<?xml version="1.0"  encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="RHILE109_metabolic_network_metabolic_network" name="Rhizobium leguminosarum">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
  <species id="CPD__45__107" name="6-hydroxypseudooxynicotine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUCURONATE" name="glucuronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" name="hydroxymethylpyrimidine phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__106" name="(S)-4-Hydroxymandelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__105" name="(R)-4-Hydroxymandelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__313" name="1,3-diaminopropane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Monophosphates__124__" name="a ribonucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__XYLULOSE" name="L-xylulose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DIHYDROXY__45__PHENYLALANINE" name="L-dopa" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Phospholipid__45__Cyclopropane__45__Fatty__45__Acids__124__" name="a phospholipid cyclopropane fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7224" name="N-acetyl-L-citrulline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBON__45__MONOXIDE" name="CO" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Amino__45__Acids__124__" name="a D-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="E__45__" name="e-" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEHYDRO__45__DEOXY__45__GALACTONATE__45__PHOSPHATE" name="2-dehydro-3-deoxy-D-galactonate-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GAMMA__45__GLUTAMYLCYSTEINE" name="L-&amp;gamma;-glutamylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP" name="GDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1086" name="5-amino-6-(5&apos;-phosphoribitylamino)uracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" name="an L-1-phosphatidyl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="APS" name="adenosine 5&apos;-phosphosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SEDOHEPTULOSE__45__7__45__P" name="D-sedoheptulose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__110" name="salicylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__111" name="3-methylcatechol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROFOLATE" name="7,8-dihydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acceptor__124__" name="an oxidized electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ILE" name="L-isoleucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINAMINE" name="S-adenosyl-L-methioninamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARG" name="L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__IDONATE" name="L-idonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GALACTURONATE" name="galacturonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__CHLORO__45__24__45__DINITROBENZENE" name="1-chloro-2,4-dinitrobenzene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BISOHMYR__45__GLC" name="lipid A disaccharide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__882" name="1,6-anhMurNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMP" name="inosine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TARTRONATE__45__S__45__ALD" name="tartronate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CROTONOBETAINYL__45__COA" name="crotonobetainyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6972" name="4-(2&apos;-carboxyphenyl)-4-oxobutyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATRAZINE" name="atrazine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__ETCETERA__45__GLUCOSAMINYLDIPHOSPHOUND" name="prenyl-P-P-GlcNAc-ManNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7418" name="coumarinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7417" name="coumarinic acid-&amp;beta;-D-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ" name="2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ALLANTOIN" name="S-allantoin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__104" name="reduced pyrroloquinoline-quinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__335" name="(R)-3-hydroxybutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__ARYL__45__2__45__METHYLMALONATE" name="2-aryl-2-methylmalonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" name="4-amino-4-deoxychorismate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__D__45__GLUCOSE" name="GDP-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOAMIDE" name="lipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" name="a protein L-&amp;beta;-isoaspartate &amp;alpha;-methyl ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" name="formyl-L-methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ASPARTATE" name="L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="E__45__37__45__DIMETHYLOCTA__45__16__45__DIEN__45__38__45__DIOL" name="(E)-3,7-dimethylocta-1,6-dien-3,8-diol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALONATE__45__S__45__ALD" name="malonate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BENZOATE" name="benzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__8" name="ubiquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__9" name="ubiquinone-9" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACRYLATE" name="acrylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Donor__45__H2__124__" name="a reduced electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CYSTATHIONINE" name="cystathionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BENZOYLSUCCINYL__45__COA" name="benzoylsuccinyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" name="6,7-dimethyl-8-(1-D-ribityl)lumazine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL" name="pyridoxal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" name="D-myo-inositol (3)-monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TREHALOSE__45__6P" name="trehalose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" name="2-octaprenyl-6-hydroxyphenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__15__45__BISPHOSPHATE" name="ribose-1,5-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__FORMYLMETHIONINE" name="N-formyl-L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATP" name="ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" name="UDP-N-acetyl-D-galactosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__OXALOCITRAMALATE" name="4-oxalocitramalate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALYL__45__COA" name="oxalyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYDROXYMUCONATE__45__SALD" name="2-hydroxymuconate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Long__45__Chain__45__Polyphosphate__124__" name="long chain polyphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MG__45__PROTOPORPHYRIN" name="Mg-protoporphyrin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSE" name="&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__318" name="monodehydroascorbate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7000" name="isobutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOLLATE" name="glycolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH__45__P__45__OR__45__NOP" name="NAD(P)H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="T2__45__DECENOYL__45__COA" name="trans-&amp;Delta;2-decenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__121" name="(R)-mandelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" name="dTDP-4-dehydro-6-deoxy-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__122" name="(S)-mandelate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDPDIACYLGLYCEROL" name="a CDP-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXYADIPYL__45__COA" name="3-hydroxyadipyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__LACTATE" name="D-lactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Monophosphates__124__" name="a nucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8199" name="a mismatched DNA base pair" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4822" name="kanamycin B" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__CHLOROETHANOL" name="2-chloroethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" name="a 2,3,4-saturated fatty acyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__352" name="estradiol-17&amp;beta;" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__METHYL__45__MYO__45__INOSITOL" name="D-ononitol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Methanofurans__124__" name="methanofuran" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__PROPIONYL__45__COA" name="3-hydroxypropionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CANAVANINE" name="canavanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__1__45__ARSENATE" name="ribose-1-arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROKAEMPFEROL__45__CMPD" name="dihydrokaempferol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__3__45__HYDROXYACYL__45__COA" name="a (3S)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARSENATE" name="arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TYR" name="L-tyrosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5678__45__TETRAHYDROPTERIDINE" name="5,6,7,8-tetrahydropteridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETO__45__6__45__AMINO__45__CAPROATE" name="2-keto-6-aminocaproate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" name="3-deoxy-D-arabino-heptulosonate-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE" name="N-acetyl-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THREO__45__DS__45__ISO__45__CITRATE" name="D-isocitrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LYS" name="L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENYLOSUCC" name="adenylo-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8181" name="DNA with lesion resolved through Rec-mediated pathway" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8180" name="DNA with lesion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__343" name="3-deoxy-D-glycero-2,5-hexodiulosonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__AP__45__Site__45__Created__124__" name="an AP(apurinic or apyrimidinic) site created by glycosylic bond cleavage" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUMP" name="dUMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1242" name="3-keto-&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1241" name="D-galactose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALO__45__SUCCINATE" name="oxalosuccinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" name="4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOPORPHYRIN_IX" name="protoporphyrin IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KDO__45__8P" name="3-deoxy-D-manno-octulosonate 8-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALLO__45__THR" name="allothreonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__371" name="1-octanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UROPORPHYRINOGEN__45__III" name="uroporphyrinogen-III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C4" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl- D-alanyl-D-alanine-diphosphoundecaprenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C3" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C6" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OH__45__MYRISTOYL" name="UDP-2,3-bis(3-hydroxymyristoyl)glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C5" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptane-D-alanyl-D-alanine-diphosphoundecaprenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROPIONYL__45__P" name="propionyl-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCERATE" name="D-glycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__377" name="2-dehydro-D-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7035" name="2-phenylethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIETHYLTHIOPHOSPHATE" name="diethylthiophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7037" name="methionol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7036" name="3-methylthiopropanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__MERCAPTO__45__PYRUVATE" name="3-mercaptopyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7031" name="3-methylbutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7032" name="isoamyl alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7033" name="2-methylbutanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2K__45__ADIPATE" name="&amp;alpha;-ketoadipate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__Ala__45__L__45__Glu" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Phospholipid__45__Olefinic__45__Fatty__45__Acids__124__" name="a phospholipid olefinic fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__369" name="L-iditol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__DEHYDROGLUCONATE" name="5-ketogluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C1" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate- D-alanyl-D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Beta__45__D__45__Galactosides__124__" name="a &amp;beta;-D-galactoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANOSINE__45__5DP__45__3DP" name="guanosine 5&apos;-diphosphate,3&apos;-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__365" name="2-keto-myo-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__METHYLBENZYL__45__ALCOHOL" name="3-methylbenzyl alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__367" name="L-sulfolactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BISOHMYR__45__GLUCOSAMINYL__45__1P" name="2,3-bis(3-hydroxymyristoyl)-&amp;beta;-D-glucosaminyl 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" name="1-(o-carboxyphenylamino)-1&apos;-deoxyribulose-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRANS__45__POLYISOPRENYL__45__PP" name="a trans-polyisoprenyln-PP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Amineated__45__Amine__45__Donors__124__" name="an amineated amine donor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXY__45__ACETONE__45__PHOSPHATE" name="dihydroxy-acetone phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Triphosphates__124__" name="a nucleoside triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__358" name="D-lactaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYDROXYMETHYLBILANE" name="hydroxymethylbilane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="ETHYLENE__45__CMPD" name="ethylene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8624" name="peptidylproline (&amp;omega; = 180)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8625" name="peptidylproline (&amp;omega; = 0)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DCTP" name="dCTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHYLENETETRAHYDROMETHANOPTERIN" name="5,10-methylene-tetrahydromethanopterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYNUCLEOTIDESM" name="(deoxynucleotides)(m)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
</listOfSpecies>
<listOfReactions>
  <reaction id="AKBLIG__45__RXN" name="Glycine C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3641_kbl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase)//AKBLIG-RXN )</html:p>
<html:p>SUBSYSTEM: threonine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.29</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GST__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3338_gst ) or ( RHILE2125_yfcG ) or ( RHILE2944 ) or ( RHILE2810 ) or ( RHILE1512 ) or ( RHILE4922 ) or ( RHILE0304 ) or ( p11RHILE0498 ) or ( p10RHILE0369 ) or ( RHILE1282 ) or ( RHILE1531 ) or ( RHILE1416_gst ) or ( RHILE0929_yfcG ) or ( RHILE1431 ) or ( RHILE0346 ) or (  ) or ( RHILE3197 ) or ( RHILE1363 ) or ( p11RHILE0332 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathionine S-transferase//GST-RXN ) or ( putative glutathione S-transferase enzyme with thioredoxin-like domain ) or ( putative GLUTATHIONE S-TRANSFERASE PROTEIN (EC 2.5.1.18) ) or ( putative Glutathione transferase//Glutathione transferase ) or ( GstA protein ) or ( putative glutathione S-transferase ) or ( putative GLUTATHIONE S-TRANSFERASE PROTEIN (EC 2.5.1.18) ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative Glutathione transferase//Glutathione transferase ) or ( putative gst14 glutatione S-transferase (EC 2.5.1.18) ) or ( glutathionine S-transferase//GST-RXN ) or ( putative glutathione S-transferase enzyme with thioredoxin-like domain ) or ( Glutathione S-transferase family protein ) or ( putative glutathione S-transferase ) or ( PUTATIVE GLUTATHIONE S-TRANSFERASE PROTEIN (EC 2.5.1.18) (fragment) ) or ( Glutathione S-transferase ) or ( putative GLUTATHIONE S-TRANSFERASE PROTEIN (EC 2.5.1.18) ) or ( putative glutathione S-transferase P subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__CHLORO__45__24__45__DINITROBENZENE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="S__45__24__45__DINITROPHENYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3428_ilvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ketol-acid reductoisomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDHDEHYDROG__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p8RHILE0077 ) or ( p12RHILE0665_aldH ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__68__45__RXN" name="5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0050 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative enzyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.68</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__785" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__786" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEXENEDIOATE__45__AUTOTRANSFORMATION__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__185" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R547__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__868" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__869" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRAISOM__45__RXN" name="Phosphoribosylanthranilate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0020_trpF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative N-(5&apos;-phosphoribosyl)anthranilate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.24</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENETHFDEHYDROG__45__NADP__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0783_folD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN )</html:p>
<html:p>SUBSYSTEM: reductive acetyl coenzyme A pathway</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__NH3__45__RXN" name="GMP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0266 ) or ( RHILE0333_guaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative GMP synthase (glutamine-hydrolyzing)//GMP synthase (glutamine-hydrolyzing) ) or ( GMP synthetase (glutamine aminotransferase)//GMP-SYN-GLUT-RXN//GMP-SYN-NH3-RXN//GMP synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLGLUCOSAMINE__45__KINASE__45__RXN" name="N-acetylglucosamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0263 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative N-acetylglucosamine kinase (EC 2.7.1.59)//N-acetylglucosamine kinase )</html:p>
<html:p>SUBSYSTEM: chitobiose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.59</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSLIG__45__RXN" name="Phosphopantothenate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0377_dfp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: 4&apos;-phosphopantothenoylcysteine decarboxylase; phosphopantothenoylcysteine synthetase, FMN-binding//P-PANTOCYSDECARB-RXN//P-PANTOCYSLIG-RXN )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTRACE__45__RXN" name="Glutamate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2804_murI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glutamate racemase//GLUTRACE-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKYLGLYCERONE__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="Alkylglycerone-phosphate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0325 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Alkylglycerone-phosphate synthase//Alkylglycerone-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.26</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__a__45__long__45__chain__45__alcohol__124__" stoichiometry="1"/>
      <speciesReference species="_1__45__ACYL__45__GLYCERONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="_1__45__ALKYL__45__GLYCERONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__761" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0531_otsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate synthase//TREHALOSE6PSYN-RXN )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__151__45__RXN" name="N-acetyllactosaminide &amp;alpha;-1,3-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3901 ) or ( RHILE3677 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative galactosyl transferase PssJ ) or ( Galactosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.87</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATE__45__SYNTHASE__45__RXN" name="Chorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1057_aroC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chorismate synthase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.5</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTODEG__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0762 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 4-alpha-glucanotransferase//4-alpha-glucanotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__40__glucose__41__m" stoichiometry="1"/>
      <speciesReference species="__40__glucose__41__n" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__40__glucose__41__n__43__m__45__1" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLHOMOSER__45__CYS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1782 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative O-acetylhomoserine sulfhydrylase )</html:p>
<html:p>SUBSYSTEM: homocysteine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.49</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__2__45__HYDROXY__45__ACID__45__DEHYDROGENASE__45__RXN" name="D-2-hydroxy-acid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0248 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative D-isomer specific 2-hydroxyacid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.6</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HIPPURATE__45__HYDROLASE__45__RXN" name="Hippurate hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0249 ) or ( RHILE4156 ) or ( RHILE4653 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hippurate hydrolase ) or ( Hippurate hydrolase (EC 3.5.1.32) (Benzoylglycine amidohydrolase) (Hippuricase)//Hippurate hydrolase ) or ( hippurate hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.32</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__425" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__3__45__DEHYDROGENASE__45__RXN" name="Carnitine 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3567_caiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-carnitine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: carnitine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.108</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DE__45__H__45__CARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROCANATE__45__HYDRATASE__45__RXN" name="Urocanate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0385 ) or ( p11RHILE0220 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Urocanate hydratase (EC 4.2.1.49) (Urocanase) (Imidazolonepropionate hydrolase)//Urocanate hydratase ) or ( Urocanate hydratase (EC 4.2.1.49) (Urocanase) (Imidazolonepropionate hydrolase)//Urocanate hydratase )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.49</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROCANATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__3__45__PHOSPHATE__45__DEHYDROGENASE__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0082_glpD ) or ( p12RHILE0211_glpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sn-glycerol-3-phosphate dehydrogenase FAD/NAD(P)-binding (aerobic)//GLYC3PDEHYDROG-RXN//RXN0-5258 ) or ( sn-glycerol-3-phosphate dehydrogenase FAD/NAD(P)-binding (aerobic)//GLYC3PDEHYDROG-RXN//RXN0-5258 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCISOM__45__RXN" name="Xylose isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4458_xylA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-xylose isomerase//XYLISOM-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSE6PSYN__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0531_otsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate synthase//TREHALOSE6PSYN-RXN )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.15</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTEROATESYNTH__45__RXN" name="Dihydropteroate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2828_folP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydropteroate synthase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.15</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXY__45__2__45__KETOPIMELATE__45__LYSIS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0469 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.-</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__804" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CPM__45__KDOSYNTH__45__RXN" name="3-deoxy-manno-octulosonate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0147_kdsB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CTP:CMP-3-deoxy-D-manno-octulosonate transferase//CPM-KDOSYNTH-RXN )</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.38</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="KDO" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLN_TO_GLT_COF_RXN" name="GLN_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAICARSYN__45__RXN" name="Phosphoribosylaminoimidazole-succinocarboxamide synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2778_purC ) or ( RHILE4140 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase)//SAICARSYN-RXN ) or ( putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2 (EC 6.3.2.6) (SAICAR synthetase 2) )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCDIAMINOPIMDESUCC__45__RXN" name="Succinyl-diaminopimelate desuccinylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0459_dapE ) or ( RHILE0163 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-succinyl-diaminopimelate deacylase//SUCCDIAMINOPIMDESUCC-RXN ) or ( putative peptidase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.18</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__SUCCINYLLL__45__2__45__6__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMYLOMALT__45__RXN" name="4-&amp;alpha;-glucanotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0762 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 4-alpha-glucanotransferase//4-alpha-glucanotransferase )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATPPHOSPHORIBOSYLTRANS__45__RXN" name="ATP phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0926 ) or ( RHILE0927 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP phosphoribosyltransferase regulatory subunit ) or ( ATP phosphoribosyltransferase (EC 2.4.2.17) (ATP-PRTase) (ATP-PRT)//ATP phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.17</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP_TO_GDP__45__MANNOSE_COF_RXN" name="GDP_TO_GDP-MANNOSE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINE__45__NUCLEOSIDASE__45__RXN" name="Uridine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0404_rihA ) or ( p12RHILE0180_rihA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleoside hydrolase 1, pyrimidine-specific ) or ( ribonucleoside hydrolase 1, pyrimidine-specific )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4281" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2977_yghZ ) or ( RHILE4852_dkgA ) or ( RHILE3468_yeaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase ) or ( 2,5-diketo-D-gluconate reductase A//1.1.1.274-RXN//RXN0-1941 ) or ( putative oxidoreductase, NAD(P)-linked )</html:p>
<html:p>SUBSYSTEM: acetone degradation I (to methylglyoxal)</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__HEXAPRENYLTRANSTRANSFERASE__45__RXN" name="trans-hexaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0988_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.30</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R314__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2201_GatA2 ) or ( p9RHILE0215 ) or ( p11RHILE0464 ) or ( RHILE0232 ) or ( p12RHILE0140 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( putative amidase ) or ( Glutamyl-tRNA amidotransferase subunit A ) or ( putative amidase ) or ( putative AMIDASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: aldoxime degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AGMATIN__45__RXN" name="Agmatinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2579 ) or ( RHILE1772_speB ) or ( p10RHILE0400 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative agmatinase ) or ( agmatinase ) or ( Agmatinase, mitochondrial precursor (EC 3.5.3.11) (Agmatine ureohydrolase) (AUH)//Agmatinase )</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine degradation III (arginine decarboxylase/agmatinase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AGMATHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOLACTOSE__45__RXN" name="&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3322 ) or ( p9RHILE0136 ) or ( RHILE4063 ) or ( RHILE4530 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Beta-D-galactosidase ) or ( putative Beta-galactosidase//Beta-galactosidase ) or ( putative Beta-galactosidase//Beta-galactosidase ) or ( Beta-galactosidase (EC 3.2.1.23) (Lactase)//Beta-galactosidase )</html:p>
<html:p>SUBSYSTEM: lactose degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOLACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1242" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__271__45__RXN" name="GDP-L-fucose synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0141_fcl ) or ( RHILE0871_fcl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase; GDP-4-dehydro-6-L-deoxygalactose reductase ) or ( bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase; GDP-4-dehydro-6-L-deoxygalactose reductase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.271</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTODEXGLUCOSID__45__RXN" name="&amp;alpha;-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3785 ) or ( RHILE0788 ) or ( p12RHILE0747 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alpha-glucosidase (EC 3.2.1.20) ) or ( putative alpha-glucosidase (EC 3.2.1.20) ) or ( putative ALPHA-AMYLASE-RELATED PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__PENTAPRENYLTRANSFERASE__45__RXN" name="Trans-pentaprenyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0988_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.33</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDRODIPICSYN__45__RXN" name="dihydrodipicolinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4777 ) or ( p10RHILE0295 ) or ( p12RHILE0559 ) or ( RHILE1920 ) or (  ) or ( p9RHILE0108 ) or ( p11RHILE0029 ) or ( RHILE4715 ) or ( p12RHILE0346 ) or ( RHILE3840 ) or ( RHILE1593_dapA ) or ( p12RHILE0004 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydrodipicolinate synthase (EC 4.2.1.52)//Dihydrodipicolinate synthase ) or ( putative dihydrodipicolinate synthetase ) or ( putative Dihydrodipicolinate synthase//Dihydrodipicolinate synthase ) or ( MosA protein (EC 4.1.-.-) ) or ( Putative dihydrodipicolinate synthetase protein (EC 4.2.1.52) (fragment) ) or ( Dihydrodipicolinate synthase 1 (EC 4.2.1.52)//Dihydrodipicolinate synthase ) or ( putative Dihydrodipicolinate synthase (EC 4.2.1.52) (DHDPS)//Dihydrodipicolinate synthase ) or ( putative dihydrodipicoline synthase related protein ) or ( Dihydrodipicolinate synthase family protein//Dihydrodipicolinate synthase ) or ( putative Dihydrodipicolinate synthase//Dihydrodipicolinate synthase ) or ( dihydrodipicolinate synthase ) or ( putative Dihydrodipicolinate synthase//Dihydrodipicolinate synthase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.52</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCOSE_TO_UDP_COF_RXN" name="UDP-GLUCOSE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDP__45__GLUCOSE__45__46__45__DEHYDRATASE__45__RXN" name="CDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0259_rfbG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cdp-glucose 4,6-dehydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__658" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0353 ) or ( RHILE4327_ggt ) or ( RHILE4873 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative gamma-glutamyltranspeptidase ) or ( gamma-glutamyltranspeptidase//GAMMA-GLUTAMYLTRANSFERASE-RXN ) or ( putative Gamma-glutamyltransferase//Gamma-glutamyltransferase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
      <speciesReference species="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__1__45__DEHYDROGENASE__45__RXN" name="Glucose 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2911 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glucose 1-dehydrogenase II (EC 1.1.1.47) (GLCDH-II) )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.47</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG6PDEACET__45__RXN" name="N-acetylglucosamine-6-phosphate deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4897 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)//N-acetylglucosamine-6-phosphate deacetylase )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine , N-acetylmannosamine and N-acetylneuraminic acid dissimilation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__GLU__45__AMINOTRANSFORASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4676 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine aminotransferase 3 (EC 2.6.1.11) (ACOAT 3) )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXY__45__OXOHEPT__45__ENEDIOATE__45__DECARBOXY__45__RXN" name="5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0050 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative enzyme )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.68</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__785" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__787" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSNACMURPENTATRANS__45__RXN" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3540_mraY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospho-N-acetylmuramoyl-pentapeptide transferase//PHOSNACMURPENTATRANS-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: UNDECAPRENYL__45__P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
      <speciesReference species="C1" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C5" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMPCYCLOHYDROLASE__45__RXN" name="IMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5017_purH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal)//AICARTRANSFORM-RXN//IMPCYCLOHYDROLASE-RXN//IMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__23__45__RXN" name="Carboxyvinyl-carboxyphosphonate phosphorylmutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4756 ) or ( RHILE0466 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative carboxyphosphonoenolpyruvate phosphonomutase ) or ( putative Carboxyvinyl-carboxyphosphonate phosphorylmutase//Carboxyvinyl-carboxyphosphonate phosphorylmutase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.23</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__CARBOXYVINYL__45__CARBOXYPHOSPHONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROHYDROXYPHOSPHORYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPXPRIBOSYLTRAN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2067_gpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine-hypoxanthine phosphoribosyltransferase//XANPRIBOSYLTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__99__46__4__45__RXN" name="1-aminocyclopropane-1-carboxylate deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0097 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-aminocyclopropane-1-carboxylate deaminase (EC 3.5.99.7) (ACC deaminase) (ACCD)//1-aminocyclopropane-1-carboxylate deaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__68" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1382" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0025 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative formyl-CoA transferase, NAD(P)-binding )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALATE" stoichiometry="1"/>
      <speciesReference species="FORMYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALYL__45__COA" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNP__45__RXN" name="Purine-nucleoside phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0208_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENMETSYN__45__RXN" name="Methionine adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0410_metK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methionine adenosyltransferase 1 (AdoMet synthetase)//S-ADENMETSYN-RXN )</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: ethylene biosynthesis from methionine</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANIDINOBUTANAMIDE__45__NH3__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2201_GatA2 ) or ( p9RHILE0215 ) or ( p11RHILE0464 ) or ( RHILE0232 ) or ( p12RHILE0140 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( putative amidase ) or ( Glutamyl-tRNA amidotransferase subunit A ) or ( putative amidase ) or ( putative AMIDASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: arginine degradation X (arginine monooxygenase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__GUANIDO__45__BUTYRAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__592" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R22__45__RXN" name="Butyryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0626 ) or ( p9RHILE0255 ) or ( RHILE1016 ) or ( p10RHILE0332 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acyl-CoA dehydrogenase ) or ( putative FMNH2-dependent monooxygenase ) or ( putative acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__DEHYDROPANTOATE__45__REDUCT__45__RXN" name="2-dehydropantoate 2-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1923 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-dehydropantoate 2-reductase (EC 1.1.1.169) (Ketopantoate reductase) (KPA reductase) (KPR)//2-dehydropantoate 2-reductase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.169</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOX__45__RXN" name="Sarcosine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3548 ) or ( RHILE4778 ) or ( p11RHILE0604_soxA ) or ( RHILE4403_soxA ) or ( RHILE0794 ) or ( RHILE4406_soxB ) or ( p12RHILE0655 ) or ( p11RHILE0602_soxB ) or ( p12RHILE0639 ) or ( RHILE3547 ) or ( RHILE4881 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Sarcosine oxidase//Sarcosine oxidase ) or ( putative Sarcosine oxidase//Sarcosine oxidase ) or ( sarcosine oxidase (alpha subunit) oxidoreductase protein ) or ( sarcosine oxidase (alpha subunit) oxidoreductase protein ) or ( putative oxidoreductase ordL (EC 1.-.-.-) ) or ( sarcosine oxidase beta subunit ) or ( putative Oxidoreductase ) or ( sarcosine oxidase beta subunit ) or ( putative deaminase ) or ( putative Sarcosine oxidase//Sarcosine oxidase ) or ( putative Sarcosine oxidase//Sarcosine oxidase )</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNITOL__45__2__45__DEHYDROGENASE__45__RXN" name="Mannitol 2-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4496 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mannitol 2-dehydrogenase (EC 1.1.1.67) (MDH)//Mannitol 2-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.67</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDEHYDE__45__OXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p12RHILE0665_aldH ) or ( p8RHILE0077 ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__358" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADOMET__45__DMK__45__METHYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0392_ubiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase; S-adenosylmethionine:2-DMK methyltransferase )</html:p>
<html:p>SUBSYSTEM: menaquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEMETHYLMENAQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VITAMIN_K_2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHELENE__45__THMPT__45__OXI__45__RXN" name="Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0312 ) or ( p9RHILE0259 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductase ) or ( putative coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.11</html:p>
<html:p>COFACTOR: __124__Factor__45__420__124__</html:p>
<html:p>COFACTOR: __124__Reduced__45__Factor__45__F420__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENETETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYL__45__THMPT" stoichiometry="1"/>
      <speciesReference species="__124__Oxidized__45__Factor__45__F420__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__II__45__RXN" name="GTP cyclohydrolase II" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1056_ribB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative GTP cyclohydrolase II, riboflavin biosynthesis//GTP cyclohydrolase II )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.25</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0585_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: transcriptional repressor of proline utilization; proline dehydrogenase; pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7784" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0322 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cinnamoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.219</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7087" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7088" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0585_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: transcriptional repressor of proline utilization; proline dehydrogenase; pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSOPHOSPHOLIPASE__45__RXN" name="Lysophospholipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4823_tesA ) or ( RHILE4368 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: acyl-CoA thioesterase I; protease I; lysophospholipaseL(I)//LYSOPHOSPHOLIPASE-RXN ) or ( putative lysophospholipase L2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__GLYCERO__45__PHOSPHORYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHACYL__45__COA__45__DEHYDROG__45__RXN" name="3-hydroxyacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0330 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-hydroxyacyl-CoA dehydrogenase//3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CINNAMOYL__45__COA__45__REDUCTASE__45__RXN" name="Cinnamoyl-CoA reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0322 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cinnamoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.44</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CINNAMALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CINNAMOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="EXOPOLYPHOSPHATASE__45__RXN" name="Exopolyphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1694 ) or ( RHILE0889 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative exopolyphosphatase ) or ( putative exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETPYRKIN__45__RXN" name="Hydroxymethylpyrimidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0478_thiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase)//OHMETPYRKIN-RXN//PYRIMSYN3-RXN )</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.49</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__9__45__RXN" name="Glyceraldehyde-3-phosphate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4280_epd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-erythrose 4-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.9</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__262__45__RXN" name="4-hydroxythreonine-4-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0105 ) or ( RHILE1657_pdxA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxythreonine-4-phosphate dehydrogenase 2 (EC 1.1.1.262) (4- (phosphohydroxy)-L-threonine dehydrogenase 2)//4-hydroxythreonine-4-phosphate dehydrogenase ) or ( NAD-dependent dehydrogenase/carboxylase, pyridoxine phosphate biosynthetic protein PdxJ-PdxA subunit//1.1.1.262-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.262</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOSINE__45__NUCLEOSIDASE__45__RXN" name="Inosine nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4150 ) or ( RHILE3014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative inosine-uridine preferring nucleoside hydrolase protein ) or ( putative Purine nucleosidase//Purine nucleosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UPPSYN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2360_ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)//RXN0-5180 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CIS__45__TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOCHLOROPHYLLIDE__45__REDUCTASE__45__RXN" name="Protochlorophyllide reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1469 ) or ( RHILE0511 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxidoreductase (EC 1.-.-.-) ) or ( putative Protochlorophyllide reductase//Protochlorophyllide reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.33</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MONO__45__VINYL__45__PROTOCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0394 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Cystathionine gamma-synthase//Cystathionine gamma-synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__69__45__RXN" name="Protein-N(PI)-phosphohistidine-sugar phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0448 ) or ( p11RHILE0412 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative NITROGEN REGULATORY IIA PROTEIN (EC 2.7.1.69) ) or ( Phosphotransferase enzyme IIA (EC 2.7.1.69) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sugar__124__" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
      <speciesReference species="__124__Sugar__45__Phosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" name="L-ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATE__45__REDUCTASE__45__NADPORNOPH__45__RXN" name="Nitrate reductase (NAD(P)H)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3222 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Nitrate reductase (NADPH)//Nitrate reductase (NADPH) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0398_hemN2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxygen-independent coproporphyrinogen III oxidase (hemN) )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.22</html:p>
<html:p>SIDE: CH33ADO</html:p>
