyl)thiazole" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__P__45__PANTOTHENATE" name="D-4&apos;-phosphopantothenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" name="5-enolpyruvyl-shikimate-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" name="5-aminoimidazole ribonucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SUCROSE" name="sucrose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADP__45__D__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" name="ADP-D-glycero-D-manno-heptose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PAPS" name="phosphoadenosine-5&apos;-phosphosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__SULFINOALANINE" name="3-sulfinoalanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TAGATOSE__45__6__45__PHOSPHATE" name="tagatose-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SER" name="L-serine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALONYL__45__COA" name="malonyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHYL__45__GLYOXAL" name="methylglyoxal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleosides__124__" name="a ribonucleoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9038" name="precorrin-1" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADP__45__SUGARS" name="an ADP-sugar" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__UREIDO__45__PROPIONATE" name="3-ureidopropionate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__602" name="5-amino-6-(5&apos;-phosphoribosylamino)uracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__AMINO__45__PROPAN__45__2__45__ONE__45__3__45__PHOSPHATE" name="1-amino-propan-2-one-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TAGATOSE__45__1__45__6__45__DIPHOSPHATE" name="tagatose-1,6-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1112" name="&amp;beta;-L-rhamnose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" name="D-glucono-&amp;delta;-lactone-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INDOLE_PYRUVATE" name="indole-3-pyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THIAMINE__45__PYROPHOSPHATE" name="thiamine diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHACRYLYL__45__COA" name="methylacrylyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CIS__45__ACONITATE" name="cis-aconitate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__L__45__BETA__45__ISOASPARTATES" name="a protein L-&amp;beta;-isoaspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_7__45__8__45__DIHYDROPTEROATE" name="7,8-dihydropteroate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TREHALOSE" name="trehalose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANINE" name="guanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Unstable__45__RecA__45__Filament__45__DNA__45__Complex__124__" name="an unstable RecA filament-DNA complex" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" name="5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AGMATHINE" name="agmatine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TIGLYL__45__COA" name="tiglyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NIACINE" name="nicotinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S8" name="S0" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RX" name="RX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Phospholipids__124__" name="a phospholipid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RHAMNULOSE" name="L-rhamnulose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CIT" name="citrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETO__45__3__45__METHYL__45__VALERATE" name="2-keto-3-methyl-valerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUTATHIONE" name="glutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSE__45__1P" name="&amp;alpha;-D-galactose 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Sugar__124__" name="a sugar" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__MANNAC" name="UDP-N-acetyl-D-mannosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" name="ADP-L-glycero-D-manno-heptose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" name="5&apos;-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NICOTINATE_NUCLEOTIDE" name="nicotinate nucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MESO__45__DIAMINOPIMELATE" name="meso-diaminopimelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__ARABINOSE" name="D-arabinose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXY__45__BUTANONE__45__P" name="3,4-dihydroxy-2-butanone-4-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" name="6-pyruvoyl tetrahydropterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8550" name="a substituted &amp;beta;-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S2O3" name="thiosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSINE_DIPHOSPHATE_RIBOSE" name="ADP-ribose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TTP" name="dTTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Deoxynucleotides__124__" name="a deoxynucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXY__45__RIBOSE__45__5P" name="deoxyribose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__1__45__Acylglycero__45__Phosphocholines__124__" name="a 1-acyl-2-lyso-glycerophosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LINOLENIC_ACID" name="linolenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__GLC__45__6__45__P" name="&amp;alpha;-D-glucose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8653" name="betanidin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__ALA__45__D__45__ALA" name="D-alanyl-D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" name="tetrahydrodipicolinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OH__45__PYR" name="hydroxypyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SIROHYDROCHLORIN" name="sirohydrochlorin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__MANNONATE" name="D-mannonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__D__45__MANNOSYL__45__3__45__PHOSPHOGLYCERATE" name="mannosyl-3-phosphoglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8259" name="nicotinate riboside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__LACTOYL__45__GLUTATHIONE" name="S-lactoyl-glutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2K__45__4CH3__45__PENTANOATE" name="2-ketoisocaproate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__PHOSPHONOOXY__45__THREONINE" name="4-(phosphonooxy)-threonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETOGLUTARATE" name="2-ketoglutarate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Triphosphates__124__" name="a ribonucleoside triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PALMITYL__45__COA" name="palmitoyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__1__45__4__45__beta__45__D__45__Glucan__124__" name="a 1,4-&amp;beta;-D-glucan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__24__45__DINITROPHENYLGLUTATHIONE" name="2,4-dinitrophenyl-S-glutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XYLULOSE__45__5__45__PHOSPHATE" name="D-xylulose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" name="5-phosphoribosyl-N-formylglycineamidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCEROL" name="glycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__XYLULOSE" name="D-xylulose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETALD" name="acetaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE" name="2-C-methyl-D-erythritol-2,4-cyclodiphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__tyrosine__45__phosphates__124__" name="a protein-L-tyrosine phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FMNH2" name="FMNH2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GMP" name="GMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FMN" name="FMN" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8534" name="DNA without lesion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIACYLGLYCEROL" name="a 1,2-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8537" name="tRNA pseudouridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__AMINO__45__LEVULINATE" name="5-amino-levulinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE" name="3-octaprenyl-4-hydroxybenzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRP" name="L-tryptophan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CH33ADO" name="5&apos;-deoxyadenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SUCC__45__S__45__ALD" name="succinate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THYMINE" name="thymine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8533" name="AP site on DNA created by glycosylase in repair process" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8532" name="AP site removed from DNA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOFLAVIN" name="riboflavin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8538" name="tRNA uridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHIONYL__45__PEPTIDE" name="methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Serines__124__" name="(L) or (D)-serine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GALACTONATE" name="D-galactonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ANTHRANILATE" name="anthranilate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC__45__1__45__P" name="&amp;alpha;-D-glucose 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__HISTIDINOL__45__P" name="L-histidinol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XANTHOSINE__45__5__45__PHOSPHATE" name="xanthosine-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Glycerophosphodiesters__124__" name="a glycerophosphodiester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" name="6-hydroxymethyl-7,8-dihydropterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ISOCHORISMATE" name="isochorismate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLY" name="glycine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANOSINE" name="guanosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CMP" name="CMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUCONATE" name="D-gluconoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYL__45__P4" name="5&apos;,5&apos;&apos;&apos;-diadenosine tetraphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLN" name="L-glutamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__Tyrosines__124__" name="a protein L-tyrosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FUCULOSE__45__1P" name="L-fuculose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__KETO__45__2__45__METHYLVALERATE" name="2,3-dihydroxy-3-methylvalerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__O__45__ALPHA__45__MANNOSYL__45__D__45__GLYCERATE" name="mannosylglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PALMITALDEHYDE" name="palmitaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PRPP" name="5-phosphoribosyl 1-pyrophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLT" name="L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ASCORBATE" name="L-ascorbate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C55__45__PP__45__GLCNAC__45__MANNACA__45__FUC4NAC" name="undecaprenyl N-acetyl-glucosaminyl-N-acetyl-mannosaminuronate-4-acetamido-4,6-dideoxy-D-galactose pyrophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARABINOSE__45__5P" name="D-arabinose 5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__OCTAPRENYL__45__6__45__METHOXYPHENOL" name="2-octaprenyl-6-methoxyphenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_8__45__AMINO__45__7__45__OXONONANOATE" name="7-keto-8-aminopelargonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_25__45__DIDEHYDRO__45__D__45__GLUCONATE" name="2,5-didehydro-D-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ALPHA__45__ALANINE" name="L-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__OCTAPRENYLPHENOL" name="2-octaprenylphenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMP" name="AMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ETOH" name="ethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UTP" name="UTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CATECHOL" name="catechol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THYMIDINE" name="thymidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMATE" name="formate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8890" name="betanidin quinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXY__45__RIBOSE__45__1P" name="deoxyribose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" name="3-hydroxy-isobutyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PRO" name="L-proline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__FUCOSE" name="L-fucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P3I" name="PPPi" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DTDP__45__D__45__GLUCOSE" name="dTDP-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RHAMNULOSE__45__1P" name="L-rhamnulose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYCYTIDINE" name="deoxycytidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRU1P" name="fructose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUTP" name="dUTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DE__45__O__45__K__45__GLUCONATE" name="3-dehydro-2-deoxy-D-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FADH2" name="FADH2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Sulfurated__45__Sulfur__45__Acceptors__124__" name="a sulfurated sulfur donor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" name="2-aceto-2-hydroxy-butyrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" name="N-acetyl-D-galactosamine-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PANTETHEINE__45__P" name="pantetheine 4&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PSEUDOURIDINE__45__5__45__P" name="pseudouridine 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" name="pyrroline-hydroxy-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRUCTURONATE" name="fructuronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DETHIOBIOTIN" name="dethiobiotin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DPG" name="1,3-diphosphateglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYXYLULOSE__45__5P" name="1-deoxy-D-xylulose 5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BIOTIN" name="biotin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CO__45__A" name="coenzyme A" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARDIOLIPIN" name="cardiolipin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Sugar__45__Phosphate__124__" name="a sugar phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CTP" name="CTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMINOASPARTATE" name="iminoaspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACRYLYL__45__COA" name="acrylyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHATIDYLCHOLINE" name="a phosphatidylcholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE" name="S-adenosyl-4-methylthio-2-oxobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Peptidoglycans__124__" name="a peptidoglycan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" name="2-isopropylmalate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THZ__45__P" name="4-methyl-5-(&amp;beta;-hydroxyethyl)thiazole phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DGTP" name="dGTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5662" name="9-mercaptodethiobiotin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_14__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYLN1" name="chitin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENINE" name="adenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__GALACTOSE" name="UDP-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DOLICHOLP" name="dolichyl-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ERYTHRONATE__45__4P" name="erythronate-4-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7695" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__P__45__HYDROXYPYRUVATE" name="3-phospho-hydroxypyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="QUEUINE" name="queuine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMIDAZOLE__45__ACETOL__45__P" name="imidazole acetol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Cis__45__2__45__enoyl__45__CoAs__124__" name="a cis-2-enoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SO3" name="sulfite" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" name="N-acetyl-D-glucosamine-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SULFUR__45__DIOXIDE" name="sulphur dioxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_7__45__AMINOMETHYL__45__7__45__DEAZAGUANINE" name="7-aminomethyl-7-deazaguanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Alcohols__124__" name="an alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__10__45__METHENYL__45__THF" name="5,10-methenyltetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Chitosan__124__" name="chitosan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UREA" name="urea" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" name="all-trans-hexaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" name="an L-1-phosphatidyl-glycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINE" name="S-adenosyl-L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__BETA__45__D__45__HEPTOSE__45__17__45__DIPHOSPHATE" name="D-&amp;beta;-D-heptose-1,7-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__DEOXY__45__D__45__GLUCOSE__45__6__45__PHOSPHATE" name="2-deoxy-D-glucose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYINOSINE" name="deoxyinosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DATP" name="dATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P__45__COUMAROYL__45__COA" name="4-coumaroyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADP__45__D__45__GLUCOSE" name="ADP-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8624" name="peptidylproline (&amp;omega; = 180)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINO__45__ETCETERA__45__DIHYDROXYPTERIDINE" name="2-amino-4-oxo-6-(1&apos;,2&apos;-dioxoprolyl)-7,8-dihydroxypteridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DCTP" name="dCTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8625" name="peptidylproline (&amp;omega; = 0)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="O__45__SUCCINYLBENZOYL__45__COA" name="O-succinylbenzoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" name="N-(5&apos;-phosphoribosyl)-anthranilate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYNUCLEOTIDESM" name="(deoxynucleotides)(m)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
</listOfSpecies>
<listOfReactions>
  <reaction id="MANNONDEHYDRAT__45__RXN" name="Mannonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1838 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative mannonate dehydratase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__MANNONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GST__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1609 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glutathione S-transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__CHLORO__45__24__45__DINITROBENZENE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="S__45__24__45__DINITROPHENYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYADENPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHEAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1128 ) or ( SG1006 ) or ( SG2131 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinol-phosphate aminotransferase HisC ) or ( aromatic amino acid aminotransferase ) or ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__274__45__RXN" name="2,5-didehydrogluconate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1982 ) or (  ) or ( SG0278 ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldo/keto reductase ) or ( 2,5-diketo-D-gluconate reductase A (fragment) ) or ( putative 2,5-diketo-D-gluconate reductase A ) or ( 2,5-diketo-D-gluconate reductase A (fragment) ) or ( putative oxidoreductase (fragment) ) or ( 2,5-diketo-D-gluconate reductase A (fragment) )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.274</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_25__45__DIDEHYDRO__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2159_argH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Argininosuccinate lyase (Arginosuccinase) (ASAL)//ARGSUCCINLYA-RXN//Argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2391_ilvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ketol-acid reductoisomerase (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase)//ACETOLACTREDUCTOISOM-RXN//ACETOOHBUTREDUCTOISOM-RXN//Ketol-acid reductoisomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERPHOSPHA__45__RXN" name="Phosphoserine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0398_serB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phosphoserines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Serines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATEMUT__45__RXN" name="Chorismate mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0579_tyrA ) or ( SG0580_pheA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional chorismate mutase/prephenate dehydrogenase//CHORISMATEMUT-RXN//PREPHENATEDEHYDROG-RXN ) or ( bifunctional chorismate mutase/prephenate dehydratase//CHORISMATEMUT-RXN//PREPHENATEDEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4OHBENZOATE__45__OCTAPRENYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2143_ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase) )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATESYNTH__45__RXN" name="dihydrofolate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1616 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional folylpolyglutamate synthase/ dihydrofolate synthase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7744" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0435 ) or ( SG0434_leuD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopropylmalate isomerase large subunit ) or ( isopropylmalate isomerase small subunit//3-ISOPROPYLMALISOM-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__METHYLMALEATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7066" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16ALDOLASE__45__RXN" name="Fructose-bisphosphate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2014 ) or ( SG1113 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-bisphosphate aldolase ) or ( UTP-glucose-1-phosphate uridylyltransferase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7607" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0528_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Multifunctional protein surE [Includes: 5&apos;/3&apos;-nucleotidase (Nucleoside monophosphate phosphohydrolase); Exopolyphosphatase ]//3-NUCLEOTID-RXN//5&apos;-NUCLEOTID-RXN//3&apos;-nucleotidase//Exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7609" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0528_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Multifunctional protein surE [Includes: 5&apos;/3&apos;-nucleotidase (Nucleoside monophosphate phosphohydrolase); Exopolyphosphatase ]//3-NUCLEOTID-RXN//5&apos;-NUCLEOTID-RXN//3&apos;-nucleotidase//Exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENETHFDEHYDROG__45__NADP__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0706_folD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofolate cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: reductive acetyl coenzyme A pathway</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRAISOM__45__RXN" name="Phosphoribosylanthranilate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1399 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.24</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__NH3__45__RXN" name="GMP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1748_guaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional GMP synthase/glutamine amidotransferase protein//GMP-SYN-GLUT-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1842" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1577 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( palmitoyl transferase for Lipid A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phospholipids__124__" stoichiometry="1"/>
      <speciesReference species="KDO2__45__LIPID__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__45__GLYCEROL__45__ESTER" stoichiometry="1"/>
      <speciesReference species="HEPTA__45__ACYLATED__45__LIPID__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__56__45__RXN" name="Lipopolysaccharide N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0239 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative heptosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.56</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Lipopolysaccharides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__ETCETERA__45__LIPOPOLYSACCHARIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSLIG__45__RXN" name="Phosphopantothenate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2209 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPHOSPHOR__45__RXN" name="Guanosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.15</html:p>
