<?xml version="1.0"  encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="RHILO101_metabolic_network_metabolic_network" name="Mesorhizobium loti">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
  <species id="CPD__45__7229" name="1-(&amp;beta;-D-ribofuranosyl)-1,4-dihydronicotinamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__107" name="6-hydroxypseudooxynicotine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUCURONATE" name="glucuronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" name="hydroxymethylpyrimidine phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__106" name="(S)-4-Hydroxymandelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__105" name="(R)-4-Hydroxymandelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__313" name="1,3-diaminopropane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Monophosphates__124__" name="a ribonucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7221" name="3-cis-dodecenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__XYLULOSE" name="L-xylulose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7222" name="2-trans-dodecenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DIHYDROXY__45__PHENYLALANINE" name="L-dopa" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Phospholipid__45__Cyclopropane__45__Fatty__45__Acids__124__" name="a phospholipid cyclopropane fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7224" name="N-acetyl-L-citrulline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Amino__45__Acids__124__" name="a D-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEHYDRO__45__DEOXY__45__GALACTONATE__45__PHOSPHATE" name="2-dehydro-3-deoxy-D-galactonate-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GAMMA__45__GLUTAMYLCYSTEINE" name="L-&amp;gamma;-glutamylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP" name="GDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1086" name="5-amino-6-(5&apos;-phosphoribitylamino)uracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="APS" name="adenosine 5&apos;-phosphosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ISOPENICILLIN__45__N" name="isopenicillin N" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" name="an L-1-phosphatidyl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SEDOHEPTULOSE__45__7__45__P" name="D-sedoheptulose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__110" name="salicylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROFOLATE" name="7,8-dihydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acceptor__124__" name="an oxidized electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ILE" name="L-isoleucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__N__45__Carbamoyl__45__D__45__Amino__45__Acids__124__" name="an N-carbamoyl D-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARG" name="L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__302" name="D-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GALACTURONATE" name="galacturonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__CHLORO__45__24__45__DINITROBENZENE" name="1-chloro-2,4-dinitrobenzene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BISOHMYR__45__GLC" name="lipid A disaccharide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__882" name="1,6-anhMurNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__881" name="MurNAc-6-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMP" name="inosine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TARTRONATE__45__S__45__ALD" name="tartronate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6972" name="4-(2&apos;-carboxyphenyl)-4-oxobutyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__METHYL__45__1__45__246__45__TRIHYDROXYPHENYLBUTAN" name="phlorisovalerophenone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATRAZINE" name="atrazine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__ETCETERA__45__GLUCOSAMINYLDIPHOSPHOUND" name="prenyl-P-P-GlcNAc-ManNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ" name="2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__335" name="(R)-3-hydroxybutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__ARYL__45__2__45__METHYLMALONATE" name="2-aryl-2-methylmalonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" name="4-amino-4-deoxychorismate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NUC__45__5__45__PHOSPHATE" name="a nucleoside-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__D__45__GLUCOSE" name="GDP-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYDROXYPROPANAL" name="3-hydroxypropionaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOAMIDE" name="lipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" name="a protein L-&amp;beta;-isoaspartate &amp;alpha;-methyl ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" name="formyl-L-methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ASN" name="L-asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ASPARTATE" name="L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="E__45__37__45__DIMETHYLOCTA__45__16__45__DIEN__45__38__45__DIOL" name="(E)-3,7-dimethylocta-1,6-dien-3,8-diol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALONATE__45__S__45__ALD" name="malonate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__8" name="ubiquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BENZOATE" name="benzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__9" name="ubiquinone-9" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACRYLATE" name="acrylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Donor__45__H2__124__" name="a reduced electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CYSTATHIONINE" name="cystathionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1063" name="5-methylthioribulose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" name="6,7-dimethyl-8-(1-D-ribityl)lumazine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL" name="pyridoxal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__329" name="L-xylo-hexulonolactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" name="D-myo-inositol (3)-monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TREHALOSE__45__6P" name="trehalose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYADENOSINE" name="deoxyadenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7408" name="phytofluene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" name="2-octaprenyl-6-hydroxyphenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATP" name="ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" name="UDP-N-acetyl-D-galactosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Long__45__Chain__45__Polyphosphate__124__" name="long chain polyphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MG__45__PROTOPORPHYRIN" name="Mg-protoporphyrin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6141" name="N-methyl-&amp;beta;-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSE" name="&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6142" name="N,N-dimethyl-&amp;beta;-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7000" name="isobutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOLLATE" name="glycolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH__45__P__45__OR__45__NOP" name="NAD(P)H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="T2__45__DECENOYL__45__COA" name="trans-&amp;Delta;2-decenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" name="dTDP-4-dehydro-6-deoxy-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__121" name="(R)-mandelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__122" name="(S)-mandelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDPDIACYLGLYCEROL" name="a CDP-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXYADIPYL__45__COA" name="3-hydroxyadipyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__LACTATE" name="D-lactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Monophosphates__124__" name="a nucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8199" name="a mismatched DNA base pair" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4822" name="kanamycin B" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__CHLOROETHANOL" name="2-chloroethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8192" name="demethylsuberosin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" name="a 2,3,4-saturated fatty acyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__352" name="estradiol-17&amp;beta;" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__PROPIONYL__45__COA" name="3-hydroxypropionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CANAVANINE" name="canavanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Methanofurans__124__" name="methanofuran" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__1__45__ARSENATE" name="ribose-1-arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROKAEMPFEROL__45__CMPD" name="dihydrokaempferol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__3__45__HYDROXYACYL__45__COA" name="a (3S)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARSENATE" name="arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TYR" name="L-tyrosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETO__45__6__45__AMINO__45__CAPROATE" name="2-keto-6-aminocaproate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE" name="N-acetyl-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" name="3-deoxy-D-arabino-heptulosonate-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THREO__45__DS__45__ISO__45__CITRATE" name="D-isocitrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8186" name="umbelliferone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LYS" name="L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENYLOSUCC" name="adenylo-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8180" name="DNA with lesion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__342" name="5&amp;alpha;-Androstane-3,17-dione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__AP__45__Site__45__Created__124__" name="an AP(apurinic or apyrimidinic) site created by glycosylic bond cleavage" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUMP" name="dUMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" name="4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOPORPHYRIN_IX" name="protoporphyrin IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" name="an unsulfurated sulfur acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KDO__45__8P" name="3-deoxy-D-manno-octulosonate 8-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALLO__45__THR" name="allothreonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__371" name="1-octanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UROPORPHYRINOGEN__45__III" name="uroporphyrinogen-III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C4" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl- D-alanyl-D-alanine-diphosphoundecaprenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C3" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C6" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OH__45__MYRISTOYL" name="UDP-2,3-bis(3-hydroxymyristoyl)glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C5" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROPIONYL__45__P" name="propionyl-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCERATE" name="D-glycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__377" name="2-dehydro-D-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7035" name="2-phenylethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIETHYLTHIOPHOSPHATE" name="diethylthiophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__375" name="4-pyridoxolactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7037" name="methionol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7036" name="3-methylthiopropanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__MERCAPTO__45__PYRUVATE" name="3-mercaptopyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7031" name="3-methylbutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7032" name="isoamyl alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUTACONYL__45__COA" name="glutaconyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7033" name="2-methylbutanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2K__45__ADIPATE" name="&amp;alpha;-ketoadipate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Phospholipid__45__Olefinic__45__Fatty__45__Acids__124__" name="a phospholipid olefinic fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__369" name="L-iditol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__DEHYDROGLUCONATE" name="5-ketogluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C1" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate- D-alanyl-D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANOSINE__45__5DP__45__3DP" name="guanosine 5&apos;-diphosphate,3&apos;-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__365" name="2-keto-myo-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BISOHMYR__45__GLUCOSAMINYL__45__1P" name="2,3-bis(3-hydroxymyristoyl)-&amp;beta;-D-glucosaminyl 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" name="1-(o-carboxyphenylamino)-1&apos;-deoxyribulose-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRANS__45__POLYISOPRENYL__45__PP" name="a trans-polyisoprenyln-PP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Amineated__45__Amine__45__Donors__124__" name="an amineated amine donor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXY__45__ACETONE__45__PHOSPHATE" name="dihydroxy-acetone phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYDROXYMETHYLBILANE" name="hydroxymethylbilane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Triphosphates__124__" name="a nucleoside triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__358" name="D-lactaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC" name="&amp;beta;-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OCTAPRENYL__45__METHYL__45__OH__45__METHOXY__45__BENZQ" name="3-demethylubiquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TARTRATE" name="L-tartrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__OXOADIPATE__45__ENOL__45__LACTONE" name="&amp;beta;-ketoadipate-enol-lactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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<notes>
<html:p>GENE_ASSOCIATION: ( mll6664 ) or ( mll9204 ) or ( mlr8297 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to 2-amino-3-ketobutyrate CoA ligase ) or ( 2-amino-3-ketobutyrate coenzyme A ligase ) or ( 2-amino-3-ketobutyrate coenzyme A ligase )</html:p>
<html:p>SUBSYSTEM: threonine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.29</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
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      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
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    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
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  <reaction id="GST__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0559 ) or ( mlr0981 ) or ( mlr1135 ) or ( mlr2052 ) or ( mlr8180 ) or ( mll2536 ) or ( mlr2042 ) or ( mll3731 ) or ( mll4939 ) or ( mlr1410 ) or ( mll4614 ) or ( mlr7058 ) or ( mll3775 ) or ( mlr4635 ) or ( mlr4954 ) or ( mll0034 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( putative glutathione S-transferase YghU ) or ( probable glutathione S-transferase ) or ( probable glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione-S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( similar to glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase III )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
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      <speciesReference species="_1__45__CHLORO__45__24__45__DINITROBENZENE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
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    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="S__45__24__45__DINITROPHENYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1405_ilvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ketol-acid reductoisomerase (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase)//Ketol-acid reductoisomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDHDEHYDROG__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7045 ) or ( mll2867 ) or ( mll1015 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEXENEDIOATE__45__AUTOTRANSFORMATION__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__185" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R547__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__868" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__869" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRAISOM__45__RXN" name="Phosphoribosylanthranilate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5070_trpF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-(5&apos;-phosphoribosyl)anthranilate isomerase (PRAI) )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.24</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENETHFDEHYDROG__45__NADP__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6508_folD1 ) or ( mll6921_folD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional protein folD 1 [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//Methenyltetrahydrofolate cyclohydrolase ) or ( Bifunctional protein folD 2 [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//Methenyltetrahydrofolate cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: reductive acetyl coenzyme A pathway</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLALANINE__45__DECARBOXYLASE__45__RXN" name="Phenylalanine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0712 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid decarboxylase )</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.53</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLETHYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__NH3__45__RXN" name="GMP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6950_guaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase)//GMP-SYN-GLUT-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOSINE__45__DEHYDROGENASE__45__RXN" name="Sarcosine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1213 ) or ( mlr1283 ) or ( mll1258 ) or ( mll5369 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sarcosine dehydrogenase ) or ( sarcosine dehydrogenase ) or ( sarcosine dehydrogenase ) or ( sarcosine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: creatinine degradation II</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__56__45__RXN" name="Lipopolysaccharide N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6753 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable sugar transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.56</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Lipopolysaccharides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__ETCETERA__45__LIPOPOLYSACCHARIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSLIG__45__RXN" name="Phosphopantothenate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3167 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MACROCIN__45__O__45__METHYLTRANSFERASE__45__RXN" name="Macrocin O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2453 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( macrocin-O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.101</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MACROCIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYLOSIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTRACE__45__RXN" name="Glutamate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0039_murI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutamate racemase//GLUTRACE-RXN//Glutamate racemase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R561__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: nylon-6 oligomer degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__883" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__884" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RHAMNULOKIN__45__RXN" name="Rhamnulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5701 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to L-fuculokinase )</html:p>
<html:p>SUBSYSTEM: rhamnose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RHAMNULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RHAMNULOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__761" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9595 ) or ( msr9761 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate synthase ) or ( similar to trehalose-6-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__969" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4732 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycolate oxidase, (S)-2-hydroxy-acid oxidase , peroxisomal//(S)-2-hydroxy-acid oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__50__45__RXN" name="3-&amp;alpha;-hydroxysteroid dehydrogenase (B-specific)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7199 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-alpha-hydroxysteroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.50</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ANDROSTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__342" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATE__45__SYNTHASE__45__RXN" name="Chorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7461 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chorismate synthase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.5</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLHOMOSER__45__CYS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8465 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-acetylhomoserine aminocarboxypropyltransferase )</html:p>
<html:p>SUBSYSTEM: homocysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.49</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7006 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribulose bisphosphate carboxylase, large subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__RIBULOSE__45__15__45__P2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
      <speciesReference species="CPD__45__67" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HIPPURATE__45__HYDROLASE__45__RXN" name="Hippurate hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2296 ) or ( mlr7940 ) or ( mlr9207 ) or ( mlr3583 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable hydrolase ) or ( hippurate hydrolase ) or ( probable hydrolase ) or ( hippurate hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.32</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__425" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROCANATE__45__HYDRATASE__45__RXN" name="Urocanate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8323_hutU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Urocanate hydratase (Urocanase) (Imidazolonepropionate hydrolase)//Urocanate hydratase )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.49</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROCANATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__3__45__PHOSPHATE__45__DEHYDROGENASE__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0710_glpD ) or ( mlr4225_gpsA ) or ( mlr7270 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase//GLYC3PDEHYDROG-RXN ) or ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN ) or ( glycerol-3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCISOM__45__RXN" name="Xylose isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4975 ) or ( mlr5036_xylA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( contains weak similarity to Xylose Isomerase (E.C.5.3.1.5) ) or ( Xylose isomerase//XYLISOM-RXN//Xylose isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSE6PSYN__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0691 ) or ( mlr9595 ) or ( RHILO0109 ) or ( msr9761 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate phosphatase ) or ( trehalose-6-phosphate synthase ) or ( putative Alpha,alpha-trehalose-phosphate synthase (UDP-forming)//Alpha,alpha-trehalose-phosphate synthase (UDP-forming) ) or ( similar to trehalose-6-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.15</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTEROATESYNTH__45__RXN" name="Dihydropteroate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0788 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxypteroate synthase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.15</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__AMINOTRANSFERASE__45__RXN" name="Tryptophan aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0405 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.27</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXY__45__2__45__KETOPIMELATE__45__LYSIS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0073 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.-</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__804" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CPM__45__KDOSYNTH__45__RXN" name="3-deoxy-manno-octulosonate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5497 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-manno-octulosonate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.38</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="KDO" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BILIRUBIN__45__OXIDASE__45__RXN" name="Bilirubin oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3586 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative periplasmic oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BILIRUBIN" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIVERDINE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYPYPHOSPHA__45__RXN" name="CDP-diacylglycerol pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILO4151 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative CDP-diacylglycerol phosphotidylhydrolase (EC 3.6.1.26) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.26</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLN_TO_GLT_COF_RXN" name="GLN_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAICARSYN__45__RXN" name="Phosphoribosylaminoimidazole-succinocarboxamide synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2603_purC2 ) or ( mll0069_purC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2 (SAICAR synthetase 2) ) or ( Phosphoribosylaminoimidazole-succinocarboxamide synthase 1 (SAICAR synthetase 1) )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCDIAMINOPIMDESUCC__45__RXN" name="Succinyl-diaminopimelate desuccinylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4849 ) or ( mlr1185 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl-diaminopimelate desuccinylase ) or ( succinyl-diaminopimelate desuccinylase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.18</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__SUCCINYLLL__45__2__45__6__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATPPHOSPHORIBOSYLTRANS__45__RXN" name="ATP phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6929_hisZ ) or ( mlr6931_hisG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP phosphoribosyltransferase regulatory subunit ) or ( ATP phosphoribosyltransferase (ATP-PRTase) (ATP-PRT)//ATPPHOSPHORIBOSYLTRANS-RXN//ATP phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.17</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP_TO_GDP__45__MANNOSE_COF_RXN" name="GDP_TO_GDP-MANNOSE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__HEXAPRENYLTRANSTRANSFERASE__45__RXN" name="trans-hexaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7426 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl-diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.30</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R314__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7070 ) or ( mll3370 ) or ( mlr9017 ) or ( mlr2310 ) or ( mlr5350 ) or ( mlr2975 ) or ( mlr3187 ) or ( mlr0229 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidase ) or ( amidase ) or ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( amidase ) or ( probable amidase ) or ( amidase ) or ( amidase ) or ( amidase )</html:p>
<html:p>SUBSYSTEM: aldoxime degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AGMATIN__45__RXN" name="Agmatinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4895 ) or ( mll8453 ) or ( mll0412 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( agmatinase ) or ( agmatinase ) or ( probable agmatinase )</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine degradation III (arginine decarboxylase/agmatinase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AGMATHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__271__45__RXN" name="GDP-L-fucose synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8749 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-L-fucose synthetase(Nodulation protein NolK) )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.271</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTODEXGLUCOSID__45__RXN" name="&amp;alpha;-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7593 ) or ( mll5109 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycosyl hydrolase ) or ( alpha-glucosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHIONINE__45__GAMMA__45__LYASE__45__RXN" name="Methionine &amp;gamma;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1618 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methionine gamma-lyase )</html:p>
<html:p>SUBSYSTEM: methionine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.11</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__7671</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__7671" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__PENTAPRENYLTRANSFERASE__45__RXN" name="Trans-pentaprenyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7426 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl-diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.33</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDRODIPICSYN__45__RXN" name="dihydrodipicolinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7746_dapA ) or ( mll6811 ) or ( mll3981 ) or ( mll6376 ) or ( mlr6292 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydrodipicolinate synthase (DHDPS)//DIHYDRODIPICSYN-RXN//Dihydrodipicolinate synthase ) or ( dihydroxydipicolinate synthase ) or ( dihydrodipicolinate synthase ) or ( dihydrodipicolinate synthetase ) or ( dihydrodipicolinate synthetase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.52</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__65__45__RXN" name="Salicylaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7197 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.65</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SALICYLALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__110" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RR__45__BUTANEDIOL__45__DEHYDROGENASE__45__RXN" name="(R,R)-butanediol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5168 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-butanediol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: butanediol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTANEDIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCOSE_TO_UDP_COF_RXN" name="UDP-GLUCOSE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5711 ) or ( mll6984 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamyltranspeptidase ) or ( gamma-glutamyltranspeptidase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
      <speciesReference species="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__1__45__DEHYDROGENASE__45__RXN" name="Glucose 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3115 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( short chain dehydrogenase )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.47</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4157" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0405 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.58</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG6PDEACET__45__RXN" name="N-acetylglucosamine-6-phosphate deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4766 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine-6-phosphate deacetylase )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine , N-acetylmannosamine and N-acetylneuraminic acid dissimilation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__GLU__45__AMINOTRANSFORASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6714 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine-oxo-acid transaminase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSNACMURPENTATRANS__45__RXN" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1558_mraY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phospho-N-acetylmuramoyl-pentapeptide-transferase (UDP- MurNAc-pentapeptide phosphotransferase)//PHOSNACMURPENTATRANS-RXN//Phospho-N-acetylmuramoyl-pentapeptide-transferase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: UNDECAPRENYL__45__P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
      <speciesReference species="C1" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C5" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMPCYCLOHYDROLASE__45__RXN" name="IMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4101_purH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase); IMP cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]//AICARTRANSFORM-RXN//IMPCYCLOHYDROLASE-RXN//Phosphoribosylaminoimidazolecarboxamide formyltransferase//IMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3781" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0809 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malic enzyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.39</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7793" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5650 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceramide glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.80</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Glucosyl__45__Ceramides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPDECARBOX__45__RXN" name="Aspartate 1-decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9093_panD2 ) or ( mll5826_panD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aspartate 1-decarboxylase 2 precursor (Aspartate alpha- decarboxylase 2) [Contains: Aspartate 1-decarboxylase beta chain; Aspartate 1-decarboxylase alpha chain]//Aspartate 1-decarboxylase ) or ( Aspartate 1-decarboxylase 1 precursor (Aspartate alpha- decarboxylase 1) [Contains: Aspartate 1-decarboxylase beta chain; Aspartate 1-decarboxylase alpha chain]//Aspartate 1-decarboxylase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.11</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPXPRIBOSYLTRAN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0141_gpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Xanthine phosphoribosyltransferase (Xanthine-guanine phosphoribosyltransferase) (XGPRT)//XANPRIBOSYLTRAN-RXN//Xanthine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__99__46__4__45__RXN" name="1-aminocyclopropane-1-carboxylate deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5932_acdS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-aminocyclopropane-1-carboxylate deaminase (ACC deaminase) (ACCD)//1-aminocyclopropane-1-carboxylate deaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__68" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HALOACETATE__45__DEHALOGENASE__45__RXN" name="Haloacetate dehalogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1864 ) or ( mlr1789 ) or ( mlr9622 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable hydrolase ) or ( probable epoxide hydrolase ) or ( hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Haloacetates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Halides__124__" stoichiometry="1"/>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNP__45__RXN" name="Purine-nucleoside phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0765 ) or ( mlr3159 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase ) or ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENMETSYN__45__RXN" name="Methionine adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6115_metK ) or (  ) or ( mlr5545 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine synthetase (Methionine adenosyltransferase) (AdoMet synthetase) (MAT)//S-ADENMETSYN-RXN//Methionine adenosyltransferase ) or ( S-adenosylmethionine synthetase (EC 2.5.1.6) (Methionine adenosyltransferase) (AdoMet synthetase) (MAT) (fragment)//Methionine adenosyltransferase ) or ( S-adenosylmethionine synthetase )</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANIDINOBUTANAMIDE__45__NH3__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7070 ) or ( mll3370 ) or ( mlr9017 ) or ( mlr2310 ) or ( mlr5350 ) or ( mlr2975 ) or ( mlr3187 ) or ( mlr0229 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidase ) or ( amidase ) or ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( amidase ) or ( probable amidase ) or ( amidase ) or ( amidase ) or ( amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__GUANIDO__45__BUTYRAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__592" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R22__45__RXN" name="Butyryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5624 ) or ( mll5430 ) or ( mlr7452 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( probable acyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__DEHYDROPANTOATE__45__REDUCT__45__RXN" name="2-dehydropantoate 2-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6982 ) or ( mll4847 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative 2-dehydropantoate 2-reductase (Ketopantoate reductase) (KPA reductase) (KPR)//2-dehydropantoate 2-reductase ) or ( 2-dehydropantoate 2-reductase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.169</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOX__45__RXN" name="Sarcosine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3111 ) or ( msl6239 ) or ( mlr8469 ) or ( mll7303 ) or ( mlr1273 ) or ( mll6240 ) or ( mll3108 ) or ( mll7304 ) or ( mlr1276 ) or ( mll6238 ) or ( mlr7042 ) or ( msr1274 ) or ( msl3109 ) or ( mll7306 ) or ( mll7022 ) or ( mlr1275 ) or ( msl7305 ) or ( mll5230 ) or ( msl5231 ) or ( mll5232 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sarcosine oxidase beta subunit ) or ( sarcosine oxidase delta subunit ) or ( sarcosine oxidase ) or ( similar to sarcosine oxidase gamma subunit ) or ( sarcosine oxidase beta subunit ) or ( sarcosine oxidase beta subunit ) or ( sarcosine oxidase alpha subunit ) or ( sarcosine oxidase alpha subunit ) or ( sarcosine oxidase gamma subunit ) or ( sarcosine oxidase alpha subunit ) or ( probable oxidoreductase ) or ( sarcosine oxidase delta subunit ) or ( sarcosine oxidase delta subunit ) or ( sarcosine oxidase beta subunit ) or ( sarcosine oxidase, subunit beta ) or ( sarcosine oxidase alpha subunit ) or ( sarcosine oxidase delta subunit ) or ( sarcosine oxidase alpha subunit ) or ( sarcosine oxidase delta subunit ) or ( sarcosine oxidase beta subunit )</html:p>
<html:p>SUBSYSTEM: creatinine degradation II</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNITOL__45__2__45__DEHYDROGENASE__45__RXN" name="Mannitol 2-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4920 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.67</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDEHYDE__45__OXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1015 ) or ( mll2867 ) or ( mll7045 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__358" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADOMET__45__DMK__45__METHYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3165_ubiE ) or ( mll6702 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ubiquinone/menaquinone biosynthesis methyltransferase ubiE ) or ( similar to menaquinone biosynthesis methyltransferase )</html:p>
<html:p>SUBSYSTEM: menaquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEMETHYLMENAQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VITAMIN_K_2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MHPELY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5426 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-2-oxovalerate aldolase )</html:p>
<html:p>SUBSYSTEM: 2-oxopentenoate degradation</html:p>
<html:p>SUBSYSTEM: catechol degradation II (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXY__45__2__45__KETOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__II__45__RXN" name="GTP cyclohydrolase II" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7463 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP cyclohydrolase II )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.25</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1160 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7784" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1975 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable cinnamoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.219</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7087" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7088" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1160 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSOPHOSPHOLIPASE__45__RXN" name="Lysophospholipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3034 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysophospholipase L2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__GLYCERO__45__PHOSPHORYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CINNAMOYL__45__COA__45__REDUCTASE__45__RXN" name="Cinnamoyl-CoA reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1975 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable cinnamoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.44</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CINNAMALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CINNAMOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHACYL__45__COA__45__DEHYDROG__45__RXN" name="3-hydroxyacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5041 ) or ( mlr2803 ) or ( mlr5629 ) or ( mll1034 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydrogenase ) or ( 3-hydroxyacyl-CoA dehydrogenase type II//3-hydroxyacyl-CoA dehydrogenase ) or ( probable 3-hydroxyacyl-CoA dehydrogenase ) or ( 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__1__45__RXN" name="&amp;gamma;-butyrobetaine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1440 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Probable gamma-butyrobetaine dioxygenase (Gamma- butyrobetaine,2-oxoglutarate dioxygenase) (Gamma-butyrobetaine hydroxylase) (Gamma-BBH) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.1</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAMMA__45__BUTYROBETAINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="EXOPOLYPHOSPHATASE__45__RXN" name="Exopolyphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8346 ) or ( mlr8162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( exopolyphosphatase ) or ( exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__262__45__RXN" name="4-hydroxythreonine-4-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7861_pdxA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxythreonine-4-phosphate dehydrogenase (4- (phosphohydroxy)-L-threonine dehydrogenase)//1.1.1.262-RXN//4-hydroxythreonine-4-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.262</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOSINE__45__NUCLEOSIDASE__45__RXN" name="Inosine nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2009 ) or ( mll3190 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine-uridine preferring nucleoside hydrolase ) or ( nucleoside hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PDXJ__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1418_pdxJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyridoxine 5&apos;-phosphate synthase (PNP synthase)//PDXJ-RXN//Pyridoxine 5&apos;-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.6.99.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="_1__45__AMINO__45__PROPAN__45__2__45__ONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__69__45__RXN" name="Protein-N(PI)-phosphohistidine-sugar phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3194 ) or ( mll3613 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphotransferase system enzyme II ) or ( phosphotransferase system enzyme II, BC COMPONENT )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sugar__124__" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