<html:p>SIDE: MET</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVIN__45__SYN__45__RXN" name="Riboflavin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1729_ribE ) or ( RHILE1718_ribC ) or ( RHILE3372 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( riboflavin synthase, beta chain ) or ( riboflavin synthase alpha chain ) or ( 6,7-dimethyl-8-ribityllumazine synthase (EC 2.5.1.9) (DMRL synthase) (Lumazine synthase) (Riboflavin synthase beta chain)//Riboflavin synthase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP_TO_UTP_COF_RXN" name="UDP_TO_UTP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R11__45__RXN" name="Acetate CoA-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1932 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Acetyl-CoA-transferase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRIC_ACID" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETATE__45____45__COA__45__LIGASE__45__RXN" name="Acetoacetate--CoA ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0810 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetoacetyl-coenzyme A synthetase (EC 6.2.1.16) (Acetoacetate--CoA ligase 1) (Acyl-activating enzyme 1)//Acetoacetate--CoA ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.16</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_THF_COF_RXN" name="METHYLENE-THF_TO_THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0024_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: folylpolyglutamate synthase; dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__1__46__11__45__RXN" name="Phenylalanine racemase (ATP-hydrolysing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative non-ribosomal peptide synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.11</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__216" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IGPSYN__45__RXN" name="indole-3-glycerol-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2655_trpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indole-3-glycerol phosphate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.48</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Ubiquinones__124___TO___124__Ubiquinols__124___COF_RXN" name="|Ubiquinones|_TO_|Ubiquinols|_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Ubiquinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ubiquinols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THI__45__P__45__KIN__45__RXN" name="Thiamine-phosphate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0695 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Thiamine-phosphate kinase//Thiamine-phosphate kinase )</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.16</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE_TO_UDP_COF_RXN" name="UDP-GLUCURONATE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__24__45__RXN" name="Phosphatidylcholine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2519 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphatidylcholine synthase (EC 2.7.8.24) (CDP-diglyceride-choline O- phosphatidyltransferase) (PC synthase)//Phosphatidylcholine synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.24</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7781" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4925_ispA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase (=farnesyldiphosphate synthase)//FPPSYN-RXN//GPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6721" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DALADEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3115 ) or ( RHILE0827 ) or ( RHILE0504 ) or ( p12RHILE0441_dadA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative D-amino acid dehydrogenase subunit ) or ( putative D-amino-acid dehydrogenase//D-amino-acid dehydrogenase ) or ( putative D-amino-acid dehydrogenase//D-amino-acid dehydrogenase ) or ( D-amino acid dehydrogenase subunit//DAADEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: alanine degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7780" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4925_ispA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase (=farnesyldiphosphate synthase)//FPPSYN-RXN//GPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6722" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_DIHYDROFOLATE_COF_RXN" name="METHYLENE-THF_TO_DIHYDROFOLATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__METHYLCITRATE__45__DEHYDRATASE__45__RXN" name="2-methylcitrate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0523 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-methylcitrate dehydratase//2-methylcitrate dehydratase )</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.79</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__622" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1136" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UGD__45__RXN" name="UDP-glucose 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0058 ) or ( RHILE3920 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative nucleotide sugar oxidase protein ) or ( putative UDP-glucose 6-dehydrogenase//UDP-glucose 6-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERCAPYSTRANS__45__RXN" name="3-mercaptopyruvate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2097_sseA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-mercaptopyruvate sulfurtransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCN" stoichiometry="1"/>
      <speciesReference species="_3__45__MERCAPTO__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HSCN" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYL__45__ALCOHOL__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Aryl-alcohol dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1606 ) or ( RHILE0293 ) or ( RHILE2421 ) or ( RHILE0921 ) or ( RHILE3187 ) or ( p11RHILE0579 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Oxidoreductase, aldo/keto reductase family protein ) or ( putative Aryl-alcohol dehydrogenase (NADP+) ) or ( Voltage-gated potassium channel beta-2 subunit (K(+) channel beta-2 subunit) (Kv-beta-2) (HKvbeta2) ) or ( Oxidoreductase (modular protein) ) or ( putative aldoketoreductase ) or ( putative oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.91</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__Aldehyde__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4113" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0328 ) or ( p12RHILE0464 ) or ( p9RHILE0032_adhP ) or ( RHILE1990 ) or ( p10RHILE0115 ) or ( p10RHILE0129 ) or ( RHILE1407 ) or ( p9RHILE0106 ) or ( p10RHILE0148 ) or ( p12RHILE0555_adhC ) or (  ) or ( p12RHILE0636 ) or ( RHILE3574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alcohol dehydrogenase, propanol-preferring ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase, propanol-preferring//ALCOHOL-DEHYDROG-GENERIC-RXN//ALCOHOL-DEHYDROG-RXN ) or ( putative Zn-containing alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase ) or ( putative OXIDOREDUCTASE TRANSMEMBRANE PROTEIN ) or ( Alcohol dehydrogenase (EC 1.1.1.1)//Alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase class III ) or ( putative iron-containing alcohol dehydrogenase (fragment) ) or ( Alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDRPHENYLAC__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__4151" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROLINE__45__MULTI" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4977_proB ) or ( RHILE4978_proA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamate kinase//GLUTKIN-RXN ) or ( gamma-glutamylphosphate reductase//GLUTSEMIALDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTAMINOTRANS__45__RXN" name="Histidinol-phosphate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4622_hisC ) or ( RHILE4926_hisC ) or ( RHILE1572 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative histidinol-phosphate aminotransferase//HISTAMINOTRANS-RXN ) or ( histidinol-phosphate aminotransferase//HISTAMINOTRANS-RXN ) or ( putative Histidinol-phosphate transaminase//Histidinol-phosphate transaminase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.9</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALGLDAPLIG__45__RXN" name="UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3542_murE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4830_acnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitate hydratase 1//ACONITATEDEHYDR-RXN//ACONITATEHYDR-RXN )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYXK__45__RXN" name="L-xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0801 ) or ( p12RHILE0203 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative L-xylulose kinase protein (EC 2.7.1.53) ) or ( putative carbohydrate kinase )</html:p>
<html:p>SUBSYSTEM: L-lyxose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.53</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__XYLULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDYLATE__45__SYNTHASE__45__RXN" name="Pseudouridylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4137 ) or ( RHILE0457 ) or ( RHILE2734_rluC ) or ( RHILE0941 ) or ( RHILE0128_truB ) or ( RHILE4025_rluD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Pseudouridylate synthase//Pseudouridylate synthase ) or ( tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA-uridine isomerase I) (tRNA pseudouridylate synthase I) ) or ( 23S rRNA pseudouridylate synthase ) or ( putative Pseudouridylate synthase//Pseudouridylate synthase ) or ( tRNA pseudouridine 5S synthase ) or ( pseudouridine synthase (pseudouridines 1911, 1915, 1917 in 23S RNA) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.70</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIACYLGLYCEROL__45__LIPASE__45__RXN" name="Triacylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0023 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative lipase/esterase )</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Fatty__45__Acids__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Diacylglycerides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHOSINEPHOSPHORY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0208_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7779" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4925_ispA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase (=farnesyldiphosphate synthase)//FPPSYN-RXN//GPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6643" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SALICYLATE__45__1__45__MONOOXYGENASE__45__RXN" name="Salicylate 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2342 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Salicylate 1-monooxygenase//Salicylate 1-monooxygenase )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__110" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7143" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4925_ispA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase (=farnesyldiphosphate synthase)//FPPSYN-RXN//GPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6644" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4925_ispA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase (=farnesyldiphosphate synthase)//FPPSYN-RXN//GPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6642" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCUROISOM__45__RXN" name="Glucuronate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0102 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Uronate isomerase (EC 5.3.1.12) (Glucuronate isomerase) (Uronic isomerase)//Glucuronate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4898 ) or ( p12RHILE0259 ) or ( RHILE2531_glmS ) or ( p10RHILE0198_glmS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NagB, glucosamine-fructose-6-phosphate aminotransferase ) or ( putative Glutamine--fructose-6-phosphate transaminase (isomerizing)//Glutamine--fructose-6-phosphate transaminase (isomerizing) ) or ( L-glutamine:D-fructose-6-phosphate aminotransferase//L-GLN-FRUCT-6-P-AMINOTRANS-RXN ) or ( L-glutamine:D-fructose-6-phosphate aminotransferase//L-GLN-FRUCT-6-P-AMINOTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.16</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__HYDRAT__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1964 ) or ( p12RHILE0535_hcaA ) or ( RHILE1778 ) or ( RHILE1933_dcaE ) or ( RHILE0394_paaF ) or ( RHILE0641 ) or ( p12RHILE0178 ) or ( p12RHILE0072_paaF ) or ( RHILE1017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Enoyl-CoA hydratase//Enoyl-CoA hydratase ) or ( enoyl-CoA hydratase/lyase ) or ( putative enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase protein (EC 4.2.1.17) ) or ( putative dihydroxynaphthoic acid synthetase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLGLUTKIN__45__RXN" name="Acetylglutamate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0468_argB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acetylglutamate kinase//ACETYLGLUTKIN-RXN )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULOKIN__45__RXN" name="L-ribulokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4494 ) or ( p9RHILE0126 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative SUGAR KINASE PROTEIN (EC 2.7.1.-) ) or ( Ribitol kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.16</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribulose__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribulose__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7562" name="Acetylornithine aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4676 ) or ( RHILE0582_argD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine aminotransferase 3 (EC 2.6.1.11) (ACOAT 3) ) or ( acetylornithine transaminase (NAcOATase and DapATase), PLP-dependent//ACETYLORNTRANSAM-RXN//SUCCINYLDIAMINOPIMTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.11</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__264__45__RXN" name="L-idonate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0426_idnD ) or ( p10RHILE0424_idnD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-idonate 5-dehydrogenase, NAD-binding ) or ( L-idonate 5-dehydrogenase, NAD-binding )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>SUBSYSTEM: L-idonate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.264</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__IDONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__DEHYDROGLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__3__46__9__45__RXN" name="Phosphoenolpyruvate--protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4567_ptsP ) or ( RHILE3102 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrogen regulatory protein PTSI(NTR) ) or ( Phosphoenolpyruvate-protein phosphotransferase (EC 2.7.3.9) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.3.9</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXI__45__RXN" name="Lactoylglutathione lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2226 ) or ( RHILE0537 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative lactoylglutathione lyase ) or ( LACTOYLGLUTATHIONE LYASE (EC 4.4.1.5) )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.5</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8675" name="Uroporphyrinogen-III C-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2429 ) or ( RHILE3013 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative siroheme synthetase ) or ( Uroporphyrin-III C-methyltransferase (EC 2.1.1.107) (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM) )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8674" name="Glycine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3835 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glycine oxidase//Glycine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ethylglycine" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
      <speciesReference species="ETHANAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__NUCLEOSID__45__RXN" name="AMP nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1566_amn )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AMP nucleosidase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE__45__5P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENDECARBOX__45__RXN" name="Uroporphyrinogen decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5038_hemE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen decarboxylase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.37</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DSERDEAM__45__RXN" name="D-serine ammonia-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0455 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-serine deaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIMSYN3__45__RXN" name="Phosphomethylpyrimidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0478_thiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase)//OHMETPYRKIN-RXN//PYRIMSYN3-RXN )</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.7</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYM__45__PHOSPH__45__RXN" name="Thymidine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0210_deoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine phosphorylase//THYM-PHOSPH-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="THYMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTONDEHYDRAT__45__RXN" name="Galactonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4131 ) or ( RHILE4115 ) or ( RHILE0966_dgoA ) or ( RHILE4515_dgoD ) or ( p12RHILE0823 ) or ( p12RHILE0619 ) or ( p12RHILE0822 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Galactonate dehydratase//Galactonate dehydratase ) or ( putative Galactonate dehydratase ) or ( bifunctional: 2-dehydro-3-deoxygalactonate 6-phosphate aldolase (N-terminal); galactonate dehydratase (C-terminal)//DEHYDDEOXPHOSGALACT-ALDOL-RXN ) or ( Galactonate dehydratase ) or ( putative Galactonate dehydratase//Galactonate dehydratase ) or ( putative Galactonate dehydratase//Galactonate dehydratase ) or ( putative isomerase )</html:p>
<html:p>SUBSYSTEM: D-galactonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GALACTONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETATE__45__DECARBOXYLASE__45__RXN" name="Acetoacetate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0183 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acetoacetate decarboxylase 2 (EC 4.1.1.4) (ADC 2) (AAD 2) )</html:p>
<html:p>SUBSYSTEM: acetone degradation I (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.4</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPSYN__45__RXN" name="Tryptophan synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0021_trpB ) or ( RHILE0022_trpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase, beta protein//RXN0-2382//TRYPSYN-RXN ) or ( tryptophan synthase, alpha protein//TRYPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANIDINOBUTYRASE__45__RXN" name="Guanidinobutyrase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4747_gbh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanidinobutyrase )</html:p>
<html:p>SUBSYSTEM: arginine degradation X (arginine monooxygenase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.7</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__592" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TSA__45__REDUCT__45__RXN" name="2-hydroxy-3-oxopropionate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4062_glxR ) or ( RHILE4034_glxR ) or ( RHILE2957 ) or ( p10RHILE0428 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tartronic semialdehyde reductase//TSA-REDUCT-RXN ) or ( tartronic semialdehyde reductase//TSA-REDUCT-RXN ) or ( 3-hydroxyisobutyrate dehydrogenase ) or ( putative 2-hydroxy-3-oxopropionate reductase//2-hydroxy-3-oxopropionate reductase )</html:p>
<html:p>SUBSYSTEM: D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.60</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7958" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2003 ) or ( RHILE4170 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetate kinase (EC 2.7.2.1) (Acetokinase)//Acetate kinase ) or ( Acetate kinase (EC 2.7.2.1) (Acetokinase)//Acetate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1673_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0328 ) or ( p12RHILE0464 ) or ( p9RHILE0032_adhP ) or ( RHILE1990 ) or ( p10RHILE0115 ) or ( p10RHILE0129 ) or ( RHILE1407 ) or ( p9RHILE0106 ) or ( p10RHILE0148 ) or ( p12RHILE0555_adhC ) or (  ) or ( p12RHILE0636 ) or ( RHILE3574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alcohol dehydrogenase, propanol-preferring ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase, propanol-preferring//ALCOHOL-DEHYDROG-GENERIC-RXN//ALCOHOL-DEHYDROG-RXN ) or ( putative Zn-containing alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase ) or ( putative OXIDOREDUCTASE TRANSMEMBRANE PROTEIN ) or ( Alcohol dehydrogenase (EC 1.1.1.1)//Alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase class III ) or ( putative iron-containing alcohol dehydrogenase (fragment) ) or ( Alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to ethanol I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__20" name="Magnesium chelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0089 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative protoporphyrin IX magnesium chelatase bchO )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.6.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: MG__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MG__43__2" stoichiometry="1"/>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MG__45__PROTOPORPHYRIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANDELATE__45__RACEMASE__45__RXN" name="Mandelate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0245 ) or ( p11RHILE0641 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative mandelate racemase ) or ( Mandelate racemase/muconate lactonizing enzyme domain protein//Mandelate racemase )</html:p>
<html:p>SUBSYSTEM: mandelate degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__121" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__122" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__87__45__RXN" name="N-carbamoyl-L-amino-acid hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0388 ) or ( p12RHILE0161 ) or ( RHILE3971 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-carbamoyl-L-amino acid amidohydrolase (EC 3.5.1.-) ) or ( Peptidase, M20/M25/M40 family ) or ( putative N-CARBAMYL-L-AMINO ACID AMIDOHYDROLASE PROTEIN (EC 3.5.1.-) (L-N-carbamoylase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.87</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Carbamoyl__45__L__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__2__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPYRIMIDINASE__45__RXN" name="Dihydropyrimidinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3974 ) or ( RHILE4781 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-hydantoinase (EC 3.5.2.2) (Dihydropyrimidinase) (DHPase)//Dihydropyrimidinase ) or ( D-hydantoinase (EC 3.5.2.2) (Dihydropyrimidinase) (DHPase)//Dihydropyrimidinase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CREATINASE__45__RXN" name="Creatinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0319 ) or ( p12RHILE0056 ) or ( RHILE4428 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative creatine amidohydrolase ) or ( Hypothetical hydrolase/peptidase y4tM (EC 3.-.-.-) (modular protein) ) or ( putative creatine amidohydrolase )</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CREATINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGINASE__45__RXN" name="Arginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4675_rocF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative arginase )</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation VII (arginase 3 pathway)</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMDECARB__45__RXN" name="Diaminopimelate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4609_lysA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaminopimelate decarboxylase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.20</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLATECYC__45__RXN" name="Adenylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1696 ) or ( RHILE2596 ) or ( RHILE4386 ) or ( RHILE0485 ) or ( RHILE2668 ) or ( RHILE3154 ) or (  ) or ( RHILE3389 ) or ( RHILE3151 ) or ( RHILE1189 ) or ( RHILE4409 ) or ( p11RHILE0117 ) or ( p11RHILE0069 ) or ( RHILE2463 ) or ( p11RHILE0618 ) or (  ) or ( RHILE1206 ) or ( RHILE1294 ) or ( p11RHILE0198 ) or ( RHILE4539 ) or ( RHILE1255 ) or ( RHILE1414 ) or ( RHILE3024 ) or ( RHILE4408 ) or ( p11RHILE0389 ) or ( RHILE3500 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenylate cyclase 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2)//Adenylate cyclase ) or ( putative Adenylate cyclase//Adenylate cyclase ) or ( putative adenylate cyclase 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) ) or ( putative adenylate cyclase protein (EC 4.6.1.1) ) or ( putative Adenylate cyclase//Adenylate cyclase ) or ( putative adenylate cyclase ) or ( putative ADENYLATE/GUANYLATE CYCLASE PROTEIN (EC 4.6.1.1) (fragment) ) or ( putative adenylate cyclase protein (EC 4.6.1.1) ) or ( putative adenylate cyclase 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) ) or ( putative adenylate cyclase 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) ) or ( putative Adenylate/Guanylate cyclase ) or ( putative Adenylate cyclase//Adenylate cyclase ) or ( putative Adenylate cyclase//Adenylate cyclase ) or ( putative Adenylate cyclase//Adenylate cyclase ) or ( putative CyaF4 adenylate cyclase ) or ( putative Adenylate/Guanylate cyclase (fragment) ) or ( putative Adenylate cyclase ) or ( putative Adenylate cyclase 1 (EC 4.6.1.1) (ATP pyrophosphate-lyase 1) (Adenylyl cyclase 1)//Adenylate cyclase ) or ( putative Adenylate cyclase//Adenylate cyclase ) or ( putative adenylate cyclase protein (EC 4.6.1.1) ) or ( putative adenylate cyclase 3 (EC 4.6.1.1) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) ) or ( putative Adenylate/Guanylate cyclase ) or ( putative Adenylate/guanylate cyclase ) or ( putative Adenylate cyclase//Adenylate cyclase ) or ( putative Adenylate cyclase//Adenylate cyclase ) or ( putative ADENYLATE/GUANYLATE CYCLASE TRANSMEMBRANE PROTEIN (EC 4.6.1.1) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASCORBATE__45__OXIDASE__45__RXN" name="L-ascorbate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2589 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative copper-containing oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASCORBATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8670" name="Pentachlorophenol monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2467 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative monooxygenase ) or ( Putative oxygenase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.50</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__44__3__44__5__44__6__45__tetrachlorophenol" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRACHLOROHYDROQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACSERLY__45__RXN" name="Cysteine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0359_cysK ) or ( RHILE2099 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of cysteine synthase A and O-acetylserine sulfhydrolase A, PLP-dependent enzyme//ACSERLY-RXN ) or ( O-acetylserine (thiol) lyase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.47</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8672" name="Glycine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3835 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glycine oxidase//Glycine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8673" name="Glycine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3835 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glycine oxidase//Glycine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLAMINE" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCHOMOSERLYASE__45__RXN" name="O-succinylhomoserine (thiol)-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0587_metZ ) or ( p12RHILE0394 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-succinylhomoserine sulfhydrylase ) or ( putative Cystathionine gamma-synthase//Cystathionine gamma-synthase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.48</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIB5PISOM__45__RXN" name="Ribose 5-phosphate epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2881_cbbI ) or ( RHILE2713_rpiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose 5-phosphate isomerase ) or ( ribose 5-phosphate isomerase B, also acts as allose 6-phosphate isomerase//RIB5PISOM-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__8__46__1__46__8__45__RXN" name="Atrazine chlorohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0074 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Atrazine chlorohydrolase//Atrazine chlorohydrolase )</html:p>
<html:p>SUBSYSTEM: atrazine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATRAZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYATRAZINE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCDEHYDROG__45__RXN" name="Glucose dehydrogenase (pyrroloquinoline-quinone)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3683_yliI ) or ( RHILE1437_gcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dehydrogenase with soluble quinoprotein glucose dehydrogenase domain ) or ( glucose dehydrogenase//GLUCDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.5.2</html:p>
<html:p>COFACTOR: __124__Ubiquinols__124__</html:p>
<html:p>COFACTOR: __124__Ubiquinones__124__</html:p>
<html:p>SIDE: __124__Ubiquinols__124__</html:p>
<html:p>SIDE: __124__Ubiquinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CELLULOSE__45__SYNTHASE__45__GDP__45__FORMING__45__RXN" name="Cellulose synthase (GDP-forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1745 ) or ( RHILE0591 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cellulose synthase ) or ( putative cellulose synthase protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.29</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CELLULOSE" stoichiometry="1"/>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__O__45__ACETTRAN__45__RXN" name="Serine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2345_cysE ) or ( RHILE4433_cysE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine acetyltransferase//SERINE-O-ACETTRAN-RXN ) or ( serine acetyltransferase//SERINE-O-ACETTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.30</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDINE__45__AMMONIA__45__LYASE__45__RXN" name="Histidine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0232 ) or ( p12RHILE0787 ) or ( p11RHILE0222 ) or ( RHILE0390 ) or ( RHILE4763 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Histidine ammonia-lyase ) or ( Histidine ammonia-lyase ) or ( Histidine ammonia-lyase (EC 4.3.1.3) (Histidase)//Histidine ammonia-lyase ) or ( putative Histidine ammonia-lyase//Histidine ammonia-lyase ) or ( Histidine ammonia-lyase 2 (EC 4.3.1.3) (Histidase 2)//Histidine ammonia-lyase )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.3</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROCANATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPOXANPRIBOSYLTRAN__45__RXN" name="Hypoxanthine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4612 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) (HPRT)//Hypoxanthine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__121__45__RXN" name="Phosphoenolpyruvate--glycerone phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0409_dhaL ) or ( RHILE1859_dhaL ) or ( p12RHILE0410_dhaK ) or ( RHILE1856_dhaK ) or ( RHILE3104_dhaK ) or ( RHILE3099_dhaL ) or ( RHILE1857_dhaL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dihydroxyacetone kinase ) or ( putative dihydroxyacetone kinase ) or ( putative dihydroxyacetone kinase ) or ( putative dihydroxyacetone kinase ) or ( putative dihydroxyacetone kinase ) or ( putative dihydroxyacetone kinase ) or ( putative dihydroxyacetone kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.121</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONDEHYDROG__45__RXN" name="Phosphogluconate dehydrogenase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4271_gnd ) or ( RHILE2996_gnd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase//6PGLUCONDEHYDROG-RXN ) or ( gluconate-6-phosphate dehydrogenase, decarboxylating//6PGLUCONDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0379_panC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantothenate synthetase//PANTOATE-BETA-ALANINE-LIG-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOYL__45__LACTONE" stoichiometry="1"/>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7933" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0668 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine deacetylase (EC 3.5.1.16)//Acetylornithine deacetylase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7224" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAADEHYDROG__45__RXN" name="D-amino-acid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3115 ) or ( RHILE0827 ) or ( RHILE0504 ) or ( p12RHILE0441_dadA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative D-amino acid dehydrogenase subunit ) or ( putative D-amino-acid dehydrogenase//D-amino-acid dehydrogenase ) or ( putative D-amino-acid dehydrogenase//D-amino-acid dehydrogenase ) or ( D-amino acid dehydrogenase subunit//DAADEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUGAR__45__PHOSPHATASE__45__RXN" name="Sugar-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1750_yfbT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphatase, contains a phosphatase-like domain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.23</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sugar__45__Phosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Sugar__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOACYLASE__45__RXN" name="Aminoacylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0514_abgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative peptidase, p-aminobenzoyl-glutamate utilization, with Zn-dependent exopeptidase domain and carboxypeptidase G2, dimerisation domain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.14</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Acylated__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__L__45__Amino__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYBENZALDEHYDE__45__OXIDATION__45__NAD__45__RXN" name="Benzaldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0517_hcaB ) or ( p12RHILE0524_hcaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxybenzaldehyde dehydrogenase ) or ( hydroxybenzaldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.28</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXYBENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__73__45__RXN" name="Feruloyl esterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2143 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative POLYHYDROXYALKANOATE DEPOLYMERASE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.73</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Feruloyl__45__polysaccharides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
      <speciesReference species="__124__Polysaccharides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7706" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0328 ) or ( p12RHILE0464 ) or ( p9RHILE0032_adhP ) or ( RHILE1990 ) or ( p10RHILE0115 ) or ( p10RHILE0129 ) or ( RHILE1407 ) or ( p9RHILE0106 ) or ( p10RHILE0148 ) or ( p12RHILE0555_adhC ) or (  ) or ( p12RHILE0636 ) or ( RHILE3574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alcohol dehydrogenase, propanol-preferring ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase, propanol-preferring//ALCOHOL-DEHYDROG-GENERIC-RXN//ALCOHOL-DEHYDROG-RXN ) or ( putative Zn-containing alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase ) or ( putative OXIDOREDUCTASE TRANSMEMBRANE PROTEIN ) or ( Alcohol dehydrogenase (EC 1.1.1.1)//Alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase class III ) or ( putative iron-containing alcohol dehydrogenase (fragment) ) or ( Alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7036" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7037" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANINE__45__DEAMINASE__45__RXN" name="Guanine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0076 ) or ( RHILE3823_guaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Guanine deaminase//Guanine deaminase ) or ( guanine deaminase )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINE__45__OXIDASE__45__FLAVIN__45__CONTAINING__45__RXN" name="Amine oxidase (flavin-containing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0193 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Amine oxidase (flavin-containing)//Amine oxidase (flavin-containing) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYL__45__KIN__45__RXN" name="Guanylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1655_gmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanylate kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7700" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0328 ) or ( p12RHILE0464 ) or ( p9RHILE0032_adhP ) or ( RHILE1990 ) or ( p10RHILE0115 ) or ( p10RHILE0129 ) or ( RHILE1407 ) or ( p9RHILE0106 ) or ( p10RHILE0148 ) or ( p12RHILE0555_adhC ) or (  ) or ( p12RHILE0636 ) or ( RHILE3574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alcohol dehydrogenase, propanol-preferring ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase, propanol-preferring//ALCOHOL-DEHYDROG-GENERIC-RXN//ALCOHOL-DEHYDROG-RXN ) or ( putative Zn-containing alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase ) or ( putative OXIDOREDUCTASE TRANSMEMBRANE PROTEIN ) or ( Alcohol dehydrogenase (EC 1.1.1.1)//Alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase class III ) or ( putative iron-containing alcohol dehydrogenase (fragment) ) or ( Alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7035" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPDEHYRHAMREDUCT__45__RXN" name="dTDP-4-dehydrorhamnose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1720_rfbD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TDP-rhamnose synthetase, NAD(P)-binding )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.133</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__RHAMNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7908" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4820_phhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.96</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIOHBUTANONEPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2910_ribB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,4 dihydroxy-2-butanone-4-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__BUTANONE__45__P" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1673_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMACETOXID__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3244 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Copper methylamine oxidase precursor (EC 1.4.3.6) (MAOXII) )</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7710" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2564 ) or ( p12RHILE0749_glgB ) or ( RHILE4394_glgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 1,4-alpha-glucan branching enzyme//1,4-alpha-glucan branching enzyme ) or ( 1,4-alpha-glucan branching enzyme ) or ( 1,4-alpha-glucan branching enzyme )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4714 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-pyrone-4,6-dicarboxylate hydrolase )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation I (meta-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.57</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__184" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__OXALOMESACONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3283" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0320_hyfB ) or ( p11RHILE0318_hyfE ) or ( p11RHILE0319_hycD ) or ( p11RHILE0317_hyfF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydrogenase 4, B membrane subunit ) or ( hydrogenase 4, E (membrane) subunit ) or ( hydrogenase 3, membrane subunit (part of FHL complex) ) or ( hydrogenase 4, F membrane subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="E__45__" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__5__45__DEHYDROGENASE__45__RXN" name="Shikimate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0084 ) or ( RHILE0003_aroE ) or ( RHILE3038 ) or ( RHILE3036 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Shikimate dehydrogenase family protein//Shikimate dehydrogenase ) or ( putative Shikimate dehydrogenase//Shikimate dehydrogenase ) or ( putative dehydroshikimate reductase, NAD(P)-binding ) or ( Shikimate dehydrogenase (EC 1.1.1.25)//Shikimate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.25</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__132__45__RXN" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0675_cobL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative precorrin 6y methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.132</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__679" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__686" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__ISOPROPYLMALATESYN__45__RXN" name="2-isopropylmalate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3752_leuA ) or ( RHILE1629_leuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-isopropylmalate synthase ) or ( putative isopropyl malate synthase//2-ISOPROPYLMALATESYN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.13</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2463" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0289_ligJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-oxalomesaconate hydratase )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation I (meta-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__OXALOMESACONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__OXALOCITRAMALATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5285" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1469 ) or ( RHILE0511 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxidoreductase (EC 1.-.-.-) ) or ( putative Protochlorophyllide reductase//Protochlorophyllide reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.33</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIVINYL__45__PROTOCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIVINYLCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5284" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0464 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase (EC 1.14.13.81) (Mg-protoporphyrin IX monomethyl ester oxidative cyclase) )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_131__45__OXO__45__MAGNESIUM__45__PROTOPORPHYRIN__45__IX__45__13__45__M" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIVINYL__45__PROTOCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0464 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase (EC 1.14.13.81) (Mg-protoporphyrin IX monomethyl ester oxidative cyclase) )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_13__45__HYDROXY__45__MAGNESIUM__45__PROTOPORP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_131__45__OXO__45__MAGNESIUM__45__PROTOPORPHYRIN__45__IX__45__13__45__M" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7911" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0536 ) or ( p12RHILE0550 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2,4-dienoyl-CoA reductase (NADPH)//2,4-dienoyl-CoA reductase (NADPH) ) or ( putative N-methylproline demethylase (EC 1.-.-.-) (Stachydrine utilization protein stcD) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRADEHYDROACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0464 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase (EC 1.14.13.81) (Mg-protoporphyrin IX monomethyl ester oxidative cyclase) )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MG__45__PROTOPORPHYRIN__45__MONOMETHYL__45__ESTER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_13__45__HYDROXY__45__MAGNESIUM__45__PROTOPORP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMEPIM__45__RXN" name="Diaminopimelate epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4840_dapF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaminopimelate epimerase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7919" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4624 ) or ( RHILE1197 ) or ( RHILE3264 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glyoxalase II ) or ( putative Hydroxyacylglutathione hydrolase//Hydroxyacylglutathione hydrolase ) or ( putative Hydroxyacylglutathione hydrolase//Hydroxyacylglutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__hydroxyacyl__45__glutathiones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Hydroxy__45__carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7913" name="Cytidylate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0110_cmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine monophosphate (CMP) kinase//CMPKI-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYISOVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0246 ) or ( RHILE4713_ilvD3 ) or ( RHILE1912_ilvD ) or ( RHILE4033_ilvD1 ) or ( RHILE3860 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Dihydroxy-acid dehydratase//Dihydroxy-acid dehydratase ) or ( dihydroxy-acid dehydratase ) or ( dihydroxyacid dehydratase//DIHYDROXYISOVALDEHYDRAT-RXN//DIHYDROXYMETVALDEHYDRAT-RXN ) or ( dihydroxy-acid dehydratase ) or ( putative dihydroxy-acid dehydratase protein (EC 4.2.1.9) )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PENTACHLOROPHENOL__45__MONOOXYGENASE__45__RXN" name="Pentachlorophenol monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2467 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative monooxygenase ) or ( Putative oxygenase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.50</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PENTACHLOROPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRACHLOROHYDROQUINONE" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETHYLBILANESYN__45__RXN" name="Hydroxymethylbilane synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4789_hemC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxymethylbilane synthase (porphobilinogen deaminase)//OHMETHYLBILANESYN-RXN )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.61</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DURIDKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3773_tdk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine kinase//DURIDKI-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLCROTONYL__45__COA__45__CARBOXYLASE__45__RXN" name="Methylcrotonyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0324 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acyl-CoA carboxylase biotin-carrying subunit )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__157__45__RXN" name="Glucosamine-1-phosphate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2530_glmU ) or ( RHILE0868 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal)//NAG1P-URIDYLTRANS-RXN ) or ( Acetyltransferase )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.157</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCOSAMINE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINOALANINE__45__AMINOTRANSFERASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3680_aatA ) or ( RHILE3475 ) or ( p10RHILE0399 ) or ( RHILE4764_aspC ) or ( p10RHILE0064_aspC ) or ( RHILE0867 ) or ( RHILE0638 ) or ( p12RHILE0297 ) or ( RHILE2784 ) or ( p10RHILE0466_aatA ) or ( p12RHILE0433_aatA ) or ( RHILE2217 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate aminotransferase A ) or ( putative GntR-family regulatory protein ) or ( putative AMINOTRANSFERASE PROTEIN (EC 2.6.1.-) ) or ( aspartate aminotransferase, PLP-dependent//ASPAMINOTRANS-RXN ) or ( aspartate aminotransferase, PLP-dependent//ASPAMINOTRANS-RXN ) or ( Pleiotropic regulatory protein ) or ( putative Aspartate transaminase//Aspartate transaminase ) or ( putative Aspartate transaminase//Aspartate transaminase ) or ( putative TRANSCRIPTION REGULATOR PROTEIN ) or ( aspartate aminotransferase A ) or ( aspartate aminotransferase A ) or ( putative aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.1</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSCHOL__45__RXN" name="Phospholipase D" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0777 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phospholipase D (EC 3.1.4.4)//Phospholipase D )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CHOLINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__19__45__RXN" name="3-phosphoshikimate 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0996 ) or ( RHILE0111_aroA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-phosphoshikimate 1-carboxyvinyltransferase//3-phosphoshikimate 1-carboxyvinyltransferase ) or ( 3-phosphoshikimate 1-carboxyvinyltransferase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.19</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__58__45__RXN" name="Lipopolysaccharide glucosyltransferase I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3677 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Galactosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.58</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Lipopolysaccharides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8523" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5108" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1686_yffH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( conserved hypothetical protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BADH__45__RXN" name="Betaine-aldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1350_betB ) or ( RHILE1934 ) or ( p11RHILE0187_betB ) or ( p11RHILE0164 ) or ( RHILE2930 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+-dependent betaine aldehyde dehydrogenase//BADH-RXN ) or ( Betaine aldehyde dehydrogenase (EC 1.2.1.8) (BADH) ) or ( NAD+-dependent betaine aldehyde dehydrogenase//BADH-RXN ) or ( aldehyde dehydrogenase ) or ( putative ly membrane-anchored aldehyde dehydrogenase protein (EC 1.2.1.3) )</html:p>
<html:p>SUBSYSTEM: choline degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis I (Gram-negative bacteria)</html:p>
