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<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="MOUSE_metabolic_network_metabolic_network" name="Mus musculus">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
  <species id="CPD__45__7229" name="1-(&amp;beta;-D-ribofuranosyl)-1,4-dihydronicotinamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUCURONATE" name="glucuronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Sugar__45__1__45__Phosphate__124__" name="a sugar-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__313" name="1,3-diaminopropane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Monophosphates__124__" name="a ribonucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1082" name="5&amp;beta;-cholestan-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__XYLULOSE" name="L-xylulose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DIHYDROXY__45__PHENYLALANINE" name="L-dopa" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBON__45__MONOXIDE" name="CO" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYLNEURAMINYL__45__ETCETERA__45__GLUCOSYLCERAMI" name="N-acetylneuraminyl-2,3-&amp;alpha;-D-galactosyl-1,4-&amp;beta;-D-glucosylceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Amino__45__Acids__124__" name="a D-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPID" name="lipid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DI__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL" name="N-acetyl-&amp;beta;-D-glucosaminyl-1,2-&amp;alpha;-D-mannosyl-1,3-(N-acetyl-&amp;beta;-D-glucosaminyl-1,2-&amp;alpha;-D-mannosyl-1,6)-&amp;beta;-D-mannosyl-1,4-N-acetyl-&amp;beta;-D-glucosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1087" name="7&amp;alpha;-hydroxycholest-4-en-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GAMMA__45__GLUTAMYLCYSTEINE" name="L-&amp;gamma;-glutamylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP" name="GDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__EPINEPHRINE" name="adrenaline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="APS" name="APS" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__CYSTEINE" name="protein-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" name="an L-1-phosphatidyl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SEDOHEPTULOSE__45__7__45__P" name="D-sedoheptulose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSYLCERAMIDE" name="&amp;beta;-D-galactosyl-1,4-N-acetyl-&amp;beta;-D-glucosaminyl-1,3-&amp;beta;-D-galactosyl-1,4-&amp;beta;-D-glucosylceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROFOLATE" name="7,8-dihydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acceptor__124__" name="an oxidized electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ILE" name="L-isoleucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="glycolithocholate__32__3__45__sulfate" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINAMINE" name="S-adenosyl-L-methioninamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F6" name="N4-{N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,3)-[N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,6)]-&amp;beta;-D-mannosyl-(1,4)-N-acetyl-&amp;beta;-D-glucosaminyl-(1,4)-[&amp;alpha;-L-fucosyl-(1,6)]-N-acetyl-&amp;beta;-D-glucosaminyl}asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXYINDOLE" name="5,6-dihydroxyindole" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__302" name="D-Aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARG" name="L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_7__45__DEHYDRO__45__CHOLESTEROL" name="7-dehydro-cholesterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__ALKYL__45__2__45__ACETYL__45__SN__45__GLYCERO__45__3__45__PHOSPHOCHO" name="1-alkyl-2-acetyl-sn-glycero-3-phosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__CHLORO__45__24__45__DINITROBENZENE" name="1-chloro-2,4-dinitrobenzene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7213" name="[heparan sulfate]-N-sulfoglucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__S__45__Substituted__45__L__45__Cysteines__124__" name="an L-cysteine-S-conjugate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__882" name="1,6-anhMurNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMP" name="IMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TARTRONATE__45__S__45__ALD" name="tartronate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1079" name="&amp;alpha;-aminoadipate 6-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROCOLLAGEN__45__5__45__HYDROXY__45__L__45__LYSINE" name="procollagen-5-hydroxy-L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNOSE" name="mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__11__45__Beta__45__Hydroxysteroids1__124__" name="an 11-&amp;beta;-hydroxysteroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHATIDYLINOSITOL__45__345__45__TRIPHOSPHATE" name="1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__METHYLPHENYLETHANOLAMINE" name="N-methylphenylethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOPROTEIN__45__PHOSPHO__45__D__45__MANNOSE" name="glycoprotein-phospho-D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__2__45__HYDROXYACYLSPHINGOSINE" name="2-(2-hydroxyacyl)sphingosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__335" name="(R)-3-Hydroxybutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__332" name="dihydrozeatin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOAMIDE" name="lipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_23__45__EPOXY__45__23__45__DIHYDRO__45__2__45__METHYL__45__14__45__NAPHTHOQ" name="vitamin K 2,3-epoxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ASN" name="L-asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ASPARTATE" name="L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRI__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL" name="N-acetyl-&amp;beta;-D-glucosaminyl-1,2-&amp;alpha;-D-mannosyl-1,3-(N-acetyl-&amp;beta;-D-glucosaminyl-1,2-&amp;alpha;-D-mannosyl-1,6)-(N-acetyl-&amp;beta;-D-glucosaminyl-1,4)-&amp;beta;-D-mannosyl-1,4-N-acetyl-&amp;beta;-D-glucosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALONATE__45__S__45__ALD" name="malonate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__8" name="ubiquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Donor__45__H2__124__" name="a reduced electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CYSTATHIONINE" name="cystathionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1064" name="lathosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" name="D-myo-inositol (1,3,4)-trisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL" name="pyridoxal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYPOTAURINE" name="hypotaurine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" name="D-myo-inositol (3)-monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__329" name="L-xylo-Hexulonolactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYADENOSINE" name="deoxyadenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__323" name="cholest-4-en-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATP" name="ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" name="UDP-N-acetylgalactosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSINE5TRIPHOSPHO5ADENOSINE" name="adenosine(5&apos;)triphospho(5&apos;)adenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSE" name="&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6141" name="N-methyl-&amp;beta;-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA11__45__ALPHA__45__EPOXY__45__15__45__HYDROXYTHROMBA" name="thromboxane A2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6142" name="N,N-dimethyl-&amp;beta;-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7000" name="isobutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KERATAN" name="keratan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOLLATE" name="glycolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_11__45__DEOXYCORTICOSTERONE" name="11-deoxycorticosterone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH__45__P__45__OR__45__NOP" name="NAD(P)H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="T2__45__DECENOYL__45__COA" name="trans-&amp;Delta;2-decenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__TETRADECANOYLGLYCYL__45__PEPTIDE" name="N-tetradecanoylglycyl-peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__316" name="reduced riboflavin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" name="dTDP-4-dehydro-6-deoxy-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDPDIACYLGLYCEROL" name="a CDP-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4619" name="cis-zeatin-9-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Monophosphates__124__" name="a nucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__LACTATE" name="D-lactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" name="a 2,3,4-saturated fatty acyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__352" name="estradiol-17&amp;beta;" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CANAVANINE" name="canavanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__PROPIONYL__45__COA" name="3-hydroxypropionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__1__45__ARSENATE" name="ribose-1-arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__3__45__HYDROXYACYL__45__COA" name="a (3S)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TYR" name="L-tyrosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARSENATE" name="arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5678__45__TETRAHYDROPTERIDINE" name="5,6,7,8-tetrahydropteridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MONONUCLEOTIDE" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4620" name="cis-zeatin-O-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4621" name="dihydrozeatin-9-N-glucoside-O-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4622" name="trans-zeatin-O-glucoside-7-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" name="FF-MAS" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHYTOCERAMIDE" name="phytoceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE" name="N-acetyl-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THREO__45__DS__45__ISO__45__CITRATE" name="isocitrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LYS" name="L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_44__45__DIMETHYL__45__5ALPHA__45__CHOLEST__45__7__45__EN__45__3BET" name="4,4-dimethyl-5&amp;alpha;-cholest-7-en-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENYLOSUCC" name="adenylo-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__BETA__45__D__45__GALACTOSYL__45__2__45__2__45__HYDROXYACYLS" name="1-(&amp;beta;-D-galactosyl)-2-(2-hydroxyacyl)sphingosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__342" name="5&amp;alpha;-Androstane-3,17-dione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUMP" name="dUMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BENZENAMINE__45__SULFATE" name="benzenamine sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1242" name="3-keto-&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALO__45__SUCCINATE" name="oxalosuccinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__339" name="6-phospho-2-dehydro-D-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DOPACHROME" name="L-dopachrome" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOPORPHYRIN_IX" name="protoporphyrin IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="A__45__3__45__OXO__45__ACYL__45__COA" name="a 3-oxo-acyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIALKYL__32__PHOSPHATE" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALLO__45__THR" name="allothreonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__371" name="1-octanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UROPORPHYRINOGEN__45__III" name="uroporphyrinogen-III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__HYDROXYPHYTANOYL__45__COA" name="2-hydroxyphytanoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCERATE" name="glycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIETHYLTHIOPHOSPHATE" name="diethylthiophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__374" name="sepiapterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7035" name="2-phenylethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__L__45__1__45__phosphatidyl__45__inositols__124__" name="an L-1-phosphatidyl-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7037" name="methionol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__THYROXINE" name="L-thyroxine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__MERCAPTO__45__PYRUVATE" name="3-mercaptopyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7036" name="3-methylthiopropanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7031" name="3-methylbutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="M__40__7__41__G__40__5__38__amp__59__apos__59____41__PPPM__40__6__41__AM" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="CPD__45__7033" name="2-methylbutanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2K__45__ADIPATE" name="&amp;alpha;-ketoadipate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_56__45__DIHYDROXYINDOLE__45__2__45__CARBOXYLATE" name="5,6-dihydroxyindole-2-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="POLYPEPTIDE" name="a polypeptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LINOLEIC_ACID" name="linoleate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__369" name="L-iditol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORSSMAN__45__HAPTEN" name="forssman hapten" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4604" name="benzyladenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BETA__45__HYDROXY__45__4BETA__45__METHYL__45__5ALPHA__45__CHOLEST" name="3&amp;beta;-hydroxy-4&amp;beta;-methyl-5&amp;alpha;-cholest-7-ene- 4&amp;alpha;-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="CPD__45__4602" name="isopentenyladenine-7-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4603" name="isopentenyladenine-9-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIOTHYRONINE" name="L-triiodothyronine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__360" name="D-xylonolactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Keto__45__Acid__124__" name="a keto acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHOLESTEROL" name="cholesterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__BETA__45__GLUCOSAMINYLAMINE" name="N-acetyl-&amp;beta;-glucosaminylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4609" name="kinetin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXIDIZED__32__RUBREDOXIN" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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<html:p>GENE_ASSOCIATION: ( Acly )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP citrate lyase )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA biosynthesis (from citrate)</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.8</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: OXALACETIC_ACID</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
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      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
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    <listOfProducts>
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<html:p>GENE_ASSOCIATION: ( Gcat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine C-acetyltransferase (2-amino-3-ketobutyrate-coenzyme A ligase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.29</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
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    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
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<html:p>GENE_ASSOCIATION: ( Ndst1 ) or ( Ndst4 ) or ( Ndst2 ) or ( Ndst3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 ) or ( N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4 ) or ( N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 ) or ( N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.8</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HEPARIN__45__GLUCOSAMINE" stoichiometry="1"/>
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    <listOfProducts>
      <speciesReference species="CPD__45__7213" stoichiometry="1"/>
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<html:p>GENE_ASSOCIATION: ( Gstt1 ) or ( Gsta2 ) or ( Gstm6 ) or ( Mgst3 ) or ( Gsta3 ) or ( Gstm2 ) or ( Gstz1 ) or ( Gstt3 ) or ( Gstp1 ) or ( Gsto1 ) or ( Gsta ) or ( Gstm4 ) or ( Gsto2 ) or ( Gstm7 ) or ( Gsta1 ) or ( Mgst1 ) or ( Gstm3 ) or ( Gstt2 ) or ( Gsta4 ) or ( Gstk1 ) or ( Gstm5 ) or ( Gstm1 ) or ( Gstp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione S-transferase, theta 1 ) or ( glutathione S-transferase, alpha 2 (Yc2) ) or ( glutathione S-transferase, mu 6 ) or ( microsomal glutathione S-transferase 3 ) or ( glutathione S-transferase, alpha 3 ) or ( glutathione S-transferase, mu 2 ) or ( glutathione transferase zeta 1 (maleylacetoacetate isomerase) ) or ( glutathione S-transferase, theta 3 ) or ( glutathione S-transferase, pi 1 ) or ( glutathione S-transferase omega 1 ) or ( glutathione S-transferase cluster ) or ( glutathione S-transferase, mu 4 ) or ( glutathione S-transferase omega 2 ) or ( glutathione S-transferase, mu 7 ) or ( glutathione S-transferase, alpha 1 (Ya) ) or ( microsomal glutathione S-transferase 1 ) or ( glutathione S-transferase, mu 3 ) or ( glutathione S-transferase, theta 2 ) or ( glutathione S-transferase, alpha 4 ) or ( glutathione S-transferase kappa 1 ) or ( glutathione S-transferase, mu 5 ) or ( glutathione S-transferase, mu 1 ) or ( glutathione S-transferase, pi 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
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      <speciesReference species="_1__45__CHLORO__45__24__45__DINITROBENZENE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
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    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="S__45__24__45__DINITROPHENYLGLUTATHIONE" stoichiometry="1"/>
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  <reaction id="_1__45__PHOSPHATIDYLINOSITOL__45__KINASE__45__RXN" name="1-phosphatidylinositol 4-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pi4k2a ) or ( Pi4kb ) or ( Pi4k2b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 4-kinase type 2 alpha ) or ( phosphatidylinositol 4-kinase, catalytic, beta polypeptide ) or ( phosphatidylinositol 4-kinase type 2 beta )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.67</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
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    <listOfProducts>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
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  <reaction id="ALDHDEHYDROG__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh5 ) or ( Aldh1a3 ) or ( Aldh2 ) or ( Aldh9a1 ) or ( Aldh3b1 ) or ( Aldh3a2 ) or ( Aldh7a1 ) or ( Aldh3a1 ) or ( Aldh1b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 5, testis ) or ( aldehyde dehydrogenase family 1, subfamily A3 ) or ( aldehyde dehydrogenase 2, mitochondrial ) or ( aldehyde dehydrogenase 9, subfamily A1 ) or ( aldehyde dehydrogenase 3 family, member B1 ) or ( aldehyde dehydrogenase family 3, subfamily A2 ) or ( aldehyde dehydrogenase family 7, member A1 ) or ( aldehyde dehydrogenase family 3, subfamily A1 ) or ( aldehyde dehydrogenase 1 family, member B1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Alox5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 5-lipoxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLENIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R15__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine aminotransferase )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.5</html:p>
<html:p>SIDE: __124__Keto__45__Acid__124__</html:p>
<html:p>SIDE: __124__Amino__45__Acid__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Amino__45__Acid__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="__124__Keto__45__Acid__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLPYRUVATE__45__TAUTOMERASE__45__RXN" name="Phenylpyruvate tautomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mif )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( macrophage migration inhibitory factor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ENOL__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENETHFDEHYDROG__45__NADP__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mthfd2 ) or ( Mthfd1l ) or ( Mthfd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase ) or ( methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like ) or ( methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__NH3__45__RXN" name="GMP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gmps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine monphosphate synthetase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SEDOHEPTULOKINASE__45__RXN" name="Sedoheptulokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Shpk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sedoheptulokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SEDOHEPTULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLGLUCOSAMINE__45__KINASE__45__RXN" name="N-acetylglucosamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nagk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.59</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOSINE__45__DEHYDROGENASE__45__RXN" name="Sarcosine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sardh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sarcosine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__56__45__RXN" name="Lipopolysaccharide N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B3gnt5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.56</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Lipopolysaccharides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__ETCETERA__45__LIPOPOLYSACCHARIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSLIG__45__RXN" name="Phosphopantothenate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ppcs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphopantothenoylcysteine synthetase )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYL__45__SULFOTRANSFERASE__45__RXN" name="Aryl sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sult1a1 ) or ( Sult1b1 ) or ( Sult1c1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfotransferase family 1A, phenol-preferring, member 1 ) or ( sulfotransferase family 1B, member 1 ) or ( sulfotransferase family, cytosolic, 1C, member 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.1</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARYL__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__17__45__RXN" name="Bis(5&apos;-nucleosyl)-tetraphosphatase (asymmetrical)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nudt2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nudix (nucleoside diphosphate linked moiety X)-type motif 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P1P4__45__BIS5__45__NUCLEOSYL__45__TETRAPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
      <speciesReference species="__124__Nucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLESTANETRIOL__45__26__45__MONOOXYGENASE__45__RXN" name="Cholestanetriol 26-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp27a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 27, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.15</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__BETA__45__CHOLESTANE__45__3__45__ALPHA7__45__ALPHA12__45__ALP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__BETA__45__CHOLESTANE__45__3__45__ALPHA7__45__TETRAOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__9__45__RXN" name="Saccharopine dehydrogenase (NAD+, L-glutamate forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sccpdh ) or ( Aass )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( saccharopine dehydrogenase (putative) ) or ( catalytic activity )</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__198__45__RXN" name="Phosphatidylinositol N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pigc ) or ( Pigh ) or ( Pigp ) or ( Pigq )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol glycan anchor biosynthesis, class C ) or ( phosphatidylinositol glycan anchor biosynthesis, class H ) or ( phosphatidylinositol glycan anchor biosynthesis, class P ) or ( phosphatidylinositol glycan anchor biosynthesis, class Q )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.198</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__452" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKYLGLYCERONE__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="Alkylglycerone-phosphate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Agps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alkylglycerone phosphate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.26</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__a__45__long__45__chain__45__alcohol__124__" stoichiometry="1"/>
      <speciesReference species="_1__45__ACYL__45__GLYCERONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__ALKYL__45__GLYCERONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__969" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hao3 ) or ( Hao1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacid oxidase (glycolate oxidase) 3 ) or ( hydroxyacid oxidase 1, liver )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__50__45__RXN" name="3-&amp;alpha;-hydroxysteroid dehydrogenase (B-specific)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hpgd ) or ( Akr1c14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyprostaglandin dehydrogenase 15 (NAD) ) or ( aldo-keto reductase family 1, member C14 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.50</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ANDROSTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__342" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKANE__45__1__45__MONOOXYGENASE__45__RXN" name="Alkane-1 monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp4a14 ) or ( Cyp4a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 4, subfamily a, polypeptide 14 ) or ( cytochrome P450, family 4, subfamily a, polypeptide 10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.15.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__148" stoichiometry="1"/>
      <speciesReference species="REDUCED__45__RUBREDOXIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__32__RUBREDOXIN" stoichiometry="1"/>
      <speciesReference species="OCTANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__151__45__RXN" name="N-acetyllactosaminide &amp;alpha;-1,3-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B3gnt3 ) or ( B3gnt5 ) or ( B4galt2 ) or ( B3gnt4 ) or ( B3galt5 ) or ( B3galt2 ) or ( Ggta1 ) or ( B3galnt2 ) or ( B3galt1 ) or ( B3gnt2 ) or ( B4galt6 ) or ( A3galt2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 ) or ( UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 ) or ( UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 ) or ( UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 ) or ( UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 ) or ( UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 ) or ( glycoprotein galactosyltransferase alpha 1, 3 ) or ( UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2 ) or ( UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 ) or ( UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 ) or ( UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 ) or ( alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.87</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__2__46__30__45__RXN" name="[Heparan sulfate]-glucosamine 3-sulfotransferase 3" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hs3st3b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.30</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__heparan__32__sulfate__93____45__glucosamine" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__heparan__32__sulfate__93____45__glucosamine__32__3__45__sulfate" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPYROPHOSPHAT__45__RXN" name="NAD+ pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nudt12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nudix (nucleoside diphosphate linked moiety X)-type motif 12 )</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROCANATE__45__HYDRATASE__45__RXN" name="Urocanate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Uroc1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( urocanase domain containing 1 )</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.49</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROCANATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__11__46__1__46__12__45__RXN" name="Phospholipid-hydroperoxide glutathione peroxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpx4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione peroxidase 4 )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.12</html:p>
<html:p>SIDE: LIPID</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: A__45__LIPID__45__HYDROPEROXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__LIPID__45__HYDROPEROXIDE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="2"/>
      <speciesReference species="LIPID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__3__45__PHOSPHATE__45__DEHYDROGENASE__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpd2 ) or ( Gpd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol phosphate dehydrogenase 2, mitochondrial ) or ( glycerol-3-phosphate dehydrogenase 1 (soluble) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6201" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: urate degradation to allantoin</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5821" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLANTOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROID__45__DELTA__45__ISOMERASE__45__RXN" name="Steroid &amp;delta;-isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd3b6 ) or ( Hsd3b1 ) or ( Hsd3b2 ) or ( Hsd3b7 ) or ( Hsd3b3 ) or ( Hsd3b4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__oxo__45__D5__45__steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Oxo__45__Delta__45__4__45__Steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGANINE__45__KINASE__45__RXN" name="Sphinganine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sphk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingosine kinase 1 )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.91</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__GALACTOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-GALACTOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROCOLLAGEN__45__PROLINE__45__3__45__DIOXYGENASE__45__RXN" name="Procollagen-proline 3-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Leprel2 ) or ( Leprel1 ) or ( Lepre1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( leprecan-like 2 ) or ( leprecan-like 1 ) or ( leprecan 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.7</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROCOLLAGEN__45__L__45__PROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROCOLLAGEN__45__3__45__HYDROXY__45__L__45__PROLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLN_TO_GLT_COF_RXN" name="GLN_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__4__46__11__45__RXN" name="Biotin--[methylcrotonoyl-CoA-carboxylase] ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hlcs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.11</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APO__45____91__3__45__METHYLCROTONOYL__45__COA__58__CARBON__45__DIOXIDE__32__LIGASE__32____40__ADP__45__FORMING__41____93__" stoichiometry="1"/>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__3__45__METHYLCROTONOYL__45__COA__58__CARBON__45__DIOXIDE__32__LIGASE__32____40__ADP__45__FORMING__41____93__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAICARSYN__45__RXN" name="Phosphoribosylaminoimidazole-succinocarboxamide synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Paics )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLFORMAMIDASE__45__RXN" name="Arylformamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( For4 ) or ( For5 ) or ( Afmid ) or ( For3 ) or ( For1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formamidase 4 ) or ( formamidase 5 ) or ( arylformamidase ) or ( formamidase 3 ) or ( formamidase 1 )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.9</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__FORMYLKYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__41__45__RXN" name="Polypeptide N-acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Galnt3 ) or ( Galnt10 ) or ( Galnt13 ) or ( Galntl1 ) or ( Galnt2 ) or ( Galnt12 ) or ( Galnt4 ) or ( Galnt1 ) or ( Galnt5 ) or ( Galnt6 ) or ( Galnt7 ) or ( Galnt14 ) or ( Galntl2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 1 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 5 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 ) or ( UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.41</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLYPEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINYL__45__POLYPEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R146__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adi1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acireductone dioxygenase 1 )</html:p>
<html:p>SUBSYSTEM: methylthiopropionate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.53</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__MONOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
      <speciesReference species="CPD__45__7672" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIMETHYLLYSINE__45__DIOXYGENASE__45__RXN" name="Trimethyllysine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tmlhe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trimethyllysine hydroxylase, epsilon )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.8</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N6N6N6__45__TRIMETHYL__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__N6N6N6__45__TRIMETHYL__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__206" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aoc3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amine oxidase, copper containing 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP_TO_GDP__45__MANNOSE_COF_RXN" name="GDP_TO_GDP-MANNOSE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__88__45__RXN" name="Globoside &amp;alpha;-N-acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gbgt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.88</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINYL__45__13__45__D__45__GALACT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORSSMAN__45__HAPTEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINE__45__NUCLEOSIDASE__45__RXN" name="Uridine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ung )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uracil DNA glycosylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URPHOS__45__RXN" name="Uridine phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Upp1 ) or ( Upp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine phosphorylase 1 ) or ( uridine phosphorylase 2 )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AGMATIN__45__RXN" name="Agmatinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Agmat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( agmatine ureohydrolase (agmatinase) )</html:p>
<html:p>SUBSYSTEM: arginine degradation III (arginine decarboxylase/agmatinase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AGMATHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOLACTOSE__45__RXN" name="&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Glb1l2 ) or ( Glb1 ) or ( Glb1l3 ) or ( Lct )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactosidase, beta 1-like 2 ) or ( galactosidase, beta 1 ) or ( galactosidase, beta 1 like 3 ) or ( lactase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.23</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOLACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1242" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__271__45__RXN" name="GDP-L-fucose synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tsta3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tissue specific transplantation antigen P35B )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.271</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__92__45__RXN" name="Pantetheine hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Vnn1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( vanin 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.92</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__511" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__239" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTODEXGLUCOSID__45__RXN" name="&amp;alpha;-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gaa ) or ( Mgam ) or ( Ganab )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosidase, alpha, acid ) or ( maltase-glucoamylase ) or ( alpha glucosidase 2 alpha neutral subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__18__45__RXN" name="Phytanoyl-CoA dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Phyhd1 ) or ( Phyhipl ) or ( Phyhip ) or ( Phyh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phytanoyl-CoA dioxygenase domain containing 1 ) or ( phytanoyl-CoA hydroxylase interacting protein-like ) or ( phytanoyl-CoA hydroxylase interacting protein ) or ( phytanoyl-CoA hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.18</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__206" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXYPHYTANOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SEPIAPTERIN__45__REDUCTASE__45__RXN" name="Sepiapterin reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Spr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sepiapterin reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.153</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__374" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCOSE_TO_UDP_COF_RXN" name="UDP-GLUCOSE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__2__45__RXN" name="Dihydropyrimidine dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dpyd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydropyrimidine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FERRIC__45__CHELATE__45__REDUCTASE__45__RXN" name="Ferric-chelate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Frrs1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferric-chelate reductase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.16.1.7</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FE__43__2" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FE__43__3" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLNEURAMINATE__45__CYTIDYLYLTRANSFERASE__45__RXN" name="Acylneuraminate cytidylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cmas )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine monophospho-N-acetylneuraminic acid synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.43</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1119" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__189" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ggt7 ) or ( Ggt2 ) or ( Ggt6 ) or ( Ggt1 ) or ( Ggt5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamyltransferase 7 ) or ( gamma-glutamyltransferase activity ) or ( gamma-glutamyltransferase 6 ) or ( gamma-glutamyltransferase 1 ) or ( gamma-glutamyltransferase 5 )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>SIDE: __124__Amino__45__Acid__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acid__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
      <speciesReference species="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GANGLIOSIDE__45__GALACTOSYLTRANSFERASE__45__RXN" name="Ganglioside galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B3galt4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.62</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINYL__45____40__N__45__ACETYLNEURAMINYL__41____45__D__45__GALACTOSYL__45__D__45__GLUCOSYL__45__N__45__ACYLSPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GALACTOSYL__45__N__45__ACETYL__45__D__45__GALACTOSAMINYL__45____40__N__45__ACETYLNEURAMINYL__41____45__D__45__GALACTOSYL__45__D__45__GLUCOSYL__45__N__45__ACYLSPHINGOSINE" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__1__45__DEHYDROGENASE__45__RXN" name="Glucose 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( H6pd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.47</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__DEHYDROGENASE__45__NADORNOP__43____45__RXN" name="Aldehyde dehydrogenase (NAD(P)+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh1a3 ) or ( Aldh3b1 ) or ( Aldh3a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family 1, subfamily A3 ) or ( aldehyde dehydrogenase 3 family, member B1 ) or ( aldehyde dehydrogenase family 3, subfamily A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG6PDEACET__45__RXN" name="N-acetylglucosamine-6-phosphate deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Amdhd2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidohydrolase domain containing 2 )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__19__46__3__45__RXN" name="Linoleoyl-CoA desaturase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fads1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acid desaturase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.19.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__18" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__LINOLENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__GLU__45__AMINOTRANSFORASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Oat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine aminotransferase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis V (from arginine)</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation (arginase pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__OCTANOYLTRANSFERASE__45__RXN" name="Carnitine O-octanoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Crot )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine O-octanoyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.137</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTANOYL__45__COA" stoichiometry="1"/>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="L__45__OCTANOYLCARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMPCYCLOHYDROLASE__45__RXN" name="IMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Atic )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOKIN__45__RXN" name="Galactokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Galk1 ) or ( Galk2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactokinase 1 ) or ( galactokinase 2 )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3781" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Me1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malic enzyme 1, NADP(+)-dependent, cytosolic )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.39</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__34__45__RXN" name="Hydroxymethylglutaryl-CoA reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hmgcs1 ) or ( Hmgcr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 ) or ( 3-hydroxy-3-methylglutaryl-Coenzyme A reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARACHIDONATE__45__8__45__LIPOXYGENASE__45__RXN" name="Arachidonate 8-lipoxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Alox8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 8-lipoxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.40</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z9E11Z14Z__45__8R__45__8__45__HYDROPEROXYICOSA__45__TETRAEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPXPRIBOSYLTRAN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hprt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine guanine phosphoribosyl transferase 1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__15__45__RXN" name="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dpagt1 ) or ( Gnptab )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) ) or ( N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.15</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="CPD__45__190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOPACHROME__45__DELTA__45__ISOMERASE__45__RXN" name="Dopachrome isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dct )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dopachrome tautomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DOPACHROME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_56__45__DIHYDROXYINDOLE__45__2__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__8__45__RXN" name="Saccharopine dehydrogenase (NADP+, L-lysine forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aass )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catalytic activity )</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNP__45__RXN" name="Purine-nucleoside phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnp1 ) or ( Pnp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase 1 ) or ( purine-nucleoside phosphorylase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENMETSYN__45__RXN" name="Methionine adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mat2a ) or ( Mat1a ) or ( Mat2b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methionine adenosyltransferase II, alpha ) or ( methionine adenosyltransferase I, alpha ) or ( methionine adenosyltransferase II, beta )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4210" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhcr7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4126" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4127" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R22__45__RXN" name="Butyryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acads )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-Coenzyme A dehydrogenase, short chain )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOX__45__RXN" name="Sarcosine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pipox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pipecolic acid oxidase )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDEHYDE__45__OXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh5 ) or ( Aldh1a3 ) or ( Aldh2 ) or ( Aldh9a1 ) or ( Aldh3b1 ) or ( Aldh3a2 ) or ( Aldh7a1 ) or ( Aldh3a1 ) or ( Aldh1b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 5, testis ) or ( aldehyde dehydrogenase family 1, subfamily A3 ) or ( aldehyde dehydrogenase 2, mitochondrial ) or ( aldehyde dehydrogenase 9, subfamily A1 ) or ( aldehyde dehydrogenase 3 family, member B1 ) or ( aldehyde dehydrogenase family 3, subfamily A2 ) or ( aldehyde dehydrogenase family 7, member A1 ) or ( aldehyde dehydrogenase family 3, subfamily A1 ) or ( aldehyde dehydrogenase 1 family, member B1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__358" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLAMIDOGLYCOLATE__45__LYASE__45__RXN" name="Peptidylamidoglycolate lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pam )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptidylglycine alpha-amidating monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__39" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PEPTIDAMIDE__45__CPD" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Prodh2 ) or ( Prodh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline dehydrogenase (oxidase) 2 ) or ( proline dehydrogenase )</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__710" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd3b6 ) or ( Hsd3b1 ) or ( Hsd3b2 ) or ( Hsd3b3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.145</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__708" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__698" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSOPHOSPHOLIPASE__45__RXN" name="Lysophospholipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lypla1 ) or ( Lypla3 ) or ( Lypla2 ) or ( Pla2g4a ) or ( A530050D06Rik ) or ( Clc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysophospholipase 1 ) or ( lysophospholipase 3 ) or ( lysophospholipase 2 ) or ( phospholipase A2, group IVA (cytosolic, calcium-dependent) ) or ( RIKEN cDNA A530050D06 gene ) or ( Charcot-Leyden crystal protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__GLYCERO__45__PHOSPHORYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHACYL__45__COA__45__DEHYDROG__45__RXN" name="3-hydroxyacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b4 ) or ( Hadh ) or ( Hsd17b10 ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxysteroid (17-beta) dehydrogenase 4 ) or ( hydroxyacyl-Coenzyme A dehydrogenase ) or ( hydroxysteroid (17-beta) dehydrogenase 10 ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__1__45__RXN" name="&amp;gamma;-butyrobetaine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Bbox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-butyrobetaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.1</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAMMA__45__BUTYROBETAINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__141__45__RXN" name="15-hydroxyprostaglandin dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hpgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyprostaglandin dehydrogenase 15 (NAD) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.141</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5Z13E__45__15S__45__11__45__ALPHA15__45__DIHYDROXY__45__9__45__O__45__ENOAT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__11__45__ALPHA__45__HYDROXY__45__915__45__DIOXOPROS__45__ENO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DLACTDEHYDROGNAD__45__RXN" name="D-lactate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ldhd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-lactate dehydrogenase (cytochrome) activity )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.28</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7799" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cerk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceramide kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.138</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Plant__45__Ceramide__45__Phosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLGLYCEROL__45__KINASE__45__RXN" name="Acylglycerol kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Agk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acylglycerol kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.94</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__504" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGANINE__45__1__45__PHOSPHATE__45__ALDOLASE__45__RXN" name="Sphinganine-1-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sgpl1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingosine phosphate lyase 1 )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.27</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMITALDEHYDE" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIPHOSPHATASE__45__RXN" name="Nucleoside-diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Entpd5 ) or ( Nudt9 ) or ( Cant1 ) or ( Entpd3 ) or ( Nudt5 ) or ( Entpd4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleoside triphosphate diphosphohydrolase 5 ) or ( nudix (nucleoside diphosphate linked moiety X)-type motif 9 ) or ( calcium activated nucleotidase 1 ) or ( ectonucleoside triphosphate diphosphohydrolase 3 ) or ( nudix (nucleoside diphosphate linked moiety X)-type motif 5 ) or ( ectonucleoside triphosphate diphosphohydrolase 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" name="L-ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__SULFOGLUCOSAMINE__45__SULFOHYDROLASE__45__RXN" name="N-sulfoglucosamine sulfohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sgsh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-sulfoglucosamine sulfohydrolase (sulfamidase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.10.