<html:p>SIDE: RIBOSE__45__1P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__PHYT__45__RXN" name="6-phytase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG1350 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit ; periplasmic-binding component of ABC superfamily (fragment) ) or ( protease 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MI__45__PENTAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTRACE__45__RXN" name="Glutamate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2153 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate racemase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMACTRAN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1899 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine N1-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLSPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__DEHYDRATASE__45__RXN" name="3-dehydroquinate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0154 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-dehydroquinate dehydratase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM3780_argG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate synthetase//ARGSUCCINSYN-RXN )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RHAMNULOKIN__45__RXN" name="Rhamnulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( rhamnulokinase (fragment) )</html:p>
<html:p>SUBSYSTEM: rhamnose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RHAMNULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RHAMNULOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__761" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1241 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__13__45__RXN" name="L-arabinitol 2-dehydrogenase (ribulose forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0404_thrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional aspartokinase I/homeserine dehydrogenase I//ASPARTATEKIN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.13</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARABITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__RIBULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTOX__45__RXN" name="Dihydroorotate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1018 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotate dehydrogenase 2 )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATE__45__SYNTHASE__45__RXN" name="Chorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1627_aroC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase)//CHORISMATE-SYNTHASE-RXN//Chorismate synthase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.5</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HIPPURATE__45__HYDROLASE__45__RXN" name="Hippurate hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1744 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.32</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__425" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7615" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM3899 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Naphthoate synthase//Naphthoate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.36</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6972" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXYNAPHTHOATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__3__45__PHOSPHATE__45__DEHYDROGENASE__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2329_glpD ) or ( SG2184_gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase//GLYC3PDEHYDROG-RXN ) or ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSDECARBOX__45__RXN" name="Lysine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysine decarboxylase 2, constitutive (fragment) ) or ( lysine decarboxylase 2, constitutive (fragment) ) or ( lysine decarboxylase 2, constitutive (fragment) ) or ( lysine decarboxylase 2, constitutive (fragment) ) or ( lysine decarboxylase 2, constitutive (fragment) )</html:p>
<html:p>SUBSYSTEM: lysine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.18</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CADAVERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSE6PSYN__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1241 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.15</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FMN_TO_FMNH2_COF_RXN" name="FMN_TO_FMNH2_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMNH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTEROATESYNTH__45__RXN" name="Dihydropteroate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0372_folP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydropteroate synthase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.15</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__AMINOTRANSFERASE__45__RXN" name="Tryptophan aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1006 ) or ( SG2131 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase ) or ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VII (via indole-3-pyruvate)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.27</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2001" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0291_arnT ) or ( SG1841_arnT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-amino-4-deoxy-L-arabinose transferase ) or ( 4-amino-4-deoxy-L-arabinose transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXY__45__L__45__ARABINOSE" stoichiometry="2"/>
      <speciesReference species="KDO2__45__LIPID__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARA4N__45__MODIFIED__45__KDO2__45__LIPID__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CPM__45__KDOSYNTH__45__RXN" name="3-deoxy-manno-octulosonate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0998 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-manno-octulosonate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.38</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="KDO" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSALDOL__45__RXN" name="Transaldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG1714 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transaldolase B (fragment) ) or ( transaldolase A ) or ( transaldolase B (fragment) )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYPYPHOSPHA__45__RXN" name="CDP-diacylglycerol pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM0136_cdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diacylglycerol phosphotidylhydrolase//CDPDIGLYPYPHOSPHA-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.26</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP_TO_GDP_COF_RXN" name="GTP_TO_GDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADPSUGPPHOSPHAT__45__RXN" name="ADP-sugar diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2312_nudE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-ribose diphosphatase NudE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.21</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__SUGARS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alpha__45__D__45__aldose__45__1__45__phosphates__124__" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCSEMIALDDEHYDROG__45__RXN" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0164 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative succinate-semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPH_TO_NADP_COF_RXN" name="NADPH_TO_NADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__A1__45__RXN" name="Phospholipase A1" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2338 ) or ( SG2218 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase A ) or ( putative phospholipase A )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.32</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__77__45__RXN" name="Protein-L-isoaspartate(D-aspartate) O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0529_pcm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein-L-isoaspartate O-methyltransferase//2.1.1.77-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.77</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOASPARTATES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PABSYNMULTI__45__RXN" name="synthesis of p-aminobenzoic acid" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2302 ) or ( SG1329 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( para-aminobenzoate synthase component II ) or ( para-aminobenzoate synthase component I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CELLULOSE__45__SYNTHASE__45__UDP__45__FORMING__45__RXN" name="Cellulose synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cellulose synthase, catalytic subunit (fragment) ) or ( Cellulose synthase 1 operon protein C precursor (fragment) ) or ( cellulose synthase, catalytic subunit (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.12</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAICARSYN__45__RXN" name="Phosphoribosylaminoimidazole-succinocarboxamide synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1724 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole-succinocarboxamide synthase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCDIAMINOPIMDESUCC__45__RXN" name="Succinyl-diaminopimelate desuccinylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1718 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl-diaminopimelate desuccinylase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.18</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__SUCCINYLLL__45__2__45__6__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORPYRLY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2144_ubiC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Chorismate--pyruvate lyase (CL) (CPL)//CHORPYRLY-RXN )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: 4-hydroxybenzoate biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.40</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATPPHOSPHORIBOSYLTRANS__45__RXN" name="ATP phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1130_hisG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.17</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAMPYR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0990 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3OH__45__4P__45__OH__45__ALPHA__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP_TO_GDP__45__MANNOSE_COF_RXN" name="GDP_TO_GDP-MANNOSE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDO__45__8PSYNTH__45__RXN" name="2-dehydro-3-deoxyphosphooctonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1873_kdsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-dehydro-3-deoxyphosphooctonate aldolase (Phospho-2- dehydro-3-deoxyoctonate aldolase) (3-deoxy-D-manno-octulosonic acid 8- phosphate synthetase) (KDO-8-phosphate synthetase) (KDO 8-P synthase) (KDOPS)//KDO-8PSYNTH-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.55</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARABINOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO__45__8P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__HEXAPRENYLTRANSTRANSFERASE__45__RXN" name="trans-hexaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0362 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.30</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URPHOS__45__RXN" name="Uridine phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0107 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine phosphorylase )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM2__45__RXN" name="Cytidine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0968 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCPALDOL__45__RXN" name="L-fuculose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0183 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-fuculose phosphate aldolase )</html:p>
<html:p>SUBSYSTEM: fucose degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FUCULOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTALD" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AGMATIN__45__RXN" name="Agmatinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( agmatinase )</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine degradation III (arginine decarboxylase/agmatinase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AGMATHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__271__45__RXN" name="GDP-L-fucose synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0330 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-L-fucose-synthase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.271</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2395 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__PENTAPRENYLTRANSFERASE__45__RXN" name="Trans-pentaprenyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0362 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.33</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__COUMAROYL__45__COA_TO_CO__45__A_COF_RXN" name="P-COUMAROYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="P__45__COUMAROYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDRODIPICSYN__45__RXN" name="dihydrodipicolinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG1726 ) or ( SODGM3759 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative lyase/synthase (dapA-like); KpLE2 phage-like element (fragment) ) or ( dihydrodipicolinate synthase ) or ( putative Dihydrodipicolinate synthase (DHDPS)//Dihydrodipicolinate synthase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.52</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCOSE_TO_UDP_COF_RXN" name="UDP-GLUCOSE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREDEHYD__45__RXN" name="Threonine dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2393 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCROSE__45__PHOSPHORYLASE__45__RXN" name="Sucrose phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2323 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sucrose phosphorylase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.7</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHUROPORDEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0520 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( siroheme synthase )</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.76</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4157" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1006 ) or ( SG2131 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase ) or ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.58</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTPDECARB__45__RXN" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1414_pyrF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Orotidine 5&apos;-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase)//OROTPDECARB-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.23</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2023" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1085_trmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__THIOURIDINE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG6PDEACET__45__RXN" name="N-acetylglucosamine-6-phosphate deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0815_nagA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine-6-phosphate deacetylase )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPSYNTH__45__RXN" name="Pyruvate,water dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1429 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoenolpyruvate synthase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.2</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROT__45__RXN" name="Dihydroorotase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1051 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROG__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2329_glpD ) or ( SG2184_gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase//GLYC3PDEHYDROG-RXN ) or ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN )</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donors reaction list</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSNACMURPENTATRANS__45__RXN" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0446_mraY ) or ( SG2385 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phospho-N-acetylmuramoyl-pentapeptide-transferase (UDP- MurNAc-pentapeptide phosphotransferase)//PHOSNACMURPENTATRANS-RXN//Phospho-N-acetylmuramoyl-pentapeptide-transferase ) or ( undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: UNDECAPRENYL__45__P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
      <speciesReference species="C1" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C5" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMPCYCLOHYDROLASE__45__RXN" name="IMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0143 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazolecarboxamide formyltransferase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOKIN__45__RXN" name="Galactokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0895 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative galactokinase )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Galactose__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2602" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2206 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formamidopyrimidine-DNA glycosylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.23</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Damaged__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__AP__45__Site__45__Created__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLPHOSPHATASE__45__RXN" name="Acylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1038 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acylphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acyl__45__Phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPDECARBOX__45__RXN" name="Aspartate 1-decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0486_panD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aspartate 1-decarboxylase precursor (Aspartate alpha- decarboxylase) [Contains: Aspartate 1-decarboxylase beta chain; Aspartate 1-decarboxylase alpha chain]//ASPDECARBOX-RXN//Aspartate 1-decarboxylase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.11</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPXPRIBOSYLTRAN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0598_gpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Xanthine phosphoribosyltransferase (Xanthine-guanine phosphoribosyltransferase) (XGPRT)//XANPRIBOSYLTRAN-RXN//Xanthine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2606" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0691_recR ) or ( SG0003_recF ) or ( SG1785_recO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( recombination protein RecR ) or ( DNA replication and repair protein recF ) or ( DNA repair protein recO (Recombination protein O) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Unstable__45__RecA__45__Filament__45__DNA__45__Complex__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Stabilized__45__RecA__45__Filament__45__DNA__45__Complex__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENMETSYN__45__RXN" name="Methionine adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2019_metK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT)//S-ADENMETSYN-RXN//Methionine adenosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNP__45__RXN" name="Purine-nucleoside phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOX__45__RXN" name="Sarcosine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-methyltryptophan oxidase, FAD-binding (fragment) )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__DEHYDROPANTOATE__45__REDUCT__45__RXN" name="2-dehydropantoate 2-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0661 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-dehydropantoate 2-reductase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.169</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADOMET__45__DMK__45__METHYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SGP1_0033 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative demethylmenaquinone methyltransferase )</html:p>
<html:p>SUBSYSTEM: menaquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEMETHYLMENAQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VITAMIN_K_2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__SYN__45__RXN" name="glutathione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2022 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione synthetase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__NUCLEOTID__45__RXN" name="3&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0528_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Multifunctional protein surE [Includes: 5&apos;/3&apos;-nucleotidase (Nucleoside monophosphate phosphohydrolase); Exopolyphosphatase ]//3-NUCLEOTID-RXN//5&apos;-NUCLEOTID-RXN//3&apos;-nucleotidase//Exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1441" name="ADP-ribose pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0267 ) or ( SG2312_nudE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ADP-ribose pyrophosphatase ) or ( ADP-ribose diphosphatase NudE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE_DIPHOSPHATE_RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__II__45__RXN" name="GTP cyclohydrolase II" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1410_ribA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP cyclohydrolase II )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.25</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEHYDROG__45__RXN" name="Homoserine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG0404_thrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused aspartokinase II ; homoserine dehydrogenase II (fragment) ) or ( bifunctional aspartokinase I/homeserine dehydrogenase I//ASPARTATEKIN-RXN )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1243_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1243_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALA__45__GLU__45__LIG__45__RXN" name="UDP-N-acetylmuramoylalanine--D-glutamate ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0447_murD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanine--D-glutamate ligase (UDP-N- acetylmuramoyl-L-alanyl-D-glutamate synthetase) (D-glutamic acid- adding enzyme)//UDP-NACMURALA-GLU-LIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__ACETYLMURAMOYL__45__ALA" stoichiometry="1"/>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATESYN__45__RXN" name="Thymidylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1977_thyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate synthase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.45</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: DIHYDROFOLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLULOKIN__45__RXN" name="Xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0611 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylulose kinase )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCULOKIN__45__RXN" name="L-fuculokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0180 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-fuculokinase )</html:p>
<html:p>SUBSYSTEM: fucose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.51</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__FUCULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUCULOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1041" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0511_mazG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside triphosphate pyrophosphohydrolase//RXN0-1041 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="EXOPOLYPHOSPHATASE__45__RXN" name="Exopolyphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1737 ) or ( SG0528_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( exopolyphosphatase ) or ( Multifunctional protein surE [Includes: 5&apos;/3&apos;-nucleotidase (Nucleoside monophosphate phosphohydrolase); Exopolyphosphatase ]//3-NUCLEOTID-RXN//5&apos;-NUCLEOTID-RXN//3&apos;-nucleotidase//Exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOKINASE__45__RXN" name="Fructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG1534 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative carbohydrate kinase (fragment) ) or ( putative carbohydrate kinase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DLACTDEHYDROGNAD__45__RXN" name="D-lactate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-lactate dehydrogenase, FAD-binding, NADH independent (fragment)//D-lactate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: alanine degradation II (to D-lactate)</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.28</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1764_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__262__45__RXN" name="4-hydroxythreonine-4-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0425_pdxA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxythreonine-4-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.262</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGPPHOSPHA__45__RXN" name="Phosphatidylglycerophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0655 ) or ( SG1411 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylglycerophosphatase A ) or ( phosphatidylglycerophosphatase B )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.27</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UPPSYN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1938 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CIS__45__TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PDXJ__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1784 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal phosphate biosynthetic protein PdxJ )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.6.99.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="_1__45__AMINO__45__PROPAN__45__2__45__ONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__69__45__RXN" name="Protein-N(PI)-phosphohistidine-sugar phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or ( SODGM5992_agaD ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused fructose-specific PTS enzymes: IIA component ; HPr component (fragment) ) or ( fused glucose-specific PTS enzymes: IIBcomponent ; IIC component (fragment) ) or ( fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component (fragment) ) or ( fused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component ; IIC component (fragment) ) or ( N-acetylgalactosamine-specific enzyme IID component of PTS ) or ( fused glucose-specific PTS enzymes: IIBcomponent ; IIC component (fragment) ) or ( fused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component ; IIC component (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sugar__124__" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