<html:p>SUBSYSTEM: choline-O-sulfate degradation</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis II (Gram-positive bacteria)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPH__45__RXN" name="Phosphoglycolate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0953 ) or ( RHILE2733 ) or ( RHILE3623 ) or ( RHILE2883_cbbZ ) or ( RHILE1114 ) or ( RHILE4495 ) or ( p9RHILE0124 ) or ( RHILE0273 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Phosphoglycolate phosphatase//Phosphoglycolate phosphatase ) or ( putative phosphoglycolate phosphatase protein ) or ( putative L-2-haloalkanoic acid dehalogenase ) or ( phosphoglycolate phosphatase ) or ( putative Phosphoglycolate phosphatase//Phosphoglycolate phosphatase ) or ( putative Phosphoglycolate phosphatase//Phosphoglycolate phosphatase ) or ( PUTATIVE HYDROLASE PHOSPHATASE PROTEIN (modular protein) ) or ( putative Phosphoglycolate phosphatase//Phosphoglycolate phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__67" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__83__45__RXN" name="D-malate dehydrogenase (decarboxylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0163_yeaU ) or ( p12RHILE0664_yeaU ) or ( RHILE1045_yeaU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative tartrate dehydrogenase ) or ( putative tartrate dehydrogenase ) or ( putative tartrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.83</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__660" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOTHENATE__45__KIN__45__RXN" name="Pantothenate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0040_coaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantothenate kinase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGEN__45__BRANCH__45__RXN" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2564 ) or ( p12RHILE0749_glgB ) or ( RHILE4394_glgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 1,4-alpha-glucan branching enzyme//1,4-alpha-glucan branching enzyme ) or ( 1,4-alpha-glucan branching enzyme ) or ( 1,4-alpha-glucan branching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENODEAMIN__45__RXN" name="Adenosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0213 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase)//Adenosine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5101" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3669_nemA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-ethylmaleimide reductase, FMN-linked )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.-.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ETHYLMALEIMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__903" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINEOXID__45__RXN" name="Amine oxidase (copper-containing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3244 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Copper methylamine oxidase precursor (EC 1.4.3.6) (MAOXII) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__44__45__RXN" name="Homospermidine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4349 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homospermidine synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.44</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1821" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__CH3__45__2__45__OXOBUTANOATE__45__OH__45__CH3__45__XFER__45__RXN" name="3-methyl-2-oxobutanoate hydroxymethyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0380_panB ) or ( p11RHILE0668 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methyl-2-oxobutanoate hydroxymethyltransferase ) or ( putative 3-methyl-2-oxobutanoate hydroxymethyltransferase//3-methyl-2-oxobutanoate hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.11</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: METHYLENE__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYLPHOSPHATASE__45__RXN" name="Aryldialkylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0233 ) or ( RHILE3340 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Aryldialkylphosphatase//Aryldialkylphosphatase ) or ( putative Aryldialkylphosphatase//Aryldialkylphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Dialkyl__45__Phosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
      <speciesReference species="__124__Dialkyl__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE__45__CARBOXYLASE__45__RXN" name="Pyruvate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4935 ) or ( RHILE2725 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyruvate carboxylase (EC 6.4.1.1) (Pyruvic carboxylase) (PYC)//Pyruvate carboxylase ) or ( propionyl-CoA carboxylase precursor, biotin carrier protein )</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTCYCLOHYD__45__RXN" name="Phosphoribosyl-AMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2697_his3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosyl c-AMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R321__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0680 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-3B synthase (EC 1.14.13.83)//Precorrin-3B synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.83</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__642" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__643" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__LACTAMASE__45__RXN" name="&amp;beta;-lactamase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3381_ampC ) or ( RHILE0623 ) or ( p11RHILE0640 ) or ( RHILE1435_penP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-lactamase/D-ala carboxypeptidase; penicillin resistance, penicillin-binding protein (PBP)//BETA-LACTAMASE-RXN ) or ( putative Beta-lactamase//Beta-lactamase ) or ( putative Beta-lactamase//Beta-lactamase ) or ( putative Beta-lactamase//Beta-lactamase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__Lactams__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8550" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__99__46__4__45__RXN" name="&amp;alpha;-methylacyl-CoA racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3567_caiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-carnitine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__2__45__METHYLACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__2__45__METHYLACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARABISOM__45__RXN" name="L-arabinose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0670 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative L-arabinose isomerase protein )</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__RIBULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R542__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0328 ) or ( p12RHILE0464 ) or ( p9RHILE0032_adhP ) or ( RHILE1990 ) or ( p10RHILE0115 ) or ( p10RHILE0129 ) or ( RHILE1407 ) or ( p9RHILE0106 ) or ( p10RHILE0148 ) or ( p12RHILE0555_adhC ) or (  ) or ( p12RHILE0636 ) or ( RHILE3574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alcohol dehydrogenase, propanol-preferring ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase, propanol-preferring//ALCOHOL-DEHYDROG-GENERIC-RXN//ALCOHOL-DEHYDROG-RXN ) or ( putative Zn-containing alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase ) or ( putative OXIDOREDUCTASE TRANSMEMBRANE PROTEIN ) or ( Alcohol dehydrogenase (EC 1.1.1.1)//Alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase class III ) or ( putative iron-containing alcohol dehydrogenase (fragment) ) or ( Alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__863" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__864" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__45__45__RXN" name="Aminocarboxymuconate-semialdehyde decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2499 ) or ( p12RHILE0223 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Aminocarboxymuconate-semialdehyde decarboxylase//Aminocarboxymuconate-semialdehyde decarboxylase ) or ( Thermophilic reversible gamma-resorcylate decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__3__45__OXOPROP__45__2__45__ENYL__45__BUT__45__2__45__ENEDI" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UREIDOGLYCOLATE__45__LYASE__45__RXN" name="Ureidoglycolate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3830_allA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ureidoglycolate amidohydrolase(decarboxylating)//UREIDOGLYCOLATE-HYDROLASE-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation (E. coli)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate III</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.3</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEPHOSPHOCOAKIN__45__RXN" name="Dephospho-CoA kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0004_coaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dephospho-CoA kinase CoaE//DEPHOSPHOCOAKIN-RXN )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0952 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-deoxy-D-manno-octulosonic-acid transferase )</html:p>
<html:p>SUBSYSTEM: KDO transfer to lipid IVA</html:p>
<html:p>PROTEIN_CLASS: 2.-.-.-</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LIPID__45__IV__45__A" stoichiometry="1"/>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO__45__LIPID__45__IVA" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPACYLGLCNACDEACETYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3527_lpxC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-3-O-acyl N-acetylglucosamine deacetylase )</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__OHMYR__45__ACETYLGLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="UDP__45__OHMYR__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULP3EPIM__45__RXN" name="ribulose phosphate 3-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2770_rpe ) or ( p12RHILE0034 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-ribulose-5-phosphate 3-epimerase//RIBULP3EPIM-RXN ) or ( Ribulose-5-phosphate 3-epimerase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: ribitol degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__5__46__1__45__RXN" name="Nitrilase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0698 ) or ( p8RHILE0083 ) or ( p12RHILE0465 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aliphatic nitrilase (EC 3.5.5.7) ) or ( putative nitrilase ) or ( Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase//Nitrilase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nitriles__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCPHOSDIESTER__45__RXN" name="2&apos;,3&apos;-cyclic-nucleotide 2&apos;-phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2080_cpdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2&apos;:3&apos;-cyclic-nucleotide 2&apos;-phosphodiesterase//CYCPHOSDIESTER-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.16</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__2__45__3__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINKIN__45__RXN" name="Riboflavin kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0935_ribF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: flavokinase; FAD synthetase//FADSYN-RXN//RIBOFLAVINKIN-RXN//FAD synthetase )</html:p>
<html:p>SUBSYSTEM: 5,6-dimethylbenzimidazole biosynthesis</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R123__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0324 ) or ( p11RHILE0656 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cytosine deaminase ) or ( putative N-isopropylammelide isopropylaminohydrolase//N-isopropylammelide isopropylaminohydrolase )</html:p>
<html:p>SUBSYSTEM: atrazine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ISOPROPYLAMMELIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOPROPYLAMINE" stoichiometry="1"/>
      <speciesReference species="CYANURIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SIROHEME__45__FERROCHELAT__45__RXN" name="Sirohydrochlorin ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2429 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative siroheme synthetase )</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8073" name="heme d biosynthesis" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2144_katE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catalase; hydroperoxidase HPII (III), RpoS-dependent//CATAL-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEME_D" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCHORMAT__45__RXN" name="Isochorismatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2833 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Isochorismatase family protein )</html:p>
<html:p>SUBSYSTEM: enterobactin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOCHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRO__45__DIOH__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOHEXOKINASE__45__RXN" name="Ketohexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4075 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Carbohydrate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5120" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3677 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Galactosyl transferase )</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.58</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__930" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__932" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEHYDR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4830_acnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitate hydratase 1//ACONITATEDEHYDR-RXN//ACONITATEHYDR-RXN )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDDEHYDROG__45__RXN" name="Lactaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4549_aldB ) or ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p12RHILE0665_aldH ) or ( p8RHILE0077 ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase B (lactaldehyde dehydrogenase) ) or ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: L-lactaldehyde degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation V</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-D-GLUCOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5114" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3477 ) or ( RHILE1049 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Phosphoserine phosphatase//Phosphoserine phosphatase ) or ( putative Sensory box histidine kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5116" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4494 ) or ( p9RHILE0126 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative SUGAR KINASE PROTEIN (EC 2.7.1.-) ) or ( Ribitol kinase )</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.16</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__RIBULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__RIBULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R223__45__RXN" name="long-chain-fatty-acid-CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0534_fadD ) or ( RHILE1162 ) or ( p10RHILE0412 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)//ACYLCOASYN-RXN ) or ( 2-acylglycerophosphoethanolamine acyltransferase (EC 6.2.1.20) ) or ( putative ACYL-COA SYNTHETASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: octane oxidation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTANOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXKIN__45__RXN" name="Pyridoxal kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Pyridoxal kinase//Pyridoxal kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPPSYN__45__RXN" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4925_ispA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase (=farnesyldiphosphate synthase)//FPPSYN-RXN//GPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: geranyldiphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: geranylgeranyldiphosphate biosynthesis II (plastidic)</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNCARBAMTRANSFER__45__RXN" name="Ornithine carbamoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4385 ) or ( RHILE0583_argF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Ornithine carbamoyltransferase//Ornithine carbamoyltransferase ) or ( ornithine carbamoyltransferase )</html:p>
<html:p>SUBSYSTEM: citrulline degradation</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDRAT__45__RXN" name="Prephenate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0080 ) or ( RHILE0146 ) or ( p12RHILE0771 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative AMINO-ACID-BINDING PERIPLASMIC (PBP) ABC TRANSPORTER PROTEIN ) or ( chorismate mutase/prephenate dehydratase ) or ( putative Prephenate dehydratase//Prephenate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.51</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINSYN__45__RXN" name="argininosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4808 ) or ( RHILE3191 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)//Argininosuccinate synthase ) or ( Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)//Argininosuccinate synthase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2441" name="Trans-aconitate 2-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1397_tam )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-aconitate methyltransferase//RXN0-2441 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.144</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__225" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MONOMETHYL__45__ESTER__45__OF__45__TRANS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0590 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Beta-fructofuranosidase//Beta-fructofuranosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.26</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6081" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: butanediol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0208_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__131__45__RXN" name="Precorrin-3B C17-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0677_cobJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 3 methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.131</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__643" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__651" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMETB12__45__RXN" name="5-methyltetrahydrofolate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3593_metH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase//HOMOCYSMETB12-RXN )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0080 ) or ( p8RHILE0068 ) or ( RHILE2754_iscS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Cysteine desulfurase//Cysteine desulfurase ) or ( putative NifS protein ) or ( cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent//tRNA sulfurtransferase )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ENZYME__45__S__45__SULFANYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0329_glgX ) or ( RHILE4398_glgX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycosyl hydrolase ) or ( glycosyl hydrolase )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__305" name="Hydroxypyruvate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0649_hyi ) or ( RHILE4054 ) or ( RHILE4061_hyi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxypyruvate isomerase ) or ( putative hydroxypyruvate isomerase ) or ( hydroxypyruvate isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__302" name="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2390_ispD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.12</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2713_rpiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose 5-phosphate isomerase B, also acts as allose 6-phosphate isomerase//RIB5PISOM-RXN )</html:p>
<html:p>SUBSYSTEM: D-allose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALLOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALLULOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOVALERYL__45__COA__45__FAD__45__RXN" name="Isovaleryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4806 ) or ( p10RHILE0326_ivd2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acyl-CoA dehydrogenase ) or ( isovaleryl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROURACIL__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Dihydrouracil dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3962_yeiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dihydropyrimidine dehydrogenase, FMN-linked, 4Fe-4S ferredoxin-type protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R342__45__RXN" name="Cobaltochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4635_cobS2 ) or ( RHILE3020_cobN ) or ( RHILE4634_cobT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cobS protein ) or ( putative cobaltochelatase subunit CobN. ) or ( cobT protein )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 6.6.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CO__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__43__2" stoichiometry="1"/>
      <speciesReference species="CPD__45__688" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__689" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__1__46__2__45__RXN" name="Precorrin-8X methylmutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0679_cobH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin isomerase CobH )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 5.4.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__686" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__687" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FADSYN__45__RXN" name="FMN adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0935_ribF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: flavokinase; FAD synthetase//FADSYN-RXN//RIBOFLAVINKIN-RXN//FAD synthetase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.2</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0208_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5141" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1606 ) or ( RHILE0293 ) or ( RHILE2421 ) or ( RHILE0921 ) or ( RHILE3187 ) or ( p11RHILE0579 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Oxidoreductase, aldo/keto reductase family protein ) or ( putative Aryl-alcohol dehydrogenase (NADP+) ) or ( Voltage-gated potassium channel beta-2 subunit (K(+) channel beta-2 subunit) (Kv-beta-2) (HKvbeta2) ) or ( Oxidoreductase (modular protein) ) or ( putative aldoketoreductase ) or ( putative oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.91</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__703" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__702" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxybutyrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0184_bdhA ) or ( RHILE3813 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyrate dehydrogenase ) or ( putative 3-hydroxybutyrate dehydrogenase//3-hydroxybutyrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.30</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__335" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIAZOLSYN3__45__RXN" name="Hydroxyethylthiazole kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0480_thiM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydoxyethylthiazole kinase//THIAZOLSYN3-RXN )</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.50</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THZ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THZ__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R310__45__RXN" name="Nitrile hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3463_nthB ) or ( p11RHILE0130 ) or ( RHILE3464_nthA ) or ( p11RHILE0129_nthA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative nitrile hydratase beta subunit ) or ( putative Low-molecular weight cobalt-containing nitrile hydratase subunit beta (EC 4.2.1.84) (L-nitrilase) (L-NHase) ) or ( nitrile hydratase alpha subunit ) or ( nitrile hydratase alpha subunit )</html:p>
<html:p>SUBSYSTEM: acrylonitrile degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLONITRILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYLGLUCOSAMINE__45__4__45__EPIMERASE__45__RXN" name="UDP-N-acetylglucosamine 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0816 ) or ( p12RHILE0109 ) or ( p12RHILE0234 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPDEPHOS__45__RXN" name="Pyruvate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4337_pyk ) or ( RHILE1043 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Pyruvate kinase//Pyruvate kinase ) or ( putative Pyruvate kinase//Pyruvate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.40</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__C__45__RXN" name="Phospholipase C" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0308 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acid phosphatase )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2773_purB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase//AICARSYN-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBDEHYDROG__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0585_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: transcriptional repressor of proline utilization; proline dehydrogenase; pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8486" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopamine)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8659" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__ACETYLHOMOSERINE__45__THIOL__45__LYASE__45__RXN" name="O-acetylhomoserine (thiol)-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1782 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative O-acetylhomoserine sulfhydrylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.49</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7671" stoichiometry="1"/>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLU6PDEHYDROG__45__RXN" name="Glucose-6-phosphate 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0793_zwf ) or ( p12RHILE0592 ) or ( RHILE1396 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate dehydrogenase//GLU6PDEHYDROG-RXN ) or ( putative glucose-6-phosphate dehydrogenase ) or ( Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) (G6PD)//Glucose-6-phosphate 1-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.49</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8643" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0163_yeaU ) or ( p12RHILE0664_yeaU ) or ( RHILE1045_yeaU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative tartrate dehydrogenase ) or ( putative tartrate dehydrogenase ) or ( putative tartrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.93</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__TARTRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__66" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NANK__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0035 ) or ( RHILE4070 ) or ( p12RHILE0374 ) or ( RHILE3327 ) or ( RHILE4503 ) or ( p11RHILE0544 ) or ( RHILE0516 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glucose kinase ) or ( putative N-acylmannosamine kinase//N-acylmannosamine kinase ) or ( putative ROK family transcriptional regulator ) or ( putative ROK family transcriptional regulator ) or ( putative N-acylmannosamine kinase//N-acylmannosamine kinase ) or ( putative transcriptional regulator protein ) or ( putative TRANSCRIPTION REGULATOR PROTEIN )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine , N-acetylmannosamine and N-acetylneuraminic acid dissimilation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.60</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8642" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2808_idh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__99__46__15__45__RXN" name="(1,4)-&amp;alpha;-D-glucan 1-&amp;alpha;-D-glucosylmutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0012 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycosyl hydrolase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOOLIGOSYLTREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PADENYLTRANS__45__RXN" name="Glucose-1-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4395_glgC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-1-phosphate adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.27</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSDECARB__45__RXN" name="Phosphopantothenoylcysteine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0377_dfp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: 4&apos;-phosphopantothenoylcysteine decarboxylase; phosphopantothenoylcysteine synthetase, FMN-binding//P-PANTOCYSDECARB-RXN//P-PANTOCYSLIG-RXN )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.36</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__HALOACID__45__DEHALOGENASE__45__RXN" name="2-haloacid dehalogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0654 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-haloacid halidohydrolase IVa )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__2__45__Haloacids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__R__45__2__45__Hydroxyacids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Halides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UMPKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2358_pyrH ) or ( RHILE0110_cmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridylate kinase ) or ( cytidine monophosphate (CMP) kinase//CMPKI-RXN )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATEKIN__45__RXN" name="Aspartate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4568_lysC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aspartokinase, alpha and beta subunits//ASPARTATEKIN-RXN )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__81" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0590 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative OXIDOREDUCTASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2743" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTALDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0650_hisD ) or ( p8RHILE0046 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional HisD: L-histidinal:NAD+ dehydrogenase ; L-histidinol:NAD+ dehydrogenase//HISTALDEHYD-RXN//HISTOLDEHYD-RXN ) or ( Histidinol dehydrogenase 2 (EC 1.1.1.23) (HDH 2)//Histidinol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FGAMSYN__45__RXN" name="phosphoribosylformylglycinamidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2786_purQ ) or ( RHILE2781_purL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylformylglycinamide synthetase ) or ( phosphoribosylformylglycinamidine synthase I )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTPPYPHOSKIN__45__RXN" name="GTP diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1597_spoT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: (p)ppGpp synthetase II; guanosine-3&apos;,5&apos;-bis pyrophosphate 3&apos;-pyrophosphohydrolase//GDPPYPHOSKIN-RXN//PPGPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__TP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOGENTISATE__45__12__45__DIOXYGENASE__45__RXN" name="Homogentisate 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1976_hmgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homogentisate 1,2-dioxygenase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.5</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__FORMYLGLUTAMATE__45__DEFORMYLASE__45__RXN" name="N-formylglutamate deformylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4370 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative N-formylglutamate amidohydrolase )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.68</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__600" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0053 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative CYTOCHROME P450 MONOOXYGENASE PROTEIN (EC 1.14.-.-) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_PROPIONYL__45__COA_COF_RXN" name="CO-A_TO_PROPIONYL-COA_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8014" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0537 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative coniferyl aldehyde dehydrogenase (EC 1.2.1.68) (CALDH) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.68</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SINAPALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SINAPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="POLYPHOSPHATE__45__KINASE__45__RXN" name="Polyphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1693_ppk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyphosphate kinase, component of RNA degradosome//POLYPHOSPHATE-KINASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8635" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2123 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative antioxidant protein )</html:p>
<html:p>SUBSYSTEM: betanidin degradation</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.7</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8653" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8890" stoichiometry="1"/>
      <speciesReference species="CPD__45__8653" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0105_goaG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase, PLP-dependent )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8630" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0053 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative CYTOCHROME P450 MONOOXYGENASE PROTEIN (EC 1.14.-.-) )</html:p>
<html:p>SUBSYSTEM: acetone degradation I (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8631" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0800 ) or ( p12RHILE0028 ) or ( RHILE0684 ) or ( p12RHILE0201_cbbA ) or ( RHILE4285 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Fructose-bisphosphate aldolase//Fructose-bisphosphate aldolase ) or ( putative aldolase ) or ( putative Fructose-bisphosphate aldolase//Fructose-bisphosphate aldolase ) or ( fructose-bisphosphate aldolase ) or ( fructose-bisphosphate aldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GABATRANSAM__45__RXN" name="4-aminobutyrate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0105_goaG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase, PLP-dependent )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE__45__OXID__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0665_nadB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative L-aspartate oxidase//L-aspartate oxidase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.-</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMINOASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLSULFAT__45__RXN" name="Arylsulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2028 ) or ( RHILE2402 ) or ( RHILE2405 ) or ( RHILE1309 ) or ( RHILE1213 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sulfatase modifying factor 1 precursor (C-alpha-formyglycine- generating enzyme 1) ) or ( putative Arylsulfatase//Arylsulfatase ) or ( Sulfatase modifying factor 1 precursor (C-alpha-formyglycine- generating enzyme 1) ) or ( putative Arylsulfatase//Arylsulfatase ) or ( putative Arylsulfatase//Arylsulfatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Sulfate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__ATP__45__RXN" name="DNA ligase (ATP)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1374 ) or ( p11RHILE0119 ) or ( p12RHILE0236 ) or ( p12RHILE0218 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative DNA ligase ) or ( putative DNA ligase (ATP)//DNA ligase (ATP) ) or ( ATP-dependent DNA ligase ) or ( putative DNA ligase (ATP)//DNA ligase (ATP) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_SUC_COF_RXN" name="2-KETOGLUTARATE_TO_SUC_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__36__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (GDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0531_otsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate synthase//TREHALOSE6PSYN-RXN )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.36</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__3__46__2__46__9__45__RXN" name="Microsomal epoxide hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1960 ) or ( p12RHILE0313 ) or ( RHILE3109 ) or ( RHILE2925 ) or ( RHILE2612 ) or ( p9RHILE0326 ) or ( RHILE2442 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Epoxide hydrolase ) or ( Epoxide hydrolase (EC 3.3.2.3) ) or ( Epoxide hydrolase (EC 3.3.2.3) ) or ( putative epoxide hydrolase protein ) or ( Epoxide hydrolase (EC 3.3.2.3) ) or ( putative Epoxide hydrolase ) or ( Epoxide hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8984" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8985" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSHTRAN__45__RXN" name="Glutathione transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3338_gst ) or ( RHILE2944 ) or ( RHILE2810 ) or ( RHILE1512 ) or ( RHILE4922 ) or ( RHILE0304 ) or ( p11RHILE0498 ) or ( p10RHILE0369 ) or ( RHILE1282 ) or ( RHILE1416_gst ) or ( RHILE1531 ) or ( RHILE1431 ) or ( RHILE0346 ) or (  ) or ( RHILE3197 ) or ( RHILE1363 ) or ( p11RHILE0332 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathionine S-transferase//GST-RXN ) or ( putative GLUTATHIONE S-TRANSFERASE PROTEIN (EC 2.5.1.18) ) or ( putative Glutathione transferase//Glutathione transferase ) or ( GstA protein ) or ( putative glutathione S-transferase ) or ( putative GLUTATHIONE S-TRANSFERASE PROTEIN (EC 2.5.1.18) ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative Glutathione transferase//Glutathione transferase ) or ( glutathionine S-transferase//GST-RXN ) or ( putative gst14 glutatione S-transferase (EC 2.5.1.18) ) or ( Glutathione S-transferase family protein ) or ( putative glutathione S-transferase ) or ( PUTATIVE GLUTATHIONE S-TRANSFERASE PROTEIN (EC 2.5.1.18) (fragment) ) or ( Glutathione S-transferase ) or ( putative GLUTATHIONE S-TRANSFERASE PROTEIN (EC 2.5.1.18) ) or ( putative glutathione S-transferase P subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RX" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HX" stoichiometry="1"/>
      <speciesReference species="__124__S__45__Substituted__45__Glutathione__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2065_nrd ) or ( RHILE4541_nrdE ) or ( RHILE4540_nrdF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleotide reductase ) or ( ribonucleoside-diphosphate reductase 2, alpha subunit ) or ( ribonucleoside-diphosphate reductase 2, beta subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.4.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxy__45__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5192" name="Lysine 2,3-aminomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4893_yjeK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aminomutase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1032" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTARYL__45__COA__45__DEHYDROGENASE__45__RXN" name="Glutaryl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0423 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOCATECHUATE__45__34__45__DIOXYGENASE__45__RXN" name="Protocatechuate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0090_pcaH ) or ( p11RHILE0089_pcaG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protocatechuate 3,4-dioxygenase beta chain (3,4-PCD) ) or ( protocatechuate 3,4-dioxygenase alpha chain (3,4-PCD) )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.3</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__245" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOLINATE__45__SYNTHE__45__MULTI__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0665_nadB ) or ( p11RHILE0666_nadA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative L-aspartate oxidase//L-aspartate oxidase ) or ( quinolinate synthetase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8447" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__AMINO__45__PROPAN__45__2__45__ONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG1P__45__URIDYLTRANS__45__RXN" name="UDP-N-acetylglucosamine pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2530_glmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal)//NAG1P-URIDYLTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.23</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7567" name="nitrile hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3463_nthB ) or ( p11RHILE0130 ) or ( RHILE3464_nthA ) or ( p11RHILE0129_nthA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative nitrile hydratase beta subunit ) or ( putative Low-molecular weight cobalt-containing nitrile hydratase subunit beta (EC 4.2.1.84) (L-nitrilase) (L-NHase) ) or ( nitrile hydratase alpha subunit ) or ( nitrile hydratase alpha subunit )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLEYL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__237" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__1__46__41__45__RXN" name="5-dehydro-4-deoxyglucarate dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2483_kdgD ) or (  ) or ( p12RHILE0814 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-dehydro-4-deoxyglucarate dehydratase (5-keto-4-deoxy- glucarate dehydratase)//5-dehydro-4-deoxyglucarate dehydratase ) or ( 5-dehydro-4-deoxyglucarate dehydratase (5-keto-4-deoxy- glucarate dehydratase) (fragment)//5-dehydro-4-deoxyglucarate dehydratase ) or ( putative 5-dehydro-4-deoxyglucarate dehydratase//5-dehydro-4-deoxyglucarate dehydratase ) or ( 5-dehydro-4-deoxyglucarate dehydratase (5-keto-4-deoxy- glucarate dehydratase) (fragment)//5-dehydro-4-deoxyglucarate dehydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.41</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__KETO__45__4__45__DEOXY__45__D__45__GLUCARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__654" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALSYN__45__RXN" name="malate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0054_glcB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate synthase G//MALSYN-RXN )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.9</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0053 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative CYTOCHROME P450 MONOOXYGENASE PROTEIN (EC 1.14.-.-) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2750" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINE__45__KINASE__45__RXN" name="Ethanolamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0159 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Ethanolamine kinase//Ethanolamine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.82</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYL__45__ALCOHOL__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0536_areB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__Aldehyde__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0053 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative CYTOCHROME P450 MONOOXYGENASE PROTEIN (EC 1.14.-.-) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2751" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PORPHOBILSYNTH__45__RXN" name="Porphobilinogen synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1711_hemB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-aminolevulinate dehydratase (porphobilinogen synthase)//PORPHOBILSYNTH-RXN )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.24</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8036" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0363 ) or ( RHILE4450 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Beta-glucosidase (EC 3.2.1.21) (Gentiobiase) (Cellobiase) (Beta-D- glucoside glucohydrolase)//Beta-glucosidase ) or ( Beta-glucosidase (EC 3.2.1.21) (Gentiobiase) (Cellobiase) (Beta-D- glucoside glucohydrolase) (Amygdalase)//Beta-glucosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7417" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7418" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ERYTH4PDEHYDROG__45__RXN" name="Erythrose-4-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4280_epd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-erythrose 4-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.72</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHRONATE__45__4P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__169" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0053 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative CYTOCHROME P450 MONOOXYGENASE PROTEIN (EC 1.14.-.-) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3188" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5184" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4393_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R344__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3019_btuR ) or ( RHILE4601 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)alamin and cobinamide ATP-dependent adenolsyltransferase//BTUR2-RXN//COBALADENOSYLTRANS-RXN ) or ( DUF80 )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__694" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3785 ) or ( RHILE0788 ) or ( p12RHILE0747 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alpha-glucosidase (EC 3.2.1.20) ) or ( putative alpha-glucosidase (EC 3.2.1.20) ) or ( putative ALPHA-AMYLASE-RELATED PROTEIN )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5180" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2360_ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)//RXN0-5180 )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PQQ_TO_CPD__45__104_COF_RXN" name="PQQ_TO_CPD-104_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PQQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__104" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATEORTHOPHOSPHATE__45__DIKINASE__45__RXN" name="Pyruvate,phosphate dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1137 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate phosphate dikinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4393_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5181" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0747 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ALPHA-AMYLASE-RELATED PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOHEXAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R311__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2201_GatA2 ) or ( p9RHILE0215 ) or ( p11RHILE0464 ) or ( RHILE0232 ) or ( p12RHILE0140 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( putative amidase ) or ( Glutamyl-tRNA amidotransferase subunit A ) or ( putative amidase ) or ( putative AMIDASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: acrylonitrile degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEHYDDEOXPHOSGALACT__45__ALDOL__45__RXN" name="2-dehydro-3-deoxyphosphogalactonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4124 ) or ( RHILE0966_dgoA ) or ( RHILE4130 ) or ( RHILE4132 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-dehydro-3-deoxy-6-phosphogalactonate aldolase//2-dehydro-3-deoxy-6-phosphogalactonate aldolase ) or ( bifunctional: 2-dehydro-3-deoxygalactonate 6-phosphate aldolase (N-terminal); galactonate dehydratase (C-terminal)//DEHYDDEOXPHOSGALACT-ALDOL-RXN ) or ( putative 2-dehydro-3-deoxy-6-phosphogalactonate aldolase//2-dehydro-3-deoxy-6-phosphogalactonate aldolase ) or ( putative 2-dehydro-3-deoxy-6-phosphogalactonate aldolase//2-dehydro-3-deoxy-6-phosphogalactonate aldolase )</html:p>
<html:p>SUBSYSTEM: D-galactonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDRO__45__DEOXY__45__GALACTONATE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__61" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0053 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative CYTOCHROME P450 MONOOXYGENASE PROTEIN (EC 1.14.-.-) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOSE__45__6__45__PHOSPHATE__45__PHOSPHOKETOLASE__45__RXN" name="Fructose-6-phosphate phosphoketolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4171 ) or ( RHILE0068 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase ) or ( D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBREDUCT__45__RXN" name="Pyrroline-5-carboxylate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3698_proC ) or ( p12RHILE0445 ) or ( p12RHILE0548 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrroline-5-carboxylate reductase ) or ( putative Pyrroline-5-carboxylate reductase//Pyrroline-5-carboxylate reductase ) or ( putative Pyrroline-5-carboxylate reductase (EC 1.5.1.2) (P5CR) (P5C reductase)//Pyrroline-5-carboxylate reductase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Reduced__45__Factor__45__F420__124___TO___124__Factor__45__420__124___COF_RXN" name="|Reduced-Factor-F420|_TO_|Factor-420|_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Reduced__45__Factor__45__F420__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Factor__45__420__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPCARBTRANS__45__RXN" name="Aspartate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1846_pyrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate carbamoyltransferase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.2</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p8RHILE0077 ) or ( p12RHILE0665_aldH ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2144_katE ) or ( p12RHILE0382_katG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catalase; hydroperoxidase HPII (III), RpoS-dependent//CATAL-RXN ) or ( catalase; hydroperoxidase HPI(I)//CATAL-RXN )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8442" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0208_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="D__45__RIBULOSE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8259" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R468__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0387 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cyanuric acid amidohydrolase (EC 3.5.2.15)//Cyanuric acid amidohydrolase )</html:p>