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__550" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OXOACID__45__COA__45__TRANSFERASE__45__RXN" name="3-oxoacid CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Oxct2a ) or ( Oxct1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxoacid CoA transferase 2A ) or ( 3-oxoacid CoA transferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__3__45__OXO__45__ACID" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="A__45__3__45__OXO__45__ACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP_TO_UTP_COF_RXN" name="UDP_TO_UTP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPH__45__DEHYDROGENASE__45__FLAVIN__45__RXN" name="NADPH dehydrogenase (flavin)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Blvrb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biliverdin reductase B (flavin reductase (NADPH)) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.30</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__316" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOICASE__45__RXN" name="Allantoicase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Allc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allantoicase )</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate I (urea producing)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETATE__45____45__COA__45__LIGASE__45__RXN" name="Acetoacetate--CoA ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aacs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetoacetyl-CoA synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.16</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fpgs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamyl synthetase )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Ubiquinones__124___TO___124__Ubiquinols__124___COF_RXN" name="|Ubiquinones|_TO_|Ubiquinols|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Ubiquinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ubiquinols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADP__45__RIBOSYLARGININE__45__HYDROLASE__45__RXN" name="ADP-ribosylarginine hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Adprh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-ribosylarginine hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__557" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE_DIPHOSPHATE_RIBOSE" stoichiometry="1"/>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE_TO_UDP_COF_RXN" name="UDP-GLUCURONATE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__84__45__RXN" name="D-dopachrome decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ddt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-dopachrome tautomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.84</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7272" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXYINDOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__127__45__RXN" name="1D-myo-inositol-trisphosphate 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Itpkb ) or ( Itpkc ) or ( Itpka )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol 1,4,5-trisphosphate 3-kinase B ) or ( inositol 1,4,5-trisphosphate 3-kinase C ) or ( inositol 1,4,5-trisphosphate 3-kinase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.127</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYCYTIDINE__45__KINASE__45__RXN" name="Deoxycytidine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dck )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxycytidine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.74</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__47__45__RXN" name="4-trimethylammoniobutyraldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh9a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 9, subfamily A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.47</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__TRIMETHYLAMMONIOBUTANAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__BUTYROBETAINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_DIHYDROFOLATE_COF_RXN" name="METHYLENE-THF_TO_DIHYDROFOLATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UGD__45__RXN" name="UDP-glucose 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose dehydrogenase )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-D-xylose biosynthesis</html:p>
<html:p>SUBSYSTEM: Vitamin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERCAPYSTRANS__45__RXN" name="3-mercaptopyruvate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mpst )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mercaptopyruvate sulfurtransferase )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.2</html:p>
<html:p>SIDE: HSCN</html:p>
<html:p>SIDE: HCN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCN" stoichiometry="1"/>
      <speciesReference species="_3__45__MERCAPTO__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HSCN" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Choline O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Chat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.6</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__21__45__RXN" name="Farnesyl-diphosphate farnesyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdft1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl diphosphate farnesyl transferase 1 )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__137__45__RXN" name="Arsenite methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( As3mt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arsenic (+3 oxidation state) methyltransferase )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.137</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__763" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLARSONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aco2 ) or ( Aco1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitase 2, mitochondrial ) or ( aconitase 1 )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R481__45__RXN" name="Glycine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gnmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.156</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDYLATE__45__SYNTHASE__45__RXN" name="Pseudouridylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Trub1 ) or ( Nr2e3 ) or ( Pus1 ) or ( Pus7 ) or ( Pus3 ) or ( Nr2e1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TruB pseudouridine (psi) synthase homolog 1 (E. coli) ) or ( nuclear receptor subfamily 2, group E, member 3 ) or ( pseudouridine synthase 1 ) or ( pseudouridylate synthase 7 homolog (S. cerevisiae) ) or ( pseudouridine synthase 3 ) or ( nuclear receptor subfamily 2, group E, member 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.70</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIACYLGLYCEROL__45__LIPASE__45__RXN" name="Triacylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Lipe ) or ( Pnliprp1 ) or ( Pnliprp2 ) or ( Cel ) or ( Lipf ) or ( Lipc ) or ( Dagla ) or ( Lipk ) or ( Daglb ) or ( Lipg ) or ( Pnpla3 ) or ( AI747699 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipase, hormone sensitive ) or ( pancreatic lipase related protein 1 ) or ( pancreatic lipase-related protein 2 ) or ( carboxyl ester lipase ) or ( lipase, gastric ) or ( lipase, hepatic ) or ( diacylglycerol lipase, alpha ) or ( lipase, family member K ) or ( diacylglycerol lipase, beta ) or ( lipase, endothelial ) or ( patatin-like phospholipase domain containing 3 ) or ( expressed sequence AI747699 )</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Fatty__45__Acids__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHOSINEPHOSPHORY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnp1 ) or ( Pnp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase 1 ) or ( purine-nucleoside phosphorylase 2 )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOPROTEIN__45__PHOSPHOLIPASE__45__D__45__RXN" name="Glycoprotein phospholipase D" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpld1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycosylphosphatidylinositol specific phospholipase D1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.50</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1113" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
      <speciesReference species="_6__45__ALPHA__45__D__45__GLUCOSAMINYL__45__1D__45__MYO__45__INOSIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINE__45__DEHYDROGENASE__45__RXN" name="Spermidine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Paox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyamine oxidase (exo-N4-amino) )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.6</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__DELTA__45__ISOM__45__RXN" name="Dodecenoyl-CoA &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dci ) or ( Peci ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenyme A isomerase) ) or ( peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation III (unsaturated, odd number)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__DELTA3__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7143" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdps ) or ( Ggps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl diphosphate synthetase ) or ( geranylgeranyl diphosphate synthase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6644" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdps ) or ( Ggps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl diphosphate synthetase ) or ( geranylgeranyl diphosphate synthase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6642" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPOPROTEIN__45__LIPASE__45__RXN" name="Lipoprotein lipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lpl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipoprotein lipase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.34</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gfpt1 ) or ( Gfpt2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamine fructose-6-phosphate transaminase 1 ) or ( glutamine fructose-6-phosphate transaminase 2 )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.16</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__HYDRAT__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hadha ) or ( Echs1 ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit ) or ( enoyl Coenzyme A hydratase, short chain, 1, mitochondrial ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PALMITYL__45__COA_TO_CO__45__A_COF_RXN" name="PALMITYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PALMITYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULOKIN__45__RXN" name="L-ribulokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fggy )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FGGY carbohydrate kinase domain containing )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.16</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__RIBULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__RIBULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__ASPARTATE__45__OXIDASE__45__RXN" name="D-aspartate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ddo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-aspartate oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__302" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5781" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Chpt1 ) or ( Cept1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline phosphotransferase 1 ) or ( choline/ethanolaminephosphotransferase 1 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.2</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__PEROXIDASE__45__RXN" name="glutathione peroxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpx3 ) or ( Gpx6 ) or ( Gpx7 ) or ( Gpx2 ) or ( 2310016C16Rik ) or ( Gpx5 ) or ( Gpx4 ) or ( Gpx1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione peroxidase 3 ) or ( glutathione peroxidase 6 ) or ( glutathione peroxidase 7 ) or ( glutathione peroxidase 2 ) or ( RIKEN cDNA 2310016C16 gene ) or ( glutathione peroxidase 5 ) or ( glutathione peroxidase 4 ) or ( glutathione peroxidase 1 )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.9</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXI__45__RXN" name="Lactoylglutathione lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Glo1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxalase 1 )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.5</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp51 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 51 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4573" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__74__45__RXN" name="Pyridoxal phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pdxp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal (pyridoxine, vitamin B6) phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.74</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp51 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 51 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4568" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4573" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp51 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 51 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4568" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__139__45__RXN" name="1D-myo-inositol-trisphosphate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Itpk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol 1,3,4-triphosphate 5/6 kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.134</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__306" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tm7sf2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transmembrane 7 superfamily member 2 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENDECARBOX__45__RXN" name="Uroporphyrinogen decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Urod )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen decarboxylase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.37</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYM__45__PHOSPH__45__RXN" name="Thymidine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tymp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine phosphorylase )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="THYMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__13" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: Vitamin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__329" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__56__45__RXN" name="Inositol-1,4,5-trisphosphate 5-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Inpp5a ) or ( Pps ) or ( Inpp5f ) or ( Inpp5b ) or ( Inpp5d ) or ( Pib5pa ) or ( Inpp5e )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate-5-phosphatase A ) or ( putative phosphatase ) or ( inositol polyphosphate-5-phosphatase F ) or ( inositol polyphosphate-5-phosphatase B ) or ( inositol polyphosphate-5-phosphatase D ) or ( phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A ) or ( inositol polyphosphate-5-phosphatase E )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLY3KIN__45__RXN" name="Glycerate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Glyctk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.31</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7952" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lipe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipase, hormone sensitive )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.79</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Monoacylglycerols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nme3 ) or ( Nme1 ) or ( Nme4 ) or ( Nme2 ) or ( Rp2h ) or ( Nme5 ) or ( Nme7 ) or ( Nme6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( non-metastatic cells 3, protein expressed in ) or ( non-metastatic cells 1, protein (NM23A) expressed in ) or ( non-metastatic cells 4, protein expressed in ) or ( non-metastatic cells 2, protein (NM23B) expressed in ) or ( retinitis pigmentosa 2 homolog (human) ) or ( non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) ) or ( non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) ) or ( non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6425" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6123" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6122" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Adh1 ) or ( Adh4 ) or ( Adh7 ) or ( Adh5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase 1 (class I) ) or ( alcohol dehydrogenase 4 (class II), pi polypeptide ) or ( alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ) or ( alcohol dehydrogenase 5 (class III), chi polypeptide )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7954" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( 4631426J05Rik )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RIKEN cDNA 4631426J05 gene )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.33</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHONDROITIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHONDROITIN__45__6__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6424" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6121" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6123" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLESTENONE__45__5__45__BETA__45__REDUCTASE__45__RXN" name="Cholestenone 5-&amp;beta;-reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1d1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1, member D1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1082" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__323" stoichiometry="1"/>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6423" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6124" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6421" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Smox ) or ( Paox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermine oxidase ) or ( polyamine oxidase (exo-N4-amino) )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.11</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
      <speciesReference species="CPD__45__6121" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDATE__45__PHOSPHATASE__45__RXN" name="Phosphatidate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ppap2b ) or ( Ppap2a ) or ( D3Bwg0562e ) or ( BC005764 ) or ( Ppap2c )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidic acid phosphatase type 2B ) or ( phosphatidic acid phosphatase 2a ) or ( DNA segment, Chr 3, Brigham &amp; Women&apos;s Genetics 0562 expressed ) or ( cDNA sequence BC005764 ) or ( phosphatidic acid phosphatase type 2c )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7950" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lipe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipase, hormone sensitive )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.79</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Monoacylglycerols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7951" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lipe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipase, hormone sensitive )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.79</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="__124__Diacylglycerides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__318" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nsdhl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P) dependent steroid dehydrogenase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4702" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4581" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__317" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4580" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4702" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__319" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxysteroid (17-beta) dehydrogenase 7 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4581" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPYRIMIDINASE__45__RXN" name="Dihydropyrimidinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dpys )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydropyrimidinase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__314" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxysteroid (17-beta) dehydrogenase 7 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4578" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__METHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__10__46__2__46__2__45__RXN" name="Ubiquinol--cytochrome c reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Uqcrc2 ) or ( Uqcrb ) or ( Uqcrfs1 ) or ( Uqcrc1 ) or ( Uqcrq ) or ( Uqcrh ) or ( 1110020P15Rik ) or ( Uqcr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ubiquinol cytochrome c reductase core protein 2 ) or ( ubiquinol-cytochrome c reductase binding protein ) or ( ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 ) or ( ubiquinol-cytochrome c reductase core protein 1 ) or ( ubiquinol-cytochrome c reductase, complex III subunit VII ) or ( ubiquinol-cytochrome c reductase hinge protein ) or ( RIKEN cDNA 1110020P15 gene ) or ( ubiquinol-cytochrome c reductase (6.4kD) subunit )</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donor II</html:p>
<html:p>PROTEIN_CLASS: 1.10.2.2</html:p>
<html:p>COFACTOR: __124__Ubiquinols__124__</html:p>
<html:p>COFACTOR: __124__Ubiquinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2361" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2363" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__313" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nsdhl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P) dependent steroid dehydrogenase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4577" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4578" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__316" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4579" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4580" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__32__45__RXN" name="Phosphoenolpyruvate carboxykinase (GTP)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pck2 ) or ( Pck1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoenolpyruvate carboxykinase 2 (mitochondrial) ) or ( phosphoenolpyruvate carboxykinase 1, cytosolic )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.32</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__315" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__METHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4579" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INDOLEAMINE__45__PYRROLE__45__23__45__DIOXYGENASE__45__RXN" name="Indoleamine-pyrrole 2,3-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Indo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indoleamine-pyrrole 2,3 dioxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.42</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMYLKYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Carnitine O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Crat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.7</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__ACETYLCARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__42__45__RXN" name="Glycerone-phosphate O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gnpat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyceronephosphate O-acyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.42</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__415" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGINASE__45__RXN" name="Arginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Arg2 ) or ( Arg1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase type II ) or ( arginase 1, liver )</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation (arginase pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_11__45__BETA__45__HYDROXYSTEROID__45__DEHYDROGENASE__45__RXN" name="11-&amp;beta;-hydroxysteroid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd11b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxysteroid 11-beta dehydrogenase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.146</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__11__45__Beta__45__Hydroxysteroids1__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__11__45__Oxosteroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLATECYC__45__RXN" name="Adenylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Adcy1 ) or ( Adcy3 ) or ( Adcy4 ) or ( Adcy10 ) or ( Adcy7 ) or ( Adcyap1r1 ) or ( Adcy6 ) or ( Adcy5 ) or ( Adcy8 ) or ( Adcy2 ) or ( Adcy9 ) or ( Adcyap1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylate cyclase 1 ) or ( adenylate cyclase 3 ) or ( adenylate cyclase 4 ) or ( adenylate cyclase 10 ) or ( adenylate cyclase 7 ) or ( adenylate cyclase activating polypeptide 1 receptor 1 ) or ( adenylate cyclase 6 ) or ( adenylate cyclase 5 ) or ( adenylate cyclase 8 ) or ( adenylate cyclase 2 ) or ( adenylate cyclase 9 ) or ( adenylate cyclase activating polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__22" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp17a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 17, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of estrogens</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREGNENOLONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_17__45__ALPHA20__45__ALPHA__45__DIHYDROXYPREGN__45__4__45__EN__45__3__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__23" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp17a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 17, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of androgens</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREGNENOLONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3DJ__45__19" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__310" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4575" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__311" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4575" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4576" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__312" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4576" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4577" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8655" name="Lipoate--protein ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Prps1l1 ) or ( Prps2 ) or ( Prps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosyl pyrophosphate synthetase 1-like 1 ) or ( phosphoribosyl pyrophosphate synthetase 2 ) or ( phosphoribosyl pyrophosphate synthetase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.63</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
      <speciesReference species="LIPOYL__45__AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__6__45__N__45__lipoyl__45__lysine__124__" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8654" name="Lipoate--protein ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Prps1l1 ) or ( Prps2 ) or ( Prps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosyl pyrophosphate synthetase 1-like 1 ) or ( phosphoribosyl pyrophosphate synthetase 2 ) or ( phosphoribosyl pyrophosphate synthetase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.63</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LIPOIC__45__ACID" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOYL__45__AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__1__45__RXN" name="&amp;beta;-galactosamide &amp;alpha;-2,6-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( St6gal1 ) or ( St6gal2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta galactoside alpha 2,6 sialyltransferase 1 ) or ( beta galactoside alpha 2,6 sialyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.1</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__26__45__BETA__45__D__45__GALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIB5PISOM__45__RXN" name="Ribose 5-phosphate epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Rpia )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose 5-phosphate isomerase A )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: non-oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__26" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp19a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 19, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of estrogens</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ANDROST4ENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3DJ__45__5" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IPPISOM__45__RXN" name="Isopentenyl-diphosphate &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nudt12 ) or ( Idi2 ) or ( Idi1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nudix (nucleoside diphosphate linked moiety X)-type motif 12 ) or ( isopentenyl-diphosphate delta isomerase 2 ) or ( isopentenyl-diphosphate delta isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDINE__45__AMMONIA__45__LYASE__45__RXN" name="Histidine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hal )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidine ammonia lyase )</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.3</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROCANATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_15__45__OXOPROSTAGLANDIN__45__13__45__REDUCTASE__45__RXN" name="15-oxoprostaglandin 13-reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ptgr1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostaglandin reductase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.48</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__HYDROXY__45__915__45__DIOXOPROSTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXY__45__915__45__DIOXOPROSTA__45__13__45__ENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__212__45__RXN" name="Hyaluronan synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Has2 ) or ( Has3 ) or ( Has1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hyaluronan synthase 2 ) or ( hyaluronan synthase 3 ) or ( hyaluronan synthase1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.212</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__beta__45__N__45__acetyl__45__D__45__glucosaminyl__40__1__45____62__4__41__beta__45__D__45__glucuronosyl__40__1__45____62__3__41____93____40__n__41____43____32__2n__32__UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__32" name="3-&amp;beta;-hydroxy-&amp;delta;(5)-steroid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd3b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of estrogens</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.145</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_17__45__ALPHA20__45__ALPHA__45__DIHYDROXYPREGN__45__4__45__EN__45__3__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_17__45__ALPHA__45__HYDROXYPROGESTERONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__15__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mthfd2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.15</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__35" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Rgn )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( regucalcin )</html:p>
<html:p>SUBSYSTEM: Vitamin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GULONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__34" name="3-&amp;beta;-hydroxy-&amp;delta;(5)-steroid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd3b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of androgens</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.145</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3DJ__45__19" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_17__45__ALPHA__45__HYDROXYPROGESTERONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPOXANPRIBOSYLTRAN__45__RXN" name="Hypoxanthine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hprt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine guanine phosphoribosyl transferase 1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__322" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc5d )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1064" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__DEHYDRO__45__CHOLESTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__323" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhcr7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_7__45__DEHYDRO__45__CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__320" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ebp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylalkylamine Ca2+ antagonist (emopamil) binding protein )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhcr24 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 24-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.72</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1064" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pla2g6 ) or ( Pla2g5 ) or ( Pla2g2a ) or ( Pla2g2c ) or ( Pla2g4f ) or ( Pla2g12b ) or ( Pla2g1b ) or ( Pla2g4a ) or ( Pla2g4d ) or ( Pla2g12a ) or ( Pla2g2f ) or ( Pla2g4e ) or ( Pla2g2e ) or ( Pla2g4b ) or ( Pla2g2d ) or ( Pla2g10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase A2, group VI ) or ( phospholipase A2, group V ) or ( phospholipase A2, group IIA (platelets, synovial fluid) ) or ( phospholipase A2, group IIC ) or ( phospholipase A2, group IVF ) or ( phospholipase A2, group XIIB ) or ( phospholipase A2, group IB, pancreas ) or ( phospholipase A2, group IVA (cytosolic, calcium-dependent) ) or ( phospholipase A2, group IVD ) or ( phospholipase A2, group XIIA ) or ( phospholipase A2, group IIF ) or ( phospholipase A2, group IVE ) or ( phospholipase A2, group IIE ) or ( phospholipase A2, group IVB (cytosolic) ) or ( phospholipase A2, group IID ) or ( phospholipase A2, group X )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LINOLENIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONDEHYDROG__45__RXN" name="Phosphogluconate dehydrogenase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphogluconate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__133__45__RXN" name="1D-myo-inositol-trisphosphate 6-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Itpk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol 1,3,4-triphosphate 5/6 kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.134</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__505" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LEUKOTRIENE__45__C4__45__SYNTHASE__45__RXN" name="Leukotriene-C4 synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ltc4s )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( leukotriene C4 synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="LEUKOTRIENE__45__A4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LEUKOTRIENE__45__C4" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOACYLASE__45__RXN" name="Aminoacylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Acy1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminoacylase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.14</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Acylated__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Amino__45__Acid__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__35519" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Shmt2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__N6N6N6__45__TRIMETHYL__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="_4__45__TRIMETHYLAMMONIOBUTANAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7706" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adh1 ) or ( Adh4 ) or ( D3Nds9 ) or ( Adh7 ) or ( Adh6b ) or ( Adh5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase 1 (class I) ) or ( alcohol dehydrogenase 4 (class II), pi polypeptide ) or ( DNA segment, Chr 3, Nuffield Department of Surgery 9 ) or ( alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ) or ( alcohol dehydrogenase 6B (class V) ) or ( alcohol dehydrogenase 5 (class III), chi polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7036" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7037" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANINE__45__DEAMINASE__45__RXN" name="Guanine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gda )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine deaminase )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINE__45__OXIDASE__45__FLAVIN__45__CONTAINING__45__RXN" name="Amine oxidase (flavin-containing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Maoa ) or ( Aof1 ) or ( Maob )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monoamine oxidase A ) or ( amine oxidase, flavin containing 1 ) or ( amine oxidase activity )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYL__45__KIN__45__RXN" name="Guanylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mpp5 ) or ( Guk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) ) or ( guanylate kinase 1 )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Trmt11 ) or ( Hemk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA methyltransferase 11 homolog (S. cerevisiae) ) or ( HemK methyltransferase family member 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6142" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7700" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adh1 ) or ( Adh4 ) or ( D3Nds9 ) or ( Adh7 ) or ( Adh6b ) or ( Adh5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase 1 (class I) ) or ( alcohol dehydrogenase 4 (class II), pi polypeptide ) or ( DNA segment, Chr 3, Nuffield Department of Surgery 9 ) or ( alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ) or ( alcohol dehydrogenase 6B (class V) ) or ( alcohol dehydrogenase 5 (class III), chi polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7035" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Trmt11 ) or ( Hemk1 ) or ( Inmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA methyltransferase 11 homolog (S. cerevisiae) ) or ( HemK methyltransferase family member 1 ) or ( indolethylamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.49</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6141" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__154__45__RXN" name="Phosphatidylinositol-4-phosphate 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pik3r3 ) or ( Pik3r2 ) or ( Centg1 ) or ( Pik3ip1 ) or ( Pik3c2a ) or ( Pik3r5 ) or ( Pik3c2g ) or ( Pik3r6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) ) or ( phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) ) or ( centaurin, gamma 1 ) or ( phosphoinositide-3-kinase interacting protein 1 ) or ( phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide ) or ( phosphoinositide-3-kinase, regulatory subunit 5, p101 ) or ( phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide ) or ( phosphoinositide-3-kinase, regulatory subunit 6 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.154</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__1D__45__MYO__45__INOSITOL__45__34__45__BISPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URATE__45__OXIDASE__45__RXN" name="Urate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Uox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( urate oxidase )</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: urate degradation to allantoin</html:p>
<html:p>PROTEIN_CLASS: 1.7.3.3</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__HYDROXYISOURATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__2__46__31__45__RXN" name="NAD(P)(+)--arginine ADP-ribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Art4 ) or ( Sirt6 ) or ( Art3 ) or ( Art2a ) or ( Art2b ) or ( Art1 ) or ( Art5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-ribosyltransferase 4 ) or ( sirtuin 6 (silent mating type information regulation 2, homolog) 6 (S. cerevisiae) ) or ( ADP-ribosyltransferase 3 ) or ( ADP-ribosyltransferase 2a ) or ( ADP-ribosyltransferase 2b ) or ( ADP-ribosyltransferase 1 ) or ( ADP-ribosyltransferase 5 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.31</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__557" stoichiometry="1"/>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7908" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pcbd2 ) or ( Pcbd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 ) or ( pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I</html:p>
<html:p>SUBSYSTEM: Biopterin recycling</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.96</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOTIDE__45__PYROPHOSPHATASE__45__RXN" name="Nucleotide pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Enpp5 ) or ( Enpp3 ) or ( Enpp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleotide pyrophosphatase/phosphodiesterase 5 ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 3 ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.9</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__32__DINUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MONONUCLEOTIDE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__9__46__3__45__RXN" name="Selenide,water dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sephs1 ) or ( Sephs2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( selenophosphate synthetase 1 ) or ( selenophosphate synthetase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__678" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SEPO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__46" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd3b6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of estrogens</html:p>
<html:p>SUBSYSTEM: biosynthesis of androgens</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.30</html:p>