      <speciesReference species="__124__Sugar__45__Phosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DADP_TO_DATP_COF_RXN" name="DADP_TO_DATP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="DADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" name="L-ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__3__46__20__45__RXN" name="ADP-glyceromanno-heptose 6-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2193_hldD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-L-glycero-D-manno-heptose-6-epimerase (ADP-L- glycero-beta-D-manno-heptose-6-epimerase) (ADP-glyceromanno-heptose 6- epimerase) (ADP-hep 6-epimerase) (AGME) )</html:p>
<html:p>SUBSYSTEM: ADP-L-glycero-&amp;beta;-D-manno-heptose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__D__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__279" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1957 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine sulfinate desulfinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="SULFUR__45__DIOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__SYNTHASE__45__RXN" name="3-dehydroquinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2308_aroB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-dehydroquinate synthase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__3__46__9__45__RXN" name="N-acylglucosamine-6-phosphate 2-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1912 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylmannosamine-6-phosphate 2-epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1062" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__841" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2032 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( coproporphyrinogen III oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.22</html:p>
<html:p>SIDE: CH33ADO</html:p>
<html:p>SIDE: MET</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2621" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2129_uvrA ) or ( SG2342_uvrD ) or ( SG1171_uvrC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( excinuclease ABC subunit A ) or ( DNA-dependent helicase II ) or ( UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.25-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8180" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8534" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2624" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1262_ruvB ) or ( SG1260_ruvC ) or ( SG1261_ruvA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Holliday junction ATP-dependent DNA helicase ruvB ) or ( Holliday junction resolvase//RXN0-2624 ) or ( Holliday junction DNA helicase motor protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.22.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__Combined__45__With__45__Exogenous__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Resolution__45__of__45__Recombinational__45__Junction__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRTRANS__45__RXN" name="Anthranilate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1400_trpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anthranilate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINEKIN__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0973 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine kinase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVIN__45__SYN__45__RXN" name="Riboflavin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0652_ribH ) or ( SG1439 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( riboflavin synthase subunit beta ) or ( riboflavin synthase subunit alpha )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP_TO_UTP_COF_RXN" name="UDP_TO_UTP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4022" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1950_queF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADPH-dependent 7-cyano-7-deazaguanine reductase (7- cyano-7-carbaguanine reductase) (PreQ(0) reductase) (NADPH-dependent nitrile oxidoreductase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_7__45__CYANO__45__7__45__DEAZAGUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__AMINOMETHYL__45__7__45__DEAZAGUANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TEICHOICSYN2__45__RXN" name="N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-&amp;beta;-D- mannosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2374 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative UDP-N-acetyl-D-mannosaminuronic acid transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.187</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__D__45__GLUCOSAMINYLDIPHOSPHO__45__UNDECAPRE" stoichiometry="1"/>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__ETCETERA__45__GLUCOSAMINYLDIPHOSPHOUND" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__50__45__RXN" name="Glutamine--scyllo-inosose aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2378 ) or ( SG1845 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TDP-4-oxo-6-deoxy-D-glucose transaminase ) or ( UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.50</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
      <speciesReference species="CPD__45__365" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__GLUTARAMATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__1105" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IGPSYN__45__RXN" name="indole-3-glycerol-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1399 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.48</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTSEMIALDEHYDROG__45__RXN" name="Glutamate-5-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0601_proA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gamma-glutamyl phosphate reductase (GPR) (Glutamate-5- semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase)//GLUTSEMIALDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1461" name="Coproporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2032 ) or ( SG1712 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( coproporphyrinogen III oxidase ) or ( coproporphyrinogen III oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVFORMLY__45__RXN" name="Formate C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( SG0988 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative pyruvate formate-lyase 3 activating enzyme (fragment) ) or ( putative formate acetyltransferase 2 (pyruvate formate lyase II) (fragment) ) or ( putative formate acetyltransferase 2 (pyruvate formate lyase II) (fragment) ) or ( formate acetyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: reductive monocarboxylic acid cycle</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate IV</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to ethanol I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.54</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THI__45__P__45__KIN__45__RXN" name="Thiamine-phosphate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0654 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamine monophosphate kinase )</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.16</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__10__46__2__45__RXN" name="Non-specific protein-tyrosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0980 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.10.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__2__46__10__45__RXN" name="Phosphoglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0373_glmM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoglucosamine mutase//5.4.2.10-RXN//Phosphoglucosamine mutase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSAMINE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSMANMUT__45__RXN" name="Phosphomannomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1115 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomannomutase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__262" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM5650 ) or ( SG2239 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative molybdopterin-guanine dinucleotide biosynthesis protein A ) or ( putative molybdopterin-guanine dinucleotide biosynthesis protein B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="CPD__45__4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__582" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPRIBOSYLTRAN__45__RXN" name="Adenine phosphoribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0688 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.7</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_DIHYDROFOLATE_COF_RXN" name="METHYLENE-THF_TO_DIHYDROFOLATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UGD__45__RXN" name="UDP-glucose 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1368 ) or ( SG2382_wecC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative UDP-glucose dehydrogenase ) or ( UDP-N-acetyl-D-mannosamine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPRIBOSYLTRAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0482 ) or ( SG0598_gpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine phosphoribosyltransferase ) or ( Xanthine phosphoribosyltransferase (Xanthine-guanine phosphoribosyltransferase) (XGPRT)//XANPRIBOSYLTRAN-RXN//Xanthine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROLINE__45__MULTI" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0601_proA ) or ( SG0600_proB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gamma-glutamyl phosphate reductase (GPR) (Glutamate-5- semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase)//GLUTSEMIALDEHYDROG-RXN ) or ( Glutamate 5-kinase (Gamma-glutamyl kinase) (GK)//GLUTKIN-RXN//Glutamate 5-kinase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7774" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0876_kgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-ketoglutarate decarboxylase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.71</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTAMINOTRANS__45__RXN" name="Histidinol-phosphate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1128 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinol-phosphate aminotransferase HisC )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.9</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0477 ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase ) or ( aconitate hydratase 1 (fragment) ) or ( aconitate hydratase 1 (fragment) ) or ( aconitate hydratase 1 (fragment) ) or ( aconitate hydratase 1 (fragment) )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALGLDAPLIG__45__RXN" name="UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0444_murE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG2397 ) or ( SG2396_ilvM ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetolactate synthase III, large subunit (fragment) ) or ( acetolactate synthase 2 catalytic subunit ) or ( acetolactate synthase 2 regulatory subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN ) or ( acetolactate synthase III, large subunit (fragment) )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDYLATE__45__SYNTHASE__45__RXN" name="Pseudouridylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1053 ) or ( SG0583_rluD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribosomal large subunit pseudouridine synthase C ) or ( 23S rRNA pseudouridine synthase D )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.70</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHOSINEPHOSPHORY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE_TO_L__45__ALPHA__45__ALANINE_COF_RXN" name="PYRUVATE_TO_L-ALPHA-ALANINE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SALICYLATE__45__1__45__MONOOXYGENASE__45__RXN" name="Salicylate 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0076 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative salicylate hydroxylase )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__110" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBPSYN__45__RXN" name="carbamoyl-phosphate synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0420_carB ) or ( SG0419 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbamoyl phosphate synthase large subunit//CARBPSYN-RXN ) or ( carbamoyl-phosphate synthase small subunit )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2417 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-fructose-6-phosphate amidotransferase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.16</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FARNESYLTRANSTRANSFERASE__45__RXN" name="Farnesyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0362 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: geranylgeranyldiphosphate biosynthesis II (plastidic)</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.29</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__HYDRAT__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase-isomerase (fragment) )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOHEMEFERROCHELAT__45__RXN" name="Ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0694_hemH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferrochelatase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDROG__45__RXN" name="Prephenate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0579_tyrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional chorismate mutase/prephenate dehydrogenase//CHORISMATEMUT-RXN//PREPHENATEDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PALMITYL__45__COA_TO_CO__45__A_COF_RXN" name="PALMITYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PALMITYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOHMETRANS__45__RXN" name="glycine hydroxymethyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1775_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine hydroxymethyltransferase (Serine methylase) (SHMT)//GLYOHMETRANS-RXN )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.1</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREONINE__45__ALDOLASE__45__RXN" name="Threonine aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1098 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative L-allo-threonine aldolase )</html:p>
<html:p>SUBSYSTEM: threonine degradation IV</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLGLUTKIN__45__RXN" name="Acetylglutamate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2160_argB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylglutamate kinase (NAG kinase) (AGK) (N-acetyl-L- glutamate 5-phosphotransferase)//ACETYLGLUTKIN-RXN//Acetylglutamate kinase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTURIDYLYLTRANS__45__RXN" name="UDP-glucose--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0896 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative galactose-1-phosphate uridylyltransferase ) or ( galactose-1-phosphate uridylyltransferase (fragment) )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7800" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHGLYSYN__45__RXN" name="Methylglyoxal synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1032_mgsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylglyoxal synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__17__46__1__46__2__45__RXN" name="4-hydroxy-3-methylbut-2-enyl diphosphate reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0417_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__4__45__HYDROXY__45__3__45__METHYLBUT__45__2__45__EN__45__1__45__YL__45__DIPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__3__46__9__45__RXN" name="Phosphoenolpyruvate--protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1702 ) or ( SG1979 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoenolpyruvate-protein phosphotransferase ) or ( fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.3.9</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8675" name="Uroporphyrinogen-III C-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0520 ) or ( SG2368 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( siroheme synthase ) or ( putative uroporphyrinogen III C-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1941" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1982 ) or ( SG0278 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldo/keto reductase ) or ( putative 2,5-diketo-D-gluconate reductase A ) or ( 2,5-diketo-D-gluconate reductase A (fragment) ) or ( putative oxidoreductase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.274</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHYL__45__2__45__METHYLACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHYL__45__2R__45__METHYL__45__3S__45__HYDROXYBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5289" name="2-hydroxy-3-oxopropionate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0507 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative tartronate semialdehyde reductase )</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.60</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITDEH__45__RXN" name="Isocitrate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0700 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THRESYN__45__RXN" name="Threonine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0406 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine synthase )</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENDECARBOX__45__RXN" name="Uroporphyrinogen decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0138_hemE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen decarboxylase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.37</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYM__45__PHOSPH__45__RXN" name="Thymidine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0395_deoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine phosphorylase//THYM-PHOSPH-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="THYMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTONDEHYDRAT__45__RXN" name="Galactonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM0023 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Galactonate dehydratase//Galactonate dehydratase )</html:p>
<html:p>SUBSYSTEM: D-galactonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GALACTONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPSYN__45__RXN" name="Tryptophan synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1397_trpA ) or ( SG1398 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase subunit alpha//TRYPSYN-RXN ) or ( tryptophan synthase subunit beta )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLY3KIN__45__RXN" name="Glycerate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerate kinase I (fragment) ) or ( glycerate kinase II (fragment) ) or ( glycerate kinase I (fragment) ) or ( glycerate kinase I (fragment) )</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.31</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TSA__45__REDUCT__45__RXN" name="2-hydroxy-3-oxopropionate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0507 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative tartronate semialdehyde reductase )</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.60</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0276 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-acyl-glycerol-3-phosphate acyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.51</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA__45__CARBOXYLTRANSFER__45__RXN" name="Acetyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1617 ) or ( SG1927 ) or ( SG0152 ) or ( SG0153 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA carboxylase subunit beta ) or ( acetyl-CoA carboxylase carboxyltransferase subunit alpha ) or ( acetyl-CoA carboxylase biotin carboxylase subunit ) or ( acetyl-CoA carboxylase biotin carboxyl carrier protein subunit )</html:p>
<html:p>SUBSYSTEM: fatty acid biosynthesis - initial steps I</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7958" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG1606 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( propionate kinase/acetate kinase C, anaerobic (fragment) ) or ( acetate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2395 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1764_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5985" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0903 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthase BioB )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5662" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGDECARBOX__45__RXN" name="Arginine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2018 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginine decarboxylase )</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine dependent acid resistance</html:p>
<html:p>SUBSYSTEM: arginine degradation III (arginine decarboxylase/agmatinase pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.19</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AGMATHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5984" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0903 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthase BioB )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: CPD__45__249</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__249" stoichiometry="1"/>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__5662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5293" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0164 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative succinate-semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__6__46__5__46__4__45__RXN" name="Monodehydroascorbate reductase (NADH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative ferredoxin reductase component (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__318" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="OPPSYN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0362 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTPRATPHYD__45__RXN" name="Phosphoribosyl-ATP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1123 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5467" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1120 ) or ( SG1119 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannosyltransferase B ) or ( mannosyltransferase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