<html:p>SUBSYSTEM: cyanurate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.15</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYANURIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__809" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8441" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4150 ) or ( RHILE3014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative inosine-uridine preferring nucleoside hydrolase protein ) or ( putative Purine nucleosidase//Purine nucleosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRCARBOXY__45__RXN" name="Phosphoribosylaminoimidazole carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4320_purE ) or ( RHILE4321_purK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit ) or ( phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.21</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DALADALALIG__45__RXN" name="D-alanine--D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3531_ddlB ) or ( RHILE2990_ddlA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-alanine-D-alanine ligase B, affects cell division//DALADALALIG-RXN ) or ( D-alanine-D-alanine ligase A//DALADALALIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FHLMULTI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0319_hycD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydrogenase 3, membrane subunit (part of FHL complex) )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8813" name="Trans-pentaprenyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0988_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIENOYLCOAREDUCT__45__RXN" name="2,4-dienoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0536 ) or ( p12RHILE0550 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2,4-dienoyl-CoA reductase (NADPH)//2,4-dienoyl-CoA reductase (NADPH) ) or ( putative N-methylproline demethylase (EC 1.-.-.-) (Stachydrine utilization protein stcD) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="T2__45__DECENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="T2__45__C4__45__DECADIENYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R322__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0681 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-6A synthase [deacetylating] (EC 2.1.1.152) )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.152</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__662" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__675" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINO__45__CARBOXYMUCONATE__45__SEMIALDEHYDE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2499 ) or ( p12RHILE0223 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Aminocarboxymuconate-semialdehyde decarboxylase//Aminocarboxymuconate-semialdehyde decarboxylase ) or ( Thermophilic reversible gamma-resorcylate decarboxylase )</html:p>
<html:p>SUBSYSTEM: 2-amino-3-carboxymuconate semialdehyde degradation to 2-oxopentenoate</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.45</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXII__45__RXN" name="Hydroxyacylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4624 ) or ( RHILE1197 ) or ( RHILE3264 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glyoxalase II ) or ( putative Hydroxyacylglutathione hydrolase//Hydroxyacylglutathione hydrolase ) or ( putative Hydroxyacylglutathione hydrolase//Hydroxyacylglutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOGLYCOSIDE__45__N3__45__ACETYLTRANSFERASE__45__RXN" name="Aminoglycoside N3&apos;-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1250 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aminoglycoside N(3&apos;)-acetyltransferase III (EC 2.3.1.81) (ACC(3)-III) (Aminocyclitol 3-N-acetyltransferase type III) (Gentamicin-(3)-N- acetyl-transferase)//Aminoglycoside N(3&apos;)-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.81</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxystreptamine__45__Antib__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__N3__45__Acetal__45__deoxystreptamine__45__antib__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PPENTOMUT__45__RXN" name="Phosphopentomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0214_deoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphopentomutase//D-PPENTOMUT-RXN//PPENTOMUT-RXN )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DXS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1023_dxs ) or ( RHILE2902 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose 5-phosphate synthase; flavoprotein, thiamin-binding//DXS-RXN ) or ( putative 1-deoxy-D-xylulose-5-phosphate synthase//1-deoxy-D-xylulose-5-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.7</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALDEHYDROG__45__RXN" name="3-isopropylmalate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5003_leuB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.85</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0053 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative CYTOCHROME P450 MONOOXYGENASE PROTEIN (EC 1.14.-.-) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3481" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3483" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZALDEHYDE__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Benzaldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0517_hcaB ) or ( p12RHILE0524_hcaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxybenzaldehyde dehydrogenase ) or ( hydroxybenzaldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: mandelate degradation I</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoate</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.28</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXY__45__MANDELATE__45__RACEMASE__45__RXN" name="Mandelate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0245 ) or ( p11RHILE0641 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative mandelate racemase ) or ( Mandelate racemase/muconate lactonizing enzyme domain protein//Mandelate racemase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__105" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__106" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEYLACETOACETATE__45__ISOMERASE__45__RXN" name="Maleylacetoacetate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2920 ) or ( RHILE4922 ) or ( RHILE1978_maiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Maleylacetoacetate isomerase (EC 5.2.1.2) (MAAI)//Maleylacetoacetate isomerase ) or ( putative glutathione S-transferase ) or ( putative maleylacetoacetate isomerase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8277" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3901 ) or ( RHILE3677 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative galactosyl transferase PssJ ) or ( Galactosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
      <speciesReference species="CPD__45__8046" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8047" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METBALT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0587_metZ ) or ( p12RHILE0394 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-succinylhomoserine sulfhydrylase ) or ( putative Cystathionine gamma-synthase//Cystathionine gamma-synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.48</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__76__45__RXN" name="Arylmalonate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0053 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Arylmalonate decarboxylase//Arylmalonate decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.76</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ARYL__45__2__45__METHYLMALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ARYLPROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0328 ) or ( p12RHILE0464 ) or ( p9RHILE0032_adhP ) or ( RHILE1990 ) or ( p10RHILE0115 ) or ( p10RHILE0129 ) or ( RHILE1407 ) or ( p9RHILE0106 ) or ( p10RHILE0148 ) or ( p12RHILE0555_adhC ) or (  ) or ( p12RHILE0636 ) or ( RHILE3574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alcohol dehydrogenase, propanol-preferring ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase, propanol-preferring//ALCOHOL-DEHYDROG-GENERIC-RXN//ALCOHOL-DEHYDROG-RXN ) or ( putative Zn-containing alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase ) or ( putative OXIDOREDUCTASE TRANSMEMBRANE PROTEIN ) or ( Alcohol dehydrogenase (EC 1.1.1.1)//Alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase class III ) or ( putative iron-containing alcohol dehydrogenase (fragment) ) or ( Alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis II (Gram-positive bacteria)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1K__45__87" name="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0016 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__787" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1401" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGENSYN__45__RXN" name="Starch (bacterial glycogen) synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( RHILE4396_glgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative glycosyl transferase PssS (fragment) ) or ( glycogen synthase//GLYCOGENSYN-RXN )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.21</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__57__45__RXN" name="Phosphatidyl-myo-inositol &amp;alpha;-mannosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0694 ) or ( RHILE4885 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Phosphatidylinositol alpha-mannosyltransferase//Phosphatidylinositol alpha-mannosyltransferase ) or ( Cellobiosyl-diphosphoprenyl alpha-mannosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.57</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__MYO__45__INOSITOL__45__2__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5199" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0208_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA__45__DECARBOXYLASE__45__RXN" name="Malonyl-CoA decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1040_MLYCD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malonyl-CoA decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP cyclohydrolase I" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2696_gch1 ) or ( RHILE3756 ) or ( p12RHILE0603_gch1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative GTP cyclohydrolase I//GTP cyclohydrolase I ) or ( GTP cyclohydrolase I ) or ( putative GTP cyclohydrolase I//GTP cyclohydrolase I )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.16</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__60__45__RXN" name="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2390_ispD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.60</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__170" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0053 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative CYTOCHROME P450 MONOOXYGENASE PROTEIN (EC 1.14.-.-) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3188" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2749" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMSUCTRAN__45__RXN" name="Homoserine O-succinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4901_metA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoserine transsuccinylase//HOMSUCTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.46</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_CPD__45__558_COF_RXN" name="CO-A_TO_CPD-558_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__558" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHA__45__AMYL__45__RXN" name="&amp;alpha;-amylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0747 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ALPHA-AMYLASE-RELATED PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOPENTAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPCARBOXYKIN__45__RXN" name="Phosphoenolpyruvate carboxykinase (ATP)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0037_pck )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoenolpyruvate carboxykinase//PEPCARBOXYKIN-RXN )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.49</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOASYN__45__RXN" name="long-chain-fatty-acid--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0534_fadD ) or ( RHILE1162 ) or ( p10RHILE0412 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)//ACYLCOASYN-RXN ) or ( 2-acylglycerophosphoethanolamine acyltransferase (EC 6.2.1.20) ) or ( putative ACYL-COA SYNTHETASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUTP__45__PYROP__45__RXN" name="dUTP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0365_dut )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyuridinetriphosphatase//DUTP-PYROP-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOLACT__45__RXN" name="Gluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0304 ) or ( RHILE4522 ) or ( p10RHILE0422 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative gluconolactonase (EC 3.1.1.17) (modular protein) ) or ( putative gluconolactonase protein (EC 3.1.1.17) ) or ( putative Gluconolactonase//Gluconolactonase )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLMETHIONINE__45__DEFORMYLASE__45__RXN" name="Formylmethionine deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0453_def )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptide deformylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__FORMYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMARYLACETOACETASE__45__RXN" name="Fumarylacetoacetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3392 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Fumarylacetoacetate (FAA) hydrolase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINASE__45__RXN" name="Adenosylhomocysteinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0907 ) or ( RHILE0031_ahcY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Adenosylhomocysteinase (EC 3.3.1.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase)//Adenosylhomocysteinase ) or ( S-adenosyl L-homocysteine hydrolase )</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>PROTEIN_CLASS: 3.3.1.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIENELACHYDRO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0524 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dienelactone hydrolase family protein )</html:p>
<html:p>SUBSYSTEM: 1,4-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__CHLORO__45__TRANS__45__DIENELACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__CHLOROMALEYLACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2661" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1129_mutY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenine DNA glycosylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__With__45__G__45__A__45__Mismatch__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__DNA__45__With__45__Mismatched__45__Adenine__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__8__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4787_gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase (NAD+)//GLYC3PDEHYDROGBIOSYN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__METHOXY__45__BENZOQ__45__METH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0392_ubiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase; S-adenosylmethionine:2-DMK methyltransferase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHOXY__45__BENZOQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__821" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0585_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: transcriptional repressor of proline utilization; proline dehydrogenase; pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_24__45__DICHLOROPHENOL__45__6__45__MONOOXYGENASE__45__RXN" name="2,4-dichlorophenol 6-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0097 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dichlorophenol 6-monooxygenase (EC 1.14.13.20) (2,4-dichlorophenol hydroxylase) (2,4-DCP hydroxylase)//2,4-dichlorophenol 6-monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.20</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_24__45__DICHLOROPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_35__45__DICHLOROCATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3764 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Formate--tetrahydrofolate ligase (EC 6.3.4.3) (Formyltetrahydrofolate synthetase) (FHS) (FTHFS)//Formate--tetrahydrofolate ligase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SELENOCYSTEINE__45__LYASE__45__RXN" name="Selenocysteine lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2749_csdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( selenocysteine lyase, PLP-dependent )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__SELENOCYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__678" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0783_folD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5727" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOKIN__45__RXN" name="Glucokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1757 ) or ( p12RHILE0730 ) or ( p12RHILE0035 ) or ( RHILE2472 ) or ( RHILE0679 ) or ( RHILE0188 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ROK-family transcriptional regulator ) or ( putative Glucokinase//Glucokinase ) or ( Glucose kinase ) or ( Transcriptional regulator, ROK family ) or ( putative TRANSCRIPTION REGULATOR PROTEIN ) or ( Glucokinase (EC 2.7.1.2) (Glucose kinase)//Glucokinase )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="ribose-phosphate diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3706_prs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylpyrophosphate synthetase )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8292" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3901 ) or ( RHILE3677 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative galactosyl transferase PssJ ) or ( Galactosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__O__45__METHYL__45__MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8071" stoichiometry="1"/>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHA__45__L__45__FUCOSIDASE__45__RXN" name="&amp;alpha;-L-fucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0301 ) or ( p12RHILE0716 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycosyl hydrolase ) or ( putative glycosyl hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.51</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AN__45__ALPHA__45__L__45__FUCOSIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="L__45__FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENINE__45__DEAMINASE__45__RXN" name="adenine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4151 ) or ( RHILE2134 ) or ( RHILE4765 ) or ( RHILE3783_ade ) or ( p9RHILE0178 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenine deaminase 2 (EC 3.5.4.2) (Adenase 2) (Adenine aminase 2)//Adenine deaminase ) or ( Adenine deaminase 2 (EC 3.5.4.2) (Adenase 2) (Adenine aminase 2)//Adenine deaminase ) or ( Adenine deaminase 1 (EC 3.5.4.2) (Adenase 1) (Adenine aminase 1)//Adenine deaminase ) or ( adenine deaminase ) or ( Adenine deaminase 1 (EC 3.5.4.2) (Adenase 1) (Adenine aminase 1)//Adenine deaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEYLACETATE__45__REDUCTASE__45__RXN" name="Maleylacetate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0103 ) or ( p12RHILE0221 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Maleylacetate reductase (EC 1.3.1.32)//Maleylacetate reductase ) or ( Maleylacetate reductase (EC 1.3.1.32)//Maleylacetate reductase )</html:p>
<html:p>SUBSYSTEM: 1,4-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.32</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETO__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__382" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4459_xylB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylulokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1093" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8001" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0650_hisD ) or ( p8RHILE0046 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional HisD: L-histidinal:NAD+ dehydrogenase ; L-histidinol:NAD+ dehydrogenase//HISTALDEHYD-RXN//HISTOLDEHYD-RXN ) or ( Histidinol dehydrogenase 2 (EC 1.1.1.23) (HDH 2)//Histidinol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETAGALACTOSID__45__RXN" name="&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3322 ) or ( p9RHILE0136 ) or ( RHILE4063 ) or ( RHILE4530 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Beta-D-galactosidase ) or ( putative Beta-galactosidase//Beta-galactosidase ) or ( putative Beta-galactosidase//Beta-galactosidase ) or ( Beta-galactosidase (EC 3.2.1.23) (Lactase)//Beta-galactosidase )</html:p>
<html:p>SUBSYSTEM: lactose degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAMKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Pyridoxal kinase//Pyridoxal kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLORIDE__45__PEROXIDASE__45__RXN" name="Chloride peroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3169 ) or ( p11RHILE0143 ) or ( p11RHILE0092 ) or ( p12RHILE0476 ) or ( RHILE2344 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( non-heme chloroperoxidase ) or ( non-heme chloroperoxidase ) or ( putative beta-ketoadipate enol-lactone hydrolase protein (EC 3.1.1.24) ) or ( non-heme chloroperoxidase ) or ( putative hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.10</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CL__45__" stoichiometry="2"/>
      <speciesReference species="RH" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Chlorides__124__" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4271_gnd ) or ( RHILE2996_gnd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase//6PGLUCONDEHYDROG-RXN ) or ( gluconate-6-phosphate dehydrogenase, decarboxylating//6PGLUCONDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__986" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0039_alkB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions, repair of alkylated DNA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__ETHYLADENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Formaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0405 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutathione-independent formaldehyde dehydrogenase (EC 1.2.1.46) (FDH) (FALDH) )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation IV (thiol-independent)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.46</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__984" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0039_alkB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions, repair of alkylated DNA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N1__45__METHYLADENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSINE__45__NUCLEOSIDASE__45__RXN" name="Adenosine nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4150 ) or ( RHILE3014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative inosine-uridine preferring nucleoside hydrolase protein ) or ( putative Purine nucleosidase//Purine nucleosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__985" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0039_alkB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions, repair of alkylated DNA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N3__45__METHYLCYTOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOACYLCOATHIOL__45__RXN" name="Acetyl-CoA C-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0627 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acyl-CoA thiolase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.16</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__KINASE__45__RXN" name="shikimate-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4640_aroK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( shikimate kinase I//SHIKIMATE-KINASE-RXN )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.71</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8281" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3901 ) or ( RHILE3677 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative galactosyl transferase PssJ ) or ( Galactosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__METHYL__45__MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8058" stoichiometry="1"/>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOKIN__45__RXN" name="Ribokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2932_rbsK ) or ( RHILE2815 ) or ( p12RHILE0009 ) or ( RHILE0450 ) or ( p9RHILE0229_rbsK ) or ( p12RHILE0029 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribokinase ) or ( putative Ribokinase//Ribokinase ) or ( putative Ribokinase//Ribokinase ) or ( RBSK ) or ( ribokinase ) or ( putative Ribokinase//Ribokinase )</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.15</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3541" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2589 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative copper-containing oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__318" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ESTRADIOL__45__17__45__BETA__45__DEHYDROGENASE__45__RXN" name="Estradiol 17 &amp;beta;-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4809 ) or ( RHILE4039 ) or ( p11RHILE0548 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Short-chain dehydrogenase/reductase SDR:Glucose/ribitol dehydrogenase ) or ( putative short chain oxidoreductase protein ) or ( putative oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.62</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__352" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ESTRONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__PQQ__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4095_quiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinate/shikimate dehydrogenase [Pyrroloquinoline-quinone] (NAD(P)-independent quinate dehydrogenase) )</html:p>
<html:p>SUBSYSTEM: shikimate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.25</html:p>
<html:p>COFACTOR: PQQ</html:p>
<html:p>COFACTOR: CPD__45__104</html:p>
<html:p>SIDE: PQQ</html:p>
<html:p>SIDE: CPD__45__104</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__7__45__RXN" name="Kynurenine--oxoglutarate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0064_aspC ) or ( RHILE4764_aspC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate aminotransferase, PLP-dependent//ASPAMINOTRANS-RXN ) or ( aspartate aminotransferase, PLP-dependent//ASPAMINOTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.7</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__476" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACECOATRANS__45__RXN" name="Acetate CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0310_atoD ) or ( RHILE1932 ) or ( p12RHILE0783_ydiF ) or ( p11RHILE0311_atoA ) or ( p10RHILE0131_ydiF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit ) or ( putative Acetyl-CoA-transferase subunit ) or ( putative bifunctional acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit (N-terminal); beta subunit (C-terminal) ) or ( acetyl-CoA:acetoacetyl-CoA transferase, beta subunit ) or ( putative bifunctional acetyl-CoA:acetoacetyl-CoA transferase: alpha subunit (N-terminal); beta subunit (C-terminal) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2903 ) or ( RHILE4279_tktA ) or ( p10RHILE0490_tktB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative transketolase N-terminal section (EC 2.2.1.1) (TK) ) or ( transketolase 1 thiamin-binding, isozyme//1TRANSKETO-RXN//2TRANSKETO-RXN ) or ( transketolase 2, thiamin-binding, isozyme//1TRANSKETO-RXN//2TRANSKETO-RXN )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__KIN__45__RXN" name="NAD(+) kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1862 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative inorganic polyphosphate/ATP-NAD kinase (EC 2.7.1.23) (Poly(P)/ATP NAD kinase) )</html:p>
<html:p>SUBSYSTEM: NAD phosphorylation and dephosphorylation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.23</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__IDITOL__45__2__45__DEHYDROGENASE__45__RXN" name="L-iditol 2-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0544 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ZINC-TYPE ALCOHOL DEHYDROGENASE PROTEIN (EC 1.1.1.-) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__369" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Quinones__124___TO___124__Reduced__45__Quinones__124___COF_RXN" name="|Quinones|_TO_|Reduced-Quinones|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Reduced__45__Quinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__TYROSINE__45__PHOSPHATASE__45__RXN" name="Protein-tyrosine-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4821 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphotyrosine protein phosphatase (PtpA) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.48</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALGLDAPAALIG__45__RXN" name="UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3541_murF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-alanine:D-alanine-adding enzyme//Deleted entry )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C1" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATE__45__1__45__EPIMERASE__45__RXN" name="Glucose-6 phosphate 1-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINESYN__45__RXN" name="Spermidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Spermidine synthase//Spermidine synthase )</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__361" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0404_rihA ) or ( p12RHILE0180_rihA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleoside hydrolase 1, pyrimidine-specific ) or ( ribonucleoside hydrolase 1, pyrimidine-specific )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__363" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4150 ) or ( RHILE3014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative inosine-uridine preferring nucleoside hydrolase protein ) or ( putative Purine nucleosidase//Purine nucleosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TARTRATE__45__DEHYDROGENASE__45__RXN" name="Tartrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0163_yeaU ) or ( p12RHILE0664_yeaU ) or ( RHILE1045_yeaU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative tartrate dehydrogenase ) or ( putative tartrate dehydrogenase ) or ( putative tartrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.93</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__66" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMAMIDASE__45__RXN" name="Formamidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0385 ) or ( p11RHILE0484 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Formamidase (EC 3.5.1.49) (Formamide amidohydrolase)//Formamidase ) or ( putative Formamidase//Formamidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.49</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__366" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4150 ) or ( RHILE3014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative inosine-uridine preferring nucleoside hydrolase protein ) or ( putative Purine nucleosidase//Purine nucleosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSAAMINOTRANS__45__RXN" name="Glutamate-1-semialdehyde 2,1-aminomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4770 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glutamate-1-semialdehyde aminotransferase (aminomutase), PLP-dependent )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTAMATE__45__1__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2043" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1748 ) or ( RHILE0244 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative endoglucanase ) or ( Endoglucanase precursor )</html:p>
<html:p>SUBSYSTEM: cellulose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__40__1__45__4__45____38__amp__59__amp__59__beta__59____45__D__45__glucan__41____40__m__43__n__41__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__40__1__45__4__45____38__amp__59__amp__59__beta__59____45__D__45__glucan__41____40__n__41__" stoichiometry="1"/>
      <speciesReference species="__40__1__45__4__45____38__amp__59__amp__59__beta__59____45__D__45__glucan__41____40__m__41__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERKIN__45__RXN" name="Homoserine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0240 ) or ( p8RHILE0075 ) or ( RHILE1081_thrB ) or ( RHILE1256 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aminotransferase, class III ) or ( putative Homoserine kinase (EC 2.7.1.39) (HSK) (HK)//Homoserine kinase ) or ( homoserine kinase ) or ( putative Homoserine kinase//Homoserine kinase )</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.39</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3428_ilvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ketol-acid reductoisomerase )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLULOSE__45__REDUCTASE__45__RXN" name="D-xylulose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0419 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative D-xylulose reductase (EC 1.1.1.9) (Xylitol dehydrogenase) (XDH)//D-xylulose reductase )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDHMSARC__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0318 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbon-monoxide dehydrogenase small subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__3__45__PHOSPHATE__45__OXIDASE__45__RXN" name="Glycerol-3-phosphate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0202 ) or ( p12RHILE0799 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycerol-3-phosphate dehydrogenase (EC 1.1.99.5) ) or ( putative glycerol-3-phosphate dehydrogenase protein (EC 1.1.99.5) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICONUCADENYLYLTRAN__45__RXN" name="Nicotinate-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4979 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative nicotinate-nucleotide adneylyltransferase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__133__45__RXN" name="Precorrin-4 C11-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0674_cobM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 3 or 4 methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.133</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__CARBOXY__45__2__45__OXO__45__3__45__HEXENEDIOATE__45__RXN" name="2-oxopent-4-enoate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0289_ligJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-oxalomesaconate hydratase )</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.80</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__OH__45__4__45__ACETYL__45__2__45__OXOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OCTAPRENYL__45__4__45__OHBENZOATE__45__DECARBOX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4754_ubiX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-octaprenyl-4-hydroxybenzoate carboxy-lyase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYLPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1241" name="coniferyl-aldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0537 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative coniferyl aldehyde dehydrogenase (EC 1.2.1.68) (CALDH) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.68</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CONIFERYL__45__ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYRIBONUCSYN__45__RXN" name="Phosphoribosylamine--glycine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0998_purD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide synthetase (GAR synthetase)//GLYRIBONUCSYN-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATE__45__REDUCTASE__45__NADPH__45__RXN" name="Nitrate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3222 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Nitrate reductase (NADPH)//Nitrate reductase (NADPH) )</html:p>
<html:p>SUBSYSTEM: nitrate reduction V (assimilatory)</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3561" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0026_caiD ) or ( p10RHILE0413_caiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitinyl-CoA dehydratase (Crotonobetainyl-CoA hydratase) ) or ( crotonobetainyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: carnitine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CARNITINYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONOBETAINYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFATE__45__ADENYLYLTRANS__45__RXN" name="Sulfate adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1339_cysN ) or ( RHILE1340_cysD ) or ( RHILE3436 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP-sulfurylase, subunit 1 (ATP:sulfate adenylyltransferase)//SULFATE-ADENYLYLTRANS-RXN ) or ( ATP-sulfurylase, subunit 2 (ATP:sulfate adenylyltransferase)//SULFATE-ADENYLYLTRANS-RXN ) or ( Oxytetracycline resistance protein )</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: sulfite oxidation III</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.4</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PPGPPSYN__45__RXN" name="Guanosine-3&apos;,5&apos;-bis(diphosphate) 3&apos;-pyrophosphohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1597_spoT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: (p)ppGpp synthetase II; guanosine-3&apos;,5&apos;-bis pyrophosphate 3&apos;-pyrophosphohydrolase//GDPPYPHOSKIN-RXN//PPGPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.7.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE__45__5DP__45__3DP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OXALODECARB__45__RXN" name="Oxaloacetate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4444_eda )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase//KDPGALDOL-RXN//OXALODECARB-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__5__46__1__46__2__45__RXN" name="3-carboxy-cis,cis-muconate cycloisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0088 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-carboxy-cis,cis-muconate cycloisomerase protein (EC 5.5.1.2)//3-carboxy-cis,cis-muconate cycloisomerase )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__245" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7737" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRIBFAICARPISOM__45__RXN" name="N-(5&apos;-phospho-D-ribosylformimino)-5-amino-1-(5&apos;&apos;-phosphoribosyl)-4- imidazole carboxamide isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0864 ) or ( RHILE0043_hisA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative imidazole glycerol phosphate synthase subunit hisF2 (EC 4.1.3.-) (IGP synthase cyclase subunit) (IGP synthase subunit hisF2) (ImGP synthase subunit hisF2) (IGPS subunit hisF2) ) or ( N-(5&apos;-phospho-L-ribosyl-formimino)-5-amino-1-(5&apos;-phosphoribosyl)-4-imidazolecarboxamide isomerase//PRIBFAICARPISOM-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALTRODEHYDRAT__45__RXN" name="Altronate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0550 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative D-galactarate dehydratase (EC 4.2.1.42) (GalcD) )</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: D-galacturonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.7</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALTRONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1679_pgsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylglycerophosphate synthetase (CDP-1,2-diacyl-sn-glycero-3-phosphate phosphatidyl transferase)//PHOSPHAGLYPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.5</html:p>
<html:p>SIDE: GLYCEROL__45__3P</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLPROLYL__45__ISOMERASE__45__RXN" name="Peptidylprolyl isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2555 ) or ( RHILE2556 ) or ( RHILE4581 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Peptidylprolyl isomerase//Peptidylprolyl isomerase ) or ( peptidyl prolyl cis-trans isomerase ) or ( putative Peptidylprolyl isomerase//Peptidylprolyl isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8625" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__NITROPROPANE__45__DIOXYGENASE__45__RXN" name="2-nitropropane dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2439 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-nitropropane dioxygenase )</html:p>
<html:p>SUBSYSTEM: 2-nitropropane degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.32</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ACETONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__244" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="2"/>
      <speciesReference species="ACETONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDGALDOL__45__RXN" name="2-dehydro-3-deoxyglucarate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0469 ) or (  ) or ( p11RHILE0166 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase ) or ( putative 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, with PEP/pyruvate domain (fragment) ) or ( putative aldolase )</html:p>
<html:p>SUBSYSTEM: D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.20</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__KETO__45__4__45__DEOXY__45__D__45__GLUCARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENOL__45__2__45__MONOOXYGENASE__45__RXN" name="Phenol 2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative FERREDOXIN OXIDOREDUCTASE PROTEIN (fragment) )</html:p>
<html:p>SUBSYSTEM: phenol degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__81__45__RXN" name="Threonine-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3011_cobC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cobalamin biosynthetic protein CobC )</html:p>
<html:p>SUBSYSTEM: aminopropanol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.81</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__THREONINE__45__O__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__1__45__AMINOPROPAN__45__2__45__YL__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__17__45__RXN" name="Phosphatidylethanolamine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1421 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphatidylethanolamine N-methyltransferase (EC 2.1.1.17)//Phosphatidylethanolamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.17</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__405" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__130__45__RXN" name="Precorrin-2 C20-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0678_cobI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 2 methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.130</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__642" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__2__46__3__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0629 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__3__45__HYDROXYBUTANOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0555_adhC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase class III )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.284</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOSEPHOSPHO__45__RXN" name="transport of fructose by PTS" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0448 ) or ( p11RHILE0412 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative NITROGEN REGULATORY IIA PROTEIN (EC 2.7.1.69) ) or ( Phosphotransferase enzyme IIA (EC 2.7.1.69) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU1P" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1401" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0169_phnN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose 1,5-bisphosphokinase )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__15__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GART__45__RXN" name="Phosphoribosylglycinamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1688_purN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase 1//GART-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.2</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HALOALKANE__45__DEHALOGENASE__45__RXN" name="Haloalkane dehalogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0576 ) or ( p11RHILE0072 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Haloalkane dehalogenase (EC 3.8.1.5)//Haloalkane dehalogenase ) or ( putative Haloalkane dehalogenase//Haloalkane dehalogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__Haloalkanes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Primary__45__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Halides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1223" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4247 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-sulfoquinovose synthase, chloroplast precursor (EC 3.13.1.1) (Sulfite:UDP-glucose sulfotransferase) (Sulfolipid biosynthesis protein) (SoSQD1)//UDP-sulfoquinovose synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.13.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__SULFOQUINOVOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__8__45__RXN" name="Dimethylaniline monooxygenase (N-oxide forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0590 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative OXIDOREDUCTASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NN__45__DIMETHYLANILINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NN__45__DIMETHYLANILINE__45__N__45__OXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD_TO_FADH2_COF_RXN" name="FAD_TO_FADH2_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FADH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4321_purK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.18</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__181" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.22</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__743" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4320_purE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__181" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNONDEHYDRAT__45__RXN" name="Mannonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2484 ) or ( p9RHILE0065_uxuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Mannonate dehydratase//Mannonate dehydratase ) or ( mannonate hydrolase//MANNONDEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__MANNONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREODEHYD__45__RXN" name="L-threonine 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3640_tdh ) or ( RHILE0689 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine 3-dehydrogenase, NAD(P)-binding//THREODEHYD-RXN ) or ( putative ZINC-CONTAINING ALCOHOL DEHYDROGENASE PROTEIN (EC 1.1.1.-) )</html:p>
<html:p>SUBSYSTEM: threonine degradation II</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>SUBSYSTEM: aminopropanol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.103</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__274__45__RXN" name="2,5-didehydrogluconate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0123 ) or ( p12RHILE0111 ) or ( RHILE4852_dkgA ) or ( RHILE1798 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxidoreductase ) or ( putative oxidoreductase (EC 1.1.1.21) ) or ( 2,5-diketo-D-gluconate reductase A//1.1.1.274-RXN//RXN0-1941 ) or ( putative OXIDOREDUCTASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.274</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_25__45__DIDEHYDRO__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHEAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0064_aspC ) or ( RHILE4764_aspC ) or ( RHILE4622_hisC ) or ( RHILE4926_hisC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate aminotransferase, PLP-dependent//ASPAMINOTRANS-RXN ) or ( aspartate aminotransferase, PLP-dependent//ASPAMINOTRANS-RXN ) or ( putative histidinol-phosphate aminotransferase//HISTAMINOTRANS-RXN ) or ( histidinol-phosphate aminotransferase//HISTAMINOTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4607_argH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERPHOSPHA__45__RXN" name="Phosphoserine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3477 ) or ( RHILE1049 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Phosphoserine phosphatase//Phosphoserine phosphatase ) or ( putative Sensory box histidine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phosphoserines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Serines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4OHBENZOATE__45__OCTAPRENYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1007_ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 4-hydroxybenzoate-octaprenyl transferase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALADENOSYLTRANS__45__RXN" name="Cob(I)alamin adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3019_btuR ) or ( RHILE4601 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)alamin and cobinamide ATP-dependent adenolsyltransferase//BTUR2-RXN//COBALADENOSYLTRANS-RXN ) or ( DUF80 )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COB__45__I__45__ALAMIN" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATESYNTH__45__RXN" name="dihydrofolate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0024_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: folylpolyglutamate synthase; dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16ALDOLASE__45__RXN" name="Fructose-bisphosphate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0800 ) or ( p12RHILE0028 ) or ( RHILE0684 ) or ( p12RHILE0201_cbbA ) or ( RHILE4285 ) or ( p11RHILE0166 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Fructose-bisphosphate aldolase//Fructose-bisphosphate aldolase ) or ( putative aldolase ) or ( putative Fructose-bisphosphate aldolase//Fructose-bisphosphate aldolase ) or ( fructose-bisphosphate aldolase ) or ( fructose-bisphosphate aldolase ) or ( putative aldolase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7607" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4353 ) or ( RHILE2172_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 5&apos;-NUCLEOTIDASE (SIGNAL PEPTIDE) PROTEIN (EC 3.1.3.5) ) or ( survival protein, protein damage control )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7609" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4353 ) or ( RHILE2172_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 5&apos;-NUCLEOTIDASE (SIGNAL PEPTIDE) PROTEIN (EC 3.1.3.5) ) or ( survival protein, protein damage control )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDAZOLONEPROPIONASE__45__RXN" name="Imidazolonepropionase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0223 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Imidazolonepropionase (EC 3.5.2.7) (Imidazolone-5-propionate hydrolase)//Imidazolonepropionase )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.7</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMIMINO__45__L__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPHOSPHOR__45__RXN" name="Guanosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0208_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.15</html:p>