<html:p>SIDE: ACETALD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_17__45__ALPHA__45__HYDROXYPROGESTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="ANDROST4ENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__145__45__RXN" name="3-&amp;beta;-hydroxy-&amp;delta;(5)-steroid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd3b6 ) or ( Hsd3b1 ) or ( Hsd3b5 ) or ( Hsd3b2 ) or ( Hsd3b7 ) or ( Hsd3b3 ) or ( Hsd3b4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.145</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3b__45__hydroxy__45__D5__45__steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__oxo__45__D5__45__steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__PHOSPHOFRUCTO__45__2__45__KINASE__45__RXN" name="6-phosphofructo-2-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pfkfb2 ) or ( Pfkfb1 ) or ( Pfkfb4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.105</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__535" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__20__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gnmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.20</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CORTICOSTEROID__45__SIDE__45__CHAIN__45__ISOMERASE__45__RXN" name="Corticosteroid side-chain-isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Csi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( corticosteroid side chain isomerase activity )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_11__45__DEOXYCORTICOSTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_20__45__HYDROXY__45__3__45__OXOPREGN__45__4__45__EN__45__21__45__AL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nme3 ) or ( Nme1 ) or ( Nme4 ) or ( Nme2 ) or ( Rp2h ) or ( Nme5 ) or ( Nme7 ) or ( Nme6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( non-metastatic cells 3, protein expressed in ) or ( non-metastatic cells 1, protein (NM23A) expressed in ) or ( non-metastatic cells 4, protein expressed in ) or ( non-metastatic cells 2, protein (NM23B) expressed in ) or ( retinitis pigmentosa 2 homolog (human) ) or ( non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) ) or ( non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) ) or ( non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMACETOXID__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Maob ) or ( Aoc3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amine oxidase activity ) or ( amine oxidase, copper containing 3 )</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__35528" name="Aralkylamine N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aanat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aralkylamine N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: biosynthesis of serotonin and melatonin</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.87</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SEROTONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__SEROTONIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__C__45__PALMITOYLTRANSFERASE__45__RXN" name="Serine C-palmitoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sptlc2 ) or ( Sptlc3 ) or ( Sptlc1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine palmitoyltransferase, long chain base subunit 2 ) or ( serine palmitoyltransferase, long chain base subunit 3 ) or ( serine palmitoyltransferase, long chain base subunit 1 )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.50</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PALMITYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PALMITYL__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROSPHINGANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTASE__45__RXN" name="Lactase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lct )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lactase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.108</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7710" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gbe1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucan (1,4-alpha-), branching enzyme 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7711" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pecr ) or ( Mecr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal trans-2-enoyl-CoA reductase ) or ( mitochondrial trans-2-enoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYRAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__2__46__23__45__RXN" name="Heparin-glucosamine 3-O-sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hs3st3a1 ) or ( Hs3st1 ) or ( Hs3st5 ) or ( Hs3st4 ) or ( Hs3st6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 ) or ( heparan sulfate (glucosamine) 3-O-sulfotransferase 1 ) or ( heparan sulfate (glucosamine) 3-O-sulfotransferase 5 ) or ( heparan sulfate (glucosamine) 3-O-sulfotransferase 4 ) or ( heparan sulfate (glucosamine) 3-O-sulfotransferase 6 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.23</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HEPARIN__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEPARIN__45__GLUCOSAMINE__45__3__45__O__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7911" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Decr2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRADEHYDROACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Glycine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gnmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.156</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RETINOL__45__DEHYDROGENASE__45__RXN" name="Retinol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Rdh1 ) or ( Rdh16 ) or ( Rdh9 ) or ( Rdh7 ) or ( Rdh5 ) or ( Rdh19 ) or ( Rdh8 ) or ( Hsd17b6 ) or ( Rdh2 ) or ( Rdh10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( retinol dehydrogenase 1 (all trans) ) or ( retinol dehydrogenase 16 ) or ( retinol dehydrogenase 9 ) or ( retinol dehydrogenase 7 ) or ( retinol dehydrogenase 5 ) or ( retinol dehydrogenase 19 ) or ( retinol dehydrogenase 8 ) or ( hydroxysteroid (17-beta) dehydrogenase 6 ) or ( retinol dehydrogenase 2 ) or ( retinol dehydrogenase 10 (all-trans) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.105</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RETINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RETINAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6464" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Trmt11 ) or ( Hemk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA methyltransferase 11 homolog (S. cerevisiae) ) or ( HemK methyltransferase family member 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6142" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6181" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__19__45__RXN" name="Nucleoside-triphosphate pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Itpa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine triphosphatase (nucleoside triphosphate pyrophosphatase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7919" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hagh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacyl glutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__hydroxyacyl__45__glutathiones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Hydroxy__45__carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__56" name="Testosterone 17-&amp;beta;-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxysteroid (17-beta) dehydrogenase 3 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of androgens</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.64</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ANDROST4ENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TESTOSTERONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__75__45__RXN" name="Long-chain-alcohol O-fatty-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dgat2l3 ) or ( Dgat2l4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diacylglycerol O-acyltransferase 2-like 3 ) or ( diacylglycerol O-acyltransferase 2-like 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.75</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__a__45__long__45__chain__45__alcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__32__LONG__45__CHAIN__32__ESTER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETHYLBILANESYN__45__RXN" name="Hydroxymethylbilane synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hmbs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxymethylbilane synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.61</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DURIDKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tk2 ) or ( Tk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine kinase 2, mitochondrial ) or ( thymidine kinase 1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BISPHOSPHOGLYCERATE__45__MUTASE__45__RXN" name="Bisphosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Bpgm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-bisphosphoglycerate mutase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_23__45__DIPHOSPHOGLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__METHYLACYL__45__COA__45__DEHYDROGENASE__45__RXN" name="2-methylacyl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Acadsb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-Coenzyme A dehydrogenase, short/branched chain )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.12</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__METHYL__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLCROTONYL__45__COA__45__CARBOXYLASE__45__RXN" name="Methylcrotonyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mccc2 ) or ( Mccc1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylcrotonoyl-Coenzyme A carboxylase 2 (beta) ) or ( methylcrotonoyl-Coenzyme A carboxylase 1 (alpha) )</html:p>
<html:p>SUBSYSTEM: leucine degradation</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PFRUCTPHOS__45__RXN" name="6-phosphofructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pfkp ) or ( Pfkl ) or ( Pfkm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphofructokinase, platelet ) or ( phosphofructokinase, liver, B-type ) or ( phosphofructokinase, muscle )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__142__45__RXN" name="Chitobiosyldiphosphodolichol &amp;alpha;-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Alg1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.142</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NN__45__DIACETYLCHITOBIOSYLDIPHOSPHODOLICHO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__MANNOSYLCHITOBIO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__150__45__RXN" name="N-acetyllactosaminide &amp;beta;-1,6-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gcnt2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosaminyl (N-acetyl) transferase 2, I-branching enzyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.150</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__16__45__ETCETERA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINOALANINE__45__AMINOTRANSFERASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Got1 ) or ( Got2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate oxaloacetate transaminase 1, soluble ) or ( glutamate oxaloacetate transaminase 2, mitochondrial )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.1</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSCHOL__45__RXN" name="Phospholipase D" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pld4 ) or ( Pld2 ) or ( Pld1 ) or ( Pld3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase D family, member 4 ) or ( phospholipase D2 ) or ( phospholipase D1 ) or ( phospholipase D family, member 3 )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOTHENATE__45__KIN__45__RXN" name="Pantothenate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pank4 ) or ( Pank2 ) or ( Pank1 ) or ( Pank3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantothenate kinase 4 ) or ( pantothenate kinase 2 (Hallervorden-Spatz syndrome) ) or ( pantothenate kinase 1 ) or ( pantothenate kinase 3 )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHINE__45__OXIDASE__45__RXN" name="Xanthine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Xdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__95__45__RXN" name="7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp8b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 8, subfamily b, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.95</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1087" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7237" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGEN__45__BRANCH__45__RXN" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gbe1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucan (1,4-alpha-), branching enzyme 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENODEAMIN__45__RXN" name="Adenosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adad1 ) or ( Adarb1 ) or ( Ada ) or ( Adad2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine deaminase domain containing 1 (testis specific) ) or ( adenosine deaminase, RNA-specific, B1 ) or ( adenosine deaminase ) or ( adenosine deaminase domain containing 2 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ESTRONE__45__SULFOTRANSFERASE__45__RXN" name="Estrone sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sult1e1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfotransferase family 1E, member 1 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of estrogens</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.4</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>SIDE: PAP</html:p>
<html:p>SIDE: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ESTRONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ESTRONE__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINEOXID__45__RXN" name="Amine oxidase (copper-containing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Abp1 ) or ( Aoc2 ) or ( Aoc3 ) or ( Aoc3-rs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amiloride binding protein 1 (amine oxidase, copper-containing) ) or ( amine oxidase, copper containing 2 (retina-specific) ) or ( amine oxidase, copper containing 3 ) or ( amine oxidase, copper containing 3, related sequence )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNA__45__RXN" name="Aspartate--ammonia ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Asnsd1 ) or ( Asns )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine synthetase domain containing 1 ) or ( asparagine synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__270__45__RXN" name="3-keto-steroid reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxysteroid (17-beta) dehydrogenase 7 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__ALPHA__45__METHYL__45__5__45__ALPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__ALPHA__45__METHYL__45__5__45__ALPHA__45__CHOLEST__45__7__45__EN__45__3__45__ON" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYLPHOSPHATASE__45__RXN" name="Aryldialkylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pon1 ) or ( Pon2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( paraoxonase 1 ) or ( paraoxonase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Dialkyl__45__Phosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIALKYL__32__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5581" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh1a3 ) or ( Aldh3b1 ) or ( Aldh3a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family 1, subfamily A3 ) or ( aldehyde dehydrogenase 3 family, member B1 ) or ( aldehyde dehydrogenase family 3, subfamily A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE__45__CARBOXYLASE__45__RXN" name="Pyruvate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pcx )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate carboxylase )</html:p>
<html:p>SUBSYSTEM: aspartate biosynthesis</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__LACTAMASE__45__RXN" name="&amp;beta;-lactamase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lactb ) or ( Lactb2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lactamase, beta ) or ( lactamase, beta 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__Lactams__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__32__SUBSTITUTED__32__BETA__45__AMINO__32__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNI__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Oxct2a ) or ( Oxct1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxoacid CoA transferase 2A ) or ( 3-oxoacid CoA transferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__99__46__4__45__RXN" name="&amp;alpha;-methylacyl-CoA racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Amacr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-methylacyl-CoA racemase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__2__45__METHYLACYL__45__COA" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__2__45__METHYLACYL__45__COA" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="R542__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adh1 ) or ( Adh4 ) or ( D3Nds9 ) or ( Adh7 ) or ( Adh6b ) or ( Adh5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase 1 (class I) ) or ( alcohol dehydrogenase 4 (class II), pi polypeptide ) or ( DNA segment, Chr 3, Nuffield Department of Surgery 9 ) or ( alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ) or ( alcohol dehydrogenase 6B (class V) ) or ( alcohol dehydrogenase 5 (class III), chi polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__863" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__864" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__45__45__RXN" name="Aminocarboxymuconate-semialdehyde decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Acmsd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amino carboxymuconate semialdehyde decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__3__45__OXOPROP__45__2__45__ENYL__45__BUT__45__2__45__ENEDI" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__15__46__6__45__RXN" name="Cholesterol monooxygenase (side-chain cleaving)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp11a1 ) or ( Fdx1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 11, subfamily a, polypeptide 1 ) or ( ferredoxin 1 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of estrogens</html:p>
<html:p>SUBSYSTEM: biosynthesis of corticosteroids</html:p>
<html:p>SUBSYSTEM: biosynthesis of androgens</html:p>
<html:p>PROTEIN_CLASS: 1.14.15.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _4__45__METHYLPENTANAL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PREGNENOLONE" stoichiometry="1"/>
      <speciesReference species="_4__45__METHYLPENTANAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYCEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Diacylglycerol O-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dgat1 ) or ( Dgat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diacylglycerol O-acyltransferase 1 ) or ( diacylglycerol O-acyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.20</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEPHOSPHOCOAKIN__45__RXN" name="Dephospho-CoA kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Coasy ) or ( Dcakd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Coenzyme A synthase ) or ( dephospho-CoA kinase domain containing )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__11__46__1__46__15__45__RXN" name="Peroxiredoxin" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Prdx2-rs5 ) or ( Prdx1 ) or ( Prdx4 ) or ( Prdx1-rs5 ) or ( Prdx2 ) or ( Prdx2-rs2 ) or ( Prdx1-rs4 ) or ( Prdx2-rs3 ) or ( Prdx6-rs1 ) or ( Prdx6-rs3 ) or ( Prdx6-rs2 ) or ( Prdx1-rs3 ) or ( Prdx2-rs7 ) or ( Prdx2-rs1 ) or ( Prdx2-rs6 ) or ( Prdx2-rs4 ) or ( Prdx1-rs2 ) or ( Prdx6 ) or ( Prdx5 ) or ( Prdx3 ) or ( Prdx1-rs1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxiredoxin 2, related sequence 5 ) or ( peroxiredoxin 1 ) or ( peroxiredoxin 4 ) or ( peroxiredoxin 1, related sequence 5 ) or ( peroxiredoxin 2 ) or ( peroxiredoxin 2, related sequence 2 ) or ( peroxiredoxin 1, related sequence 4 ) or ( peroxiredoxin 2, related sequence 3 ) or ( peroxiredoxin 6, related sequence 1 ) or ( peroxiredoxin 6, related sequence 3 ) or ( peroxiredoxin 6, related sequence 2 ) or ( peroxiredoxin 1, related sequence 3 ) or ( peroxiredoxin 2, related sequence 7 ) or ( peroxiredoxin 2, related sequence 1 ) or ( peroxiredoxin 2, related sequence 6 ) or ( peroxiredoxin 2, related sequence 4 ) or ( peroxiredoxin 1, related sequence 2 ) or ( peroxiredoxin 6 ) or ( peroxiredoxin 5 ) or ( peroxiredoxin 3 ) or ( peroxiredoxin 1, related sequence 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="2"/>
      <speciesReference species="__124__Alkyl__45__Hydro__45__Peroxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__AMINO__45__ACID__45__OXIDASE__45__RXN" name="L-amino acid oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Il4i1 ) or ( Lao1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( interleukin 4 induced 1 ) or ( L-amino acid oxidase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Amino__45__Acid__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__97__45__RXN" name="Glycylpeptide N-tetradecanoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nmt1 ) or ( Nmt2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-myristoyltransferase 1 ) or ( N-myristoyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.97</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRADECANOYL__45__COA" stoichiometry="1"/>
      <speciesReference species="GLYCYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__TETRADECANOYLGLYCYL__45__PEPTIDE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__2__46__17__45__RXN" name="Hydroxyisourate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 1190003J15Rik )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RIKEN cDNA 1190003J15 gene )</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: urate degradation to allantoin</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__HYDROXYISOURATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5821" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULP3EPIM__45__RXN" name="ribulose phosphate 3-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Rpe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribulose-5-phosphate-3-epimerase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: non-oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOSE__45__SYNTHASE__45__RXN" name="Lactose synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B4galt2 ) or ( B4galt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 ) or ( UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__5__46__1__45__RXN" name="Nitrilase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nit1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrilase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nitriles__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINKIN__45__RXN" name="Riboflavin kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Rfk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( riboflavin kinase )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD transformations</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__141__45__RXN" name="N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Alg13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine-linked glycosylation 13 homolog (S. cerevisiae) )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.141</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__190" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NN__45__DIACETYLCHITOBIOSYLDIPHOSPHODOLICHO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCHORMAT__45__RXN" name="Isochorismatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Isoc1 ) or ( Isoc2a ) or ( Isoc2b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isochorismatase domain containing 1 ) or ( isochorismatase domain containing 2a ) or ( isochorismatase domain containing 2b )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOCHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRO__45__DIOH__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOHEXOKINASE__45__RXN" name="Ketohexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Khk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ketohexokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__2__46__29__45__RXN" name="[Heparan sulfate]-glucosamine 3-sulfotransferase 2" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hs3st2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heparan sulfate (glucosamine) 3-O-sulfotransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.29</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__heparan__32__sulfate__93____45__glucosamine" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__heparan__32__sulfate__93____45__glucosamine__32__3__45__sulfate" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEHYDR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aco2 ) or ( Aco1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitase 2, mitochondrial ) or ( aconitase 1 )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDDEHYDROG__45__RXN" name="Lactaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh5 ) or ( Aldh1a3 ) or ( Aldh2 ) or ( Aldh9a1 ) or ( Aldh3b1 ) or ( Aldh3a2 ) or ( Aldh7a1 ) or ( Aldh3a1 ) or ( Aldh1b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 5, testis ) or ( aldehyde dehydrogenase family 1, subfamily A3 ) or ( aldehyde dehydrogenase 2, mitochondrial ) or ( aldehyde dehydrogenase 9, subfamily A1 ) or ( aldehyde dehydrogenase 3 family, member B1 ) or ( aldehyde dehydrogenase family 3, subfamily A2 ) or ( aldehyde dehydrogenase family 7, member A1 ) or ( aldehyde dehydrogenase family 3, subfamily A1 ) or ( aldehyde dehydrogenase 1 family, member B1 )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-D-GLUCOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__XYLULOSE__45__REDUCTASE__45__RXN" name="L-xylulose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dcxr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dicarbonyl L-xylulose reductase )</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation II</html:p>
<html:p>SUBSYSTEM: glucuronate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.10</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5114" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Psph )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine phosphatase )</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDINE__45__DECARBOXYLASE__45__RXN" name="Histidine decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hdc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidine decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__1__46__8__45__RXN" name="Lipoyl synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lias )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipoic acid synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
      <speciesReference species="S8" stoichiometry="2"/>
      <speciesReference species="__124__Protein__45__6__45__N__45__octanoyl__45__lysine__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="MET" stoichiometry="2"/>
      <speciesReference species="__124__Protein__45__6__45__N__45__lipoyl__45__lysine__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R223__45__RXN" name="long-chain-fatty-acid-CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acsl4 ) or ( Slc27a5 ) or ( Acsbg1 ) or ( Acsl5 ) or ( Acsl3 ) or ( Acsl6 ) or ( Slc27a6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA synthetase long-chain family member 4 ) or ( solute carrier family 27 (fatty acid transporter), member 5 ) or ( acyl-CoA synthetase bubblegum family member 1 ) or ( acyl-CoA synthetase long-chain family member 5 ) or ( acyl-CoA synthetase long-chain family member 3 ) or ( acyl-CoA synthetase long-chain family member 6 ) or ( solute carrier family 27 (fatty acid transporter), member 6 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTANOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXKIN__45__RXN" name="Pyridoxal kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pdxk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal (pyridoxine, vitamin B6) kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPPSYN__45__RXN" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdps ) or ( Fntb ) or ( Ggps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl diphosphate synthetase ) or ( farnesyltransferase, CAAX box, beta ) or ( geranylgeranyl diphosphate synthase 1 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNCARBAMTRANSFER__45__RXN" name="Ornithine carbamoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Otc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine transcarbamylase )</html:p>
<html:p>SUBSYSTEM: citrulline degradation</html:p>
<html:p>SUBSYSTEM: proline biosynthesis V (from arginine)</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__FORMYL__45__THF__45__CYCLO__45__LIGASE__45__RXN" name="5-formyltetrahydrofolate cyclo-ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mthfs ) or ( Mthfsd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5, 10-methenyltetrahydrofolate synthetase ) or ( methenyltetrahydrofolate synthetase domain containing )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNKIN__45__RXN" name="Mannokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hk3 ) or ( Hkdc1 ) or ( Hk1 ) or ( Hk2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase 3 ) or ( hexokinase domain containing 1 ) or ( hexokinase 1 ) or ( hexokinase 2 )</html:p>
<html:p>SUBSYSTEM: mannose degradation</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__5__45__MONOOXYGENASE__45__RXN" name="Tryptophan 5-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tph1 ) or ( Tph2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan hydroxylase 1 ) or ( tryptophan hydroxylase 2 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of serotonin and melatonin</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__5881</html:p>
<html:p>SIDE: TETRA__45__H__45__BIOPTERIN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
      <speciesReference species="_5__45__HYDROXY__45__TRYPTOPHAN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8489" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tyr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8671" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8672" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINSYN__45__RXN" name="argininosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ass1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate synthetase 1 )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8488" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tyr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8670" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8671" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__2__46__25__45__RXN" name="Tubulin--tyrosine ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ttl ) or ( Ttll8 ) or ( Ttll13 ) or ( Ttll1 ) or ( Ttll4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tubulin tyrosine ligase ) or ( tubulin tyrosine ligase-like family, member 8 ) or ( tubulin tyrosine ligase-like family, member 13 ) or ( tubulin tyrosine ligase-like 1 ) or ( tubulin tyrosine ligase-like family, member 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.25</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="__91__ALPHA__45__TUBULIN__93__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__TYROSYL__45____91__ALPHA__45__TUBULIN__93__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__300" name="Glyoxylate reductase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Grhpr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxylate reductase/hydroxypyruvate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnp1 ) or ( Pnp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase 1 ) or ( purine-nucleoside phosphorylase 2 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMETB12__45__RXN" name="5-methyltetrahydrofolate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mtr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-methyltetrahydrofolate-homocysteine methyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOPURINE__45__S__45__METHYLTRANSFERASE__45__RXN" name="Thiopurine S-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tpmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiopurine methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.67</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Thiopurines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Thiopurine__45__Methylethers__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nfs1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrogen fixation gene 1 (S. cerevisiae) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="PROTEIN__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ENZYME__45__S__45__SULFANYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATASE__45__RXN" name="Glucose-6-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( G6pc2 ) or ( G6pc ) or ( G6pc3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphatase, catalytic, 2 ) or ( glucose-6-phosphatase, catalytic ) or ( glucose 6 phosphatase, catalytic, 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KYNURENINE__45__3__45__MONOOXYGENASE__45__RXN" name="Kynurenine 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Kmo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.9</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__305" name="Hydroxypyruvate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hyi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxypyruvate isomerase homolog (E. coli) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDINEKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Uck2 ) or ( Uck1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine-cytidine kinase 2 ) or ( uridine-cytidine kinase 1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOVALERYL__45__COA__45__FAD__45__RXN" name="Isovaleryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ivd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isovaleryl coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: leucine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FADSYN__45__RXN" name="FMN adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Flad1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RFad1, flavin adenine dinucleotide synthetase, homolog (yeast) )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD transformations</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.2</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8092" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnp1 ) or ( Pnp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase 1 ) or ( purine-nucleoside phosphorylase 2 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxybutyrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Bdh2 ) or ( Bdh1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyrate dehydrogenase, type 2 ) or ( 3-hydroxybutyrate dehydrogenase, type 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.30</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__335" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__97__46__1__46__11__45__RXN" name="Thyroxine 5-deiodinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dio3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deiodinase, iodothyronine type III )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.11</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__387" stoichiometry="1"/>
      <speciesReference species="LIOTHYRONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__THYROXINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTAMINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Histamine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hnmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.8</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__METHYL__45__HISTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYLGLUCOSAMINE__45__4__45__EPIMERASE__45__RXN" name="UDP-N-acetylglucosamine 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gale )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactose-4-epimerase, UDP )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROCOLLAGEN__45__LYSINE__45__5__45__DIOXYGENASE__45__RXN" name="Procollagen-lysine 5-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Plod2 ) or ( Plod1 ) or ( Plod3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 ) or ( procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 ) or ( procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.4</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROCOLLAGEN__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROCOLLAGEN__45__5__45__HYDROXY__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8853" name="Sepiapterin reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Spr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sepiapterin reductase )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.153</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8854" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Spr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sepiapterin reductase )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__LACTOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPDEPHOS__45__RXN" name="Pyruvate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pkm2 ) or ( Pklr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate kinase, muscle ) or ( pyruvate kinase liver and red blood cell )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.40</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adsl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBDEHYDROG__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh4a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 4 family, member A1 )</html:p>
<html:p>SUBSYSTEM: proline degradation III</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTEINE__45__S__45__CONJUGATE__45__BETA__45__LYASE__45__RXN" name="Cysteine-S-conjugate &amp;beta;-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ccbl1 ) or ( Ccbl2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine conjugate-beta lyase 1 ) or ( cysteine conjugate-beta lyase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__Substituted__45__L__45__Cysteines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Thiols__124__" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8647" name="Arachidonate 5-lipoxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Alox5 ) or ( Alox5ap )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 5-lipoxygenase ) or ( arachidonate 5-lipoxygenase activating protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.34</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6E8Z11Z14Z__45__5S__45__5__45__HYDROPEROXYCOSA__45__6" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8892" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOPORGENOXI__45__RXN" name="Protoporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ppox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoporphyrinogen oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__43__45__RXN" name="[Pyruvate dehydrogenase (lipoamide)]-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ppm2c )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein phosphatase 2C, magnesium dependent, catalytic subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.43</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__PYRUVATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93____32__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__PYRUVATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8645" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( L2hgdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-2-hydroxyglutarate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.2</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXYGLUTARIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLU6PDEHYDROG__45__RXN" name="Glucose-6-phosphate 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( G6pd2 ) or ( G6pdx ) or ( H6pd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate dehydrogenase 2 ) or ( glucose-6-phosphate dehydrogenase X-linked ) or ( hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.49</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NANK__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gne )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine )</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine , N-acetylmannosamine and N-acetylneuraminic acid dissimilation</html:p>
<html:p>PROTEIN_CLASS: 2.7.-.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8642" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Idh1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate dehydrogenase 1 (NADP+), soluble )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSDECARB__45__RXN" name="Phosphopantothenoylcysteine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ppcdc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphopantothenoylcysteine decarboxylase )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.36</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UMPKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cmpk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine monophosphate (UMP-CMP) kinase 1 )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__81" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fmo4 ) or ( Fmo3 ) or ( Fmo5 ) or ( Fmo6 ) or ( Fmo1 ) or ( Fmo2 ) or ( Fmo9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavin containing monooxygenase 4 ) or ( flavin containing monooxygenase 3 ) or ( flavin containing monooxygenase 5 ) or ( flavin containing monooxygenase 6 ) or ( flavin containing monooxygenase 1 ) or ( flavin containing monooxygenase 2 ) or ( flavin containing monooxygenase 9 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2743" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__82" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Inmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indolethylamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.49</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3183" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FGAMSYN__45__RXN" name="phosphoribosylformylglycinamidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pfas )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARACHIDONATE__45__15__45__LIPOXYGENASE__45__RXN" name="Arachidonate 15-lipoxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Alox8 ) or ( Alox15 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 8-lipoxygenase ) or ( arachidonate 15-lipoxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.33</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z8Z11Z13E__45__15S__45__15__45__HYDROPEROXYICOS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOGENTISATE__45__12__45__DIOXYGENASE__45__RXN" name="Homogentisate 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homogentisate 1, 2-dioxygenase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.5</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp2c65 ) or ( Cyp2c37 ) or ( Cyp3a13 ) or ( Cyp2c40 ) or ( Cyp2a4 ) or ( Cyp2a5 ) or ( Cyp2b9 ) or ( Cyp2c44 ) or ( Cyp2s1 ) or ( Cyp2c39 ) or ( Cyp3a16 ) or ( Cyp3a11 ) or ( Cyp2d10 ) or ( Cyp1a1 ) or ( Cyp2b19 ) or ( Cyp2d11 ) or ( Cyp2c29 ) or ( Cyp2a12 ) or ( Cyp2e1 ) or ( Cyp2c70 ) or ( Cyp3a41a ) or ( Cyp2c38 ) or ( Cyp1b1 ) or ( Cyp2b10 ) or ( Cyp3a25 ) or ( Cyp1a2 ) or ( Cyp2d26 ) or ( Cyp2d9 ) or ( Cyp19a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 2, subfamily c, polypeptide 65 ) or ( cytochrome P450, family 2. subfamily c, polypeptide 37 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 13 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 40 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 4 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 5 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 9 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 44 ) or ( cytochrome P450, family 2, subfamily s, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 39 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 16 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 10 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 19 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 29 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 12 ) or ( cytochrome P450, family 2, subfamily e, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 70 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 41A ) or ( cytochrome P450, family 2, subfamily c, polypeptide 38 ) or ( cytochrome P450, family 1, subfamily b, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 10 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 25 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 2 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 26 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 9 ) or ( cytochrome P450, family 19, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLMALONYL__45__COA__45__EPIM__45__RXN" name="Methylmalonyl-CoA epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mcee )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonyl CoA epimerase )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: isoleucine degradation</html:p>
<html:p>SUBSYSTEM: 2-oxobutanoate degradation I</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLYLSULFKIN__45__RXN" name="Adenylylsulfate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Papss1 ) or ( Papss2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&apos;-phosphoadenosine 5&apos;-phosphosulfate synthase 1 ) or ( 3&apos;-phosphoadenosine 5&apos;-phosphosulfate synthase 2 )</html:p>
<html:p>SUBSYSTEM: sulfur metabolism</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.25</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_PROPIONYL__45__COA_COF_RXN" name="CO-A_TO_PROPIONYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__66__45__RXN" name="Inositol-3,4-bisphosphate 4-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Inpp4b ) or ( Inpp4a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate-4-phosphatase, type II ) or ( inositol polyphosphate-4-phosphatase, type I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.66</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__MYO__45__INOSITOL__45__34__45__BISPHOSP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIGLUCODIACETYL__45__DOCOSANOATE__45__LYSIS__45__RXN" name="acetic-ester acetylhydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Saac ) or ( Esa4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sialic acid O-acetylation ) or ( esterase A4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIGLUCODIACETYL__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="DIGLUCOACETYL__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Abat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__27__45__RXN" name="Sphingomyelin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sgms1 ) or ( Sgms2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingomyelin synthase 1 ) or ( sphingomyelin synthase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.27</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ceramides__124__" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Sphingomyelins__124__" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8631" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldoa ) or ( Aldoc ) or ( Aldob ) or ( Aldoart2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldolase 1, A isoform ) or ( aldolase 3, C isoform ) or ( aldolase 2, B isoform ) or ( aldolase 1, A isoform, retrogene 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="POLYNUCLEOTIDE__45__3__45__PHOSPHATASE__45__RXN" name="Polynucleotide 3&apos;-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnkp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polynucleotide kinase 3&apos;- phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.32</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="a__32__3__38__amp__59__apos__59____45__phosphopolynucleotide" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="a__32__polynucleotide" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GABATRANSAM__45__RXN" name="4-aminobutyrate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Abat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase )</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation I</html:p>
<html:p>SUBSYSTEM: glutamate degradation III (via 4-aminobutyrate)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLSULFAT__45__RXN" name="Arylsulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Arsj ) or ( Sulf1 ) or ( Sumf2 ) or ( Sulf2 ) or ( Arsk ) or ( Arsb ) or ( Arsi ) or ( Arsg ) or ( Sumf1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylsulfatase J ) or ( sulfatase 1 ) or ( sulfatase modifying factor 2 ) or ( sulfatase 2 ) or ( arylsulfatase K ) or ( arylsulfatase B ) or ( arylsulfatase i ) or ( arylsulfatase G ) or ( sulfatase modifying factor 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Sulfate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__83" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a7c ) or ( Ugt2b5 ) or ( Ugt1a1 ) or ( Ugt2b1 ) or ( Ugt1a6a ) or ( Ugt2b35 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glucuronosyltransferase 1 family, polypeptide A7C ) or ( UDP glucuronosyltransferase 2 family, polypeptide B5 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A1 ) or ( UDP glucuronosyltransferase 2 family, polypeptide B1 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A6A ) or ( UDP glucuronosyltransferase 2 family, polypeptide B35 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2744" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_SUC_COF_RXN" name="2-KETOGLUTARATE_TO_SUC_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__3__46__2__46__9__45__RXN" name="Microsomal epoxide hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ephx1 ) or ( Abhd6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( epoxide hydrolase 1, microsomal ) or ( abhydrolase domain containing 6 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8984" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8985" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__OXYGENASE__45__RXN" name="Myo-inositol oxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Miox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myo-inositol oxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.99.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIAMIN__45__TRIPHOSPHATASE__45__RXN" name="Thiamine-triphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Thtpa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamine triphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__611" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSHTRAN__45__RXN" name="Glutathione transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gstt1 ) or ( Gsta2 ) or ( Gstm6 ) or ( Mgst3 ) or ( Gsta3 ) or ( Gstm2 ) or ( Gstz1 ) or ( Gstt3 ) or ( Gstp1 ) or ( Gsto1 ) or ( Gsta ) or ( Gstm4 ) or ( Gsto2 ) or ( Gstt4 ) or ( Gstm7 ) or ( Gsta1 ) or ( Mgst1 ) or ( Gstm3 ) or ( Gstt2 ) or ( Gsta4 ) or ( Gstk1 ) or ( Gstm5 ) or ( Gstm1 ) or ( Gstp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione S-transferase, theta 1 ) or ( glutathione S-transferase, alpha 2 (Yc2) ) or ( glutathione S-transferase, mu 6 ) or ( microsomal glutathione S-transferase 3 ) or ( glutathione S-transferase, alpha 3 ) or ( glutathione S-transferase, mu 2 ) or ( glutathione transferase zeta 1 (maleylacetoacetate isomerase) ) or ( glutathione S-transferase, theta 3 ) or ( glutathione S-transferase, pi 1 ) or ( glutathione S-transferase omega 1 ) or ( glutathione S-transferase cluster ) or ( glutathione S-transferase, mu 4 ) or ( glutathione S-transferase omega 2 ) or ( glutathione S-transferase, theta 4 ) or ( glutathione S-transferase, mu 7 ) or ( glutathione S-transferase, alpha 1 (Ya) ) or ( microsomal glutathione S-transferase 1 ) or ( glutathione S-transferase, mu 3 ) or ( glutathione S-transferase, theta 2 ) or ( glutathione S-transferase, alpha 4 ) or ( glutathione S-transferase kappa 1 ) or ( glutathione S-transferase, mu 5 ) or ( glutathione S-transferase, mu 1 ) or ( glutathione S-transferase, pi 2 )</html:p>
<html:p>SUBSYSTEM: glutathione-mediated detoxification</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>SIDE: HX</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RX" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HX" stoichiometry="1"/>