      <speciesReference species="CPD__45__5165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5469" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1120 ) or ( SG1119 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannosyltransferase B ) or ( mannosyltransferase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5167" stoichiometry="1"/>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5168" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPYRIMIDINASE__45__RXN" name="Dihydropyrimidinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2133 ) or ( SGP2_0010 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydantoinase ) or ( putative hydantoinase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1120 ) or ( SG1119 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannosyltransferase B ) or ( mannosyltransferase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.132</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__MANNOSYLCHITOBIO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5161" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5463" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1120 ) or ( SG1119 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannosyltransferase B ) or ( mannosyltransferase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5161" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5162" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DETHIOBIOTIN__45__SYN__45__RXN" name="dethiobiotin synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1466 ) or ( SG0906_bioD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dethiobiotin synthase ) or ( dithiobiotin synthetase//DETHIOBIOTIN-SYN-RXN )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPDEHYDROG__45__RXN" name="Mannitol-1-phosphate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0015 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannitol-1-phosphate 5-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: mannitol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.17</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNITOL__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYT__45__UBIQUINOL__45__OXID__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0880 ) or ( SG0665 ) or ( SG0664 ) or ( SG0666 ) or ( SG0881 ) or ( SG0667 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome d ubiquinol oxidase subunit I ) or ( cytochrome o ubiquinol oxidase subunit III ) or ( cytochrome o ubiquinol oxidase subunit IV ) or ( cytochrome o ubiquinol oxidase subunit I ) or ( cytochrome d ubiquinol oxidase subunit II ) or ( cytochrome o ubiquinol oxidase subunit II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Aspartate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2330 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate-semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.11</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TAGAALDOL__45__RXN" name="Tagatose-bisphosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-tagatose 1,6-bisphosphate aldolase 2, catalytic subunit (fragment) ) or ( D-tagatose 1,6-bisphosphate aldolase 2, subunit (fragment) )</html:p>
<html:p>SUBSYSTEM: galactitol degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.40</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAGATOSE__45__1__45__6__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDPHOSDEHYD__45__RXN" name="Imidazoleglycerol-phosphate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1127 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( imidazole glycerol-phosphate dehydratase/histidinol phosphatase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMDECARB__45__RXN" name="Diaminopimelate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1988 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaminopimelate decarboxylase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.20</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPPYPHOSKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0510_relA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP/GTP pyrophosphokinase//GDPPYPHOSKIN-RXN//GTPPYPHOSKIN-RXN )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE__45__5DP__45__3DP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLATECYC__45__RXN" name="Adenylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2347_cyaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylate cyclase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Protein__45__Dithiols__124___TO___124__Protein__45__Disulfides__124___COF_RXN" name="|Protein-Dithiols|_TO_|Protein-Disulfides|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Dithiols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5470" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1046 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosyltransferase MdoH )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5168" stoichiometry="1"/>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5169" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5471" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1046 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosyltransferase MdoH )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
      <speciesReference species="CPD__45__5169" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5170" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAPASYN__45__RXN" name="Adenosylmethionine--8-amino-7-oxononanoate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0902 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosylmethionine--8-amino-7-oxononanoate transaminase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.62</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_8__45__AMINO__45__7__45__OXONONANOATE" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACSERLY__45__RXN" name="Cysteine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1700 ) or ( SODGM1616 ) or (  ) or ( SG1705_cysM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine synthase A ) or ( putative Pyridoxal-phosphate dependent protein ) or ( cysteine synthase B (O-acetylserine sulfhydrolase B) (fragment) ) or ( cysteine synthase B//ACSERLY-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.47</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCHOMOSERLYASE__45__RXN" name="O-succinylhomoserine (thiol)-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2163 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine gamma-synthase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.48</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANPRIBOSYLTRAN__45__RXN" name="Xanthine-guanine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0598_gpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Xanthine phosphoribosyltransferase (Xanthine-guanine phosphoribosyltransferase) (XGPRT)//XANPRIBOSYLTRAN-RXN//Xanthine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.22</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIB5PISOM__45__RXN" name="Ribose 5-phosphate epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2010 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose-5-phosphate isomerase A )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__1__46__6__45__RXN" name="biotin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0903 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthase BioB )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: CH33ADO</html:p>
<html:p>SIDE: MET</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CPD__45__249</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__249" stoichiometry="1"/>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
      <speciesReference species="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="CELLULOSE__45__SYNTHASE__45__GDP__45__FORMING__45__RXN" name="Cellulose synthase (GDP-forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cellulose synthase, catalytic subunit (fragment) ) or ( Cellulose synthase 1 operon protein C precursor (fragment) ) or ( cellulose synthase, catalytic subunit (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.29</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CELLULOSE" stoichiometry="1"/>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__O__45__ACETTRAN__45__RXN" name="Serine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2183_cysE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine acetyltransferase//SERINE-O-ACETTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.30</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOPRIBOTRANS__45__RXN" name="Nicotinate-nucleotide pyrophosphorylase (carboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0464 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinolinate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.19</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__28__45__RXN" name="Tryptophan--phenylpyruvate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1006 ) or ( SG2131 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase ) or ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNREDUC__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0651_ribD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase//RIBOFLAVINSYNDEAM-RXN//RIBOFLAVINSYNREDUC-RXN//5-amino-6-(5-phosphoribosylamino)uracil reductase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.193</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1086" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__P__45__OR__45__NOP_TO_NADH__45__P__45__OR__45__NOP_COF_RXN" name="NAD-P-OR-NOP_TO_NADH-P-OR-NOP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2069 ) or ( SG0250 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arsenate reductase ) or ( arsenate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__296" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOIC__45__ACID" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__763" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__17__45__RXN" name="L-serine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1328 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-serine deaminase )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: L-serine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.17</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAM__45__RXN" name="Phosphoserine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0990 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSGLYPHOS__45__RXN" name="Phosphoglycerate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2015_pgk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPOXANPRIBOSYLTRAN__45__RXN" name="Hypoxanthine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0482 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7839" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase-isomerase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1PFRUCTPHOSN__45__RXN" name="1-phosphofructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0954_fruK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-phosphofructokinase )</html:p>
<html:p>SUBSYSTEM: fructose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.56</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2338 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="LINOLENIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONDEHYDROG__45__RXN" name="Phosphogluconate dehydrogenase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1122 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTPSYN__45__RXN" name="CTP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0512_pyrG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CTP synthase (UTP--ammonia ligase) (CTP synthetase)//CTPSYN-RXN//CTP synthase )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7838" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase-isomerase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cis__45__2__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNDEACET__45__RXN" name="Acetylornithine deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2161 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylornithine deacetylase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROPORIIIMETHYLTRANSA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0520 ) or ( SG2368 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( siroheme synthase ) or ( putative uroporphyrinogen III C-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7933" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2161 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylornithine deacetylase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7224" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0487_panC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pantothenate synthetase (PS) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme)//PANTOATE-BETA-ALANINE-LIG-RXN//Pantoate--beta-alanine ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOYL__45__LACTONE" stoichiometry="1"/>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__GLN__45__RXN" name="NAD(+) synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1866_nadE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD synthetase//NAD-SYNTH-NH3-RXN )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAADEHYDROG__45__RXN" name="D-amino-acid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-amino acid dehydrogenase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THF_TO_METHYLENE__45__THF_COF_RXN" name="THF_TO_METHYLENE-THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7708" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1006 ) or ( SG2131 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase ) or ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7001" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARSENATE" stoichiometry="1"/>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANINE__45__DEAMINASE__45__RXN" name="Guanine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1471 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.3</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5234" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1775_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine hydroxymethyltransferase (Serine methylase) (SHMT)//GLYOHMETRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLO__45__THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYL__45__KIN__45__RXN" name="Guanylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2221_gmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Guanylate kinase (GMP kinase)//GUANYL-KIN-RXN//Guanylate kinase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Acceptor__124___TO___124__Donor__45__H2__124___COF_RXN" name="|Acceptor|_TO_|Donor-H2|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMP__45__DEHYDROG__45__RXN" name="IMP dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1749 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol-5-monophosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.205</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XMPXAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0528_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Multifunctional protein surE [Includes: 5&apos;/3&apos;-nucleotidase (Nucleoside monophosphate phosphohydrolase); Exopolyphosphatase ]//3-NUCLEOTID-RXN//5&apos;-NUCLEOTID-RXN//3&apos;-nucleotidase//Exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINYLDIAMINOPIMTRANS__45__RXN" name="Succinyldiaminopimelate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional acetylornithine aminotransferase and succinyldiaminopimelate aminotransferase (fragment) )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.17</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__SUCCINYL__45__2__45__AMINO__45__6__45__KETOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__SUCCINYLLL__45__2__45__6__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5240" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1775_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine hydroxymethyltransferase (Serine methylase) (SHMT)//GLYOHMETRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIOHBUTANONEPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0263_ribB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,4-dihydroxy-2-butanone 4-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__BUTANONE__45__P" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHITIN__45__DEACETYLASE__45__RXN" name="Chitin deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Chitin deacetylase 1 (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.41</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_14__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYLN1" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__Chitosan__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__200" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__13__46__3__45__RXN" name="Histidine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1581 ) or ( SG0508 ) or ( SG1280 ) or ( SG2231_glnL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hybrid sensory kinase in two-component regulatory system with RcsB and YojN ) or ( hybrid sensory histidine kinase BarA ) or ( putative two-component sensor kinase ) or ( nitrogen regulation protein NR(II) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.13.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3PGAREARR__45__RXN" name="Phosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG0894 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglyceromutase 2, co-factor independent (fragment) ) or ( phosphoglyceromutase 1 ) or ( phosphoglyceromutase 2, co-factor independent (fragment) )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1764_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSEPHOSPHA__45__RXN" name="Trehalose-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1240 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate phosphatase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis II</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis III</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLGLUTPREDUCT__45__RXN" name="N-acetyl-&amp;gamma;-glutamyl-phosphate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM5468_argC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding//N-ACETYLGLUTPREDUCT-RXN )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__469" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URACIL__45__PRIBOSYLTRANS__45__RXN" name="Uracil phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1731_upp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uracil phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__5__45__DEHYDROGENASE__45__RXN" name="Shikimate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2242_aroE ) or ( SODGM5093 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( shikimate 5-dehydrogenase//SHIKIMATE-5-DEHYDROGENASE-RXN ) or ( putative Shikimate 5-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.25</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__ISOPROPYLMALATESYN__45__RXN" name="2-isopropylmalate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0437 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-isopropylmalate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.13</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYRAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1006 ) or ( SG2131 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase ) or ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHORIBULOKINASE__45__RXN" name="Phosphoribulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2299 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribulokinase PrkB )</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.19</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__RIBULOSE__45__15__45__P2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__NUCLEOTID__45__RXN" name="5&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0528_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Multifunctional protein surE [Includes: 5&apos;/3&apos;-nucleotidase (Nucleoside monophosphate phosphohydrolase); Exopolyphosphatase ]//3-NUCLEOTID-RXN//5&apos;-NUCLEOTID-RXN//3&apos;-nucleotidase//Exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPISOM__45__RXN" name="Mannose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1461 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: D-mannose degradation</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMEPIM__45__RXN" name="Diaminopimelate epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2346_dapF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaminopimelate epimerase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__REDUCT__45__NADPH__45__RXN" name="Glutathione reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0068 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione reductase )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions II</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__6__45__RXN" name="Undecaprenyl-phosphate galactosephosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0986 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative UDP-glucose lipid carrier transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="CPD__45__191" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__19__45__RXN" name="Nucleoside-triphosphate pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0511_mazG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside triphosphate pyrophosphohydrolase//RXN0-1041 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7919" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0589_gloB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)//GLYOXII-RXN//Hydroxyacylglutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__hydroxyacyl__45__glutathiones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Hydroxy__45__carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7913" name="Cytidylate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0992_cmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidylate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPONTPRO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0528_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Multifunctional protein surE [Includes: 5&apos;/3&apos;-nucleotidase (Nucleoside monophosphate phosphohydrolase); Exopolyphosphatase ]//3-NUCLEOTID-RXN//5&apos;-NUCLEOTID-RXN//3&apos;-nucleotidase//Exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__NAD__43____45__RXN" name="DNA ligase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1678_ligA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD-dependent DNA ligase LigA//DNA-LIGASE-(NAD(+))-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYISOVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG2394 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydroxy-acid dehydratase (DAD) (fragment)//Dihydroxy-acid dehydratase ) or ( dihydroxy-acid dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CPD__45__558_TO_CO__45__A_COF_RXN" name="CPD-558_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CPD__45__558" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYKIN__45__RXN" name="Diacylglycerol kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0295 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative diacylglycerol kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.107</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETHYLBILANESYN__45__RXN" name="Hydroxymethylbilane synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2366 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( porphobilinogen deaminase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.61</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__70__45__RXN" name="Mannosyl-3-phosphoglycerate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative mannosyl-3-phosphoglycerate phosphatase (mngB-like) (fragment) )</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.70</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__MANNOSYL__45__3__45__PHOSPHOGLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__O__45__ALPHA__45__MANNOSYL__45__D__45__GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__DEHYDROGENASE__45__RXN" name="Glycine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2000 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.1.10</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DURIDKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1371 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative thymidine kinase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOSULFATE__45__SULFURTRANSFERASE__45__RXN" name="Thiosulfate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1765 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative thiosulfate sulfurtransferase )</html:p>
<html:p>SUBSYSTEM: thiosulfate disproportionation III (rhodanese)</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.1</html:p>
<html:p>SIDE: HCN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="1"/>