<html:p>SIDE: RIBOSE__45__1P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYL__45__PHOSPHATASE__45__RXN" name="aryldialkyl phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0233 ) or ( RHILE3340 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Aryldialkylphosphatase//Aryldialkylphosphatase ) or ( putative Aryldialkylphosphatase//Aryldialkylphosphatase )</html:p>
<html:p>SUBSYSTEM: parathion degradation</html:p>
<html:p>SUBSYSTEM: superpathway of parathion degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1826" name="starch phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4393_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__662" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0536_areB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: p-cymene degradation to p-cumate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1002" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1003" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMACTRAN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2530_glmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal)//NAG1P-URIDYLTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLSPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1828" name="disproportionating enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0762 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 4-alpha-glucanotransferase//4-alpha-glucanotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4808 ) or ( RHILE3191 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)//Argininosuccinate synthase ) or ( Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)//Argininosuccinate synthase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__DEHYDRATASE__45__RXN" name="3-dehydroquinate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2215_aroQ2 ) or ( p11RHILE0079_aroQ2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-dehydroquinate dehydratase type 2//3-dehydroquinate dehydratase ) or ( 3-dehydroquinate dehydratase type 2//3-dehydroquinate dehydratase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: quinate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZYL__45__ALC__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0536_areB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STREPTOMYCIN__45__3__45__KINASE__45__RXN" name="Streptomycin 3&apos;&apos;-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3670 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Streptomycin 3&apos;&apos;-kinase (EC 2.7.1.87) (Streptomycin 3&apos;&apos;- phosphotransferase) (SPH)//Streptomycin 3&apos;&apos;-kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.87</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="STREPTOMYCIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__512" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTOX__45__RXN" name="Dihydroorotate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0606_pyrD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydro-orotate oxidase, FMN-linked//DIHYDROOROTOX-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINEPHEN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3244 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Copper methylamine oxidase precursor (EC 1.4.3.6) (MAOXII) )</html:p>
<html:p>SUBSYSTEM: phenylethylamine degradation</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLETHYLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALAMINSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2967_cobS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cobalamin 5&apos;-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.26</html:p>
<html:p>SIDE: GMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__RIBAZOLE" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R230__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0635 ) or ( p12RHILE0544 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ) or ( putative (R)-2-hydroxyacid dehydrogenase//(R)-2-hydroxyacid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: coenzyme M biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.272</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__367" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__380" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1823" name="&amp;alpha;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0747 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ALPHA-AMYLASE-RELATED PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Large__45__branched__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1825" name="&amp;alpha;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0747 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ALPHA-AMYLASE-RELATED PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7614" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0534 ) or ( p12RHILE0388 ) or ( RHILE1041_matB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acid-CoA ligase ) or ( putative O-succinylbenzoate--CoA ligase ) or ( malonyl CoA synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.26</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="O__45__SUCCINYLBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6972" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLMETHANOFURAN__45__DEHYDROGENASE__45__RXN" name="Formylmethanofuran dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0598 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative formyl-methanofuran dehydrogenase (GlxC) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Formyl__45__methanofurans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Methanofurans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__79__45__RXN" name="cyclopropane-fatty-acyl-phospholipid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2102_cfa1 ) or ( p12RHILE0607 ) or ( RHILE1004_cfa2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyclopropane-fatty-acyl-phospholipid synthase ) or ( putative cyclopropane-fatty-acyl-phospholipid synthase ) or ( cyclopropane-fatty-acyl-phospholipid synthase )</html:p>
<html:p>SUBSYSTEM: cyclopropane fatty acid (CFA) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.79</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phospholipid__45__Olefinic__45__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Phospholipid__45__Cyclopropane__45__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHBUTYRYL__45__COA__45__EPIM__45__RXN" name="3-hydroxybutyryl-CoA epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0629 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSALDOL__45__RXN" name="Transaldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4485_talB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transaldolase B//TRANSALDOL-RXN )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPDEHYDRHAMEPIM__45__RXN" name="dTDP-4-dehydrorhamnose 3,5-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1722_rfbC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-4,deoxyrhamnose 3,5 epimerase ) or ( dTDP-4-keto-6-deoxy-D-glucose-3,5-epimerase (fragment) )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCSEMIALDDEHYDROG__45__RXN" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0104_gabD ) or ( p12RHILE0046_gabD ) or ( p11RHILE0173 ) or ( p10RHILE0277_gabD ) or ( p12RHILE0663_gabD ) or ( p10RHILE0147_gabD ) or ( p12RHILE0637_gabD ) or ( RHILE3575 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( putative aldehyde dehydrogenase ) or ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( putative ALDEHYDE DEHYDROGENASE PROTEIN (EC 1.2.1.-) )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPH_TO_NADP_COF_RXN" name="NADPH_TO_NADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0024_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: folylpolyglutamate synthase; dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__77__45__RXN" name="Protein-L-isoaspartate(D-aspartate) O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0116 ) or ( p12RHILE0401 ) or ( RHILE2173_pcm ) or ( RHILE2154 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-isoaspartate protein carboxylmethyltransferase type II (modular protein) ) or ( putative Protein-L-isoaspartate(D-aspartate) O-methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase ) or ( L-isoaspartate protein carboxylmethyltransferase type II//2.1.1.77-RXN ) or ( putative Protein-L-isoaspartate(D-aspartate) O-methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.77</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOASPARTATES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CELLULOSE__45__SYNTHASE__45__UDP__45__FORMING__45__RXN" name="Cellulose synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1745 ) or ( RHILE0082 ) or ( RHILE0591 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cellulose synthase ) or ( putative Cellulose synthase (UDP-forming)//Cellulose synthase (UDP-forming) ) or ( putative cellulose synthase protein )</html:p>
<html:p>SUBSYSTEM: cellulose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.12</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACYLMANNOSAMINE__45__KINASE__45__RXN" name="N-acylmannosamine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0035 ) or ( RHILE4070 ) or ( p12RHILE0374 ) or ( RHILE3327 ) or ( RHILE4503 ) or ( p11RHILE0544 ) or ( RHILE0516 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glucose kinase ) or ( putative N-acylmannosamine kinase//N-acylmannosamine kinase ) or ( putative ROK family transcriptional regulator ) or ( putative ROK family transcriptional regulator ) or ( putative N-acylmannosamine kinase//N-acylmannosamine kinase ) or ( putative transcriptional regulator protein ) or ( putative TRANSCRIPTION REGULATOR PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.60</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1109" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__841" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__4__46__3__46__19__45__RXN" name="Glycine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3835 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glycine oxidase//Glycine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAMPYR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4233_serC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3OH__45__4P__45__OH__45__ALPHA__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHORYL__45__RXN" name="Phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4393_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDO__45__8PSYNTH__45__RXN" name="2-dehydro-3-deoxyphosphooctonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2373_kdsA ) or ( RHILE4444_eda )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-D-manno-octulosonic acid 8-P synthetase//KDO-8PSYNTH-RXN ) or ( multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase//KDPGALDOL-RXN//OXALODECARB-RXN )</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.55</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARABINOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO__45__8P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__12__46__18__45__RXN" name="Biphenyl 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1013 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Biphenyl 2,3-dioxygenase//Biphenyl 2,3-dioxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.18</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIPHENYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2R3S__45__3__45__PHENYLCYCLOHEXA__45__35__45__DIENE__45__12__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM2__45__RXN" name="Cytidine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0207 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) (CDA)//Cytidine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__99__46__25__45__RXN" name="Quinate dehydrogenase (pyrroloquinoline-quinone)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4095_quiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinate/shikimate dehydrogenase [Pyrroloquinoline-quinone] (NAD(P)-independent quinate dehydrogenase) )</html:p>
<html:p>SUBSYSTEM: quinate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.25</html:p>
<html:p>COFACTOR: PQQ</html:p>
<html:p>COFACTOR: CPD__45__104</html:p>
<html:p>SIDE: PQQ</html:p>
<html:p>SIDE: CPD__45__104</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP_TO_GTP_COF_RXN" name="GDP_TO_GTP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATE__45__REDUCTASE__45__NADH__45__RXN" name="nitrate reductase (NADH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0084 ) or ( RHILE3222 ) or ( RHILE4162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Sulfite oxidase ) or ( putative Nitrate reductase (NADPH)//Nitrate reductase (NADPH) ) or ( putative Nitrate reductase (NADH)//Nitrate reductase (NADH) )</html:p>
<html:p>SUBSYSTEM: nitrate reduction II (assimilatory)</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p12RHILE0665_aldH ) or ( p8RHILE0077 ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1408 ) or ( RHILE3423_ilvE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative branched-chain amino acid aminotransferase ) or ( putative branched-chain amino acid aminotransferase//BRANCHED-CHAINAMINOTRANSFERILEU-RXN//BRANCHED-CHAINAMINOTRANSFERLEU-RXN//BRANCHED-CHAINAMINOTRANSFERVAL-RXN )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__COUMAROYL__45__COA_TO_CO__45__A_COF_RXN" name="P-COUMAROYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="P__45__COUMAROYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREDEHYD__45__RXN" name="Threonine dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4328 ) or ( RHILE2072 ) or ( RHILE2709_sdaB ) or ( p12RHILE0054 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Threonine ammonia-lyase//Threonine ammonia-lyase ) or ( Threonine dehydratase biosynthetic (EC 4.3.1.19) (Threonine deaminase) ) or ( L-serine deaminase 2 ) or ( putative threonine dehydratase (EC 4.3.1.19) (Threonine deaminase) )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO___124__Fatty__45__Acyl__45__CoA__124___COF_RXN" name="CO-A_TO_|Fatty-Acyl-CoA|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHUROPORDEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2429 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative siroheme synthetase )</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.76</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTPDECARB__45__RXN" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0350_pyrF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( orotidine 5`-phosphate decarboxylase//OROTPDECARB-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.23</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2023" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4228_trmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__THIOURIDINE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRILE__45__HYDRATASE__45__RXN" name="Nitrile hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3463_nthB ) or ( p11RHILE0130 ) or ( RHILE3464_nthA ) or ( p11RHILE0129_nthA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative nitrile hydratase beta subunit ) or ( putative Low-molecular weight cobalt-containing nitrile hydratase subunit beta (EC 4.2.1.84) (L-nitrilase) (L-NHase) ) or ( nitrile hydratase alpha subunit ) or ( nitrile hydratase alpha subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nitriles__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROT__45__RXN" name="Dihydroorotase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1845_pyr ) or ( RHILE0521_pyrC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative noncatalytic chain of dihydroorotase ) or ( dihydro-orotase//DIHYDROOROT-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0105_goaG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase, PLP-dependent )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROG__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0082_glpD ) or ( p12RHILE0211_glpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sn-glycerol-3-phosphate dehydrogenase FAD/NAD(P)-binding (aerobic)//GLYC3PDEHYDROG-RXN//RXN0-5258 ) or ( sn-glycerol-3-phosphate dehydrogenase FAD/NAD(P)-binding (aerobic)//GLYC3PDEHYDROG-RXN//RXN0-5258 )</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donors reaction list</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)-- electron donors reaction list</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERALDEHYDE__45__DEHYDRO__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p8RHILE0077 ) or ( p12RHILE0665_aldH ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2602" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0393_mutM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formamidopyrimidine-DNA glycosylase//RXN0-2602 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.23</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Damaged__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__AP__45__Site__45__Created__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHD__45__RXN" name="Choline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1940_betA ) or ( p12RHILE0802_betA ) or ( p11RHILE0441 ) or ( RHILE1349_betA ) or ( p12RHILE0305 ) or ( p11RHILE0531 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline dehydrogenase, a flavoprotein//CHD-RXN ) or ( choline dehydrogenase, a flavoprotein//CHD-RXN ) or ( GMC-type oxidoreductase ) or ( choline dehydrogenase, a flavoprotein//CHD-RXN ) or ( putative oxidoreductase ) or ( Glucose-methanol-choline (GMC) oxidoreductase )</html:p>
<html:p>SUBSYSTEM: choline degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis I (Gram-negative bacteria)</html:p>
<html:p>SUBSYSTEM: choline-O-sulfate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLPHOSPHATASE__45__RXN" name="Acylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2879_yccX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acylphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acyl__45__Phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__901" name="Xanthine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3814_xdhA ) or ( p8RHILE0028_xdhA ) or ( RHILE2498 ) or ( RHILE3816 ) or (  ) or ( RHILE3815_xdhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase, small subunit ) or ( putative xanthine dehydrogenase subunit, molybdemum cofactor-binding domain ) or ( putative enzyme ) or ( putative xanthine dehydrogenase protein; xanthine dehydrogenase accessory factor (XdhC) ) or ( putative molybdemum cofactor-binding oxidoreductase (fragment) ) or ( xanthine dehydrogenase, large subunit )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2606" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0137_recR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gap repair protein with type I DNA topoisomerase domain, part of RecFOR complex that targets RecA to ssDNA-dsDNA junction )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Unstable__45__RecA__45__Filament__45__DNA__45__Complex__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Stabilized__45__RecA__45__Filament__45__DNA__45__Complex__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0028_xdhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative xanthine dehydrogenase subunit, molybdemum cofactor-binding domain )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1241" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4565_prmC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N5-glutamine methyltransferase, modifies release factors RF-1 and RF-2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N5__45__METHYLGLUTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOBUTDEHYDROG__45__RXN" name="Aminobutyraldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4476_ydcW )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: putrescine degradation V</html:p>
<html:p>SUBSYSTEM: putrescine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.19</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R222__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p8RHILE0077 ) or ( p12RHILE0665_aldH ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: octane oxidation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__371" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7082" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0363 ) or ( RHILE4450 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Beta-glucosidase (EC 3.2.1.21) (Gentiobiase) (Cellobiase) (Beta-D- glucoside glucohydrolase)//Beta-glucosidase ) or ( Beta-glucosidase (EC 3.2.1.21) (Gentiobiase) (Cellobiase) (Beta-D- glucoside glucohydrolase) (Amygdalase)//Beta-glucosidase )</html:p>
<html:p>SUBSYSTEM: DIMBOA-glucoside degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6562" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__6366" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOCATECHUATE__45__3__45__4__45__DIOXYGENASE__45__RXN" name="Protocatechuate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0090_pcaH ) or ( p11RHILE0089_pcaG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protocatechuate 3,4-dioxygenase beta chain (3,4-PCD) ) or ( protocatechuate 3,4-dioxygenase alpha chain (3,4-PCD) )</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__183" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__184" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__54__45__RXN" name="Precorrin-6X reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0676_cobK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Precorrin-6A reductase//Precorrin-6A reductase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.54</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__675" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__679" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__SYN__45__RXN" name="glutathione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0357_gshB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione synthetase//GLUTATHIONE-SYN-RXN )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7644" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0544 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ZINC-TYPE ALCOHOL DEHYDROGENASE PROTEIN (EC 1.1.1.-) )</html:p>
<html:p>SUBSYSTEM: sorbitol utilization</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALAMIN5PSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2967_cobS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cobalamin 5&apos;-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.26</html:p>
<html:p>SIDE: GMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__RIBAZOLE__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__NUCLEOTID__45__RXN" name="3&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2172_surE ) or ( RHILE2080_cpdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( survival protein, protein damage control ) or ( 2&apos;:3&apos;-cyclic-nucleotide 2&apos;-phosphodiesterase//CYCPHOSDIESTER-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEHYDROG__45__RXN" name="Homoserine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2222_HDH ) or ( p8RHILE0078 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative homoserine dehydrogenase ) or ( Homoserine dehydrogenase family protein//Homoserine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALA__45__GLU__45__LIG__45__RXN" name="UDP-N-acetylmuramoylalanine--D-glutamate ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3539_murD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanine-D-glutamate ligase//UDP-NACMURALA-GLU-LIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__ACETYLMURAMOYL__45__ALA" stoichiometry="1"/>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLALANINE__45__4__45__MONOOXYGENASE__45__RXN" name="Phenylalanine 4-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1972 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phenylalanine-4-hydroxylase (EC 1.14.16.1) (PAH) (Phe-4- monooxygenase) )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.1</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITLY__45__RXN" name="Citrate lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0322 ) or ( RHILE4998 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative citrate lyase beta chain ) or ( putative Citrate (pro-3S)-lyase//Citrate (pro-3S)-lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSPH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0394 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Cystathionine gamma-synthase//Cystathionine gamma-synthase )</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHAMLY__45__RXN" name="Ethanolamine ammonia-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4656_eutC ) or ( RHILE4655_eutB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ethanolamine ammonia-lyase, light chain//ETHAMLY-RXN ) or ( ethanolamine ammonia-lyase, heavy chain//ETHAMLY-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KANAMYCIN__45__KINASE__45__RXN" name="Kanamycin kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3633 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aminoglycoside 3&apos;-phosphotransferase (EC 2.7.1.95) (Kanamycin kinase, type II) (Neomycin-kanamycin phosphotransferase, type II) (APH(3&apos;)II)//Kanamycin kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.95</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Kanamycins__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Kanamycin__45__3__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATESYN__45__RXN" name="Thymidylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3484_thyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate synthetase//THYMIDYLATESYN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.45</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: DIHYDROFOLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLULOKIN__45__RXN" name="Xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4459_xylB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylulokinase )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>SUBSYSTEM: xylose degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCULOKIN__45__RXN" name="L-fuculokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0444 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RhaK )</html:p>
<html:p>SUBSYSTEM: fucose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.51</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__FUCULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUCULOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOESTER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2795 ) or ( RHILE4861_tesB ) or ( RHILE4823_tesA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acyl-CoA thioesterase ) or ( acyl-CoA thioesterase II ) or ( multifunctional: acyl-CoA thioesterase I; protease I; lysophospholipaseL(I)//LYSOPHOSPHOLIPASE-RXN )</html:p>
<html:p>SUBSYSTEM: acyl-CoA hydrolysis</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Saturated__45__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1041" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2427_mazG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( conserved hypothetical protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__280" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0437_ssuD ) or ( RHILE2954_ssuD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alkanesulfonate monooxygenase, FMNH(2)-dependent ) or ( alkanesulfonate monooxygenase, FMNH(2)-dependent )</html:p>
<html:p>SUBSYSTEM: two-component alkanesulfonate monooxygenase</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.5</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alkanesulfonates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R__45__6__45__HYDROXYNICOTINE__45__OXIDASE__45__RXN" name="(R)-6-hydroxynicotine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2848 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__6__45__HYDROXYNICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2044" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0394_paaF ) or ( p12RHILE0072_paaF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) )</html:p>
<html:p>SUBSYSTEM: phenylacetate degradation I</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYADIPYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__" stoichiometry="2"/>
      <speciesReference species="_3__45__KETO__45__ADIPYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOKINASE__45__RXN" name="Fructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0680 ) or ( p8RHILE0088 ) or ( RHILE1586 ) or ( RHILE0530 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Fructokinase//Fructokinase ) or ( putative FRUCTOKINASE PROTEIN (EC 2.7.1.4) ) or ( Myo-inositol catabolism; IolC ) or ( Fructokinase (EC 2.7.1.4)//Fructokinase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7657" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0328 ) or ( p12RHILE0464 ) or ( p9RHILE0032_adhP ) or ( RHILE1990 ) or ( p10RHILE0115 ) or ( p10RHILE0129 ) or ( RHILE1407 ) or ( p9RHILE0106 ) or ( p10RHILE0148 ) or ( p12RHILE0555_adhC ) or (  ) or ( p12RHILE0636 ) or ( RHILE3574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alcohol dehydrogenase, propanol-preferring ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase, propanol-preferring//ALCOHOL-DEHYDROG-GENERIC-RXN//ALCOHOL-DEHYDROG-RXN ) or ( putative Zn-containing alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase ) or ( putative OXIDOREDUCTASE TRANSMEMBRANE PROTEIN ) or ( Alcohol dehydrogenase (EC 1.1.1.1)//Alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase class III ) or ( putative iron-containing alcohol dehydrogenase (fragment) ) or ( Alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7000" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOBUTANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1673_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__12__45__DIOXYGENASE__45__RXN" name="Catechol 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0104 ) or ( p12RHILE0220 ) or ( p12RHILE0096 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Catechol 1,2-dioxygenase//Catechol 1,2-dioxygenase ) or ( putative Catechol 1,2-dioxygenase//Catechol 1,2-dioxygenase ) or ( putative Catechol 1,2-dioxygenase//Catechol 1,2-dioxygenase )</html:p>
<html:p>SUBSYSTEM: catechol degradation to &amp;beta;-ketoadipate</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.1</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__CIS__45__MUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DADP_TO_DATP_COF_RXN" name="DADP_TO_DATP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="DADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOINDEHYDROG__45__A__45__RXN" name="Acetoin dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0091 ) or ( p11RHILE0087_idnO ) or ( p10RHILE0426_idnO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Acetoin dehydrogenase, alpha/beta subunit ) or ( 5-keto-D-gluconate-5-reductase//GLUCONATE-5-DEHYDROGENASE-RXN ) or ( 5-keto-D-gluconate-5-reductase//GLUCONATE-5-DEHYDROGENASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEHYDDEOXGALACTKIN__45__RXN" name="2-dehydro-3-deoxygalactonokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0967_dgoK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-oxo-3-deoxygalactonate kinase//DEHYDDEOXGALACTKIN-RXN )</html:p>
<html:p>SUBSYSTEM: D-galactonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.58</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GALACTONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDRO__45__DEOXY__45__GALACTONATE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2625" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0429_mutS ) or ( RHILE0961_mutL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA mismatch repair protein mutS ) or ( DNA mismatch repair protein MutL )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8199" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8200" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__99__46__16__45__RXN" name="Maltose &amp;alpha;-D-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0748 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative trehalose synthase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHLBXANAU__45__RXN" name="2-haloacid dehalogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0654 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-haloacid halidohydrolase IVa )</html:p>
<html:p>SUBSYSTEM: 1,2-dichloroethane degradation pathway</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROACETIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3244 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Copper methylamine oxidase precursor (EC 1.4.3.6) (MAOXII) )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VI (via tryptamine)</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__SYNTHASE__45__RXN" name="3-dehydroquinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4639_aroB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydroquinate synthase//3-DEHYDROQUINATE-SYNTHASE-RXN )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2622" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2224_recJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( conserved hypothetical protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8180" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8181" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2621" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1680_uvrC ) or ( RHILE3158_uvrB ) or ( RHILE2547_uvrA ) or ( RHILE3505_uvrD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA exisiton repair enzyme together with UvrAB ) or ( putative excinuclease ABC subunit B ) or ( DNA excision repair enzyme subunit, with UvrBC ) or ( DNA helicase II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.25-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8180" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8534" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2624" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4262_ruvB ) or ( RHILE4261_ruvA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Holliday junction helicase, subunit B ) or ( Holliday junction helicase, subunit A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.22.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__Combined__45__With__45__Exogenous__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Resolution__45__of__45__Recombinational__45__Junction__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1404" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0698 ) or ( p8RHILE0083 ) or ( p12RHILE0465 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aliphatic nitrilase (EC 3.5.5.7) ) or ( putative nitrilase ) or ( Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase//Nitrilase )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLEYL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__275" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0131_hyuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylhydantoinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLHYDANTOIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8524" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRTRANS__45__RXN" name="Anthranilate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2654_trpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anthranilate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2081" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2109_nasA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrate reductase, large subunit )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)-- electron acceptors reaction list</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.4</html:p>
<html:p>SIDE: UBIQUINOL__45__10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UBIQUINONE__45__10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
      <speciesReference species="UBIQUINOL__45__10" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__10" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TEICHOICSYN2__45__RXN" name="N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-&amp;beta;-D- mannosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0153 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D- mannosaminyltransferase//N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D- mannosaminyltransferase ) or ( CpsF (Fragment) (modular protein) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.187</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__D__45__GLUCOSAMINYLDIPHOSPHO__45__UNDECAPRE" stoichiometry="1"/>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__ETCETERA__45__GLUCOSAMINYLDIPHOSPHOUND" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULOSE__45__BISPHOSPHATE__45__CARBOXYLASE__45__RXN" name="Ribulose-bisphosphate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0419 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ribulose bisphosphate carboxylaseoxygenase, large subunit protein (EC 4.1.1.39) )</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.39</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__RIBULOSE__45__15__45__P2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCINYLBENZOATE__45__COA__45__LIG__45__RXN" name="O-succinylbenzoate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0534 ) or ( p12RHILE0388 ) or ( RHILE1041_matB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acid-CoA ligase ) or ( putative O-succinylbenzoate--CoA ligase ) or ( malonyl CoA synthetase )</html:p>
<html:p>SUBSYSTEM: menaquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.26</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__SUCCINYLBENZOATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYLBENZOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYBENZOATE__45__3__45__MONOOXYGENASE__45__RXN" name="4-hydroxybenzoate 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4174_phbH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybenzoate hydroxylase (4-hydroxybenzoate-3-monooxygenase) )</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7669" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2564 ) or ( p12RHILE0749_glgB ) or ( RHILE4394_glgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 1,4-alpha-glucan branching enzyme//1,4-alpha-glucan branching enzyme ) or ( 1,4-alpha-glucan branching enzyme ) or ( 1,4-alpha-glucan branching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis II (from UDP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOINDEHYDROG__45__RXN" name="acetoin dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0091 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Acetoin dehydrogenase, alpha/beta subunit )</html:p>
<html:p>SUBSYSTEM: butanediol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.5</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTSEMIALDEHYDROG__45__RXN" name="Glutamate-5-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4978_proA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamylphosphate reductase//GLUTSEMIALDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1461" name="Coproporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3732_hemF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( coproporphyrinogen III oxidase//RXN0-1461 )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVFORMLY__45__RXN" name="Formate C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4816_yfgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative pyruvate formate lyase activating enzyme 2 )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: reductive monocarboxylic acid cycle</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to ethanol I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.54</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEME__45__OXYGENASE__45__DECYCLIZING__45__RXN" name="Heme oxygenase (decyclizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3968 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative heme oxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIVERDINE" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__10__46__2__45__RXN" name="Non-specific protein-tyrosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4084 ) or ( p9RHILE0001 ) or ( p7RHILE0001 ) or ( RHILE3915 ) or ( p9RHILE0143 ) or ( p7RHILE0089 ) or ( RHILE5032_parA ) or ( p8RHILE0001 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Protein-tyrosine kinase ) or ( putative replication protein A ) or ( putative replication protein A ) or ( Succinoglycan biosynthesis transport protein exoP ) or ( putative Protein-tyrosine kinase ) or ( putative replication protein A ) or ( chromosome partitioning protein, ParA ) or ( putative replication protein A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.10.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__2__46__10__45__RXN" name="Phosphoglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4236_glmM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglucosamine mutase )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSAMINE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSMANMUT__45__RXN" name="Phosphomannomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3927 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannose-1-phosphate guanyltransferase, colanic acid synthesis (modular protein) )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__268" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0035_ygfH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( propionyl-CoA:succinate-CoA transferase )</html:p>
<html:p>SUBSYSTEM: conversion of succinate to propionate</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>SIDE: PROPIONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAZIN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3508_pncA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinamidase/pyrazinamidase//NICOTINAMID-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRAZINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRAZINOIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMIDASE__45__RXN" name="Amidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2201_GatA2 ) or ( p9RHILE0215 ) or ( p11RHILE0464 ) or ( RHILE0232 ) or ( p12RHILE0140 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( putative amidase ) or ( Glutamyl-tRNA amidotransferase subunit A ) or ( putative amidase ) or ( putative AMIDASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Monocarboxylic__45__Acid__45__Amides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Monocarboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__262" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2913_mobA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( molybdopterin-guanine dinucleotide synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="CPD__45__4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__582" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__37" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p8RHILE0077 ) or ( p12RHILE0665_aldH ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__30" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__35" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__34" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4675_rocF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative arginase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7682" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3814_xdhA ) or ( RHILE2498 ) or ( RHILE3816 ) or (  ) or ( RHILE3815_xdhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase, small subunit ) or ( putative enzyme ) or ( putative xanthine dehydrogenase protein; xanthine dehydrogenase accessory factor (XdhC) ) or ( putative molybdemum cofactor-binding oxidoreductase (fragment) ) or ( xanthine dehydrogenase, large subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPRIBOSYLTRAN__45__RXN" name="Adenine phosphoribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3721_apt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.7</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1603" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__409" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__504" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPRIBOSYLTRAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2067_gpt ) or ( RHILE4612 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine-hypoxanthine phosphoribosyltransferase//XANPRIBOSYLTRAN-RXN ) or ( Hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) (HPRT)//Hypoxanthine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DMBPPRIBOSYLTRANS__45__RXN" name="Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2966_cobT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate-nucleotide dimethylbenzimidazole-P phophoribosyl transferase//DMBPPRIBOSYLTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.21</html:p>
<html:p>SIDE: NIACINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