      <speciesReference species="__124__S__45__Substituted__45__Glutathione__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__REDUCT__45__RXN" name="GMP reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gmpr ) or ( Gmpr2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanosine monophosphate reductase ) or ( guanosine monophosphate reductase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Rrm2 ) or ( Rrm2b ) or ( Rrm1 ) or ( Rrm1-rs13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleotide reductase M2 ) or ( ribonucleotide reductase M2 B (TP53 inducible) ) or ( ribonucleotide reductase M1 ) or ( ribonucleotide reductase M1, related sequence 13 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.4.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxy__45__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTARYL__45__COA__45__DEHYDROGENASE__45__RXN" name="Glutaryl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gcdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl-Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tyr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8851" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPOXYGENASE__45__RXN" name="Lipoxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Alox5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 5-lipoxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_13__45__HYDROPEROXYOCTADECA__45__911__45__DIENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMATE__45__FORMIMINOTRANSFERASE__45__RXN" name="Glutamate formiminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ftcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formiminotransferase cyclodeaminase )</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.5</html:p>
<html:p>SIDE: THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__FORMIMINO__45__L__45__GLUTAMATE" stoichiometry="1"/>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__671" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG1P__45__URIDYLTRANS__45__RXN" name="UDP-N-acetylglucosamine pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Uap1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine pyrophosphorylase 1 )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.23</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__ACYLGLYCEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="2-acylglycerol O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mogat2 ) or ( Mogat1 ) or ( Dgat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monoacylglycerol O-acyltransferase 2 ) or ( monoacylglycerol O-acyltransferase 1 ) or ( diacylglycerol O-acyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.22</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__409" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R147__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADDALT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Adad1 ) or ( Adarb1 ) or ( Ada ) or ( Adad2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine deaminase domain containing 1 (testis specific) ) or ( adenosine deaminase, RNA-specific, B1 ) or ( adenosine deaminase ) or ( adenosine deaminase domain containing 2 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYINOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__METHYLTHIOADENOSINE__45__PHOSPHORYLASE__45__RXN" name="5&apos;-methylthioadenosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mtap )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylthioadenosine phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp2c65 ) or ( Cyp2c37 ) or ( Cyp3a13 ) or ( Cyp2c40 ) or ( Cyp2a4 ) or ( Cyp2a5 ) or ( Cyp2b9 ) or ( Cyp2c44 ) or ( Cyp2s1 ) or ( Cyp2c39 ) or ( Cyp3a16 ) or ( Cyp3a11 ) or ( Cyp2d10 ) or ( Cyp1a1 ) or ( Cyp2b19 ) or ( Cyp2d11 ) or ( Cyp2c29 ) or ( Cyp2a12 ) or ( Cyp2e1 ) or ( Cyp2c70 ) or ( Cyp3a41a ) or ( Cyp2c38 ) or ( Cyp1b1 ) or ( Cyp2b10 ) or ( Cyp3a25 ) or ( Cyp1a2 ) or ( Cyp2d26 ) or ( Cyp2d9 ) or ( Cyp19a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 2, subfamily c, polypeptide 65 ) or ( cytochrome P450, family 2. subfamily c, polypeptide 37 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 13 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 40 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 4 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 5 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 9 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 44 ) or ( cytochrome P450, family 2, subfamily s, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 39 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 16 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 10 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 19 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 29 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 12 ) or ( cytochrome P450, family 2, subfamily e, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 70 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 41A ) or ( cytochrome P450, family 2, subfamily c, polypeptide 38 ) or ( cytochrome P450, family 1, subfamily b, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 10 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 25 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 2 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 26 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 9 ) or ( cytochrome P450, family 19, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2750" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__225__45__RXN" name="N-acetylglucosaminyl-proteoglycan 4-&amp;beta;-glucuronosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ext1 ) or ( Ext2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( exostoses (multiple) 1 ) or ( exostoses (multiple) 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.225</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__alpha__45__D__45__glucuronate" stoichiometry="1"/>
      <speciesReference species="N__45__acetyl__45__alpha__45__D__45__glucosaminyl__45____40__1__45____62__4__41____45__beta__45__D__45__glucuronosyl__45__proteoglycan" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="beta__45__D__45__glucuronosyl__45____40__1__45____62__4__41____45__N__45__acetyl__45__alpha__45__D__45__glucosaminyl__45____40__1__45____62__4__41____45__beta__45__D__45__glucuronosyl__45__proteoglycan" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__28__45__RXN" name="Phenylethanolamine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylethanolamine-N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.28</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLETHANOLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__METHYLPHENYLETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__162" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a7c ) or ( Ugt2b5 ) or ( Ugt1a1 ) or ( Ugt2b1 ) or ( Ugt1a6a ) or ( Ugt2b35 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glucuronosyltransferase 1 family, polypeptide A7C ) or ( UDP glucuronosyltransferase 2 family, polypeptide B5 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A1 ) or ( UDP glucuronosyltransferase 2 family, polypeptide B1 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A6A ) or ( UDP glucuronosyltransferase 2 family, polypeptide B35 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2750" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2752" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINE__45__KINASE__45__RXN" name="Ethanolamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Chka ) or ( Etnk2 ) or ( Chkb ) or ( Etnk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline kinase alpha ) or ( ethanolamine kinase 2 ) or ( choline kinase beta ) or ( ethanolamine kinase 1 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.82</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALA__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Treh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalase (brush-border membrane glycoprotein) )</html:p>
<html:p>SUBSYSTEM: trehalose degradation II (high osmolarity)</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.28</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp2c65 ) or ( Cyp2c37 ) or ( Cyp3a13 ) or ( Cyp2c40 ) or ( Cyp2a4 ) or ( Cyp2a5 ) or ( Cyp2b9 ) or ( Cyp2c44 ) or ( Cyp2s1 ) or ( Cyp2c39 ) or ( Cyp3a16 ) or ( Cyp3a11 ) or ( Cyp2d10 ) or ( Cyp1a1 ) or ( Cyp2b19 ) or ( Cyp2d11 ) or ( Cyp2c29 ) or ( Cyp2a12 ) or ( Cyp2e1 ) or ( Cyp2c70 ) or ( Cyp3a41a ) or ( Cyp2c38 ) or ( Cyp1b1 ) or ( Cyp2b10 ) or ( Cyp3a25 ) or ( Cyp1a2 ) or ( Cyp2d26 ) or ( Cyp2d9 ) or ( Cyp19a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 2, subfamily c, polypeptide 65 ) or ( cytochrome P450, family 2. subfamily c, polypeptide 37 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 13 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 40 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 4 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 5 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 9 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 44 ) or ( cytochrome P450, family 2, subfamily s, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 39 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 16 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 10 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 19 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 29 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 12 ) or ( cytochrome P450, family 2, subfamily e, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 70 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 41A ) or ( cytochrome P450, family 2, subfamily c, polypeptide 38 ) or ( cytochrome P450, family 1, subfamily b, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 10 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 25 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 2 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 26 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 9 ) or ( cytochrome P450, family 19, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2751" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PORPHOBILSYNTH__45__RXN" name="Porphobilinogen synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Alad )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminolevulinate, delta-, dehydratase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.24</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__6__45__RXN" name="N-acetyllactosaminide &amp;alpha;-2,3-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( St3gal3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ST3 beta-galactoside alpha-2,3-sialyltransferase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.6</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__14__45__N__45__ACETYL__45__ETCETERA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__23__45__BETA__45__ETCETER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__168" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a7c ) or ( Ugt2b5 ) or ( Ugt1a1 ) or ( Ugt2b1 ) or ( Ugt1a6a ) or ( Ugt2b35 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glucuronosyltransferase 1 family, polypeptide A7C ) or ( UDP glucuronosyltransferase 2 family, polypeptide B5 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A1 ) or ( UDP glucuronosyltransferase 2 family, polypeptide B1 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A6A ) or ( UDP glucuronosyltransferase 2 family, polypeptide B35 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2747" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__169" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp2c65 ) or ( Cyp2c37 ) or ( Cyp3a13 ) or ( Cyp2c40 ) or ( Cyp2a4 ) or ( Cyp2a5 ) or ( Cyp2b9 ) or ( Cyp2c44 ) or ( Cyp2s1 ) or ( Cyp2c39 ) or ( Cyp3a16 ) or ( Cyp3a11 ) or ( Cyp2d10 ) or ( Cyp1a1 ) or ( Cyp2b19 ) or ( Cyp2d11 ) or ( Cyp2c29 ) or ( Cyp2a12 ) or ( Cyp2e1 ) or ( Cyp2c70 ) or ( Cyp3a41a ) or ( Cyp2c38 ) or ( Cyp1b1 ) or ( Cyp2b10 ) or ( Cyp3a25 ) or ( Cyp1a2 ) or ( Cyp2d26 ) or ( Cyp2d9 ) or ( Cyp19a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 2, subfamily c, polypeptide 65 ) or ( cytochrome P450, family 2. subfamily c, polypeptide 37 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 13 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 40 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 4 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 5 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 9 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 44 ) or ( cytochrome P450, family 2, subfamily s, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 39 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 16 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 10 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 19 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 29 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 12 ) or ( cytochrome P450, family 2, subfamily e, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 70 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 41A ) or ( cytochrome P450, family 2, subfamily c, polypeptide 38 ) or ( cytochrome P450, family 1, subfamily b, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 10 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 25 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 2 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 26 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 9 ) or ( cytochrome P450, family 19, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3188" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R344__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mmab )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonic aciduria (cobalamin deficiency) type B homolog (human) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__694" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mgam )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maltase-glucoamylase )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__12__46__1__45__RXN" name="Dual-specificity kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tesk2 ) or ( Dyrk3 ) or ( Dyrk4 ) or ( Clk4 ) or ( Aurka ) or ( Tesk1 ) or ( Clk1 ) or ( Dyrk1a ) or ( Clk2 ) or ( Prkar1b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( testis-specific kinase 2 ) or ( dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 ) or ( dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 ) or ( CDC like kinase 4 ) or ( aurora kinase A ) or ( testis specific protein kinase 1 ) or ( CDC-like kinase 1 ) or ( dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a ) or ( CDC-like kinase 2 ) or ( protein kinase, cAMP dependent regulatory, type I beta )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.12.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PUTRESCINE__45__OXIDASE__45__RXN" name="Putrescine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Maob )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amine oxidase activity )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5181" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Amy1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amylase 1, salivary )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOHEXAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__62" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase 1 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__61" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp2c65 ) or ( Cyp2c37 ) or ( Cyp3a13 ) or ( Cyp2c40 ) or ( Cyp2a4 ) or ( Cyp2a5 ) or ( Cyp2b9 ) or ( Cyp2c44 ) or ( Cyp2s1 ) or ( Cyp2c39 ) or ( Cyp3a16 ) or ( Cyp3a11 ) or ( Cyp2d10 ) or ( Cyp1a1 ) or ( Cyp2b19 ) or ( Cyp2d11 ) or ( Cyp2c29 ) or ( Cyp2a12 ) or ( Cyp2e1 ) or ( Cyp2c70 ) or ( Cyp3a41a ) or ( Cyp2c38 ) or ( Cyp1b1 ) or ( Cyp2b10 ) or ( Cyp3a25 ) or ( Cyp1a2 ) or ( Cyp2d26 ) or ( Cyp2d9 ) or ( Cyp19a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 2, subfamily c, polypeptide 65 ) or ( cytochrome P450, family 2. subfamily c, polypeptide 37 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 13 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 40 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 4 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 5 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 9 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 44 ) or ( cytochrome P450, family 2, subfamily s, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 39 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 16 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 10 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 19 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 29 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 12 ) or ( cytochrome P450, family 2, subfamily e, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 70 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 41A ) or ( cytochrome P450, family 2, subfamily c, polypeptide 38 ) or ( cytochrome P450, family 1, subfamily b, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 10 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 25 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 2 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 26 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 9 ) or ( cytochrome P450, family 19, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBREDUCT__45__RXN" name="Pyrroline-5-carboxylate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pycrl ) or ( Pycr1 ) or ( Pycr2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrroline-5-carboxylate reductase-like ) or ( pyrroline-5-carboxylate reductase 1 ) or ( pyrroline-5-carboxylate reductase family, member 2 )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis V (from arginine)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPCARBTRANS__45__RXN" name="Aspartate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cad )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.2</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh5 ) or ( Aldh2 ) or ( Aldh7a1 ) or ( Aldh1b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 5, testis ) or ( aldehyde dehydrogenase 2, mitochondrial ) or ( aldehyde dehydrogenase family 7, member A1 ) or ( aldehyde dehydrogenase 1 family, member B1 )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLYSINE__45__DEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aasdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-aminoadipate-semialdehyde dehydrogenase activity )</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.31</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catalase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__24__45__RXN" name="Mitogen-activated protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mapk1 ) or ( Mapk14 ) or ( Mapk7 ) or ( Mapk1ip1l ) or ( Mapk11 ) or ( Mapkbp1 ) or ( Mapk6 ) or ( Mapk8ip1 ) or ( Mapk15 ) or ( Aurka ) or ( Mapk8 ) or ( Mapk3-rs1 ) or ( Mapk3 ) or ( Mapk13 ) or ( Mapk8ip2 ) or ( Mapk9 ) or ( Mapk8ip3 ) or ( Mapk10 ) or ( Mapk1ip1 ) or ( Mapk4 ) or ( Nlk ) or ( Mapk12 ) or ( Dusp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mitogen-activated protein kinase 1 ) or ( mitogen-activated protein kinase 14 ) or ( mitogen-activated protein kinase 7 ) or ( mitogen-activated protein kinase 1 interacting protein 1-like ) or ( mitogen-activated protein kinase 11 ) or ( mitogen-activated protein kinase binding protein 1 ) or ( mitogen-activated protein kinase 6 ) or ( mitogen-activated protein kinase 8 interacting protein 1 ) or ( mitogen-activated protein kinase 15 ) or ( aurora kinase A ) or ( mitogen-activated protein kinase 8 ) or ( mitogen-activated protein kinase 3, related sequence 1 ) or ( mitogen-activated protein kinase 3 ) or ( mitogen-activated protein kinase 13 ) or ( mitogen-activated protein kinase 8 interacting protein 2 ) or ( mitogen-activated protein kinase 9 ) or ( mitogen-activated protein kinase 8 interacting protein 3 ) or ( mitogen-activated protein kinase 10 ) or ( mitogen-activated protein kinase 1 interacting protein 1 ) or ( mitogen-activated protein kinase 4 ) or ( nemo like kinase ) or ( mitogen-activated protein kinase 12 ) or ( dual specificity phosphatase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8442" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="D__45__RIBULOSE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8259" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRCARBOXY__45__RXN" name="Phosphoribosylaminoimidazole carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Paics )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLATE__45____45__COA__45__LIGASE__45__RXN" name="Cholate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Slc27a5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( solute carrier family 27 (fatty acid transporter), member 5 )</html:p>
<html:p>SUBSYSTEM: cholate degradation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.7</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIENOYLCOAREDUCT__45__RXN" name="2,4-dienoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Decr1 ) or ( Decr2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dienoyl CoA reductase 1, mitochondrial ) or ( 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="T2__45__DECENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="T2__45__C4__45__DECADIENYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="POLYAMINE__45__OXIDASE__45__RXN" name="Polyamine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Paox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyamine oxidase (exo-N4-amino) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N1__45__ACETYLSPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__AMINO__45__PROPANAL" stoichiometry="1"/>
      <speciesReference species="CPD__45__568" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="myo-inositol-1-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Isyna1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myo-inositol 1-phosphate synthase A1 )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINO__45__CARBOXYMUCONATE__45__SEMIALDEHYDE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acmsd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amino carboxymuconate semialdehyde decarboxylase )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.45</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4401" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Enpp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleotide pyrophosphatase/phosphodiesterase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="NMNH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXII__45__RXN" name="Hydroxyacylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hagh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacyl glutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLCHOLINESTERASE__45__RXN" name="Acetylcholinesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ache )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylcholinesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDYLINOSITOL__45__BISPHOSPHATASE__45__RXN" name="Phosphatidylinositol-bisphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ocrl ) or ( Synj1 ) or ( Inpp5e )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oculocerebrorenal syndrome of Lowe ) or ( synaptojanin 1 ) or ( inositol polyphosphate-5-phosphatase E )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.36</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYLINOSITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__79__45__RXN" name="galactosylgalactosylglucosylceramide &amp;beta;-D-acetyl- galactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B3galnt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.79</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTOSYL__45__14__45__D__45__GALACTOSYL__45__14__45__D__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINYL__45__13__45__D__45__GALACT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp2c65 ) or ( Cyp2c37 ) or ( Cyp3a13 ) or ( Cyp2c40 ) or ( Cyp2a4 ) or ( Cyp2a5 ) or ( Cyp2b9 ) or ( Cyp2c44 ) or ( Cyp2s1 ) or ( Cyp2c39 ) or ( Cyp3a16 ) or ( Cyp3a11 ) or ( Cyp2d10 ) or ( Cyp1a1 ) or ( Cyp2b19 ) or ( Cyp2d11 ) or ( Cyp2c29 ) or ( Cyp2a12 ) or ( Cyp2e1 ) or ( Cyp2c70 ) or ( Cyp3a41a ) or ( Cyp2c38 ) or ( Cyp1b1 ) or ( Cyp2b10 ) or ( Cyp3a25 ) or ( Cyp1a2 ) or ( Cyp2d26 ) or ( Cyp2d9 ) or ( Cyp19a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 2, subfamily c, polypeptide 65 ) or ( cytochrome P450, family 2. subfamily c, polypeptide 37 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 13 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 40 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 4 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 5 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 9 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 44 ) or ( cytochrome P450, family 2, subfamily s, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 39 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 16 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 10 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 19 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 29 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 12 ) or ( cytochrome P450, family 2, subfamily e, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 70 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 41A ) or ( cytochrome P450, family 2, subfamily c, polypeptide 38 ) or ( cytochrome P450, family 1, subfamily b, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 10 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 25 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 2 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 26 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 9 ) or ( cytochrome P450, family 19, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: bupropion degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3481" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3483" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THROMBOXANE__45__A__45__SYNTHASE__45__RXN" name="thromboxane-A synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tbxas1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thromboxane A synthase 1, platelet )</html:p>
<html:p>SUBSYSTEM: biosynthesis of prostaglandins</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROSTAGLANDIN__45__H2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA11__45__ALPHA__45__EPOXY__45__15__45__HYDROXYTHROMBA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__2__46__12__45__RXN" name="Nicotinamide phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nampt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinamide phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.12</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__LACTATE__45__DEHYDROGENASE__45__CYTOCHROME__45__RXN" name="D-lactate dehydrogenase (cytochrome)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ldhd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-lactate dehydrogenase (cytochrome) activity )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2361" stoichiometry="2"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__2363" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEYLACETOACETATE__45__ISOMERASE__45__RXN" name="Maleylacetoacetate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gstz1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione transferase zeta 1 (maleylacetoacetate isomerase) )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__17__46__99__46__3__45__RXN" name="3-&amp;alpha;,7-&amp;alpha;,12-&amp;alpha;-trihydroxy-5-&amp;beta;-cholestanoyl-CoA 24 hydroxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Acox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-Coenzyme A oxidase 2, branched chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__71" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7243" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adh1 ) or ( Adh4 ) or ( D3Nds9 ) or ( Adh7 ) or ( Adh6b ) or ( Adh5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase 1 (class I) ) or ( alcohol dehydrogenase 4 (class II), pi polypeptide ) or ( DNA segment, Chr 3, Nuffield Department of Surgery 9 ) or ( alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ) or ( alcohol dehydrogenase 6B (class V) ) or ( alcohol dehydrogenase 5 (class III), chi polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDASE__45__RXN" name="Ceramidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Asah1 ) or ( Asah3 ) or ( Asah2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acylsphingosine amidohydrolase 1 ) or ( N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 ) or ( N-acylsphingosine amidohydrolase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.23</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="SPHINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Amine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Inmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indolethylamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.49</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AN__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__45__METHYLATED__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPCOASYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acadm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-Coenzyme A dehydrogenase, medium chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5199" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnp1 ) or ( Pnp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase 1 ) or ( purine-nucleoside phosphorylase 2 )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA__45__DECARBOXYLASE__45__RXN" name="Malonyl-CoA decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mlycd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malonyl-CoA decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP cyclohydrolase I" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gch1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP cyclohydrolase 1 )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.16</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__170" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp2c65 ) or ( Cyp2c37 ) or ( Cyp3a13 ) or ( Cyp2c40 ) or ( Cyp2a4 ) or ( Cyp2a5 ) or ( Cyp2b9 ) or ( Cyp2c44 ) or ( Cyp2s1 ) or ( Cyp2c39 ) or ( Cyp3a16 ) or ( Cyp3a11 ) or ( Cyp2d10 ) or ( Cyp1a1 ) or ( Cyp2b19 ) or ( Cyp2d11 ) or ( Cyp2c29 ) or ( Cyp2a12 ) or ( Cyp2e1 ) or ( Cyp2c70 ) or ( Cyp3a41a ) or ( Cyp2c38 ) or ( Cyp1b1 ) or ( Cyp2b10 ) or ( Cyp3a25 ) or ( Cyp1a2 ) or ( Cyp2d26 ) or ( Cyp2d9 ) or ( Cyp19a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 2, subfamily c, polypeptide 65 ) or ( cytochrome P450, family 2. subfamily c, polypeptide 37 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 13 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 40 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 4 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 5 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 9 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 44 ) or ( cytochrome P450, family 2, subfamily s, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 39 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 16 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 10 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 19 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 11 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 29 ) or ( cytochrome P450, family 2, subfamily a, polypeptide 12 ) or ( cytochrome P450, family 2, subfamily e, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily c, polypeptide 70 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 41A ) or ( cytochrome P450, family 2, subfamily c, polypeptide 38 ) or ( cytochrome P450, family 1, subfamily b, polypeptide 1 ) or ( cytochrome P450, family 2, subfamily b, polypeptide 10 ) or ( cytochrome P450, family 3, subfamily a, polypeptide 25 ) or ( cytochrome P450, family 1, subfamily a, polypeptide 2 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 26 ) or ( cytochrome P450, family 2, subfamily d, polypeptide 9 ) or ( cytochrome P450, family 19, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3188" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2749" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__SYNTHASE__45__RXN" name="Hydroxymethylglutaryl-CoA synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hmgcs1 ) or ( Hmgcs2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 ) or ( 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.5</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHA__45__AMYL__45__RXN" name="&amp;alpha;-amylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Amy1 ) or ( Gbe1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amylase 1, salivary ) or ( glucan (1,4-alpha-), branching enzyme 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINEPNACETYLTRANS__45__RXN" name="Glucosamine-phosphate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gnpnat1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine-phosphate N-acetyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.4</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOASYN__45__RXN" name="long-chain-fatty-acid--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acsl4 ) or ( Slc27a5 ) or ( Acsbg1 ) or ( Acsl5 ) or ( Acsl3 ) or ( Acsm1 ) or ( Acsl6 ) or ( Slc27a6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA synthetase long-chain family member 4 ) or ( solute carrier family 27 (fatty acid transporter), member 5 ) or ( acyl-CoA synthetase bubblegum family member 1 ) or ( acyl-CoA synthetase long-chain family member 5 ) or ( acyl-CoA synthetase long-chain family member 3 ) or ( acyl-CoA synthetase medium-chain family member 1 ) or ( acyl-CoA synthetase long-chain family member 6 ) or ( solute carrier family 27 (fatty acid transporter), member 6 )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUTP__45__PYROP__45__RXN" name="dUTP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Itpa ) or ( Dut )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine triphosphatase (nucleoside triphosphate pyrophosphatase) ) or ( deoxyuridine triphosphatase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__ARGININE__45__DEIMINASE__45__RXN" name="Protein-arginine deiminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Padi4 ) or ( Padi3 ) or ( Padi1 ) or ( Padi2 ) or ( Padi6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptidyl arginine deiminase, type IV ) or ( peptidyl arginine deiminase, type III ) or ( peptidyl arginine deiminase, type I ) or ( peptidyl arginine deiminase, type II ) or ( peptidyl arginine deiminase, type VI )</html:p>
<html:p>SUBSYSTEM: protein citrullination</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.15</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PEPTIDYL__45__L__45__ARGININE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMARYLACETOACETASE__45__RXN" name="Fumarylacetoacetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fah ) or ( Fahd1 ) or ( Fahd2a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarylacetoacetate hydrolase ) or ( fumarylacetoacetate hydrolase domain containing 1 ) or ( fumarylacetoacetate hydrolase domain containing 2A )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINASE__45__RXN" name="Adenosylhomocysteinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ahcyl1 ) or ( Ahcy ) or ( Ahcyl2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylhomocysteine hydrolase-like 1 ) or ( S-adenosylhomocysteine hydrolase ) or ( S-adenosylhomocysteine hydrolase-like 2 )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>PROTEIN_CLASS: 3.3.1.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__99__46__38__45__RXN" name="Cholesterol 25-hydroxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ch25h )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cholesterol 25-hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.38</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7241" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNB__45__RXN" name="asparagine synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Asnsd1 ) or ( Asns )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine synthetase domain containing 1 ) or ( asparagine synthetase )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.4</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__8__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpd1l ) or ( Gpd1 ) or ( D15Nds4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase 1-like ) or ( glycerol-3-phosphate dehydrogenase 1 (soluble) ) or ( DNA segment, Chr 15, Nuffield Department of Surgery 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPSUGARHYDRO__45__RXN" name="UDP-sugar diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nudt14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nudix (nucleoside diphosphate linked moiety X)-type motif 14 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.45</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__UDP__45__sugar__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="__124__Sugar__45__1__45__Phosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLSEROTONIN__45__O__45__METHYLTRANSFERASE__45__RXN" name="Acetylserotonin O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Asmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylserotonin O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: biosynthesis of serotonin and melatonin</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.4</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__SEROTONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__5__45__METHOXY__45__TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEXOKINASE__45__RXN" name="Hexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hk3 ) or ( Hkdc1 ) or ( Hk1 ) or ( Hk2 ) or ( Ltk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase 3 ) or ( hexokinase domain containing 1 ) or ( hexokinase 1 ) or ( hexokinase 2 ) or ( leukocyte tyrosine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__HEXOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__HEXOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__821" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Prodh2 ) or ( Prodh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline dehydrogenase (oxidase) 2 ) or ( proline dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__62__45__RXN" name="Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Minpp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multiple inositol polyphosphate histidine phosphatase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.62</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__174__45__RXN" name="Glucuronylgalactosylproteoglycan &amp;beta;-1,4-N- acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Csgalnact1 ) or ( Csgalnact2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chondroitin sulfate N-acetylgalactosaminyltransferase 1 ) or ( chondroitin sulfate N-acetylgalactosaminyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.174</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCURONYL__45__ETCETERA__45__GALACTOSYLPROTEOGLYC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__ETCETERA__45__GALACTOSYLPROTEOGLYCAN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA_TO_CO__45__A_COF_RXN" name="ACETYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mthfd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SELENOCYSTEINE__45__LYASE__45__RXN" name="Selenocysteine lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Scly )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( selenocysteine lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__SELENOCYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__678" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLESTEROL__45__7__45__ALPHA__45__MONOOXYGENASE__45__RXN" name="Cholesterol 7-&amp;alpha;-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp7a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 7, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.17</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__266" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mthfd2 ) or ( Mthfd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase ) or ( methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5727" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTDECARBOX__45__RXN" name="Glutamate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gad1 ) or ( Gad2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamic acid decarboxylase 1 ) or ( glutamic acid decarboxylase 2 )</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>SUBSYSTEM: glutamate degradation IX (via 4-aminobutyrate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation III (via 4-aminobutyrate)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.15</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOKIN__45__RXN" name="Glucokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gck )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucokinase )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: trehalose degradation II (high osmolarity)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="ribose-phosphate diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AU021838 ) or ( Prps1l1 ) or ( Mipol1 ) or ( Prps2 ) or ( Prps1 ) or ( Prpsap2 ) or ( Prpsap1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( magnesium ion binding ) or ( phosphoribosyl pyrophosphate synthetase 1-like 1 ) or ( mirror-image polydactyly gene 1 homolog (human) ) or ( phosphoribosyl pyrophosphate synthetase 2 ) or ( phosphoribosyl pyrophosphate synthetase 1 ) or ( phosphoribosyl pyrophosphate synthetase-associated protein 2 ) or ( phosphoribosyl pyrophosphate synthetase-associated protein 1 )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHA__45__L__45__FUCOSIDASE__45__RXN" name="&amp;alpha;-L-fucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fuca1 ) or ( Fuca2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fucosidase, alpha-L- 1, tissue ) or ( fucosidase, alpha-L- 2, plasma )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.51</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AN__45__ALPHA__45__L__45__FUCOSIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MEPROPCOA__45__FAD__45__RXN" name="2-methylacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acad8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-Coenzyme A dehydrogenase family, member 8 )</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.12</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__10__45__RXN" name="Neolactotetraosylceramide &amp;alpha;-2,3-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( St3gal1 ) or ( St6galnac2 ) or ( St3gal6 ) or ( St6galnac1 ) or ( St3gal4 ) or ( St8sia1 ) or ( St6galnac3 ) or ( St6galnac5 ) or ( St3gal2 ) or ( St6galnac6 ) or ( St8sia5 ) or ( St8sia3 ) or ( St8sia2 ) or ( St8sia4 ) or ( St3gal3 ) or ( St8sia6 ) or ( St3gal5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ST3 beta-galactoside alpha-2,3-sialyltransferase 1 ) or ( ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 ) or ( ST3 beta-galactoside alpha-2,3-sialyltransferase 6 ) or ( ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 ) or ( ST3 beta-galactoside alpha-2,3-sialyltransferase 4 ) or ( ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 ) or ( ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 ) or ( ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ) or ( ST3 beta-galactoside alpha-2,3-sialyltransferase 2 ) or ( ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 ) or ( ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 ) or ( ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 ) or ( ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 ) or ( ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 ) or ( ST3 beta-galactoside alpha-2,3-sialyltransferase 3 ) or ( ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 ) or ( ST3 beta-galactoside alpha-2,3-sialyltransferase 5 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.10</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSYLCERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLNEURAMINYL__45__23__45__BETA__45__D__45__GALACTOSYL__45__ET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__15" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8610" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8611" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__16" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8611" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8612" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__17" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8612" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__19" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxysteroid (17-beta) dehydrogenase 7 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8614" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4184" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__45__45__RXN" name="CMP-N-acetylneuraminate monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cmah )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine monophospho-N-acetylneuraminic acid hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP__45__N__45__ACETYL__45__NEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__262" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLESTERASE__45__RXN" name="Arylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pon3 ) or ( Pon2 ) or ( Es16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( paraoxonase 3 ) or ( paraoxonase 2 ) or ( esterase 16 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phenyl__45__Acetates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4612" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETAGALACTOSID__45__RXN" name="&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gm1110 ) or ( Glb1l2 ) or ( Glb1 ) or ( Bgb ) or ( Glb1l3 ) or ( Lct )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gene model 1110, (NCBI) ) or ( galactosidase, beta 1-like 2 ) or ( galactosidase, beta 1 ) or ( beta-D-galactosidase in brain ) or ( galactosidase, beta 1 like 3 ) or ( lactase )</html:p>