      <speciesReference species="HCN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="HSCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PFRUCTPHOS__45__RXN" name="6-phosphofructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2178 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructokinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACID__45__PHOSPHATASE__45__RXN" name="Acid phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative phosphatase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__157__45__RXN" name="Glucosamine-1-phosphate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2416_glmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]//2.3.1.157-RXN//NAG1P-URIDYLTRANS-RXN//Glucosamine-1-phosphate N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.157</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCOSAMINE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISPH2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0417_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINOALANINE__45__AMINOTRANSFERASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM5186 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PatA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.1</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__19__45__RXN" name="3-phosphoshikimate 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0991 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-phosphoshikimate 1-carboxyvinyltransferase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.19</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLT_TO_GLN_COF_RXN" name="GLT_TO_GLN_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPH__45__RXN" name="Phosphoglycolate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG0540 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycolate phosphatase (fragment) ) or ( predicted hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__67" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOTHENATE__45__KIN__45__RXN" name="Pantothenate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0126 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantothenate kinase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARTRANSFORM__45__RXN" name="Phosphoribosylaminoimidazolecarboxamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0143 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazolecarboxamide formyltransferase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.3</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AICAR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLACYLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase-isomerase (fragment) )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DXPREDISOM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1939 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose 5-phosphate reductoisomerase )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.267</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNA__45__RXN" name="Aspartate--ammonia ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0813_asnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine synthetase B )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine.</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( SG1715 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase 2, thiamin-binding (fragment) ) or ( transketolase 1, thiamin-binding (fragment) ) or ( transketolase 1, thiamin-binding (fragment) ) or ( transketolase ) or ( transketolase 2, thiamin-binding (fragment) )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__148__45__RXN" name="4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1879_ispE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (4-(cytidine-5&apos;-diphospho)-2-C-methyl-D-erythritol kinase)//2.7.1.148-RXN )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.148</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5822" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative phosphatase (fragment) )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRROLINEDEH__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1243_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__CH3__45__2__45__OXOBUTANOATE__45__OH__45__CH3__45__XFER__45__RXN" name="3-methyl-2-oxobutanoate hydroxymethyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0488_panB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase) (KPHMT)//3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN//3-methyl-2-oxobutanoate hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.11</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: METHYLENE__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTCYCLOHYD__45__RXN" name="Phosphoribosyl-AMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1123 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2373 ) or ( SODGM2577 ) or ( SG0897 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative sugar-nucleotide epimerase/dehydratase ) or ( putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( UDP-galactose-4-epimerase )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__64__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1583_ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-demethylubiquinone-9 3-methyltransferase (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (DHHB methyltransferase)//DHHB-METHYLTRANSFER-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LTAA__45__RXN" name="L-allo-threonine aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1775_glyA ) or ( SG1098 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine hydroxymethyltransferase (Serine methylase) (SHMT)//GLYOHMETRANS-RXN ) or ( putative L-allo-threonine aldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALLO__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKAPHOSPHA__45__RXN" name="Alkaline phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1374_oppB ) or ( SG0061 ) or ( SG0881 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oligopeptide transporter permease ) or ( dipeptide transporter permease DppB ) or ( cytochrome d ubiquinol oxidase subunit II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__6__45__OHPHENOL__45__METHY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1583_ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-demethylubiquinone-9 3-methyltransferase (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (DHHB methyltransferase)//DHHB-METHYLTRANSFER-RXN )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__METHOXYPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOBUTFORMLY__45__RXN" name="formate C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( SG0988 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative pyruvate formate-lyase 3 activating enzyme (fragment) ) or ( putative formate acetyltransferase 2 (pyruvate formate lyase II) (fragment) ) or ( putative formate acetyltransferase 2 (pyruvate formate lyase II) (fragment) ) or ( formate acetyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: threonine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__LACTAMASE__45__RXN" name="&amp;beta;-lactamase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1809 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Beta-lactamase//Beta-lactamase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__Lactams__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8550" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNI__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1751 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate:quinone oxidoreductase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.16</html:p>
<html:p>SIDE: VITAMIN_K_2</html:p>
<html:p>SIDE: REDUCED__45__MENAQUINONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VITAMIN_K_2" stoichiometry="1"/>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
      <speciesReference species="REDUCED__45__MENAQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLT_TO_2__45__KETOGLUTARATE_COF_RXN" name="GLT_TO_2-KETOGLUTARATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARABISOM__45__RXN" name="L-arabinose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-arabinose isomerase (fragment)//L-arabinose isomerase )</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__RIBULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONOLACT__45__RXN" name="6-phosphogluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0900_pgl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase (6-P-gluconolactonase)//6PGLUCONOLACT-RXN//6-phosphogluconolactonase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRNA__45__PSEUDOURIDINE__45__SYNTHASE__45__I__45__RXN" name="tRNA-pseudouridine synthase I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1619_truA ) or ( SG0429 ) or ( SG0379 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA pseudouridine synthase A//TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN ) or ( ribosomal large subunit pseudouridine synthase A ) or ( tRNA pseudouridine synthase B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8538" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8537" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_ADP_COF_RXN" name="ATP_TO_ADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEPHOSPHOCOAKIN__45__RXN" name="Dephospho-CoA kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0461_coaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dephospho-CoA kinase (Dephosphocoenzyme A kinase)//DEPHOSPHOCOAKIN-RXN//Dephospho-CoA kinase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__11__46__1__46__15__45__RXN" name="Peroxiredoxin" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0642 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative peroxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="2"/>
      <speciesReference species="__124__Alkyl__45__Hydro__45__Peroxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCISOM__45__RXN" name="Glucose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2146_pgi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)//PGLUCISOM-RXN//Glucose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: sucrose degradation IV</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2203 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-D-manno-octulosonic-acid transferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: KDO transfer to lipid IVA</html:p>
<html:p>PROTEIN_CLASS: 2.-.-.-</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LIPID__45__IV__45__A" stoichiometry="1"/>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO__45__LIPID__45__IVA" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMET__45__RXN" name="5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0092 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.14</html:p>
<html:p>SIDE: CPD__45__1301</html:p>
<html:p>SIDE: CPD__45__1302</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1302" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1301" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPACYLGLCNACDEACETYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0454_lpxC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__OHMYR__45__ACETYLGLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="UDP__45__OHMYR__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8748" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1374_oppB ) or ( SG0061 ) or ( SG0881 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oligopeptide transporter permease ) or ( dipeptide transporter permease DppB ) or ( cytochrome d ubiquinol oxidase subunit II )</html:p>
<html:p>SUBSYSTEM: diethylphosphate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ETOH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8978" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTKIN__45__RXN" name="Glutamate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0600_proB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutamate 5-kinase (Gamma-glutamyl kinase) (GK)//GLUTKIN-RXN//Glutamate 5-kinase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYKI__45__RXN" name="Thymidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1371 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative thymidine kinase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITSYN__45__RXN" name="Citrate (si)-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0871_gltA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( type II citrate synthase//CITSYN-RXN )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5200" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0009_avtA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( valine--pyruvate transaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="an__32__amine__32__donor" stoichiometry="1"/>
      <speciesReference species="__124__Amineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3686" stoichiometry="1"/>
      <speciesReference species="__124__Deamineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
      <speciesReference species="deaminated__32__donor" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULP3EPIM__45__RXN" name="ribulose phosphate 3-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2305 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribulose-phosphate 3-epimerase )</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation II</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPIDADISACCHARIDESYNTH__45__RXN" name="Lipid-A-disaccharide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1930_lpxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Lipid-A-disaccharide synthase//LIPIDADISACCHARIDESYNTH-RXN//Lipid-A-disaccharide synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.182</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BISOHMYR__45__GLUCOSAMINYL__45__1P" stoichiometry="1"/>
      <speciesReference species="OH__45__MYRISTOYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BISOHMYR__45__GLC" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4361" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1914 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D,D-heptose 1,7-bisphosphate phosphatase )</html:p>
<html:p>SUBSYSTEM: ADP-L-glycero-&amp;beta;-D-manno-heptose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__BETA__45__D__45__HEPTOSE__45__17__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__BETA__45__D__45__HEPTOSE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHHB__45__METHYLTRANSFER__45__RXN" name="3-demethylubiquinone-9 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1583_ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-demethylubiquinone-9 3-methyltransferase (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (DHHB methyltransferase)//DHHB-METHYLTRANSFER-RXN )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__OH__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINKIN__45__RXN" name="Riboflavin kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0413 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional riboflavin kinase/FMN adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: 5,6-dimethylbenzimidazole biosynthesis</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Fatty__45__Acyl__45__CoA__124___TO_CO__45__A_COF_RXN" name="|Fatty-Acyl-CoA|_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16BDEPHOS__45__RXN" name="Fructose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0356 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-1,6-bisphosphatase ) or ( fructose 1,6-bisphosphatase II (fragment) ) or ( fructose 1,6-bisphosphatase II (fragment) )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYGLUCONOKIN__45__RXN" name="2-dehydro-3-deoxygluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0067 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ketodeoxygluconokinase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.45</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__20__45__RXN" name="Methylenetetrahydrofolate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2162_metF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5,10-methylenetetrahydrofolate reductase//1.5.1.20-RXN )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.20</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SIROHEME__45__FERROCHELAT__45__RXN" name="Sirohydrochlorin ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0520 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( siroheme synthase )</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPMANDEHYDRA__45__RXN" name="GDP-mannose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative GDP-mannose dehydratase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-&amp;alpha;-D-perosamine biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-6-deoxy-D-talose biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-D-rhamnose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.47</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCHORMAT__45__RXN" name="Isochorismatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1256 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative isochorismatase )</html:p>
<html:p>SUBSYSTEM: enterobactin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOCHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRO__45__DIOH__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEHYDR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0477 ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase ) or ( aconitate hydratase 1 (fragment) ) or ( aconitate hydratase 1 (fragment) ) or ( aconitate hydratase 1 (fragment) ) or ( aconitate hydratase 1 (fragment) )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-D-GLUCOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTEPADENYLYLTRAN__45__RXN" name="Pantetheine-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2205 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphopantetheine adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.3</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5114" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0398_serB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine phosphatase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5118" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2195 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-heptose:LPS heptosyl transferase I )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.-.-</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
      <speciesReference species="KDO2__45__LIPID__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__929" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_7KAPSYN__45__RXN" name="8-amino-7-oxononanoate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0904 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 8-amino-7-oxononanoate synthase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.47</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CPD__45__558</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_8__45__AMINO__45__7__45__OXONONANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__1__46__8__45__RXN" name="Lipoyl synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0792 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipoyl synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
      <speciesReference species="S8" stoichiometry="2"/>
      <speciesReference species="__124__Protein__45__6__45__N__45__octanoyl__45__lysine__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="MET" stoichiometry="2"/>
      <speciesReference species="__124__Protein__45__6__45__N__45__lipoyl__45__lysine__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DECAPCISTRANSFER__45__RXN" name="di-trans-poly-cis-decaprenylcistransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1938 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="T__45__POLY__45__C__45__DECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="T__45__POLY__45__C__45__UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNCARBAMTRANSFER__45__RXN" name="Ornithine carbamoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2113 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine carbamoyltransferase subunit I )</html:p>
<html:p>SUBSYSTEM: citrulline degradation</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDRAT__45__RXN" name="Prephenate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0580_pheA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional chorismate mutase/prephenate dehydratase//CHORISMATEMUT-RXN//PREPHENATEDEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.51</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINSYN__45__RXN" name="argininosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM3780_argG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate synthetase//ARGSUCCINSYN-RXN )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXINE__45__4__45__DEHYDROGENASE__45__RXN" name="Pyridoxine 4-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM4467 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Pyridoxine 4-dehydrogenase//Pyridoxine 4-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.65</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__HEXADECENAL__45__REDUCTASE__45__RXN" name="2-hexadecenal reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0212 ) or ( SG0213 ) or ( SG0811 ) or ( SG0505 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine endoprotease ) or ( serine protease ) or ( putative tRNA-thiotransferase ) or ( serine endoprotease ) or ( D-galactose transporter (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.27</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__292" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMITALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOLINATE__45__SYNTHA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0889 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinolinate synthetase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: DIHYDROXY__45__ACETONE__45__PHOSPHATE</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="IMINOASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIP__45__KIN__45__RXN" name="Nucleoside-diphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1764_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__68__45__RXN" name="2-deoxyglucose-6-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1604 ) or ( SG1987 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphatase ) or ( putative phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.68</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEOXY__45__D__45__GLUCOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEOXY__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCARDEHYDRA__45__RXN" name="Glucarate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0506 ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glucarate dehydratase ) or ( (D)-glucarate dehydratase 1 (fragment) ) or ( (D)-glucarate dehydratase 1 (fragment) ) or ( (D)-glucarate dehydratase 1 (fragment) )</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.40</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__KETO__45__4__45__DEOXY__45__D__45__GLUCARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1769 ) or ( SG1957 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aminotransferase ) or ( cysteine sulfinate desulfinase )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ENZYME__45__S__45__SULFANYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIOSEPISOMERIZATION__45__RXN" name="Triosephosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2176_tpiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Triosephosphate isomerase (TIM) (Triose-phosphate isomerase)//TRIOSEPISOMERIZATION-RXN//Triose-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5226" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1953 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.52</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__882" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__305" name="Hydroxypyruvate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM5081 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Hydroxypyruvate isomerase//Hydroxypyruvate isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5225" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0334 ) or ( SG1961 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylmuramoyl-l-alanine amidase II ) or ( N-acetylmuramoyl-L-alanine amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1080" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1082" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__302" name="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0527_ispF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS) (MECDP-synthase)//RXN0-302//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.12</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEHYDROGENASE__45__ACCEPTOR__45__RXN" name="Malate dehydrogenase (acceptor)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1751 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate:quinone oxidoreductase )</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TIGLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase-isomerase (fragment) )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FADSYN__45__RXN" name="FMN adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0413 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional riboflavin kinase/FMN adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.2</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2NEOPTERINALDOL__45__RXN" name="Dihydroneopterin aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0256 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroneopterin aldolase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.25</html:p>
<html:p>SIDE: GLYCOLALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__NEO__45__PTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