      <speciesReference species="DIMETHYLBENZIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__RIBAZOLE__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINALOOL__45__8__45__MONOOXYGENASE__45__RXN" name="Linalool 8-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1789 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Linalool 8-monooxygenase//Linalool 8-monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.28</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_37__45__DIMETHYLOCTA__45__16__45__DIEN__45__3__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__37__45__DIMETHYLOCTA__45__16__45__DIEN__45__38__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__600" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0322 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cinnamoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.219</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__474" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__590" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0282 ) or ( RHILE3568 ) or ( p10RHILE0127 ) or ( RHILE1585 ) or ( p10RHILE0128 ) or (  ) or (  ) or ( p10RHILE0063_ilvB ) or ( p12RHILE0127 ) or ( RHILE2598_ilvI ) or ( RHILE3469_ilvH ) or ( RHILE3470_ilvI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetolactate synthase large subunit//Acetolactate synthase ) or ( putative Acetolactate synthase//Acetolactate synthase ) or ( putative Acetolactate synthase//Acetolactate synthase ) or ( putative malonic semialdehyde oxidative decarboxylase (EC 1.-.-.-) ) or ( putative Acetolactate synthase//Acetolactate synthase ) or ( Acetolactate synthase large subunit (fragment)//Acetolactate synthase ) or ( Acetolactate synthase large subunit (fragment)//Acetolactate synthase ) or ( putative acetolactate synthase large subunit ) or ( Thiamine pyrophosphate enzyme ) or ( acetolactate synthase III, valine-sensitive, large subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN ) or ( acetolactate synthase III, valine-sensitive, small subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN ) or ( acetolactate synthase III, valine-sensitive, large subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNN__45__404" name="indole acetamide hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2201_GatA2 ) or ( p9RHILE0215 ) or ( p11RHILE0464 ) or ( RHILE0232 ) or ( p12RHILE0140 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( putative amidase ) or ( Glutamyl-tRNA amidotransferase subunit A ) or ( putative amidase ) or ( putative AMIDASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__237" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Homoserine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0150 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Homoserine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: homocysteine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.31</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBPSYN__45__RXN" name="carbamoyl-phosphate synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3647_carA ) or ( RHILE3655_carB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbamoyl phosphate synthetase, glutamine amidotransferase small subunit//CARBPSYN-RXN ) or ( carbamoyl phosphate synthase, large subunit//CARBPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FARNESYLTRANSTRANSFERASE__45__RXN" name="Farnesyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0988_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: geranylgeranyldiphosphate biosynthesis II (plastidic)</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.29</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOHEMEFERROCHELAT__45__RXN" name="Ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4354_hemH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferrochelatase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDROG__45__RXN" name="Prephenate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4621_tyrC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Prephenate dehydrogenase//Prephenate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOHMETRANS__45__RXN" name="glycine hydroxymethyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1715_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.1</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREONINE__45__ALDOLASE__45__RXN" name="Threonine aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4364 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Low-specificity L-threonine aldolase (EC 4.1.2.5) (Low-specificity L- TA) )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>SIDE: ACETALD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RFFTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0838_rffA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TDP-4-oxo-6-deoxy-D-glucose transaminase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.-</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP__45__D__45__FUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7800" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHGLYSYN__45__RXN" name="Methylglyoxal synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0189 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Methylglyoxal synthase (EC 4.2.3.3) (MGS)//Methylglyoxal synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__PYRONE__45__46__45__DICARBOXYLATE__45__LACTONASE__45__RXN" name="2-pyrone-4,6-dicarboxylate lactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4714 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-pyrone-4,6-dicarboxylate hydrolase )</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.57</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__184" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__185" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1941" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0123 ) or ( p12RHILE0111 ) or ( RHILE4852_dkgA ) or ( RHILE1798 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxidoreductase ) or ( putative oxidoreductase (EC 1.1.1.21) ) or ( 2,5-diketo-D-gluconate reductase A//1.1.1.274-RXN//RXN0-1941 ) or ( putative OXIDOREDUCTASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.274</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHYL__45__2__45__METHYLACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHYL__45__2R__45__METHYL__45__3S__45__HYDROXYBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5289" name="2-hydroxy-3-oxopropionate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4062_glxR ) or ( RHILE4034_glxR ) or ( RHILE2957 ) or ( p10RHILE0428 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tartronic semialdehyde reductase//TSA-REDUCT-RXN ) or ( tartronic semialdehyde reductase//TSA-REDUCT-RXN ) or ( 3-hydroxyisobutyrate dehydrogenase ) or ( putative 2-hydroxy-3-oxopropionate reductase//2-hydroxy-3-oxopropionate reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation (E. coli)</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.60</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITDEH__45__RXN" name="Isocitrate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2808_idh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THRESYN__45__RXN" name="Threonine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1112_thrC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine synthase )</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOGLYCOSIDE__45__N6__45__ACETYLTRANSFERASE__45__RXN" name="Kanamycin 6&apos;-N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0050 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aminoglycoside 6&apos;-N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.82</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4822" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N6__45__ACETYLKANAMYCIN__45__B" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4617_plsC ) or ( RHILE0417 ) or ( p9RHILE0212 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 1-acylglycerol-3-phosphate O-acyltransferase//1-ACYLGLYCEROL-3-P-ACYLTRANSFER-RXN//1-acylglycerol-3-phosphate O-acyltransferase ) or ( putative ACYLTRANSFERASE TRANSMEMBRANE PROTEIN (EC 2.3.1.-) ) or ( putative acyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.51</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA__45__CARBOXYLTRANSFER__45__RXN" name="Acetyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2214_accB ) or ( RHILE4643_accA ) or ( p10RHILE0472_accB ) or ( RHILE0023_accD ) or ( p12RHILE0155_accC ) or ( p10RHILE0471_accC ) or ( RHILE2213_accC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit ) or ( acetylCoA carboxylase, carboxytransferase subunit alpha//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055 ) or ( acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit ) or ( acetylCoA carboxylase, carboxyltranferase subunit beta//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055 ) or ( acetyl CoA carboxylase, biotin carboxylase subunit//BIOTIN-CARBOXYL-RXN ) or ( acetyl CoA carboxylase, biotin carboxylase subunit//BIOTIN-CARBOXYL-RXN ) or ( acetyl CoA carboxylase, biotin carboxylase subunit//BIOTIN-CARBOXYL-RXN )</html:p>
<html:p>SUBSYSTEM: fatty acid biosynthesis - initial steps I</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1408 ) or ( RHILE3423_ilvE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative branched-chain amino acid aminotransferase ) or ( putative branched-chain amino acid aminotransferase//BRANCHED-CHAINAMINOTRANSFERILEU-RXN//BRANCHED-CHAINAMINOTRANSFERLEU-RXN//BRANCHED-CHAINAMINOTRANSFERVAL-RXN )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5293" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0104_gabD ) or ( p12RHILE0046_gabD ) or ( p11RHILE0173 ) or ( p10RHILE0277_gabD ) or ( p12RHILE0663_gabD ) or ( p10RHILE0147_gabD ) or ( RHILE3575 ) or ( p12RHILE0637_gabD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( putative aldehyde dehydrogenase ) or ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN ) or ( putative ALDEHYDE DEHYDROGENASE PROTEIN (EC 1.2.1.-) ) or ( succinate-semialdehyde dehydrogenase I, NADP-dependent//SUCCSEMIALDDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OPPSYN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0988_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTPRATPHYD__45__RXN" name="Phosphoribosyl-ATP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoribosyl-ATP pyrophosphatase (fragment) )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__3__46__3__46__10__45__RXN" name="5-carboxymethyl-2-hydroxymuconate &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0016 ) or ( RHILE3392 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase ) or ( Fumarylacetoacetate (FAA) hydrolase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__784" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__785" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxyisobutyrate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2957 ) or ( p11RHILE0158 ) or ( p11RHILE0442 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyisobutyrate dehydrogenase ) or ( 3-hydroxyisobutyrate dehydrogenase family protein//3-hydroxyisobutyrate dehydrogenase ) or ( 3-hydroxyisobutyrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.31</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BHBDCLOS__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0330 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-hydroxyacyl-CoA dehydrogenase//3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate I</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYT__45__UBIQUINOL__45__OXID__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0041_cyoD ) or ( p9RHILE0290_cydA ) or ( RHILE3251_cyoC ) or ( RHILE1072_cyoB ) or ( p9RHILE0291_appB ) or ( p11RHILE0043_cyoB ) or ( p11RHILE0042_cyoC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome o ubiquinol oxidase subunit IV ) or ( cytochrome d terminal oxidase, polypeptide subunit I ) or ( cytochrome o ubiquinol oxidase, subunit III ) or ( cytochrome o ubiquinol oxidase, subunit I ) or ( cytochrome oxidase bd-II, subunit II ) or ( cytochrome o ubiquinol oxidase, subunit I ) or ( cytochrome o ubiquinol oxidase, subunit III )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDPHOSDEHYD__45__RXN" name="Imidazoleglycerol-phosphate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0048_hisB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( imidazoleglycerol-phosphate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TAGAALDOL__45__RXN" name="Tagatose-bisphosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0258_kbaZ ) or ( RHILE0681_kbaZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tagatose 6-phosphate aldolase 1, subunit together with AgaY//TAGAALDOL-RXN ) or ( tagatose 6-phosphate aldolase 1, subunit together with AgaY//TAGAALDOL-RXN )</html:p>
<html:p>SUBSYSTEM: galactitol degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.40</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAGATOSE__45__1__45__6__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Aspartate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5010_asdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate-semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.11</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPPYPHOSKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1597_spoT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: (p)ppGpp synthetase II; guanosine-3&apos;,5&apos;-bis pyrophosphate 3&apos;-pyrophosphohydrolase//GDPPYPHOSKIN-RXN//PPGPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE__45__5DP__45__3DP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLMALONYL__45__COA__45__MUT__45__RXN" name="Methylmalonyl-CoA mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0311_yliK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonyl-CoA mutase (MCM)//METHYLMALONYL-COA-MUT-RXN )</html:p>
<html:p>SUBSYSTEM: conversion of succinate to propionate</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Protein__45__Dithiols__124___TO___124__Protein__45__Disulfides__124___COF_RXN" name="|Protein-Dithiols|_TO_|Protein-Disulfides|_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Dithiols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LCYSDESULF__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2341_metC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-lyase, PLP-dependent (beta-cystathionase)//CYSTATHIONINE-BETA-LYASE-RXN )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAPASYN__45__RXN" name="Adenosylmethionine--8-amino-7-oxononanoate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1555 ) or ( p12RHILE0045 ) or ( p12RHILE0646 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aminotransferase y4uB (EC 2.6.1.-) ) or ( putative aminotransferase y4uB (EC 2.6.1.-) ) or ( putative aminotransferase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis III</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.62</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_8__45__AMINO__45__7__45__OXONONANOATE" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOSE__45__6__45__PHOSPHATE__45__ISOMERASE__45__RXN" name="Galactose-6-phosphate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0216 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sugar-phosphate isomerases, RpiB/LacA/LacB family )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1241" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAGATOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE1EPIM__45__RXN" name="ALDOSE-1-EPIMERASE" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4900 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase)//Aldose 1-epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7421" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2102_cfa1 ) or ( p12RHILE0607 ) or ( RHILE1004_cfa2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyclopropane-fatty-acyl-phospholipid synthase ) or ( putative cyclopropane-fatty-acyl-phospholipid synthase ) or ( cyclopropane-fatty-acyl-phospholipid synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.79</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSTERCULIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANPRIBOSYLTRAN__45__RXN" name="Xanthine-guanine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2067_gpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine-hypoxanthine phosphoribosyltransferase//XANPRIBOSYLTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.22</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UNDECAPRENOL__45__KINASE__45__RXN" name="Undecaprenol kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0347 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Undecaprenyl-diphosphatase (EC 3.6.1.27) (Undecaprenyl pyrophosphate phosphatase) (Bacitracin resistance protein) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.66</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__188" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIPHENYL__45__23__45__DIOL__45__12__45__DIOXYGENASE__45__RXN" name="Biphenyl-2,3-diol 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BIPHENYL-2,3-DIOL 1,2-DIOXYGENASE III (EC 1.13.11.39) (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.39</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIPHENYL__45__23__45__DIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOPRIBOTRANS__45__RXN" name="Nicotinate-nucleotide pyrophosphorylase (carboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0664_nadC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinolinate phosphoribosyltransferase//QUINOPRIBOTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.19</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNREDUC__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1717 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative RIBOFLAVIN BIOSYNTHESIS PROTEIN (Riboflavin-specific deaminase/reductase) (EC 3.5.4.26) (EC 1.1.1.193) )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.193</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1086" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8567" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7650" stoichiometry="1"/>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8757" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__P__45__OR__45__NOP_TO_NADH__45__P__45__OR__45__NOP_COF_RXN" name="NAD-P-OR-NOP_TO_NADH-P-OR-NOP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3084_arsC ) or ( RHILE3081_arsC3 ) or ( RHILE0652_arsC4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arsenate reductase//RXN-982 ) or ( arsenate reductase ) or ( putative arsenate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__296" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOIC__45__ACID" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__763" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__17__45__RXN" name="L-serine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5002 ) or ( RHILE2709_sdaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-serine dehydratase (EC 4.3.1.17) (L-serine deaminase) ) or ( L-serine deaminase 2 )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: L-serine degradation</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAM__45__RXN" name="Phosphoserine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4233_serC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSGLYPHOS__45__RXN" name="Phosphoglycerate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4284_pgk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7839" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1964 ) or ( p12RHILE0535_hcaA ) or ( RHILE1778 ) or ( RHILE0394_paaF ) or ( RHILE1933_dcaE ) or ( RHILE0641 ) or ( p12RHILE0072_paaF ) or ( p12RHILE0178 ) or ( RHILE1017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Enoyl-CoA hydratase//Enoyl-CoA hydratase ) or ( enoyl-CoA hydratase/lyase ) or ( putative enoyl-CoA hydratase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( enoyl-CoA hydratase ) or ( putative enoyl-CoA hydratase protein (EC 4.2.1.17) ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative dihydroxynaphthoic acid synthetase ) or ( putative enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__23__45__RXN" name="Acylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3565 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Acylglycerol lipase//Acylglycerol lipase )</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Fatty__45__Acids__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__504" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7835" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0536 ) or ( p12RHILE0550 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2,4-dienoyl-CoA reductase (NADPH)//2,4-dienoyl-CoA reductase (NADPH) ) or ( putative N-methylproline demethylase (EC 1.-.-.-) (Stachydrine utilization protein stcD) )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__trans__45__4__45__cis__45__dienoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTPSYN__45__RXN" name="CTP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2673_pyrG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CTP synthetase//CTPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7838" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1964 ) or ( p12RHILE0535_hcaA ) or ( RHILE1778 ) or ( RHILE1933_dcaE ) or ( RHILE0394_paaF ) or ( RHILE0641 ) or ( p12RHILE0178 ) or ( p12RHILE0072_paaF ) or ( RHILE1017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Enoyl-CoA hydratase//Enoyl-CoA hydratase ) or ( enoyl-CoA hydratase/lyase ) or ( putative enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase protein (EC 4.2.1.17) ) or ( putative dihydroxynaphthoic acid synthetase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cis__45__2__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNDEACET__45__RXN" name="Acetylornithine deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0668 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine deacetylase (EC 3.5.1.16)//Acetylornithine deacetylase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROPORIIIMETHYLTRANSA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2429 ) or ( RHILE3013 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative siroheme synthetase ) or ( Uroporphyrin-III C-methyltransferase (EC 2.1.1.107) (Urogen III methylase) (SUMT) (Uroporphyrinogen III methylase) (UROM) )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__GLN__45__RXN" name="NAD(+) synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2871_nadE ) or ( RHILE1415_nadE ) or ( RHILE2995 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NH3-dependent NAD synthetase ) or ( NAD synthetase, prefers NH3 over glutamine//NAD-SYNTH-NH3-RXN ) or ( putative NAD(+) synthase (glutamine-hydrolyzing)//NAD(+) synthase (glutamine-hydrolyzing) )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UREIDOGLYCOLATE__45__HYDROLASE__45__RXN" name="Ureidoglycolate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3830_allA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ureidoglycolate amidohydrolase(decarboxylating)//UREIDOGLYCOLATE-HYDROLASE-RXN )</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__18__45__RXN" name="&amp;beta;-alanine--pyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3779 ) or ( p12RHILE0443 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-alanine-pyruvate transaminase ) or ( beta-alanine-pyruvate transaminase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine degradation II</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.18</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLTHFGLUSYNTH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0024_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: folylpolyglutamate synthase; dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8581" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0536_areB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: p-xylene degradation to p-toluate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__METHYLBENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8773" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8580" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0536_areB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: m-xylene degradation to m-toluate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYLBENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8774" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8775" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0243 ) or ( RHILE2437 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-ketoglutarate semialdehyde dehydrogenase ) or ( 2-ketoglutarate semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.26</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__654" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7001" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0208_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARSENATE" stoichiometry="1"/>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5234" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1715_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLO__45__THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_25__45__DIOXOVALERATE__45__DEHYDROGENASE__45__RXN" name="2,5-dioxovalerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0243 ) or ( RHILE2437 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-ketoglutarate semialdehyde dehydrogenase ) or ( 2-ketoglutarate semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.26</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__654" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Acceptor__124___TO___124__Donor__45__H2__124___COF_RXN" name="|Acceptor|_TO_|Donor-H2|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMP__45__DEHYDROG__45__RXN" name="IMP dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0894_guaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IMP dehydrogeanse//IMP-DEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.205</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XMPXAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4353 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 5&apos;-NUCLEOTIDASE (SIGNAL PEPTIDE) PROTEIN (EC 3.1.3.5) )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MMUM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0448 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative homocysteine S-methyltransferase family protein )</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.10</html:p>
<html:p>SIDE: CPD__45__397</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="CPD__45__397" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__40__45__RXN" name="(R)-3-amino-2-methylpropionate--pyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0240 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aminotransferase, class III )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.40</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__471" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKANAL__45__MONOOXYGENASE__45__FMN__45__LINKED__45__RXN" name="Alkanal monooxygenase (FMN-linked)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3358 ) or ( RHILE3805 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alkanal monooxygenase (LuxA-like protein) ) or ( putative Alkanal monooxygenase (FMN-linked)//Alkanal monooxygenase (FMN-linked) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.3</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__268" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5240" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1715_glyA ) or ( RHILE1641 ) or ( p12RHILE0440_dadX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) or ( putative alanine racemase ) or ( alanine racemase 2, PLP-binding, catabolic//ALARACECAT-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINYLDIAMINOPIMTRANS__45__RXN" name="Succinyldiaminopimelate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0582_argD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylornithine transaminase (NAcOATase and DapATase), PLP-dependent//ACETYLORNTRANSAM-RXN//SUCCINYLDIAMINOPIMTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.17</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__SUCCINYL__45__2__45__AMINO__45__6__45__KETOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__SUCCINYLLL__45__2__45__6__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8783" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0304 ) or ( RHILE4522 ) or ( p10RHILE0422 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative gluconolactonase (EC 3.1.1.17) (modular protein) ) or ( putative gluconolactonase protein (EC 3.1.1.17) ) or ( putative Gluconolactonase//Gluconolactonase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GULONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHITIN__45__DEACETYLASE__45__RXN" name="Chitin deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0204 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Chitooligosaccharide deacetylase (EC 3.5.1.-) (Nodulation protein B) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.41</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_14__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYLN1" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__Chitosan__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__200" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__47__45__RXN" name="2-acetyl-1-alkylglycerophosphocholine esterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0704 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 1-alkyl-2-acetylglycerophosphocholine esterase//1-alkyl-2-acetylglycerophosphocholine esterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.47</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alkyl__45__acetyl__45__glycero__45__phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__1__45__Alkyl__45__sn__45__glycero__45__3__45__phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3PGAREARR__45__RXN" name="Phosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1060 ) or ( RHILE2844 ) or ( RHILE0185_gpmA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoglycerate mutase ) or ( putative Phosphoglycerate mutase//Phosphoglycerate mutase ) or ( phosphoglyceromutase 1//3PGAREARR-RXN )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSEPHOSPHA__45__RXN" name="Trehalose-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0506 ) or ( RHILE1750_yfbT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative trehalose-phosphatase (EC 3.1.3.12) (Trehalose 6-phosphate phosphatase) (TPP) ) or ( putative phosphatase, contains a phosphatase-like domain )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis II</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis III</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLGLUTPREDUCT__45__RXN" name="N-acetyl-&amp;gamma;-glutamyl-phosphate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1771_argC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglutamate semialdehyde dehydrogenase//N-ACETYLGLUTPREDUCT-RXN )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__469" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URACIL__45__PRIBOSYLTRANS__45__RXN" name="Uracil phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0212_upp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uracil phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOPHOSPHORYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4393_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLTRANSFER__45__RXN" name="Amino-acid N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4580_argJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glutamate N-acetyltransferase/amino-acid acetyltransferase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__NUCLEOTID__45__RXN" name="5&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4353 ) or ( RHILE2172_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 5&apos;-NUCLEOTIDASE (SIGNAL PEPTIDE) PROTEIN (EC 3.1.3.5) ) or ( survival protein, protein damage control )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R313__45__RXN" name="Nitrile hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3463_nthB ) or ( p11RHILE0130 ) or ( RHILE3464_nthA ) or ( p11RHILE0129_nthA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative nitrile hydratase beta subunit ) or ( putative Low-molecular weight cobalt-containing nitrile hydratase subunit beta (EC 4.2.1.84) (L-nitrilase) (L-NHase) ) or ( nitrile hydratase alpha subunit ) or ( nitrile hydratase alpha subunit )</html:p>
<html:p>SUBSYSTEM: aldoxime degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__CYANOPYRIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ALPHA__45__ALANINE_TO_PYRUVATE_COF_RXN" name="L-ALPHA-ALANINE_TO_PYRUVATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__REDUCT__45__NADPH__45__RXN" name="Glutathione reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2877_gor )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione oxidoreductase, nucleotide-binding//GLUTATHIONE-REDUCT-NADPH-RXN )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions II</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__6__45__RXN" name="Undecaprenyl-phosphate galactosephosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4092 ) or ( p9RHILE0154 ) or ( RHILE4695 ) or ( RHILE4082 ) or ( p9RHILE0059 ) or ( RHILE4011 ) or ( RHILE1763 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycosyltransferase ) or ( putative glycosyltransferase (modular protein) ) or ( Exopolysaccharide production protein PSS ) or ( putative glycosyltransferase ) or ( putative UDP-galactose phosphate transferase (WeeH) (modular protein) ) or ( Exopolysaccharide production protein PSS ) or ( putative glycosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="CPD__45__191" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOLATE__45__REDUCTASE__45__RXN" name="Glycolate reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0152 ) or ( RHILE4425 ) or ( p12RHILE0248 ) or ( p10RHILE0425 ) or ( p11RHILE0174 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dehydrogenase ) or ( putative glycerate dehydrogenase ) or ( putative D-isomer specific 2-hydroxyacid dehydrogenase ) or ( putative glycerate dehydrogenase ) or ( Glyoxylate reductase (EC 1.1.1.26) (Glycolate reductase)//Glyoxylate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.26</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1715_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__LACTDEHYDROGFMN__45__RXN" name="lactate oxidation" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3824_lldD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-lactate dehydrogenase, FMN-linked )</html:p>
<html:p>SUBSYSTEM: L-lactaldehyde degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donors reaction list</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)-- electron donors reaction list</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPONTPRO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45____45__OXO__45__ACID__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4676 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine aminotransferase 3 (EC 2.6.1.11) (ACOAT 3) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__NAD__43____45__RXN" name="DNA ligase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1374 ) or ( RHILE3523_ligA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative DNA ligase ) or ( DNA ligase//DNA-LIGASE-(NAD(+))-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4353 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 5&apos;-NUCLEOTIDASE (SIGNAL PEPTIDE) PROTEIN (EC 3.1.3.5) )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYKIN__45__RXN" name="Diacylglycerol kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2965 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Diacylglycerol kinase (EC 2.7.1.107) (DAGK) (Diglyceride kinase) (DGK)//Diacylglycerol kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.107</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THF_TO_10__45__FORMYL__45__THF_COF_RXN" name="THF_TO_10-FORMYL-THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BTUR2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3019_btuR ) or ( RHILE4601 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)alamin and cobinamide ATP-dependent adenolsyltransferase//BTUR2-RXN//COBALADENOSYLTRANS-RXN ) or ( DUF80 )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="COBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__GENERIC__45__RXN" name="alcohol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0328 ) or ( p12RHILE0464 ) or ( p9RHILE0032_adhP ) or ( RHILE1990 ) or ( p10RHILE0115 ) or ( p10RHILE0129 ) or ( RHILE1407 ) or ( p9RHILE0106 ) or ( p10RHILE0148 ) or ( p12RHILE0555_adhC ) or (  ) or ( p12RHILE0636 ) or ( RHILE3574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alcohol dehydrogenase, propanol-preferring ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase, propanol-preferring//ALCOHOL-DEHYDROG-GENERIC-RXN//ALCOHOL-DEHYDROG-RXN ) or ( putative Zn-containing alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase ) or ( putative OXIDOREDUCTASE TRANSMEMBRANE PROTEIN ) or ( Alcohol dehydrogenase (EC 1.1.1.1)//Alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase class III ) or ( putative iron-containing alcohol dehydrogenase (fragment) ) or ( Alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__45__Or__45__Ketones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACID__45__PHOSPHATASE__45__RXN" name="Acid phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2027 ) or ( p11RHILE0237 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nonspecific acid phosphatase ) or ( Nonspecific acid phosphatase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISPH2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1080_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__99__46__28__45__RXN" name="Glucose--fructose oxidoreductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0294 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glucose--fructose oxidoreductase//Glucose--fructose oxidoreductase )</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.28</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4549_aldB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase B (lactaldehyde dehydrogenase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.4</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__OXOPROLINASE__45__ATP__45__HYDROLYSING__45__RXN" name="5-oxoprolinase (ATP-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0436 ) or ( RHILE2603 ) or ( p12RHILE0435 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 5-oxoprolinase (ATP-hydrolyzing)//5-oxoprolinase (ATP-hydrolyzing) ) or ( 5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase) ) or ( putative 5-oxoprolinase (ATP-hydrolyzing)//5-oxoprolinase (ATP-hydrolyzing) )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__OXOPROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARTRANSFORM__45__RXN" name="Phosphoribosylaminoimidazolecarboxamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5017_purH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal)//AICARTRANSFORM-RXN//IMPCYCLOHYDROLASE-RXN//IMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.3</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AICAR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLACYLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1964 ) or ( p12RHILE0535_hcaA ) or ( RHILE1778 ) or ( RHILE1933_dcaE ) or ( RHILE0394_paaF ) or ( RHILE0641 ) or ( p12RHILE0178 ) or ( p12RHILE0072_paaF ) or ( RHILE1017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Enoyl-CoA hydratase//Enoyl-CoA hydratase ) or ( enoyl-CoA hydratase/lyase ) or ( putative enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase protein (EC 4.2.1.17) ) or ( putative dihydroxynaphthoic acid synthetase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DXPREDISOM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4663_dxr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose 5-phosphate reductoisomerase//DXPREDISOM-RXN )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.267</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2903 ) or ( RHILE4279_tktA ) or ( p10RHILE0490_tktB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative transketolase N-terminal section (EC 2.2.1.1) (TK) ) or ( transketolase 1 thiamin-binding, isozyme//1TRANSKETO-RXN//2TRANSKETO-RXN ) or ( transketolase 2, thiamin-binding, isozyme//1TRANSKETO-RXN//2TRANSKETO-RXN )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__148__45__RXN" name="4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0986_ispE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative isopentenyl monophosphate kinase//2.7.1.148-RXN )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.148</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LUMAZINESYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1729_ribE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( riboflavin synthase, beta chain )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__BUTANONE__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BAIAEUBSP__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0518 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-alpha-hydroxysteroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXO__45__CHOLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Pyridoxal kinase//Pyridoxal kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__59__45__RXN" name="L-lysine 6-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0330 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative hydroxylase )</html:p>
<html:p>SUBSYSTEM: aerobactin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.59</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__265" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRROLINEDEH__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0585_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: transcriptional repressor of proline utilization; proline dehydrogenase; pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1868 ) or ( RHILE3534 ) or ( RHILE0855 ) or ( p12RHILE0129 ) or ( RHILE4953_galE ) or ( RHILE0858 ) or ( RHILE4275 ) or ( RHILE0081 ) or ( p9RHILE0162 ) or ( p12RHILE0234 ) or ( RHILE4249 ) or ( p12RHILE0816 ) or ( RHILE0592_galE ) or ( p12RHILE0109 ) or ( p9RHILE0060 ) or ( RHILE0639_galE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative OXIDOREDUCTASE PROTEIN ) or ( UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase)//UDP-glucose 4-epimerase ) or ( putative dTDP-glucose-4,6-dehydratase/UDP-glucose 4-epimerase (WeeK) (WbpM)//UDP-glucose 4-epimerase ) or ( putative Thymidine diphosphoglucose 4,6-dehydratase ) or ( UDP-galactose 4-epimerase//UDPGLUCEPIM-RXN ) or ( putative UDP-glucose-4-epimerase ( dtdp-glucose 4,6- dehydratase) ) or ( putative OXIDOREDUCTASE PROTEIN ) or ( UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase)//UDP-glucose 4-epimerase ) or ( NAD dependent epimerase/dehydratase family protein ) or ( putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( SqdC (SULFOLIPID BIOSYNTHESIS PROTEIN) ) or ( putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( UDP-galactose 4-epimerase//UDPGLUCEPIM-RXN ) or ( putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( putative dTDP-glucose-4,6-dehydratase/UDP-glucose 4-epimerase (WeeK) (WbpM)//UDP-glucose 4-epimerase ) or ( UDP-galactose 4-epimerase//UDPGLUCEPIM-RXN )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__64__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2896 ) or ( RHILE1210 ) or ( RHILE3126 ) or ( RHILE1751 ) or ( RHILE4569_ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative methyl-transferase, S-Adenosyl-L-methionine (SAM)-MTase protein ) or ( putative methyltransferase ) or ( putative 3-demethylubiquinone-9 3-O-methyltransferase//3-demethylubiquinone-9 3-O-methyltransferase ) or ( Methyltransferase domain protein (modular protein) ) or ( bifunctional: 3-demethylubiquinone-9 3-methyltransferase; 2-octaprenyl-6-hydroxy phenol methylase//DHHB-METHYLTRANSFER-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LTAA__45__RXN" name="L-allo-threonine aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1715_glyA ) or ( RHILE4364 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) or ( Low-specificity L-threonine aldolase (EC 4.1.2.5) (Low-specificity L- TA) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALLO__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKAPHOSPHA__45__RXN" name="Alkaline phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5009 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Alkaline phosphatase (EC 3.1.3.1)//Alkaline phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__6__45__OHPHENOL__45__METHY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4569_ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: 3-demethylubiquinone-9 3-methyltransferase; 2-octaprenyl-6-hydroxy phenol methylase//DHHB-METHYLTRANSFER-RXN )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__METHOXYPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOBUTFORMLY__45__RXN" name="formate C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4816_yfgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative pyruvate formate lyase activating enzyme 2 )</html:p>
<html:p>SUBSYSTEM: threonine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONOLACT__45__RXN" name="6-phosphogluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0792 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase (EC 3.1.1.31) (6PGL)//6-phosphogluconolactonase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRNA__45__PSEUDOURIDINE__45__SYNTHASE__45__I__45__RXN" name="tRNA-pseudouridine synthase I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0128_truB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA pseudouridine 5S synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8538" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8537" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_ADP_COF_RXN" name="ATP_TO_ADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCISOM__45__RXN" name="Glucose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0533_pgi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosephosphate isomerase//PGLUCISOM-RXN )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THI__45__P__45__SYN__45__RXN" name="Thiamine-phosphate pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0479 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thiamine-phosphate pyrophosphorylase (EC 2.5.1.3) (TMP pyrophosphorylase) (TMP-PPase) (Thiamine-phosphate synthase) )</html:p>
<html:p>SUBSYSTEM: thiamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.3</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THZ__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8748" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5009 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Alkaline phosphatase (EC 3.1.3.1)//Alkaline phosphatase )</html:p>
<html:p>SUBSYSTEM: diethylphosphate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ETOH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8978" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTKIN__45__RXN" name="Glutamate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4977_proB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamate kinase//GLUTKIN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYKI__45__RXN" name="Thymidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3773_tdk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine kinase//DURIDKI-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITSYN__45__RXN" name="Citrate (si)-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2671 ) or ( RHILE2670 ) or ( RHILE2369_gltA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Citrate synthase ) or ( Citrate synthase ) or ( citrate synthase//CITSYN-RXN )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2103" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0726 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative polygalacturonase (EC 3.2.1.15) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__galacturonosyl__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__galacturonosyl__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8743" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0233 ) or ( RHILE3340 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Aryldialkylphosphatase//Aryldialkylphosphatase ) or ( putative Aryldialkylphosphatase//Aryldialkylphosphatase )</html:p>
<html:p>SUBSYSTEM: methyl parathion degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8973" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8974" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8746" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0233 ) or ( RHILE3340 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Aryldialkylphosphatase//Aryldialkylphosphatase ) or ( putative Aryldialkylphosphatase//Aryldialkylphosphatase )</html:p>
<html:p>SUBSYSTEM: paraoxon degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARAOXON" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
      <speciesReference species="DIETHYLPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPIDADISACCHARIDESYNTH__45__RXN" name="Lipid-A-disaccharide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2368_lpxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tetraacyldisaccharide-1-P synthase//LIPIDADISACCHARIDESYNTH-RXN )</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.182</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BISOHMYR__45__GLUCOSAMINYL__45__1P" stoichiometry="1"/>
      <speciesReference species="OH__45__MYRISTOYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BISOHMYR__45__GLC" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHHB__45__METHYLTRANSFER__45__RXN" name="3-demethylubiquinone-9 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2896 ) or ( RHILE1210 ) or ( RHILE3126 ) or ( RHILE1751 ) or ( RHILE4569_ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative methyl-transferase, S-Adenosyl-L-methionine (SAM)-MTase protein ) or ( putative methyltransferase ) or ( putative 3-demethylubiquinone-9 3-O-methyltransferase//3-demethylubiquinone-9 3-O-methyltransferase ) or ( Methyltransferase domain protein (modular protein) ) or ( bifunctional: 3-demethylubiquinone-9 3-methyltransferase; 2-octaprenyl-6-hydroxy phenol methylase//DHHB-METHYLTRANSFER-RXN )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__OH__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4OH2OXOGLUTARALDOL__45__RXN" name="4-hydroxy-2-oxoglutarate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4444_eda )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase//KDPGALDOL-RXN//OXALODECARB-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__4__45__HYDROXY__45__2__45__KETO__45__GLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYGLUCONOKIN__45__RXN" name="2-dehydro-3-deoxygluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3791 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-dehydro-3-deoxygluconokinase//2-dehydro-3-deoxygluconokinase )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>SUBSYSTEM: D-galacturonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.45</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBITOL__45__2__45__DEHYDROGENASE__45__RXN" name="ribitol 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0501 ) or ( RHILE0682 ) or ( p9RHILE0125 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ribitol 2-dehydrogenase (EC 1.1.1.56) (RDH)//Ribitol 2-dehydrogenase ) or ( Ribitol 2-dehydrogenase (EC 1.1.1.56) (RDH)//Ribitol 2-dehydrogenase ) or ( Ribitol 2-dehydrogenase (EC 1.1.1.56) (RDH)//Ribitol 2-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: ribitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.56</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__20__45__RXN" name="Methylenetetrahydrofolate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3561_metF ) or ( p9RHILE0267 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5,10-methylenetetrahydrofolate reductase//Deleted entry ) or ( putative 5,10-methylenetetrahydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.20</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPMANDEHYDRA__45__RXN" name="GDP-mannose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0870_gmd ) or ( p9RHILE0142_gmd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-D-mannose dehydratase, NAD(P)-binding, colanic acid synthesis//GDPMANDEHYDRA-RXN ) or ( GDP-D-mannose dehydratase, NAD(P)-binding, colanic acid synthesis//GDPMANDEHYDRA-RXN )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-&amp;alpha;-D-perosamine biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-6-deoxy-D-talose biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-D-rhamnose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.47</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTEPADENYLYLTRAN__45__RXN" name="Pantetheine-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2554_coaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CMP-deoxy-D-manno-octulosonate-lipid A transferase (phosphopantetheine adenylyltransferase)//PANTEPADENYLYLTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.3</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__SULFATASE__45__RXN" name="Choline-sulfatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0466 ) or ( RHILE4952 ) or ( p9RHILE0243 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Choline-sulfatase (EC 3.1.6.6)//Choline-sulfatase ) or ( Phosphonate monoester hydrolase ) or ( Phosphonate monoester hydrolase )</html:p>