<html:p>SUBSYSTEM: lactose degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__4__46__10__45__RXN" name="Nucleoside-triphosphate--adenylate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ak3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylate kinase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.10</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAMKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pdxk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal (pyridoxine, vitamin B6) kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__170__45__RXN" name="3-&amp;beta;-hydroxy-4-&amp;alpha;-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nsdhl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P) dependent steroid dehydrogenase-like )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__HYDROXY__45__4BETA__45__METHYL__45__5ALPHA__45__CHOLEST" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__ALPHA__45__METHYL__45__5__45__ALPHA__45__CHOLEST__45__7__45__EN__45__3__45__ON" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphogluconate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4729" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4604" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4607" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4728" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4209" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4603" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4727" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4209" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LEUKOTRIENE__45__A4__45__HYDROLASE__45__RXN" name="Leukotriene-A4 hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lta4h )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( leukotriene A4 hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEUKOTRIENE__45__A4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6Z8E10E14Z__45__5S12R__45__512__45__DIHYDROXYI" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4726" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__332" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4617" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4725" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__332" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4616" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh1a3 ) or ( Aldh3b1 ) or ( Aldh3a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family 1, subfamily A3 ) or ( aldehyde dehydrogenase 3 family, member B1 ) or ( aldehyde dehydrogenase family 3, subfamily A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5682" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4724" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__332" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4615" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4723" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.203</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4614" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4722" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__20" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4184" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8617" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__OXIDASE__45__RXN" name="Aldehyde oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aox1 ) or ( Aox4 ) or ( Aox3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase 1 ) or ( aldehyde oxidase 4 ) or ( aldehyde oxidase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOKIN__45__RXN" name="Ribokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Rbks )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribokinase )</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.15</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__24" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxysteroid (17-beta) dehydrogenase 7 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8620" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8621" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__21" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8617" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8618" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8619" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ESTRADIOL__45__17__45__BETA__45__DEHYDROGENASE__45__RXN" name="Estradiol 17 &amp;beta;-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b2 ) or ( Hsd17b7 ) or ( Hsd17b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxysteroid (17-beta) dehydrogenase 2 ) or ( hydroxysteroid (17-beta) dehydrogenase 7 ) or ( hydroxysteroid (17-beta) dehydrogenase 1 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of estrogens</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.62</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__352" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ESTRONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__27" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhcr7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DESMOSTEROL__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__68__45__RXN" name="1-phosphatidylinositol-4-phosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pip5k1a ) or ( Pip5k3 ) or ( Pip5k1b ) or ( Pip5k1c ) or ( Pip5kl1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha ) or ( phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III ) or ( phosphatidylinositol-4-phosphate 5-kinase, type 1 beta ) or ( phosphatidylinositol-4-phosphate 5-kinase, type 1 gamma ) or ( phosphatidylinositol-4-phosphate 5-kinase-like 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.68</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__25" name="Cholestenol &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ebp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylalkylamine Ca2+ antagonist (emopamil) binding protein )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8621" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__92__45__RXN" name="(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B4galnt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-1,4-N-acetyl-galactosaminyl transferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.92</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYLNEURAMINYL__45__ETCETERA__45__GLUCOSYLCERAMI" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1100" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__26" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc5d )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.6</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8646" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KERATAN__45__SULFOTRANSFERASE__45__RXN" name="Keratan sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Chst1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.21</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="KERATAN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KERATAN__45__6__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROSTAGLANDIN__45__E__45__SYNTHASE__45__RXN" name="Prostaglandin-E synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ptges2 ) or ( Ptges3 ) or ( Ptges )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostaglandin E synthase 2 ) or ( prostaglandin E synthase 3 (cytosolic) ) or ( prostaglandin E synthase )</html:p>
<html:p>SUBSYSTEM: biosynthesis of prostaglandins</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROSTAGLANDIN__45__H2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__15S__45__11__45__ALPHA15__45__DIHYDROXY__45__9__45__O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__7__45__RXN" name="Kynurenine--oxoglutarate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ccbl1 ) or ( Ccbl2 ) or ( Aadat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine conjugate-beta lyase 1 ) or ( cysteine conjugate-beta lyase 2 ) or ( aminoadipate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.7</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__476" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Bckdhb ) or ( Tktl2 ) or ( Tktl1 ) or ( Tkt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched chain ketoacid dehydrogenase E1, beta polypeptide ) or ( transketolase-like 2 ) or ( transketolase-like 1 ) or ( transketolase )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: non-oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__KIN__45__RXN" name="NAD(+) kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nadk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD kinase )</html:p>
<html:p>SUBSYSTEM: NAD phosphorylation and dephosphorylation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.23</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__IDITOL__45__2__45__DEHYDROGENASE__45__RXN" name="L-iditol 2-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sord )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__369" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Quinones__124___TO___124__Reduced__45__Quinones__124___COF_RXN" name="|Quinones|_TO_|Reduced-Quinones|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Reduced__45__Quinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATE__45__1__45__EPIMERASE__45__RXN" name="Glucose-6 phosphate 1-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__67__45__RXN" name="1-alkylglycerophosphocholine O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lpcat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysophosphatidylcholine acyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.67</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__Alkyl__45__sn__45__glycero__45__3__45__phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alkyl__45__acetyl__45__glycero__45__phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__155__45__RXN" name="&amp;alpha;-1,3(6)-mannosylglycoprotein &amp;beta;-1,6-N-acetyl- glucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mgat5 ) or ( Mgat5b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannoside acetylglucosaminyltransferase 5 ) or ( mannoside acetylglucosaminyltransferase 5, isoenzyme B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.155</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__2__45__N__45__ACETYL__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__26__45__BISN__45__ACETYL__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINESYN__45__RXN" name="Spermidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Srm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine synthase )</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__OCTAPRENYLTRANSTRANSFERASE__45__RXN" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pdss2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenyl (solanesyl) diphosphate synthase, subunit 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SOLANESYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMAMIDASE__45__RXN" name="Formamidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( For5 ) or ( For4 ) or ( For3 ) or ( For1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formamidase 5 ) or ( formamidase 4 ) or ( formamidase 3 ) or ( formamidase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.49</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__77__45__RXN" name="Acireductone synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Enoph1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enolase-phosphatase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.77</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8999" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6981" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gsto1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione S-transferase omega 1 )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
      <speciesReference species="DIMETHYLARSINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYLARSINOUS__45__ACID" stoichiometry="1"/>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IODIDE__45__PEROXIDASE__45__RXN" name="Iodide peroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Iyd ) or ( Tpo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( iodotyrosine deiodinase ) or ( thyroid peroxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__387" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IODINE__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__3__45__RXN" name="&amp;alpha;-N-acetylgalactosaminide &amp;alpha;-2,6-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( St6galnac6 ) or ( St6galnac1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 ) or ( ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.3</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCANO__45__13__45__ETCETERA__45__GLYCOPROTEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCANO__45__26__45__ETCETERA__45__GLYCOPROTEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6271" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5847" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5845" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLULOSE__45__REDUCTASE__45__RXN" name="D-xylulose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sord )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLOSE__45__1__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="D-xylose 1-dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrodiol dehydrogenase (dimeric) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.179</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__360" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__44__45__RXN" name="Glycerophosphoinositol glycerophosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gde1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerophosphodiester phosphodiesterase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.44</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__541" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__AMIDINOTRANSFERASE__45__RXN" name="Glycine amidinotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gatm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine amidinotransferase (L-arginine:glycine amidinotransferase) )</html:p>
<html:p>SUBSYSTEM: creatine biosynthesis</html:p>
<html:p>SUBSYSTEM: glycine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.4.1</html:p>
<html:p>SIDE: L__45__ORNITHINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="GUANIDOACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__20__45__RXN" name="Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrodiol dehydrogenase (dimeric) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.20</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__289" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__43__45__RXN" name="Phosphatidylcholine--sterol O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lcat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lecithin cholesterol acyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.43</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sterols__124__" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Steryl__45__Esters__124__" stoichiometry="1"/>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINAMIDE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Nicotinamide N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nnmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinamide N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.1</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__396" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOLICHYLDIPHOSPHATASE__45__RXN" name="Dolichyldiphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dolpp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dolichyl pyrophosphate phosphatase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.43</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__224" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICONUCADENYLYLTRAN__45__RXN" name="Nicotinate-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nmnat1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinamide nucleotide adenylyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4941" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ihpk3 ) or ( Ihpk1 ) or ( Ihpk2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol hexaphosphate kinase 3 ) or ( inositol hexaphosphate kinase 1 ) or ( inositol hexaphosphate kinase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIPHOSPHO__45__1D__45__MYO__45__INOSITOL__45__TETRAKISPHOSPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYRIBONUCSYN__45__RXN" name="Phosphoribosylamine--glycine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ifnar1 ) or ( Gart )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( interferon (alpha and beta) receptor 1 ) or ( phosphoribosylglycinamide formyltransferase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFATE__45__ADENYLYLTRANS__45__RXN" name="Sulfate adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Papss1 ) or ( Papss2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&apos;-phosphoadenosine 5&apos;-phosphosulfate synthase 1 ) or ( 3&apos;-phosphoadenosine 5&apos;-phosphosulfate synthase 2 )</html:p>
<html:p>SUBSYSTEM: sulfur metabolism</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.4</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6269" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5845" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5846" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYROXINE__45__DEIODINASE__45__RXN" name="Thyroxine deiodinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dio1 ) or ( Dio2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deiodinase, iodothyronine, type I ) or ( deiodinase, iodothyronine, type II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__THYROXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIOTHYRONINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__387" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHONDROITIN__45__4__45__SULFOTRANSFERASE__45__RXN" name="Chondroitin 4-sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Chst12 ) or ( Chst11 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbohydrate sulfotransferase 12 ) or ( carbohydrate sulfotransferase 11 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.5</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHONDROITIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHONDROITIN__45__4__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLCNACEPIM__45__RXN" name="UDP-N-acetylglucosamine 2-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gne )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__13__46__11__46__6__45__RXN" name="3-hydroxyanthranilate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Haao )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyanthranilate 3,4-dioxygenase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.6</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__20__46__4__46__2__45__RXN" name="Methylarsonate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gsto1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione S-transferase omega 1 )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: 1.20.4.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLARSONATE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLARSONITE" stoichiometry="1"/>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgs1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylglycerophosphate synthase 1 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.5</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FATTY__45__ACID__45__SYNTHASE__45__RXN" name="Fatty-acid synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fasn )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acid synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.85</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__40__N__43__1__41____32__COA" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA_TO_CO__45__A_COF_RXN" name="ACYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__AMINOTRANSFERASE__45__RXN" name="Tyrosine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine aminotransferase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.5</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__23__45__RXN" name="1-acylglycerophosphocholine O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lpcat1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysophosphatidylcholine acyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.23</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__163" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__14__45__RXN" name="Ethanolamine-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pcyt2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphate cytidylyltransferase 2, ethanolamine )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.14</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KYNURENINASE__45__RXN" name="Kynureninase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Kynu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynureninase (L-kynurenine hydrolase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SQUALENE__45__MONOOXYGENASE__45__RXN" name="Squalene monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sqle )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene epoxidase )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLGLUTACONYL__45__COA__45__HYDRATASE__45__RXN" name="Methylglutaconyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Auh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AU RNA binding protein/enoyl-coenzyme A hydratase )</html:p>
<html:p>SUBSYSTEM: leucine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.18</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__17__45__RXN" name="Phosphatidylethanolamine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pemt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylethanolamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.17</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__405" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1024" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1a4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1, member A4 (aldehyde reductase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Primary__45__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONOSYLTRANSFERASE__45__RXN" name="UDP-glucuronosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a7c ) or ( Ugt2a1 ) or ( Ugt2a3 ) or ( Ugt1a1 ) or ( Ugt2b34 ) or ( Ugt1a8 ) or ( Ugt1a9 ) or ( Ugt1a2 ) or ( Ugt2b35 ) or ( Ugt1a5 ) or ( Ugt2b36 ) or ( Ugt2b5 ) or ( Ugt2b38 ) or ( Ugt2b37 ) or ( Ugt1a6b ) or ( Ugt2b1 ) or ( Ugt1a6a ) or ( Ugt2a2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glucuronosyltransferase 1 family, polypeptide A7C ) or ( UDP glucuronosyltransferase 2 family, polypeptide A1 ) or ( UDP glucuronosyltransferase 2 family, polypeptide A3 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A1 ) or ( UDP glucuronosyltransferase 2 family, polypeptide B34 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A8 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A9 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A2 ) or ( UDP glucuronosyltransferase 2 family, polypeptide B35 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A5 ) or ( UDP glucuronosyltransferase 2 family, polypeptide B36 ) or ( UDP glucuronosyltransferase 2 family, polypeptide B5 ) or ( UDP glucuronosyltransferase 2 family, polypeptide B38 ) or ( UDP glucuronosyltransferase 2 family, polypeptide B37 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A6B ) or ( UDP glucuronosyltransferase 2 family, polypeptide B1 ) or ( UDP glucuronosyltransferase 1 family, polypeptide A6A ) or ( UDP glucuronosyltransferase 2 family, polypeptide A2 )</html:p>
<html:p>SUBSYSTEM: Vitamin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Non__45__Glucur__45__Glucuronoside__45__Acceptors__124__</html:p>
<html:p>SIDE: __124__Glucuronosylated__45__Glucuronoside__45__Acceptors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
      <speciesReference species="__124__Non__45__Glucur__45__Glucuronoside__45__Acceptors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Beta__45__D__45__Glucuronides__124__" stoichiometry="1"/>
      <speciesReference species="__124__Glucuronosylated__45__Glucuronoside__45__Acceptors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adh5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase 5 (class III), chi polypeptide )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.284</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCURONATE__45__REDUCTASE__45__RXN" name="Glucuronate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1a4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1, member A4 (aldehyde reductase) )</html:p>
<html:p>SUBSYSTEM: glucuronate degradation</html:p>
<html:p>SUBSYSTEM: Vitamin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.19</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GULONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GART__45__RXN" name="Phosphoribosylglycinamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gart )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.2</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYOSIN__45__LIGHT__45__CHAIN__45__PHOSPHATASE__45__RXN" name="[Myosin light-chain]-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mprip ) or ( Ppp2cb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myosin phosphatase Rho interacting protein ) or ( protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.53</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__MYOSIN__32__LIGHT__45__CHAIN__93____32__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__MYOSIN__32__LIGHT__45__CHAIN__93__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXY__45__KYNURENINASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Kynu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynureninase (L-kynurenine hydrolase) )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STERYL__45__SULFATASE__45__RXN" name="Steryl-sulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sts )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid sulfatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__HYDROXYANDROST__45__5__45__EN__45__17__45__ONE__45__3__45__SULFAT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
      <speciesReference species="_3__45__BETA__45__HYDROXYANDROST__45__5__45__EN__45__17__45__ONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__8__45__RXN" name="Dimethylaniline monooxygenase (N-oxide forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fmo4 ) or ( Fmo3 ) or ( Fmo5 ) or ( Fmo6 ) or ( Fmo1 ) or ( Fmo2 ) or ( Fmo9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavin containing monooxygenase 4 ) or ( flavin containing monooxygenase 3 ) or ( flavin containing monooxygenase 5 ) or ( flavin containing monooxygenase 6 ) or ( flavin containing monooxygenase 1 ) or ( flavin containing monooxygenase 2 ) or ( flavin containing monooxygenase 9 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NN__45__DIMETHYLANILINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NN__45__DIMETHYLANILINE__45__N__45__OXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAPOXNPHOSPHN__45__RXN" name="Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gapdh ) or ( Gapdhs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyceraldehyde-3-phosphate dehydrogenase ) or ( glyceraldehyde-3-phosphate dehydrogenase, spermatogenic )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD_TO_FADH2_COF_RXN" name="FAD_TO_FADH2_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FADH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_35__45__CYCLIC__45__GMP__45__PHOSPHODIESTERASE__45__RXN" name="3&apos;,5&apos;-cyclic-GMP phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pde6c ) or ( Pde2a ) or ( Pde6b ) or ( Pde4d ) or ( Pde5a ) or ( Pde6d ) or ( Pde8b ) or ( Pde3a ) or ( Pde3b ) or ( Pde10a ) or ( Pde6h ) or ( Pde6g ) or ( Pde6a ) or ( Pde9a ) or ( Pde8a ) or ( Pde4a ) or ( Pde11a ) or ( Pde1b ) or ( Pde7b ) or ( Pde4c ) or ( Pde1a ) or ( Pde7a ) or ( Pde1c )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphodiesterase 6C, cGMP specific, cone, alpha prime ) or ( phosphodiesterase 2A, cGMP-stimulated ) or ( phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide ) or ( phosphodiesterase 4D, cAMP specific ) or ( phosphodiesterase 5A, cGMP-specific ) or ( phosphodiesterase 6D, cGMP-specific, rod, delta ) or ( phosphodiesterase 8B ) or ( phosphodiesterase 3A, cGMP inhibited ) or ( phosphodiesterase 3B, cGMP-inhibited ) or ( phosphodiesterase 10A ) or ( phosphodiesterase 6H, cGMP-specific, cone, gamma ) or ( phosphodiesterase 6G, cGMP-specific, rod, gamma ) or ( phosphodiesterase 6A, cGMP-specific, rod, alpha ) or ( phosphodiesterase 9A ) or ( phosphodiesterase 8A ) or ( phosphodiesterase 4A, cAMP specific ) or ( phosphodiesterase 11A ) or ( phosphodiesterase 1B, Ca2+-calmodulin dependent ) or ( phosphodiesterase 7B ) or ( phosphodiesterase 4C, cAMP specific ) or ( phosphodiesterase 1A, calmodulin-dependent ) or ( phosphodiesterase 7A ) or ( phosphodiesterase 1C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.35</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CGMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.22</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LONG__45__CHAIN__45__ENOYL__45__COA__45__HYDRATASE__45__RXN" name="Long-chain-enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Echs1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl Coenzyme A hydratase, short chain, 1, mitochondrial )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.74</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANSENOYL__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREODEHYD__45__RXN" name="L-threonine 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-threonine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.103</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHEAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Asl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__1__46__96__45__RXN" name="4a-hydroxytetrahydrobiopterin dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pcbd2 ) or ( Pcbd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 ) or ( pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.96</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__4__45__OXO__45__4__45__ALPHA__45__HYDROXY__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__4__45__OXO__45__6__45__123__45__TRIHYDROXYPROP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MONOPHENOL__45__MONOOXYGENASE__45__RXN" name="Monophenol monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tyr ) or ( D7Mit19 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosinase ) or ( DNA segment, Chr 7, Massachusetts Institute of Technology 19 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="L__45__DOPA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOPAQUINONE" stoichiometry="1"/>
      <speciesReference species="L__45__DOPA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERPHOSPHA__45__RXN" name="Phosphoserine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Psph )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINATE__45__DEHYDROGENASE__45__UBIQUINONE__45__RXN" name="Succinate dehydrogenase (ubiquinone)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sdhc ) or ( Sdhb ) or ( Sdha ) or ( Sdhd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate dehydrogenase complex, subunit C, integral membrane protein ) or ( succinate dehydrogenase complex, subunit B, iron sulfur (Ip) ) or ( succinate dehydrogenase complex, subunit A, flavoprotein (Fp) ) or ( succinate dehydrogenase complex, subunit D, integral membrane protein )</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donors reaction list</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donor II</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donor III</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.3.5.1</html:p>
<html:p>COFACTOR: __124__Ubiquinols__124__</html:p>
<html:p>COFACTOR: __124__Ubiquinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4OHBENZOATE__45__OCTAPRENYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ubiad1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UbiA prenyltransferase domain containing 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALADENOSYLTRANS__45__RXN" name="Cob(I)alamin adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mmab )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonic aciduria (cobalamin deficiency) type B homolog (human) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COB__45__I__45__ALAMIN" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Succinate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh5a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldhehyde dehydrogenase family 5, subfamily A1 )</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation I</html:p>
<html:p>SUBSYSTEM: glutamate degradation III (via 4-aminobutyrate)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.24</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16ALDOLASE__45__RXN" name="Fructose-bisphosphate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldoa ) or ( Aldoc ) or ( Aldob ) or ( Aldoart1 ) or ( Aldoart2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldolase 1, A isoform ) or ( aldolase 3, C isoform ) or ( aldolase 2, B isoform ) or ( aldolase 1, A isoform, retrogene 1 ) or ( aldolase 1, A isoform, retrogene 2 )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7607" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nt5c3l ) or ( Nt5e ) or ( Nt5c2 ) or ( Nt5c ) or ( Nt5dc3 ) or ( Entpd3 ) or ( Nt5c3 ) or ( Nt5dc1 ) or ( Nt5c1a ) or ( Nt5c1b ) or ( Nt5m ) or ( Nt5dc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase, cytosolic III-like ) or ( 5&apos; nucleotidase, ecto ) or ( 5&apos;-nucleotidase, cytosolic II ) or ( 5&apos;,3&apos;-nucleotidase, cytosolic ) or ( 5&apos;-nucleotidase domain containing 3 ) or ( ectonucleoside triphosphate diphosphohydrolase 3 ) or ( 5&apos;-nucleotidase, cytosolic III ) or ( 5&apos;-nucleotidase domain containing 1 ) or ( 5&apos;-nucleotidase, cytosolic IA ) or ( 5&apos;-nucleotidase, cytosolic IB ) or ( 5&apos;,3&apos;-nucleotidase, mitochondrial ) or ( 5&apos;-nucleotidase domain containing 2 )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ebp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylalkylamine Ca2+ antagonist (emopamil) binding protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4081" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4101" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTOACYLASE__45__RXN" name="Aspartoacylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aspa ) or ( Acy3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartoacylase ) or ( aspartoacylase (aminoacylase) 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__576" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7609" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nt5c3l ) or ( Nt5e ) or ( Nt5c2 ) or ( Nt5c ) or ( Nt5dc3 ) or ( Entpd3 ) or ( Nt5c3 ) or ( Nt5dc1 ) or ( Nt5c1a ) or ( Nt5c1b ) or ( Nt5m ) or ( Nt5dc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase, cytosolic III-like ) or ( 5&apos; nucleotidase, ecto ) or ( 5&apos;-nucleotidase, cytosolic II ) or ( 5&apos;,3&apos;-nucleotidase, cytosolic ) or ( 5&apos;-nucleotidase domain containing 3 ) or ( ectonucleoside triphosphate diphosphohydrolase 3 ) or ( 5&apos;-nucleotidase, cytosolic III ) or ( 5&apos;-nucleotidase domain containing 1 ) or ( 5&apos;-nucleotidase, cytosolic IA ) or ( 5&apos;-nucleotidase, cytosolic IB ) or ( 5&apos;,3&apos;-nucleotidase, mitochondrial ) or ( 5&apos;-nucleotidase domain containing 2 )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1483" name="Ferroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fth1 ) or ( Ftmt ) or ( Cp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferritin heavy chain 1 ) or ( ferritin mitochondrial ) or ( ceruloplasmin )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.16.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FE__43__2" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FE__43__3" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__HYDROXYGLUTARATE__45__DEHYDROGENASE__45__RXN" name="2-hydroxyglutarate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( L2hgdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-2-hydroxyglutarate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__381" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDAZOLONEPROPIONASE__45__RXN" name="Imidazolonepropionase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Amdhd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidohydrolase domain containing 1 )</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.7</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMIMINO__45__L__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPHOSPHOR__45__RXN" name="Guanosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnp1 ) or ( Pnp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase 1 ) or ( purine-nucleoside phosphorylase 2 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.15</html:p>
<html:p>SIDE: RIBOSE__45__1P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYL__45__PHOSPHATASE__45__RXN" name="aryldialkyl phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pon1 ) or ( Pon2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( paraoxonase 1 ) or ( paraoxonase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1826" name="starch phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pygm ) or ( Pygl ) or ( Pygb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( muscle glycogen phosphorylase ) or ( liver glycogen phosphorylase ) or ( brain glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ass1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate synthetase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXBUTYRYL__45__COA__45__DEHYDRATASE__45__RXN" name="3-hydroxybutyryl-CoA dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hadha ) or ( Echs1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit ) or ( enoyl Coenzyme A hydratase, short chain, 1, mitochondrial )</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.55</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTOX__45__RXN" name="Dihydroorotate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhodh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1823" name="&amp;alpha;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Amy2-1 ) or ( Amy2-2 ) or ( Amy1 ) or ( Amy2 ) or ( Gbe1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amylase 2-1, pancreatic ) or ( amylase 2-2, pancreatic ) or ( amylase 1, salivary ) or ( amylase 2, pancreatic ) or ( glucan (1,4-alpha-), branching enzyme 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Large__45__branched__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1825" name="&amp;alpha;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Amy1 ) or ( Gbe1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amylase 1, salivary ) or ( glucan (1,4-alpha-), branching enzyme 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSALDOL__45__RXN" name="Transaldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Taldo1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transaldolase 1 )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: non-oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__CAROTENE__45__1515__45__DIOXYGENASE__45__RXN" name="&amp;beta;-carotene 15,15&apos;-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Bcmo1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-carotene 15,15&apos;-monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.36</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__129" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RETINAL" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__117__45__RXN" name="Dolichyl-phosphate &amp;beta;-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Alg5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase) )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.117</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOLICHOL__45__KINASE__45__RXN" name="Dolichol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dolk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DOLK )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.108</html:p>
<html:p>COFACTOR: CDP</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>SIDE: CDP</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP_TO_GDP_COF_RXN" name="GTP_TO_GDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fpgs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamyl synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACYLMANNOSAMINE__45__KINASE__45__RXN" name="N-acylmannosamine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gne )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.60</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1109" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__841" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4731" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4610" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4732" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4611" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHORYL__45__RXN" name="Phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pygm ) or ( Pygl ) or ( Pygb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( muscle glycogen phosphorylase ) or ( liver glycogen phosphorylase ) or ( brain glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4730" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4604" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4608" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOSYLCERAMIDASE__45__RXN" name="Galactosylceramidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Galc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactosylceramidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__GALACTOSYLCERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM2__45__RXN" name="Cytidine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cda ) or ( Aicda ) or ( Apobec1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase ) or ( activation-induced cytidine deaminase ) or ( apolipoprotein B editing complex 1 )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4737" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4616" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4621" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4144" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tm7sf2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transmembrane 7 superfamily member 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4735" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.215</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4620" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4736" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4614" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4622" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh5 ) or ( Aldh1a3 ) or ( Aldh2 ) or ( Aldh9a1 ) or ( Aldh3b1 ) or ( Aldh3a2 ) or ( Aldh7a1 ) or ( Aldh3a1 ) or ( Aldh1b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 5, testis ) or ( aldehyde dehydrogenase family 1, subfamily A3 ) or ( aldehyde dehydrogenase 2, mitochondrial ) or ( aldehyde dehydrogenase 9, subfamily A1 ) or ( aldehyde dehydrogenase 3 family, member B1 ) or ( aldehyde dehydrogenase family 3, subfamily A2 ) or ( aldehyde dehydrogenase family 7, member A1 ) or ( aldehyde dehydrogenase family 3, subfamily A1 ) or ( aldehyde dehydrogenase 1 family, member B1 )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway III</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway II</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4733" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Bcat1 ) or ( Bcat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched chain aminotransferase 1, cytosolic ) or ( branched chain aminotransferase 2, mitochondrial )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4734" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt1a10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A10 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4619" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIAMIN__45__PYROPHOSPHOKINASE__45__RXN" name="Thiamine pyrophosphokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tpk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamine pyrophosphokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.2</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__64__45__RXN" name="Testosterone 17-&amp;beta;-dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd3b1 ) or ( Hsd17b7 ) or ( Hsd3b3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ) or ( hydroxysteroid (17-beta) dehydrogenase 7 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.64</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TESTOSTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ANDROST4ENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO___124__Fatty__45__Acyl__45__CoA__124___COF_RXN" name="CO-A_TO_|Fatty-Acyl-CoA|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTPDECARB__45__RXN" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Umps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine monophosphate synthetase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.23</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2023" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Trmu )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__THIOURIDINE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__PIPECOLATE__45__OXIDASE__45__RXN" name="L-pipecolate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pipox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pipecolic acid oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__PIPECOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROT__45__RXN" name="Dihydroorotase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cad )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Abat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase )</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROG__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpd2 ) or ( Gpd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol phosphate dehydrogenase 2, mitochondrial ) or ( glycerol-3-phosphate dehydrogenase 1 (soluble) )</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donors reaction list</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERALDEHYDE__45__DEHYDRO__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh2 ) or ( Aldh9a1 ) or ( Aldh3a2 ) or ( Aldh7a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 2, mitochondrial ) or ( aldehyde dehydrogenase 9, subfamily A1 ) or ( aldehyde dehydrogenase family 3, subfamily A2 ) or ( aldehyde dehydrogenase family 7, member A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHD__45__RXN" name="Choline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Chdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline dehydrogenase )</html:p>
<html:p>SUBSYSTEM: choline degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.1</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLPHOSPHATASE__45__RXN" name="Acylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Acyp1 ) or ( Acyp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acylphosphatase 1, erythrocyte (common) type ) or ( acylphosphatase 2, muscle type )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acyl__45__Phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__901" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Xdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.204</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R222__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh2 ) or ( Aldh9a1 ) or ( Aldh3a2 ) or ( Aldh7a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 2, mitochondrial ) or ( aldehyde dehydrogenase 9, subfamily A1 ) or ( aldehyde dehydrogenase family 3, subfamily A2 ) or ( aldehyde dehydrogenase family 7, member A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__371" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__N__45__CHOLOYLTRANSFERASE__45__RXN" name="Glycine N-choloyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Baat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bile acid-Coenzyme A: amino acid N-acyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.65</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="GLYCOCHOLIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__31__45__RXN" name="Aminoadipate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aasdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-aminoadipate-semialdehyde dehydrogenase activity )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.31</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1079" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROSTAGLANDIN__45__I__45__SYNTHASE__45__RXN" name="prostaglandin-I synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ptgis )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostaglandin I2 (prostacyclin) synthase )</html:p>
<html:p>SUBSYSTEM: biosynthesis of prostaglandins</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROSTAGLANDIN__45__H2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__15S__45__69__45__ALPHA__45__EPOXY__45__11__45__ALPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__SYN__45__RXN" name="glutathione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gss )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione synthetase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7644" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sord )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1441" name="ADP-ribose pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nudt9 ) or ( Nudt5 ) or ( Trpm2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nudix (nucleoside diphosphate linked moiety X)-type motif 9 ) or ( nudix (nucleoside diphosphate linked moiety X)-type motif 5 ) or ( transient receptor potential cation channel, subfamily M, member 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE_DIPHOSPHATE_RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLAMINE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Arylamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nat1 ) or ( Aanat ) or ( Nat3 ) or ( Nat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetyltransferase 1 (arylamine N-acetyltransferase) ) or ( aralkylamine N-acetyltransferase ) or ( N-acetyltransferase 3 ) or ( N-acetyltransferase 2 (arylamine N-acetyltransferase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.5</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLARYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BISPHOSPHOGLYCERATE__45__PHOSPHATASE__45__RXN" name="Bisphosphoglycerate phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgam1 ) or ( Pgam2 ) or ( Bpgm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate mutase 1 ) or ( phosphoglycerate mutase 2 ) or ( 2,3-bisphosphoglycerate mutase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_23__45__DIPHOSPHOGLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__146__45__RXN" name="&amp;beta;-1,3-galactosyl-O-glycosyl-glycoprotein &amp;beta;-1,3-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pomgnt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.146</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSYL__45__BETA__45__GALACTOSAMINYL__45__R" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__ETCETERA__45__GALACTOSAMINYL__45__R" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__39__45__RXN" name="Malate dehydrogenase (decarboxylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Me1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malic enzyme 1, NADP(+)-dependent, cytosolic )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.39</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__224__45__RXN" name="Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-&amp;alpha;-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ext1 ) or ( Ext2 ) or ( Extl1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( exostoses (multiple) 1 ) or ( exostoses (multiple) 2 ) or ( exostoses (multiple)-like 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.224</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="beta__45__D__45__glucuronosyl__45____40__1__45____62__4__41____45__N__45__acetyl__45__alpha__45__D__45__glucosaminyl__45__proteoglycan" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__acetyl__45__alpha__45__D__45__glucosaminyl__45____40__1__45____62__4__41____45__beta__45__D__45__glucuronosyl__45____40__1__45____62__4__41____45__N__45__acetyl__45__alpha__45__D__45__glucosaminyl__45__proteoglycan" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__43__45__RXN" name="6-phosphogluconate 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphogluconate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.43</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__339" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__100__45__RXN" name="Protein-S isoprenylcysteine O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Icmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isoprenylcysteine carboxyl methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.100</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__ETC__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__FARNESYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLALANINE__45__4__45__MONOOXYGENASE__45__RXN" name="Phenylalanine 4-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pah ) or ( Pcbd1 ) or ( Paics )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylalanine hydroxylase ) or ( pterin 4 alpha carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 1 ) or ( phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase )</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis II</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I</html:p>