      <speciesReference species="__124__Sugar__45__Phosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" name="L-ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6633 ) or ( mlr4627 ) or ( mll6408 ) or ( mll5815 ) or ( mlr6390 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( coproporphyrinogen III oxidase ) or ( coproporphyrinogen III oxidase ) or ( coproporphyrinogen III oxidase ) or ( coproporphyrinogen III oxidase ) or ( coproporphyrinogen III oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.22</html:p>
<html:p>SIDE: CH33ADO</html:p>
<html:p>SIDE: MET</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVIN__45__SYN__45__RXN" name="Riboflavin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8407 ) or ( mll7281_ribH1 ) or ( mlr8409_ribH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( riboflavin synthase subunit alpha ) or ( 6,7-dimethyl-8-ribityllumazine synthase 1 (DMRL synthase 1) (Lumazine synthase 1) (Riboflavin synthase 1 beta chain)//Riboflavin synthase ) or ( 6,7-dimethyl-8-ribityllumazine synthase 2 (DMRL synthase 2) (Lumazine synthase 2) (Riboflavin synthase 2 beta chain)//Riboflavin synthase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP_TO_UTP_COF_RXN" name="UDP_TO_UTP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R11__45__RXN" name="Acetate CoA-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4183 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetate CoA-transferase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRIC_ACID" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_THF_COF_RXN" name="METHYLENE-THF_TO_THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5076 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthase (folC) )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__1__46__11__45__RXN" name="Phenylalanine racemase (ATP-hydrolysing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1968 ) or ( mll6752 ) or ( mll9722 ) or ( mll6746 ) or ( mlr9052 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptide synthetase ) or ( similar to CDA peptide synthetase III ) or ( peptide synthetase homolog ) or ( similar to pristinamycin I synthase 3 ) or ( peptide synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.11</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__216" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__50__45__RXN" name="Glutamine--scyllo-inosose aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7579 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.50</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
      <speciesReference species="CPD__45__365" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__GLUTARAMATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__1105" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IGPSYN__45__RXN" name="indole-3-glycerol-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0615_trpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Indole-3-glycerol phosphate synthase (IGPS) )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.48</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Ubiquinones__124___TO___124__Ubiquinols__124___COF_RXN" name="|Ubiquinones|_TO_|Ubiquinols|_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Ubiquinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ubiquinols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE_TO_UDP_COF_RXN" name="UDP-GLUCURONATE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__24__45__RXN" name="Phosphatidylcholine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0506_pcs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphatidylcholine synthase (CDP-diglyceride-choline O- phosphatidyltransferase) (PC synthase)//Phosphatidylcholine synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.24</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DALADEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9201_dadA3 ) or ( mll6285 ) or ( mlr5698_dadA2 ) or ( mll3992_dadA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-amino acid dehydrogenase 3 small subunit ) or ( D-amino acid dehydrogenase, small subunit ) or ( D-amino acid dehydrogenase 2 small subunit ) or ( D-amino acid dehydrogenase 1 small subunit )</html:p>
<html:p>SUBSYSTEM: alanine degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOCARBOLIG__45__RXN" name="Tartronate-semialdehyde synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0251 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxylate carboligase )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation (E. coli)</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.47</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_DIHYDROFOLATE_COF_RXN" name="METHYLENE-THF_TO_DIHYDROFOLATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UGD__45__RXN" name="UDP-glucose 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9719 ) or ( mlr5265 ) or ( mlr3262 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose dehydrogenase homolog ) or ( UDP-glucose dehydrogenase ) or ( nucleotide-sugar dehydrogenase (UDP-glucose/GDP-mannose dehydrogenase) )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-D-xylose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERCAPYSTRANS__45__RXN" name="3-mercaptopyruvate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0355 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiosulfate sulfurtransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCN" stoichiometry="1"/>
      <speciesReference species="_3__45__MERCAPTO__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HSCN" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYL__45__ALCOHOL__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Aryl-alcohol dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8386 ) or ( mlr0100 ) or ( mlr6441 ) or ( mll0645 ) or ( mlr4079 ) or ( mlr4087 ) or ( mll1952 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxido-reductase, and dehydratase mocA ) or ( oxidoreductase ) or ( similar to oxidoreductase ) or ( probable oxidoreductase ) or ( oxidoreductase ) or ( oxidoreductase, mocA ) or ( norsolorinic acid reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.91</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__Aldehyde__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4113" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3070 ) or ( mll5720 ) or ( mlr1913 ) or ( mlr1136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase) ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDRPHENYLAC__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__4151" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROLINE__45__MULTI" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4009_proA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gamma-glutamyl phosphate reductase (GPR) (Glutamate-5- semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase)//GLUTSEMIALDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7774" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4301_kgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-ketoglutarate decarboxylase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.71</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTAMINOTRANS__45__RXN" name="Histidinol-phosphate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5786_hisC3 ) or ( mll3536_hisC2 ) or ( mll7737 ) or ( mll7105_hisC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Histidinol-phosphate aminotransferase 3 (Imidazole acetol-phosphate transaminase 3) ) or ( Histidinol-phosphate aminotransferase 2 (Imidazole acetol-phosphate transaminase 2) ) or ( histidinol-phosphate aminotransferase ) or ( Histidinol-phosphate aminotransferase 1 (Imidazole acetol-phosphate transaminase 1) )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.9</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALGLDAPLIG__45__RXN" name="UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1560_murE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (UDP-N-acetylmuramyl-tripeptide synthetase) (Meso- diaminopimelate-adding enzyme) (UDP-MurNAc-tripeptide synthetase)//UDP-NACMURALGLDAPLIG-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4335 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitate hydratase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYXK__45__RXN" name="L-xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7268 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylulose kinase )</html:p>
<html:p>SUBSYSTEM: L-lyxose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.53</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__XYLULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDYLATE__45__SYNTHASE__45__RXN" name="Pseudouridylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0334 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribosomal large subunit pseudouridine synthase C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.70</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHOSINEPHOSPHORY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0765 ) or ( mlr3159 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase ) or ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__DELTA__45__ISOM__45__RXN" name="Dodecenoyl-CoA &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable enoyl-CoA hydratase/isomerase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__DELTA3__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SALICYLATE__45__1__45__MONOOXYGENASE__45__RXN" name="Salicylate 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8158 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( salicylate hydroxylase )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__110" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCUROISOM__45__RXN" name="Glucuronate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4056_uxaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Uronate isomerase (Glucuronate isomerase) (Uronic isomerase)//GALACTUROISOM-RXN//GLUCUROISOM-RXN//Glucuronate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4767 ) or ( mlr6774 ) or ( mll0833_glmS ) or ( mlr6386 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine-fructose-6-phosphate aminotransferase ) or ( D-fructose-6-phosphate amidotransferase ) or ( Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (Hexosephosphate aminotransferase) (D-fructose-6- phosphate amidotransferase) (GFAT) (L-glutamine-D-fructose-6-phosphate amidotransferase) (Glucosamine-6-phosphate synthase)//L-GLN-FRUCT-6-P-AMINOTRANS-RXN ) or ( D-fructose-6-phosphate amidotransferase )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.16</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__HYDRAT__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3048 ) or ( mlr8392 ) or ( mll5431 ) or ( mlr7453 ) or ( mlr8461 ) or ( mll1009 ) or ( mlr1841 ) or ( mlr6976 ) or ( mll6015 ) or ( mll6870 ) or ( mlr5044 ) or ( mlr5639 ) or ( mlr8134 ) or ( mll5584 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( p-hydroxycinnamoyl CoA hydratase/lyase ) or ( enoyl-CoA hydratase ) or ( carnitine racemase ) or ( enoyl-CoA hydratase ) or ( carnitinyl-CoA dehydratase ) or ( probable enoyl-CoA hydratase/isomerase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PALMITYL__45__COA_TO_CO__45__A_COF_RXN" name="PALMITYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PALMITYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLGLUTKIN__45__RXN" name="Acetylglutamate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4826_argB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylglutamate kinase (NAG kinase) (AGK) (N-acetyl-L- glutamate 5-phosphotransferase)//ACETYLGLUTKIN-RXN//Acetylglutamate kinase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULOKIN__45__RXN" name="L-ribulokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4918 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribitol kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.16</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribulose__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribulose__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7562" name="Acetylornithine aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5646_argD ) or ( mlr6714 ) or ( mll1261 ) or ( mll0107 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine aminotransferase (ACOAT)//ACETYLORNTRANSAM-RXN ) or ( ornithine-oxo-acid transaminase ) or ( probable aminotransferase ) or ( aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.11</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__3__46__9__45__RXN" name="Phosphoenolpyruvate--protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3436 ) or ( mll5291 ) or ( mll3609 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoenolpyruvate-protein phosphotransferase, PtsP ) or ( phosphoenolpyruvate-protein phosphotransferase ) or ( phosphotransferase system enzyme I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.3.9</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXI__45__RXN" name="Lactoylglutathione lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2252 ) or ( mlr4624 ) or ( mll0167 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable lactoylglutathione lyase ) or ( lactoylglutathione lyase ) or ( lactoylglutathione lyase )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.5</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8675" name="Uroporphyrinogen-III C-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3232 ) or ( mlr1386 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( siroheme synthetase [Rhizobium leguminosarum ) or ( uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__38__45__RXN" name="O-demethylpuromycin O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8050 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to ortho-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.38</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__DEMETHYLPUROMYCIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUROMYCIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__NUCLEOSID__45__RXN" name="AMP nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7714 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AMP nucleosidase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE__45__5P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENDECARBOX__45__RXN" name="Uroporphyrinogen decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4487_hemE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Uroporphyrinogen decarboxylase (URO-D) (UPD)//UROGENDECARBOX-RXN//Uroporphyrinogen decarboxylase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.37</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DSERDEAM__45__RXN" name="D-serine ammonia-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6666 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-serine deaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIMSYN3__45__RXN" name="Phosphomethylpyrimidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5788 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomethylpyrimidine kinase )</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.7</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYM__45__PHOSPH__45__RXN" name="Thymidine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3160_deoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thymidine phosphorylase (TdRPase)//THYM-PHOSPH-RXN//Thymidine phosphorylase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="THYMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTONDEHYDRAT__45__RXN" name="Galactonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2605 ) or ( mll9372 ) or ( mll7085 ) or ( mll7377 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable isomerase ) or ( putative dehydratase ) or ( 2-oxo-3-deoxygalactonate 6-phosphate aldolase and galactonate dehydratase ) or ( similar to 2-oxo-3-deoxygalactonate 6-phosphate aldolase and galactonate dehydratase )</html:p>
<html:p>SUBSYSTEM: D-galactonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GALACTONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETATE__45__DECARBOXYLASE__45__RXN" name="Acetoacetate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5917_adc1 ) or ( mlr3634_adc3 ) or ( mlr2399_adc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Probable acetoacetate decarboxylase 1 (ADC 1) (AAD 1) ) or ( Probable acetoacetate decarboxylase 3 (ADC 3) (AAD 3) ) or ( Probable acetoacetate decarboxylase 2 (ADC 2) (AAD 2) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPSYN__45__RXN" name="Tryptophan synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5071_trpB ) or ( mlr5073_trpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tryptophan synthase beta chain//RXN0-2382//TRYPSYN-RXN//Tryptophan synthase ) or ( Tryptophan synthase alpha chain//TRYPSYN-RXN//Tryptophan synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TSA__45__REDUCT__45__RXN" name="2-hydroxy-3-oxopropionate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0254 ) or ( mlr1689 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable oxidoreductase ) or ( 3-hydroxyisobutyrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.60</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7958" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6576 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7917_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5985" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9100 ) or ( mlr7548 ) or ( mll6007 ) or ( mll5831 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthase ) or ( probable biotin synthase ) or ( biotin synthase ) or ( biotin synthetase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5662" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3070 ) or ( mll5720 ) or ( mlr1913 ) or ( mlr1136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase) ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to ethanol II</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5984" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9100 ) or ( mlr7548 ) or ( mll6007 ) or ( mll5831 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthase ) or ( probable biotin synthase ) or ( biotin synthase ) or ( biotin synthetase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: CPD__45__249</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__249" stoichiometry="1"/>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__5662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__20" name="Magnesium chelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4733 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mg(2+) chelatase family protein )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.6.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: MG__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MG__43__2" stoichiometry="1"/>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MG__45__PROTOPORPHYRIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANDELATE__45__RACEMASE__45__RXN" name="Mandelate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7089 ) or ( mll7149 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to mandelate racemase ) or ( mandelate racemase )</html:p>
<html:p>SUBSYSTEM: mandelate degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__121" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__122" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__87__45__RXN" name="N-carbamoyl-L-amino-acid hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7658 ) or ( mll1631 ) or ( mlr7938 ) or ( mlr0967 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allantoate amidohydrolase ) or ( allantoate amidohydrolase ) or ( allantoate amidohydrolase ) or ( allantoate amidohydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.87</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Carbamoyl__45__L__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__2__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPYRIMIDINASE__45__RXN" name="Dihydropyrimidinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9131 ) or ( mll1629 ) or ( mlr4662 ) or ( mlr9030 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydantoinase ) or ( dihydropyrimidinase ) or ( hydantoinase ) or ( probable hydantoinase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CREATINASE__45__RXN" name="Creatinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6218 ) or ( mll5970 ) or ( mlr7141 ) or ( mlr2682 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable dipeptidase ) or ( putative peptidase ) or ( probable dipeptidase ) or ( probable hydrolase/peptidase )</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CREATINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DETHIOBIOTIN__45__SYN__45__RXN" name="dethiobiotin synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9098_bioD ) or ( mll6270_bioD ) or ( mll5829_bioD ) or ( mll6005_bioD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dithiobiotin synthetase//DETHIOBIOTIN-SYN-RXN ) or ( dithiobiotin synthetase//DETHIOBIOTIN-SYN-RXN ) or ( dithiobiotin synthetase//DETHIOBIOTIN-SYN-RXN ) or ( dithiobiotin synthetase//DETHIOBIOTIN-SYN-RXN )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGINASE__45__RXN" name="Arginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5015 ) or ( mll6778 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase ) or ( arginase )</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation VII (arginase 3 pathway)</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMDECARB__45__RXN" name="Diaminopimelate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3508 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaminopimelate decarboxylase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.20</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLATECYC__45__RXN" name="Adenylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4049 ) or ( mll4655 ) or ( mll4650 ) or ( mlr4588 ) or ( mll2000 ) or ( mll6463 ) or ( mlr1023 ) or ( mlr2019 ) or ( mll1022 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylate cyclase cya3 ) or ( adenylate cyclase cya3 ) or ( adenylate cyclase cya3 ) or ( adenylate cyclase ) or ( adenylate cyclase ) or ( similar to adenylate cyclase ) or ( adenylate cyclase ) or ( adenylate cyclase ) or ( adenylate cyclase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7929" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4422 ) or ( mll6008 ) or ( mlr1323 ) or ( mlr0906 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Citrate lyase beta chain (acyl lyase subunit) (citE) ) or ( citrate lyase beta-subunit ) or ( probable beta subunit of citrate lyase ) or ( citrate lyase beta chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.34</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3S__45__CITRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8670" name="Pentachlorophenol monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3850 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pentachlorophenol 4-monooxygenase; PcpB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.50</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__44__3__44__5__44__6__45__tetrachlorophenol" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRACHLOROHYDROQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACSERLY__45__RXN" name="Cysteine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4505 ) or ( mlr4651 ) or ( mlr0353 ) or ( mll4616 ) or ( mlr9541 ) or ( mll9227 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-synthase ) or ( cysteine synthase ) or ( cysteine synthase A ) or ( cysteine synthase, cytosolic O-acetylserine(thiol)lyase ) or ( cysteine synthase ) or ( cysteine synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.47</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCHOMOSERLYASE__45__RXN" name="O-succinylhomoserine (thiol)-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5651 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-succinylhomoserine sulfhydrylase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.48</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIB5PISOM__45__RXN" name="Ribose 5-phosphate epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( msr7277 ) or ( mll0526_rpiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose-5-phosphate isomerase ) or ( Ribose-5-phosphate isomerase A (Phosphoriboisomerase A) (PRI)//RIB5PISOM-RXN//Ribose-5-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__8__46__1__46__8__45__RXN" name="Atrazine chlorohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8318 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-formimino-L-glutamate deiminase )</html:p>
<html:p>SUBSYSTEM: atrazine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATRAZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYATRAZINE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCDEHYDROG__45__RXN" name="Glucose dehydrogenase (pyrroloquinoline-quinone)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1500 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.5.2</html:p>
<html:p>COFACTOR: __124__Ubiquinols__124__</html:p>
<html:p>COFACTOR: __124__Ubiquinones__124__</html:p>
<html:p>SIDE: __124__Ubiquinols__124__</html:p>
<html:p>SIDE: __124__Ubiquinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CELLULOSE__45__SYNTHASE__45__GDP__45__FORMING__45__RXN" name="Cellulose synthase (GDP-forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7873 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to cellulose synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.29</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CELLULOSE" stoichiometry="1"/>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__O__45__ACETTRAN__45__RXN" name="Serine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0175 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.30</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IPPISOM__45__RXN" name="Isopentenyl-diphosphate &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6371_fni )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Isopentenyl-diphosphate delta-isomerase (IPP isomerase) (Isopentenyl pyrophosphate isomerase) )</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDINE__45__AMMONIA__45__LYASE__45__RXN" name="Histidine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8321_hutH ) or ( mll0151 ) or ( mlr1730 ) or ( mll7124 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Histidine ammonia-lyase (Histidase)//Histidine ammonia-lyase ) or ( histidine ammonia-lyase ) or ( histidine ammonia-lyase ) or ( histidine ammonia-lyase )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.3</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROCANATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__28__45__RXN" name="Tryptophan--phenylpyruvate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0405 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__3__46__1__46__23__45__RXN" name="5-methylthioribose-1-phosphate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7284_mtnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylthioribose-1-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.23</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1063" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPOXANPRIBOSYLTRAN__45__RXN" name="Hypoxanthine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3520 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine-guanine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7931" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable enoyl-CoA hydratase/isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7221" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONDEHYDROG__45__RXN" name="Phosphogluconate dehydrogenase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3321 ) or ( mlr4206 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase ) or ( 6-phosphogluconate dehydrogenase-like protein )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0196_panC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pantothenate synthetase (PS) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme)//PANTOATE-BETA-ALANINE-LIG-RXN//Pantoate--beta-alanine ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOYL__45__LACTONE" stoichiometry="1"/>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7933" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7167 ) or ( mll7049 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylornithine deacetylase ) or ( acetylornithine deacetylase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7224" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAADEHYDROG__45__RXN" name="D-amino-acid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3980 ) or ( mll6285 ) or ( mlr9201_dadA3 ) or ( mlr5698_dadA2 ) or ( mll3992_dadA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-amino-acid dehydrogenase ) or ( D-amino acid dehydrogenase, small subunit ) or ( D-amino acid dehydrogenase 3 small subunit ) or ( D-amino acid dehydrogenase 2 small subunit ) or ( D-amino acid dehydrogenase 1 small subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7708" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0405 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: methionine degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PHE</html:p>
<html:p>SIDE: PHENYL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__73__45__RXN" name="Feruloyl esterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2444 ) or ( mll4511 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyhydroxybutyrate depolymerase ) or ( cinnamoyl ester hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.73</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Feruloyl__45__polysaccharides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
      <speciesReference species="__124__Polysaccharides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7706" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3070 ) or ( mll5720 ) or ( mlr1913 ) or ( mlr1136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase) ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: methionine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7036" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7037" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANINE__45__DEAMINASE__45__RXN" name="Guanine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5142 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine deaminase )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINE__45__OXIDASE__45__FLAVIN__45__CONTAINING__45__RXN" name="Amine oxidase (flavin-containing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6250_tynA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyramine oxidase//AMACETOXID-RXN//AMINEOXID-RXN//AMINEPHEN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYL__45__KIN__45__RXN" name="Guanylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7857_gmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Guanylate kinase (GMP kinase)//GUANYL-KIN-RXN//Guanylate kinase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9730 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-methyltransferase homolog )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine betaine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6142" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7700" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3070 ) or ( mll5720 ) or ( mlr1913 ) or ( mlr1136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase) ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation III</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7035" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9730 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-methyltransferase homolog )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine betaine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.49</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6141" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCEROLTRANSI__45__RXN" name="Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4258 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to phosphoglycerol transferase I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.20</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="1"/>
      <speciesReference species="__124__MDO__45__D__45__Glucoses__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__MDO__45__6__45__Glycerophospho__45__D__45__Glucoses__124__" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPDEHYRHAMREDUCT__45__RXN" name="dTDP-4-dehydrorhamnose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7553 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-6-deoxy-L-mannose-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.133</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__RHAMNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7908" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4350 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative pterin-4-alpha-carbinolamine dehydratase (PHS) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydratase) (PCD) )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.96</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7917_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMACETOXID__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6250_tynA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyramine oxidase//AMACETOXID-RXN//AMINEOXID-RXN//AMINEPHEN-RXN )</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7710" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7587_glgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,4-alpha-glucan-branching enzyme (Glycogen-branching enzyme) (BE) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl- transferase)//GLYCOGEN-BRANCH-RXN )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7711" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3093 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH oxidoreductase )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLOROMUCONATE__45__CYCLOISOMERASE__45__RXN" name="Chloromuconate cycloisomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7352 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__CL__45__5__45__OXO__45__2__45__5__45__DIH__45__FURAN__45__2__45__ACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__279" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__5__45__DEHYDROGENASE__45__RXN" name="Shikimate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4492_aroE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Shikimate dehydrogenase//SHIKIMATE-5-DEHYDROGENASE-RXN//Shikimate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.25</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__132__45__RXN" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1383 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 6y methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.132</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__679" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__686" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__ISOPROPYLMALATESYN__45__RXN" name="2-isopropylmalate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2792_leuA ) or ( mlr7805 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase)//2-isopropylmalate synthase ) or ( putative alpha-isopropylmalate/homocitrate synthase family transferase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.13</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYRAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0405 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine degradation III</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7911" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8292 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable N-methylproline demethylase (stahydrine utilization protein stcD) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRADEHYDROACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RETINOL__45__DEHYDROGENASE__45__RXN" name="Retinol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1899 ) or ( mlr2473 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( short chain dehydrogenase ) or ( short chain dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.105</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RETINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RETINAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMEPIM__45__RXN" name="Diaminopimelate epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4318_dapF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Diaminopimelate epimerase (DAP epimerase)//DIAMINOPIMEPIM-RXN//Diaminopimelate epimerase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6464" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9730 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-methyltransferase homolog )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine betaine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6142" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6181" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__19__45__RXN" name="Nucleoside-triphosphate pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0404_mazG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside triphosphate pyrophosphohydrolase//RXN0-1041 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7919" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2661 ) or ( mlr3546_gloB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable hydrolase ) or ( Hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)//GLYOXII-RXN//Hydroxyacylglutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__hydroxyacyl__45__glutathiones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Hydroxy__45__carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7913" name="Cytidylate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5212_cmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase)//CMPKI-RXN//Cytidylate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYISOVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7192 ) or ( mlr5404 ) or ( mll1102_ilvD2 ) or ( mlr5361_ilvD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxy-acid dehydratase ) or ( dihydroxy-acid dehydratase ) or ( Dihydroxy-acid dehydratase 2 (DAD 2)//Dihydroxy-acid dehydratase ) or ( Dihydroxy-acid dehydratase 1 (DAD 1)//Dihydroxy-acid dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PENTACHLOROPHENOL__45__MONOOXYGENASE__45__RXN" name="Pentachlorophenol monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3850 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pentachlorophenol 4-monooxygenase; PcpB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.50</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PENTACHLOROPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRACHLOROHYDROQUINONE" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETHYLBILANESYN__45__RXN" name="Hydroxymethylbilane synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4223_hemC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)//OHMETHYLBILANESYN-RXN//Hydroxymethylbilane synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.61</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__DEHYDROGENASE__45__RXN" name="Glycine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0885_gcvP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycine dehydrogenase [decarboxylating] (Glycine decarboxylase) (Glycine cleavage system P-protein)//GCVP-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.1.10</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DURIDKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2747_tdk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thymidine kinase//DURIDKI-RXN//THYKI-RXN//Thymidine kinase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLCROTONYL__45__COA__45__CARBOXYLASE__45__RXN" name="Methylcrotonyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7727 ) or ( mll6011 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methylcrotonyl-CoA carboxylase biotin-containing subunit ) or ( 3-methylcrotonyl-CoA carboxylase biotin-containing subunit )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PFRUCTPHOS__45__RXN" name="6-phosphofructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5025 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructokinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__157__45__RXN" name="Glucosamine-1-phosphate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0836_glmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]//2.3.1.157-RXN//NAG1P-URIDYLTRANS-RXN//Glucosamine-1-phosphate N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.157</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCOSAMINE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINOALANINE__45__AMINOTRANSFERASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2987 ) or ( mlr4213 ) or ( mlr9116 ) or ( mll0935 ) or ( mlr2541 ) or ( mlr9118 ) or ( mlr0210 ) or ( mlr5693 ) or ( mlr1282 ) or ( mlr5883 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate aminotransferase ) or ( aspartate aminotransferase ) or ( aspartate aminotransferase ) or ( aminotransferase ) or ( aspartate aminotransferase ) or ( aspartate transaminase ) or ( probable aminotransferase ) or ( aspartate aminotransferase ) or ( aspartate transaminase ) or ( aspartate transaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.1</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSCHOL__45__RXN" name="Phospholipase D" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9675 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phopholipase D-family protein )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CHOLINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__19__45__RXN" name="3-phosphoshikimate 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5213_aroA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-phosphoshikimate 1-carboxyvinyltransferase (5- enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS)//2.5.1.19-RXN//3-phosphoshikimate 1-carboxyvinyltransferase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.19</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BADH__45__RXN" name="Betaine-aldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7608_betB ) or ( mlr6969 ) or ( mlr5385 ) or ( mll2319 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Betaine aldehyde dehydrogenase (BADH)//BADH-RXN ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: choline degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis I (Gram-negative bacteria)</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis III (plants)</html:p>