<html:p>SUBSYSTEM: choline-O-sulfate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.6</html:p>
<html:p>SIDE: SULFATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__543" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__33__45__RXN" name="Glucose-1-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0260_rfbF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-D-glucose-1-phosphate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.33</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DECAPCISTRANSFER__45__RXN" name="di-trans-poly-cis-decaprenylcistransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2360_ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)//RXN0-5180 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="T__45__POLY__45__C__45__DECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="T__45__POLY__45__C__45__UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__23__45__DIOXYGENASE__45__RXN" name="Catechol 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3043 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Metapyrocatechase (EC 1.13.11.2) )</html:p>
<html:p>SUBSYSTEM: catechol degradation to 2-oxopent-4-enoate II</html:p>
<html:p>SUBSYSTEM: catechol degradation to 2-oxopent-4-enoate I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.2</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMUCONATE__45__SALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRIC__45__OXIDE__45__SYNTHASE__45__RXN" name="Nitric-oxide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2415 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Oxidoreductase, FAD-binding )</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.39</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NITRIC__45__OXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRIC__45__OXIDE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__AMINOADIPATE__45__AMINOTRANSFERASE__45__RXN" name="2-aminoadipate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3422 ) or ( RHILE1509 ) or ( p12RHILE0048 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-aminoadipate transaminase//2-aminoadipate transaminase ) or ( putative HTH-type transcriptional regulator in rdxA 3&apos;region ) or ( putative 2-aminoadipate transaminase//2-aminoadipate transaminase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.39</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GALACTOSE_TO_UDP_COF_RXN" name="UDP-GALACTOSE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXINE__45__4__45__DEHYDROGENASE__45__RXN" name="Pyridoxine 4-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0288 ) or ( RHILE3651 ) or ( RHILE0321 ) or ( RHILE3274 ) or ( RHILE2919 ) or ( RHILE2505 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo/keto reductase ) or ( putative Pyridoxine 4-dehydrogenase//Pyridoxine 4-dehydrogenase ) or ( putative Pyridoxine 4-dehydrogenase//Pyridoxine 4-dehydrogenase ) or ( putative Pyridoxine 4-dehydrogenase//Pyridoxine 4-dehydrogenase ) or ( putative Pyridoxine 4-dehydrogenase//Pyridoxine 4-dehydrogenase ) or ( putative Pyridoxine 4-dehydrogenase//Pyridoxine 4-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.65</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTACETYLTRAN__45__RXN" name="Maltose O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3897 ) or ( RHILE0267_maa ) or ( p12RHILE0571 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acetyltransferase PssR ) or ( maltose o-acetyltransferase ) or ( putative Maltose O-acetyltransferase//Maltose O-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.79</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLMALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R122__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0370 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hydroxydechloroatrazine ethylaminohydrolase (EC 3.5.99.3) (Hydroxyatrazine hydrolase)//Hydroxydechloroatrazine ethylaminohydrolase )</html:p>
<html:p>SUBSYSTEM: atrazine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ETHANAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYATRAZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANAMINE" stoichiometry="1"/>
      <speciesReference species="N__45__ISOPROPYLAMMELIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOLINATE__45__SYNTHA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0666_nadA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinolinate synthetase A )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: DIHYDROXY__45__ACETONE__45__PHOSPHATE</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="IMINOASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIP__45__KIN__45__RXN" name="Nucleoside-diphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1673_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINAMID__45__RXN" name="Nicotinamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3508_pncA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinamidase/pyrazinamidase//NICOTINAMID-RXN )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__68__45__RXN" name="2-deoxyglucose-6-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2108 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hydrolase, haloacid dehalogenase-like family )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.68</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEOXY__45__D__45__GLUCOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEOXY__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7226" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4925_ispA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase (=farnesyldiphosphate synthase)//FPPSYN-RXN//GPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6645" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_ACETYL__45__COA_COF_RXN" name="CO-A_TO_ACETYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIOSEPISOMERIZATION__45__RXN" name="Triosephosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2675_tpiA ) or ( p12RHILE0215 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triosephosphate isomerase//TRIOSEPISOMERIZATION-RXN ) or ( Triosephosphate isomerase 2 (EC 5.3.1.1) (TIM 2) (Triose-phosphate isomerase 2)//Triose-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__AMINOLEVULINIC__45__ACID__45__SYNTHASE__45__RXN" name="5-aminolevulinic acid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0008_hemA ) or ( RHILE4670_hemA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-aminolevulinic acid synthase (ALAS) ) or ( 5-aminolevulinic acid synthase (ALAS) )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.37</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5226" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0550 ) or ( RHILE4783 ) or ( RHILE2165 ) or ( p11RHILE0476 ) or ( RHILE4504 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Beta-N-acetylhexosaminidase//Beta-N-acetylhexosaminidase ) or ( putative N-acetyl-beta-glucosaminidase (EC 3.2.1.52) ) or ( putative sugar hydrolase ) or ( putative sugar hydrolase ) or ( putative Beta-N-acetylhexosaminidase//Beta-N-acetylhexosaminidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.52</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__882" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5225" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3550 ) or ( RHILE1849 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative peptidoglycan binding domain 1:N-acetylmuramoyl-L-alanine amidase, family 2//N-acetylmuramoyl-L-alanine amidase ) or ( putative N-acetylmuramoyl-L-alanine amidase//N-acetylmuramoyl-L-alanine amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1080" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1082" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R341__45__RXN" name="Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3012_cobB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cobyrinic acid a,c-diamide synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__687" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__688" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__221" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3211 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative amino acid decarboxylase, Pyridoxal-dependent protein (EC 4.1.1.-) )</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopamine)</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8766" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0675_cobL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative precorrin 6y methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9044" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9048" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5228" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2840_ycjG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-Ala-D/L-Glu epimerase, a muconate lactonizing enzyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALA__45__GAMMA__45__D__45__GLU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__Ala__45__L__45__Glu" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8767" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0675_cobL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative precorrin 6y methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9048" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9045" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8764" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0675_cobL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative precorrin 6y methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9047" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9043" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8762" name="Precorrin-4 C11-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0674_cobM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 3 or 4 methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.133</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9042" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TIGLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1964 ) or ( p12RHILE0535_hcaA ) or ( RHILE1778 ) or ( RHILE1933_dcaE ) or ( RHILE0394_paaF ) or ( RHILE0641 ) or ( p12RHILE0178 ) or ( p12RHILE0072_paaF ) or ( RHILE1017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Enoyl-CoA hydratase//Enoyl-CoA hydratase ) or ( enoyl-CoA hydratase/lyase ) or ( putative enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase protein (EC 4.2.1.17) ) or ( putative dihydroxynaphthoic acid synthetase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8761" name="Precorrin-3B C17-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0677_cobJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin 3 methylase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.131</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9040" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9041" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROKAEMPFEROL__45__4__45__REDUCTASE__45__RXN" name="Dihydrokaempferol 4-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0322 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cinnamoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.219</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROKAEMPFEROL__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LEUCOPELARGONIDIN__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2NEOPTERINALDOL__45__RXN" name="Dihydroneopterin aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2827 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydroneopterin aldolase (EC 4.1.2.25) (DHNA)//Dihydroneopterin aldolase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.25</html:p>
<html:p>SIDE: GLYCOLALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__NEO__45__PTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
      <speciesReference species="GLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__CARBOXYMUCONOLACTONE__45__DECARBOXYLASE__45__RXN" name="4-carboxymuconolactone decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0091_pcaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-carboxymuconolactone decarboxylase (CMD) )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.44</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7737" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXOADIPATE__45__ENOL__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__80__45__RXN" name="N-acetylgalactosamine-6-phosphate deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4897 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25)//N-acetylglucosamine-6-phosphate deacetylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPAMIDOTRANS__45__RXN" name="Amidophosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1637_purF ) or ( p11RHILE0599 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidophosphoribosyltransferase (PRPP amidotransferase)//PRPPAMIDOTRANS-RXN ) or ( putative glutamine amidotransferase-like protein (GlxB) )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.14</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDP_TO_CTP_COF_RXN" name="CDP_TO_CTP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0175 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxidoreductase )</html:p>
<html:p>SUBSYSTEM: ethylene biosynthesis from methionine</html:p>
<html:p>PROTEIN_CLASS: 1.14.17.4</html:p>
<html:p>SIDE: L__45__DEHYDRO__45__ASCORBATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: HCN</html:p>
<html:p>SIDE: ASCORBATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__68" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCN" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
      <speciesReference species="ETHYLENE__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOSEPHOSPHO__45__RXN" name="Protein-N(PI)-phosphohistidine-sugar phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0448 ) or ( p11RHILE0412 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative NITROGEN REGULATORY IIA PROTEIN (EC 2.7.1.69) ) or ( Phosphotransferase enzyme IIA (EC 2.7.1.69) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__12__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4537 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ExsC protein ( 6-pyruvoyl tetrahydropterin synthase protein) (EC 4.2.3.12) )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.12</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5213" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0798_ydjG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxidoreductase with NAD(P)-binding domain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5216" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0367 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Alpha-mannosidase//Alpha-mannosidase )</html:p>
<html:p>SUBSYSTEM: 2-O-&amp;alpha;-mannosyl-D-glycerate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1063" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3244 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Copper methylamine oxidase precursor (EC 1.4.3.6) (MAOXII) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0363 ) or ( RHILE4450 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Beta-glucosidase (EC 3.2.1.21) (Gentiobiase) (Cellobiase) (Beta-D- glucoside glucohydrolase)//Beta-glucosidase ) or ( Beta-glucosidase (EC 3.2.1.21) (Gentiobiase) (Cellobiase) (Beta-D- glucoside glucohydrolase) (Amygdalase)//Beta-glucosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINAMARIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXY__45__2__45__METHYLPROPANENITRILE" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLISOM__45__RXN" name="Xylose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4458_xylA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-xylose isomerase//XYLISOM-RXN )</html:p>
<html:p>SUBSYSTEM: xylose degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8751" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0028_xdhA ) or ( RHILE3814_xdhA ) or ( RHILE3815_xdhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative xanthine dehydrogenase subunit, molybdemum cofactor-binding domain ) or ( xanthine dehydrogenase, small subunit ) or ( xanthine dehydrogenase, large subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8752" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0028_xdhA ) or ( RHILE3814_xdhA ) or ( RHILE3815_xdhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative xanthine dehydrogenase subunit, molybdemum cofactor-binding domain ) or ( xanthine dehydrogenase, small subunit ) or ( xanthine dehydrogenase, large subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8753" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0028_xdhA ) or ( RHILE3814_xdhA ) or ( RHILE3815_xdhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative xanthine dehydrogenase subunit, molybdemum cofactor-binding domain ) or ( xanthine dehydrogenase, small subunit ) or ( xanthine dehydrogenase, large subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9017" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p8RHILE0077 ) or ( p12RHILE0665_aldH ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1964 ) or ( p12RHILE0535_hcaA ) or ( RHILE1778 ) or ( RHILE1933_dcaE ) or ( RHILE0394_paaF ) or ( RHILE0641 ) or ( p12RHILE0178 ) or ( p12RHILE0072_paaF ) or ( RHILE1017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Enoyl-CoA hydratase//Enoyl-CoA hydratase ) or ( enoyl-CoA hydratase/lyase ) or ( putative enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase protein (EC 4.2.1.17) ) or ( putative dihydroxynaphthoic acid synthetase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8754" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0028_xdhA ) or ( RHILE3814_xdhA ) or ( RHILE3815_xdhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative xanthine dehydrogenase subunit, molybdemum cofactor-binding domain ) or ( xanthine dehydrogenase, small subunit ) or ( xanthine dehydrogenase, large subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9017" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QOR__45__RXN" name="NADPH:quinone reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0044 ) or ( RHILE1355 ) or ( RHILE3002 ) or ( p12RHILE0386 ) or ( RHILE2681 ) or ( RHILE0908 ) or ( RHILE3750 ) or ( p11RHILE0547 ) or ( p11RHILE0141 ) or ( RHILE3966 ) or ( RHILE1550 ) or ( RHILE2508 ) or ( RHILE1336_qor ) or ( RHILE2520_qor )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxidoreductase protein ) or ( putative NADPH quinone oxidoreductase ) or ( alcohol dehydrogenase ) or ( Quinone oxidoreductase (EC 1.6.5.5) ) or ( putative OXIDOREDUCTASE PROTEIN ) or ( Alcohol dehydrogenase, zinc-containing ) or ( putative quinone oxidoreductase ) or ( putative zinc-binding oxidoreductase ) or ( Alcohol dehydrogenase, zinc-containing ) or ( putative OXIDOREDUCTASE PROTEIN ) or ( putative alginate lyase ) or ( Alcohol dehydrogenase, zinc-containing ) or ( quinone oxidoreductase, NADPH-dependent//QOR-RXN ) or ( quinone oxidoreductase, NADPH-dependent//QOR-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Semiquinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_GLT_COF_RXN" name="2-KETOGLUTARATE_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCONDEHYDRAT__45__RXN" name="Phosphogluconate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0791_edd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydratase//PGLUCONDEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEPHOSPHORYLATION__45__RXN" name="5&apos;-nucleotidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4353 ) or ( RHILE2172_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 5&apos;-NUCLEOTIDASE (SIGNAL PEPTIDE) PROTEIN (EC 3.1.3.5) ) or ( survival protein, protein damage control )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PABASYN__45__RXN" name="Aminodeoxychorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4345 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative PARA-AMINOBENZOATE SYNTHASE COMPONENT I PROTEIN (EC 4.1.3.-) )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.8</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4385 ) or ( RHILE0583_argF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Ornithine carbamoyltransferase//Ornithine carbamoyltransferase ) or ( ornithine carbamoyltransferase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: CARBAMOYL__45__P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTERIDINEPYROPHOSPHOKIN__45__RXN" name="2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2826_folK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase//H2PTERIDINEPYROPHOSPHOKIN-RXN )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDPGALDOL__45__RXN" name="2-dehydro-3-deoxyphosphogluconate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4444_eda )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase//KDPGALDOL-RXN//OXALODECARB-RXN )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0193 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Amine oxidase (flavin-containing)//Amine oxidase (flavin-containing) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__30" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATREDUCT__45__RXN" name="Nitrate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2109_nasA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrate reductase, large subunit )</html:p>
<html:p>SUBSYSTEM: nitrate reduction I (denitrification)</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.4</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__90__45__RXN" name="Diphosphate--fructose-6-phosphate 1-phosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3552 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (EC 2.7.1.90) (6-phosphofructokinase, pyrophosphate dependent) (Pyrophosphate- dependent 6-phosphofructose-1-kinase) (PPi-dependent phosphofructokinase) (PPi-PFK) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.90</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__NH3__45__RXN" name="NAD(+) synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2871_nadE ) or ( RHILE1415_nadE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NH3-dependent NAD synthetase ) or ( NAD synthetase, prefers NH3 over glutamine//NAD-SYNTH-NH3-RXN )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__0" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2530_glmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal)//NAG1P-URIDYLTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2141" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3785 ) or ( RHILE0788 ) or ( p12RHILE0747 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alpha-glucosidase (EC 3.2.1.20) ) or ( putative alpha-glucosidase (EC 3.2.1.20) ) or ( putative ALPHA-AMYLASE-RELATED PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCC__45__FUM__45__OXRED__45__RXN" name="Succinate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4736_sdhA ) or ( RHILE4735_sdhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate dehydrogenase, catalytic and NAD/flavoprotein subunit ) or ( succinate dehydrogenase, Fe-S protein )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAPHTHALENE__45__12__45__DIOXYGENASE__45__RXN" name="Naphthalene 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0569 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Iron-sulphur Rieske protein )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAPHTHALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__12__45__DIHYDRONAPHTHALENE__45__12__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHAGALACTOSID__45__RXN" name="&amp;alpha;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( p11RHILE0259 ) or ( p12RHILE0265_melA ) or ( p11RHILE0264_melA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-galactosidase NAD(P)-binding (fragment) ) or ( Alpha-galactosidase (EC 3.2.1.22) (Melibiase)//Alpha-galactosidase ) or ( alpha-galactosidase NAD(P)-binding//ALPHAGALACTOSID-RXN ) or ( alpha-galactosidase NAD(P)-binding//ALPHAGALACTOSID-RXN )</html:p>
<html:p>SUBSYSTEM: melibiose degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MELIBIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETRAACYLDISACC4KIN__45__RXN" name="Tetraacyldisaccharide 4&apos;-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0954 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tetraacyldisaccharide 4&apos;-kinase (EC 2.7.1.130) (Lipid A 4&apos;-kinase)//Tetraacyldisaccharide 4&apos;-kinase )</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.130</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BISOHMYR__45__GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPID__45__IV__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALARACECAT__45__RXN" name="Alanine racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1641 ) or ( p12RHILE0440_dadX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alanine racemase ) or ( alanine racemase 2, PLP-binding, catabolic//ALARACECAT-RXN )</html:p>
<html:p>SUBSYSTEM: alanine degradation I</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1624_psd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphatidylserine decarboxylase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.65</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5063" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0416_miaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( involved in methylthiolation of isopentenylated A37 derivatives in tRNA, Fe-S protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__6__45__ISOPENTYL__45__ADENOSINE__45__37__45__TRNA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYLTHIO__45__N__45__6__45__ISOPENTYL__45__ADENOSINE__45__37__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CEREBROSIDE__45__SULFATASE__45__RXN" name="Cerebroside-sulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2406 ) or ( p11RHILE0238 ) or ( RHILE1308 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ArsA protein ) or ( putative arylsulfatase (EC 3.1.6.8) ) or ( putative arylsulfatase protein (EC 3.1.6.1) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSYLCERAMIDE__45__SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__45__GALACTOSYLCERAMIDE" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDUD__45__RXN" name="2-deoxy-D-gluconate 3-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0569_kduD ) or ( RHILE2907_kduD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-deoxy-D-gluconate 3-dehydrogenase ) or ( 2-deoxy-D-gluconate 3-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.125</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DE__45__O__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DE__45__O__45__K__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCGLU__45__SEMIALDEHYDE__45__SUCCGLU__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0585_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: transcriptional repressor of proline utilization; proline dehydrogenase; pyrroline-5-carboxylate dehydrogenase//PYRROLINECARBDEHYDROG-RXN//RXN-821 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__SUCCINYLGLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCOSEPP__45__RXN" name="Glucose-1-phosphate thymidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0839_rfbA ) or ( RHILE1719_rfbA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-glucose pyrophosphorylase ) or ( dTDP-glucose pyrophosphorylase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.24</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__26__45__RXN" name="&amp;beta;-fructofuranosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0590 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Beta-fructofuranosidase//Beta-fructofuranosidase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.26</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTASE__45__RXN" name="Aspartate ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate ammonia-lyase (aspartase) (fragment) )</html:p>
<html:p>SUBSYSTEM: glutamate degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARDIOLIPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0342 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cardiolipin synthase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>SIDE: GLYCEROL</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARDIOLIPIN" stoichiometry="1"/>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYMETHYLENEBUTENOLIDASE__45__RXN" name="Carboxymethylenebutenolidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0524 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dienelactone hydrolase family protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CARBOXYMETHYLENEBUT__45__2__45__EN__45__4__45__OLIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXOHEX__45__2__45__ENEDIOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__20__45__RXN" name="4-hydroxybenzoyl-CoA reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p8RHILE0027_hbaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybenzoyl-CoA reductase, first of three subunits )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.20</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__201" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMIDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0864 ) or ( RHILE0865 ) or ( RHILE0042_hisF ) or ( RHILE0046_hisH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative imidazole glycerol phosphate synthase subunit hisF2 (EC 4.1.3.-) (IGP synthase cyclase subunit) (IGP synthase subunit hisF2) (ImGP synthase subunit hisF2) (IGPS subunit hisF2) ) or ( Imidazole glycerol phosphate synthase subunit hisH2 (EC 2.4.2.-) (IGP synthase glutamine amidotransferase subunit) (IGP synthase subunit hisH2) (ImGP synthase subunit hisH2) (IGPS subunit hisH2) ) or ( imidazole glycerol phosphate synthase, subunit with HisH ) or ( glutamine amidotransferase, subunit with HisF )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2301" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4806 ) or ( p10RHILE0326_ivd2 ) or ( RHILE1847_aidB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acyl-CoA dehydrogenase ) or ( isovaleryl-CoA dehydrogenase ) or ( putative acyl-CoA dehydrogenase (flavoprotein) , adaptive response (transcription activated by Ada) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATEPRIBOSYLTRANS__45__RXN" name="Nicotinate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0197 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nicotinate phosphoribosyltransferase (EC 2.4.2.11) (NAPRTase)//Nicotinate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.11</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PURINE__45__NUCLEOSIDASE__45__RXN" name="Purine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4150 ) or ( RHILE3014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative inosine-uridine preferring nucleoside hydrolase protein ) or ( putative Purine nucleosidase//Purine nucleosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPICRED__45__RXN" name="Dihydrodipicolinate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0186_dapB ) or ( RHILE3206_dapB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrodipicolinate reductase ) or ( dihydrodipicolinate reductase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.26</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1673_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYRIBOSE__45__P__45__ALD__45__RXN" name="Deoxyribose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0209_deoC ) or ( RHILE2929 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-deoxyribose-5-phosphate aldolase, NAD(P)-linked//DEOXYRIBOSE-P-ALD-RXN ) or ( putative deoxyribose-phosphate aldolase (EC 4.1.2.4) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) (DERA) (CGI-26) )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTDEAM__45__RXN" name="Cytosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0324 ) or ( p9RHILE0219_codA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cytosine deaminase ) or ( cytosine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__141__45__RXN" name="4-&amp;alpha;-D-{(1->4)-&amp;alpha;-D-glucano}-trehalose trehalohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0761 ) or ( p12RHILE0747 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative maltooligosyltrehalose trehalohydrolase ) or ( putative ALPHA-AMYLASE-RELATED PROTEIN )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.141</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOOLIGOSYLTREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPIONYL__45__COA__45__CARBOXY__45__RXN" name="Propionyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2730_pccB ) or ( p10RHILE0325 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( propionyl-CoA carboxylase beta chain ) or ( putative acyl-CoA carboxylase, beta chain )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="Myo-inositol-1(or 4)-monophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4300_suhB ) or ( p9RHILE0275 ) or ( RHILE2797 ) or ( RHILE0949 ) or ( RHILE3347 ) or ( RHILE4369 ) or ( p9RHILE0228_suhB ) or ( RHILE2798 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol monophosphatase//MYO-INOSITOL-1(OR-4)-MONOPHOSPHATASE-RXN ) or ( putative inositol monophosphatase ) or ( putative Inositol-phosphate phosphatase//Inositol-phosphate phosphatase ) or ( putative myo-inositol monophosphatase 2 family protein ) or ( Inositol monophosphatase family protein ) or ( putative Mono-phosphatase ) or ( inositol-1-monophosphatase (IMPase) (Inositol-1- phosphatase) (I-1-Pase)//MYO-INOSITOL-1(OR-4)-MONOPHOSPHATASE-RXN ) or ( putative Inositol-phosphate phosphatase//Inositol-phosphate phosphatase )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALANINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Alanine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0265 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Alanine--glyoxylate transaminase//Alanine--glyoxylate transaminase )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.44</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETATEKIN__45__RXN" name="Acetate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2003 ) or ( RHILE4170 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetate kinase (EC 2.7.2.1) (Acetokinase)//Acetate kinase ) or ( Acetate kinase (EC 2.7.2.1) (Acetokinase)//Acetate kinase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate II</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTMPKI__45__RXN" name="Thymidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2632_tmk ) or ( RHILE1653_yceG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate kinase//DTMPKI-RXN ) or ( putative dTMP kinase//dTMP kinase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE__45__1__45__EPIMERASE__45__RXN" name="Aldose 1-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4900 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase)//Aldose 1-epimerase )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__ALANINE__45__AMINOTRANSFERASE__45__RXN" name="D-alanine aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2424 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-alanine aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5040" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0514_abgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative peptidase, p-aminobenzoyl-glutamate utilization, with Zn-dependent exopeptidase domain and carboxypeptidase G2, dimerisation domain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__889" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYMETVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0246 ) or ( RHILE4713_ilvD3 ) or ( RHILE1912_ilvD ) or ( RHILE4033_ilvD1 ) or ( RHILE3860 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Dihydroxy-acid dehydratase//Dihydroxy-acid dehydratase ) or ( dihydroxy-acid dehydratase ) or ( dihydroxyacid dehydratase//DIHYDROXYISOVALDEHYDRAT-RXN//DIHYDROXYMETVALDEHYDRAT-RXN ) or ( dihydroxy-acid dehydratase ) or ( putative dihydroxy-acid dehydratase protein (EC 4.2.1.9) )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8925" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2217 ) or ( p12RHILE0646 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aminotransferase ) or ( putative aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="an__32__amine__32__donor" stoichiometry="1"/>
      <speciesReference species="VANILLIN" stoichiometry="1"/>
      <speciesReference species="__124__Amineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="deaminated__32__donor" stoichiometry="1"/>
      <speciesReference species="CPD__45__9327" stoichiometry="1"/>
      <speciesReference species="__124__Deamineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__10__46__1__45__RXN" name="Receptor protein-tyrosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4084 ) or ( p9RHILE0001 ) or ( p7RHILE0001 ) or ( RHILE3915 ) or ( p9RHILE0143 ) or ( p7RHILE0089 ) or ( RHILE5032_parA ) or ( p8RHILE0001 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Protein-tyrosine kinase ) or ( putative replication protein A ) or ( putative replication protein A ) or ( Succinoglycan biosynthesis transport protein exoP ) or ( putative Protein-tyrosine kinase ) or ( putative replication protein A ) or ( chromosome partitioning protein, ParA ) or ( putative replication protein A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.10.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINLYA__45__RXN" name="Argininosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4607_argH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3902" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0423 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MUCONATE__45__CYCLOISOMERASE__45__RXN" name="Muconate cycloisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4115 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Galactonate dehydratase )</html:p>
<html:p>SUBSYSTEM: catechol degradation to &amp;beta;-ketoadipate</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__CIS__45__MUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__741" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPNACETYLGLUCOSAMENOLPYRTRANS__45__RXN" name="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0648_murA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine 1-carboxyvinyltransferase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.7</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_ACYL__45__COA_COF_RXN" name="CO-A_TO_ACYL-COA_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__272__45__RXN" name="(R)-2-hydroxyacid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0635 ) or ( p12RHILE0544 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ) or ( putative (R)-2-hydroxyacid dehydrogenase//(R)-2-hydroxyacid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.272</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__367" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__380" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6841" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0082_glpD ) or ( p12RHILE0211_glpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sn-glycerol-3-phosphate dehydrogenase FAD/NAD(P)-binding (aerobic)//GLYC3PDEHYDROG-RXN//RXN0-5258 ) or ( sn-glycerol-3-phosphate dehydrogenase FAD/NAD(P)-binding (aerobic)//GLYC3PDEHYDROG-RXN//RXN0-5258 )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NACGLCTRANS__45__RXN" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3537_murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine:N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase//NACGLCTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C5" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1964 ) or ( p12RHILE0535_hcaA ) or ( RHILE1778 ) or ( RHILE1933_dcaE ) or ( RHILE0394_paaF ) or ( RHILE0641 ) or ( p12RHILE0178 ) or ( p12RHILE0072_paaF ) or ( RHILE1017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Enoyl-CoA hydratase//Enoyl-CoA hydratase ) or ( enoyl-CoA hydratase/lyase ) or ( putative enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase protein (EC 4.2.1.17) ) or ( putative dihydroxynaphthoic acid synthetase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMEOSYN__45__RXN" name="heme o biosynthesis" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1073_cyoE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoheme IX farnesyltransferase (heme O biosynthesis) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEME_O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCDEHYDROG__45__RXN" name="Phosphoglycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4232_serA2 ) or ( p9RHILE0185 ) or ( p9RHILE0285 ) or ( RHILE0195 ) or ( p12RHILE0621 ) or ( p10RHILE0311 ) or ( RHILE0088 ) or ( p12RHILE0667 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoglycerate dehydrogenase ) or ( Phosphoglycerate dehydrogenase (modular protein)//Phosphoglycerate dehydrogenase ) or ( putative OXIDOREDUCTASE PROTEIN ) or ( putative HYDROXYACID DEHYDROGENASE PROTEIN (EC 1.1.1.-) ) or ( putative ) or ( putative dehydrogenase protein ) or ( putative dehydrogenase protein ) or ( D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) )</html:p>
<html:p>SUBSYSTEM: superpathway of cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.95</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTCYSLIG__45__RXN" name="Glutamate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0902_gshA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamylcysteine synthetase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNTRANSAM__45__RXN" name="Acetylornithine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4676 ) or ( RHILE0582_argD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine aminotransferase 3 (EC 2.6.1.11) (ACOAT 3) ) or ( acetylornithine transaminase (NAcOATase and DapATase), PLP-dependent//ACETYLORNTRANSAM-RXN//SUCCINYLDIAMINOPIMTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.11</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__469" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8172" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__6__45__AMINO__45__CAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREOSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>SUBSYSTEM: aminopropanol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMPSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2773_purB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase//AICARSYN-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8173" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7682" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENIIISYN__45__RXN" name="uroporphyrinogen-III synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4790 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative UROPORPHYRINOGEN-III SYNTHASE PROTEIN (EC 4.2.1.75) )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.75</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__2__45__DEHYDROGENASE__45__RXN" name="Myo-inositol 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4712 ) or ( p9RHILE0308 ) or ( p12RHILE0031 ) or ( RHILE2978 ) or ( p11RHILE0083 ) or ( RHILE0097 ) or ( RHILE3872 ) or ( p9RHILE0294 ) or ( RHILE1588 ) or ( p12RHILE0412 ) or ( RHILE0089 ) or ( p12RHILE0024 ) or ( p11RHILE0525 ) or ( RHILE0869 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative NADH-dependent dyhydrogenase ) or ( putative OXIDOREDUCTASE PROTEIN ) or ( putative OXIDOREDUCTASE PROTEIN ) or ( putative Inositol 2-dehydrogenase//Inositol 2-dehydrogenase ) or ( putative Inositol 2-dehydrogenase//Inositol 2-dehydrogenase ) or ( putative OXIDOREDUCTASE PROTEIN ) or ( Inositol 2-dehydrogenase (EC 1.1.1.18)//Inositol 2-dehydrogenase ) or ( putative Inositol 2-dehydrogenase//Inositol 2-dehydrogenase ) or ( putative Inositol 2-dehydrogenase//Inositol 2-dehydrogenase ) or ( putative Inositol 2-dehydrogenase//Inositol 2-dehydrogenase ) or ( putative OXIDOREDUCTASE PROTEIN ) or ( Dehydrogenase ) or ( putative oxidoreductase protein ) or ( Putative oxidoreductase (modular protein) )</html:p>
<html:p>SUBSYSTEM: myo-inositol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.18</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__365" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__905" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0330 ) or ( RHILE0629 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-hydroxyacyl-CoA dehydrogenase//3-hydroxyacyl-CoA dehydrogenase ) or ( putative 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoyl-CoA (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBOXYMETHYL__45__HYDROXYPHENYLPROPCOA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYLSUCCINYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__CYCLODEAMINASE__45__RXN" name="Ornithine cyclodeaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0789 ) or ( RHILE4751 ) or ( RHILE3207 ) or ( RHILE3308 ) or ( p12RHILE0055 ) or ( RHILE0060 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ornithine cyclodeaminase ) or ( putative ornithine cyclodeaminase (EC 4.3.1.12) ) or ( putative Ornithine cyclodeaminase, (EC 4.3.1.12)//Ornithine cyclodeaminase ) or ( Ornithine cyclodeaminase (EC 4.3.1.12) (OCD)//Ornithine cyclodeaminase ) or ( Ornithine cyclodeaminase 1 (EC 4.3.1.12) (OCD 1)//Ornithine cyclodeaminase ) or ( Ornithine cyclodeaminase; Ocd2//Ornithine cyclodeaminase )</html:p>
<html:p>SUBSYSTEM: ornithine degradation (proline biosynthesis)</html:p>