<html:p>SUBSYSTEM: Tyrosine biosynthesis (from phenylalanine)</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.1</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4122" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2R__45__HYDROPEROXY__45__FATTY__45__ACIDS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LANOSTEROL__45__SYNTHASE__45__RXN" name="Lanosterol synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Lss )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA__45__OXIDASE__45__RXN" name="Acyl-CoA oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acox3 ) or ( Acox2 ) or ( Acox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-Coenzyme A oxidase 3, pristanoyl ) or ( acyl-Coenzyme A oxidase 2, branched chain ) or ( acyl-Coenzyme A oxidase 1, palmitoyl )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATESYN__45__RXN" name="Thymidylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tyms )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate synthase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.45</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: DIHYDROFOLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLULOKIN__45__RXN" name="Xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Xylb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylulokinase homolog (H. influenzae) )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOESTER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acot10 ) or ( Acot8 ) or ( Acot2 ) or ( Olah ) or ( Acot7 ) or ( Acot5 ) or ( Acot1 ) or ( Acot3 ) or ( Acot9 ) or ( Acot4 ) or ( Acot6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase 10 ) or ( acyl-CoA thioesterase 8 ) or ( acyl-CoA thioesterase 2 ) or ( oleoyl-ACP hydrolase ) or ( acyl-CoA thioesterase 7 ) or ( acyl-CoA thioesterase 5 ) or ( acyl-CoA thioesterase 1 ) or ( acyl-CoA thioesterase 3 ) or ( acyl-CoA thioesterase 9 ) or ( acyl-CoA thioesterase 4 ) or ( acyl-CoA thioesterase 6 )</html:p>
<html:p>SUBSYSTEM: acyl-CoA hydrolysis</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Saturated__45__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1041" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Itpa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine triphosphatase (nucleoside triphosphate pyrophosphatase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOKINASE__45__RXN" name="Fructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase 1 )</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: sucrose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7657" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adh1 ) or ( Adh4 ) or ( D3Nds9 ) or ( Adh7 ) or ( Adh6b ) or ( Adh5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase 1 (class I) ) or ( alcohol dehydrogenase 4 (class II), pi polypeptide ) or ( DNA segment, Chr 3, Nuffield Department of Surgery 9 ) or ( alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ) or ( alcohol dehydrogenase 6B (class V) ) or ( alcohol dehydrogenase 5 (class III), chi polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7000" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOBUTANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nme3 ) or ( Nme1 ) or ( Nme4 ) or ( Nme2 ) or ( Rp2h ) or ( Nme5 ) or ( Nme7 ) or ( Nme6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( non-metastatic cells 3, protein expressed in ) or ( non-metastatic cells 1, protein (NM23A) expressed in ) or ( non-metastatic cells 4, protein expressed in ) or ( non-metastatic cells 2, protein (NM23B) expressed in ) or ( retinitis pigmentosa 2 homolog (human) ) or ( non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) ) or ( non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) ) or ( non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BILIVERDIN__45__REDUCTASE__45__RXN" name="Biliverdin reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Blvrb ) or ( Blvra )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biliverdin reductase B (flavin reductase (NADPH)) ) or ( biliverdin reductase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.24</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BILIVERDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIRUBIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LONG__45__CHAIN__45__FATTY__45__ACYL__45__COA__45__REDUCTASE__45__RXN" name="Long-chain-fatty-acyl-CoA reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Far2 ) or ( Far1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acyl CoA reductase 2 ) or ( fatty acyl CoA reductase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.50</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Aldehydes__124__" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Acyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DADP_TO_DATP_COF_RXN" name="DADP_TO_DATP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="DADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Abp1 ) or ( Aoc2 ) or ( Aoc3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amiloride binding protein 1 (amine oxidase, copper-containing) ) or ( amine oxidase, copper containing 2 (retina-specific) ) or ( amine oxidase, copper containing 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__18__45__RXN" name="[Myosin light-chain] kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mylk3 ) or ( Mylk2 ) or ( Mylk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myosin light chain kinase 3 ) or ( myosin, light polypeptide kinase 2, skeletal muscle ) or ( myosin, light polypeptide kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.18</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8564" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8563" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__69__45__RXN" name="N-acetylglucosaminylphosphatidylinositol deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pigl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol glycan anchor biosynthesis, class L )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.89</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__452" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__1113" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROSTAGLANDIN__45__D__45__SYNTHASE__45__RXN" name="Prostaglandin-D synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ptgds ) or ( Hpgd ) or ( Ptgds2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostaglandin D2 synthase (brain) ) or ( hydroxyprostaglandin dehydrogenase 15 (NAD) ) or ( prostaglandin D2 synthase 2, hematopoietic )</html:p>
<html:p>SUBSYSTEM: biosynthesis of prostaglandins</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROSTAGLANDIN__45__H2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__15S__45__9__45__ALPHA15__45__DIHYDROXY__45__11__45__O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINEKIN__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Uck2 ) or ( BC016495 ) or ( Uck1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine-cytidine kinase 2 ) or ( cDNA sequence BC016495 ) or ( uridine-cytidine kinase 1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__AMINO__45__ACID__45__OXIDASE__45__RXN" name="D-amino acid oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dao1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-amino acid oxidase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOGLUTREDUCT__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( L2hgdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-2-hydroxyglutarate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.2</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__2__45__HYDROXYGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDASE__45__YEAST__45__RXN" name="Ceramidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Asah3 ) or ( Asah2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 ) or ( N-acylsphingosine amidohydrolase 2 )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.23</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOCERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7668" name="Glycogen (starch) synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gys2 ) or ( Gys1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen synthase 2 ) or ( glycogen synthase 1, muscle )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis (from UDP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.11</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7669" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gbe1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucan (1,4-alpha-), branching enzyme 1 )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis (from UDP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLLACTOSAMINE__45__SYNTHASE__45__RXN" name="N-acetyllactosamine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B4galt2 ) or ( B4galt3 ) or ( B4galt4 ) or ( B4galt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 ) or ( UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 ) or ( UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 ) or ( UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.90</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLAMINE__45__SULFOTRANSFERASE__45__RXN" name="Arylamine sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sult3a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfotransferase family 3A, member 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.3</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZENAMINE__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTSEMIALDEHYDROG__45__RXN" name="Glutamate-5-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh18a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 18 family, member A1 )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1461" name="Coproporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cpox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( coproporphyrinogen oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.3</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__N__45__ACYLTRANSFERASE__45__RXN" name="Glycine N-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Glyat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine-N-acyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.13</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__426" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEME__45__OXYGENASE__45__DECYCLIZING__45__RXN" name="Heme oxygenase (decyclizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hmox2 ) or ( Hmox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heme oxygenase (decycling) 2 ) or ( heme oxygenase (decycling) 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIVERDINE" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSYLCERAMIDASE__45__RXN" name="Glucosylceramidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gba ) or ( Gba2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosidase, beta, acid ) or ( glucosidase beta 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCOSYL_CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__10__46__2__45__RXN" name="Non-specific protein-tyrosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fert2 ) or ( Fgr ) or ( Txk ) or ( Jak2 ) or ( Wee2 ) or ( Zap70 ) or ( Btk ) or ( Abl1 ) or ( Lck ) or ( Ptk6 ) or ( Blk ) or ( Src ) or ( Tnk2 ) or ( Jak3 ) or ( Ptk2 ) or ( Styk1 ) or ( Yes1 ) or ( Syk ) or ( Hck ) or ( Ptk2b ) or ( Lyn ) or ( Srms ) or ( Jak1 ) or ( Abl2 ) or ( Tnk1 ) or ( D8Ertd82e ) or ( Tec ) or ( Itk ) or ( Bmx )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fer (fms/fps related) protein kinase, testis specific 2 ) or ( Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog ) or ( TXK tyrosine kinase ) or ( Janus kinase 2 ) or ( WEE1 homolog 2 (S. pombe) ) or ( zeta-chain (TCR) associated protein kinase ) or ( Bruton agammaglobulinemia tyrosine kinase ) or ( c-abl oncogene 1, receptor tyrosine kinase ) or ( lymphocyte protein tyrosine kinase ) or ( PTK6 protein tyrosine kinase 6 ) or ( B lymphoid kinase ) or ( Rous sarcoma oncogene ) or ( tyrosine kinase, non-receptor, 2 ) or ( Janus kinase 3 ) or ( PTK2 protein tyrosine kinase 2 ) or ( serine/threonine/tyrosine kinase 1 ) or ( Yamaguchi sarcoma viral (v-yes) oncogene homolog 1 ) or ( spleen tyrosine kinase ) or ( hemopoietic cell kinase ) or ( PTK2 protein tyrosine kinase 2 beta ) or ( Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ) or ( src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites ) or ( Janus kinase 1 ) or ( v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) ) or ( tyrosine kinase, non-receptor, 1 ) or ( DNA segment, Chr 8, ERATO Doi 82, expressed ) or ( cytoplasmic tyrosine kinase, Dscr28C related (Drosophila) ) or ( IL2-inducible T-cell kinase ) or ( BMX non-receptor tyrosine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.10.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFINOALANINE__45__DECARBOXYLASE__45__RXN" name="Sulfinoalanine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Csad )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine sulfinic acid decarboxylase )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation VI</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.29</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOTAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSMANMUT__45__RXN" name="Phosphomannomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pmm1 ) or ( Pmm2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomannomutase 1 ) or ( phosphomannomutase 2 )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__37" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh2 ) or ( Aldh9a1 ) or ( Aldh3a2 ) or ( Aldh7a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 2, mitochondrial ) or ( aldehyde dehydrogenase 9, subfamily A1 ) or ( aldehyde dehydrogenase family 3, subfamily A2 ) or ( aldehyde dehydrogenase family 7, member A1 )</html:p>
<html:p>SUBSYSTEM: putrescine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__30" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__35" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__34" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Arg2 ) or ( Arg1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase type II ) or ( arginase 1, liver )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DESULFOHEPARIN__45__SULFOTRANSFERASE__45__RXN" name="Desulfoheparin sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ndst1 ) or ( Ndst4 ) or ( Ndst2 ) or ( Ndst3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 ) or ( N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4 ) or ( N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 ) or ( N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.8</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__DESULFOHEPARIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEPARIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7682" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Xdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYACID__45__OXOACID__45__TRANSHYDROGENASE__45__RXN" name="Hydroxyacid-oxoacid transhydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Adhfe1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase, iron containing, 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.24</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1843" stoichiometry="1"/>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="R__45__2__45__HYDROXYGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPRIBOSYLTRAN__45__RXN" name="Adenine phosphoribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aprt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenine phosphoribosyl transferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.7</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHINE__45__DEHYDROGENASE__45__RXN" name="Xanthine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Xdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPRIBOSYLTRAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hprt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine guanine phosphoribosyl transferase 1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R301__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adpgk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-dependent glucokinase )</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.147</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE_TO_L__45__ALPHA__45__ALANINE_COF_RXN" name="PYRUVATE_TO_L-ALPHA-ALANINE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__12__45__RXN" name="cGMP-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Prkg1 ) or ( Aurka ) or ( Prkg2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein kinase, cGMP-dependent, type I ) or ( aurora kinase A ) or ( protein kinase, cGMP-dependent, type II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROSPHINGANINE__45__REDUCTASE__45__RXN" name="3-dehydrosphinganine reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Kdsr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-ketodihydrosphingosine reductase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.102</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDROSPHINGANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__52__45__RXN" name="Diphosphoinositol-polyphosphate diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nudt10 ) or ( Nudt4 ) or ( Nudt11 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nudix (nucleoside diphosphate linked moiety X)-type motif 10 ) or ( nudix (nucleoside diphosphate linked moiety X)-type motif 4 ) or ( nudix (nucleoside diphosphate linked moiety X)-type motif 11 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.52</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Diphospho__45__myo__45__inositol__45__polyphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Myo__45__inositol__45__polyphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBPSYN__45__RXN" name="carbamoyl-phosphate synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cps1 ) or ( Cad )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbamoyl-phosphate synthetase 1 ) or ( carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FARNESYLTRANSTRANSFERASE__45__RXN" name="Farnesyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fntb ) or ( Ggps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyltransferase, CAAX box, beta ) or ( geranylgeranyl diphosphate synthase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.29</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOHEMEFERROCHELAT__45__RXN" name="Ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fech )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferrochelatase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARAGHYD__45__RXN" name="Asparaginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( A530050D06Rik ) or ( Asrgl1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RIKEN cDNA A530050D06 gene ) or ( asparaginase like 1 )</html:p>
<html:p>SUBSYSTEM: superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine.</html:p>
<html:p>SUBSYSTEM: asparagine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOHMETRANS__45__RXN" name="Glycine hydroxymethyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Shmt2 ) or ( Shmt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase 2 (mitochondrial) ) or ( serine hydroxymethyltransferase 1 (soluble) )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis</html:p>
<html:p>SUBSYSTEM: Serine degradation II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.1</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDE__45__KINASE__45__RXN" name="Ceramide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Agk ) or ( Cerk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acylglycerol kinase ) or ( ceramide kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.138</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__502" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREONINE__45__ALDOLASE__45__RXN" name="Threonine aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tha1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine aldolase 1 )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>SIDE: ACETALD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__23__45__DIOXYGENASE__45__RXN" name="Tryptophan 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tdo2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 2,3-dioxygenase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.11</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMYLKYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTURIDYLYLTRANS__45__RXN" name="UDP-glucose--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Galt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactose-1-phosphate uridyl transferase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD__45__PYROPHOSPHATASE__45__RXN" name="FAD pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Enpp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleotide pyrophosphatase/phosphodiesterase 1 )</html:p>
<html:p>SUBSYSTEM: riboflavin, FMN and FAD transformations</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.18</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__11__45__RXN" name="cAMP-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aurka ) or ( Prkaca ) or ( Prkacb ) or ( Prkar2a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aurora kinase A ) or ( protein kinase, cAMP dependent, catalytic, alpha ) or ( protein kinase, cAMP dependent, catalytic, beta ) or ( protein kinase, cAMP dependent regulatory, type II alpha )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACYLGLUCOSAMINE__45__2__45__EPIMERASE__45__RXN" name="N-acylglucosamine 2-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Renbp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( renin binding protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__270" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1109" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__FORMYLGLUTATHIONE__45__HYDROLASE__45__RXN" name="S-formylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Esd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( esterase D/formylglutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__22__45__RXN" name="Cyclin-dependent kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ccrk ) or ( Cdkl5 ) or ( Aurka ) or ( Rage ) or ( Cdk7 ) or ( Mak ) or ( Cdk6 ) or ( Cdk5 ) or ( Crkrs ) or ( Pctk1 ) or ( Cdk5r1 ) or ( Cdk10 ) or ( Cdk5r2 ) or ( Pftk1 ) or ( Cdkl4 ) or ( Cdk4 ) or ( Cdk8 ) or ( Cdk3 ) or ( Pctk3 ) or ( Pftk2 ) or ( Cdkl2 ) or ( Cdk9 ) or ( Cdkl1 ) or ( Cdc2l1 ) or ( Cdkl3 ) or ( Cdc2l5 ) or ( Cdk2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cell cycle related kinase ) or ( cyclin-dependent kinase-like 5 ) or ( aurora kinase A ) or ( renal tumor antigen ) or ( cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) ) or ( male germ cell-associated kinase ) or ( cyclin-dependent kinase 6 ) or ( cyclin-dependent kinase 5 ) or ( Cdc2-related kinase, arginine/serine-rich ) or ( PCTAIRE-motif protein kinase 1 ) or ( cyclin-dependent kinase 5, regulatory subunit (p35) 1 ) or ( cyclin-dependent kinase (CDC2-like) 10 ) or ( cyclin-dependent kinase 5, regulatory subunit 2 (p39) ) or ( PFTAIRE protein kinase 1 ) or ( cyclin-dependent kinase-like 4 ) or ( cyclin-dependent kinase 4 ) or ( cyclin-dependent kinase 8 ) or ( cyclin-dependent kinase 3 ) or ( PCTAIRE-motif protein kinase 3 ) or ( PFTAIRE protein kinase 2 ) or ( cyclin-dependent kinase-like 2 (CDC2-related kinase) ) or ( cyclin-dependent kinase 9 (CDC2-related kinase) ) or ( cyclin-dependent kinase-like 1 (CDC2-related kinase) ) or ( cell division cycle 2-like 1 ) or ( cyclin-dependent kinase-like 3 ) or ( cell division cycle 2-like 5 (cholinesterase-related cell division controller) ) or ( cyclin-dependent kinase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.22</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__2__45__HYDROXY__45__ACID__45__OXIDASE__45__RXN" name="(S)-2-hydroxy-acid oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hao2 ) or ( Hao3 ) or ( Hao1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacid oxidase 2, kidney ) or ( hydroxyacid oxidase (glycolate oxidase) 3 ) or ( hydroxyacid oxidase 1, liver )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__2__45__Hydroxyacids1__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITDEH__45__RXN" name="Isocitrate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Idh2 ) or ( Idh1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate dehydrogenase 2 (NADP+), mitochondrial ) or ( isocitrate dehydrogenase 1 (NADP+), soluble )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THRESYN__45__RXN" name="Threonine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Thnsl1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine synthase-like 1 (bacterial) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINESTERASE__45__RXN" name="Cholinesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Bche )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( butyrylcholinesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acylcholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYGLUTAMATE__45__AMINOTRANSFERASE__45__RXN" name="4-hydroxyglutamate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Got1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate oxaloacetate transaminase 1, soluble )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.1</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__4__45__HYDROXY__45__2__45__KETO__45__GLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PAPS_TO_PAP_COF_RXN" name="PAPS_TO_PAP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SIALATE__45__O__45__ACETYLESTERASE__45__RXN" name="Sialate O-acetylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Siae )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sialic acid acetylesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.53</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__O__45__ACETYLNEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLNEURAMINATE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Agpat6 ) or ( Agpat5 ) or ( Agpat9 ) or ( Agpat2 ) or ( Agpat4 ) or ( Lycat ) or ( Agpat7 ) or ( Agpat3 ) or ( Agpat1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) ) or ( 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) ) or ( 1-acylglycerol-3-phosphate O-acyltransferase 9 ) or ( 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) ) or ( 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) ) or ( lysocardiolipin acyltransferase ) or ( 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta) ) or ( 1-acylglycerol-3-phosphate O-acyltransferase 3 ) or ( 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha) )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.51</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCOKINASE__45__RXN" name="Fucokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fuk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fucokinase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis II (from L-fucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.52</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__488" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA__45__CARBOXYLTRANSFER__45__RXN" name="Acetyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acaca ) or ( Acacb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-Coenzyme A carboxylase alpha ) or ( acetyl-Coenzyme A carboxylase beta )</html:p>
<html:p>SUBSYSTEM: fatty acid biosynthesis - initial steps I</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Bcat1 ) or ( Bcat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched chain aminotransferase 1, cytosolic ) or ( branched chain aminotransferase 2, mitochondrial )</html:p>
<html:p>SUBSYSTEM: glutamate biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: glutamate and glutamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__211__45__RXN" name="Long-chain-3-hydroxyacyl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hadha )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.211</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOSYLCERAMIDE__45__SULFOTRANSFERASE__45__RXN" name="Galactosylceramide sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gal3st1 ) or ( Gal3st3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactose-3-O-sulfotransferase 1 ) or ( galactose-3-O-sulfotransferase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.11</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__GALACTOSYLCERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSYLCERAMIDE__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__11__45__RXN" name="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cdipt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.11</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5467" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pigm ) or ( Alg12 ) or ( Alg3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol glycan anchor biosynthesis, class M ) or ( asparagine-linked glycosylation 12 homolog (yeast, alpha-1,6-mannosyltransferase) ) or ( asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase) )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
      <speciesReference species="CPD__45__5165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__244__45__RXN" name="acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B4galnt4 ) or ( B4galnt3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-1,4-N-acetyl-galactosaminyl transferase 4 ) or ( beta-1,4-N-acetyl-galactosaminyl transferase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.244</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8944" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8945" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__PALMITOYLTRANSFERASE__45__RXN" name="Carnitine O-palmitoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cpt1b ) or ( Cpt2 ) or ( Cpt1a ) or ( Cpt1c )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine palmitoyltransferase 1b, muscle ) or ( carnitine palmitoyltransferase 2 ) or ( carnitine palmitoyltransferase 1a, liver ) or ( carnitine palmitoyltransferase 1c )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.21</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PALMITYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__419" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__GLUCURONID__45__RXN" name="&amp;beta;-glucuronidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Afp ) or ( Gusb ) or ( Kl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha fetoprotein ) or ( glucuronidase, beta ) or ( klotho )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide degradation</html:p>
<html:p>SUBSYSTEM: Vitamin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__D__45__Glucuronides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5463" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pigm ) or ( Alg12 ) or ( Alg3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol glycan anchor biosynthesis, class M ) or ( asparagine-linked glycosylation 12 homolog (yeast, alpha-1,6-mannosyltransferase) ) or ( asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase) )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5161" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5162" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxyisobutyrate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hibadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyisobutyrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.31</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BHBDCLOS__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hadh ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacyl-Coenzyme A dehydrogenase ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__7__45__RXN" name="(&amp;alpha;-N-acetyl-neuraminyl-2,3-&amp;beta;-galactosyl-1,3)-N- acetylgalactosaminide &amp;alpha;-2,6-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( St6galnac4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.7</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__ETCETERA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__DIACETYLNEURAMINYL__45__23__45__BETA__45__D__45__ETC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOSIDE__45__2__45__L__45__FUCOSYLTRANSFERASE__45__RXN" name="Galactoside 2-L-fucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fut1 ) or ( Fut2 ) or ( Sec1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fucosyltransferase 1 ) or ( fucosyltransferase 2 ) or ( secretory blood group 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.69</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__R" stoichiometry="1"/>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__L__45__FUCOSYL__45__12__45__BETA__45__D__45__GALACTOSYL__45__R" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLMALONYL__45__COA__45__MUT__45__RXN" name="Methylmalonyl-CoA mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mut )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonyl-Coenzyme A mutase )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: isoleucine degradation</html:p>
<html:p>SUBSYSTEM: 2-oxobutanoate degradation I</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Protein__45__Dithiols__124___TO___124__Protein__45__Disulfides__124___COF_RXN" name="|Protein-Dithiols|_TO_|Protein-Disulfides|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Dithiols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXYLATE__45__REDUCTASE__45__NADP__43____45__RXN" name="Glyoxylate reductase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Grhpr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxylate reductase/hydroxypyruvate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__45__45__RXN" name="2-hydroxyacylsphingosine 1-&amp;beta;-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugt8a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP galactosyltransferase 8A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
      <speciesReference species="_2__45__2__45__HYDROXYACYLSPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__BETA__45__D__45__GALACTOSYL__45__2__45__2__45__HYDROXYACYLS" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__11__45__RXN" name="1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Plcd4 ) or ( Plce1 ) or ( Plch1 ) or ( Plcb1 ) or ( Plch2 ) or ( Plcd1 ) or ( Plcb3 ) or ( Plcb2 ) or ( Plcg1 ) or ( Plcd3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase C, delta 4 ) or ( phospholipase C, epsilon 1 ) or ( phospholipase C, eta 1 ) or ( phospholipase C, beta 1 ) or ( phospholipase C, eta 2 ) or ( phospholipase C, delta 1 ) or ( phospholipase C, beta 3 ) or ( phospholipase C, beta 2 ) or ( phospholipase C, gamma 1 ) or ( phospholipase C, delta 3 )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5470" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Alg6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase) )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5168" stoichiometry="1"/>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5169" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__D__45__RXN" name="Phospholipase D" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pld2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase D2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITRATE__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Isocitrate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 4933405O20Rik ) or ( Idh3a ) or ( Idh3g ) or ( Idh3b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RIKEN cDNA 4933405O20 gene ) or ( isocitrate dehydrogenase 3 (NAD+) alpha ) or ( isocitrate dehydrogenase 3 (NAD+), gamma ) or ( isocitrate dehydrogenase 3 (NAD+) beta )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.41</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5471" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Alg6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine-linked glycosylation 6 homolog (yeast, alpha-1,3,-glucosyltransferase) )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
      <speciesReference species="CPD__45__5169" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5170" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE1EPIM__45__RXN" name="ALDOSE-1-EPIMERASE" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Galm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactose mutarotase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__223__45__RXN" name="Glucuronyl-galactosyl-proteoglycan 4-&amp;alpha;-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gcnt2 ) or ( Gcnt3 ) or ( Gcnt1 ) or ( A4gnt ) or ( Extl2 ) or ( B3gnt7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosaminyl (N-acetyl) transferase 2, I-branching enzyme ) or ( glucosaminyl (N-acetyl) transferase 3, mucin type ) or ( glucosaminyl (N-acetyl) transferase 1, core 2 ) or ( alpha-1,4-N-acetylglucosaminyltransferase ) or ( exostoses (multiple)-like 2 ) or ( UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.223</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="beta__45__D__45__glucuronosyl__45____40__1__45____62__3__41____45__beta__45__D__45__galactosyl__45____40__1__45____62__3__41____45__beta__45__D__45__galactosyl__45____40__1__45____62__4__41____45__beta__45__D__45__xylosyl__45__proteoglycan" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="alpha__45__N__45__acetyl__45__D__45__glucosaminyl__45____40__1__45____62__4__41____45__beta__45__D__45__glucuronosyl__45____40__1__45____62__3__41____45__beta__45__D__45__galactosyl__45____40__1__45____62__3__41____45__beta__45__D__45__galactosyl__45____40__1__45____62__4__41____45__beta__45__D__45__xylosyl__45__proteoglycan" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="YEAST__45__SQUALENE__45__RXN" name="Farnesyl-diphosphate farnesyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdft1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl diphosphate farnesyl transferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOPRIBOTRANS__45__RXN" name="Nicotinate-nucleotide pyrophosphorylase (carboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Qprt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinolinate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.19</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINEPHOSPHOTRANSFERASE__45__RXN" name="Ethanolaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( D5Wsu178e ) or ( Cept1 ) or ( Pigf )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA segment, Chr 5, Wayne State University 178, expressed ) or ( choline/ethanolaminephosphotransferase 1 ) or ( phosphatidylinositol glycan anchor biosynthesis, class F )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.1</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CALCIDIOL__45__1__45__MONOOXYGENASE__45__RXN" name="Calcidiol 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp27b1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 27, subfamily b, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.13</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CALCIDIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CALCITRIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__P__45__OR__45__NOP_TO_NADH__45__P__45__OR__45__NOP_COF_RXN" name="NAD-P-OR-NOP_TO_NADH-P-OR-NOP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Txndc16 ) or ( Txnl4b ) or ( Nhlrc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thioredoxin domain containing 16 ) or ( thioredoxin-like 4B ) or ( NHL repeat containing 2 )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: LIPOIC__45__ACID</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>SIDE: CPD__45__296</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__296" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOIC__45__ACID" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__763" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__17__45__RXN" name="L-serine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sdsl ) or ( Sds )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine dehydratase-like ) or ( serine dehydratase )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: L-serine degradation</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__REDUCTASE__45__RXN" name="Aldehyde reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1b8 ) or ( Akr1b3 ) or ( Akr1b7 ) or ( Aldr3 ) or ( Aldr2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1, member B8 ) or ( aldo-keto reductase family 1, member B3 (aldose reductase) ) or ( aldo-keto reductase family 1, member B7 ) or ( aldehyde reductase 3 ) or ( aldehyde reductase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.21</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALDITOL" stoichiometry="1"/>
      <speciesReference species="__124__Alditols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALDOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAM__45__RXN" name="Phosphoserine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Psat1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase 1 )</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__134__45__RXN" name="1D-myo-inositol-tetrakisphosphate 1-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Itpk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol 1,3,4-triphosphate 5/6 kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.134</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__178" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSGLYPHOS__45__RXN" name="Phosphoglycerate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgk1 ) or ( Pgk2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate kinase 1 ) or ( phosphoglycerate kinase 2 )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7839" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Echs1 ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl Coenzyme A hydratase, short chain, 1, mitochondrial ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__23__45__RXN" name="Acylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Lipe ) or ( Mgll )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipase, hormone sensitive ) or ( monoglyceride lipase )</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Fatty__45__Acids__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__409" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHONDROITIN__45__6__45__SULFOTRANSFERASE__45__RXN" name="Chondroitin 6-sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Chst3 ) or ( Chst7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbohydrate (chondroitin 6/keratan) sulfotransferase 3 ) or ( carbohydrate (N-acetylglucosamino) sulfotransferase 7 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.17</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHONDROITIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHONDROITIN__45__6__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7835" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Decr1 ) or ( Decr2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dienoyl CoA reductase 1, mitochondrial ) or ( 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__trans__45__4__45__cis__45__dienoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7836" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dci ) or ( Peci ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dodecenoyl-Coenzyme A delta isomerase (3,2 trans-enoyl-Coenyme A isomerase) ) or ( peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTPSYN__45__RXN" name="CTP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ctps ) or ( Ctps2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine 5&apos;-triphosphate synthase ) or ( cytidine 5&apos;-triphosphate synthase 2 )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7838" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cis__45__2__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__GLN__45__RXN" name="NAD(+) synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nadsyn1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD synthetase 1 )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__5__45__RXN" name="Betaine--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Bhmt2 ) or ( Bhmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( betaine-homocysteine methyltransferase 2 ) or ( betaine-homocysteine methyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="BETAINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THF_TO_METHYLENE__45__THF_COF_RXN" name="THF_TO_METHYLENE-THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLTHFGLUSYNTH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fpgs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamyl synthetase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__70__45__RXN" name="Sterol 14-demethylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp51 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 51 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OBTUSIFOLIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7001" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnp1 ) or ( Pnp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine-nucleoside phosphorylase 1 ) or ( purine-nucleoside phosphorylase 2 )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: INOSINE</html:p>
<html:p>SIDE: HYPOXANTHINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARSENATE" stoichiometry="1"/>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__10__46__99__46__2__45__RXN" name="Ribosyldihydronicotinamide dehydrogenase (quinone)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nqo2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P)H dehydrogenase, quinone 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.99.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7229" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7230" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__35618" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: creatine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CREATINE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CREATININE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5234" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Shmt2 ) or ( Shmt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase 2 (mitochondrial) ) or ( serine hydroxymethyltransferase 1 (soluble) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLO__45__THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5442" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh1a3 ) or ( Aldh3b1 ) or ( Aldh3a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family 1, subfamily A3 ) or ( aldehyde dehydrogenase 3 family, member B1 ) or ( aldehyde dehydrogenase family 3, subfamily A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__ACCEPTOR" stoichiometry="1"/>
      <speciesReference species="_3__45__INDOLYLGLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCOLATE" stoichiometry="1"/>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETO__45__ADIPATE__45__DEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ogdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxoglutarate dehydrogenase (lipoamide) )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>SUBSYSTEM: 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2K__45__ADIPATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5445" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh1a3 ) or ( Aldh3b1 ) or ( Aldh3a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family 1, subfamily A3 ) or ( aldehyde dehydrogenase 3 family, member B1 ) or ( aldehyde dehydrogenase family 3, subfamily A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__INDOLEGLYOXAL" stoichiometry="1"/>