      <speciesReference species="GLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPIDXSYNTHESIS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM0136_cdh ) or ( SG0703 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diacylglycerol phosphotidylhydrolase//CDPDIGLYPYPHOSPHA-RXN ) or ( UDP-2,3-diacylglucosamine hydrolase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__MYRISTOYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BISOHMYR__45__GLUCOSAMINYL__45__1P" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__80__45__RXN" name="N-acetylgalactosamine-6-phosphate deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0815_nagA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine-6-phosphate deacetylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPAMIDOTRANS__45__RXN" name="Amidophosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1613 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidophosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.14</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDP_TO_CTP_COF_RXN" name="CDP_TO_CTP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxybutyrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1486 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative short-chain dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.30</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__335" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOSEPHOSPHO__45__RXN" name="Protein-N(PI)-phosphohistidine-sugar phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or ( SODGM5992_agaD ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused fructose-specific PTS enzymes: IIA component ; HPr component (fragment) ) or ( fused glucose-specific PTS enzymes: IIBcomponent ; IIC component (fragment) ) or ( fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component (fragment) ) or ( fused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component ; IIC component (fragment) ) or ( N-acetylgalactosamine-specific enzyme IID component of PTS ) or ( fused glucose-specific PTS enzymes: IIBcomponent ; IIC component (fragment) ) or ( fused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component ; IIC component (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__12__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0515 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 6-pyruvoyl tetrahydrobiopterin synthase )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.12</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIAZOLSYN3__45__RXN" name="Hydroxyethylthiazole kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1739 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative hydoxyethylthiazole kinase )</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.50</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THZ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THZ__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYLGLUCOSAMINE__45__4__45__EPIMERASE__45__RXN" name="UDP-N-acetylglucosamine 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM2577 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7241" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG1350 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit ; periplasmic-binding component of ABC superfamily (fragment) ) or ( protease 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6741" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPDEPHOS__45__RXN" name="Pyruvate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1268 ) or ( SG1438 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate kinase ) or ( pyruvate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.40</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBDEHYDROG__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1243_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1083 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase-isomerase (fragment) )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOENOLPYRUVATE__45__MUTASE__45__RXN" name="Phosphoenolpyruvate mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphonopyruvate hydrolase precursor (fragment) )</html:p>
<html:p>SUBSYSTEM: fosfomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__235" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOPORGENOXI__45__RXN" name="Protoporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0121_hemG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoporphyrinogen oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLU6PDEHYDROG__45__RXN" name="Glucose-6-phosphate 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1270 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate 1-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.49</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8642" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0700 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PABASYN__45__RXN" name="Aminodeoxychorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2302 ) or ( SG1329 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( para-aminobenzoate synthase component II ) or ( para-aminobenzoate synthase component I )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.8</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEPHOSPHORYLATION__45__RXN" name="5&apos;-nucleotidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0528_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Multifunctional protein surE [Includes: 5&apos;/3&apos;-nucleotidase (Nucleoside monophosphate phosphohydrolase); Exopolyphosphatase ]//3-NUCLEOTID-RXN//5&apos;-NUCLEOTID-RXN//3&apos;-nucleotidase//Exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2113 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine carbamoyltransferase subunit I )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: CARBAMOYL__45__P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATEKIN__45__RXN" name="Aspartate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2147 ) or ( SG0404_thrA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate kinase III ) or ( bifunctional aspartokinase I/homeserine dehydrogenase I//ASPARTATEKIN-RXN ) or ( fused aspartokinase II ; homoserine dehydrogenase II (fragment) )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UMPKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0992_cmk ) or ( SG1941_pyrH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidylate kinase ) or ( uridylate kinase )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSDECARB__45__RXN" name="Phosphopantothenoylcysteine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2209 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.36</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTERIDINEPYROPHOSPHOKIN__45__RXN" name="2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0489 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDPGALDOL__45__RXN" name="2-dehydro-3-deoxyphosphogluconate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase (fragment) )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DARAB5PISOM__45__RXN" name="Arabinose-5-phosphate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0204 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-arabinose 5-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARABINOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4301" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0595_gmhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoheptose isomerase )</html:p>
<html:p>SUBSYSTEM: ADP-L-glycero-&amp;beta;-D-manno-heptose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALPHABETA__45__D__45__HEPTOSE__45__7__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTALDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1129_hisD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FGAMSYN__45__RXN" name="phosphoribosylformylglycinamidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1778_purL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoribosylformylglycinamidine synthase (FGAM synthase) (FGAMS) (Formylglycinamide ribotide amidotransferase) (FGARAT) (Formylglycinamide ribotide synthetase)//FGAMSYN-RXN//Phosphoribosylformylglycinamidine synthase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__NH3__45__RXN" name="NAD(+) synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1866_nadE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD synthetase//NAD-SYNTH-NH3-RXN )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTPPYPHOSKIN__45__RXN" name="GTP diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0510_relA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP/GTP pyrophosphokinase//GDPPYPHOSKIN-RXN//GTPPYPHOSKIN-RXN )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__TP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5306" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM5019_yiiL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-rhamnose mutarotase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RHAMNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1112" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLYLSULFKIN__45__RXN" name="Adenylylsulfate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0523 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylylsulfate kinase )</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.25</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_PROPIONYL__45__COA_COF_RXN" name="CO-A_TO_PROPIONYL-COA_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCC__45__FUM__45__OXRED__45__RXN" name="Succinate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG0874_sdhA ) or ( SG0875_sdhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarate reductase (anaerobic), Fe-S subunit (fragment) ) or ( succinate dehydrogenase flavoprotein subunit ) or ( succinate dehydrogenase iron-sulfur subunit )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZOQ__45__OH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0812_ubiF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__OH__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="POLYPHOSPHATE__45__KINASE__45__RXN" name="Polyphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1736 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyphosphate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8635" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1728_bcp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thioredoxin-dependent thiol peroxidase//PEROXID-RXN )</html:p>
<html:p>SUBSYSTEM: betanidin degradation</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.7</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8653" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8890" stoichiometry="1"/>
      <speciesReference species="CPD__45__8653" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETRAACYLDISACC4KIN__45__RXN" name="Tetraacyldisaccharide 4&apos;-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0996_lpxK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tetraacyldisaccharide 4&apos;-kinase (Lipid A 4&apos;-kinase)//TETRAACYLDISACC4KIN-RXN//Tetraacyldisaccharide 4&apos;-kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.130</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BISOHMYR__45__GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPID__45__IV__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALARACECAT__45__RXN" name="Alanine racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1342 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alanine racemase )</html:p>
<html:p>SUBSYSTEM: alanine degradation I</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8631" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2014 ) or ( SG1113 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-bisphosphate aldolase ) or ( UTP-glucose-1-phosphate uridylyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__7__46__1__46__13__45__RXN" name="Queuine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1950_queF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADPH-dependent 7-cyano-7-deazaguanine reductase (7- cyano-7-carbaguanine reductase) (PreQ(0) reductase) (NADPH-dependent nitrile oxidoreductase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.13</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUEUINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8988" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2202 ) or ( SG0312_psd ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative lipopolysaccharide glycosyltransferase ) or ( Phosphatidylserine decarboxylase proenzyme [Contains: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]//PHOSPHASERDECARB-RXN//Phosphatidylserine decarboxylase ) or ( Glycosyl transferase, group 1 (fragment) )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.65</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5061" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2194 ) or ( SG2195 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-heptose:LPS heptosyltransferase II ) or ( ADP-heptose:LPS heptosyl transferase I )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__929" stoichiometry="1"/>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="CPD0__45__930" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDUD__45__RXN" name="2-deoxy-D-gluconate 3-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM3351 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-deoxy-D-gluconate 3-dehydrogenase//2-deoxy-D-gluconate 3-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.125</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DE__45__O__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DE__45__O__45__K__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__36__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (GDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1241 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.36</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCGLU__45__SEMIALDEHYDE__45__SUCCGLU__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1243_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__SUCCINYLGLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5057" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2195 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-heptose:LPS heptosyl transferase I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
      <speciesReference species="KDO2__45__LIPID__45__IVA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="HEPTOSYL__45__KDO2__45__LIPID__45__IVA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCOSEPP__45__RXN" name="Glucose-1-phosphate thymidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2380 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-1-phosphate thymidylyltransferase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.24</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTASE__45__RXN" name="Aspartate ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0303 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aspartate ammonia-lyase )</html:p>
<html:p>SUBSYSTEM: glutamate degradation II</html:p>
<html:p>SUBSYSTEM: superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine.</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARDIOLIPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( SG1378_cls )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cardiolipin synthase 2 (fragment) ) or ( cardiolipin synthase 2 (fragment) ) or ( cardiolipin synthetase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>SIDE: GLYCEROL</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARDIOLIPIN" stoichiometry="1"/>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSHTRAN__45__RXN" name="Glutathione transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1609 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glutathione S-transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RX" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HX" stoichiometry="1"/>
      <speciesReference species="__124__S__45__Substituted__45__Glutathione__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG1585_nrdB ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleoside-diphosphate reductase 2, alpha subunit (fragment) ) or ( ribonucleotide-diphosphate reductase subunit beta//ADPREDUCT-RXN//CDPREDUCT-RXN//GDPREDUCT-RXN//RIBONUCLEOSIDE-DIP-REDUCTI-RXN//UDPREDUCT-RXN ) or ( ribonucleoside-diphosphate reductase 2, alpha subunit (fragment) ) or ( ribonucleoside-diphosphate reductase 2, alpha subunit (fragment) ) or ( ribonucleoside-diphosphate reductase 2, alpha subunit (fragment) ) or ( ribonucleoside-diphosphate reductase 2, beta subunit, ferritin-like (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.4.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxy__45__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMIDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1126_hisH ) or ( SG1124 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( imidazole glycerol phosphate synthase subunit HisH ) or ( imidazole glycerol phosphate synthase subunit HisF )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATEPRIBOSYLTRANS__45__RXN" name="Nicotinate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1016 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.11</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCHORSYN__45__RXN" name="Isochorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isochorismate synthase 2 (fragment) ) or ( isochorismate synthase 2 (fragment) )</html:p>
<html:p>SUBSYSTEM: menaquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: enterobactin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 5.4.4.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOCHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPICRED__45__RXN" name="Dihydrodipicolinate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0418 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrodipicolinate reductase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.26</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1764_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYRIBOSE__45__P__45__ALD__45__RXN" name="Deoxyribose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0394 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyribose-phosphate aldolase )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8447" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__AMINO__45__PROPAN__45__2__45__ONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG1P__45__URIDYLTRANS__45__RXN" name="UDP-N-acetylglucosamine pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2416_glmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]//2.3.1.157-RXN//NAG1P-URIDYLTRANS-RXN//Glucosamine-1-phosphate N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.23</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2201" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-allo-threonine dehydrogenase, NAD(P)-binding )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.276</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOMALONATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__2__46__10__45__RXN" name="UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0445_murF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase//UDP-NACMURALGLDAPAALIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__209" stoichiometry="1"/>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="Myo-inositol-1(or 4)-monophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0350 ) or ( SG1772 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PAPS (adenosine 3&apos;-phosphate 5&apos;-phosphosulfate) 3&apos;(2&apos;),5&apos;-bisphosphate nucleotidase ) or ( inositol monophosphatase )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLCNACPTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2385 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLCNAC__45__PP__45__LIPID" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINE__45__NUCLEOSIDASE__45__RXN" name="Adenosylhomocysteine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0503 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-methylthioadenosine/S-adenosylhomocysteine nucleosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__564" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALA__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1886 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( periplasmic trehalase )</html:p>
<html:p>SUBSYSTEM: trehalose degradation II (trehalase)</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.28</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="PORPHOBILSYNTH__45__RXN" name="Porphobilinogen synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1529 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-aminolevulinic acid dehydratase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.24</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETATEKIN__45__RXN" name="Acetate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG1606 ) or ( SG1272_purT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( propionate kinase/acetate kinase C, anaerobic (fragment) ) or ( acetate kinase ) or ( phosphoribosylglycinamide formyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: acetate formation from acetyl-CoA I</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate II</html:p>
<html:p>SUBSYSTEM: acetylene degradation</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate IV</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__41__45__RXN" name="Bis(5&apos;-nucleosyl)-tetraphosphatase (symmetrical)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0422_apaH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diadenosine tetraphosphatase//3.6.1.41-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.41</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__P4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTMPKI__45__RXN" name="Thymidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1065_tdk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate kinase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OXOGLUT__45__DECARBOX__45__RXN" name="2-oxoglutarate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0876_kgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-ketoglutarate decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.71</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCCINATE__45__SEMIALDEHYDE__45__THIAMINE__45__PPI" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5180" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1938 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYGUANPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYGUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBREDUCT__45__RXN" name="Pyrroline-5-carboxylate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2028 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrroline-5-carboxylate reductase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPCARBTRANS__45__RXN" name="Aspartate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2115_pyrB ) or ( SG2116 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aspartate carbamoyltransferase (Aspartate transcarbamylase) (ATCase)//ASPCARBTRANS-RXN//Aspartate carbamoyltransferase ) or ( aspartate carbamoyltransferase regulatory subunit )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.2</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2101 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catalase )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ERYTHRON4PDEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1621_pdxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Erythronate-4-phosphate dehydrogenase//ERYTHRON4PDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.290</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ERYTHRONATE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3OH__45__4P__45__OH__45__ALPHA__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYMETVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG2394 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydroxy-acid dehydratase (DAD) (fragment)//Dihydroxy-acid dehydratase ) or ( dihydroxy-acid dehydratase )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8925" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1769 ) or ( SG1250 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aminotransferase ) or ( putative aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="an__32__amine__32__donor" stoichiometry="1"/>
      <speciesReference species="VANILLIN" stoichiometry="1"/>
      <speciesReference species="__124__Amineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="deaminated__32__donor" stoichiometry="1"/>
      <speciesReference species="CPD__45__9327" stoichiometry="1"/>