<html:p>SUBSYSTEM: choline-O-sulfate degradation</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis II (Gram-positive bacteria)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPH__45__RXN" name="Phosphoglycolate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5413 ) or ( mlr0528_gph )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycolate phosphatase ) or ( Phosphoglycolate phosphatase (PGPase) (PGP)//GPH-RXN//Phosphoglycolate phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__67" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOTHENATE__45__KIN__45__RXN" name="Pantothenate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5019_coaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pantothenate kinase (Pantothenic acid kinase)//PANTOTHENATE-KIN-RXN//Pantothenate kinase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGEN__45__BRANCH__45__RXN" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7587_glgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,4-alpha-glucan-branching enzyme (Glycogen-branching enzyme) (BE) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl- transferase)//GLYCOGEN-BRANCH-RXN )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENODEAMIN__45__RXN" name="Adenosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3163_add )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenosine deaminase (Adenosine aminohydrolase)//ADENODEAMIN-RXN//Adenosine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINEOXID__45__RXN" name="Amine oxidase (copper-containing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6250_tynA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyramine oxidase//AMACETOXID-RXN//AMINEOXID-RXN//AMINEPHEN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNA__45__RXN" name="Aspartate--ammonia ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6743 ) or ( mlr6755 ) or ( mlr5888 ) or ( mll5256 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine synthetase ) or ( asparagine synthase ) or ( asparagine synthetase ) or ( similar to asparagine synthetase )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__44__45__RXN" name="Homospermidine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3014_hss )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Homospermidine synthase (HSS)//Homospermidine synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.44</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1821" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__CH3__45__2__45__OXOBUTANOATE__45__OH__45__CH3__45__XFER__45__RXN" name="3-methyl-2-oxobutanoate hydroxymethyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1731 ) or ( mlr7631 ) or ( mll0197_panB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methyl-2-oxobutanoate hydroxymethyltransferase ) or ( 3-methyl-2-oxobutanoate hydroxymethyltransferase ) or ( 3-methyl-2-oxobutanoate hydroxymethyltransferase (Ketopantoate hydroxymethyltransferase) (KPHMT)//3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN//3-methyl-2-oxobutanoate hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.11</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: METHYLENE__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYLPHOSPHATASE__45__RXN" name="Aryldialkylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7664 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to resiniferotoxin-binding, phosphotriesterase-related protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Dialkyl__45__Phosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
      <speciesReference species="__124__Dialkyl__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE__45__CARBOXYLASE__45__RXN" name="Pyruvate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3969 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate carboxylase )</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTCYCLOHYD__45__RXN" name="Phosphoribosyl-AMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0923_hisI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoribosyl-AMP cyclohydrolase (PRA-CH)//Phosphoribosyl-AMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__2__46__14__45__RXN" name="N-methylhydantoinase (ATP-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9031 ) or ( mlr4788 ) or ( mlr4786 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-methylhydantoinase ) or ( N-methylhydantoinase B ) or ( N-methylhydantoinase A (mikimopine-lactam hydrogenase) )</html:p>
<html:p>SUBSYSTEM: creatinine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__METHYLHYDANTOIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__99__46__4__45__RXN" name="&amp;alpha;-methylacyl-CoA racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2316 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable fatty acid Co-A racemase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__2__45__METHYLACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__2__45__METHYLACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R542__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3070 ) or ( mll5720 ) or ( mlr1913 ) or ( mlr1136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase) ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__863" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__864" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEPHOSPHOCOAKIN__45__RXN" name="Dephospho-CoA kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4493_coaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dephospho-CoA kinase (Dephosphocoenzyme A kinase)//DEPHOSPHOCOAKIN-RXN//Dephospho-CoA kinase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__11__46__1__46__15__45__RXN" name="Peroxiredoxin" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5873 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxiredoxin 2 family protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="2"/>
      <speciesReference species="__124__Alkyl__45__Hydro__45__Peroxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8269 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-D-manno-octulosonic-acid transferase )</html:p>
<html:p>SUBSYSTEM: KDO transfer to lipid IVA</html:p>
<html:p>PROTEIN_CLASS: 2.-.-.-</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LIPID__45__IV__45__A" stoichiometry="1"/>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO__45__LIPID__45__IVA" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPACYLGLCNACDEACETYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1545_lpxC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase )</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__OHMYR__45__ACETYLGLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="UDP__45__OHMYR__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHTHALATE__45__45__45__DIOXYGENASE__45__RXN" name="Phthalate 4,5-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7322 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( vanillate O-demethylase oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.7</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHTHALATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__45__45__DIHYDROXYCYCLOHEXA__45__162__45__DIENE__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULP3EPIM__45__RXN" name="ribulose phosphate 3-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7233 ) or ( mlr4760 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribulose-5-phosphate 3-epimerase ) or ( pentose(ribulose)-5-phosphate-3-epimerase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LXULRU5P__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3595 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Similar to D-tagatose 3-epimerase-related protein )</html:p>
<html:p>SUBSYSTEM: L-lyxose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__XYLULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__RIBULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCPHOSDIESTER__45__RXN" name="2&apos;,3&apos;-cyclic-nucleotide 2&apos;-phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0366_cpdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional 2&apos;,3&apos;-cyclic nucleotide 2&apos;-phosphodiesterase/3&apos;-nucleotidase periplasmic precursor protein//3-NUCLEOTID-RXN//CYCPHOSDIESTER-RXN//3&apos;-nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.16</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__2__45__3__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINKIN__45__RXN" name="Riboflavin kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8243 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional riboflavin kinase/FMN adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: 5,6-dimethylbenzimidazole biosynthesis</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R123__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1290 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosine deaminase )</html:p>
<html:p>SUBSYSTEM: atrazine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ISOPROPYLAMMELIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOPROPYLAMINE" stoichiometry="1"/>
      <speciesReference species="CYANURIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOHEXOKINASE__45__RXN" name="Ketohexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3644 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbohydrate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEHYDR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4335 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitate hydratase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDDEHYDROG__45__RXN" name="Lactaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1015 ) or ( mll2867 ) or ( mll7045 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-D-GLUCOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5114" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1449 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable phosphoserine phosphatase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5116" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4918 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribitol kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.16</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__RIBULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__RIBULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDINE__45__DECARBOXYLASE__45__RXN" name="Histidine decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6209_hdc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Histidine decarboxylase (HDC)//Histidine decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5118" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2566 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-heptose-LPS heptosyltransferase )</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.-.-</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
      <speciesReference species="KDO2__45__LIPID__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__929" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__1__46__8__45__RXN" name="Lipoyl synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0392_lipA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Lipoyl synthase (Lipoic acid synthase) (Lipoate synthase) (Sulfur insertion protein lipA) (Lip-syn) (LS)//Lipoyl synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
      <speciesReference species="S8" stoichiometry="2"/>
      <speciesReference species="__124__Protein__45__6__45__N__45__octanoyl__45__lysine__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="MET" stoichiometry="2"/>
      <speciesReference species="__124__Protein__45__6__45__N__45__lipoyl__45__lysine__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R223__45__RXN" name="long-chain-fatty-acid-CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7537 ) or ( mlr7293 ) or ( mlr6974 ) or ( mlr1843 ) or ( mlr6932 ) or ( mll5415 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA synthetase ) or ( acyl-CoA synthetase ) or ( acyl-CoA synthetase ) or ( acyl-CoA synthetase ) or ( acyl-CoA synthetase ) or ( acyl-CoA synthetase )</html:p>
<html:p>SUBSYSTEM: octane oxidation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTANOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXKIN__45__RXN" name="Pyridoxal kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4132 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxamine kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPPSYN__45__RXN" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7442_ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase )</html:p>
<html:p>SUBSYSTEM: geranyldiphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: geranylgeranyldiphosphate biosynthesis II (plastidic)</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNCARBAMTRANSFER__45__RXN" name="Ornithine carbamoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8442 ) or ( mll7185 ) or ( mlr9382 ) or ( mlr5647_argF ) or ( mlr7545 ) or ( mlr4191 ) or ( mlr5384 ) or ( mll2949 ) or ( mlr6967 ) or ( mlr3665 ) or ( mll1739 ) or ( mlr7381 ) or ( mll0233 ) or ( mlr1667 ) or ( mll2887 ) or ( mlr9016 ) or ( mlr6080 ) or ( mlr6537 ) or ( mlr2022 ) or ( mll6253 ) or ( mlr4192 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ABC transporter, permease protein ) or ( ABC transporter, permease protein ) or ( permease of ABC transporter ) or ( Ornithine carbamoyltransferase (OTCase)//ORNCARBAMTRANSFER-RXN//Ornithine carbamoyltransferase ) or ( ABC transporter permease protein ) or ( spermidine/putrescine ABC transporter, permease protein ) or ( ABC transporter, permease protein ) or ( ABC transporter, permease protein ) or ( ABC transporter, permease protein ) or ( spermidine/putrescine ABC transporter, permease protein ) or ( permease protein of polyamine ABC transporter ) or ( ABC transporter, permease protein ) or ( probable permease of ABC transporter ) or ( permease protein of sulfate ABC transporter ) or ( ABC transporter, permease ) or ( ABC transporter, permease ) or ( ABC transporter, permease ) or ( ABC transporter, polyamine transport protein, permease protein ) or ( permease protein of spermidine/putrescine ABC transporter ) or ( ABC transporter permease protein ) or ( spermidine/putrescine ABC transporter, permease protein )</html:p>
<html:p>SUBSYSTEM: citrulline degradation</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine degradation V (arginine deiminase pathway)</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDRAT__45__RXN" name="Prephenate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5498 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prephenate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.51</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINSYN__45__RXN" name="argininosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4366_argG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Argininosuccinate synthase (Citrulline--aspartate ligase)//ARGSUCCINSYN-RXN//Argininosuccinate synthase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2441" name="Trans-aconitate 2-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1606_tam )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Trans-aconitate 2-methyltransferase//RXN0-2441//Trans-aconitate 2-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.144</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__225" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MONOMETHYL__45__ESTER__45__OF__45__TRANS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6081" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: butanediol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8086" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4194 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to macrolide glycosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7610" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7612" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0765 ) or ( mlr3159 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase ) or ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__131__45__RXN" name="Precorrin-3B C17-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1381 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin-3B C17-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.131</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__643" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__651" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1082" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4183 ) or ( mll4181 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetate CoA-transferase, alpha subunit ) or ( acetoacetyl-CoA transferase b subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="R__45__2__45__HYDROXYGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXYGLUTARYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMETB12__45__RXN" name="5-methyltetrahydrofolate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6206 ) or ( msl6205 ) or ( mlr1220 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to 5-methyltetrahydrofolate-homocysteine S-methyltransferase ) or ( similar to 5-methyltetrahydrofolate-homocysteine S-methyltransferase ) or ( methionine synthase I )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__156__45__RXN" name="Adenosylcobinamide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1308 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cobinamide kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.156</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Triphosphates__124__" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Diphosphates__124__" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0015 ) or ( mll5865 ) or ( mlr0102 ) or ( mll5421 ) or ( mlr0021 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrogenase cofactor synthesis protein nifS ) or ( nitrogenase cofactor synthesis protein nifS ) or ( aminotransferase ) or ( aminotransferase nifS ) or ( nifS-like aminotransferase )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ENZYME__45__S__45__SULFANYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__302" name="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0395_ispDF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional enzyme ispD/ispF [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase (4-diphosphocytidyl-2C- methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT); 2-C- methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS) (MECDP-synthase)] )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.12</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOVALERYL__45__COA__45__FAD__45__RXN" name="Isovaleryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7732 ) or ( mlr6975 ) or ( mll0685 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isovaleryl-CoA-dehydrogenase ) or ( probable acyl-CoA dehydrogenase ) or ( probable acyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROURACIL__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Dihydrouracil dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1643 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydropyrimidine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R342__45__RXN" name="Cobaltochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1377_cobN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cobaltochelatase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 6.6.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CO__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__43__2" stoichiometry="1"/>
      <speciesReference species="CPD__45__688" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__689" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__1__46__2__45__RXN" name="Precorrin-8X methylmutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1379_cobH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin-8X methylmutase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 5.4.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__686" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__687" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FADSYN__45__RXN" name="FMN adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8243 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional riboflavin kinase/FMN adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.2</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8093" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4880 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANIAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8092" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4880 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0765 ) or ( mlr3159 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase ) or ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8094" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4880 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7620" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7619" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5141" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8386 ) or ( mlr0100 ) or ( mlr6441 ) or ( mll0645 ) or ( mlr4079 ) or ( mlr4087 ) or ( mll1952 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxido-reductase, and dehydratase mocA ) or ( oxidoreductase ) or ( similar to oxidoreductase ) or ( probable oxidoreductase ) or ( oxidoreductase ) or ( oxidoreductase, mocA ) or ( norsolorinic acid reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.91</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__703" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__702" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxybutyrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2400 ) or ( mll3632 ) or ( mlr3482 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyrate dehydrogenase ) or ( D-beta-hydroxybutyrate dehydrogenase ) or ( short chain dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.30</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__335" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMATE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Glutamate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3461_argJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Arginine biosynthesis bifunctional protein argJ [Includes: Glutamate N-acetyltransferase (Ornithine acetyltransferase) (Ornithine transacetylase) (OATase); Amino-acid acetyltransferase (N-acetylglutamate synthase) (AGS)] [Contains: Arginine biosynthesis bifunctional protein argJ alpha chain; Arginine biosynthesis bifunctional protein argJ beta chain]//Glutamate N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.35</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R310__45__RXN" name="Nitrile hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1423 ) or ( mll1425 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrile hydratase beta subunit ) or ( nitrile hydratase alpha subunit )</html:p>
<html:p>SUBSYSTEM: acrylonitrile degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLONITRILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYLGLUCOSAMINE__45__4__45__EPIMERASE__45__RXN" name="UDP-N-acetylglucosamine 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6767 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable UDP-glucose 4-epimerase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPDEPHOS__45__RXN" name="Pyruvate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3819 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.40</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTACONATE__45__COA__45__TRANSFERASE__45__RXN" name="glutaconate CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4183 ) or ( mll4181 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetate CoA-transferase, alpha subunit ) or ( acetoacetyl-CoA transferase b subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTACONATE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTACONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0079 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBDEHYDROG__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1160 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8486" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopamine)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8659" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__ACETYLHOMOSERINE__45__THIOL__45__LYASE__45__RXN" name="O-acetylhomoserine (thiol)-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8465 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-acetylhomoserine aminocarboxypropyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.49</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7671" stoichiometry="1"/>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOENOLPYRUVATE__45__MUTASE__45__RXN" name="Phosphoenolpyruvate mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5882 ) or ( mlr9115 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoenolpyruvate Mutase ) or ( phosphoenolpyruvate phosphomutase )</html:p>
<html:p>SUBSYSTEM: fosfomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__235" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8023" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3676 ) or ( mlr3674 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phytoene dehydrogenase ) or ( phytoene dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7408" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8024" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3676 ) or ( mlr3674 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phytoene dehydrogenase ) or ( phytoene dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7408" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__98" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOPORGENOXI__45__RXN" name="Protoporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4722 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoporphyrinogen oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLU6PDEHYDROG__45__RXN" name="Glucose-6-phosphate 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6516 ) or ( mlr4207 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate 1-dehydrogenase ) or ( glucose-6-phosphate 1-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.49</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEAM__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1566 ) or ( mll4503 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine gamma-lyase ) or ( cystathionine gamma-lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CAFFEOYL__45__COA__45__O__45__METHYLTRANSFERASE__45__RXN" name="Caffeoyl-CoA O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0279 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.104</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CAFFEOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FERULOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NANK__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7234 ) or ( mlr3412 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose kinase ) or ( glucokinase )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine , N-acetylmannosamine and N-acetylneuraminic acid dissimilation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.60</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PADENYLTRANS__45__RXN" name="Glucose-1-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7588_glgC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glucose-1-phosphate adenylyltransferase (ADP-glucose synthase) (ADP-glucose pyrophosphorylase) (ADPGlc PPase)//GLUC1PADENYLTRANS-RXN//Glucose-1-phosphate adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.27</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSDECARB__45__RXN" name="Phosphopantothenoylcysteine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3167 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.36</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__HALOACID__45__DEHALOGENASE__45__RXN" name="2-haloacid dehalogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4579 ) or ( mlr7041 ) or ( mll7634 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-haloalkanoic acid dehalogenase ) or ( similar to haloalkanoic acid dehalogenase ) or ( 2-haloacid halidohydrolase Iva )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__2__45__Haloacids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__R__45__2__45__Hydroxyacids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Halides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UMPKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5212_cmk ) or ( mll0643_pyrH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase)//CMPKI-RXN//Cytidylate kinase ) or ( Uridylate kinase (UK) (Uridine monophosphate kinase) (UMP kinase) )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATEKIN__45__RXN" name="Aspartate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3437 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate kinase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__164__45__RXN" name="Isopenicillin N N-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9373 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA-6-aminopenicillanic acid acyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.164</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__207" stoichiometry="1"/>
      <speciesReference species="ISOPENICILLIN__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PENICILLIN__45__G" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__81" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7934 ) or ( mlr4561 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to dimethylaniline monooxygenase ) or ( dimethylaniline monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2743" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTALDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7107_hisD3 ) or ( mlr6649_hisD2 ) or ( mll6456_hisD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Histidinol dehydrogenase 3 (HDH 3)//Histidinol dehydrogenase ) or ( Histidinol dehydrogenase 2 (HDH 2)//Histidinol dehydrogenase ) or ( Histidinol dehydrogenase 1 (HDH 1)//Histidinol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FGAMSYN__45__RXN" name="phosphoribosylformylglycinamidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0057_purL ) or ( msl0067 ) or ( mll0065_purQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoribosylformylglycinamidine synthase II (FGAM synthase II)//Phosphoribosylformylglycinamidine synthase ) or ( phosphoribosylformylglycinamidine synthase subunit PurS ) or ( Phosphoribosylformylglycinamidine synthase 1 (Phosphoribosylformylglycinamidine synthase I) (FGAM synthase I)//Phosphoribosylformylglycinamidine synthase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTPPYPHOSKIN__45__RXN" name="GTP diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7755 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP pyrophosphokinase )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__TP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOGENTISATE__45__12__45__DIOXYGENASE__45__RXN" name="Homogentisate 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8303_hmgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Homogentisate 1,2-dioxygenase (Homogentisicase) (Homogentisate oxygenase) (Homogentisic acid oxidase)//Homogentisate 1,2-dioxygenase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.5</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__FORMYLGLUTAMATE__45__DEFORMYLASE__45__RXN" name="N-formylglutamate deformylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8322 ) or ( mll3040 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-formylglutamate amidohydrolase hutG ) or ( N-formylglutamate amidohydrolase )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.68</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__600" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5876 ) or ( mlr6365 ) or ( mll6125 ) or ( mlr5192 ) or ( mlr6367 ) or ( mlr6364 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 ) or ( cytochrome P-450 ) or ( cytochrome P450-family protein ) or ( similar to cytochrome P450 ) or ( cytochrome P450 ) or ( cytochrome P-450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLYLSULFKIN__45__RXN" name="Adenylylsulfate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7576 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein )</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.25</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_PROPIONYL__45__COA_COF_RXN" name="CO-A_TO_PROPIONYL-COA_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8014" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4051 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.68</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SINAPALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SINAPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="POLYPHOSPHATE__45__KINASE__45__RXN" name="Polyphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8161 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyphosphate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5521 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8631" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7221 ) or ( mll7273 ) or ( mlr3754 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PUTATIVE ALDOLASE ) or ( fructose-1,6-bisphosphate aldolase ) or ( fructose-bisphosphate aldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__2__46__12__45__RXN" name="6-aminohexanoate-cyclic dimer hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4825 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-aminohexanoate-cyclic-dimer hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_18__45__DIAZACYCLOTETRADECANE__45__29__45__DIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__6__45__AMINOHEXANOYL__45__6__45__AMINOHEXANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__7__46__1__46__13__45__RXN" name="Queuine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8291_queF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADPH-dependent 7-cyano-7-deazaguanine reductase (7- cyano-7-carbaguanine reductase) (PreQ(0) reductase) (NADPH-dependent nitrile oxidoreductase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.13</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUEUINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8988" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GABATRANSAM__45__RXN" name="4-aminobutyrate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5521 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE__45__OXID__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5834_nadB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-aspartate oxidase (LASPO) (Quinolinate synthetase B)//L-aspartate oxidase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.-</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMINOASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLSULFAT__45__RXN" name="Arylsulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5471 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylsulfatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Sulfate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__83" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4194 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to macrolide glycosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2744" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__ATP__45__RXN" name="DNA ligase (ATP)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9524 ) or ( mll5481 ) or ( mll8063_ligC ) or ( mll4606 ) or ( mll6696 ) or ( mll9685_ligC ) or ( mll2077 ) or ( mll9625_ligD ) or ( mlr8042 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA ligase homolog ) or ( DNA ligase ) or ( ATP-dependent DNA ligase ) or ( ATP-dependent DNA ligase ) or ( similar to DNA ligase ) or ( ATP-dependent DNA ligase ) or ( probable ATP-dependent DNA ligase ) or ( ATP-dependent DNA ligase ) or ( similar to ATP-dependent DNA ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_SUC_COF_RXN" name="2-KETOGLUTARATE_TO_SUC_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__36__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (GDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9595 ) or ( msr9761 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate synthase ) or ( similar to trehalose-6-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.36</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__3__46__2__46__9__45__RXN" name="Microsomal epoxide hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2710 ) or ( mlr6682 ) or ( mlr4436 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable hydrolase ) or ( epoxide hydrolase ) or ( contains similarity to hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8984" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8985" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSHTRAN__45__RXN" name="Glutathione transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0559 ) or ( mlr0981 ) or ( mlr1135 ) or ( mlr2052 ) or ( mlr8180 ) or ( mll2536 ) or ( mlr2042 ) or ( mll3731 ) or ( mll4939 ) or ( mll0063 ) or ( mlr1410 ) or ( mll4614 ) or ( mlr7058 ) or ( mlr4635 ) or ( mll3775 ) or ( mlr4954 ) or ( mll0034 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( putative glutathione S-transferase YghU ) or ( probable glutathione S-transferase ) or ( probable glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione transferase ) or ( glutathione-S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( similar to glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione S-transferase III )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RX" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HX" stoichiometry="1"/>
      <speciesReference species="__124__S__45__Substituted__45__Glutathione__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTARYL__45__COA__45__DEHYDROGENASE__45__RXN" name="Glutaryl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2878 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl Co-A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOCATECHUATE__45__34__45__DIOXYGENASE__45__RXN" name="Protocatechuate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7208 ) or ( mlr7210 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protocatechuate 3,4-dioxygenase beta chain ) or ( protocatechuate 3,4-dioxygenase alpha chain )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.3</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__245" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOLINATE__45__SYNTHE__45__MULTI__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5834_nadB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-aspartate oxidase (LASPO) (Quinolinate synthetase B)//L-aspartate oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8447" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__AMINO__45__PROPAN__45__2__45__ONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG1P__45__URIDYLTRANS__45__RXN" name="UDP-N-acetylglucosamine pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0836_glmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase ]//2.3.1.157-RXN//NAG1P-URIDYLTRANS-RXN//Glucosamine-1-phosphate N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.23</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_12__45__OXOPHYTODIENOATE__45__REDUCTASE__45__RXN" name="12-oxophytodienoate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2211 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( morphinone reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__729" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__730" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R147__45__RXN" name="Acireductone dioxygenase (Fe(2+)-requiring)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.54</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7567" name="nitrile hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1423 ) or ( mll1425 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrile hydratase beta subunit ) or ( nitrile hydratase alpha subunit )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLEYL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__237" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADDALT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3163_add )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenosine deaminase (Adenosine aminohydrolase)//ADENODEAMIN-RXN//Adenosine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYINOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__METHYLTHIOADENOSINE__45__PHOSPHORYLASE__45__RXN" name="5&apos;-methylthioadenosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7546 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to 5&apos;-methylthioadenosine phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__2__46__10__45__RXN" name="UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1559 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__209" stoichiometry="1"/>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALSYN__45__RXN" name="malate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4664_glcB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Malate synthase G//MALSYN-RXN//Malate synthase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.9</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5876 ) or ( mlr6365 ) or ( mll6125 ) or ( mlr5192 ) or ( mlr6367 ) or ( mlr6364 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 ) or ( cytochrome P-450 ) or ( cytochrome P450-family protein ) or ( similar to cytochrome P450 ) or ( cytochrome P450 ) or ( cytochrome P-450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2750" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYL__45__ALCOHOL__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2491 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__Aldehyde__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__162" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4194 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to macrolide glycosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2750" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2752" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5876 ) or ( mlr6365 ) or ( mll6125 ) or ( mlr5192 ) or ( mlr6367 ) or ( mlr6364 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 ) or ( cytochrome P-450 ) or ( cytochrome P450-family protein ) or ( similar to cytochrome P450 ) or ( cytochrome P450 ) or ( cytochrome P-450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2751" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PORPHOBILSYNTH__45__RXN" name="Porphobilinogen synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8390 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-aminolevulinic acid dehydratase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.24</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__168" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4194 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to macrolide glycosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2747" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__169" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5876 ) or ( mlr6365 ) or ( mll6125 ) or ( mlr5192 ) or ( mlr6367 ) or ( mlr6364 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 ) or ( cytochrome P-450 ) or ( cytochrome P450-family protein ) or ( similar to cytochrome P450 ) or ( cytochrome P450 ) or ( cytochrome P-450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3188" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5184" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7586 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R344__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1306 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)alamin adenosyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__694" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7593 ) or ( mll5109 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycosyl hydrolase ) or ( alpha-glucosidase )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OXOGLUT__45__DECARBOX__45__RXN" name="2-oxoglutarate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4301_kgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-ketoglutarate decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.71</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCCINATE__45__SEMIALDEHYDE__45__THIAMINE__45__PPI" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5180" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0640_uppS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Undecaprenyl pyrophosphate synthetase (UPP synthetase) (Di-trans,poly-cis-decaprenylcistransferase) (Undecaprenyl diphosphate synthase) (UDS)//Di-trans,poly-cis-decaprenylcistransferase )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATEORTHOPHOSPHATE__45__DIKINASE__45__RXN" name="Pyruvate,phosphate dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7532 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate phosphate dikinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7586 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R311__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7070 ) or ( mll3370 ) or ( mlr9017 ) or ( mlr2310 ) or ( mlr5350 ) or ( mlr2975 ) or ( mlr3187 ) or ( mlr0229 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidase ) or ( amidase ) or ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( amidase ) or ( probable amidase ) or ( amidase ) or ( amidase ) or ( amidase )</html:p>