      <speciesReference species="OXIDIZED__45__ACCEPTOR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYOXYLATE" stoichiometry="1"/>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BILE__45__SALT__45__SULFOTRANSFERASE__45__RXN" name="Bile-salt sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sult2a1 ) or ( Sult2a2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 ) or ( sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.14</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAUROLITHOCHOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAUROLITHOCHOLATE__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__1__45__RXN" name="Nicotinamide-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nmnat1 ) or ( Nmnat3 ) or ( Nmnat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinamide nucleotide adenylyltransferase 1 ) or ( nicotinamide nucleotide adenylyltransferase 3 ) or ( nicotinamide nucleotide adenylyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis III</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway III</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Acceptor__124___TO___124__Donor__45__H2__124___COF_RXN" name="|Acceptor|_TO_|Donor-H2|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__64__45__RXN" name="Glutamine--phenylpyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ccbl1 ) or ( Ccbl2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine conjugate-beta lyase 1 ) or ( cysteine conjugate-beta lyase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.64</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="_2__45__KETO__45__GLUTARAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__72__45__RXN" name="Methylsterol monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc4mol )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C4-methyl oxidase-like )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__5ALPHA__45__CHOLEST__45__7__45__EN__45__3BET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5847" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMP__45__DEHYDROG__45__RXN" name="IMP dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Impdh2 ) or ( Impdh1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine 5&apos;-phosphate dehydrogenase 2 ) or ( inosine 5&apos;-phosphate dehydrogenase 1 )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.205</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XMPXAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nt5e ) or ( Nt5c2 ) or ( Nt5c1b ) or ( Nt5dc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos; nucleotidase, ecto ) or ( 5&apos;-nucleotidase, cytosolic II ) or ( 5&apos;-nucleotidase, cytosolic IB ) or ( 5&apos;-nucleotidase domain containing 2 )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__40__45__RXN" name="(R)-3-amino-2-methylpropionate--pyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Agxt2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alanine-glyoxylate aminotransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.40</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__471" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5240" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Shmt2 ) or ( Shmt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase 2 (mitochondrial) ) or ( serine hydroxymethyltransferase 1 (soluble) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOL__45__OXIDASE__45__RXN" name="Thiol oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Qsox2 ) or ( Qsox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quiescin Q6 sulfhydryl oxidase 2 ) or ( quiescin Q6 sulfhydryl oxidase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.3.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__38__amp__59__apos__59__C__40__R__41__SH" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__38__amp__59__apos__59__C__40__R__41__S__45__S__40__R__41__CR__38__amp__59__apos__59__" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__170" name="Aromatic-L-amino-acid decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ddc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dopa decarboxylase )</html:p>
<html:p>SUBSYSTEM: biosynthesis of serotonin and melatonin</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__HYDROXY__45__TRYPTOPHAN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SEROTONIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__47__45__RXN" name="2-acetyl-1-alkylglycerophosphocholine esterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pafah2 ) or ( A530050D06Rik ) or ( Pla2g7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( platelet-activating factor acetylhydrolase 2 ) or ( RIKEN cDNA A530050D06 gene ) or ( phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.47</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__ALKYL__45__2__45__ACETYL__45__SN__45__GLYCERO__45__3__45__PHOSPHOCHO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="_1__45__ALKYL__45__SN__45__GLYCERO__45__3__45__PHOSPHOCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3PGAREARR__45__RXN" name="Phosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgam1 ) or ( Pgam2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate mutase 1 ) or ( phosphoglycerate mutase 2 )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLNEURAMINATE__45__MONOOXYGENASE__45__RXN" name="CMP-N-acetylneuraminate monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cmah )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine monophospho-N-acetylneuraminic acid hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYLNEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__273" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOPHOSPHORYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pygm ) or ( Pygl ) or ( Pygb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( muscle glycogen phosphorylase ) or ( liver glycogen phosphorylase ) or ( brain glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMINE__45__SYNTHASE__45__RXN" name="Spermine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sms )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermine synthase )</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis II</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEAMINASE__45__RXN" name="AMP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ampd2 ) or ( Ampd1 ) or ( Ampd3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine monophosphate deaminase 2 (isoform L) ) or ( adenosine monophosphate deaminase 1 (isoform M) ) or ( AMP deaminase 3 )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLTRANSFER__45__RXN" name="Amino-acid N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nags )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglutamate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTOCHROME__45__C__45__OXIDASE__45__RXN" name="Cytochrome-c oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cox6a1 ) or ( Cox7b ) or ( Cox7c ) or ( Cox17 ) or ( Cox8c ) or ( Cox6a2 ) or ( Ndufa4l2 ) or ( Cox7a2l ) or ( mt-Co1 ) or ( Cox8a ) or ( Cox6c ) or ( Cox7a2 ) or ( Cox6b1 ) or ( Cox5b ) or ( Cox4i1 ) or ( Cox5a ) or ( Tspan5 ) or ( Cox8b ) or ( Cox7a1 ) or ( Cox6b2 ) or ( Cox7b2 ) or ( mt-Co3 ) or ( Cox4i2 ) or ( mt-Co2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome c oxidase, subunit VI a, polypeptide 1 ) or ( cytochrome c oxidase subunit VIIb ) or ( cytochrome c oxidase, subunit VIIc ) or ( cytochrome c oxidase, subunit XVII assembly protein homolog (yeast) ) or ( cytochrome c oxidase, subunit VIIIc ) or ( cytochrome c oxidase, subunit VI a, polypeptide 2 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 ) or ( cytochrome c oxidase subunit VIIa polypeptide 2-like ) or ( cytochrome c oxidase I, mitochondrial ) or ( cytochrome c oxidase, subunit VIIIa ) or ( cytochrome c oxidase, subunit VIc ) or ( cytochrome c oxidase, subunit VIIa 2 ) or ( cytochrome c oxidase, subunit VIb polypeptide 1 ) or ( cytochrome c oxidase, subunit Vb ) or ( cytochrome c oxidase subunit IV isoform 1 ) or ( cytochrome c oxidase, subunit Va ) or ( tetraspanin 5 ) or ( cytochrome c oxidase, subunit VIIIb ) or ( cytochrome c oxidase, subunit VIIa 1 ) or ( cytochrome c oxidase subunit VIb polypeptide 2 ) or ( cytochrome c oxidase subunit VIIb2 ) or ( cytochrome c oxidase III, mitochondrial ) or ( cytochrome c oxidase subunit IV isoform 2 ) or ( cytochrome c oxidase II, mitochondrial )</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donor II</html:p>
<html:p>PROTEIN_CLASS: 1.9.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2363" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2361" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPISOM__45__RXN" name="Mannose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mpi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannose phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: mannose degradation</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCMP__45__DEAMINASE__45__RXN" name="dCMP deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dctd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dCMP deaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__NUCLEOTID__45__RXN" name="5&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nt5e ) or ( Nt5c3l ) or ( Nt5c2 ) or ( Nt5c ) or ( Nt5dc3 ) or ( Nt5c3 ) or ( Entpd3 ) or ( Nt5dc1 ) or ( Nt5c1b ) or ( Nt5c1a ) or ( Nt5dc2 ) or ( Nt5m )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos; nucleotidase, ecto ) or ( 5&apos;-nucleotidase, cytosolic III-like ) or ( 5&apos;-nucleotidase, cytosolic II ) or ( 5&apos;,3&apos;-nucleotidase, cytosolic ) or ( 5&apos;-nucleotidase domain containing 3 ) or ( 5&apos;-nucleotidase, cytosolic III ) or ( ectonucleoside triphosphate diphosphohydrolase 3 ) or ( 5&apos;-nucleotidase domain containing 1 ) or ( 5&apos;-nucleotidase, cytosolic IB ) or ( 5&apos;-nucleotidase, cytosolic IA ) or ( 5&apos;-nucleotidase domain containing 2 ) or ( 5&apos;,3&apos;-nucleotidase, mitochondrial )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANIDINOACETATE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Guanidinoacetate N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gamt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanidinoacetate methyltransferase )</html:p>
<html:p>SUBSYSTEM: creatine biosynthesis</html:p>
<html:p>SUBSYSTEM: glycine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.2</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANIDOACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CREATINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__2__45__RXN" name="Procollagen-proline,2-oxoglutarate-4-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( P4ha2 ) or ( P4ha3 ) or ( P4ha1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide ) or ( procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III ) or ( procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.2</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROCOLLAGEN__45__L__45__PROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6321" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADNUCLEOSID__45__RXN" name="NAD(+) nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cd38 ) or ( Bst1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CD38 antigen ) or ( bone marrow stromal cell antigen 1 )</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.5</html:p>
<html:p>SIDE: ADENOSINE_DIPHOSPHATE_RIBOSE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
      <speciesReference species="ADENOSINE_DIPHOSPHATE_RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__REDUCT__45__NADPH__45__RXN" name="Glutathione reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gsr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione reductase )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions II</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Shmt2 ) or ( Shmt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase 2 (mitochondrial) ) or ( serine hydroxymethyltransferase 1 (soluble) )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__4__46__1__45__RXN" name="Vitamin-K-epoxide reductase (warfarin-sensitive)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Vkorc1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( vitamin K epoxide reductase complex, subunit 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.4.1</html:p>
<html:p>COFACTOR: DITHIOTHREITOL</html:p>
<html:p>COFACTOR: OXIDIZED__45__DITHIOTHREITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__METHYL__45__3__45__PHYTYL__45__14__45__NAPHTHOQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_23__45__EPOXY__45__23__45__DIHYDRO__45__2__45__METHYL__45__14__45__NAPHTHOQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPONTPRO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: proline biosynthesis V (from arginine)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation (arginase pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45____45__OXO__45__ACID__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Oat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acid__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__NAD__43____45__RXN" name="DNA ligase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lig3 ) or ( Bdp1 ) or ( Lig4 ) or ( Lig1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ligase III, DNA, ATP-dependent ) or ( B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB ) or ( ligase IV, DNA, ATP-dependent ) or ( ligase I, DNA, ATP-dependent )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MEVALONATE__45__KINASE__45__RXN" name="Mevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mvk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mevalonate kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.36</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYKIN__45__RXN" name="Diacylglycerol kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dgkb ) or ( Dgki ) or ( Agk ) or ( Dgkd ) or ( Dgkq ) or ( Dgke ) or ( Dgkh ) or ( Dgkg ) or ( Sphk2 ) or ( Dgkz ) or ( Dgka )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diacylglycerol kinase, beta ) or ( diacylglycerol kinase, iota ) or ( acylglycerol kinase ) or ( diacylglycerol kinase, delta ) or ( diacylglycerol kinase, theta ) or ( diacylglycerol kinase, epsilon ) or ( diacylglycerol kinase, eta ) or ( diacylglycerol kinase, gamma ) or ( sphingosine kinase 2 ) or ( diacylglycerol kinase zeta ) or ( diacylglycerol kinase, alpha )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.107</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45____45__PYRUVATE__45__AMINOTRANSFERASE__45__RXN" name="Serine--pyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Agxt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alanine-glyoxylate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.51</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__3__46__2__46__10__45__RXN" name="Soluble epoxide hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ephx1 ) or ( Abhd6 ) or ( Ephx2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( epoxide hydrolase 1, microsomal ) or ( abhydrolase domain containing 6 ) or ( epoxide hydrolase 2, cytoplasmic )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.10</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__epoxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__glycols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOSULFATE__45__SULFURTRANSFERASE__45__RXN" name="Thiosulfate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tst )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiosulfate sulfurtransferase, mitochondrial )</html:p>
<html:p>SUBSYSTEM: thiosulfate disproportionation III (rhodanese)</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.1</html:p>
<html:p>SIDE: HCN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="1"/>
      <speciesReference species="HCN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="HSCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BTUR2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mmab )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonic aciduria (cobalamin deficiency) type B homolog (human) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="COBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__62__45__RXN" name="mRNA (2&apos;-O-methyladenosine-N6-)-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mettl3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methyltransferase-like 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.62</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="M__40__7__41__G__40__5__38__amp__59__apos__59____41__PPPAM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="M__40__7__41__G__40__5__38__amp__59__apos__59____41__PPPM__40__6__41__AM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__SYNTHASE__45__RXN" name="Cystathionine &amp;beta;-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cbs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: homocysteine degradation</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__4__45__RXN" name="&amp;beta;-galactoside &amp;alpha;-2,3-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( St3gal4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ST3 beta-galactoside alpha-2,3-sialyltransferase 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.4</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GALACTOSAMINY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__ETCETERA__45__GALACT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACNEULY__45__RXN" name="N-acetylneuraminate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Npl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylneuraminate pyruvate lyase )</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine , N-acetylmannosamine and N-acetylneuraminic acid dissimilation</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.3</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYLNEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__152__45__RXN" name="Inositol-hexakisphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ihpk3 ) or ( Ihpk1 ) or ( Ihpk2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol hexaphosphate kinase 3 ) or ( inositol hexaphosphate kinase 1 ) or ( inositol hexaphosphate kinase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__DIPHOSPHO__45__1D__45__MYO__45__INOSITOL__45__12346P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__151__45__RXN" name="Inositol-polyphosphate multikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ipmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate multikinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.151</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__17__45__RXN" name="3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pde2a ) or ( Pde6b ) or ( Pde4d ) or ( Pde6d ) or ( Pde8b ) or ( Pde3a ) or ( Pde3b ) or ( Pde6h ) or ( Pde10a ) or ( Pde6g ) or ( Pde8a ) or ( Pde4a ) or ( Pde11a ) or ( Pde1b ) or ( Pde1a ) or ( Pde7a ) or ( Pde7b ) or ( Pde4c ) or ( Pde1c )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphodiesterase 2A, cGMP-stimulated ) or ( phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide ) or ( phosphodiesterase 4D, cAMP specific ) or ( phosphodiesterase 6D, cGMP-specific, rod, delta ) or ( phosphodiesterase 8B ) or ( phosphodiesterase 3A, cGMP inhibited ) or ( phosphodiesterase 3B, cGMP-inhibited ) or ( phosphodiesterase 6H, cGMP-specific, cone, gamma ) or ( phosphodiesterase 10A ) or ( phosphodiesterase 6G, cGMP-specific, rod, gamma ) or ( phosphodiesterase 8A ) or ( phosphodiesterase 4A, cAMP specific ) or ( phosphodiesterase 11A ) or ( phosphodiesterase 1B, Ca2+-calmodulin dependent ) or ( phosphodiesterase 1A, calmodulin-dependent ) or ( phosphodiesterase 7A ) or ( phosphodiesterase 7B ) or ( phosphodiesterase 4C, cAMP specific ) or ( phosphodiesterase 1C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__3__45__5__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__99__46__28__45__RXN" name="Glucose--fructose oxidoreductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gfod2 ) or ( Gfod1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-fructose oxidoreductase domain containing 2 ) or ( glucose-fructose oxidoreductase domain containing 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.28</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__124__45__RXN" name="N-acetyllactosamine 3-&amp;alpha;-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ggta1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycoprotein galactosyltransferase alpha 1, 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.87</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__GALACTOSYL__45__13__45__BETA__45__D__45__GALACTOS" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__OXOPROLINASE__45__ATP__45__HYDROLYSING__45__RXN" name="5-oxoprolinase (ATP-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Oplah )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-oxoprolinase (ATP-hydrolysing) )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__OXOPROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARTRANSFORM__45__RXN" name="Phosphoribosylaminoimidazolecarboxamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Atic )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.3</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AICAR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLACYLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hadha ) or ( Echs1 ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit ) or ( enoyl Coenzyme A hydratase, short chain, 1, mitochondrial ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__57__45__RXN" name="Inositol-1,4-bisphosphate 1-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Inpp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate-1-phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.57</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__MYO__45__INOSITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Bckdhb ) or ( Tktl2 ) or ( Tktl1 ) or ( Tkt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched chain ketoacid dehydrogenase E1, beta polypeptide ) or ( transketolase-like 2 ) or ( transketolase-like 1 ) or ( transketolase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: non-oxidative branch of the pentose phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROID__45__21__45__MONOOXYGENASE__45__RXN" name="Steroid 21-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp21a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 21, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__21__45__Hydroxysteroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1685" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hk3 ) or ( Hkdc1 ) or ( Hk1 ) or ( Hk2 ) or ( Ltk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase 3 ) or ( hexokinase domain containing 1 ) or ( hexokinase 1 ) or ( hexokinase 2 ) or ( leukocyte tyrosine kinase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__35846" name="Carbonyl reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1c6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1, member C6 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of prostaglandins</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.184</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROSTAGLANDIN__45__H2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3DJ__45__35815" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BAIAEUBSP__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1c14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1, member C14 )</html:p>
<html:p>SUBSYSTEM: cholate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXO__45__CHOLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5822" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acp5 ) or ( Acp2 ) or ( Acpp ) or ( Acp1 ) or ( Acp6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acid phosphatase 5, tartrate resistant ) or ( acid phosphatase 2, lysosomal ) or ( acid phosphatase, prostate ) or ( acid phosphatase 1, soluble ) or ( acid phosphatase 6, lysophosphatidic )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__143__45__RXN" name="&amp;alpha;-1,6-mannosyl-glycoprotein &amp;beta;-1,2-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mgat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannoside acetylglucosaminyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.143</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSYL__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__GLUCOSAMINYL__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pdxk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal (pyridoxine, vitamin B6) kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHYLARGININASE__45__RXN" name="Dimethylargininase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ddah1 ) or ( Ddah2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dimethylarginine dimethylaminohydrolase 1 ) or ( dimethylarginine dimethylaminohydrolase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__596" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYLAMINE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIGLUCOACETYL__45__DOCOSANOATE__45__HYDROLYSIS__45__RXN" name="acetic-ester acetylhydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Esa4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( esterase A4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIGLUCOACETYL__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="DIGLUCO__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gale )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactose-4-epimerase, UDP )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-glucose conversion</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__30__45__RXN" name="Fucose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fpgt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fucose-1-phosphate guanylyltransferase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis II (from L-fucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.30</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__488" stoichiometry="1"/>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREONINE__45__RACEMASE__45__RXN" name="Threonine racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Srr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine racemase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__THREONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__12__46__2__45__RXN" name="Mitogen-activated protein kinase kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Map2k4 ) or ( Map2k1 ) or ( Map2k2 ) or ( Map2k6 ) or ( Map2k7 ) or ( Map2k3 ) or ( Pbk ) or ( Map2k5 ) or ( Map2k1ip1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mitogen-activated protein kinase kinase 4 ) or ( mitogen-activated protein kinase kinase 1 ) or ( mitogen-activated protein kinase kinase 2 ) or ( mitogen-activated protein kinase kinase 6 ) or ( mitogen-activated protein kinase kinase 7 ) or ( mitogen-activated protein kinase kinase 3 ) or ( PDZ binding kinase ) or ( mitogen-activated protein kinase kinase 5 ) or ( mitogen-activated protein kinase kinase 1 interacting protein 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.12.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__158__45__RXN" name="Inositol-pentakisphosphate 2-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ippk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol 1,3,4,5,6-pentakisphosphate 2-kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.158</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONOLACT__45__RXN" name="6-phosphogluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgls ) or ( H6pd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase ) or ( hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R81__45__RXN" name="Hexokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hk3 ) or ( Hkdc1 ) or ( Hk1 ) or ( Hk2 ) or ( Ltk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase 3 ) or ( hexokinase domain containing 1 ) or ( hexokinase 1 ) or ( hexokinase 2 ) or ( leukocyte tyrosine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__175__45__RXN" name="Glucuronyl-N-acetylgalactosaminylproteoglycan &amp;beta;-1,4-N- acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Chsy3 ) or ( Chsy1 ) or ( Chpf )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chondroitin sulfate synthase 3 ) or ( carbohydrate (chondroitin) synthase 1 ) or ( chondroitin polymerizing factor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.175</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCURONYL__45__ETCETERA__45__GALACTOSAMINYLPROTEO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__ETCETERA__45__GALACTOSAMINYLPROTEOGLYC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHONDROITIN__45__GLUCURONATE__45__5__45__EPIMERASE__45__RXN" name="Chondroitin-glucuronate 5-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dse )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dermatan sulfate epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHONDROITIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DERMATAN__45__L__45__IDURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GULONOLACTONE__45__OXIDASE__45__RXN" name="L-gulonolactone oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gulo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gulonolactone (L-) oxidase )</html:p>
<html:p>SUBSYSTEM: Vitamin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.8</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__329" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCISOM__45__RXN" name="Glucose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpi1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose phosphate isomerase 1 )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__70__45__RXN" name="&amp;delta;(14)-sterol reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tm7sf2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transmembrane 7 superfamily member 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__144__45__RXN" name="&amp;beta;-1,4-mannosyl-glycoprotein &amp;beta;-1,4-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mgat3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannoside acetylglucosaminyltransferase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.144</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRI__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8748" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Akp3 ) or ( Akp5 ) or ( Akp1 ) or ( Alpl ) or ( Alpi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alkaline phosphatase 3, intestine, not Mn requiring ) or ( alkaline phosphatase 5 ) or ( alkaline phosphatase 1 ) or ( alkaline phosphatase, liver/bone/kidney ) or ( alkaline phosphatase, intestinal )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8978" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTKIN__45__RXN" name="Glutamate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh18a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 18 family, member A1 )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYKI__45__RXN" name="Thymidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tk2 ) or ( Tk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine kinase 2, mitochondrial ) or ( thymidine kinase 1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITSYN__45__RXN" name="Citrate (si)-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cs ) or ( Csl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( citrate synthase ) or ( citrate synthase like )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8743" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pon1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( paraoxonase 1 )</html:p>
<html:p>SUBSYSTEM: methyl parathion degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8973" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8974" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__241" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylethanolamine-N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.28</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NOREPINEPHRINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__EPINEPHRINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8746" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pon1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( paraoxonase 1 )</html:p>
<html:p>SUBSYSTEM: paraoxon degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARAOXON" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
      <speciesReference species="DIETHYLPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8747" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Enpp3 ) or ( Enpp1 ) or ( Pde4dip ) or ( Enpp2 ) or ( Pde1b ) or ( Pde1a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleotide pyrophosphatase/phosphodiesterase 3 ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 1 ) or ( phosphodiesterase 4D interacting protein (myomegalin) ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 2 ) or ( phosphodiesterase 1B, Ca2+-calmodulin dependent ) or ( phosphodiesterase 1A, calmodulin-dependent )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIETHYLPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__8978" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__178__45__RXN" name="3-hydroxy-2-methylbutyryl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxysteroid (17-beta) dehydrogenase 10 )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation</html:p>
<html:p>SUBSYSTEM: 2-methylbutyrate biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.178</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__ACETO__45__ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16BDEPHOS__45__RXN" name="Fructose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fbp1 ) or ( Fbp3 ) or ( Fbp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose bisphosphatase 1 ) or ( fructose bisphosphatase 3 ) or ( fructose bisphosphatase 2 )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__NUCLEOTIDYLEXOTRANSFERASE__45__RXN" name="DNA nucleotidylexotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dntt ) or ( Polm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxynucleotidyltransferase, terminal ) or ( polymerase (DNA directed), mu )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.31</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__40__DEOXYNUCLEOTIDE__41____40__M__41__" stoichiometry="1"/>
      <speciesReference species="__124__Deoxy__45__Ribonucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__40__DEOXYNUCLEOTIDE__41____40__M__43__N__41__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__20__45__RXN" name="Methylenetetrahydrofolate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mthfr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5,10-methylenetetrahydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.20</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDE__45__GLUCOSYLTRANSFERASE__45__RXN" name="Ceramide glucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugcg )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose ceramide glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.80</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSYL_CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPMANDEHYDRA__45__RXN" name="GDP-mannose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gmds )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-mannose 4, 6-dehydratase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-&amp;alpha;-D-perosamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.47</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__149__45__RXN" name="1-phosphatidylinositol-5-phosphate 4-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pip4k2b ) or ( Pip4k2a ) or ( Pip4k2c )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol-5-phosphate 4-kinase, type II, beta ) or ( phosphatidylinositol-5-phosphate 4-kinase, type II, alpha ) or ( phosphatidylinositol-5-phosphate 4-kinase, type II, gamma )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.149</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__1D__45__MYO__45__INOSITOL__45__5__45__PHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__3__45__MONOOXYGENASE__45__RXN" name="Tyrosine 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Th )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine hydroxylase )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.2</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__5881</html:p>
<html:p>SIDE: TETRA__45__H__45__BIOPTERIN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYLCYC__45__RXN" name="Guanylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gucy1a2 ) or ( Gucy1a3 ) or ( Gucy2d ) or ( Npr2 ) or ( Gucy2e ) or ( Gucy1b3 ) or ( Gucy1b2 ) or ( Gucy2c ) or ( Gucy2f ) or ( Gucy2g ) or ( Npr1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanylate cyclase 1, soluble, alpha 2 ) or ( guanylate cyclase 1, soluble, alpha 3 ) or ( guanylate cyclase 2d ) or ( natriuretic peptide receptor 2 ) or ( guanylate cyclase 2e ) or ( guanylate cyclase 1, soluble, beta 3 ) or ( guanylate cyclase 1, soluble, beta 2 ) or ( guanylate cyclase 2c ) or ( guanylate cyclase 2f ) or ( guanylate cyclase 2g ) or ( natriuretic peptide receptor 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CGMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTEPADENYLYLTRAN__45__RXN" name="Pantetheine-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Coasy )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Coenzyme A synthase )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.3</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8730" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pib5pa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8732" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Adprh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-ribosylarginine hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="Omega__45__N__45____40__ADP__45__D__45__ribosyl__41____45__L__45__arginine" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="ADENOSINE_DIPHOSPHATE_RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARACHIDONATE__45__5__45__LIPOXYGENASE__45__RXN" name="Arachidonate 5-lipoxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Alox5 ) or ( Alox5ap )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 5-lipoxygenase ) or ( arachidonate 5-lipoxygenase activating protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.34</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6E8Z11Z14Z__45__5S__45__5__45__HYDROPEROXYCOSA__45__6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8772" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1b8 ) or ( Aldr3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1, member B8 ) or ( aldehyde reductase 3 )</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARABITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRIC__45__OXIDE__45__SYNTHASE__45__RXN" name="Nitric-oxide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nosip ) or ( Nos1ap ) or ( Nos2 ) or ( Nos1 ) or ( Nos3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitric oxide synthase interacting protein ) or ( nitric oxide synthase 1 (neuronal) adaptor protein ) or ( nitric oxide synthase 2, inducible, macrophage ) or ( nitric oxide synthase 1, neuronal ) or ( nitric oxide synthase 3, endothelial cell )</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.39</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NITRIC__45__OXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRIC__45__OXIDE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__AMINOADIPATE__45__AMINOTRANSFERASE__45__RXN" name="2-aminoadipate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aadat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminoadipate aminotransferase )</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.39</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__4__45__RXN" name="Formiminotetrahydrofolate cyclodeaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ftcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formiminotransferase cyclodeaminase )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__671" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIPHOSPHOMEVALONTE__45__DECARBOXYLASE__45__RXN" name="Diphosphomevalonate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mvd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mevalonate (diphospho) decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__98__46__2__45__RXN" name="Sulfiredoxin" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Srxn1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfiredoxin 1 homolog (S. cerevisiae) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.98.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7250" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7251" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__KINASE__45__RXN" name="Choline kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Chka ) or ( Chkb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline kinase alpha ) or ( choline kinase beta )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.32</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIP__45__KIN__45__RXN" name="Nucleoside-diphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nme3 ) or ( Nme1 ) or ( Nme4 ) or ( Nme2 ) or ( Rp2h ) or ( Nme5 ) or ( Nme7 ) or ( Nme6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( non-metastatic cells 3, protein expressed in ) or ( non-metastatic cells 1, protein (NM23A) expressed in ) or ( non-metastatic cells 4, protein expressed in ) or ( non-metastatic cells 2, protein (NM23B) expressed in ) or ( retinitis pigmentosa 2 homolog (human) ) or ( non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) ) or ( non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) ) or ( non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__45__PHOSPHATIDYLINOSITOL__45__3__45__KINASE__45__RXN" name="1-phosphatidylinositol 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pik3r3 ) or ( Pik3r2 ) or ( Pik3cd ) or ( Pik3c2a ) or ( Pik3r4 ) or ( Pik3r1 ) or ( Pik3c3 ) or ( Pik3c2g )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55) ) or ( phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) ) or ( phosphatidylinositol 3-kinase catalytic delta polypeptide ) or ( phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide ) or ( phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150 ) or ( phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) ) or ( phosphoinositide-3-kinase, class 3 ) or ( phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.137</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7226" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdps ) or ( Ggps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl diphosphate synthetase ) or ( geranylgeranyl diphosphate synthase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6645" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__4__46__1__46__14__45__RXN" name="1-aminocyclopropane-1-carboxylate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__68" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIOSEPISOMERIZATION__45__RXN" name="Triosephosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tpi1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triosephosphate isomerase 1 )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__99__45__RXN" name="24-hydroxycholesterol 7-alpha-hydroxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp39a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 39, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.99</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7240" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8351" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mocos )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( molybdenum cofactor sulfurase )</html:p>
<html:p>SUBSYSTEM: molybdenum cofactor biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="CPD__45__8123" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8124" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__AMINOLEVULINIC__45__ACID__45__SYNTHASE__45__RXN" name="5-aminolevulinic acid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Alas2 ) or ( Alas1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminolevulinic acid synthase 2, erythroid ) or ( aminolevulinic acid synthase 1 )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.37</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__78__45__RXN" name="Heparan-&amp;alpha;-glucosaminide N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hgsnat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heparan-alpha-glucosaminide N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.78</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7177" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7178" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLOSE__45__1__45__DEHYDROGENASE__45__RXN" name="D-xylose 1-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Xld1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylose dehydrogenase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.175</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__360" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5226" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mgea5 ) or ( Hexb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( meningioma expressed antigen 5 (hyaluronidase) ) or ( hexosaminidase B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.52</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__882" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAMMA__45__GLUTAMYLCYCLOTRANSFERASE__45__RXN" name="&amp;gamma;-glutamylcyclotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gctg )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamylcyclotransferase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.4</html:p>
<html:p>SIDE: L__45__2__45__AMINO__45__ACID</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__2__45__AMINO__45__ACID" stoichiometry="1"/>
      <speciesReference species="_5__45__OXOPROLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__221" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ddc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dopa decarboxylase )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__45__45__RXN" name="N-acetylglucosamine-1-phosphodiester &amp;alpha;-N-acetylglucosaminidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nagpa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOPROTEIN__45__ETCETERA__45__GLUCOSAMINYL__45__PHOSP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOPROTEIN__45__PHOSPHO__45__D__45__MANNOSE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TIGLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hadha ) or ( Echs1 ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit ) or ( enoyl Coenzyme A hydratase, short chain, 1, mitochondrial ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation</html:p>
<html:p>SUBSYSTEM: 2-methylbutyrate biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPAMIDOTRANS__45__RXN" name="Amidophosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ppat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosyl pyrophosphate amidotransferase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.14</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDP_TO_CTP_COF_RXN" name="CDP_TO_CTP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYGUANOSINE__45__KINASE__45__RXN" name="Deoxyguanosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dguok )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyguanosine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.113</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYGUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__12__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pts )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-pyruvoyl-tetrahydropterin synthase )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.12</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__138__45__RXN" name="Methylarsonite methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( As3mt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arsenic (+3 oxidation state) methyltransferase )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.137</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLARSONITE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYLARSINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIPHTHINE__45__SYNTHASE__45__RXN" name="Diphthine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dph5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DPH5 homolog (S. cerevisiae) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.98</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__CARBOXY__45__3__45__AMINOPROPYL__45__L__45__HISTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__CARBOXY__45__3__45__METHYLAMMONIOPROPYL__45__L__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5211" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pskh1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein serine kinase H1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="unphosphorylated__32__substrate" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="phosphorylated__32__substrate" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Abp1 ) or ( Aoc2 ) or ( Aoc3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amiloride binding protein 1 (amine oxidase, copper-containing) ) or ( amine oxidase, copper containing 2 (retina-specific) ) or ( amine oxidase, copper containing 3 )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8751" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Xdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8752" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Xdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__OXIDASE__45__RXN" name="Sulfite oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Suox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfite oxidase )</html:p>