      <speciesReference species="__124__Deamineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8442" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="D__45__RIBULOSE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8259" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GARTRANSFORMYL2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG1272_purT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase 1 (fragment) ) or ( phosphoribosylglycinamide formyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINLYA__45__RXN" name="Argininosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2159_argH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Argininosuccinate lyase (Arginosuccinase) (ASAL)//ARGSUCCINLYA-RXN//Argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRCARBOXY__45__RXN" name="Phosphoribosylaminoimidazole carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0702 ) or ( SG0701 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase catalytic subunit ) or ( phosphoribosylaminoimidazole carboxylase ATPase subunit )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.21</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DALADALALIG__45__RXN" name="D-alanine--D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0899 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-alanine-D-alanine ligase A ) or ( D-alanine-D-alanine ligase A (fragment) ) or ( D-alanine-D-alanine ligase A (fragment) )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYINOPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYINOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPNACETYLGLUCOSAMENOLPYRTRANS__45__RXN" name="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0211 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine 1-carboxyvinyltransferase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.7</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8813" name="Trans-pentaprenyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0362 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6841" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2329_glpD ) or ( SG2184_gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase//GLYC3PDEHYDROG-RXN ) or ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXII__45__RXN" name="Hydroxyacylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0589_gloB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)//GLYOXII-RXN//Hydroxyacylglutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NAD__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0967 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD-linked malate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.38</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOSYLHOMOCYSTEINASE__45__RXN" name="Ribosylhomocysteinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0542_luxS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-ribosylhomocysteine lyase (Autoinducer-2 production protein luxS) (AI-2 synthesis protein)//RIBOSYLHOMOCYSTEINASE-RXN//S-ribosylhomocysteine lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__564" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="DIHYDROXYPENTANEDIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PPENTOMUT__45__RXN" name="Phosphopentomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0396_deoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphopentomutase (Phosphodeoxyribomutase)//D-PPENTOMUT-RXN//PPENTOMUT-RXN//Phosphopentomutase )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NACGLCTRANS__45__RXN" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0449_murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosaminyl transferase//NACGLCTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C5" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DXS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0656_dxs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose-5-phosphate synthase (1-deoxyxylulose- 5-phosphate synthase) (DXP synthase) (DXPS)//DXS-RXN//1-deoxy-D-xylulose-5-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.7</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALDEHYDROG__45__RXN" name="3-isopropylmalate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0436_leuB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)//3-ISOPROPYLMALDEHYDROG-RXN//3-isopropylmalate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.85</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase-isomerase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMEOSYN__45__RXN" name="heme o biosynthesis" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0663 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoheme IX farnesyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEME_O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCDEHYDROG__45__RXN" name="Phosphoglycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2009 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-3-phosphoglycerate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.95</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTCYSLIG__45__RXN" name="Glutamate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0541 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate--cysteine ligase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METBALT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2163 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine gamma-synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.48</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PPPGPPHYDRO__45__RXN" name="Guanosine-5&apos;-triphosphate,3&apos;-diphosphate pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1737 ) or ( SG2389 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( exopolyphosphatase ) or ( guanosine pentaphosphate phosphohydrolase )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.40</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__TP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE__45__5DP__45__3DP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RHAMNULPALDOL__45__RXN" name="Rhamnulose-1-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2025 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative rhamnulose-1-phosphate aldolase ) or ( rhamnulose-1-phosphate aldolase (fragment) )</html:p>
<html:p>SUBSYSTEM: rhamnose degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RHAMNULOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTALD" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNONOXIDOREDUCT__45__RXN" name="Fructuronate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1837 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative mannonate oxidoreductase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.57</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__MANNONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMPSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1083 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENIIISYN__45__RXN" name="uroporphyrinogen-III synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2367_hemD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen-III synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.75</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_10__45__FORMYL__45__THF_TO_THF_COF_RXN" name="10-FORMYL-THF_TO_THF_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADCLY__45__RXN" name="Aminodeoxychorismate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1063 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-amino-4-deoxychorismate lyase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.38</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5199" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM1034_deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase//ADENPHOSPHOR-RXN//INOPHOSPHOR-RXN//PNP-RXN )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETHYDPICSUCC__45__RXN" name="2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1946_dapD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase//TETHYDPICSUCC-RXN )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.117</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__SUCCINYL__45__2__45__AMINO__45__6__45__KETOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TAGAKIN__45__RXN" name="Tagatose-6-phosphate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG0177 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-tagatose 1,6-bisphosphate aldolase 2, subunit (fragment) ) or ( putative tagatose 6-phosphate kinase )</html:p>
<html:p>SUBSYSTEM: galactitol degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.144</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAGATOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAGATOSE__45__1__45__6__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP cyclohydrolase I" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0957_folE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP cyclohydrolase I )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.16</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATEREDUCT__45__RXN" name="Dihydrofolate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0421_folA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__A2__45__RXN" name="Phospholipase A2" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2338 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase A )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.4</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R__45__2__45__METHYLMALATE__45__DEHYDRATASE__45__RXN" name="(R)-2-methylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0435 ) or ( SG0434_leuD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopropylmalate isomerase large subunit ) or ( isopropylmalate isomerase small subunit//3-ISOPROPYLMALISOM-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.35</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__31" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYLMALEATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__60__45__RXN" name="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0526_ispD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT)//2.7.7.60-RXN//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.60</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMSUCTRAN__45__RXN" name="Homoserine O-succinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2152 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoserine O-succinyltransferase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.46</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCTP__45__DEAM__45__RXN" name="dCTP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0974_dcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxycytidine triphosphate deaminase//DCTP-DEAM-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.13</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPCARBOXYKIN__45__RXN" name="Phosphoenolpyruvate carboxykinase (ATP)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2317_pckA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoenolpyruvate carboxykinase [ATP] (PEP carboxykinase) (Phosphoenolpyruvate carboxylase) (PEPCK) )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.49</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3522" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative ferredoxin reductase component (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.4</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__318" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2142 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate acyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.15</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNDEAM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0651_ribD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase//RIBOFLAVINSYNDEAM-RXN//RIBOFLAVINSYNREDUC-RXN//5-amino-6-(5-phosphoribosylamino)uracil reductase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.26</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM__45__RXN" name="Cytidine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0968 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUTP__45__PYROP__45__RXN" name="dUTP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2210_dut ) or ( SG0511_mazG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyuridine 5&apos;-triphosphate nucleotidohydrolase//DUTP-PYROP-RXN ) or ( nucleoside triphosphate pyrophosphohydrolase//RXN0-1041 )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCDEHYDRAT__45__RXN" name="dTDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2381 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-D-glucose-4,6-dehydratase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.46</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAHPSYN__45__RXN" name="2-dehydro-3-deoxyphosphoheptonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0893 ) or ( SG1427 ) or ( SG0578 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospho-2-dehydro-3-deoxyheptonate aldolase ) or ( phospho-2-dehydro-3-deoxyheptonate aldolase ) or ( phospho-2-dehydro-3-heoxyheptonate aldolase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.54</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNB__45__RXN" name="asparagine synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0813_asnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine synthetase B )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine.</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.4</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="adenylosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0342 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate synthetase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.4</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMACTRANS__45__RXN" name="Diamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1899 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine N1-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aliphatic__45__N__45__Acetyl__45__Diamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOGLUCMUT__45__RXN" name="Phosphoglucomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0866 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglucomutase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation IV</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2146_pgi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)//PGLUCISOM-RXN//Glucose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEH__45__RXN" name="Malate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM0972 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Malate dehydrogenase//Malate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: aspartate degradation II</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.37</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__821" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1243_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACYLNEURAMINATE__45__9__45__PHOSPHATASE__45__RXN" name="N-acylneuraminate-9-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2343 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( predicted hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.29</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1119" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNPOXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1447_pdxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyridoxamine 5&apos;-phosphate oxidase (PNP/PMP oxidase) (PNPOx)//PMPOXI-RXN//PNPOXI-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA_TO_CO__45__A_COF_RXN" name="ACETYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SELENOCYSTEINE__45__LYASE__45__RXN" name="Selenocysteine lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1435 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative selenocysteine lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__SELENOCYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__678" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0706_folD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofolate cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5727" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="ribose-phosphate diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1880 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose-phosphate pyrophosphokinase )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__76__45__RXN" name="Diaminobutyrate-2-oxoglutarate transaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SGP1_0046 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaminobutyrate--2-oxoglutarate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.76</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__470" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUC4NACTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2376 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-alpha-L-fucosyltransferase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: TDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C55__45__PP__45__GLCNAC__45__MANNACA" stoichiometry="1"/>
      <speciesReference species="TDP__45__FUC4NAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
      <speciesReference species="C55__45__PP__45__GLCNAC__45__MANNACA__45__FUC4NAC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONATE__45__5__45__DEHYDROGENASE__45__RXN" name="Gluconate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1773 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative gluconate 5-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>SUBSYSTEM: L-idonate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.69</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__DEHYDROGLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__16__45__RXN" name="Serine/threonine specific protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Outer membrane protein yopM (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.16</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTP_TO_CMP_COF_RXN" name="CTP_TO_CMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1748_guaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional GMP synthase/glutamine amidotransferase protein//GMP-SYN-GLUT-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.2</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__384" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1258_ntpA ) or ( SG1362 ) or ( SG0511_mazG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dATP pyrophosphohydrolase ) or ( putative pyrophosphohydrolase ) or ( nucleoside triphosphate pyrophosphohydrolase//RXN0-1041 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8001" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1129_hisD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOATE__45__BETA__45__ALANINE__45__LIG__45__RXN" name="Pantoate--&amp;beta;-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0487_panC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pantothenate synthetase (PS) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme)//PANTOATE-BETA-ALANINE-LIG-RXN//Pantoate--beta-alanine ligase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FPPSYN__45__RXN" name="geranyltranstransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0657 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase )</html:p>
<html:p>SUBSYSTEM: geranylgeranyldiphosphate biosynthesis II (plastidic)</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SORB6PDEHYDROG__45__RXN" name="Sorbitol-6-phosphate 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sorbitol-6-phosphate 2-dehydrogenase (Glucitol-6- phosphate dehydrogenase) (Ketosephosphate reductase) (fragment)//Sorbitol-6-phosphate 2-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: sorbitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.140</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SORBITOL__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1122 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerate kinase I (fragment) ) or ( glycerate kinase II (fragment) ) or ( glycerate kinase I (fragment) ) or ( glycerate kinase I (fragment) )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDO__45__8PPHOSPHAT__45__RXN" name="3-deoxy-manno-octulosonate-8-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0203 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.45</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="KDO__45__8P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTOLDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1129_hisD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinol dehydrogenase//HISTALDEHYD-RXN )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R9__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase-isomerase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD_TO_NADH_COF_RXN" name="NAD_TO_NADH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__KINASE__45__RXN" name="shikimate-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2309_aroK ) or ( SG0634_aroL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Shikimate kinase 1 (SK 1)//SHIKIMATE-KINASE-RXN//Shikimate kinase ) or ( Shikimate kinase 2 (SK 2)//SHIKIMATE-KINASE-RXN//Shikimate kinase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.71</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROGBIOSYN__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2184_gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.94</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHENYLTHFCYCLOHYDRO__45__RXN" name="Methenyltetrahydrofolate cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0706_folD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN//Methenyltetrahydrofolate cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: reductive acetyl coenzyme A pathway</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__PPENTOMUT__45__RXN" name="Phosphopentomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0396_deoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphopentomutase (Phosphodeoxyribomutase)//D-PPENTOMUT-RXN//PPENTOMUT-RXN//Phosphopentomutase )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYLESTERASE__45__RXN" name="Carboxylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0956 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative esterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Carboxylic__45__esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DARABISOM__45__RXN" name="Arabinose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0181_fucI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-fucose isomerase )</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation II</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2PGADEHYDRAT__45__RXN" name="Phosphopyruvate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0513_eno )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Enolase (2-phosphoglycerate dehydratase) (2-phospho-D- glycerate hydro-lyase)//2PGADEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOKIN__45__RXN" name="Gluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2151_gntK ) or ( SG0980 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gluconate kinase 1//GLUCONOKIN-RXN ) or ( tyrosine kinase )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: L-idonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMKALT__45__RXN" name="T2-induced deoxynucleotide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2221_gmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Guanylate kinase (GMP kinase)//GUANYL-KIN-RXN//Guanylate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( SG1715 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase 2, thiamin-binding (fragment) ) or ( transketolase 1, thiamin-binding (fragment) ) or ( transketolase 1, thiamin-binding (fragment) ) or ( transketolase ) or ( transketolase 2, thiamin-binding (fragment) )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDPHOS__45__RXN" name="Histidinol-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1127 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( imidazole glycerol-phosphate dehydratase/histidinol phosphatase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.15</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__KIN__45__RXN" name="NAD(+) kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1799_ppnK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inorganic polyphosphate/ATP-NAD kinase )</html:p>
<html:p>SUBSYSTEM: NAD phosphorylation and dephosphorylation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.23</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Quinones__124___TO___124__Reduced__45__Quinones__124___COF_RXN" name="|Quinones|_TO_|Reduced-Quinones|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Reduced__45__Quinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__TYROSINE__45__PHOSPHATASE__45__RXN" name="Protein-tyrosine-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0979 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative tyrosine-phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.48</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8972" name="UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0444_murE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Lysine__45__or__45__DAP__124__" stoichiometry="1"/>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__UDP__45__N__45__acetylmuramoyl__45__Tripeptide__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERSYN__45__RXN" name="CDP-diacylglycerol--serine O-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1911_pssA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine synthase//PHOSPHASERSYN-RXN )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.8</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATE__45__1__45__EPIMERASE__45__RXN" name="Glucose-6 phosphate 1-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: sucrose degradation IV</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALGLDAPAALIG__45__RXN" name="UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0445_murF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase//UDP-NACMURALGLDAPAALIG-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C1" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8973" name="UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0445_murF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase//UDP-NACMURALGLDAPAALIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