<html:p>SUBSYSTEM: acrylonitrile degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__62" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4880 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEHYDDEOXPHOSGALACT__45__ALDOL__45__RXN" name="2-dehydro-3-deoxyphosphogalactonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4743 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-dehydro-3-deoxy-6-phosphogalactonate aldolase )</html:p>
<html:p>SUBSYSTEM: D-galactonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDRO__45__DEOXY__45__GALACTONATE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__61" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5876 ) or ( mlr6365 ) or ( mll6125 ) or ( mlr5192 ) or ( mlr6367 ) or ( mlr6364 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 ) or ( cytochrome P-450 ) or ( cytochrome P450-family protein ) or ( similar to cytochrome P450 ) or ( cytochrome P450 ) or ( cytochrome P-450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOSE__45__6__45__PHOSPHATE__45__PHOSPHOKETOLASE__45__RXN" name="Fructose-6-phosphate phosphoketolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6575 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Probable phosphoketolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBREDUCT__45__RXN" name="Pyrroline-5-carboxylate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6498 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrroline-5-carboxylate reductase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPCARBTRANS__45__RXN" name="Aspartate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0686_pyrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aspartate carbamoyltransferase (Aspartate transcarbamylase) (ATCase)//ASPCARBTRANS-RXN//Aspartate carbamoyltransferase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.2</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7045 ) or ( mll2867 ) or ( mll1015 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation II</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6940 ) or ( mlr2101 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catalase/peroxidase ) or ( catalase )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5876 ) or ( mlr6365 ) or ( mll6125 ) or ( mlr5192 ) or ( mlr6367 ) or ( mlr6364 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 ) or ( cytochrome P-450 ) or ( cytochrome P450-family protein ) or ( similar to cytochrome P450 ) or ( cytochrome P450 ) or ( cytochrome P-450 )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8442" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0765 ) or ( mlr3159 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase ) or ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="D__45__RIBULOSE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8259" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8441" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2009 ) or ( mll3190 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine-uridine preferring nucleoside hydrolase ) or ( nucleoside hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRCARBOXY__45__RXN" name="Phosphoribosylaminoimidazole carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3809 ) or ( mlr3811 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase I ) or ( phosphoribosylaminoimidazole carboxylase ATPase subunit )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.21</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DALADALALIG__45__RXN" name="D-alanine--D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6296 ) or ( mll1551_ddlB ) or ( mll1812_ddlA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative carboxylase ) or ( D-alanine--D-alanine ligase B (D-alanylalanine synthetase B) (D-Ala-D-Ala ligase B)//DALADALALIG-RXN//D-alanine--D-alanine ligase ) or ( D-alanine--D-alanine ligase A (D-alanylalanine synthetase A) (D-Ala-D-Ala ligase A)//DALADALALIG-RXN//D-alanine--D-alanine ligase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8813" name="Trans-pentaprenyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7426 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl-diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIENOYLCOAREDUCT__45__RXN" name="2,4-dienoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8292 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable N-methylproline demethylase (stahydrine utilization protein stcD) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="T2__45__DECENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="T2__45__C4__45__DECADIENYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R322__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1461 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 6A synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.152</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__662" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__675" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXII__45__RXN" name="Hydroxyacylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2661 ) or ( mlr3546_gloB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable hydrolase ) or ( Hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)//GLYOXII-RXN//Hydroxyacylglutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PPENTOMUT__45__RXN" name="Phosphopentomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5587_deoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphopentomutase (Phosphodeoxyribomutase)//D-PPENTOMUT-RXN//PPENTOMUT-RXN//Phosphopentomutase )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DXS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7474_dxs ) or ( mll5764 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose-5-phosphate synthase (1-deoxyxylulose- 5-phosphate synthase) (DXP synthase) (DXPS)//DXS-RXN//1-deoxy-D-xylulose-5-phosphate synthase ) or ( transketolase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.7</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALDEHYDROG__45__RXN" name="3-isopropylmalate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4399_leuB ) or ( mll7044 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydrogenase (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH)//3-ISOPROPYLMALDEHYDROG-RXN//3-isopropylmalate dehydrogenase ) or ( 3-isopropylmalate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.85</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8809" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9373 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA-6-aminopenicillanic acid acyltransferase )</html:p>
<html:p>SUBSYSTEM: penicillin K biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.164</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CPD__45__195</html:p>
<html:p>SIDE: CPD__45__196</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__196" stoichiometry="1"/>
      <speciesReference species="ISOPENICILLIN__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
      <speciesReference species="CPD__45__9122" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXY__45__MANDELATE__45__RACEMASE__45__RXN" name="Mandelate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7089 ) or ( mll7149 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to mandelate racemase ) or ( mandelate racemase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__105" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__106" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEYLACETOACETATE__45__ISOMERASE__45__RXN" name="Maleylacetoacetate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0981 ) or ( mlr1135 ) or ( mll0063 ) or ( mlr2042 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione S-transferase ) or ( glutathione S-transferase ) or ( glutathione transferase ) or ( glutathione S-transferase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METBALT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5651 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-succinylhomoserine sulfhydrylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.48</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__76__45__RXN" name="Arylmalonate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7137 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylmalonate decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.76</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ARYL__45__2__45__METHYLMALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ARYLPROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3070 ) or ( mll5720 ) or ( mlr1913 ) or ( mlr1136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase) ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis II (Gram-positive bacteria)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1K__45__87" name="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4780 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__787" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1401" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGENSYN__45__RXN" name="Starch (bacterial glycogen) synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7589_glgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycogen synthase (Starch [bacterial glycogen] synthase)//GLYCOGENSYN-RXN )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.21</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPCOASYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3094 ) or ( mlr1201 ) or ( mlr5042 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5199" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0765 ) or ( mlr3159 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase ) or ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP cyclohydrolase I" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0922_folE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP cyclohydrolase I (GTP-CH-I)//GTP-CYCLOHYDRO-I-RXN//GTP cyclohydrolase I )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.16</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__60__45__RXN" name="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0395_ispDF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional enzyme ispD/ispF [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase (4-diphosphocytidyl-2C- methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT); 2-C- methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS) (MECDP-synthase)] )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.60</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__77__45__RXN" name="N-carbamoyl-D-amino acid hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3450 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to nitrilase, nitrilase 1 like protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.77</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Carbamoyl__45__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPCARBOXYKIN__45__RXN" name="Phosphoenolpyruvate carboxykinase (ATP)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5096_pckA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoenolpyruvate carboxykinase [ATP] (PEP carboxykinase) (Phosphoenolpyruvate carboxylase) (PEPCK) )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.49</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOASYN__45__RXN" name="long-chain-fatty-acid--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7537 ) or ( mll6742 ) or ( mlr7293 ) or ( mlr6974 ) or ( mlr1843 ) or ( mlr6932 ) or ( mll5415 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA synthetase ) or ( long chain acyl-CoA synthetase ) or ( acyl-CoA synthetase ) or ( acyl-CoA synthetase ) or ( acyl-CoA synthetase ) or ( acyl-CoA synthetase ) or ( acyl-CoA synthetase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUTP__45__PYROP__45__RXN" name="dUTP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0404_mazG ) or ( mll5345_dut )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside triphosphate pyrophosphohydrolase//RXN0-1041 ) or ( Deoxyuridine 5&apos;-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase)//DUTP-PYROP-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOLACT__45__RXN" name="Gluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4328 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gluconolactonase )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINASE__45__RXN" name="Adenosylhomocysteinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5088_ahcY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase)//Adenosylhomocysteinase )</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>PROTEIN_CLASS: 3.3.1.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2661" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7523 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenine glycosylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__With__45__G__45__A__45__Mismatch__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__DNA__45__With__45__Mismatched__45__Adenine__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNB__45__RXN" name="asparagine synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6743 ) or ( mlr6755 ) or ( mlr5888 ) or ( mll5256 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine synthetase ) or ( asparagine synthase ) or ( asparagine synthetase ) or ( similar to asparagine synthetase )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.4</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__METHOXY__45__BENZOQ__45__METH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3165_ubiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ubiquinone/menaquinone biosynthesis methyltransferase ubiE )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHOXY__45__BENZOQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__821" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1160 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2763_fhs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Formate--tetrahydrofolate ligase (Formyltetrahydrofolate synthetase) (FHS) (FTHFS)//Formate--tetrahydrofolate ligase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6508_folD1 ) or ( mll6921_folD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional protein folD 1 [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//Methenyltetrahydrofolate cyclohydrolase ) or ( Bifunctional protein folD 2 [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//Methenyltetrahydrofolate cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5727" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOKIN__45__RXN" name="Glucokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7234 ) or ( mlr4640_glk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose kinase ) or ( Glucokinase (Glucose kinase)//GLUCOKIN-RXN//Glucokinase )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: trehalose degradation IV</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="ribose-phosphate diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2685_prs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ribose-phosphate pyrophosphokinase (RPPK) (Phosphoribosyl pyrophosphate synthetase) (P-Rib-PP synthetase) (PRPP synthetase) )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__76__45__RXN" name="Diaminobutyrate-2-oxoglutarate transaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5943 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaminobutyrate--2-oxoglutarate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.76</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__470" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENINE__45__DEAMINASE__45__RXN" name="adenine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4451 ) or ( mlr0157_ade )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotase ) or ( Adenine deaminase (Adenase) (Adenine aminase)//ADENINE-DEAMINASE-RXN//Adenine deaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8001" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7107_hisD3 ) or ( mlr6649_hisD2 ) or ( mll6456_hisD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Histidinol dehydrogenase 3 (HDH 3)//Histidinol dehydrogenase ) or ( Histidinol dehydrogenase 2 (HDH 2)//Histidinol dehydrogenase ) or ( Histidinol dehydrogenase 1 (HDH 1)//Histidinol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLESTERASE__45__RXN" name="Arylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0387 ) or ( mlr4347 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylesterase ) or ( acyl-CoA thioesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phenyl__45__Acetates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAMKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4132 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxamine kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLORIDE__45__PEROXIDASE__45__RXN" name="Chloride peroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6871 ) or ( mlr0493 ) or ( mll2689 ) or ( mlr0978 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloroperoxidase; thiocarbamate-inducible non-heme haloperoxidase ) or ( probable peroxidase ) or ( non-heme chloroperoxidase ) or ( non-heme chloroperoxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.10</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CL__45__" stoichiometry="2"/>
      <speciesReference species="RH" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Chlorides__124__" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3321 ) or ( mlr4206 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase ) or ( 6-phosphogluconate dehydrogenase-like protein )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__21__46__3__46__1__45__RXN" name="Isopenicillin-N synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0111 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxidoreductase )</html:p>
<html:p>SUBSYSTEM: isopenicillin N biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.21.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__5S__45__5__45__AMINO__45__5__45__CARBOXYPENTANOYL__45__L__45__CY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOPENICILLIN__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSINE__45__NUCLEOSIDASE__45__RXN" name="Adenosine nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2009 ) or ( mll3190 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine-uridine preferring nucleoside hydrolase ) or ( nucleoside hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCLOHEXADIENYL__45__DEHYDROGENASE__45__RXN" name="Cyclohexadienyl dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3535 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyclohexadienyl dehydrogenase )</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.43</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__659" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOACYLCOATHIOL__45__RXN" name="Acetyl-CoA C-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4180 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-ketoadipyl CoA thiolase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.16</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__KINASE__45__RXN" name="shikimate-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3573_aroK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Shikimate kinase (SK)//SHIKIMATE-KINASE-RXN//Shikimate kinase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.71</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__OXIDASE__45__RXN" name="Aldehyde oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4880 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOKIN__45__RXN" name="Ribokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1743 ) or ( mlr3185 ) or ( mlr3534 ) or ( mll7662 ) or ( mlr8492 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribokinase ) or ( ribokinase ) or ( probable sugar kinase ) or ( ribokinase ) or ( ribokinase )</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.15</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ESTRADIOL__45__17__45__BETA__45__DEHYDROGENASE__45__RXN" name="Estradiol 17 &amp;beta;-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0352 ) or ( mlr2833 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable oxidoreductase ) or ( short chain dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.62</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__352" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ESTRONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACECOATRANS__45__RXN" name="Acetate CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4183 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetate CoA-transferase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3749 ) or ( mll5764 ) or ( mll5765 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase ) or ( transketolase ) or ( transketolase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__KIN__45__RXN" name="NAD(+) kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0225_ppnK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Probable inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase) )</html:p>
<html:p>SUBSYSTEM: NAD phosphorylation and dephosphorylation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.23</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGININE__45__DEIMINASE__45__RXN" name="Arginine deiminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6733_arcA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Arginine deiminase (ADI) (Arginine dihydrolase) (AD)//Arginine deiminase )</html:p>
<html:p>SUBSYSTEM: arginine degradation V (arginine deiminase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__IDITOL__45__2__45__DEHYDROGENASE__45__RXN" name="L-iditol 2-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7108 ) or ( mll5168 ) or ( mll4921 ) or ( mlr3340 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase ) or ( 2,3-butanediol dehydrogenase ) or ( sorbitol dehydrogenase ) or ( L-iditol 2-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__369" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Quinones__124___TO___124__Reduced__45__Quinones__124___COF_RXN" name="|Quinones|_TO_|Reduced-Quinones|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Reduced__45__Quinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__TYROSINE__45__PHOSPHATASE__45__RXN" name="Protein-tyrosine-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4349 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein-tyrosine-phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.48</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALGLDAPAALIG__45__RXN" name="UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1559 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C1" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATE__45__1__45__EPIMERASE__45__RXN" name="Glucose-6 phosphate 1-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__3__45__RXN" name="Glucan 1,4-&amp;alpha;-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4205 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucoamylase, (GLUCAN 1,4-ALPHA-GLUCOSIDASE) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__363" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2009 ) or ( mll3190 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine-uridine preferring nucleoside hydrolase ) or ( nucleoside hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4641" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4770_murQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylmuramic acid-6-phosphate etherase )</html:p>
<html:p>SUBSYSTEM: 1,6-anhydro-N-acetylmuramic acid recycling</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__366" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2009 ) or ( mll3190 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine-uridine preferring nucleoside hydrolase ) or ( nucleoside hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSAAMINOTRANS__45__RXN" name="Glutamate-1-semialdehyde 2,1-aminomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5149 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminotransferase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTAMATE__45__1__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2043" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2086 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cellulase )</html:p>
<html:p>SUBSYSTEM: cellulose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__40__1__45__4__45____38__amp__59__amp__59__beta__59____45__D__45__glucan__41____40__m__43__n__41__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__40__1__45__4__45____38__amp__59__amp__59__beta__59____45__D__45__glucan__41____40__n__41__" stoichiometry="1"/>
      <speciesReference species="__40__1__45__4__45____38__amp__59__amp__59__beta__59____45__D__45__glucan__41____40__m__41__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERKIN__45__RXN" name="Homoserine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7503_thrB ) or ( mlr7168 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Homoserine kinase (HSK) (HK)//Homoserine kinase ) or ( homoserine kinase )</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.39</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1405_ilvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ketol-acid reductoisomerase (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase)//Ketol-acid reductoisomerase )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDHMSARC__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2289 ) or ( mll1128 ) or ( mll1129 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbon-monoxide dehydrogenase small chain ) or ( carbon-monoxide dehydrogenase large subunit ) or ( carbon-monoxide dehydrogenase small subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLULOSE__45__REDUCTASE__45__RXN" name="D-xylulose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4915 ) or ( mll4921 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative D-xylulose reductase (Xylitol dehydrogenase) (XDH)//D-xylulose reductase ) or ( sorbitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__THREO__45__ALDOSE__45__1__45__DEHYDROGENASE__45__RXN" name="D-threo-aldose 1-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3332 ) or ( mll8482 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxidoreductase (D-threo-aldose 1-dehydrogenase )//D-threo-aldose 1-dehydrogenase ) or ( similar to D-threo-aldose 1-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.122</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8548" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8549" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICONUCADENYLYLTRAN__45__RXN" name="Nicotinate-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4008_nadD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinic acid mononucleotide adenyltransferase//NICONUCADENYLYLTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__57__45__RXN" name="aromatic-amino-acid transaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0405 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aromatic__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aromatic__45__Oxoacids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__1__46__11__45__RXN" name="Glutamate--putrescine ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6521 ) or ( mll5148 ) or ( mll7254 ) or ( mll4187 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamine synthetase ) or ( probable glutamine synthetase ) or ( glutamine synthetase ) or ( glutamine synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__GLUTAMYL__45__PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__133__45__RXN" name="Precorrin-4 C11-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1385 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 3 methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.133</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1241" name="coniferyl-aldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4051 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.68</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CONIFERYL__45__ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYRIBONUCSYN__45__RXN" name="Phosphoribosylamine--glycine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7447_purD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoribosylamine--glycine ligase (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase)//GLYRIBONUCSYN-RXN//Phosphoribosylamine--glycine ligase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFATE__45__ADENYLYLTRANS__45__RXN" name="Sulfate adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7576 ) or ( mlr7575 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein ) or ( sulfate adenylyltransferase subunit 2 )</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: sulfate reduction II (assimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: sulfite oxidation III</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.4</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6268" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis III (plants)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETAINE__45__ALDEHYDE__45__HYDRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__5__46__1__46__2__45__RXN" name="3-carboxy-cis,cis-muconate cycloisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7211 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-carboxy-cis,cis-muconate cycloisomerase )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__245" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7737" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONATE__45__2__45__DEHYDROGENASE__45__RXN" name="Gluconate 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3056 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gluconate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRIBFAICARPISOM__45__RXN" name="N-(5&apos;-phospho-D-ribosylformimino)-5-amino-1-(5&apos;&apos;-phosphoribosyl)-4- imidazole carboxamide isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5014_hisA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase)//PRIBFAICARPISOM-RXN )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4621" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7241_anmK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Anhydro-N-acetylmuramic acid kinase (AnhMurNAc kinase) )</html:p>
<html:p>SUBSYSTEM: 1,6-anhydro-N-acetylmuramic acid recycling</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__882" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLASPARTATE__45__AMMONIA__45__LYASE__45__RXN" name="Methylaspartate ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6095 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methylaspartate ammonia-lyase )</html:p>
<html:p>SUBSYSTEM: glutamate degradation VI (to pyruvate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.2</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__THREO__45__3__45__METHYL__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MESACONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALTRODEHYDRAT__45__RXN" name="Altronate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3330 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydratase (D-GALACTARATE DEHYDRATASE, altronate dehydratase ) )</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: D-galacturonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.7</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALTRONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7913 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.5</html:p>
<html:p>SIDE: GLYCEROL__45__3P</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLPROLYL__45__ISOMERASE__45__RXN" name="Peptidylprolyl isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0728 ) or ( mll1054_tig ) or ( mll0727 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptidyl prolyl cis-trans isomerase ) or ( Trigger factor (TF) ) or ( peptidyl prolyl cis-trans isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8625" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDGALDOL__45__RXN" name="2-dehydro-3-deoxyglucarate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5426 ) or ( mlr0073 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-2-oxovalerate aldolase ) or ( 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase )</html:p>
<html:p>SUBSYSTEM: D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.20</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__KETO__45__4__45__DEOXY__45__D__45__GLUCARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSINE__45__23__45__AMINOMUTASE__45__RXN" name="Lysine 2,3-aminomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5971 ) or ( mll1971 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-lysine 2,3-aminomutase ) or ( L-lysine 2,3-aminomutase )</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__233" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KYNURENINASE__45__RXN" name="Kynureninase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0621 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable kynureninase (kyurenine hydrolase) )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation I (via anthranilate)</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__130__45__RXN" name="Precorrin-2 C20-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1380 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin-2 C(20)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.130</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__642" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONOSYLTRANSFERASE__45__RXN" name="UDP-glucuronosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4194 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to macrolide glycosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
      <speciesReference species="__124__Non__45__Glucur__45__Glucuronoside__45__Acceptors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Beta__45__D__45__Glucuronides__124__" stoichiometry="1"/>
      <speciesReference species="__124__Glucuronosylated__45__Glucuronoside__45__Acceptors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__2__46__3__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4199 ) or ( mlr5629 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase ) or ( probable 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__3__45__HYDROXYBUTANOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0872 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione dependent formaldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.284</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GART__45__RXN" name="Phosphoribosylglycinamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7961 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.2</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOSEPHOSPHO__45__RXN" name="transport of fructose by PTS" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3194 ) or ( mll3613 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphotransferase system enzyme II ) or ( phosphotransferase system enzyme II, BC COMPONENT )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU1P" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__113__45__RXN" name="Site-specific DNA-methyltransferase (cytosine-N4-specific)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9056 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.113</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__Cytosine__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__DNA__45__N4__45__Methylcytosine__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HALOALKANE__45__DEHALOGENASE__45__RXN" name="Haloalkane dehalogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2612 ) or ( mlr5354_dhaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxymuconic semialdehyde hydrolase ) or ( Haloalkane dehalogenase//Haloalkane dehalogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__Haloalkanes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Primary__45__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Halides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXY__45__KYNURENINASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0621 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable kynureninase (kyurenine hydrolase) )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__8__45__RXN" name="Dimethylaniline monooxygenase (N-oxide forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7934 ) or ( mlr4561 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to dimethylaniline monooxygenase ) or ( dimethylaniline monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NN__45__DIMETHYLANILINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NN__45__DIMETHYLANILINE__45__N__45__OXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAPOXNPHOSPHN__45__RXN" name="Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3750 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyceraldehyde-3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R12__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8483 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phospho-3-hexuloisomerase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__26" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD_TO_FADH2_COF_RXN" name="FAD_TO_FADH2_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FADH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.22</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNONDEHYDRAT__45__RXN" name="Mannonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6866_uxuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mannonate dehydratase (D-mannonate hydrolase)//MANNONDEHYDRAT-RXN//Mannonate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__MANNONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREODEHYD__45__RXN" name="L-threonine 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8299_tdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-threonine 3-dehydrogenase//THREODEHYD-RXN//L-threonine 3-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: threonine degradation II</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.103</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__274__45__RXN" name="2,5-didehydrogluconate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1906 ) or ( mll2491 ) or ( mlr2172 ) or ( mlr5327 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable oxidoreductase ) or ( aryl-alcohol dehydrogenase ) or ( probable oxidoreductase ) or ( probable oxidoreductase )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.274</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_25__45__DIDEHYDRO__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHEAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5786_hisC3 ) or ( mll3536_hisC2 ) or ( mll0405 ) or ( mll7737 ) or ( mll7105_hisC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Histidinol-phosphate aminotransferase 3 (Imidazole acetol-phosphate transaminase 3) ) or ( Histidinol-phosphate aminotransferase 2 (Imidazole acetol-phosphate transaminase 2) ) or ( aromatic amino acid aminotransferase ) or ( histidinol-phosphate aminotransferase ) or ( Histidinol-phosphate aminotransferase 1 (Imidazole acetol-phosphate transaminase 1) )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation III</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9226_argH2 ) or ( mlr3506_argH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Argininosuccinate lyase 2 (Arginosuccinase 2) (ASAL 2)//Argininosuccinate lyase ) or ( Argininosuccinate lyase 1 (Arginosuccinase 1) (ASAL 1)//Argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERPHOSPHA__45__RXN" name="Phosphoserine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1449 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable phosphoserine phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phosphoserines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Serines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATEMUT__45__RXN" name="Chorismate mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4380 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chorismate mutase )</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4OHBENZOATE__45__OCTAPRENYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7442_ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALADENOSYLTRANS__45__RXN" name="Cob(I)alamin adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1306 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)alamin adenosyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COB__45__I__45__ALAMIN" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16ALDOLASE__45__RXN" name="Fructose-bisphosphate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7221 ) or ( mll7273 ) or ( mlr3754 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PUTATIVE ALDOLASE ) or ( fructose-1,6-bisphosphate aldolase ) or ( fructose-bisphosphate aldolase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7607" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1080_surE ) or ( mlr3017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase)//5&apos;-NUCLEOTID-RXN//5&apos;-nucleotidase ) or ( 5&apos;-nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LONG__45__CHAIN__45__ACYL__45__COA__45__DEHYDROGENASE__45__RXN" name="long-chain acyl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5626 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.13</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATE__45__RACEMASE__45__RXN" name="Aspartate racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4070 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate racemase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__302" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7609" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1080_surE ) or ( mlr3017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase)//5&apos;-NUCLEOTID-RXN//5&apos;-nucleotidase ) or ( 5&apos;-nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDAZOLONEPROPIONASE__45__RXN" name="Imidazolonepropionase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8319_hutI ) or ( mlr9376 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Imidazolonepropionase (Imidazolone-5-propionate hydrolase)//Imidazolonepropionase ) or ( hydrolase )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.7</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMIMINO__45__L__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPHOSPHOR__45__RXN" name="Guanosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0765 ) or ( mlr3159 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase ) or ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.15</html:p>
<html:p>SIDE: RIBOSE__45__1P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYL__45__PHOSPHATASE__45__RXN" name="aryldialkyl phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7664 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to resiniferotoxin-binding, phosphotriesterase-related protein )</html:p>
<html:p>SUBSYSTEM: parathion degradation</html:p>