<html:p>SUBSYSTEM: arginine degradation VII (arginase 3 pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBINPGUANYLYLTRANS__45__RXN" name="Adenosylcobinamide-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3022_cobU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional cobinamide kinase, cobinamide phosphate guanylyltransferase protein//COBINPGUANYLYLTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.62</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETHYDPICSUCC__45__RXN" name="2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0460_dapD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase//TETHYDPICSUCC-RXN )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.117</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__SUCCINYL__45__2__45__AMINO__45__6__45__KETOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATEREDUCT__45__RXN" name="Dihydrofolate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3483_folA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrofolate reductase type I, trimethoprim resistance//DIHYDROFOLATEREDUCT-RXN )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCTP__45__DEAM__45__RXN" name="dCTP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0588 ) or ( RHILE0552 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dCTP deaminase//dCTP deaminase ) or ( putative cytidine and deoxycytidylate deaminase zinc-binding protein )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.13</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBUTYRYL__45__COA__45__DEHYDROGENASE__45__RXN" name="3-hydroxybutyryl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4605_hbdA ) or ( p10RHILE0410 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydrogenase ) or ( putative HYDROXYACYL-COA DEHYDROGENASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.157</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__3__45__HYDROXYBUTANOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7693" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0328 ) or ( p12RHILE0464 ) or ( p9RHILE0032_adhP ) or ( RHILE1990 ) or ( p10RHILE0115 ) or ( p10RHILE0129 ) or ( RHILE1407 ) or ( p9RHILE0106 ) or ( p10RHILE0148 ) or ( p12RHILE0555_adhC ) or (  ) or ( p12RHILE0636 ) or ( RHILE3574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alcohol dehydrogenase, propanol-preferring ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase, propanol-preferring//ALCOHOL-DEHYDROG-GENERIC-RXN//ALCOHOL-DEHYDROG-RXN ) or ( putative Zn-containing alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase ) or ( putative OXIDOREDUCTASE TRANSMEMBRANE PROTEIN ) or ( Alcohol dehydrogenase (EC 1.1.1.1)//Alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase class III ) or ( putative iron-containing alcohol dehydrogenase (fragment) ) or ( Alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7031" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7032" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNDEAM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1717 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative RIBOFLAVIN BIOSYNTHESIS PROTEIN (Riboflavin-specific deaminase/reductase) (EC 3.5.4.26) (EC 1.1.1.193) )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.26</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__17__45__RXN" name="Calcium/calmodulin-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0490 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ImpN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7694" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0328 ) or ( p12RHILE0464 ) or ( p9RHILE0032_adhP ) or ( RHILE1990 ) or ( p10RHILE0115 ) or ( p10RHILE0129 ) or ( RHILE1407 ) or ( p9RHILE0106 ) or ( p10RHILE0148 ) or ( p12RHILE0555_adhC ) or (  ) or ( p12RHILE0636 ) or ( RHILE3574 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alcohol dehydrogenase, propanol-preferring ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase, propanol-preferring//ALCOHOL-DEHYDROG-GENERIC-RXN//ALCOHOL-DEHYDROG-RXN ) or ( putative Zn-containing alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase ) or ( putative OXIDOREDUCTASE TRANSMEMBRANE PROTEIN ) or ( Alcohol dehydrogenase (EC 1.1.1.1)//Alcohol dehydrogenase ) or ( putative iron-containing alcohol dehydrogenase ) or ( alcohol dehydrogenase class III ) or ( putative iron-containing alcohol dehydrogenase (fragment) ) or ( Alcohol dehydrogenase ) or ( putative Alcohol dehydrogenase//Alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLBUT__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7033" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM__45__RXN" name="Cytidine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0207 ) or ( RHILE0552 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) (CDA)//Cytidine deaminase ) or ( putative cytidine and deoxycytidylate deaminase zinc-binding protein )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9023" name="disproportionating enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0762 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 4-alpha-glucanotransferase//4-alpha-glucanotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Truncated__45__Limit__45__Dextrins__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCDEHYDRAT__45__RXN" name="dTDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3879 ) or ( RHILE1721_rffG ) or ( RHILE0593 ) or (  ) or ( p9RHILE0155 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DTDP-glucose 4-6-dehydratase ) or ( dTDP-glucose 4,6-dehydratase ) or ( putative sugar nucleotide dehydratase ) or ( putative sugar nucleotide dehydratase (fragment) ) or ( putative sugar nucleotide dehydratase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.46</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9025" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4393_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAHPSYN__45__RXN" name="2-dehydro-3-deoxyphosphoheptonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2869_aroG ) or ( RHILE2875_aroG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase, phenylalanine-repressible)//DAHPSYN-RXN ) or ( 2-dehydro-3-deoxyphosphoheptonate aldolase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.54</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="adenylosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4028_purA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate synthetase//ADENYLOSUCCINATE-SYNTHASE-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.4</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMACTRANS__45__RXN" name="Diamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2530_glmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal)//NAG1P-URIDYLTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aliphatic__45__N__45__Acetyl__45__Diamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOGLUCMUT__45__RXN" name="Phosphoglucomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4397 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoglucomutase (EC 5.4.2.2) (Glucose phosphomutase) (PGM)//Phosphoglucomutase )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0533_pgi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosephosphate isomerase//PGLUCISOM-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEH__45__RXN" name="Malate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4731_mdh ) or ( p12RHILE0239 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate dehydrogenase, NAD(P)-binding//MALATE-DEH-RXN ) or ( putative malate/L-lactate dehydrogenase (EC 1.1.1.27) )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: aspartate degradation II</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.37</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__7" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3113 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative O-methyltransferase (EC 2.1.1.6) )</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.6</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__5" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p8RHILE0077 ) or ( p12RHILE0665_aldH ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__6" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3113 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative O-methyltransferase (EC 2.1.1.6) )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.6</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7651" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__2__46__20__45__RXN" name="2-dehydro-3-deoxyglucarate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0469 ) or (  ) or ( p11RHILE0166 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase ) or ( putative 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, with PEP/pyruvate domain (fragment) ) or ( putative aldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__D__45__GLUCARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNPOXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1064_pdxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine 5&apos;-phosphate oxidase//PMPOXI-RXN//PNPOXI-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__O__45__METHYLTRANSFERASE__45__RXN" name="Catechol O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3113 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative O-methyltransferase (EC 2.1.1.6) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.6</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__400" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNCOARACE__45__RXN" name="carnitine racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0026_caiD ) or ( p10RHILE0413_caiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitinyl-CoA dehydratase (Crotonobetainyl-CoA hydratase) ) or ( crotonobetainyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.-.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__CARNITINYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CARNITINYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONATE__45__5__45__DEHYDROGENASE__45__RXN" name="Gluconate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3025 ) or ( p11RHILE0087_idnO ) or ( p10RHILE0426_idnO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gluconate 5-dehydrogenase (EC 1.1.1.69) (5-keto-D-gluconate 5- reductase)//Gluconate 5-dehydrogenase ) or ( 5-keto-D-gluconate-5-reductase//GLUCONATE-5-DEHYDROGENASE-RXN ) or ( 5-keto-D-gluconate-5-reductase//GLUCONATE-5-DEHYDROGENASE-RXN )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>SUBSYSTEM: L-idonate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.69</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__DEHYDROGLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__4" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0193 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Amine oxidase (flavin-containing)//Amine oxidase (flavin-containing) )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTP_TO_CMP_COF_RXN" name="CTP_TO_CMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0266 ) or ( RHILE0046_hisH ) or ( RHILE2124 ) or ( RHILE0333_guaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative GMP synthase (glutamine-hydrolyzing)//GMP synthase (glutamine-hydrolyzing) ) or ( glutamine amidotransferase, subunit with HisF ) or ( putative glutamine amidotransferase ) or ( GMP synthetase (glutamine aminotransferase)//GMP-SYN-GLUT-RXN//GMP-SYN-NH3-RXN//GMP synthase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.2</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2201_GatA2 ) or ( p9RHILE0215 ) or ( p11RHILE0464 ) or ( RHILE0232 ) or ( p12RHILE0140 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glu-tRNA(Gln) amidotransferase subunit A ) or ( putative amidase ) or ( Glutamyl-tRNA amidotransferase subunit A ) or ( putative amidase ) or ( putative AMIDASE PROTEIN )</html:p>
<html:p>SUBSYSTEM: anandamide degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7598" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOATE__45__BETA__45__ALANINE__45__LIG__45__RXN" name="Pantoate--&amp;beta;-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0379_panC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantothenate synthetase//PANTOATE-BETA-ALANINE-LIG-RXN )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FPPSYN__45__RXN" name="geranyltranstransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4925_ispA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase (=farnesyldiphosphate synthase)//FPPSYN-RXN//GPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: geranylgeranyldiphosphate biosynthesis II (plastidic)</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NADP__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0430_maeB ) or ( RHILE2851_maeB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative bifunctional: malic oxidoreductase (N-terminal); phosphotransacetylase (C-terminal) ) or ( putative bifunctional: malic oxidoreductase (N-terminal); phosphotransacetylase (C-terminal) )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.40</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCIT__45__CLEAV__45__RXN" name="Isocitrate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0803_aceA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate lyase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYPHENYLPYRUVATE__45__DIOXYGENASE__45__RXN" name="4-hydroxyphenylpyruvate dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3037 ) or ( RHILE1975_hpd ) or ( p11RHILE0077 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 4-hydroxyphenylpyruvate dioxygenase protein (EC 1.13.11.27)//4-hydroxyphenylpyruvate dioxygenase ) or ( 4-hydroxyphenylpyruvate dioxygenase ) or ( putative 4-hydroxyphenylpyruvate dioxygenase//4-hydroxyphenylpyruvate dioxygenase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.27</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1__45__42" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2219_phbC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( poly-beta-hydroxybutyrate synthase )</html:p>
<html:p>SUBSYSTEM: polyhydroxybutyrate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CPD__45__650</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
      <speciesReference species="PHB" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHB" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBINAMIDEKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3022_cobU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional cobinamide kinase, cobinamide phosphate guanylyltransferase protein//COBINPGUANYLYLTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.156</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTOLDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0650_hisD ) or ( p8RHILE0046 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional HisD: L-histidinal:NAD+ dehydrogenase ; L-histidinol:NAD+ dehydrogenase//HISTALDEHYD-RXN//HISTOLDEHYD-RXN ) or ( Histidinol dehydrogenase 2 (EC 1.1.1.23) (HDH 2)//Histidinol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R9__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1964 ) or ( p12RHILE0535_hcaA ) or ( RHILE1778 ) or ( RHILE1933_dcaE ) or ( RHILE0394_paaF ) or ( RHILE0641 ) or ( p12RHILE0178 ) or ( p12RHILE0072_paaF ) or ( RHILE1017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Enoyl-CoA hydratase//Enoyl-CoA hydratase ) or ( enoyl-CoA hydratase/lyase ) or ( putative enoyl-CoA hydratase ) or ( enoyl-CoA hydratase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase protein (EC 4.2.1.17) ) or ( putative dihydroxynaphthoic acid synthetase ) or ( enoyl-CoA hydratase-isomerase, phenylacetic acid degradation (strain W) ) or ( putative enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0024_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: folylpolyglutamate synthase; dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD_TO_NADH_COF_RXN" name="NAD_TO_NADH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROGBIOSYN__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4787_gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase (NAD+)//GLYC3PDEHYDROGBIOSYN-RXN )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.94</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FMNH2_TO_FMN_COF_RXN" name="FMNH2_TO_FMN_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FMNH2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHENYLTHFCYCLOHYDRO__45__RXN" name="Methenyltetrahydrofolate cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0783_folD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; 5,10-methylene-tetrahydrofolate cyclohydrolase//METHENYLTHFCYCLOHYDRO-RXN//METHYLENETHFDEHYDROG-NADP-RXN )</html:p>
<html:p>SUBSYSTEM: reductive acetyl coenzyme A pathway</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__PPENTOMUT__45__RXN" name="Phosphopentomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0214_deoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphopentomutase//D-PPENTOMUT-RXN//PPENTOMUT-RXN )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYLESTERASE__45__RXN" name="Carboxylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0345 ) or ( p12RHILE0556_yaiM ) or ( RHILE1185 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Carboxylesterase//Carboxylesterase ) or ( putative esterase ) or ( putative carboxylesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Carboxylic__45__esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHLAXANAU__45__RXN" name="Haloalkane dehalogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0576 ) or ( p11RHILE0072 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Haloalkane dehalogenase (EC 3.8.1.5)//Haloalkane dehalogenase ) or ( putative Haloalkane dehalogenase//Haloalkane dehalogenase )</html:p>
<html:p>SUBSYSTEM: 1,2-dichloroethane degradation pathway</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_12__45__DICHLOROETHANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="_2__45__CHLOROETHANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2PGADEHYDRAT__45__RXN" name="Phosphopyruvate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2374_eno )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enolase//2PGADEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis+Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMKALT__45__RXN" name="T2-induced deoxynucleotide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1655_gmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanylate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOKIN__45__RXN" name="Gluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0210 ) or ( p10RHILE0427_idnK ) or ( RHILE0826_idnK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( EryA, erythritol kinase ) or ( D-gluconate kinase, thermosensitive//GLUCONOKIN-RXN ) or ( D-gluconate kinase, thermosensitive//GLUCONOKIN-RXN )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>SUBSYSTEM: L-idonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8979" name="2-methylcitrate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0523 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-methylcitrate dehydratase//2-methylcitrate dehydratase )</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__622" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9421" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZYL__45__ALCOHOL__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0536_areB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aryl-alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: m-cresol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OH__45__BENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OH__45__BENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8972" name="UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3542_murE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate 2,6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Lysine__45__or__45__DAP__124__" stoichiometry="1"/>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__UDP__45__N__45__acetylmuramoyl__45__Tripeptide__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERSYN__45__RXN" name="CDP-diacylglycerol--serine O-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1623_pssA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphatidylserine synthase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.8</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOLATEDEHYDRO__45__RXN" name="Glycolate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0913_glcF ) or ( RHILE0912 ) or ( RHILE0911_glcD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycolate oxidase subunit, FeS protein ) or ( putative glycolate oxidase subunit GlcE ) or ( glycolate oxidase, FAD-linked subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation (E. coli)</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation II</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.14</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIOPTERIN_TO_TETRA__45__H__45__BIOPTERIN_COF_RXN" name="BIOPTERIN_TO_TETRA-H-BIOPTERIN_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8976" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3537_murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine:N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase//NACGLCTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7695" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA_TO_CO__45__A_COF_RXN" name="MALONYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAPHTHOATE__45__SYN__45__RXN" name="naphthoate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0178 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dihydroxynaphthoic acid synthetase )</html:p>
<html:p>SUBSYSTEM: menaquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.36</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__SUCCINYLBENZOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="DIHYDROXYNAPHTHOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8975" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3540_mraY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospho-N-acetylmuramoyl-pentapeptide transferase//PHOSNACMURPENTATRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C3" stoichiometry="1"/>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C4" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__88__45__RXN" name="Peptide deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2719 ) or ( RHILE0453_def )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peptide deformylase-like (Polypeptide deformylase-like)//Peptide deformylase ) or ( peptide deformylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.88</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNDECARBOX__45__RXN" name="Ornithine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4437 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ornithine decarboxylase )</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.17</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__KIN__45__RXN" name="Glycerol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2901_glpK ) or ( RHILE3812_glpK ) or ( p9RHILE0089_glpK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol kinase ) or ( glycerol kinase ) or ( glycerol kinase )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.30</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRUVATE__45__REDUCTASE__45__RXN" name="Hydroxypyruvate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2128 ) or ( RHILE1044 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative hydroxypyruvate reductase (EC 1.1.1.81) ) or ( putative hydroxypyruvate reductase (EC 1.1.1.81) )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.81</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0282 ) or ( RHILE3568 ) or ( p10RHILE0127 ) or ( RHILE1585 ) or ( p10RHILE0128 ) or (  ) or (  ) or ( p10RHILE0063_ilvB ) or ( p12RHILE0127 ) or ( RHILE2598_ilvI ) or ( RHILE3469_ilvH ) or ( RHILE3470_ilvI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetolactate synthase large subunit//Acetolactate synthase ) or ( putative Acetolactate synthase//Acetolactate synthase ) or ( putative Acetolactate synthase//Acetolactate synthase ) or ( putative malonic semialdehyde oxidative decarboxylase (EC 1.-.-.-) ) or ( putative Acetolactate synthase//Acetolactate synthase ) or ( Acetolactate synthase large subunit (fragment)//Acetolactate synthase ) or ( Acetolactate synthase large subunit (fragment)//Acetolactate synthase ) or ( putative acetolactate synthase large subunit ) or ( Thiamine pyrophosphate enzyme ) or ( acetolactate synthase III, valine-sensitive, large subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN ) or ( acetolactate synthase III, valine-sensitive, small subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN ) or ( acetolactate synthase III, valine-sensitive, large subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: butanediol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__16__45__RXN" name="Isoquinoline 1-oxidoreductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2662 ) or ( RHILE2661 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative DEHYDROGENASE, LARGE CHAIN OXIDOREDUCTASE PROTEIN (EC 1.-.-.- ) ) or ( Isoquinoline 1-oxidoreductase alpha subunit (EC 1.3.99.16)//Isoquinoline 1-oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOQUINOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOQUINOLIN__45__12H__45__ONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__27__45__RXN" name="Methylmalonate-semialdehyde dehydrogenase (acylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0819 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative malonic semialdehyde oxidative decarboxylase )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.27</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLORAMPHENICOL__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Chloramphenicol O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0177 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acetyltransferase (virginiamycin, streptogramin A, chloramphenicol) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.28</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLORAMPHENICOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLORAMPHENICOL__45__3__45__ACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__RIBULOKIN__45__RXN" name="D-ribulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4494 ) or ( p9RHILE0126 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative SUGAR KINASE PROTEIN (EC 2.7.1.-) ) or ( Ribitol kinase )</html:p>
<html:p>SUBSYSTEM: ribitol degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.47</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__83__45__RXN" name="Dolichyl-phosphate &amp;beta;-D-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3433 ) or ( RHILE1558 ) or ( RHILE3882 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Dolichyl-phosphate beta-D-mannosyltransferase//Dolichyl-phosphate beta-D-mannosyltransferase ) or ( putative GLYCOSYLTRANSFERASE TRANSMEMBRANE PROTEIN ) or ( putative Dolichyl-phosphate beta-D-mannosyltransferase//Dolichyl-phosphate beta-D-mannosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.83</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PMPOXI__45__RXN" name="Pyridoxamine-phosphate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1064_pdxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine 5&apos;-phosphate oxidase//PMPOXI-RXN//PNPOXI-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCORN__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4676 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine aminotransferase 3 (EC 2.6.1.11) (ACOAT 3) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N2__45__SUCCINYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGTPTRIPHYDRO__45__RXN" name="Deoxyguanosinetriphosphate triphosphohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2162 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dGTP triphosphohydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.5.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYGUANOSINE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERATE__45__DEHYDROGENASE__45__RXN" name="Glycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2128 ) or ( RHILE4425 ) or ( RHILE1044 ) or ( p10RHILE0425 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative hydroxypyruvate reductase (EC 1.1.1.81) ) or ( putative glycerate dehydrogenase ) or ( putative hydroxypyruvate reductase (EC 1.1.1.81) ) or ( putative glycerate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.29</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0022_trpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase, alpha protein//TRYPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: GAP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R343__45__RXN" name="Cob(II)yrinic acid a,c-diamide reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2863 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cob(II)yrinic acid a,c-diamide reductase (EC 1.16.8.1) )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 1.16.8.1</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: FMN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__689" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__694" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOINASE__45__RXN" name="Allantoinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p12RHILE0126 ) or ( RHILE0389 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative allantoinase ) or ( putative allantoinase )</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate I (urea producing)</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation (E. coli)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate II (ammonia producing)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate III</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate I</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ALLANTOIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R544__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__865" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__866" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UREA__45__CARBOXYLASE__45__RXN" name="Urea carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0305 ) or ( p9RHILE0306 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative urea amidolyase ) or ( putative Urea carboxylase//Urea carboxylase )</html:p>
<html:p>SUBSYSTEM: urea degradation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__578" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__2__45__3__45__DIOXYGENASE__45__RXN" name="catechol 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3043 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Metapyrocatechase (EC 1.13.11.2) )</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate I (via o-cresol)</html:p>
<html:p>SUBSYSTEM: 2-nitrotoluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate (via toluene-cis-diol)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.2</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__111" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2H6OH2__45__4DIENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__13__45__RXN" name="Mannose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0028 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nucleotidyl transferase )</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.13</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8991" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5001_leuD ) or ( RHILE4850_leuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-isopropylmalate isomerase, subunit with LeuC//3-ISOPROPYLMALISOM-RXN ) or ( 3-isopropylmalate isomerase, subunit with LeuD//3-ISOPROPYLMALISOM-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9451" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8992" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0988_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__1__45__PHOSPHAT__45__RXN" name="Glucose-1-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1750_yfbT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphatase, contains a phosphatase-like domain )</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__D__45__Glucose__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYSYN__45__RXN" name="phosphatidate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2361_cdsA ) or ( p9RHILE0211 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diglyceride synthase//CDPDIGLYSYN-RXN ) or ( putative phosphatidate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.41</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R107__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation I (meta-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__87" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2542" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOADEHYDROG__45__RXN" name="Acyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0411_dcaA ) or ( RHILE4806 ) or ( RHILE0626 ) or ( RHILE1016 ) or ( p10RHILE0332 ) or ( RHILE1847_aidB ) or ( p10RHILE0162 ) or ( p9RHILE0254 ) or ( RHILE4891 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase ) or ( putative acyl-CoA dehydrogenase ) or ( putative acyl-CoA dehydrogenase ) or ( putative acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( putative acyl-CoA dehydrogenase (flavoprotein) , adaptive response (transcription activated by Ada) ) or ( putative acyl-CoA dehydrogenase ) or ( putative acyl-CoA dehydrogenase ) or ( putative acyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBONYL__45__REDUCTASE__45__NADPH__45__RXN" name="Carbonyl reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1681 ) or ( RHILE1508 ) or ( RHILE2507 ) or ( RHILE1158 ) or ( RHILE0672 ) or ( RHILE4509 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative OXIDOREDUCTASE PROTEIN ) or ( putative oxidoreductase (EC 1.-.-.-) ) or ( Protein dltE ) or ( Daunorubicin C-13 ketoreductase ) or ( D-erythrulose reductase (EC 1.1.1.162) ) or ( putative oxidoreductase protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.184</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LONG__45__CHAIN__45__KETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__5__45__EPIMERASE__45__RXN" name="UDP-glucuronate 5&apos;-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3930 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucuronate 5&apos;-epimerase (EC 5.1.3.12) (UDP-glucuronic acid epimerase)//UDP-glucuronate 5&apos;-epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__223" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALISOM__45__RXN" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE5001_leuD ) or ( RHILE4850_leuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-isopropylmalate isomerase, subunit with LeuC//3-ISOPROPYLMALISOM-RXN ) or ( 3-isopropylmalate isomerase, subunit with LeuD//3-ISOPROPYLMALISOM-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9451" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R345__45__RXN" name="Adenosylcobyric acid synthase (glutamine-hydrolyzing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3026_cobQ1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cobyric acid synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__691" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERONE__45__KINASE__45__RXN" name="Glycerone kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3098 ) or ( RHILE1858 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydroxyacetone kinase (EC 2.7.1.29) (Glycerone kinase) (DHA kinase)//Glycerone kinase ) or ( DEOXYRIBONUCLEOSIDE REGULATOR / DIHYDROXYACETONE KINASE (EC 2.7.1.29) )</html:p>
<html:p>SUBSYSTEM: glycerol degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.29</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__34__45__RXN" name="6,7-dihydropteridine reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0510 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 6,7-dihydropteridine reductase//6,7-dihydropteridine reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.34</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5678__45__TETRAHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_67__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOACETYLTRAN__45__RXN" name="Galactoside O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative acetyltransferase C18B11.09c (EC 2.3.1.-) (fragment) ) or ( Acetyl / acyl transferase related protein (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.18</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__D__45__Galactosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__Acetyl__45__Beta__45__D__45__Galactosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOPARATHION__45__PHOSPHATASE__45__RXN" name="Aryldialkylphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p9RHILE0233 ) or ( RHILE3340 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Aryldialkylphosphatase//Aryldialkylphosphatase ) or ( putative Aryldialkylphosphatase//Aryldialkylphosphatase )</html:p>
<html:p>SUBSYSTEM: superpathway of parathion degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__259" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCPDIESTER__45__RXN" name="Glycerophosphodiester phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3348 ) or ( RHILE1371 ) or ( p9RHILE0277 ) or ( p12RHILE0016_ugpQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycerophosphoryl diester phosphodiesterase ) or ( putative Glycerophosphodiester phosphodiesterase//Glycerophosphodiester phosphodiesterase ) or ( putative Glycerophosphodiester phosphodiesterase//Glycerophosphodiester phosphodiesterase ) or ( glycerophosphodiester phosphodiesterase, cytosolic//GLYCPDIESTER-RXN )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.46</html:p>
<html:p>SIDE: __124__Alcohols__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycerophosphodiesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPNACETYLMURAMATEDEHYDROG__45__RXN" name="UDP-N-acetylmuramate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3535_murB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylenolpyruvoylglucosamine reductase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.158</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTODEHYDROG__45__RXN" name="D-galactose 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1666 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Galactose 1-dehydrogenase (EC 1.1.1.48)//Galactose 1-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: galactose degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.48</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GALACTONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMHYDR__45__RXN" name="Fumarate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2887_fumA ) or ( RHILE2885_fumC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarase A (fumarate hydratase class I), aerobic isozyme//FUMHYDR-RXN ) or ( fumarase C (fumarate hydratase Class II)//FUMHYDR-RXN )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETYL__45__COA__45__TRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0310_atoD ) or ( p11RHILE0311_atoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit ) or ( acetyl-CoA:acetoacetyl-CoA transferase, beta subunit )</html:p>
<html:p>SUBSYSTEM: acetoacetate degradation (to acetyl CoA)</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8998" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2360_ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)//RXN0-5180 )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9453" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9452" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8997" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2360_ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)//RXN0-5180 )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9454" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9453" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTUROISOM__45__RXN" name="Glucuronate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0102 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Uronate isomerase (EC 5.3.1.12) (Glucuronate isomerase) (Uronic isomerase)//Glucuronate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of galacturonate and glucuronate degradation</html:p>
<html:p>SUBSYSTEM: D-galacturonate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__TAGATURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8999" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2360_ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)//RXN0-5180 )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9452" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8994" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2360_ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)//RXN0-5180 )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9457" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9456" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRITREDUCT__45__RXN" name="Nitrite reductase (NAD(P)H)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2110 ) or ( RHILE2111_nasD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Nitrite reductase (NAD(P)H)//Nitrite reductase (NAD(P)H) ) or ( nitrite reductase, large subunit, nucleotide- and Fe/S-cluster binding )</html:p>
<html:p>SUBSYSTEM: nitrate reduction V (assimilatory)</html:p>
<html:p>SUBSYSTEM: 2-nitropropane degradation</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.4</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NH4OH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8993" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2360_ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)//RXN0-5180 )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9457" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ANTHRANSYN__45__RXN" name="Anthranilate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3760_trpG ) or ( RHILE2654_trpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anthranilate synthase ) or ( anthranilate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.27</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AROMATIC__45__L__45__AMINO__45__ACID__45__DECARBOXYLASE__45__RXN" name="Aromatic-L-amino-acid decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3211 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative amino acid decarboxylase, Pyridoxal-dependent protein (EC 4.1.1.-) )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VI (via tryptamine)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8996" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2360_ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)//RXN0-5180 )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9455" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9454" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__LYASE__45__RXN" name="Cystathionine &amp;beta;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0397 ) or ( p12RHILE0335 ) or ( RHILE2341_metC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative DEAMINATING CARBON-SULFUR LYASE PROTEIN (EC 4.4.1.-) ) or ( putative lyase ) or ( cystathionine beta-lyase, PLP-dependent (beta-cystathionase)//CYSTATHIONINE-BETA-LYASE-RXN )</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.8</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYMALTOPHOSPHORYL__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4393_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8995" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE2360_ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase)//RXN0-5180 )</html:p>
<html:p>SUBSYSTEM: undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9456" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9455" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0021_trpB ) or ( RHILE0022_trpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase, beta protein//RXN0-2382//TRYPSYN-RXN ) or ( tryptophan synthase, alpha protein//TRYPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMPKI__45__RXN" name="Cytidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0110_cmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine monophosphate (CMP) kinase//CMPKI-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__129__45__RXN" name="Peptidoglycan glycosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0013 ) or ( RHILE3543_ftsI ) or ( RHILE0160 ) or ( RHILE1850 ) or ( RHILE1477 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( penicillin binding protein ) or ( division-specific transpeptidase, penicillin-binding protein 3 ) or ( putative Peptidoglycan glycosyltransferase//Peptidoglycan glycosyltransferase ) or ( putative Peptidoglycan glycosyltransferase//Peptidoglycan glycosyltransferase ) or ( putative penicillin-binding protein ) or ( putative penicillin-binding protein (fragment) ) or ( putative penicillin-binding protein (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.129</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7695" stoichiometry="1"/>
      <speciesReference species="__124__Peptidoglycans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="__124__Peptidoglycans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRS__45__RXN" name="phosphoribosylformylglycinamidine cyclo-ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1689_purM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole synthetase (AIR synthetase)//AIRS-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROPRIBTRANS__45__RXN" name="Orotate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0529 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Orotate phosphoribosyltransferase (EC 2.4.2.10)//Orotate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_SUC__45__COA_COF_RXN" name="CO-A_TO_SUC-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PURIDYLTRANS__45__RXN" name="UTP--glucose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4359_galU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-1-phosphate uridylyltransferase//GLUC1PURIDYLTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis II (from UDP-D-Glucose)</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FOLYLPOLYGLUTAMATESYNTH__45__RXN" name="folylpolyglutamate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0024_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: folylpolyglutamate synthase; dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDLIPOXN__45__RXN" name="Dihydrolipoamide dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4721_lpd ) or ( p10RHILE0336_lpd ) or ( RHILE2381 ) or ( p11RHILE0421_acoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes//RXN-8629//RXN0-1132 ) or ( dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes//RXN-8629//RXN0-1132 ) or ( dihydrolipoamide dehydrogenase, E3 Component of Pyruvate dehydrogenase multienzyme complex ) or ( dihydrolipoamide dehydrogenase (E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1408 ) or ( RHILE3423_ilvE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative branched-chain amino acid aminotransferase ) or ( putative branched-chain amino acid aminotransferase//BRANCHED-CHAINAMINOTRANSFERILEU-RXN//BRANCHED-CHAINAMINOTRANSFERLEU-RXN//BRANCHED-CHAINAMINOTRANSFERVAL-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__884" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1080_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYLPHENOL__45__HYDROX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0391_ubiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-octaprenylphenol hydroxylase of ubiquinone biosynthetic pathway )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYLPHENOL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="HCAMULTI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0669_hcaD ) or ( p11RHILE0670_hcaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylpropionate dioxygenase, ferredoxin reductase subunit//FERREDOXIN--NAD(+)-REDUCTASE-RXN ) or ( phenylpropionate dioxygenase, ferredoxin subunit )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation to 2-oxopent-4-enoate</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.19</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__PHENYLPROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYETHYL__45__3__45__5__45__CYCLOHEXADIENE__45__1__45__2__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__882" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE4927_gcpE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gcpE, Essential bacterial protein, involved in density-dependent regulation of peptidoglycan biosynthesis )</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Protein__45__Disulfides__124__</html:p>
<html:p>SIDE: __124__Protein__45__Dithiols__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSTEINE__45__S__45__METHYLTRANSFERASE__45__RXN" name="Homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( p10RHILE0448 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative homocysteine S-methyltransferase family protein )</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.10</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3443" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3861 ) or ( p10RHILE0271_aldH ) or (  ) or ( p12RHILE0560_aldH ) or ( RHILE4880 ) or ( p8RHILE0077 ) or ( p12RHILE0665_aldH ) or ( RHILE0331 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase ycbD (EC 1.2.1.3) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( phenylacetaldehyde dehydrogenase (fragment) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase family 7 member A1 (EC 1.2.1.3) (Turgor- responsive protein 26G) (Antiquitin 1) ) or ( putative Aldehyde dehydrogenase (NAD+) ) or ( aldehyde dehydrogenase, prefers NADP over NAD ) or ( Aldehyde dehydrogenase (NADP) family protein )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2582" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE1944_xthA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative exonuclease III )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.21.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8533" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8532" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__3__46__1__46__17__45__RXN" name="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p11RHILE0570_kduI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative pectin degrading enzyme 5-keto 4-deoxyuronate isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__37" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__343" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMUR__45__ALA__45__LIG__45__RXN" name="UDP-N-acetylmuramate--alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE3536_murC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetyl-muramate:alanine ligase, L-alanine adding enzyme//UDP-NACMUR-ALA-LIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__ACETYLMURAMOYL__45__ALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHYLGLYCINE__45__DEHYDROGENASE__45__RXN" name="Dimethylglycine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHILE0100 ) or ( p11RHILE0253 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sarcosine dehydrogenase, mitochondrial precursor (EC 1.5.99.1) (SarDH) ) or ( SARCOSINE DEHYDROGENASE (EC 1.5.99.1) )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