      <speciesReference species="__124__UDP__45__N__45__acetylmuramoyl__45__Tripeptide__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__UDP__45__NAcMur__45__Peptides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__6__46__1__46__10__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0515 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 6-pyruvoyl tetrahydrobiopterin synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__ETCETERA__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__ETCETERA__45__DIHYDROXYPTERIDINE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8976" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0449_murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosaminyl transferase//NACGLCTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7695" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA_TO_CO__45__A_COF_RXN" name="MALONYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8975" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0446_mraY ) or ( SG2385 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phospho-N-acetylmuramoyl-pentapeptide-transferase (UDP- MurNAc-pentapeptide phosphotransferase)//PHOSNACMURPENTATRANS-RXN//Phospho-N-acetylmuramoyl-pentapeptide-transferase ) or ( undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: UNDECAPRENYL__45__P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C3" stoichiometry="1"/>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C4" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAPHTHOATE__45__SYN__45__RXN" name="naphthoate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SODGM3899 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Naphthoate synthase//Naphthoate synthase )</html:p>
<html:p>SUBSYSTEM: menaquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.36</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__SUCCINYLBENZOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="DIHYDROXYNAPHTHOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__88__45__RXN" name="Peptide deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2246_def )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peptide deformylase (PDF) (Polypeptide deformylase)//3.5.1.88-RXN//Peptide deformylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.88</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINESYN__45__RXN" name="Spermidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0479 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine synthase )</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__KIN__45__RXN" name="Glycerol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2172 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol kinase )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.30</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2361" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0357 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALA__45__D__45__GLU__45__MESOA2PM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URKI__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0973 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine kinase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UNDECAPRENYL__45__DIPHOSPHATASE__45__RXN" name="Undecaprenyl-diphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0257_uppP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Undecaprenyl-diphosphatase (Undecaprenyl pyrophosphate phosphatase) (Bacitracin resistance protein)//Undecaprenyl-diphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.27</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG2397 ) or ( SG2396_ilvM ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetolactate synthase III, large subunit (fragment) ) or ( acetolactate synthase 2 catalytic subunit ) or ( acetolactate synthase 2 regulatory subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN ) or ( acetolactate synthase III, large subunit (fragment) )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSAAMINOTRANS__45__RXN" name="Glutamate-1-semialdehyde 2,1-aminomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0500_hemL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT)//GSAAMINOTRANS-RXN//Glutamate-1-semialdehyde 2,1-aminomutase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTAMATE__45__1__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERKIN__45__RXN" name="Homoserine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0405 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoserine kinase )</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.39</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2391_ilvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ketol-acid reductoisomerase (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase)//ACETOLACTREDUCTOISOM-RXN//ACETOOHBUTREDUCTOISOM-RXN//Ketol-acid reductoisomerase )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLULOSE__45__REDUCTASE__45__RXN" name="D-xylulose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0610 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative xylitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PMPOXI__45__RXN" name="Pyridoxamine-phosphate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1447_pdxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyridoxamine 5&apos;-phosphate oxidase (PNP/PMP oxidase) (PNPOx)//PMPOXI-RXN//PNPOXI-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGTPTRIPHYDRO__45__RXN" name="Deoxyguanosinetriphosphate triphosphohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0504_dgt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyguanosinetriphosphate triphosphohydrolase//DGTPTRIPHYDRO-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.5.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYGUANOSINE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1397_trpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase subunit alpha//TRYPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: GAP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPMANACATRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2374 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative UDP-N-acetyl-D-mannosaminuronic acid transferase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__MANNACA" stoichiometry="1"/>
      <speciesReference species="GLCNAC__45__PP__45__LIPID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="C55__45__PP__45__GLCNAC__45__MANNACA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R343__45__RXN" name="Cob(II)yrinic acid a,c-diamide reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0862 ) or ( SG1948 ) or ( SG2404 ) or ( SG1994 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavodoxin FldA ) or ( flavodoxin ) or ( flavodoxin ) or ( flavodoxin FldB )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 1.16.8.1</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: FMN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__689" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__694" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICONUCADENYLYLTRAN__45__RXN" name="Nicotinate-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0800_nadD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinic acid mononucleotide adenyltransferase//NICONUCADENYLYLTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__57__45__RXN" name="aromatic-amino-acid transaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1006 ) or ( SG2131 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase ) or ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aromatic__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aromatic__45__Oxoacids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCISOM__45__RXN" name="L-fucose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0181_fucI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-fucose isomerase )</html:p>
<html:p>SUBSYSTEM: fucose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.25</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__FUCULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINE__45__6__45__P__45__DEAMIN__45__RXN" name="Glucosamine-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0858_nagB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine-6-phosphate deaminase )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OCTAPRENYL__45__4__45__OHBENZOATE__45__DECARBOX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0116_ubiD ) or ( SG1612 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (Polyprenyl p-hydroxybenzoate decarboxylase) ) or ( 3-octaprenyl-4-hydroxybenzoate carboxy-lyase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYLPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UTPHEXPURIDYLYLTRANS__45__RXN" name="UTP--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0896 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative galactose-1-phosphate uridylyltransferase )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8991" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0435 ) or ( SG0434_leuD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopropylmalate isomerase large subunit ) or ( isopropylmalate isomerase small subunit//3-ISOPROPYLMALISOM-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9451" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8992" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0362 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYRIBONUCSYN__45__RXN" name="Phosphoribosylamine--glycine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0142 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycineamide synthase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYSYN__45__RXN" name="phosphatidate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1937_cdsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diglyceride synthase//CDPDIGLYSYN-RXN )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.41</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__1__45__PHOSPHAT__45__RXN" name="Glucose-1-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative phosphatase precursor (fragment) )</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__D__45__Glucose__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFATE__45__ADENYLYLTRANS__45__RXN" name="Sulfate adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0522_cysN ) or ( SG0521 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfate adenylyltransferase subunit 1//SULFATE-ADENYLYLTRANS-RXN ) or ( sulfate adenylyltransferase subunit 2 )</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: sulfite oxidation III</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.4</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBONYL__45__REDUCTASE__45__NADPH__45__RXN" name="Carbonyl reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Short-chain dehydrogenase/reductase SDR (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.184</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LONG__45__CHAIN__45__KETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PPGPPSYN__45__RXN" name="Guanosine-3&apos;,5&apos;-bis(diphosphate) 3&apos;-pyrophosphohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2223 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional (p)ppGpp synthetase II/ guanosine-3&apos;,5&apos;-bis pyrophosphate 3&apos;-pyrophosphohydrolase )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.7.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE__45__5DP__45__3DP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__5__45__EPIMERASE__45__RXN" name="UDP-glucuronate 5&apos;-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1369 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative nucleotide sugar epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__223" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALISOM__45__RXN" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0435 ) or ( SG0434_leuD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopropylmalate isomerase large subunit ) or ( isopropylmalate isomerase small subunit//3-ISOPROPYLMALISOM-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9451" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCPDIESTER__45__RXN" name="Glycerophosphodiester phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerophosphodiester phosphodiesterase, cytosolic (fragment) )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.46</html:p>
<html:p>SIDE: __124__Alcohols__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycerophosphodiesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPNACETYLMURAMATEDEHYDROG__45__RXN" name="UDP-N-acetylmuramate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0124 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylenolpyruvoylglucosamine reductase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.158</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPMANNACADEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2382_wecC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetyl-D-mannosamine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__MANNACA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMHYDR__45__RXN" name="Fumarate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1462_fumC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarate hydratase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLCNACEPIM__45__RXN" name="UDP-N-acetylglucosamine 2-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2383 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine 2-epimerase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8998" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1938 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9453" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9452" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8997" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1938 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9454" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9453" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8999" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1938 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9452" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8994" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1938 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9457" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9456" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRIBFAICARPISOM__45__RXN" name="N-(5&apos;-phospho-D-ribosylformimino)-5-amino-1-(5&apos;&apos;-phosphoribosyl)-4- imidazole carboxamide isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1125_hisA ) or ( SG1124 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase)//PRIBFAICARPISOM-RXN ) or ( imidazole glycerol phosphate synthase subunit HisF )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8993" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1938 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9457" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8996" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1938 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9455" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9454" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ANTHRANSYN__45__RXN" name="Anthranilate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1401 ) or ( SG1402 ) or ( SG1400_trpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anthranilate synthase component II ) or ( anthranilate synthase component I TrpE ) or ( anthranilate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.27</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8995" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1938 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9456" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9455" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__LYASE__45__RXN" name="Cystathionine &amp;beta;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0280 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-lyase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.8</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4621" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1445_anmK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Anhydro-N-acetylmuramic acid kinase (AnhMurNAc kinase) )</html:p>
<html:p>SUBSYSTEM: 1,6-anhydro-N-acetylmuramic acid recycling</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__882" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1397_trpA ) or ( SG1398 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase subunit alpha//TRYPSYN-RXN ) or ( tryptophan synthase subunit beta )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCYSDESULF__45__RXN" name="D-cysteine desulfhydrase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0911 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-cysteine desulfhydrase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMPKI__45__RXN" name="Cytidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0992_cmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidylate kinase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1172_pgsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (Phosphatidylglycerophosphate synthase) (PGP synthase)//PHOSPHAGLYPSYN-RXN//CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.5</html:p>
<html:p>SIDE: GLYCEROL__45__3P</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__129__45__RXN" name="Peptidoglycan glycosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2311_mrcA ) or ( SG0494_mrcB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptidoglycan synthetase ) or ( penicillin-binding protein 1b )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.129</html:p>
<html:p>SIDE: UNDECAPRENYL__45__DIPHOSPHATE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7695" stoichiometry="1"/>
      <speciesReference species="__124__Peptidoglycans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="__124__Peptidoglycans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLPROLYL__45__ISOMERASE__45__RXN" name="Peptidylprolyl isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2303 ) or ( SG0675 ) or ( SG0670_tig ) or ( SG0704 ) or ( SG0426_surA ) or ( SG2293 ) or ( SG2291 ) or ( SG0349 ) or ( SG0416 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptidyl-prolyl cis-trans isomerase A (rotamase A) ) or ( peptidyl-prolyl cis-trans isomerase (rotamase D) ) or ( Trigger factor (TF) ) or ( peptidyl-prolyl cis-trans isomerase B (rotamase B) ) or ( Chaperone surA precursor (Peptidyl-prolyl cis-trans isomerase surA) (PPIase surA) (Rotamase surA)//PEPTIDYLPROLYL-ISOMERASE-RXN ) or ( FKBP-type peptidyl-prolyl cis-trans isomerase ) or ( FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FKBP-type peptidyl-prolyl cis-trans isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8625" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRS__45__RXN" name="phosphoribosylformylglycinamidine cyclo-ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1732_purM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase)//AIRS-RXN//Phosphoribosylformylglycinamidine cyclo-ligase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROPRIBTRANS__45__RXN" name="Orotate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2212_pyrE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( orotate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__REDUCT__45__RXN" name="Sulfite reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0517_cysI ) or ( SG0516_cysJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sulfite reductase [NADPH] hemoprotein beta-component (SIR-HP) (SIRHP)//SULFITE-REDUCT-RXN ) or ( Sulfite reductase [NADPH] flavoprotein alpha-component (SIR-FP)//SULFITE-REDUCT-RXN )</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_SUC__45__COA_COF_RXN" name="CO-A_TO_SUC-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PURIDYLTRANS__45__RXN" name="UTP--glucose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1367 ) or ( SG1113 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UTP--glucose-1-phosphate uridylyltransferase subunit GalU//UTP--glucose-1-phosphate uridylyltransferase ) or ( UTP-glucose-1-phosphate uridylyltransferase )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDLIPOXN__45__RXN" name="Dihydrolipoamide dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0469 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrolipoamide dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG2395 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYLPHENOL__45__HYDROX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0111_ubiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ubiquinone biosynthesis protein UbiB )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYLPHENOL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__884" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0417_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__882" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1760_ispG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Protein__45__Disulfides__124__</html:p>
<html:p>SIDE: __124__Protein__45__Dithiols__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase (fragment) )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.284</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="VALINE__45__PYRUVATE__45__AMINOTRANSFER__45__RXN" name="Valine--pyruvate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0009_avtA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( valine--pyruvate transaminase )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.66</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__58__45__RXN" name="Phenylalanine(histidine) aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1006 ) or ( SG2131 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase ) or ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.58</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOSEPHOSPHO__45__RXN" name="transport of fructose by PTS" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or ( SODGM5992_agaD ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused fructose-specific PTS enzymes: IIA component ; HPr component (fragment) ) or ( fused glucose-specific PTS enzymes: IIBcomponent ; IIC component (fragment) ) or ( fused maltose and glucose-specific PTS enzymes: IIB component -! IIC component (fragment) ) or ( fused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component ; IIC component (fragment) ) or ( N-acetylgalactosamine-specific enzyme IID component of PTS ) or ( fused glucose-specific PTS enzymes: IIBcomponent ; IIC component (fragment) ) or ( fused cellobiose/arbutin/salicin-specific PTS enzymes: IIB component ; IIC component (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU1P" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GART__45__RXN" name="Phosphoribosylglycinamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SG1272_purT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase 1 (fragment) ) or ( phosphoribosylglycinamide formyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.2</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAMDECARB__45__RXN" name="Adenosylmethionine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0478_speD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine decarboxylase proenzyme (AdoMetDC) (SamDC) [Contains: S-adenosylmethionine decarboxylase beta chain; S- adenosylmethionine decarboxylase alpha chain]//SAMDECARB-RXN )</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.50</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAPOXNPHOSPHN__45__RXN" name="Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1347 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyceraldehyde 3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2582" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1363 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( exonuclease III )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.21.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8533" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8532" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULPEPIM__45__RXN" name="L-ribulose-phosphate 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG1415_araD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-ribulose-5-phosphate 4-epimerase )</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__RIBULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD_TO_FADH2_COF_RXN" name="FAD_TO_FADH2_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FADH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__3__46__1__46__17__45__RXN" name="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-keto 4-deoxyuronate isomerase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__37" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__343" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.22</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMUR__45__ALA__45__LIG__45__RXN" name="UDP-N-acetylmuramate--alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG0450_murC ) or ( SG0357 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramate--L-alanine ligase (UDP-N- acetylmuramoyl-L-alanine synthetase)//UDP-NACMUR-ALA-LIG-RXN//UDP-N-acetylmuramate--L-alanine ligase ) or ( UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__ACETYLMURAMOYL__45__ALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