<html:p>SUBSYSTEM: superpathway of parathion degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1826" name="starch phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7586 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__662" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2491 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: p-cymene degradation to p-cumate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1002" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1003" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMACTRAN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1969 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLSPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4366_argG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Argininosuccinate synthase (Citrulline--aspartate ligase)//ARGSUCCINSYN-RXN//Argininosuccinate synthase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXBUTYRYL__45__COA__45__DEHYDRATASE__45__RXN" name="3-hydroxybutyryl-CoA dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3048 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydratase )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate I</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.55</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__DEHYDRATASE__45__RXN" name="3-dehydroquinate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0207_aroQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-dehydroquinate dehydratase (3-dehydroquinase) (Type II DHQase)//3-dehydroquinate dehydratase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZYL__45__ALC__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2491 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STREPTOMYCIN__45__3__45__KINASE__45__RXN" name="Streptomycin 3&apos;&apos;-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8451 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( streptomycin phosphotransferase, streptomycin-resistance )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.87</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="STREPTOMYCIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__512" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTOX__45__RXN" name="Dihydroorotate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5681 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotate dehydrogenase 2 )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINEPHEN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6250_tynA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyramine oxidase//AMACETOXID-RXN//AMINEOXID-RXN//AMINEPHEN-RXN )</html:p>
<html:p>SUBSYSTEM: phenylethylamine degradation</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLETHYLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALAMINSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1388_cobS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cobalamin synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.26</html:p>
<html:p>SIDE: GMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__RIBAZOLE" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7614" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0619 ) or ( mlr4763 ) or ( mll6983 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable acid-CoA ligase ) or ( malonyl-CoA synthase ) or ( similar to coenzyme a synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.26</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="O__45__SUCCINYLBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6972" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLMETHANOFURAN__45__DEHYDROGENASE__45__RXN" name="Formylmethanofuran dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7310 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formyl-methanofuran dehydrogenase subunit C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Formyl__45__methanofurans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Methanofurans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__79__45__RXN" name="cyclopropane-fatty-acyl-phospholipid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0368 ) or ( mll4091 ) or ( mll7842 ) or ( mlr8091 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyclopropane-fatty-acyl-phospholipid synthase ) or ( fatty acid synthase, cyclopropane-fatty-acyl-phospholipid synthase ) or ( cyclopropane-fatty-acyl-phospholipid synthase ) or ( cyclopropane-fatty-acyl-phospholipid synthase )</html:p>
<html:p>SUBSYSTEM: cyclopropane fatty acid (CFA) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.79</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phospholipid__45__Olefinic__45__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Phospholipid__45__Cyclopropane__45__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHBUTYRYL__45__COA__45__EPIM__45__RXN" name="3-hydroxybutyryl-CoA epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4199 ) or ( mlr5629 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase ) or ( probable 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSALDOL__45__RXN" name="Transaldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4072_tal )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Probable transaldolase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPDEHYDRHAMEPIM__45__RXN" name="dTDP-4-dehydrorhamnose 3,5-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7551 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-6-deoxy-D-glucose-3,5-epimerase )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCSEMIALDDEHYDROG__45__RXN" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4198 ) or ( mlr6098 ) or ( mll5719 ) or ( mll1168 ) or ( mll7128 ) or ( mll7043 ) or ( mll5809 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( succinate-semialdehyde dehydrogenase ) or ( succinate-semialdehyde dehydrogenase ) or ( succinic semialdehyde dehydrogenase ) or ( succinic semialdehyde dehydrogenase ) or ( succinic semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPH_TO_NADP_COF_RXN" name="NADPH_TO_NADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5076 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthase (folC) )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOGLUCOKINASE__45__RXN" name="Phosphoglucokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4209 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to phosphate glucokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE__45__16__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PABSYNMULTI__45__RXN" name="synthesis of p-aminobenzoic acid" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( para-aminobenzoate synthase component I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__77__45__RXN" name="Protein-L-isoaspartate(D-aspartate) O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2502 ) or ( mll1078_pcm ) or ( mll1108 ) or ( mll2628 ) or ( RHILO0362 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable O-methyltransferase ) or ( protein-L-isoaspartate O-methyltransferase//2.1.1.77-RXN ) or ( protein-L-isoaspartate O-methyltransferase ) or ( protein-L-isoaspartate O-methyltransferase ) or ( putative Protein-L-isoaspartate(D-aspartate) O-methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.77</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOASPARTATES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CELLULOSE__45__SYNTHASE__45__UDP__45__FORMING__45__RXN" name="Cellulose synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7873 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to cellulose synthase )</html:p>
<html:p>SUBSYSTEM: cellulose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.12</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACYLMANNOSAMINE__45__KINASE__45__RXN" name="N-acylmannosamine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7234 ) or ( mlr3412 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose kinase ) or ( glucokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.60</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1109" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__841" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAMPYR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3876 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3OH__45__4P__45__OH__45__ALPHA__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHORYL__45__RXN" name="Phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7586 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDO__45__8PSYNTH__45__RXN" name="2-dehydro-3-deoxyphosphooctonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0374_kdsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-dehydro-3-deoxyphosphooctonate aldolase (Phospho-2- dehydro-3-deoxyoctonate aldolase) (3-deoxy-D-manno-octulosonic acid 8- phosphate synthetase) (KDO-8-phosphate synthetase) (KDO 8-P synthase) (KDOPS)//KDO-8PSYNTH-RXN )</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.55</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARABINOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO__45__8P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__DEHYDRATASE__45__RXN" name="Glycerol dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6722 ) or ( mll6721 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol dehydratase large subunit ) or ( glycerol dehydratase small subunit )</html:p>
<html:p>SUBSYSTEM: glycerol degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.30</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYPROPANAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM2__45__RXN" name="Cytidine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3158 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP_TO_GTP_COF_RXN" name="GDP_TO_GTP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1015 ) or ( mll2867 ) or ( mll7045 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2664 ) or ( mlr7635 ) or ( mll9205 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase ) or ( aminotransferase ) or ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREDEHYD__45__RXN" name="Threonine dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7138 ) or ( mlr3510 ) or ( mll4597 ) or ( mlr0162 ) or ( mll0670 ) or ( mll7611 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine dehydratase ) or ( threonine dehydratase ) or ( putative threonine dehydratase ) or ( threonine dehydratase ) or ( L-serine dehydratase ) or ( serine/threonine dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO___124__Fatty__45__Acyl__45__CoA__124___COF_RXN" name="CO-A_TO_|Fatty-Acyl-CoA|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHUROPORDEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3232 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( siroheme synthetase [Rhizobium leguminosarum )</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.76</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTPDECARB__45__RXN" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4751_pyrF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Orotidine 5&apos;-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase)//OROTPDECARB-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.23</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXAL__45__4__45__DEHYDROGENASE__45__RXN" name="Pyridoxal 4-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8482 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to D-threo-aldose 1-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: vitamin B6 degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.107</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__375" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2023" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2824_trmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase//tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__THIOURIDINE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRILE__45__HYDRATASE__45__RXN" name="Nitrile hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1423 ) or ( mll1425 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrile hydratase beta subunit ) or ( nitrile hydratase alpha subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nitriles__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROT__45__RXN" name="Dihydroorotase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4451 ) or ( mlr7790 ) or ( mlr0687 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotase ) or ( dihydroorotase ) or ( dihydroorotase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5521 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROG__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0710_glpD ) or ( mlr4225_gpsA ) or ( mlr7270 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase//GLYC3PDEHYDROG-RXN ) or ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN ) or ( glycerol-3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donors reaction list</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)-- electron donors reaction list</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERALDEHYDE__45__DEHYDRO__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7045 ) or ( mll2867 ) or ( mll1015 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2602" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5585_mutM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (DNA-(apurinic or apyrimidinic site) lyase mutM) (AP lyase mutM)//RXN0-2602//DNA-(apurinic or apyrimidinic site) lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.23</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Damaged__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__AP__45__Site__45__Created__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MORPHINE__45__6__45__DEHYDROGENASE__45__RXN" name="Morphine 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2211 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( morphinone reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.218</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MORPHINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MORPHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHD__45__RXN" name="Choline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7609_betA ) or ( mlr2604 ) or ( mlr6656 ) or ( mll3225 ) or ( mlr6792 ) or ( mlr6655 ) or ( mlr3058 ) or ( mll1008 ) or ( mlr7098 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Choline dehydrogenase (CHD) (CDH)//CHD-RXN//Choline dehydrogenase ) or ( alcohol dehydrogenase ) or ( dehydrogenase ) or ( dehydrogenase (polyethylene glycol dehydrogenase, alcohol dehydrogenase, L-sorbose dehydrogenase) ) or ( probable dehydrogenase ) or ( similar to dehydrogenase subunit ) or ( dehydrogenase, (L-sorbose dehydrogenase, GMC oxidoreductase, glycol dehydrogenase, alcohol dehydrogenase) ) or ( probable dehydrogenase ) or ( GMC-type oxidoreductase )</html:p>
<html:p>SUBSYSTEM: choline degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis I (Gram-negative bacteria)</html:p>
<html:p>SUBSYSTEM: choline-O-sulfate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLPHOSPHATASE__45__RXN" name="Acylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7735 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acylphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acyl__45__Phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__901" name="Xanthine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1927 ) or ( mlr5134 ) or ( mll2287 ) or ( mlr5135 ) or ( mlr1703 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable oxidoreductase ) or ( xanthine dehydrogenase, xdhA ) or ( 4-Hydroxybenzoyl-CoA reductase alpha-subunit ) or ( xanthine dehydrogenase, xdhB ) or ( probable dehydrogenase )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2606" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5510_recR ) or ( mlr7769_recO ) or ( mll5578_recF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Recombination protein recR ) or ( DNA repair protein recO (Recombination protein O) ) or ( DNA replication and repair protein recF )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Unstable__45__RecA__45__Filament__45__DNA__45__Complex__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Stabilized__45__RecA__45__Filament__45__DNA__45__Complex__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R222__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7045 ) or ( mll2867 ) or ( mll1015 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: octane oxidation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__371" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOCATECHUATE__45__3__45__4__45__DIOXYGENASE__45__RXN" name="Protocatechuate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7208 ) or ( mlr7210 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protocatechuate 3,4-dioxygenase beta chain ) or ( protocatechuate 3,4-dioxygenase alpha chain )</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__183" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__184" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__54__45__RXN" name="Precorrin-6X reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1382 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cobalt-precorrin-6x reductase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.54</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__675" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__679" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__SYN__45__RXN" name="glutathione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4735_gshB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutathione synthetase (Glutathione synthase) (GSH synthetase) (GSH-S) (GSHase)//GLUTATHIONE-SYN-RXN//Glutathione synthase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7644" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7108 ) or ( mll5168 ) or ( mll4921 ) or ( mlr3340 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase ) or ( 2,3-butanediol dehydrogenase ) or ( sorbitol dehydrogenase ) or ( L-iditol 2-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: sorbitol utilization</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALAMIN5PSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1388_cobS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cobalamin synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.26</html:p>
<html:p>SIDE: GMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__RIBAZOLE__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__NUCLEOTID__45__RXN" name="3&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0366_cpdB ) or ( mll1080_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional 2&apos;,3&apos;-cyclic nucleotide 2&apos;-phosphodiesterase/3&apos;-nucleotidase periplasmic precursor protein//3-NUCLEOTID-RXN//CYCPHOSDIESTER-RXN//3&apos;-nucleotidase ) or ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase)//5&apos;-NUCLEOTID-RXN//5&apos;-nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLAMINE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Arylamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4870 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylamine N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.5</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLARYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEHYDROG__45__RXN" name="Homoserine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0934 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoserine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__39__45__RXN" name="Malate dehydrogenase (decarboxylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0809 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malic enzyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.39</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALA__45__GLU__45__LIG__45__RXN" name="UDP-N-acetylmuramoylalanine--D-glutamate ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1557_murD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanine--D-glutamate ligase (UDP-N- acetylmuramoyl-L-alanyl-D-glutamate synthetase) (D-glutamic acid- adding enzyme)//UDP-NACMURALA-GLU-LIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__ACETYLMURAMOYL__45__ALA" stoichiometry="1"/>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLALANINE__45__4__45__MONOOXYGENASE__45__RXN" name="Phenylalanine 4-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4831_phhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phenylalanine-4-hydroxylase (PAH) (Phe-4- monooxygenase) )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.1</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITLY__45__RXN" name="Citrate lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0906 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( citrate lyase beta chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATESYN__45__RXN" name="Thymidylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1467_thyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thymidylate synthase (TS) (TSase)//THYMIDYLATESYN-RXN//Thymidylate synthase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.45</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: DIHYDROFOLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLULOKIN__45__RXN" name="Xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7268 ) or ( mlr5033 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylulose kinase ) or ( xylulokinase )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>SUBSYSTEM: xylose degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCULOKIN__45__RXN" name="L-fuculokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5701 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to L-fuculokinase )</html:p>
<html:p>SUBSYSTEM: fucose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.51</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__FUCULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUCULOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOESTER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4347 ) or ( mll4250 ) or ( mlr4383 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase ) or ( acyl-CoA thioesterase II ) or ( acyl-CoA thioesterase )</html:p>
<html:p>SUBSYSTEM: acyl-CoA hydrolysis</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Saturated__45__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1041" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0404_mazG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside triphosphate pyrophosphohydrolase//RXN0-1041 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__280" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5216_ssuD1 ) or ( mll2278 ) or ( mlr5218 ) or ( mlr7299 ) or ( mll4558_ssuD2 ) or ( mll5137 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Alkanesulfonate monooxygenase 1 (FMNH2-dependent aliphatic sulfonate monooxygenase 1)//Alkanesulfonate monooxygenase ) or ( nitrilotriacetate monooxygenase ) or ( sulfonate monooxygenase ) or ( nitrilotriacetate monooxygenase component A ) or ( Alkanesulfonate monooxygenase 2 (FMNH2-dependent aliphatic sulfonate monooxygenase 2)//Alkanesulfonate monooxygenase ) or ( nitrilotriacetate monooxygenase component A )</html:p>
<html:p>SUBSYSTEM: two-component alkanesulfonate monooxygenase</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.5</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alkanesulfonates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R__45__6__45__HYDROXYNICOTINE__45__OXIDASE__45__RXN" name="(R)-6-hydroxynicotine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6875 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__6__45__HYDROXYNICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2043" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4180 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-ketoadipyl CoA thiolase )</html:p>
<html:p>SUBSYSTEM: phenylacetate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__DIHYDRODIOL__45__DERIV__45__PHEAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXYADIPYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOKINASE__45__RXN" name="Fructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7580 ) or ( mll7216 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructokinase ) or ( fructokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7657" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3070 ) or ( mll5720 ) or ( mlr1913 ) or ( mlr1136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase) ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7000" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOBUTANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7917_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DADP_TO_DATP_COF_RXN" name="DADP_TO_DATP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="DADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOINDEHYDROG__45__A__45__RXN" name="Acetoin dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3629 ) or ( mll3628 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetoin dehydrogenase (TPP-dependent) alpha chain ) or ( acetoin dehydrogenase (TPP-dependent) beta chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEHYDDEOXGALACTKIN__45__RXN" name="2-dehydro-3-deoxygalactonokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4742 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-dehydro-3-deoxygalactonate kinase )</html:p>
<html:p>SUBSYSTEM: D-galactonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.58</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GALACTONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDRO__45__DEOXY__45__GALACTONATE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__3__46__20__45__RXN" name="ADP-glyceromanno-heptose 6-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2565_hldD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-L-glycero-D-manno-heptose-6-epimerase (ADP-L- glycero-beta-D-manno-heptose-6-epimerase) (ADP-glyceromanno-heptose 6- epimerase) (ADP-hep 6-epimerase) (AGME) )</html:p>
<html:p>SUBSYSTEM: ADP-L-glycero-&amp;beta;-D-manno-heptose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__D__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2625" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5328_mutS ) or ( mll8278_mutL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA mismatch repair protein mutS ) or ( DNA mismatch repair protein mutL )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8199" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8200" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHLBXANAU__45__RXN" name="2-haloacid dehalogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4579 ) or ( mlr7041 ) or ( mll7634 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-haloalkanoic acid dehalogenase ) or ( similar to haloalkanoic acid dehalogenase ) or ( 2-haloacid halidohydrolase Iva )</html:p>
<html:p>SUBSYSTEM: 1,2-dichloroethane degradation pathway</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROACETIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6250_tynA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyramine oxidase//AMACETOXID-RXN//AMINEOXID-RXN//AMINEPHEN-RXN )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VI (via tryptamine)</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__SYNTHASE__45__RXN" name="3-dehydroquinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3571_aroB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-dehydroquinate synthase//3-DEHYDROQUINATE-SYNTHASE-RXN//3-dehydroquinate synthase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2621" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2631_uvrB ) or ( mlr0750_uvrA ) or ( mlr7912_uvrC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UvrABC system protein B (Protein uvrB) (Excinuclease ABC subunit B) ) or ( UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A) ) or ( UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.25-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8180" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8534" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2624" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3898_ruvA ) or ( mll3895_ruvB ) or ( mll3901_ruvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Holliday junction ATP-dependent DNA helicase ruvA ) or ( Holliday junction ATP-dependent DNA helicase ruvB ) or ( Crossover junction endodeoxyribonuclease ruvC (Holliday junction nuclease ruvC) (Holliday junction resolvase ruvC)//RXN0-2624//Crossover junction endodeoxyribonuclease )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.22.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__Combined__45__With__45__Exogenous__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Resolution__45__of__45__Recombinational__45__Junction__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRTRANS__45__RXN" name="Anthranilate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0614_trpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Anthranilate phosphoribosyltransferase//Anthranilate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2081" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5614 ) or ( mlr2864 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DMSO reductase chain A ) or ( nitrate reductase large subunit )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)-- electron acceptors reaction list</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.4</html:p>
<html:p>SIDE: UBIQUINOL__45__10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UBIQUINONE__45__10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
      <speciesReference species="UBIQUINOL__45__10" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__10" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TEICHOICSYN2__45__RXN" name="N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-&amp;beta;-D- mannosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6502 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative N-acetyl-mannosamine transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.187</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__D__45__GLUCOSAMINYLDIPHOSPHO__45__UNDECAPRE" stoichiometry="1"/>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__ETCETERA__45__GLUCOSAMINYLDIPHOSPHOUND" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULOSE__45__BISPHOSPHATE__45__CARBOXYLASE__45__RXN" name="Ribulose-bisphosphate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7006 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribulose bisphosphate carboxylase, large subunit )</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.39</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__RIBULOSE__45__15__45__P2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCINYLBENZOATE__45__COA__45__LIG__45__RXN" name="O-succinylbenzoate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0619 ) or ( mlr4763 ) or ( mll6983 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable acid-CoA ligase ) or ( malonyl-CoA synthase ) or ( similar to coenzyme a synthetase )</html:p>
<html:p>SUBSYSTEM: menaquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.26</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__SUCCINYLBENZOATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYLBENZOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__143__45__RXN" name="24-methylenesterol C-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1644 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable sterol methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.143</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4101" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4124" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYBENZOATE__45__3__45__MONOOXYGENASE__45__RXN" name="4-hydroxybenzoate 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7212 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybenzoate 3-monooxygenase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7669" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7587_glgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,4-alpha-glucan-branching enzyme (Glycogen-branching enzyme) (BE) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl- transferase)//GLYCOGEN-BRANCH-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOINDEHYDROG__45__RXN" name="acetoin dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3629 ) or ( mll3628 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetoin dehydrogenase (TPP-dependent) alpha chain ) or ( acetoin dehydrogenase (TPP-dependent) beta chain )</html:p>
<html:p>SUBSYSTEM: butanediol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.5</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTSEMIALDEHYDROG__45__RXN" name="Glutamate-5-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4009_proA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gamma-glutamyl phosphate reductase (GPR) (Glutamate-5- semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase)//GLUTSEMIALDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1461" name="Coproporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6633 ) or ( mlr4627 ) or ( mlr2722 ) or ( mll6408 ) or ( mll5815 ) or ( mlr6390 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( coproporphyrinogen III oxidase ) or ( coproporphyrinogen III oxidase ) or ( coproporphyrinogen III oxidase ) or ( coproporphyrinogen III oxidase ) or ( coproporphyrinogen III oxidase ) or ( coproporphyrinogen III oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__2__46__10__45__RXN" name="Phosphoglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3879_glmM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoglucosamine mutase//5.4.2.10-RXN//Phosphoglucosamine mutase )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSAMINE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSMANMUT__45__RXN" name="Phosphomannomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7567 ) or ( mlr5801 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nodulation protein noeK, phosphomannomutase ) or ( NoeK, phosphomannomutase (PMM) )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAZIN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4882 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrazinamidase/nicotinamidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRAZINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRAZINOIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMIDASE__45__RXN" name="Amidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7070 ) or ( mll3370 ) or ( mlr9017 ) or ( mlr2310 ) or ( mlr5350 ) or ( mlr2975 ) or ( mlr3187 ) or ( mlr0229 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidase ) or ( amidase ) or ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( amidase ) or ( probable amidase ) or ( amidase ) or ( amidase ) or ( amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Monocarboxylic__45__Acid__45__Amides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Monocarboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__37" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7045 ) or ( mll2867 ) or ( mll1015 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__30" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__35" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__262" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0547_mobA ) or ( mlr0548 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Probable molybdopterin-guanine dinucleotide biosynthesis protein A ) or ( molybdopterin-guanine dinucleotide biosynthesis protein B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="CPD__45__4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__582" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__34" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5015 ) or ( mll6778 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase ) or ( arginase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7682" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1927 ) or ( mll2287 ) or ( mlr5135 ) or ( mlr1703 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable oxidoreductase ) or ( 4-Hydroxybenzoyl-CoA reductase alpha-subunit ) or ( xanthine dehydrogenase, xdhB ) or ( probable dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOATE__45__DEIMINASE__45__RXN" name="Allantoate deiminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7658 ) or ( mll1631 ) or ( mlr7938 ) or ( mlr0967 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allantoate amidohydrolase ) or ( allantoate amidohydrolase ) or ( allantoate amidohydrolase ) or ( allantoate amidohydrolase )</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate II (ammonia producing)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.9</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__598" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPRIBOSYLTRAN__45__RXN" name="Adenine phosphoribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2701_apt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenine phosphoribosyltransferase (APRT)//ADENPRIBOSYLTRAN-RXN//Adenine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.7</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPRIBOSYLTRAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0141_gpt ) or ( mll3520 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Xanthine phosphoribosyltransferase (Xanthine-guanine phosphoribosyltransferase) (XGPRT)//XANPRIBOSYLTRAN-RXN//Xanthine phosphoribosyltransferase ) or ( hypoxanthine-guanine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DMBPPRIBOSYLTRANS__45__RXN" name="Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1389_cobT ) or ( mll0563_cobT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (N(1)-alpha-phosphoribosyltransferase)//DMBPPRIBOSYLTRANS-RXN//Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase ) or ( nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.21</html:p>
<html:p>SIDE: NIACINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
      <speciesReference species="DIMETHYLBENZIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__RIBAZOLE__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINALOOL__45__8__45__MONOOXYGENASE__45__RXN" name="Linalool 8-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8468 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P-450 hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.28</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_37__45__DIMETHYLOCTA__45__16__45__DIEN__45__3__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__37__45__DIMETHYLOCTA__45__16__45__DIEN__45__38__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__600" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1975 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable cinnamoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.219</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__474" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__590" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7164 ) or ( mll4981 ) or ( mll1433 ) or ( mll1432_ilvH ) or ( mlr6648 ) or ( mlr1615 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetolactate synthase ) or ( acetolactate synthase, iolD ) or ( acetolactate synthase 3 catalytic subunit ) or ( acetolactate synthase 3 regulatory subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN ) or ( acetolactate synthase, large subunit ) or ( acetolactate synthase 2 catalytic subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNN__45__404" name="indole acetamide hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7070 ) or ( mll3370 ) or ( mlr9017 ) or ( mlr2310 ) or ( mlr5350 ) or ( mlr2975 ) or ( mlr3187 ) or ( mlr0229 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidase ) or ( amidase ) or ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( amidase ) or ( probable amidase ) or ( amidase ) or ( amidase ) or ( amidase )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__237" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE_TO_L__45__ALPHA__45__ALANINE_COF_RXN" name="PYRUVATE_TO_L-ALPHA-ALANINE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Homoserine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3538_metX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Homoserine O-acetyltransferase (Homoserine O-trans- acetylase) (Homoserine transacetylase) (HTA)//Homoserine O-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: homocysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.31</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERCURY__45__II__45__REDUCTASE__45__RXN" name="Mercury (II) reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2769 ) or ( mll5241 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mercuric reductase ) or ( mercuric reductase )</html:p>
<html:p>SUBSYSTEM: phenylmercury acetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.16.1.1</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HG__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HG0" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBPSYN__45__RXN" name="carbamoyl-phosphate synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2489_carA ) or ( mlr2517_carB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Carbamoyl-phosphate synthase small chain (Carbamoyl- phosphate synthetase glutamine chain)//CARBPSYN-RXN ) or ( Carbamoyl-phosphate synthase large chain (Carbamoyl- phosphate synthetase ammonia chain)//CARBPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FARNESYLTRANSTRANSFERASE__45__RXN" name="Farnesyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7426 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl-diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: geranylgeranyldiphosphate biosynthesis II (plastidic)</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.29</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__68__45__RXN" name="Isoamylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7591 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycosyl hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.68</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__6__45__alpha__45__D__45__glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__6__45__alpha__45__D__45__glucan__124__" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOHEMEFERROCHELAT__45__RXN" name="Ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3019_hemH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ferrochelatase (Protoheme ferro-lyase) (Heme synthetase)//PROTOHEMEFERROCHELAT-RXN//Ferrochelatase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDROG__45__RXN" name="Prephenate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3535 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyclohexadienyl dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__218" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7624 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-5 sterol desaturase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPISTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_572428__45__ERGOSTATRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOHMETRANS__45__RXN" name="glycine hydroxymethyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8400_glyA1 ) or ( mlr6114_glyA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine hydroxymethyltransferase 1 (Serine methylase 1) (SHMT 1) ) or ( Serine hydroxymethyltransferase 2 (Serine methylase 2) (SHMT 2) )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.1</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREONINE__45__ALDOLASE__45__RXN" name="Threonine aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6130 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-threonine aldolase )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>SIDE: ACETALD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__23__45__DIOXYGENASE__45__RXN" name="Tryptophan 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0620 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable tryptophan 2,3-dioxygenase )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: tryptophan degradation I (via anthranilate)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.11</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMYLKYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7800" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__17__46__1__46__2__45__RXN" name="4-hydroxy-3-methylbut-2-enyl diphosphate reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7502_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN//RXN0-884//4-hydroxy-3-methylbut-2-enyl diphosphate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__4__45__HYDROXY__45__3__45__METHYLBUT__45__2__45__EN__45__1__45__YL__45__DIPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__2__45__HYDROXY__45__ACID__45__OXIDASE__45__RXN" name="(S)-2-hydroxy-acid oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4732 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycolate oxidase, (S)-2-hydroxy-acid oxidase , peroxisomal//(S)-2-hydroxy-acid oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__2__45__Hydroxyacids1__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1941" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1906 ) or ( mll2491 ) or ( mlr2172 ) or ( mlr5327 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable oxidoreductase ) or ( aryl-alcohol dehydrogenase ) or ( probable oxidoreductase ) or ( probable oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.274</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHYL__45__2__45__METHYLACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHYL__45__2R__45__METHYL__45__3S__45__HYDROXYBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5289" name="2-hydroxy-3-oxopropionate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0254 ) or ( mlr1689 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable oxidoreductase ) or ( 3-hydroxyisobutyrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation (E. coli)</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.60</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THRESYN__45__RXN" name="Threonine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7517 ) or ( mll9542 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine synthase ) or ( threonine synthase homolog )</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__METHYLTHIORIBOSE__45__KINASE__45__RXN" name="5-methylthioribose kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7285_mtnK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylthioribose kinase )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.100</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__560" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOGLYCOSIDE__45__N6__45__ACETYLTRANSFERASE__45__RXN" name="Kanamycin 6&apos;-N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4309 ) or ( mll5006 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminoglycoside 6&apos;-N-acetyltransferase ) or ( aminoglycoside 6&apos;-N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.82</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4822" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N6__45__ACETYLKANAMYCIN__45__B" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3529 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable 1-acyl-SN-glycerol-3-phosphate acyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.51</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7810" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7442_ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__7109" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7105" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA__45__CARBOXYLTRANSFER__45__RXN" name="Acetyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0206 ) or ( mlr5075 ) or ( mlr3576_accA ) or ( mll0203 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA carboxylase biotin carboxyl carrier protein subunit ) or ( acetyl-CoA carboxylase subunit beta ) or ( Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (Acetyl-CoA carboxylase carboxyltransferase subunit alpha) (ACCase subunit alpha)//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055//Acetyl-CoA carboxylase ) or ( acetyl-CoA carboxylase biotin carboxylase subunit )</html:p>
<html:p>SUBSYSTEM: fatty acid biosynthesis - initial steps I</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7811" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7442_ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="_3__45__METHYL__45__1__45__246__45__TRIHYDROXYPHENYLBUTAN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7109" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7812" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7442_ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__7104" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__PRENYLPHLORISOBUTYROPHENONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2664 ) or ( mlr7635 ) or ( mll9205 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase ) or ( aminotransferase ) or ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7813" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7442_ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__PRENYLPHLORISOBUTYROPHENONE" stoichiometry="1"/>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5293" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4198 ) or ( mlr6098 ) or ( mll5719 ) or ( mll1168 ) or ( mll7128 ) or ( mll7043 ) or ( mll5809 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( succinate-semialdehyde dehydrogenase ) or ( succinate-semialdehyde dehydrogenase ) or ( succinic semialdehyde dehydrogenase ) or ( succinic semialdehyde dehydrogenase ) or ( succinic semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OPPSYN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7426 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl-diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTPRATPHYD__45__RXN" name="Phosphoribosyl-ATP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5018_hisE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoribosyl-ATP pyrophosphatase (PRA-PH) )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5467" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6501 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to mannosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
      <speciesReference species="CPD__45__5165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5469" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6501 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to mannosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5167" stoichiometry="1"/>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5168" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6501 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to mannosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.132</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__MANNOSYLCHITOBIO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5161" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5463" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6501 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to mannosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5161" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5162" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxyisobutyrate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2606 ) or ( mlr0552 ) or ( mlr1203 ) or ( mlr1689 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyisobutyrate dehydrogenase ) or ( 3-hydroxyisobutyrate dehydrogenase ) or ( 3-hydroxyisobutyrate dehydrogenase ) or ( 3-hydroxyisobutyrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.31</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BHBDCLOS__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5041 ) or ( mlr2803 ) or ( mlr5629 ) or ( mll1034 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydrogenase ) or ( 3-hydroxyacyl-CoA dehydrogenase type II//3-hydroxyacyl-CoA dehydrogenase ) or ( probable 3-hydroxyacyl-CoA dehydrogenase ) or ( 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate I</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYT__45__UBIQUINOL__45__OXID__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6849 ) or ( mlr6847 ) or ( mlr6846 ) or ( mlr6848 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome o ubiquinol oxidase subunit IV ) or ( cytochrome o ubiquinol oxidase subunit I ) or ( cytochrome o ubiquinol oxidase subunit II ) or ( cytochrome o ubiquinol oxidase subunit III )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDPHOSDEHYD__45__RXN" name="Imidazoleglycerol-phosphate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5008_hisB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Imidazoleglycerol-phosphate dehydratase (IGPD)//Imidazoleglycerol-phosphate dehydratase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TAGAALDOL__45__RXN" name="Tagatose-bisphosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3411 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tagatose-1,6-bisphosphate aldolase )</html:p>
<html:p>SUBSYSTEM: galactitol degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.40</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAGATOSE__45__1__45__6__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Aspartate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4392 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate-semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.11</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPPYPHOSKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7755 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP pyrophosphokinase )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE__45__5DP__45__3DP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLMALONYL__45__COA__45__MUT__45__RXN" name="Methylmalonyl-CoA mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7619 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonyl-CoA mutase )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Protein__45__Dithiols__124___TO___124__Protein__45__Disulfides__124___COF_RXN" name="|Protein-Dithiols|_TO_|Protein-Disulfides|_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Dithiols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LCYSDESULF__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1566 ) or ( mll4503 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine gamma-lyase ) or ( cystathionine gamma-lyase )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5470" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2557 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5168" stoichiometry="1"/>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5169" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITRATE__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Isocitrate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0036 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.41</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5471" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2557 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
      <speciesReference species="CPD__45__5169" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5170" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAPASYN__45__RXN" name="Adenosylmethionine--8-amino-7-oxononanoate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1207 ) or ( mll5828 ) or ( mll9097 ) or ( mlr5987 ) or ( mll6003 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aminotransferase ) or ( adenosylmethionine--8-amino-7-oxononanoate transaminase ) or ( adenosylmethionine--8-amino-7-oxononanoate transaminase ) or ( putative aminotransferase ) or ( similar to adenosylmethionine-8-amino-7-oxononanoate aminotransferase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.62</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_8__45__AMINO__45__7__45__OXONONANOATE" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE1EPIM__45__RXN" name="ALDOSE-1-EPIMERASE" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1167 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldose 1-epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7421" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0368 ) or ( mll4091 ) or ( mll7842 ) or ( mlr8091 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyclopropane-fatty-acyl-phospholipid synthase ) or ( fatty acid synthase, cyclopropane-fatty-acyl-phospholipid synthase ) or ( cyclopropane-fatty-acyl-phospholipid synthase ) or ( cyclopropane-fatty-acyl-phospholipid synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.79</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSTERCULIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANPRIBOSYLTRAN__45__RXN" name="Xanthine-guanine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0141_gpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Xanthine phosphoribosyltransferase (Xanthine-guanine phosphoribosyltransferase) (XGPRT)//XANPRIBOSYLTRAN-RXN//Xanthine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.22</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__1__46__6__45__RXN" name="biotin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9100 ) or ( mlr7548 ) or ( mll6007 ) or ( mll5831 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthase ) or ( probable biotin synthase ) or ( biotin synthase ) or ( biotin synthetase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: CH33ADO</html:p>
<html:p>SIDE: MET</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CPD__45__249</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__249" stoichiometry="1"/>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
      <speciesReference species="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOPRIBOTRANS__45__RXN" name="Nicotinate-nucleotide pyrophosphorylase (carboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6272 ) or ( mll9102 ) or ( mll5833 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate-nucleotide pyrophosphorylase ) or ( nicotinate-nucleotide pyrophosphorylase ) or ( nicotinate-nucleotide pyrophosphorylase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.19</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNREDUC__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8405 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( riboflavin-specific deaminase / reductase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.193</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1086" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8567" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7650" stoichiometry="1"/>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8757" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETYL__45__COA__45__REDUCTASE__45__RXN" name="Acetoacetyl-CoA reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3848 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-ketothiolase, acetoacetyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__P__45__OR__45__NOP_TO_NADH__45__P__45__OR__45__NOP_COF_RXN" name="NAD-P-OR-NOP_TO_NADH-P-OR-NOP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6454 ) or ( mlr3966 ) or ( mll2170 ) or ( mll2167 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arsenate reductase ) or ( arsenate reductase ) or ( probable arsenate reductase ) or ( arsenate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__296" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOIC__45__ACID" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__763" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__17__45__RXN" name="L-serine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0670 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-serine dehydratase )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: L-serine degradation</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAM__45__RXN" name="Phosphoserine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3876 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSGLYPHOS__45__RXN" name="Phosphoglycerate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3753_pgk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoglycerate kinase//PHOSGLYPHOS-RXN//Phosphoglycerate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7839" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3048 ) or ( mlr8392 ) or ( mll5431 ) or ( mlr7453 ) or ( mlr8461 ) or ( mll1009 ) or ( mlr1841 ) or ( mlr6976 ) or ( mll6870 ) or ( mll6015 ) or ( mlr5044 ) or ( mlr8134 ) or ( mll5584 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( p-hydroxycinnamoyl CoA hydratase/lyase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( carnitine racemase ) or ( carnitinyl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7835" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8292 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable N-methylproline demethylase (stahydrine utilization protein stcD) )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__trans__45__4__45__cis__45__dienoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7836" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable enoyl-CoA hydratase/isomerase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTPSYN__45__RXN" name="CTP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0606_pyrG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CTP synthase (UTP--ammonia ligase) (CTP synthetase)//CTPSYN-RXN//CTP synthase )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Serine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1322 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable serine-glyoxylate aminotransferase )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7838" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3048 ) or ( mlr8392 ) or ( mll5431 ) or ( mlr7453 ) or ( mlr8461 ) or ( mll1009 ) or ( mlr1841 ) or ( mlr6976 ) or ( mll6015 ) or ( mll6870 ) or ( mlr5044 ) or ( mlr8134 ) or ( mll5584 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( p-hydroxycinnamoyl CoA hydratase/lyase ) or ( enoyl-CoA hydratase ) or ( carnitine racemase ) or ( enoyl-CoA hydratase ) or ( carnitinyl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cis__45__2__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNDEACET__45__RXN" name="Acetylornithine deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7167 ) or ( mll7049 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylornithine deacetylase ) or ( acetylornithine deacetylase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROPORIIIMETHYLTRANSA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3232 ) or ( mlr1386 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( siroheme synthetase [Rhizobium leguminosarum ) or ( uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__GLN__45__RXN" name="NAD(+) synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6744_nadE ) or ( mll0818_nadE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NH(3)-dependent NAD(+) synthetase//NAD-SYNTH-NH3-RXN ) or ( NAD synthetase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UREIDOGLYCOLATE__45__HYDROLASE__45__RXN" name="Ureidoglycolate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5130_allA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ureidoglycolate hydrolase//UREIDOGLYCOLATE-HYDROLASE-RXN//Ureidoglycolate hydrolase )</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__18__45__RXN" name="&amp;beta;-alanine--pyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1632 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta alanine--pyruvate transaminase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine degradation II</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.18</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8779" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__SORBOSONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9056" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLTHFGLUSYNTH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5076 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthase (folC) )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7001" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0765 ) or ( mlr3159 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase ) or ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARSENATE" stoichiometry="1"/>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__10__46__99__46__2__45__RXN" name="Ribosyldihydronicotinamide dehydrogenase (quinone)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7814 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinone reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.99.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7229" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7230" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5234" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8400_glyA1 ) or ( mlr6114_glyA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine hydroxymethyltransferase 1 (Serine methylase 1) (SHMT 1) ) or ( Serine hydroxymethyltransferase 2 (Serine methylase 2) (SHMT 2) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLO__45__THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Acceptor__124___TO___124__Donor__45__H2__124___COF_RXN" name="|Acceptor|_TO_|Donor-H2|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMP__45__DEHYDROG__45__RXN" name="IMP dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8350 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol-5-monophosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.205</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XMPXAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1080_surE ) or ( mlr3017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase)//5&apos;-NUCLEOTID-RXN//5&apos;-nucleotidase ) or ( 5&apos;-nucleotidase )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5240" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8400_glyA1 ) or ( mlr9371_alr3 ) or ( mlr6114_glyA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine hydroxymethyltransferase 1 (Serine methylase 1) (SHMT 1) ) or ( Alanine racemase 3//Alanine racemase ) or ( Serine hydroxymethyltransferase 2 (Serine methylase 2) (SHMT 2) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINYLDIAMINOPIMTRANS__45__RXN" name="Succinyldiaminopimelate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5646_argD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine aminotransferase (ACOAT)//ACETYLORNTRANSAM-RXN )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.17</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__SUCCINYL__45__2__45__AMINO__45__6__45__KETOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__SUCCINYLLL__45__2__45__6__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8783" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4328 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gluconolactonase )</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GULONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8780" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__SORBOSONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9055" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__13__46__3__45__RXN" name="Histidine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4698 ) or ( mll8067 ) or ( mlr2741 ) or ( mlr5307 ) or ( mlr3786 ) or ( mlr5642 ) or ( mlr3659 ) or ( mlr0562 ) or ( mll4418 ) or ( mll6540 ) or ( mlr6852 ) or ( mll3725 ) or ( mll0984 ) or ( mll0767 ) or ( mlr7686 ) or ( mll5673 ) or ( mll5087 ) or ( mlr7649 ) or ( mll0989 ) or ( mll4807 ) or ( mll7700 ) or ( mll5691 ) or ( mlr7697 ) or ( mll5094 ) or ( mll9511 ) or ( mlr4459 ) or ( mll5372 ) or ( mll2385 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( two-component system histidine protein kinase (FixL like) ) or ( two-component sensor histidine kinase ) or ( two-component sensor histidine kinase ) or ( two-component, sensor histidine protein kinase ) or ( Hybrid sensory histidine kinase ) or ( phosphate regulon, two-component sensor histidine kinase, phoR ) or ( histidine protein kinase, similar to FixL ) or ( histidine kinase sensor protein ) or ( two-component sensor histidine kinase ) or ( two component histidine protein kinase ) or ( two-component, sensor histidine protein kinase ) or ( Hybrid sensory histidine kinase ) or ( two component sensor-kinase ) or ( sensor kinase ) or ( two-component system, sensor histidine kinase ) or ( two-component sensor kinase ) or ( two-component sensor histidine kinase ) or ( two component histidine sensor kinase ) or ( two component sensor-kinase ) or ( similar to histidine protein kinase sensor for nitrogen regulator II, NRII (GlnG) ) or ( two-component, sensor histidine kinase ) or ( two-component sensor histidine kinase ) or ( two-component, sensor histidine kinase ) or ( two-component sensor histidine kinase ExoS ) or ( chemotaxis histidine kinase ) or ( sensory histidine protein kinase ) or ( two-component sensor kinase ) or ( probable sensory histidine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.13.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8781" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4619 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-sorbosone dehydrogenase )</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9055" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3PGAREARR__45__RXN" name="Phosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2186 ) or ( mlr4643_gpmA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable phosphoglycerate mutase ) or ( 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (Phosphoglyceromutase) (PGAM) (BPG-dependent PGAM) (dPGM)//3PGAREARR-RXN )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSEPHOSPHA__45__RXN" name="Trehalose-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0691 ) or ( mll0690 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate phosphatase ) or ( trehalose-6-phosphate phosphatase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis II</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis III</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLGLUTPREDUCT__45__RXN" name="N-acetyl-&amp;gamma;-glutamyl-phosphate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8452_argC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (N- acetyl-glutamate semialdehyde dehydrogenase) (NAGSA dehydrogenase)//N-acetyl-gamma-glutamyl-phosphate reductase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__469" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URACIL__45__PRIBOSYLTRANS__45__RXN" name="Uracil phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3162_upp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase)//URACIL-PRIBOSYLTRANS-RXN//Uracil phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8784" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__329" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOPHOSPHORYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7586 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLTRANSFER__45__RXN" name="Amino-acid N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3461_argJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Arginine biosynthesis bifunctional protein argJ [Includes: Glutamate N-acetyltransferase (Ornithine acetyltransferase) (Ornithine transacetylase) (OATase); Amino-acid acetyltransferase (N-acetylglutamate synthase) (AGS)] [Contains: Arginine biosynthesis bifunctional protein argJ alpha chain; Arginine biosynthesis bifunctional protein argJ beta chain]//Glutamate N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPISOM__45__RXN" name="Mannose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7607 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomannose isomerase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: D-mannose degradation</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__NUCLEOTID__45__RXN" name="5&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1080_surE ) or ( mlr3017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase)//5&apos;-NUCLEOTID-RXN//5&apos;-nucleotidase ) or ( 5&apos;-nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R313__45__RXN" name="Nitrile hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1423 ) or ( mll1425 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrile hydratase beta subunit ) or ( nitrile hydratase alpha subunit )</html:p>
<html:p>SUBSYSTEM: aldoxime degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__CYANOPYRIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__REDUCT__45__NADPH__45__RXN" name="Glutathione reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0523 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione reductase )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions II</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__6__45__RXN" name="Undecaprenyl-phosphate galactosephosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8435 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable glycosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="CPD__45__191" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PCP4MONO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3850 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pentachlorophenol 4-monooxygenase; PcpB )</html:p>
<html:p>SUBSYSTEM: pentachlorophenol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PENTACHLOROPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRACHLOROHYDROQUINONE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOLATE__45__REDUCTASE__45__RXN" name="Glycolate reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5162 ) or ( mlr5574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerate dehydrogenase ) or ( 2-hydroxyacid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.26</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8400_glyA1 ) or ( mlr6114_glyA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine hydroxymethyltransferase 1 (Serine methylase 1) (SHMT 1) ) or ( Serine hydroxymethyltransferase 2 (Serine methylase 2) (SHMT 2) )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPONTPRO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45____45__OXO__45__ACID__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6714 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine-oxo-acid transaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__NAD__43____45__RXN" name="DNA ligase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9524 ) or ( mll5481 ) or ( mll1539 ) or ( mll6696 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA ligase homolog ) or ( DNA ligase ) or ( DNA ligase ) or ( similar to DNA ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1080_surE ) or ( mlr3017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase)//5&apos;-NUCLEOTID-RXN//5&apos;-nucleotidase ) or ( 5&apos;-nucleotidase )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CPD__45__558_TO_CO__45__A_COF_RXN" name="CPD-558_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CPD__45__558" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYKIN__45__RXN" name="Diacylglycerol kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0823 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diacylglycerol kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.107</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THF_TO_10__45__FORMYL__45__THF_COF_RXN" name="THF_TO_10-FORMYL-THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOSULFATE__45__SULFURTRANSFERASE__45__RXN" name="Thiosulfate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0355 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiosulfate sulfurtransferase )</html:p>
<html:p>SUBSYSTEM: thiosulfate disproportionation III (rhodanese)</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.1</html:p>
<html:p>SIDE: HCN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="1"/>
      <speciesReference species="HCN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="HSCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BTUR2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1306 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)alamin adenosyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="COBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__GENERIC__45__RXN" name="alcohol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3070 ) or ( mll5720 ) or ( mlr1913 ) or ( mlr1136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase) ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__45__Or__45__Ketones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACID__45__PHOSPHATASE__45__RXN" name="Acid phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4110 ) or ( mll4349 ) or ( mll2704 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acid phosphatase ) or ( protein-tyrosine-phosphatase ) or ( probable acid phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__SYNTHASE__45__RXN" name="Cystathionine &amp;beta;-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4505 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>SUBSYSTEM: homocysteine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.22</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISPH2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7502_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN//RXN0-884//4-hydroxy-3-methylbut-2-enyl diphosphate reductase )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__17__45__RXN" name="3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8078 ) or ( mll9676 ) or ( mll3631 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase ) or ( 3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase CpdA homolog//3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase ) or ( 3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase, cpdA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__3__45__5__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NUC__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__99__46__28__45__RXN" name="Glucose--fructose oxidoreductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7229 ) or ( mlr3046 ) or ( mlr4777 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to glucose-fructose oxidoreductase ) or ( glucose-fructose oxidoreductase ) or ( similar to glucose-fructose oxidoreductase )</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.28</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__OXOPROLINASE__45__ATP__45__HYDROLYSING__45__RXN" name="5-oxoprolinase (ATP-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1573 ) or ( mlr9030 ) or ( mlr4786 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-oxoprolinase ) or ( probable hydantoinase ) or ( N-methylhydantoinase A (mikimopine-lactam hydrogenase) )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__OXOPROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4301" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7591 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycosyl hydrolase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.68</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OXOADIPATE__45__ENOL__45__LACTONASE__45__RXN" name="3-oxoadipate enol-lactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2481 ) or ( mlr7206 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable beta-ketoadipate enol-lactone hydrolase ) or ( beta-ketoadipate enol-lactone hydrolase )</html:p>
<html:p>SUBSYSTEM: catechol degradation to &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.24</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OXOADIPATE__45__ENOL__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETO__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARTRANSFORM__45__RXN" name="Phosphoribosylaminoimidazolecarboxamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4101_purH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase); IMP cyclohydrolase (Inosinicase) (IMP synthetase) (ATIC)]//AICARTRANSFORM-RXN//IMPCYCLOHYDROLASE-RXN//Phosphoribosylaminoimidazolecarboxamide formyltransferase//IMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.3</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AICAR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLACYLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3048 ) or ( mlr8392 ) or ( mll5431 ) or ( mlr7453 ) or ( mlr8461 ) or ( mll1009 ) or ( mlr1841 ) or ( mlr6976 ) or ( mll6015 ) or ( mll6870 ) or ( mlr5044 ) or ( mlr8134 ) or ( mll5584 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( p-hydroxycinnamoyl CoA hydratase/lyase ) or ( enoyl-CoA hydratase ) or ( carnitine racemase ) or ( enoyl-CoA hydratase ) or ( carnitinyl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3749 ) or ( mll5764 ) or ( mll5765 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase ) or ( transketolase ) or ( transketolase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__148__45__RXN" name="4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7422_ispE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (4-(cytidine-5&apos;-diphospho)-2-C-methyl-D-erythritol kinase)//2.7.1.148-RXN )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.148</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LUMAZINESYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7281_ribH1 ) or ( mlr8409_ribH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6,7-dimethyl-8-ribityllumazine synthase 1 (DMRL synthase 1) (Lumazine synthase 1) (Riboflavin synthase 1 beta chain)//Riboflavin synthase ) or ( 6,7-dimethyl-8-ribityllumazine synthase 2 (DMRL synthase 2) (Lumazine synthase 2) (Riboflavin synthase 2 beta chain)//Riboflavin synthase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__BUTANONE__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BAIAEUBSP__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7199 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-alpha-hydroxysteroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXO__45__CHOLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5822" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4110 ) or ( mll4349 ) or ( mll2704 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acid phosphatase ) or ( protein-tyrosine-phosphatase ) or ( probable acid phosphatase )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__59__45__RXN" name="L-lysine 6-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5923 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysine:N6-hydroxylase )</html:p>
<html:p>SUBSYSTEM: aerobactin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.59</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__265" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRROLINEDEH__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1160 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8551 ) or ( mlr5697 ) or ( mlr6767 ) or ( mll7878 ) or ( mll1234 ) or ( mll1687 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose 4-epimerase ) or ( UDP-galactose 4-epimerase ) or ( probable UDP-glucose 4-epimerase ) or ( UDP-glucose 4-epimerase ) or ( UDP-glucose 4-epimerase ) or ( UDP-galactose 4-epimerase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__64__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3442_ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-demethylubiquinone-9 3-methyltransferase (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (DHHB methyltransferase)//DHHB-METHYLTRANSFER-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LTAA__45__RXN" name="L-allo-threonine aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8400_glyA1 ) or ( mlr6130 ) or ( mlr6114_glyA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Serine hydroxymethyltransferase 1 (Serine methylase 1) (SHMT 1) ) or ( L-threonine aldolase ) or ( Serine hydroxymethyltransferase 2 (Serine methylase 2) (SHMT 2) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALLO__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKAPHOSPHA__45__RXN" name="Alkaline phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4115 ) or ( mlr4525 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( secreted alkaline phosphatase ) or ( quinol oxidase, subunit II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__6__45__OHPHENOL__45__METHY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3442_ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-demethylubiquinone-9 3-methyltransferase (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (DHHB methyltransferase)//DHHB-METHYLTRANSFER-RXN )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__METHOXYPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONOLACT__45__RXN" name="6-phosphogluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6514_pgl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase (6PGL)//6-phosphogluconolactonase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRNA__45__PSEUDOURIDINE__45__SYNTHASE__45__I__45__RXN" name="tRNA-pseudouridine synthase I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4852_truA ) or ( mlr5558_truB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA pseudouridine synthase A (tRNA-uridine isomerase I) (tRNA pseudouridylate synthase I)//TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN ) or ( tRNA pseudouridine synthase B (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA-uridine isomerase) (tRNA pseudouridylate synthase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8538" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8537" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URA__45__PHOSPH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3160_deoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thymidine phosphorylase (TdRPase)//THYM-PHOSPH-RXN//Thymidine phosphorylase )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: URACIL</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_ADP_COF_RXN" name="ATP_TO_ADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GULONOLACTONE__45__OXIDASE__45__RXN" name="L-gulonolactone oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8207 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable oxidoreductase )</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.8</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__329" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCISOM__45__RXN" name="Glucose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5411_pgi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)//PGLUCISOM-RXN//Glucose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMET__45__RXN" name="5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6123_metE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (Methionine synthase, vitamin-B12 independent isozyme) (Cobalamin-independent methionine synthase)//HOMOCYSMET-RXN )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.14</html:p>
<html:p>SIDE: CPD__45__1301</html:p>
<html:p>SIDE: CPD__45__1302</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1302" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1301" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THI__45__P__45__SYN__45__RXN" name="Thiamine-phosphate pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3913 ) or ( mll5789_thiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamine-phosphate pyrophosphorylase ) or ( thiamine-phosphate pyrophosphorylase//THI-P-SYN-RXN )</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.3</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THZ__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8748" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4525 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinol oxidase, subunit II )</html:p>
<html:p>SUBSYSTEM: diethylphosphate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ETOH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8978" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTKIN__45__RXN" name="Glutamate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6298_proB2 ) or ( mll4011_proB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutamate 5-kinase 2 (Gamma-glutamyl kinase 2) (GK 2)//Glutamate 5-kinase ) or ( Glutamate 5-kinase 1 (Gamma-glutamyl kinase 1) (GK 1)//Glutamate 5-kinase )</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYKI__45__RXN" name="Thymidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2747_tdk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thymidine kinase//DURIDKI-RXN//THYKI-RXN//Thymidine kinase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITSYN__45__RXN" name="Citrate (si)-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3842 ) or ( msl6268 ) or ( mlr0629_gltA ) or ( mlr3843 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( citrate synthase 2 ) or ( similar to citrate synthase ) or ( type II citrate synthase//CITSYN-RXN ) or ( citrate synthase II )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8743" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7664 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to resiniferotoxin-binding, phosphotriesterase-related protein )</html:p>
<html:p>SUBSYSTEM: methyl parathion degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8973" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8974" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8746" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7664 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to resiniferotoxin-binding, phosphotriesterase-related protein )</html:p>
<html:p>SUBSYSTEM: paraoxon degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARAOXON" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
      <speciesReference species="DIETHYLPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8747" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0660 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable phosphodiesterase )</html:p>
<html:p>SUBSYSTEM: diethylphosphate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ETOH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIETHYLPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__8978" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPIDADISACCHARIDESYNTH__45__RXN" name="Lipid-A-disaccharide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0630_lpxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipid-A-disaccharide synthase )</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.182</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BISOHMYR__45__GLUCOSAMINYL__45__1P" stoichiometry="1"/>
      <speciesReference species="OH__45__MYRISTOYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BISOHMYR__45__GLC" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHHB__45__METHYLTRANSFER__45__RXN" name="3-demethylubiquinone-9 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3442_ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-demethylubiquinone-9 3-methyltransferase (3,4- dihydroxy-5-hexaprenylbenzoate methyltransferase) (DHHB methyltransferase)//DHHB-METHYLTRANSFER-RXN )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__OH__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4OH2OXOGLUTARALDOL__45__RXN" name="4-hydroxy-2-oxoglutarate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2994 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__4__45__HYDROXY__45__2__45__KETO__45__GLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16BDEPHOS__45__RXN" name="Fructose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0929_glpX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose 1,6-bisphosphatase II//F16BDEPHOS-RXN )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYGLUCONOKIN__45__RXN" name="2-dehydro-3-deoxygluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1166 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-dehydro-3-deoxygluconokinase )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>SUBSYSTEM: D-galacturonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.45</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__20__45__RXN" name="Methylenetetrahydrofolate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1587 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5,10-methylenetetrahydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.20</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDE__45__GLUCOSYLTRANSFERASE__45__RXN" name="Ceramide glucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5650 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceramide glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.80</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSYL_CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPMANDEHYDRA__45__RXN" name="GDP-mannose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5849 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-mannose 4,6-dehydratase (nodulation protein NoeL)//GDP-mannose 4,6-dehydratase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-&amp;alpha;-D-perosamine biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-6-deoxy-D-talose biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-D-rhamnose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.47</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVOXID__45__RXN" name="Pyruvate dehydrogenase (cytochrome)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1433 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetolactate synthase 3 catalytic subunit )</html:p>
<html:p>SUBSYSTEM: pyruvate oxidation pathway</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.2.2.2</html:p>
<html:p>SIDE: UBIQUINOL__45__8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UBIQUINONE__45__8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__KINASE__45__RXN" name="Protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6580 ) or ( mlr2363 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine/threonine kinase ) or ( serine/threonine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTEPADENYLYLTRAN__45__RXN" name="Pantetheine-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0730_coaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphopantetheine adenylyltransferase (Pantetheine- phosphate adenylyltransferase) (PPAT) (Dephospho-CoA pyrophosphorylase)//PANTEPADENYLYLTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.3</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__SULFATASE__45__RXN" name="Choline-sulfatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3684 ) or ( mll7612 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphonate monoester hydrolase ) or ( choline sulfatase )</html:p>
<html:p>SUBSYSTEM: choline-O-sulfate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.6</html:p>
<html:p>SIDE: SULFATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__543" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_7KAPSYN__45__RXN" name="8-amino-7-oxononanoate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6664 ) or ( mll9099 ) or ( mll5830 ) or ( mll6006 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to 2-amino-3-ketobutyrate CoA ligase ) or ( 8-amino-7-oxononanoate synthase ) or ( 8-amino-7-oxononanoate synthase ) or ( 8-amino-7-oxononanoate synthase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.47</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CPD__45__558</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_8__45__AMINO__45__7__45__OXONONANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DECAPCISTRANSFER__45__RXN" name="di-trans-poly-cis-decaprenylcistransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0640_uppS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Undecaprenyl pyrophosphate synthetase (UPP synthetase) (Di-trans,poly-cis-decaprenylcistransferase) (Undecaprenyl diphosphate synthase) (UDS)//Di-trans,poly-cis-decaprenylcistransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="T__45__POLY__45__C__45__DECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="T__45__POLY__45__C__45__UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__AMINOADIPATE__45__AMINOTRANSFERASE__45__RXN" name="2-aminoadipate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1817 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable aminotransferase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.39</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXINE__45__4__45__DEHYDROGENASE__45__RXN" name="Pyridoxine 4-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1801 ) or ( mlr5051 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo/keto reductase ) or ( oxidoreductase, aldo/keto reductase family )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.65</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTACETYLTRAN__45__RXN" name="Maltose O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2768 ) or ( mlr2192 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyltransferase, nodulation protein nodL ) or ( O-acetyltransferase, nodL candidate )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.79</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLMALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__SORBITOL__45__DEHYDROGENASE__45__RXN" name="D-sorbitol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4921 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.21</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__HEXADECENAL__45__REDUCTASE__45__RXN" name="2-hexadecenal reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5022 ) or ( mll1451 ) or ( mlr2417 ) or ( mlr7692 ) or ( mlr6843 ) or ( mll9173 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine protease, HtrA/DegQ/DegS family ) or ( probable serine protease ) or ( serine protease ) or ( serine protease ) or ( quinone oxidoreductase ) or ( putative protease )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.27</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__292" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMITALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3848 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-ketothiolase, acetoacetyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: polyhydroxybutyrate biosynthesis</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOLINATE__45__SYNTHA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5835_nadA1 ) or ( mll9104_nadA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Quinolinate synthetase A 1 ) or ( Quinolinate synthetase A 2 )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: DIHYDROXY__45__ACETONE__45__PHOSPHATE</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="IMINOASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIP__45__KIN__45__RXN" name="Nucleoside-diphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7917_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINAMID__45__RXN" name="Nicotinamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4882 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrazinamidase/nicotinamidase )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_ACETYL__45__COA_COF_RXN" name="CO-A_TO_ACETYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIOSEPISOMERIZATION__45__RXN" name="Triosephosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7275_tpiA2 ) or ( mll0610_tpiA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Triosephosphate isomerase 2 (TIM 2) (Triose-phosphate isomerase 2)//Triose-phosphate isomerase ) or ( Triosephosphate isomerase 1 (TIM 1) (Triose-phosphate isomerase 1)//Triose-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__AMINOLEVULINIC__45__ACID__45__SYNTHASE__45__RXN" name="5-aminolevulinic acid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5695 ) or ( mll6600 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-aminolevulinate synthase ) or ( 5-aminolevulinate synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.37</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5226" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1089 ) or ( mll9166 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable sugar hydrolase ) or ( glycosyl hyrolase, family 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.52</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__882" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5225" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0213 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylmuramoyl-L-alanine amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1080" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1082" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R341__45__RXN" name="Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1387_cobB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cobyrinic acid A,C-diamide synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__687" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__688" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Serine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1322 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable serine-glyoxylate aminotransferase )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__221" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0712 ) or ( mlr4653 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid decarboxylase ) or ( aromatic-L-amino-acid decarboxylase )</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopamine)</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8766" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1383 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 6y methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9044" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9048" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8767" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1383 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 6y methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9048" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9045" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8764" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1383 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 6y methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9047" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9043" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8762" name="Precorrin-4 C11-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1385 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 3 methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.133</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9042" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TIGLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3048 ) or ( mlr8392 ) or ( mll5431 ) or ( mlr7453 ) or ( mlr8461 ) or ( mll1009 ) or ( mlr1841 ) or ( mlr6976 ) or ( mll6015 ) or ( mll6870 ) or ( mlr5044 ) or ( mlr8134 ) or ( mll5584 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( p-hydroxycinnamoyl CoA hydratase/lyase ) or ( enoyl-CoA hydratase ) or ( carnitine racemase ) or ( enoyl-CoA hydratase ) or ( carnitinyl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8761" name="Precorrin-3B C17-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1381 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin-3B C17-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.131</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9040" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9041" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROKAEMPFEROL__45__4__45__REDUCTASE__45__RXN" name="Dihydrokaempferol 4-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1975 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable cinnamoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.219</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROKAEMPFEROL__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LEUCOPELARGONIDIN__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2NEOPTERINALDOL__45__RXN" name="Dihydroneopterin aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0787 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroneopterin aldolase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.25</html:p>
<html:p>SIDE: GLYCOLALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__NEO__45__PTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
      <speciesReference species="GLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__CARBOXYMUCONOLACTONE__45__DECARBOXYLASE__45__RXN" name="4-carboxymuconolactone decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7207 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma carboxymuconolactone decarboxylase )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.44</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7737" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXOADIPATE__45__ENOL__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__80__45__RXN" name="N-acetylgalactosamine-6-phosphate deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4766 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine-6-phosphate deacetylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R8__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4183 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetate CoA-transferase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="CPD__45__19" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__20" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPAMIDOTRANS__45__RXN" name="Amidophosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7833 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidophosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.14</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDP_TO_CTP_COF_RXN" name="CDP_TO_CTP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOSEPHOSPHO__45__RXN" name="Protein-N(PI)-phosphohistidine-sugar phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3194 ) or ( mll3613 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphotransferase system enzyme II ) or ( phosphotransferase system enzyme II, BC COMPONENT )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__12__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5797 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-pyruvoyl tetrahydrobiopterin synthase )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.12</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6250_tynA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyramine oxidase//AMACETOXID-RXN//AMINEOXID-RXN//AMINEPHEN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLISOM__45__RXN" name="Xylose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4975 ) or ( mlr5036_xylA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( contains weak similarity to Xylose Isomerase (E.C.5.3.1.5) ) or ( Xylose isomerase//XYLISOM-RXN//Xylose isomerase )</html:p>
<html:p>SUBSYSTEM: xylose degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8751" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5134 ) or ( mlr5135 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase, xdhA ) or ( xanthine dehydrogenase, xdhB )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8752" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5134 ) or ( mlr5135 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase, xdhA ) or ( xanthine dehydrogenase, xdhB )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__OXIDASE__45__RXN" name="Sulfite oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2597 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable sulfite oxidase )</html:p>
<html:p>SUBSYSTEM: sulfite oxidation IV</html:p>
<html:p>PROTEIN_CLASS: 1.8.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7045 ) or ( mll2867 ) or ( mll1015 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8753" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5134 ) or ( mlr5135 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase, xdhA ) or ( xanthine dehydrogenase, xdhB )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9017" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3048 ) or ( mlr8392 ) or ( mll5431 ) or ( mlr7453 ) or ( mlr8461 ) or ( mll1009 ) or ( mlr1841 ) or ( mlr6976 ) or ( mll6015 ) or ( mll6870 ) or ( mlr5044 ) or ( mlr8134 ) or ( mll5584 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( p-hydroxycinnamoyl CoA hydratase/lyase ) or ( enoyl-CoA hydratase ) or ( carnitine racemase ) or ( enoyl-CoA hydratase ) or ( carnitinyl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8754" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5134 ) or ( mlr5135 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase, xdhA ) or ( xanthine dehydrogenase, xdhB )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9017" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QOR__45__RXN" name="NADPH:quinone reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8195 ) or ( mlr3236 ) or ( mll1929 ) or ( mll2116 ) or ( mlr6843 ) or ( mlr7750 ) or ( mll0505 ) or ( mll2578 ) or ( mll3767 ) or ( mlr1178 ) or ( mll2594 ) or ( mll7162 ) or ( mlr2819 ) or ( mll7125 ) or ( mll3915 ) or ( mlr3212 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase ) or ( oxidoreductase ) or ( probable alcohol dehydrogenase ) or ( probable zinc-binding oxidoreductase ) or ( quinone oxidoreductase ) or ( alginate lyase ) or ( quinone oxidoreductase ) or ( alcohol dehydrogenase ) or ( NADPH quinone oxidoreductase ) or ( alcohol dehydrogenase ) or ( probable quinone oxidoreductase ) or ( quinone oxidoreductase ) or ( probable oxidoreductase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase (NADPH quinone oxidoreductase) ) or ( dehydrogenase (zinc-binding alcohol dehydrogenase, NADPH quinone oxidoreductase, oxidoreductase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Semiquinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_GLT_COF_RXN" name="2-KETOGLUTARATE_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCONDEHYDRAT__45__RXN" name="Phosphogluconate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6512 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphogluconate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEPHOSPHORYLATION__45__RXN" name="5&apos;-nucleotidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1080_surE ) or ( mlr3017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase)//5&apos;-NUCLEOTID-RXN//5&apos;-nucleotidase ) or ( 5&apos;-nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PABASYN__45__RXN" name="Aminodeoxychorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( para-aminobenzoate synthase component I )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.8</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8442 ) or ( mll7185 ) or ( mlr9382 ) or ( mlr5647_argF ) or ( mlr7545 ) or ( mlr4191 ) or ( mlr5384 ) or ( mll2949 ) or ( mlr6967 ) or ( mlr3665 ) or ( mll1739 ) or ( mlr7381 ) or ( mll0233 ) or ( mlr1667 ) or ( mll2887 ) or ( mlr9016 ) or ( mlr6080 ) or ( mlr6537 ) or ( mlr2022 ) or ( mll6253 ) or ( mlr4192 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ABC transporter, permease protein ) or ( ABC transporter, permease protein ) or ( permease of ABC transporter ) or ( Ornithine carbamoyltransferase (OTCase)//ORNCARBAMTRANSFER-RXN//Ornithine carbamoyltransferase ) or ( ABC transporter permease protein ) or ( spermidine/putrescine ABC transporter, permease protein ) or ( ABC transporter, permease protein ) or ( ABC transporter, permease protein ) or ( ABC transporter, permease protein ) or ( spermidine/putrescine ABC transporter, permease protein ) or ( permease protein of polyamine ABC transporter ) or ( ABC transporter, permease protein ) or ( probable permease of ABC transporter ) or ( permease protein of sulfate ABC transporter ) or ( ABC transporter, permease ) or ( ABC transporter, permease ) or ( ABC transporter, permease ) or ( ABC transporter, polyamine transport protein, permease protein ) or ( permease protein of spermidine/putrescine ABC transporter ) or ( ABC transporter permease protein ) or ( spermidine/putrescine ABC transporter, permease protein )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: CARBAMOYL__45__P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTERIDINEPYROPHOSPHOKIN__45__RXN" name="2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0786 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDPGALDOL__45__RXN" name="2-dehydro-3-deoxyphosphogluconate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2994 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8505" name="4-hydroxyphenylacetate 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1411 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable FAD-dependent monooxygenase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.-</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXYPHENYLACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4301" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2561 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable phosphoheptose isomerase )</html:p>
<html:p>SUBSYSTEM: ADP-L-glycero-&amp;beta;-D-manno-heptose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALPHABETA__45__D__45__HEPTOSE__45__7__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATREDUCT__45__RXN" name="Nitrate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5614 ) or ( mlr2864 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DMSO reductase chain A ) or ( nitrate reductase large subunit )</html:p>
<html:p>SUBSYSTEM: nitrate reduction I (denitrification)</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.4</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__NH3__45__RXN" name="NAD(+) synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6744_nadE ) or ( mll0818_nadE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NH(3)-dependent NAD(+) synthetase//NAD-SYNTH-NH3-RXN ) or ( NAD synthetase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__0" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1969 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2141" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7593 ) or ( mll5109 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycosyl hydrolase ) or ( alpha-glucosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCC__45__FUM__45__OXRED__45__RXN" name="Succinate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4260_sdhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate dehydrogenase iron-sulfur subunit )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHAGALACTOSID__45__RXN" name="&amp;alpha;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6443 ) or ( mlr6450 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-galactosidase ) or ( alpha-galactosidase )</html:p>
<html:p>SUBSYSTEM: melibiose degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MELIBIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETRAACYLDISACC4KIN__45__RXN" name="Tetraacyldisaccharide 4&apos;-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8270_lpxK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tetraacyldisaccharide 4&apos;-kinase (Lipid A 4&apos;-kinase)//TETRAACYLDISACC4KIN-RXN//Tetraacyldisaccharide 4&apos;-kinase )</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.130</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BISOHMYR__45__GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPID__45__IV__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALARACECAT__45__RXN" name="Alanine racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1020 ) or ( mlr9371_alr3 ) or ( mll3997_dadB ) or ( mll6211_alr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-resistance amylase regulator ) or ( Alanine racemase 3//Alanine racemase ) or ( Alanine racemase, catabolic//Alanine racemase ) or ( Alanine racemase, biosynthetic//ALARACECAT-RXN//Alanine racemase )</html:p>
<html:p>SUBSYSTEM: alanine degradation I</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3249 ) or ( mlr7821_psd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycosyltransferase, RedB [Sinorhizobium meliloti] megaplasmid 2 ) or ( Phosphatidylserine decarboxylase proenzyme [Contains: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain]//Phosphatidylserine decarboxylase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.65</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5061" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2566 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-heptose-LPS heptosyltransferase )</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__929" stoichiometry="1"/>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="CPD0__45__930" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CEREBROSIDE__45__SULFATASE__45__RXN" name="Cerebroside-sulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5471 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylsulfatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSYLCERAMIDE__45__SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__45__GALACTOSYLCERAMIDE" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTARYL__45__COA__45__DEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2878 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl Co-A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDUD__45__RXN" name="2-deoxy-D-gluconate 3-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4054 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-deoxy-D-gluconate 3-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.125</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DE__45__O__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DE__45__O__45__K__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5057" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2566 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-heptose-LPS heptosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
      <speciesReference species="KDO2__45__LIPID__45__IVA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="HEPTOSYL__45__KDO2__45__LIPID__45__IVA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCGLU__45__SEMIALDEHYDE__45__SUCCGLU__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1160 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__SUCCINYLGLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCOSEPP__45__RXN" name="Glucose-1-phosphate thymidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7550 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-1-phosphate thymidylyltransferase )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.24</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARDIOLIPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8077 ) or ( mlr2852 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cardiolipin synthetase family protein ) or ( cardiolipin synthase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>SIDE: GLYCEROL</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARDIOLIPIN" stoichiometry="1"/>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYMETHYLENEBUTENOLIDASE__45__RXN" name="Carboxymethylenebutenolidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1495 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable carboxymethylenebutenolidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CARBOXYMETHYLENEBUT__45__2__45__EN__45__4__45__OLIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXOHEX__45__2__45__ENEDIOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__20__45__RXN" name="4-hydroxybenzoyl-CoA reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1926 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxidoreductase, molybdopterin binding subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.20</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__201" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMIDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5016_hisF ) or ( mlr5011_hisH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Imidazole glycerol phosphate synthase subunit hisF (IGP synthase cyclase subunit) (IGP synthase subunit hisF) (ImGP synthase subunit hisF) (IGPS subunit hisF) ) or ( Imidazole glycerol phosphate synthase subunit hisH (IGP synthase glutamine amidotransferase subunit) (IGP synthase subunit hisH) (ImGP synthase subunit hisH) (IGPS subunit hisH) )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2301" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7732 ) or ( mlr6975 ) or ( mll0685 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isovaleryl-CoA-dehydrogenase ) or ( probable acyl-CoA dehydrogenase ) or ( probable acyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATEPRIBOSYLTRANS__45__RXN" name="Nicotinate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4892_pncB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nicotinate phosphoribosyltransferase (NAPRTase)//NICOTINATEPRIBOSYLTRANS-RXN//Nicotinate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.11</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8529" name="4-oxalocrotonate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( msl4326 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-oxalocrotonate tautomerase )</html:p>
<html:p>SUBSYSTEM: catechol degradation II (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: catechol degradation to 2-oxopent-4-enoate II</html:p>
<html:p>PROTEIN_CLASS: 5.3.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8720" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__246" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PURINE__45__NUCLEOSIDASE__45__RXN" name="Purine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2009 ) or ( mll3190 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine-uridine preferring nucleoside hydrolase ) or ( nucleoside hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPICRED__45__RXN" name="Dihydrodipicolinate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4642_dapB1 ) or ( mlr7948_dapB2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydrodipicolinate reductase 1 (DHPR 1)//Dihydrodipicolinate reductase ) or ( Dihydrodipicolinate reductase 2 (DHPR 2)//Dihydrodipicolinate reductase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.26</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7917_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside diphosphate kinase (NDK) (NDP kinase) (Nucleoside-2-P kinase)//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYRIBOSE__45__P__45__ALD__45__RXN" name="Deoxyribose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4784 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyribose-phosphate aldolase )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTDEAM__45__RXN" name="Cytosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2061 ) or ( mll1290 ) or ( mlr5363 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosine deaminase ) or ( cytosine deaminase ) or ( cytosine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPIONYL__45__COA__45__CARBOXY__45__RXN" name="Propionyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6012 ) or ( mll0348 ) or ( mll0871 ) or ( mll7731 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl/propionyl CoA carboxylase, beta subunit ) or ( propionyl-CoA carboxylase ) or ( propionyl-CoA carboxylase alpha chain precursor ) or ( acetyl/propionyl CoA carboxylase, beta subunit )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__DECARBOXYLASE__45__RXN" name="UDP-glucuronate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7879 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-glucose 4-6-dehydratase )</html:p>
<html:p>SUBSYSTEM: UDP-D-xylose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.35</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="Myo-inositol-1(or 4)-monophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8265 ) or ( mll3039 ) or ( mlr4874 ) or ( mlr0048 ) or ( mll6642 ) or ( mlr3921_suhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myo-inositol monophosphatase 2 ) or ( Mono-phosphatase ) or ( myo-inositol-1-monophosphotase (also similar to extragenic suppressor protein SuhB) ) or ( monophosphatase-like protein ) or ( N-amidino-scyllo-inosamine-4-phosphate phosphatase ) or ( Inositol-1-monophosphatase (IMPase) (Inositol-1- phosphatase) (I-1-Pase)//MYO-INOSITOL-1(OR-4)-MONOPHOSPHATASE-RXN )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALANINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Alanine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6991 ) or ( mlr7169 ) or ( mlr6024 ) or ( mlr6806 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to aminotransferase ) or ( probable aminotransferase ) or ( putative aminotransferase ) or ( aspartate aminotransferase )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.44</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINE__45__NUCLEOSIDASE__45__RXN" name="Adenosylhomocysteine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6947 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-methylthioadenosine/S-adenosylhomocysteine nucleosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__564" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETATEKIN__45__RXN" name="Acetate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6576 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetate kinase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate II</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTMPKI__45__RXN" name="Thymidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0424_tmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thymidylate kinase (dTMP kinase)//DTMPKI-RXN//dTMP kinase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTAGLY__45__RXN" name="Cystathionine &amp;gamma;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1566 ) or ( mll4503 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine gamma-lyase ) or ( cystathionine gamma-lyase )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>SUBSYSTEM: homocysteine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE__45__1__45__EPIMERASE__45__RXN" name="Aldose 1-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1167 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldose 1-epimerase )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__ALANINE__45__AMINOTRANSFERASE__45__RXN" name="D-alanine aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0401 ) or ( mlr1594 ) or ( mll9205 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-amino acid aminotransferase ) or ( branched-chain amino acid transferase ) or ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYMETVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7192 ) or ( mlr5404 ) or ( mll1102_ilvD2 ) or ( mlr5361_ilvD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxy-acid dehydratase ) or ( dihydroxy-acid dehydratase ) or ( Dihydroxy-acid dehydratase 2 (DAD 2)//Dihydroxy-acid dehydratase ) or ( Dihydroxy-acid dehydratase 1 (DAD 1)//Dihydroxy-acid dehydratase )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8925" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1207 ) or ( mlr5987 ) or ( mlr6024 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aminotransferase ) or ( putative aminotransferase ) or ( putative aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="an__32__amine__32__donor" stoichiometry="1"/>
      <speciesReference species="VANILLIN" stoichiometry="1"/>
      <speciesReference species="__124__Amineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="deaminated__32__donor" stoichiometry="1"/>
      <speciesReference species="CPD__45__9327" stoichiometry="1"/>
      <speciesReference species="__124__Deamineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINLYA__45__RXN" name="Argininosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9226_argH2 ) or ( mlr3506_argH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Argininosuccinate lyase 2 (Arginosuccinase 2) (ASAL 2)//Argininosuccinate lyase ) or ( Argininosuccinate lyase 1 (Arginosuccinase 1) (ASAL 1)//Argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3902" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2878 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl Co-A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MUCONATE__45__CYCLOISOMERASE__45__RXN" name="Muconate cycloisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0803 ) or ( mll7353 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable muconate cycloisomerase ) or ( muconate lactonizing enzyme )</html:p>
<html:p>SUBSYSTEM: catechol degradation to &amp;beta;-ketoadipate</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__CIS__45__MUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__741" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPNACETYLGLUCOSAMENOLPYRTRANS__45__RXN" name="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6459_murA1 ) or ( mll7251_murA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 (Enoylpyruvate transferase 1) (UDP-N-acetylglucosamine enolpyruvyl transferase 1) (EPT 1)//UDP-N-acetylglucosamine 1-carboxyvinyltransferase ) or ( UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 (Enoylpyruvate transferase 2) (UDP-N-acetylglucosamine enolpyruvyl transferase 2) (EPT 2)//UDP-N-acetylglucosamine 1-carboxyvinyltransferase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.7</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_ACYL__45__COA_COF_RXN" name="CO-A_TO_ACYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6841" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0710_glpD ) or ( mlr4225_gpsA ) or ( mlr7270 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase//GLYC3PDEHYDROG-RXN ) or ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN ) or ( glycerol-3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NACGLCTRANS__45__RXN" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3120 ) or ( mll2073 ) or ( mlr6692 ) or ( mll1554_murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-linked GlcNAc transferase ) or ( probable O-linked GlcNAc transferase ) or ( similar to O-linked GlcNAc transferase ) or ( UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase)//NACGLCTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C5" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3048 ) or ( mlr8392 ) or ( mll5431 ) or ( mlr7453 ) or ( mlr8461 ) or ( mll1009 ) or ( mlr1841 ) or ( mlr6976 ) or ( mll6015 ) or ( mll6870 ) or ( mlr5044 ) or ( mlr8134 ) or ( mll5584 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( p-hydroxycinnamoyl CoA hydratase/lyase ) or ( enoyl-CoA hydratase ) or ( carnitine racemase ) or ( enoyl-CoA hydratase ) or ( carnitinyl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMEOSYN__45__RXN" name="heme o biosynthesis" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7493 ) or ( mll1047 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoheme IX farnesyltransferase ) or ( protoheme IX farnesyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEME_O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCDEHYDROG__45__RXN" name="Phosphoglycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3367 ) or ( mlr9208 ) or ( mlr7269 ) or ( mll3875 ) or ( mlr7122 ) or ( mll7048 ) or ( mlr4731 ) or ( mll1021 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate dehydrogenase ) or ( phosphoglycerate dehydrogenase ) or ( phosphoglycerate dehydrogenase ) or ( phosphoglycerate dehydrogenase ) or ( phosphoglycerate dehydrogenase ) or ( probable dehydrogenase ) or ( D-3-phosphoglycerate dehydrogenase ) or ( phosphoglycerate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.95</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTCYSLIG__45__RXN" name="Glutamate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6902 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamylcysteine synthetase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7698" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3848 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-ketothiolase, acetoacetyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNTRANSAM__45__RXN" name="Acetylornithine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5646_argD ) or ( mlr6714 ) or ( mll1261 ) or ( mll0107 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine aminotransferase (ACOAT)//ACETYLORNTRANSAM-RXN ) or ( ornithine-oxo-acid transaminase ) or ( probable aminotransferase ) or ( aminotransferase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.11</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__469" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8172" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__6__45__AMINO__45__CAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREOSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMPSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0079 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNONOXIDOREDUCT__45__RXN" name="Fructuronate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1886 ) or ( mlr4057 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-mannonate oxidoreductase ) or ( mannitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.57</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__MANNONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8173" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7682" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENIIISYN__45__RXN" name="uroporphyrinogen-III synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4221 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen-III synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.75</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__2__45__DEHYDROGENASE__45__RXN" name="Myo-inositol 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4991 ) or ( mll7219 ) or ( mll1000 ) or ( mll2825 ) or ( mlr2436 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myo-inositol dehydrogenase (idhA) ) or ( dehydrogenase ) or ( dehydrogenase ) or ( probable oxidoreductase ) or ( NADH-dependent dyhydrogenase )</html:p>
<html:p>SUBSYSTEM: myo-inositol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.18</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__365" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__CYCLODEAMINASE__45__RXN" name="Ornithine cyclodeaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7139 ) or ( mlr1729 ) or ( mll6776 ) or ( mlr3204 ) or ( mlr2282 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine cyclodeaminase ) or ( ornithine cyclodeaminase ) or ( ornithine cyclodeaminase ) or ( ornithine cyclodeaminase ) or ( ornithine cyclodeaminase )</html:p>
<html:p>SUBSYSTEM: ornithine degradation (proline biosynthesis)</html:p>
<html:p>SUBSYSTEM: arginine degradation VII (arginase 3 pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETHYDPICSUCC__45__RXN" name="2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4843_dapD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (Tetrahydrodipicolinate N-succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase)//TETHYDPICSUCC-RXN//2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.117</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__SUCCINYL__45__2__45__AMINO__45__6__45__KETOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TAGAKIN__45__RXN" name="Tagatose-6-phosphate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7215 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable tagatose 6-phosphate kinase agaz )</html:p>
<html:p>SUBSYSTEM: galactitol degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.144</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAGATOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAGATOSE__45__1__45__6__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATEREDUCT__45__RXN" name="Dihydrofolate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1457 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__118__45__RXN" name="N-hydroxyarylamine O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5814 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-hydroxyarylamine O-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.118</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Hydroxy__45__Arylamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__N__45__Acetoxy__45__Arylamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCTP__45__DEAM__45__RXN" name="dCTP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5652 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2&apos;-deoxycytidine 5&apos;-triphosphate deaminase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.13</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBUTYRYL__45__COA__45__DEHYDROGENASE__45__RXN" name="3-hydroxybutyryl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6793 ) or ( mlr3490 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydrogenase ) or ( 3-hydroxybutyryl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.157</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__3__45__HYDROXYBUTANOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7693" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3070 ) or ( mll5720 ) or ( mlr1913 ) or ( mlr1136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase) ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7031" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7032" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNDEAM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr8405 ) or ( mlr2151 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( riboflavin-specific deaminase / reductase ) or ( probable riboflavin-specific deaminase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.26</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__17__45__RXN" name="Calcium/calmodulin-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2363 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine/threonine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7694" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3070 ) or ( mll5720 ) or ( mlr1913 ) or ( mlr1136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrogenase, (iron-containing alcohol dehydrogenase, 4-hydroxybutyrate dehydrogenase, methanol dehydrogenase) ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLBUT__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7033" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM__45__RXN" name="Cytidine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3158 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCDEHYDRAT__45__RXN" name="dTDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7558 ) or ( mlr7552 ) or ( mlr6767 ) or ( mll7879 ) or ( mll1262 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative sugar nucleotide epimerase/dehydratase ) or ( dTDP-D-glucose-4,6-dehydratase ) or ( probable UDP-glucose 4-epimerase ) or ( dTDP-glucose 4-6-dehydratase ) or ( NDP-glucose 4,6-dehydratase )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.46</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9024" name="Glucan 1,4-&amp;alpha;-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4205 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucoamylase, (GLUCAN 1,4-ALPHA-GLUCOSIDASE) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9025" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7586 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAHPSYN__45__RXN" name="2-dehydro-3-deoxyphosphoheptonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0826 ) or ( mll4988 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable 2-dehydro-3-deoxyphosphoheptonate aldolase ) or ( phospho-2-dehydro-3-heoxyheptonate aldolase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.54</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="adenylosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3873_purA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenylosuccinate synthetase (IMP--aspartate ligase) (AdSS) (AMPSase)//ADENYLOSUCCINATE-SYNTHASE-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.4</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMACTRANS__45__RXN" name="Diamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1969 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aliphatic__45__N__45__Acetyl__45__Diamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOGLUCMUT__45__RXN" name="Phosphoglucomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7590 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglucomutase )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5411_pgi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)//PGLUCISOM-RXN//Glucose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEH__45__RXN" name="Malate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9216 ) or ( mll4308_mdh ) or ( mlr9117 ) or ( mll5197 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable malate dehydrogenase ) or ( Malate dehydrogenase//MALATE-DEH-RXN//Malate dehydrogenase ) or ( malate dehydrogenase-like protein ) or ( similar to malate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: aspartate degradation II</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.37</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__5" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7045 ) or ( mll2867 ) or ( mll1015 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__2__46__20__45__RXN" name="2-dehydro-3-deoxyglucarate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5426 ) or ( mlr0073 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-2-oxovalerate aldolase ) or ( 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__D__45__GLUCARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIMSYN1__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5795_thiC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thiamine biosynthesis protein thiC )</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNPOXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7454_pdxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyridoxamine 5&apos;-phosphate oxidase (PNP/PMP oxidase) (PNPOx)//PMPOXI-RXN//PNPOXI-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNCOARACE__45__RXN" name="carnitine racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6015 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine racemase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.-.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__CARNITINYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CARNITINYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1644 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable sterol methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.41</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYCLOARTENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__696" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__16__45__RXN" name="Serine/threonine specific protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2361 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable phosphoprotein phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.16</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONATE__45__5__45__DEHYDROGENASE__45__RXN" name="Gluconate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3785 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gluconate 5-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>SUBSYSTEM: L-idonate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.69</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__DEHYDROGLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__TRIPHOSPHATASE__45__RXN" name="Nucleoside-triphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4626 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleoside-triphosphatase (Nucleoside triphosphate phosphohydrolase) (NTPase)//Nucleoside-triphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__4" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3668 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to monoamine oxidase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTP_TO_CMP_COF_RXN" name="CTP_TO_CMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4216 ) or ( mlr6950_guaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamine amidotransferase ) or ( GMP synthase [glutamine-hydrolyzing] (Glutamine amidotransferase) (GMP synthetase)//GMP-SYN-GLUT-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.2</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7070 ) or ( mll3370 ) or ( mlr9017 ) or ( mlr2310 ) or ( mlr5350 ) or ( mlr2975 ) or ( mlr3187 ) or ( mlr0229 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidase ) or ( amidase ) or ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( amidase ) or ( probable amidase ) or ( amidase ) or ( amidase ) or ( amidase )</html:p>
<html:p>SUBSYSTEM: anandamide degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7598" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOATE__45__BETA__45__ALANINE__45__LIG__45__RXN" name="Pantoate--&amp;beta;-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0196_panC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pantothenate synthetase (PS) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme)//PANTOATE-BETA-ALANINE-LIG-RXN//Pantoate--beta-alanine ligase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROLINE__45__RACEMASE__45__RXN" name="Proline racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6810 ) or ( mll3979 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline racemase ) or ( proline racemase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__PROLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FPPSYN__45__RXN" name="geranyltranstransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7442_ubiA ) or ( mlr3784 ) or ( mlr6368 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase ) or ( geranyltranstransferase (farnesyl-diphosphate synthase) ) or ( geranyltranstransferase )</html:p>
<html:p>SUBSYSTEM: geranylgeranyldiphosphate biosynthesis II (plastidic)</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NADP__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5329 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malic enzyme )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.40</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCIT__45__CLEAV__45__RXN" name="Isocitrate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6527 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate lyase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYPHENYLPYRUVATE__45__DIOXYGENASE__45__RXN" name="4-hydroxyphenylpyruvate dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8309 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxyphenylpyruvate dioxygenase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.27</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1__45__42" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0937 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( poly-beta-hydroxybutyrate synthase )</html:p>
<html:p>SUBSYSTEM: polyhydroxybutyrate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CPD__45__650</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
      <speciesReference species="PHB" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHB" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTOLDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7107_hisD3 ) or ( mlr6649_hisD2 ) or ( mll6456_hisD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Histidinol dehydrogenase 3 (HDH 3)//Histidinol dehydrogenase ) or ( Histidinol dehydrogenase 2 (HDH 2)//Histidinol dehydrogenase ) or ( Histidinol dehydrogenase 1 (HDH 1)//Histidinol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBINAMIDEKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1308 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cobinamide kinase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.156</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R9__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3048 ) or ( mlr8392 ) or ( mll5431 ) or ( mlr7453 ) or ( mlr8461 ) or ( mll1009 ) or ( mlr1841 ) or ( mlr6976 ) or ( mll6015 ) or ( mll6870 ) or ( mlr5044 ) or ( mlr8134 ) or ( mll5584 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( p-hydroxycinnamoyl CoA hydratase/lyase ) or ( enoyl-CoA hydratase ) or ( carnitine racemase ) or ( enoyl-CoA hydratase ) or ( carnitinyl-CoA dehydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5076 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthase (folC) )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9000" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4194 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to macrolide glycosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9459" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9460" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD_TO_NADH_COF_RXN" name="NAD_TO_NADH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROGBIOSYN__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4225_gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycerol-3-phosphate dehydrogenase [NAD(P)+] (NAD(P)H- dependent glycerol-3-phosphate dehydrogenase)//GLYC3PDEHYDROGBIOSYN-RXN )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.94</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FMNH2_TO_FMN_COF_RXN" name="FMNH2_TO_FMN_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FMNH2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHENYLTHFCYCLOHYDRO__45__RXN" name="Methenyltetrahydrofolate cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6508_folD1 ) or ( mll6921_folD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional protein folD 1 [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//Methenyltetrahydrofolate cyclohydrolase ) or ( Bifunctional protein folD 2 [Includes: Methylenetetrahydrofolate dehydrogenase ; Methenyltetrahydrofolate cyclohydrolase ]//Methenyltetrahydrofolate cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: reductive acetyl coenzyme A pathway</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__PPENTOMUT__45__RXN" name="Phosphopentomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5587_deoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphopentomutase (Phosphodeoxyribomutase)//D-PPENTOMUT-RXN//PPENTOMUT-RXN//Phosphopentomutase )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYLESTERASE__45__RXN" name="Carboxylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7099 ) or ( mll1900 ) or ( mlr2794 ) or ( mlr6787 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( esterase ) or ( probable hydrolase ) or ( dihydrolipoamide S-acetyltransferase ) or ( putative hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Carboxylic__45__esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__PHOSPHOGLUCOMUTASE__45__RXN" name="&amp;beta;-phosphoglucomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr3618 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative hydrolase )</html:p>
<html:p>SUBSYSTEM: trehalose degradation IV</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__448" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHLAXANAU__45__RXN" name="Haloalkane dehalogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2612 ) or ( mlr5354_dhaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxymuconic semialdehyde hydrolase ) or ( Haloalkane dehalogenase//Haloalkane dehalogenase )</html:p>
<html:p>SUBSYSTEM: 1,2-dichloroethane degradation pathway</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_12__45__DICHLOROETHANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="_2__45__CHLOROETHANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__15__45__RXN" name="Diaminopropionate ammonia-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7936 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaminopropionate ammonia-lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1782" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2PGADEHYDRAT__45__RXN" name="Phosphopyruvate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0378_eno )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Enolase (2-phosphoglycerate dehydratase) (2-phospho-D- glycerate hydro-lyase)//2PGADEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMKALT__45__RXN" name="T2-induced deoxynucleotide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7857_gmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Guanylate kinase (GMP kinase)//GUANYL-KIN-RXN//Guanylate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOKIN__45__RXN" name="Gluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1676 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gluconokinase )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>SUBSYSTEM: L-idonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZYL__45__ALCOHOL__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2491 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: m-cresol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OH__45__BENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OH__45__BENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8972" name="UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1560_murE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase (UDP-N-acetylmuramyl-tripeptide synthetase) (Meso- diaminopimelate-adding enzyme) (UDP-MurNAc-tripeptide synthetase)//UDP-NACMURALGLDAPLIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Lysine__45__or__45__DAP__124__" stoichiometry="1"/>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__UDP__45__N__45__acetylmuramoyl__45__Tripeptide__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERSYN__45__RXN" name="CDP-diacylglycerol--serine O-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7822 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine synthase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.8</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOLATEDEHYDRO__45__RXN" name="Glycolate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6916 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycolate oxidase subunit GlcD )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation (E. coli)</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation II</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.14</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8973" name="UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1559 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
      <speciesReference species="__124__UDP__45__N__45__acetylmuramoyl__45__Tripeptide__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__UDP__45__NAcMur__45__Peptides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__6__46__1__46__10__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5797 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-pyruvoyl tetrahydrobiopterin synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__ETCETERA__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__ETCETERA__45__DIHYDROXYPTERIDINE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8976" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1554_murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase)//NACGLCTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7695" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA_TO_CO__45__A_COF_RXN" name="MALONYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8975" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1558_mraY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phospho-N-acetylmuramoyl-pentapeptide-transferase (UDP- MurNAc-pentapeptide phosphotransferase)//PHOSNACMURPENTATRANS-RXN//Phospho-N-acetylmuramoyl-pentapeptide-transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C3" stoichiometry="1"/>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C4" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__88__45__RXN" name="Peptide deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4855_def )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peptide deformylase (PDF) (Polypeptide deformylase)//3.5.1.88-RXN//Peptide deformylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.88</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNDECARBOX__45__RXN" name="Ornithine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1584 ) or ( mll2974 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine decarboxylase ) or ( ornithine decarboxylase )</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.17</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__KIN__45__RXN" name="Glycerol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0700_glpK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycerol kinase (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK)//GLYCEROL-KIN-RXN//Glycerol kinase )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.30</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UNDECAPRENYL__45__DIPHOSPHATASE__45__RXN" name="Undecaprenyl-diphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4634_uppP1 ) or ( mlr0116_uppP2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Undecaprenyl-diphosphatase 1 (Undecaprenyl pyrophosphate phosphatase 1) (Bacitracin resistance protein 1)//Undecaprenyl-diphosphatase ) or ( Undecaprenyl-diphosphatase 2 (Undecaprenyl pyrophosphate phosphatase 2) (Bacitracin resistance protein 2)//Undecaprenyl-diphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.27</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7164 ) or ( mll4981 ) or ( mll1433 ) or ( mll1432_ilvH ) or ( mlr6648 ) or ( mlr1615 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetolactate synthase ) or ( acetolactate synthase, iolD ) or ( acetolactate synthase 3 catalytic subunit ) or ( acetolactate synthase 3 regulatory subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN ) or ( acetolactate synthase, large subunit ) or ( acetolactate synthase 2 catalytic subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: butanediol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__16__45__RXN" name="Isoquinoline 1-oxidoreductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3837 ) or ( mll3836 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase subunit III ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOQUINOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOQUINOLIN__45__12H__45__ONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LTARTDEHYDRA__45__RXN" name="L(+)-tartrate dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6099 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarate hydratase, class I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.32</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSENOYLCOARED__45__RXN" name="Trans-2-enoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3093 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__27__45__RXN" name="Methylmalonate-semialdehyde dehydrogenase (acylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3987 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malonic semialdehyde oxidative decarboxylase )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.27</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLORAMPHENICOL__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Chloramphenicol O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr4814 ) or ( mll2311 ) or ( mll4701 ) or ( mlr3351 ) or ( mll1530 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( streptogramin A acetyl transferase ) or ( chloramphenicol acetyltransferase ) or ( chloramphenicol acetyltransferase ) or ( acetyltransferase (virginiamycin, streptogramin A, chloramphenicol) ) or ( acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.28</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLORAMPHENICOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLORAMPHENICOL__45__3__45__ACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__83__45__RXN" name="Dolichyl-phosphate &amp;beta;-D-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8554 ) or ( mlr4737 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE ) or ( dolichol-p-glucose synthetase, (glycosyltransferase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.83</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__RIBULOKIN__45__RXN" name="D-ribulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4918 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribitol kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.47</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3962" name="6-aminohexanoate linear dimer hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2882 ) or ( mll2884 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-aminohexanoate-dimer hydrolase ) or ( 6-aminohexanoate-dimer hydrolase )</html:p>
<html:p>SUBSYSTEM: nylon-6 oligomer degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.46</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__6__45__AMINOHEXANOYL__45__6__45__AMINOHEXANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__884" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="PMPOXI__45__RXN" name="Pyridoxamine-phosphate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7454_pdxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyridoxamine 5&apos;-phosphate oxidase (PNP/PMP oxidase) (PNPOx)//PMPOXI-RXN//PNPOXI-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERATE__45__DEHYDROGENASE__45__RXN" name="Glycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.29</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5073_trpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tryptophan synthase alpha chain//TRYPSYN-RXN//Tryptophan synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: GAP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3963" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2882 ) or ( mll2884 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-aminohexanoate-dimer hydrolase ) or ( 6-aminohexanoate-dimer hydrolase )</html:p>
<html:p>SUBSYSTEM: nylon-6 oligomer degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3923" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__6__45__AMINOHEXANOYL__45__6__45__AMINOHEXANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R544__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__865" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__866" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__13__45__RXN" name="Mannose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6764 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannose-1-phosphate guanyltransferase )</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.13</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8991" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4408_leuD ) or ( mll4272_leuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)//3-ISOPROPYLMALISOM-RXN//3-isopropylmalate dehydratase ) or ( 3-isopropylmalate dehydratase large subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)//3-ISOPROPYLMALISOM-RXN//3-isopropylmalate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9451" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8992" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7442_ubiA ) or ( mlr7426 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase ) or ( octaprenyl-diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URUR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7658 ) or ( mll1631 ) or ( mlr7938 ) or ( mlr0967 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allantoate amidohydrolase ) or ( allantoate amidohydrolase ) or ( allantoate amidohydrolase ) or ( allantoate amidohydrolase )</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate II (ammonia producing)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.-</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__598" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYSYN__45__RXN" name="phosphatidate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.41</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOKETOLASE__45__RXN" name="Phosphoketolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6575 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Probable phosphoketolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__3__46__39__45__RXN" name="4-hydroxy-2-oxovalerate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5426 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-2-oxovalerate aldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.39</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXY__45__2__45__KETOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOADEHYDROG__45__RXN" name="Acyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5624 ) or ( mll5430 ) or ( mll3094 ) or ( mlr5626 ) or ( mlr7452 ) or ( mlr1201 ) or ( mlr5042 ) or ( mlr6975 ) or ( mll0685 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( probable acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( probable acyl-CoA dehydrogenase ) or ( probable acyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBONYL__45__REDUCTASE__45__NADPH__45__RXN" name="Carbonyl reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1884 ) or ( mll4989 ) or ( mll3237 ) or ( mlr5708 ) or ( mll7191 ) or ( mll2196 ) or ( mlr7910 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( short chain dehydrogenase ) or ( short chain dehydrogenase ) or ( short-chain dehydrogenase ) or ( short chain dehydrogenase ) or ( putative oxidoreductase ) or ( probable short chain oxidoreductase ) or ( short chain dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.184</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LONG__45__CHAIN__45__KETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__5__45__EPIMERASE__45__RXN" name="UDP-glucuronate 5&apos;-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6759 ) or ( mlr7549 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative nucleotide sugar epimerase ) or ( nucleotide sugar epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__223" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALISOM__45__RXN" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4408_leuD ) or ( mll4272_leuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydratase small subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)//3-ISOPROPYLMALISOM-RXN//3-isopropylmalate dehydratase ) or ( 3-isopropylmalate dehydratase large subunit (Isopropylmalate isomerase) (Alpha-IPM isomerase) (IPMI)//3-ISOPROPYLMALISOM-RXN//3-isopropylmalate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9451" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R345__45__RXN" name="Adenosylcobyric acid synthase (glutamine-hydrolyzing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1198_cobQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cobyric acid synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__691" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERONE__45__KINASE__45__RXN" name="Glycerone kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr9018 ) or ( mll5296 ) or ( mll7280 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycerone kinase ) or ( dihydroxyacetone kinase ) or ( dihydroxyacetone kinase )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: glycerol degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.29</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STRICTOSIDINE__45__SYNTHASE__45__RXN" name="Strictosidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1724 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( permease protein of sugar ABC transporter )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
      <speciesReference species="SECOLOGANIN__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="STRICTOSIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOPARATHION__45__PHOSPHATASE__45__RXN" name="Aryldialkylphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7664 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to resiniferotoxin-binding, phosphotriesterase-related protein )</html:p>
<html:p>SUBSYSTEM: superpathway of parathion degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__259" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXINE__45__4__45__OXIDASE__45__RXN" name="Pyridoxine 4-oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll6785 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable dehydrogenase )</html:p>
<html:p>SUBSYSTEM: vitamin B6 degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.12</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCPDIESTER__45__RXN" name="Glycerophosphodiester phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr0660 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable phosphodiesterase )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.46</html:p>
<html:p>SIDE: __124__Alcohols__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycerophosphodiesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPNACETYLMURAMATEDEHYDROG__45__RXN" name="UDP-N-acetylmuramate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1552_murB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylenolpyruvoylglucosamine reductase (UDP-N- acetylmuramate dehydrogenase)//UDPNACETYLMURAMATEDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.158</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTODEHYDROG__45__RXN" name="D-galactose 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0280 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactose 1-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: galactose degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.48</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GALACTONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMHYDR__45__RXN" name="Fumarate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll8172_fumC ) or ( mlr6099 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Fumarate hydratase class II (Fumarase C)//FUMHYDR-RXN//Fumarate hydratase ) or ( fumarate hydratase, class I )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETYL__45__COA__45__TRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4181 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetoacetyl-CoA transferase b subunit )</html:p>
<html:p>SUBSYSTEM: acetoacetate degradation (to acetyl CoA)</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTUROISOM__45__RXN" name="Glucuronate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4056_uxaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Uronate isomerase (Glucuronate isomerase) (Uronic isomerase)//GALACTUROISOM-RXN//GLUCUROISOM-RXN//Glucuronate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: D-galacturonate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__TAGATURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRITREDUCT__45__RXN" name="Nitrite reductase (NAD(P)H)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2863 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrite reductase small subunit )</html:p>
<html:p>SUBSYSTEM: nitrate reduction V (assimilatory)</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.4</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NH4OH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ANTHRANSYN__45__RXN" name="Anthranilate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr2774 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anthranilate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.27</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AROMATIC__45__L__45__AMINO__45__ACID__45__DECARBOXYLASE__45__RXN" name="Aromatic-L-amino-acid decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0712 ) or ( mlr4653 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid decarboxylase ) or ( aromatic-L-amino-acid decarboxylase )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VI (via tryptamine)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__LYASE__45__RXN" name="Cystathionine &amp;beta;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll9139 ) or ( mll8145 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-lyase ) or ( cystathionine beta-lyase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.8</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYMALTOPHOSPHORYL__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7586 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5071_trpB ) or ( mlr5073_trpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tryptophan synthase beta chain//RXN0-2382//TRYPSYN-RXN//Tryptophan synthase ) or ( Tryptophan synthase alpha chain//TRYPSYN-RXN//Tryptophan synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMPKI__45__RXN" name="Cytidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5212_cmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cytidylate kinase (CK) (Cytidine monophosphate kinase) (CMP kinase)//CMPKI-RXN//Cytidylate kinase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRS__45__RXN" name="phosphoribosylformylglycinamidine cyclo-ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7962_purM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoribosylformylglycinamidine cyclo-ligase (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase)//AIRS-RXN//Phosphoribosylformylglycinamidine cyclo-ligase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROPRIBTRANS__45__RXN" name="Orotate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll5916_pyrE1 ) or ( mlr7756_pyrE2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Orotate phosphoribosyltransferase 1 (OPRT 1) (OPRTase 1)//Orotate phosphoribosyltransferase ) or ( Orotate phosphoribosyltransferase 2 (OPRT 2) (OPRTase 2)//Orotate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_SUC__45__COA_COF_RXN" name="CO-A_TO_SUC-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PURIDYLTRANS__45__RXN" name="UTP--glucose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5275 ) or ( mll3025 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UTP-glucose-1-phosphate uridylyltransferase exoN ) or ( UTP-glucose-1-phosphate uridylyltransferase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45____45__COA__45__LIGASE__45__RXN" name="Malate--CoA ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr1324_mtkA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Probable malate--CoA ligase subunit beta (Malyl-CoA synthetase) (Malate thiokinase) (MTK-beta) )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__208" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FOLYLPOLYGLUTAMATESYNTH__45__RXN" name="folylpolyglutamate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr5076 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthase (folC) )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDLIPOXN__45__RXN" name="Dihydrolipoamide dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll4470 ) or ( mlr0388 ) or ( mll4296 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrolipoamide dehydrogenase ) or ( dihydrolipoamide dehydrogenase ) or ( dihydrolipoamide dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mll2664 ) or ( mlr7635 ) or ( mll9205 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase ) or ( aminotransferase ) or ( branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__884" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr7502_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN//RXN0-884//4-hydroxy-3-methylbut-2-enyl diphosphate reductase )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HCAMULTI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILO0235_hcaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylpropionate dioxygenase, ferredoxin subunit )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.19</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__PHENYLPROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYETHYL__45__3__45__5__45__CYCLOHEXADIENE__45__1__45__2__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7442_ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__8186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8192" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__882" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll3792_ispG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1- hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)//RXN0-882//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Protein__45__Disulfides__124__</html:p>
<html:p>SIDE: __124__Protein__45__Dithiols__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__58__45__RXN" name="Phenylalanine(histidine) aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll0405 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.58</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3443" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll7045 ) or ( mll2867 ) or ( mll1015 ) or ( mlr3049 ) or ( mlr5236 ) or ( mll2219 ) or ( mll3072 ) or ( mll4783 ) or ( mll6639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( NADP-dependent aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase ) or ( dehydrogenase, (succinatesemialdehyde dehydrogenase, aldehyde dehydrogenase, aldehyde dehydrogenase) ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMUR__45__ALA__45__LIG__45__RXN" name="UDP-N-acetylmuramate--alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1553_murC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramate--L-alanine ligase (UDP-N- acetylmuramoyl-L-alanine synthetase)//UDP-NACMUR-ALA-LIG-RXN//UDP-N-acetylmuramate--L-alanine ligase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__ACETYLMURAMOYL__45__ALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHYLGLYCINE__45__DEHYDROGENASE__45__RXN" name="Dimethylglycine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mll1517 ) or ( mlr1213 ) or ( mll2449 ) or ( mll1653 ) or ( mll1258 ) or ( mlr1280 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable dimethylglycine dehydrogenase ) or ( sarcosine dehydrogenase ) or ( dimethylglycine dehydrogenase ) or ( dimethylglycine dehydrogenase ) or ( sarcosine dehydrogenase ) or ( dimethylglycine dehydrogenase precursor )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