<html:p>SUBSYSTEM: sulfite oxidation IV</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.8.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh2 ) or ( Aldh9a1 ) or ( Aldh3a2 ) or ( Aldh7a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 2, mitochondrial ) or ( aldehyde dehydrogenase 9, subfamily A1 ) or ( aldehyde dehydrogenase family 3, subfamily A2 ) or ( aldehyde dehydrogenase family 7, member A1 )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__3848" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp21a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 21, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of corticosteroids</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.10</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROGESTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_11__45__DEOXYCORTICOSTERONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8753" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Xdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9017" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Echs1 ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl Coenzyme A hydratase, short chain, 1, mitochondrial ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8754" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Xdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9017" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QOR__45__RXN" name="NADPH:quinone reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cryz )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( crystallin, zeta )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Semiquinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_GLT_COF_RXN" name="2-KETOGLUTARATE_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__77__45__RXN" name="Acyloxyacyl hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aoah )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyloxyacyl hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.77</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__ACYLOXYACYL__45__GROUP__45__OF__45__BACTERIAL__45__TOXIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="_3__45__HYDROXYACYL__45__GROUP__45__OF__45__BACTERIAL__45__TOXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEPHOSPHORYLATION__45__RXN" name="5&apos;-nucleotidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nt5c3l ) or ( Nt5e ) or ( Nt5c2 ) or ( Nt5c ) or ( Nt5dc3 ) or ( Entpd3 ) or ( Nt5c3 ) or ( Nt5dc1 ) or ( Nt5c1a ) or ( Nt5c1b ) or ( Nt5m ) or ( Nt5dc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase, cytosolic III-like ) or ( 5&apos; nucleotidase, ecto ) or ( 5&apos;-nucleotidase, cytosolic II ) or ( 5&apos;,3&apos;-nucleotidase, cytosolic ) or ( 5&apos;-nucleotidase domain containing 3 ) or ( ectonucleoside triphosphate diphosphohydrolase 3 ) or ( 5&apos;-nucleotidase, cytosolic III ) or ( 5&apos;-nucleotidase domain containing 1 ) or ( 5&apos;-nucleotidase, cytosolic IA ) or ( 5&apos;-nucleotidase, cytosolic IB ) or ( 5&apos;,3&apos;-nucleotidase, mitochondrial ) or ( 5&apos;-nucleotidase domain containing 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__145" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tm7sf2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transmembrane 7 superfamily member 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Otc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine transcarbamylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Maoa ) or ( Maob )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monoamine oxidase A ) or ( amine oxidase activity )</html:p>
<html:p>SUBSYSTEM: putrescine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__30" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__21__46__6__45__RXN" name="Lathosterol oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc5d )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.6</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__NH3__45__RXN" name="NAD(+) synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nadsyn1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD synthetase 1 )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOPAMINE__45__BETA__45__MONOOXYGENASE__45__RXN" name="Dopamine-&amp;beta;-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Moxd2 ) or ( Moxd1 ) or ( Dbh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monooxygenase, DBH-like 2 ) or ( monooxygenase, DBH-like 1 ) or ( dopamine beta hydroxylase )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.17.1</html:p>
<html:p>SIDE: L__45__DEHYDRO__45__ASCORBATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ASCORBATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NOREPINEPHRINE" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__0" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Satl1 ) or ( Sat2 ) or ( Sat1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine/spermine N1-acetyl transferase-like 1 ) or ( spermidine/spermine N1-acetyl transferase 2 ) or ( spermidine/spermine N1-acetyl transferase 1 )</html:p>
<html:p>SUBSYSTEM: putrescine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2141" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mgam )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maltase-glucoamylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__281" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdft1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl diphosphate farnesyl transferase 1 )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sqle )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene epoxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHAGALACTOSID__45__RXN" name="&amp;alpha;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gla )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactosidase, alpha )</html:p>
<html:p>SUBSYSTEM: melibiose degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MELIBIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADH__45__DEHYDROG__45__A__45__RXN" name="NADH dehydrogenase (ubiquinone)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ndufaf2 ) or ( Ndufa3 ) or ( Ndufs6 ) or ( Ndufa5 ) or ( Ndufb7 ) or ( Ndufa6 ) or ( mt-Nd6 ) or ( mt-Nd3 ) or ( Ndufv1 ) or ( Ndufb10 ) or ( Ndufa2 ) or ( Ndufb6 ) or ( mt-Nd4 ) or ( Ndufa8 ) or ( Ndufb4 ) or ( Ndufb9 ) or ( Ndufa7 ) or ( Ndufv2 ) or ( Ndufa9 ) or ( Ndufs7 ) or ( Ndufb11 ) or ( Ndufa10 ) or ( Ndufc1 ) or ( mt-Nd5 ) or ( Ndufa11 ) or ( Ndufaf1 ) or ( Ndufb3 ) or ( Ndufa4l2 ) or ( Ndufs3 ) or ( Ndufb5 ) or ( mt-Nd2 ) or ( Ndufb8 ) or ( Ndufs8 ) or ( Ndufa1 ) or ( 1700029P11Rik ) or ( Ndufs1 ) or ( Ndufs2 ) or ( Ndufa4 ) or ( Ndufc2 ) or ( 1500032D16Rik ) or ( Ndufb2 ) or ( Ndufa13 ) or ( Ndufa12 ) or ( Ndufs4 ) or ( mt-Nd4l ) or ( Ndufab1 ) or ( mt-Nd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 ) or ( NADH dehydrogenase (ubiquinone) Fe-S protein 6 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 ) or ( NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (B14) ) or ( NADH dehydrogenase 6, mitochondrial ) or ( NADH dehydrogenase 3, mitochondrial ) or ( NADH dehydrogenase (ubiquinone) flavoprotein 1 ) or ( NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2 ) or ( NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 ) or ( NADH dehydrogenase 4, mitochondrial ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8 ) or ( NADH dehydrogenase (ubiquinone) 1 beta subcomplex 4 ) or ( NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a) ) or ( NADH dehydrogenase (ubiquinone) flavoprotein 2 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9 ) or ( NADH dehydrogenase (ubiquinone) Fe-S protein 7 ) or ( NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10 ) or ( NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1 ) or ( NADH dehydrogenase 5, mitochondrial ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 11 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1 ) or ( NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 ) or ( NADH dehydrogenase (ubiquinone) Fe-S protein 3 ) or ( NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5 ) or ( NADH dehydrogenase 2, mitochondrial ) or ( NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 ) or ( NADH dehydrogenase (ubiquinone) Fe-S protein 8 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 ) or ( RIKEN cDNA 1700029P11 gene ) or ( NADH dehydrogenase (ubiquinone) Fe-S protein 1 ) or ( NADH dehydrogenase (ubiquinone) Fe-S protein 2 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4 ) or ( NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2 ) or ( RIKEN cDNA 1500032D16 gene ) or ( NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 ) or ( NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 ) or ( NADH dehydrogenase (ubiquinone) Fe-S protein 4 ) or ( NADH dehydrogenase 4L, mitochondrial ) or ( NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 ) or ( NADH dehydrogenase 1, mitochondrial )</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donors reaction list</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donor II</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donor III</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LEUKOTRIENE__45__B4__45__20__45__MONOOXYGENASE__45__RXN" name="Leukotriene-B4 20-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp4f39 ) or ( Cyp4f18 ) or ( Cyp4f14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 4, subfamily f, polypeptide 39 ) or ( cytochrome P450, family 4, subfamily f, polypeptide 18 ) or ( cytochrome P450, family 4, subfamily f, polypeptide 14 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.30</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6Z8E10E14Z__45__5S12R__45__512__45__DIHYDROXYI" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_20__45__OH__45__LTB4" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_325__45__BISPHOSPHATE__45__NUCLEOTIDASE__45__RXN" name="3&apos;(2&apos;),5&apos;-bisphosphate nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Bpnt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bisphosphate 3&apos;-nucleotidase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 4933439C20Rik ) or ( Pisd ) or ( D030013I16Rik )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RIKEN cDNA 4933439C20 gene ) or ( phosphatidylserine decarboxylase ) or ( RIKEN cDNA D030013I16 gene )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.65</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CEREBROSIDE__45__SULFATASE__45__RXN" name="Cerebroside-sulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Arsa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylsulfatase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSYLCERAMIDE__45__SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__45__GALACTOSYLCERAMIDE" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__67__45__RXN" name="Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pten )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatase and tensin homolog )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.67</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__INOSITOL__45__345__45__TRISPHOSPHAT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINYL__45__PYRUVATE__45__SPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGOMYELIN__45__PHOSPHODIESTERASE__45__RXN" name="Sphingomyelin phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Smpd4 ) or ( Enpp7 ) or ( Smpd2 ) or ( Smpd3 ) or ( Smpd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingomyelin phosphodiesterase 4 ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 7 ) or ( sphingomyelin phosphodiesterase 2, neutral ) or ( sphingomyelin phosphodiesterase 3, neutral ) or ( sphingomyelin phosphodiesterase 1, acid lysosomal )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPHINGO__45__MYELIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__13__45__RXN" name="Protein kinase C" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pkn1 ) or ( Prkcz ) or ( Prkca ) or ( Aurka ) or ( Prkce ) or ( Pkn2 ) or ( Prkcq ) or ( Prkci ) or ( Prkd3 ) or ( Prkcd ) or ( Prkd1 ) or ( Pkn3 ) or ( Prkch )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein kinase N1 ) or ( protein kinase C, zeta ) or ( protein kinase C, alpha ) or ( aurora kinase A ) or ( protein kinase C, epsilon ) or ( protein kinase N2 ) or ( protein kinase C, theta ) or ( protein kinase C, iota ) or ( protein kinase D3 ) or ( protein kinase C, delta ) or ( protein kinase D1 ) or ( protein kinase N3 ) or ( protein kinase C, eta )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__OXIDASE__45__RXN" name="Catechol oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Tyr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__385" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARDIOLIPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Crls1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cardiolipin synthase 1 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARDIOLIPIN" stoichiometry="1"/>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GULONATE__45__3__45__DEHYDROGENASE__45__RXN" name="L-gulonate 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cryl1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( crystallin, lambda 1 )</html:p>
<html:p>SUBSYSTEM: glucuronate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.45</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETO__45__L__45__GULONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2301" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ivd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isovaleryl coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__21__45__RXN" name="Polo kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Plk4 ) or ( Plk2 ) or ( Aurka ) or ( Plk3 ) or ( 6330514A18Rik )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polo-like kinase 4 (Drosophila) ) or ( polo-like kinase 2 (Drosophila) ) or ( aurora kinase A ) or ( polo-like kinase 3 (Drosophila) ) or ( RIKEN cDNA 6330514A18 gene )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATEPRIBOSYLTRANS__45__RXN" name="Nicotinate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Naprt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate phosphoribosyltransferase domain containing 1 )</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPICRED__45__RXN" name="Dihydrodipicolinate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 0610012D14Rik )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RIKEN cDNA 0610012D14 gene )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.26</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Nme3 ) or ( Nme1 ) or ( Nme4 ) or ( Nme2 ) or ( Rp2h ) or ( Nme5 ) or ( Nme7 ) or ( Nme6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( non-metastatic cells 3, protein expressed in ) or ( non-metastatic cells 1, protein (NM23A) expressed in ) or ( non-metastatic cells 4, protein expressed in ) or ( non-metastatic cells 2, protein (NM23B) expressed in ) or ( retinitis pigmentosa 2 homolog (human) ) or ( non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase) ) or ( non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) ) or ( non-metastatic cells 6, protein expressed in (nucleoside-diphosphate kinase) )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYRIBOSE__45__P__45__ALD__45__RXN" name="Deoxyribose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dera )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-deoxyribose-5-phosphate aldolase homolog (C. elegans) )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__141__45__RXN" name="4-&amp;alpha;-D-{(1->4)-&amp;alpha;-D-glucano}-trehalose trehalohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Amy1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amylase 1, salivary )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.141</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOOLIGOSYLTREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__22__45__RXN" name="(S)-3-amino-2-methylpropionate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Abat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.22</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__466" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__26__45__RXN" name="N4-(&amp;beta;-N-acetylglucosaminyl)-L-asparaginase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aga )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartylglucosaminidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__ETCETERA__45__L__45__ASPARAGINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__BETA__45__GLUCOSAMINYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPIONYL__45__COA__45__CARBOXY__45__RXN" name="Propionyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pcca ) or ( Pccb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( propionyl-Coenzyme A carboxylase, alpha polypeptide ) or ( propionyl Coenzyme A carboxylase, beta polypeptide )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: isoleucine degradation</html:p>
<html:p>SUBSYSTEM: 2-oxobutanoate degradation I</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__DECARBOXYLASE__45__RXN" name="UDP-glucuronate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Uxs1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucuronate decarboxylase 1 )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-xylose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.35</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="Myo-inositol-1(or 4)-monophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Impad1 ) or ( Impa1 ) or ( Impa2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol monophosphatase domain containing 1 ) or ( inositol (myo)-1(or 4)-monophosphatase 1 ) or ( inositol (myo)-1(or 4)-monophosphatase 2 )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALANINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Alanine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Agxt ) or ( Agxt2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alanine-glyoxylate aminotransferase ) or ( alanine-glyoxylate aminotransferase 2 )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.44</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__23__45__RXN" name="All-trans-retinol 13,14-reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Retsat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( retinol saturase (all trans retinol 13,14 reductase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.23</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7247" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RETINOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8729" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sult2a1 ) or ( Sult2a2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 ) or ( sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.14</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="glycolithocholate" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="glycolithocholate__32__3__45__sulfate" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTMPKI__45__RXN" name="Thymidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dtymk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxythymidylate kinase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8728" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ipmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate multikinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.151</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__4__46__10__45__RXN" name="Biotin--[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hlcs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.10</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
      <speciesReference species="APO__45____91__PROPANOYL__45__COA__58__CARBON__45__DIOXIDE__32__LIGASE__32____40__ADP__45__FORMING__41____93__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__PROPANOYL__45__COA__58__CARBON__45__DIOXIDE__32__LIGASE__32____40__ADP__45__FORMING__41____93__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__ESTER__45__SULFOTRANSFERASE__45__RXN" name="Tyrosine-ester sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sult1a1 ) or ( Sult1d1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfotransferase family 1A, phenol-preferring, member 1 ) or ( sulfotransferase family 1D, member 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.9</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__TYROSINE__45__METHYL__45__ESTER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__TYROSINE__45__METHYL__45__ESTER__45__4__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__46__45__RXN" name="Fructose-2,6-bisphosphate 2-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pfkfb3 ) or ( Pfkfb2 ) or ( Pfkfb1 ) or ( Pfkfb4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__535" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROID__45__17__45__ALPHA__45__MONOOXYGENASE__45__RXN" name="Steroid 17-&amp;alpha;-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp17a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 17, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.9</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__17__45__Alpha__45__Hydroxysteroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTAGLY__45__RXN" name="Cystathionine &amp;gamma;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cth )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionase (cystathionine gamma-lyase) )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: homocysteine degradation</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE__45__1__45__EPIMERASE__45__RXN" name="Aldose 1-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Galm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactose mutarotase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__114__45__RXN" name="Hexaprenyldihydroxybenzoate methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Coq3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( coenzyme Q3 homolog, methyltransferase (yeast) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.114</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HEXAPRENYL__45__45__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HEXAPRENYL__45__4__45__HYDROXY__45__5__45__METHOXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTEINE__45__DIOXYGENASE__45__RXN" name="Cysteine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cdo1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine dioxygenase 1, cytosolic )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation VI</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.20</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__39__45__RXN" name="Alkylglycerophosphoethanolamine phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Enpp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleotide pyrophosphatase/phosphodiesterase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.39</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALKYL__45__SN__45__GLYCERO__45__PHOSPHOETHANOLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__Alkyl__45__sn__45__glycerol__45__3__45__phosphates__124__" stoichiometry="1"/>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__10__46__1__45__RXN" name="Receptor protein-tyrosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Epha3 ) or ( Flt1 ) or ( Ephb4 ) or ( Ddr2 ) or ( Insr ) or ( Pdgfrb ) or ( Ltk ) or ( Fgfr1 ) or ( Fgfr4 ) or ( Ddr1 ) or ( Csf1r ) or ( Ror1 ) or ( Ephb3 ) or ( Epha8 ) or ( Ntrk2 ) or ( Met ) or ( Epha1 ) or ( Ret ) or ( Mertk ) or ( Epha4 ) or ( Epha10 ) or ( Fgfr3 ) or ( Insrr ) or ( Epha6 ) or ( Ntrk1 ) or ( Musk ) or ( Erbb4 ) or ( Ntrk3 ) or ( Alk ) or ( Epha5 ) or ( Ephb2 ) or ( Kit ) or ( Tek ) or ( Flt4 ) or ( Epha2 ) or ( Epha7 ) or ( Flt3 ) or ( Tyro3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Eph receptor A3 ) or ( FMS-like tyrosine kinase 1 ) or ( Eph receptor B4 ) or ( discoidin domain receptor family, member 2 ) or ( insulin receptor ) or ( platelet derived growth factor receptor, beta polypeptide ) or ( leukocyte tyrosine kinase ) or ( fibroblast growth factor receptor 1 ) or ( fibroblast growth factor receptor 4 ) or ( discoidin domain receptor family, member 1 ) or ( colony stimulating factor 1 receptor ) or ( receptor tyrosine kinase-like orphan receptor 1 ) or ( Eph receptor B3 ) or ( Eph receptor A8 ) or ( neurotrophic tyrosine kinase, receptor, type 2 ) or ( met proto-oncogene ) or ( Eph receptor A1 ) or ( ret proto-oncogene ) or ( c-mer proto-oncogene tyrosine kinase ) or ( Eph receptor A4 ) or ( Eph receptor A10 ) or ( fibroblast growth factor receptor 3 ) or ( insulin receptor-related receptor ) or ( Eph receptor A6 ) or ( neurotrophic tyrosine kinase, receptor, type 1 ) or ( muscle, skeletal, receptor tyrosine kinase ) or ( v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) ) or ( neurotrophic tyrosine kinase, receptor, type 3 ) or ( anaplastic lymphoma kinase ) or ( Eph receptor A5 ) or ( Eph receptor B2 ) or ( kit oncogene ) or ( endothelial-specific receptor tyrosine kinase ) or ( FMS-like tyrosine kinase 4 ) or ( Eph receptor A2 ) or ( Eph receptor A7 ) or ( FMS-like tyrosine kinase 3 ) or ( TYRO3 protein tyrosine kinase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.10.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__3803" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd3b1 ) or ( Hsd3b3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of corticosteroids</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.145</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREGNENOLONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROGESTERONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GARTRANSFORMYL2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gart )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINLYA__45__RXN" name="Argininosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Asl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIS5__45__ADENOSYL__45__TRIPHOSPHATASE__45__RXN" name="Bis(5&apos;-adenosyl)-triphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fhit )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fragile histidine triad gene )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.29</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE5TRIPHOSPHO5ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3902" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gcdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl-Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RETINAL__45__DEHYDROGENASE__45__RXN" name="Retinal dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh8a1 ) or ( Aldh1a2 ) or ( Aldh1a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 8 family, member A1 ) or ( aldehyde dehydrogenase family 1, subfamily A2 ) or ( aldehyde dehydrogenase family 1, subfamily A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.36</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RETINAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RETINOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6841" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpd2 ) or ( Gpd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol phosphate dehydrogenase 2, mitochondrial ) or ( glycerol-3-phosphate dehydrogenase 1 (soluble) )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__709" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd3b6 ) or ( Hsd3b1 ) or ( Hsd3b2 ) or ( Hsd3b3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ) or ( hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__707" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__708" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NAD__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Me2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malic enzyme 2, NAD(+)-dependent, mitochondrial )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.38</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__707" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhcr7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__700" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__706" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Echs1 ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl Coenzyme A hydratase, short chain, 1, mitochondrial ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_7__45__DEHYDROCHOLESTEROL__45__REDUCTASE__45__RXN" name="7-dehydrocholesterol reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhcr7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCDEHYDROG__45__RXN" name="Phosphoglycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Phgdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-phosphoglycerate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.95</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__228__45__RXN" name="Lactosylceramide 4-&amp;alpha;-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( A4galt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha 1,4-galactosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.228</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTOLIPIN_H" stoichiometry="1"/>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="D__45__GALACTOSYL__45__14__45__D__45__GALACTOSYL__45__14__45__D__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTCYSLIG__45__RXN" name="Glutamate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gclm ) or ( Gclc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate-cysteine ligase , modifier subunit ) or ( glutamate-cysteine ligase, catalytic subunit )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hadha ) or ( Echs1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit ) or ( enoyl Coenzyme A hydratase, short chain, 1, mitochondrial )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="E__45__PHENYLITACONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYMETHYL__45__HYDROXYPHENYLPROPCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREOSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMPSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adsl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLESTERASE__45__RXN" name="acetic-ester acetylhydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Es3 ) or ( Saac ) or ( Esa4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( esterase 3 ) or ( sialic acid O-acetylation ) or ( esterase A4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acetic__45__Esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__LACTATE__45__DEHYDROGENASE__45__RXN" name="L-lactate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ldhc ) or ( Ldha ) or ( Ldhal6b ) or ( Ldhb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lactate dehydrogenase C ) or ( lactate dehydrogenase A ) or ( lactate dehydrogenase A-like 6B ) or ( lactate dehydrogenase B )</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to lactate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.27</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENIIISYN__45__RXN" name="uroporphyrinogen-III synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Uros )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen III synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.75</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__68__45__RXN" name="Glycoprotein 6-&amp;alpha;-L-fucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fut8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fucosyltransferase 8 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.68</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12" stoichiometry="1"/>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F6" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_10__45__FORMYL__45__THF_TO_THF_COF_RXN" name="10-FORMYL-THF_TO_THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSACETYLGLUCOSAMINEMUT__45__RXN" name="Phosphoacetylglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgm1 ) or ( Pgm3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglucomutase 1 ) or ( phosphoglucomutase 3 )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__A2__45__RXN" name="Phospholipase A2" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pla2g6 ) or ( Pla2g5 ) or ( Pla2g2a ) or ( Pla2g2c ) or ( Pla2g4f ) or ( Pla2g12b ) or ( Pla2g1b ) or ( Pla2g4a ) or ( Pla2g4d ) or ( Pla2g12a ) or ( Pla2g2f ) or ( Pla2g4e ) or ( Pla2g2e ) or ( Pla2g4b ) or ( Pla2g2d ) or ( Pla2g10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase A2, group VI ) or ( phospholipase A2, group V ) or ( phospholipase A2, group IIA (platelets, synovial fluid) ) or ( phospholipase A2, group IIC ) or ( phospholipase A2, group IVF ) or ( phospholipase A2, group XIIB ) or ( phospholipase A2, group IB, pancreas ) or ( phospholipase A2, group IVA (cytosolic, calcium-dependent) ) or ( phospholipase A2, group IVD ) or ( phospholipase A2, group XIIA ) or ( phospholipase A2, group IIF ) or ( phospholipase A2, group IVE ) or ( phospholipase A2, group IIE ) or ( phospholipase A2, group IVB (cytosolic) ) or ( phospholipase A2, group IID ) or ( phospholipase A2, group X )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.4</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATEREDUCT__45__RXN" name="Dihydrofolate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhfr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__11__45__RXN" name="Glycogen (starch) synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gys2 ) or ( Gys1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen synthase 2 ) or ( glycogen synthase 1, muscle )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.11</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7693" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adh1 ) or ( Adh4 ) or ( D3Nds9 ) or ( Adh7 ) or ( Adh6b ) or ( Adh5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase 1 (class I) ) or ( alcohol dehydrogenase 4 (class II), pi polypeptide ) or ( DNA segment, Chr 3, Nuffield Department of Surgery 9 ) or ( alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ) or ( alcohol dehydrogenase 6B (class V) ) or ( alcohol dehydrogenase 5 (class III), chi polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7031" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7032" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpam ) or ( A530057A03Rik )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate acyltransferase, mitochondrial ) or ( RIKEN cDNA A530057A03 gene )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.15</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__17__45__RXN" name="Calcium/calmodulin-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Camk2n1 ) or ( Camk1g ) or ( Camkk2 ) or ( Camk2g ) or ( Camk2a ) or ( Camk2d ) or ( Pnck ) or ( Camkk1 ) or ( Camk1 ) or ( Camk2b ) or ( Camk1d ) or ( Camk2n2 ) or ( Camk4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( calcium/calmodulin-dependent protein kinase II inhibitor 1 ) or ( calcium/calmodulin-dependent protein kinase I gamma ) or ( calcium/calmodulin-dependent protein kinase kinase 2, beta ) or ( calcium/calmodulin-dependent protein kinase II gamma ) or ( calcium/calmodulin-dependent protein kinase II alpha ) or ( calcium/calmodulin-dependent protein kinase II, delta ) or ( pregnancy upregulated non-ubiquitously expressed CaM kinase ) or ( calcium/calmodulin-dependent protein kinase kinase 1, alpha ) or ( calcium/calmodulin-dependent protein kinase I ) or ( calcium/calmodulin-dependent protein kinase II, beta ) or ( calcium/calmodulin-dependent protein kinase ID ) or ( calcium/calmodulin-dependent protein kinase II inhibitor 2 ) or ( calcium/calmodulin-dependent protein kinase IV )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7694" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adh1 ) or ( Adh4 ) or ( D3Nds9 ) or ( Adh7 ) or ( Adh6b ) or ( Adh5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase 1 (class I) ) or ( alcohol dehydrogenase 4 (class II), pi polypeptide ) or ( DNA segment, Chr 3, Nuffield Department of Surgery 9 ) or ( alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide ) or ( alcohol dehydrogenase 6B (class V) ) or ( alcohol dehydrogenase 5 (class III), chi polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLBUT__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7033" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROSTAGLANDIN__45__ENDOPEROXIDE__45__SYNTHASE__45__RXN" name="Prostaglandin-endoperoxide synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ptgs1 ) or ( Ptgs2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostaglandin-endoperoxide synthase 1 ) or ( prostaglandin-endoperoxide synthase 2 )</html:p>
<html:p>SUBSYSTEM: biosynthesis of prostaglandins</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3DJ__45__35588" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM__45__RXN" name="Cytidine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cda ) or ( Aicda ) or ( Apobec1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase ) or ( activation-induced cytidine deaminase ) or ( apolipoprotein B editing complex 1 )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCDEHYDRAT__45__RXN" name="dTDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tgds )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TDP-glucose 4,6-dehydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9024" name="Glucan 1,4-&amp;alpha;-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mgam )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maltase-glucoamylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9025" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pygl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( liver glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="adenylosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Adss ) or ( Adssl1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate synthetase, non muscle ) or ( adenylosuccinate synthetase like 1 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.4</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMACTRANS__45__RXN" name="Diamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Satl1 ) or ( Sat2 ) or ( Sat1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine/spermine N1-acetyl transferase-like 1 ) or ( spermidine/spermine N1-acetyl transferase 2 ) or ( spermidine/spermine N1-acetyl transferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aliphatic__45__N__45__Acetyl__45__Diamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOGLUCMUT__45__RXN" name="Phosphoglucomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgm2 ) or ( Pgm5 ) or ( Pgm1 ) or ( Pgm3 ) or ( Pgm2l1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglucomutase 2 ) or ( phosphoglucomutase 5 ) or ( phosphoglucomutase 1 ) or ( phosphoglucomutase 3 ) or ( phosphoglucomutase 2-like 1 )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-glucose conversion</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gpi1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose phosphate isomerase 1 )</html:p>
<html:p>SUBSYSTEM: sucrose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__37__45__RXN" name="2&apos;,3&apos;-cyclic nucleotide 3&apos;-phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cnp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2&apos;,3&apos;-cyclic nucleotide 3&apos; phosphodiesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.37</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__2__45__3__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEH__45__RXN" name="Malate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mdh2 ) or ( Mdh1 ) or ( Mdh1b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate dehydrogenase 2, NAD (mitochondrial) ) or ( malate dehydrogenase 1, NAD (soluble) ) or ( malate dehydrogenase 1B, NAD (soluble) )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.37</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__7" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Comt ) or ( Comtd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catechol-O-methyltransferase ) or ( catechol-O-methyltransferase domain containing 1 )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.6</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__5" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 2, mitochondrial )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__6" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Comt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catechol-O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.6</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7651" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sult1a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfotransferase family 1A, phenol-preferring, member 1 )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.1</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>SIDE: PAP</html:p>
<html:p>SIDE: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACYLNEURAMINATE__45__9__45__PHOSPHATASE__45__RXN" name="N-acylneuraminate-9-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Nanp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylneuraminic acid phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.29</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1119" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__3__46__5__45__RXN" name="Prenylcysteine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pcyox1 ) or ( Pcyox1l )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prenylcysteine oxidase 1 ) or ( prenylcysteine oxidase 1 like )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__PRENYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="PRENAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNPOXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnpo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine 5&apos;-phosphate oxidase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIOTINIDASE__45__RXN" name="Biotinidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Btd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotinidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__574" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__98__45__RXN" name="Cholesterol 24-hydroxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp46a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450, family 46, subfamily a, polypeptide 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.98</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7239" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__O__45__METHYLTRANSFERASE__45__RXN" name="Catechol O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Comt ) or ( Comtd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catechol-O-methyltransferase ) or ( catechol-O-methyltransferase domain containing 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.6</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__400" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOMEVALONATE__45__KINASE__45__RXN" name="Phosphomevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pmvk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomevalonate kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__TRIPHOSPHATASE__45__RXN" name="Nucleoside-triphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ruvbl2 ) or ( Clpx ) or ( Psmc2 ) or ( Ntp ) or ( Mmaa ) or ( Katnal1 ) or ( Atp5b ) or ( Psmc4 ) or ( Abcb1b ) or ( Katna1 ) or ( Abcb1a ) or ( Abca7 ) or ( Cdc6 ) or ( Abcb4 ) or ( Entpd3 ) or ( Clpb ) or ( Orc1l )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RuvB-like protein 2 ) or ( caseinolytic peptidase X (E.coli) ) or ( proteasome (prosome, macropain) 26S subunit, ATPase 2 ) or ( nucleotriphosphatase ) or ( methylmalonic aciduria (cobalamin deficiency) type A ) or ( katanin p60 subunit A-like 1 ) or ( ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit ) or ( proteasome (prosome, macropain) 26S subunit, ATPase, 4 ) or ( ATP-binding cassette, sub-family B (MDR/TAP), member 1B ) or ( katanin p60 (ATPase-containing) subunit A1 ) or ( ATP-binding cassette, sub-family B (MDR/TAP), member 1A ) or ( ATP-binding cassette, sub-family A (ABC1), member 7 ) or ( cell division cycle 6 homolog (S. cerevisiae) ) or ( ATP-binding cassette, sub-family B (MDR/TAP), member 4 ) or ( ectonucleoside triphosphate diphosphohydrolase 3 ) or ( ClpB caseinolytic peptidase B homolog (E. coli) ) or ( origin recognition complex, subunit 1-like (S.cereviaiae) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__149__45__RXN" name="20-&amp;alpha;-hydroxysteroid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1c18 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1, member C18 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.149</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_17__45__ALPHA20__45__ALPHA__45__DIHYDROXYPREGN__45__4__45__EN__45__3__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_17__45__ALPHA__45__HYDROXYPROGESTERONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__4" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Maoa ) or ( Maob )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monoamine oxidase A ) or ( amine oxidase activity )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTP_TO_CMP_COF_RXN" name="CTP_TO_CMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gmps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine monphosphate synthetase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.2</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Faah )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acid amide hydrolase )</html:p>
<html:p>SUBSYSTEM: anandamide degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7598" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FPPSYN__45__RXN" name="geranyltranstransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdps ) or ( Fntb ) or ( Ggps1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl diphosphate synthetase ) or ( farnesyltransferase, CAAX box, beta ) or ( geranylgeranyl diphosphate synthase 1 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NADP__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mod2 ) or ( Me1 ) or ( Me3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malic enzyme complex, mitochondrial ) or ( malic enzyme 1, NADP(+)-dependent, cytosolic ) or ( malic enzyme 3, NADP(+)-dependent, mitochondrial )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.40</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUERCETIN__45__23__45__DIOXYGENASE__45__RXN" name="Quercetin 2,3-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hpd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxyphenylpyruvic acid dioxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.24</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__520" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PROTOCATECHUOYLPHLOROGLUCINOLCARBOXYLA" stoichiometry="1"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYPHENYLPYRUVATE__45__DIOXYGENASE__45__RXN" name="4-hydroxyphenylpyruvate dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hpd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxyphenylpyruvic acid dioxygenase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.27</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__101__45__RXN" name="&amp;alpha;-1,3-mannosyl-glycoprotein &amp;beta;-1,2-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mgat1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannoside acetylglucosaminyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.101</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__MANNOSYL__45__13__45__R1__45__BETA__45__D__45__MANNOSY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12__45__ALPHA__45__D" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Glyctk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R9__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hadha ) or ( Echs1 ) or ( Ehhadh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit ) or ( enoyl Coenzyme A hydratase, short chain, 1, mitochondrial ) or ( enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CREATINE__45__KINASE__45__RXN" name="Creatine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ckb ) or ( Ckmt1 ) or ( Ckmt2 ) or ( Ckm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( creatine kinase, brain ) or ( creatine kinase, mitochondrial 1, ubiquitous ) or ( creatine kinase, mitochondrial 2 ) or ( creatine kinase, muscle )</html:p>
<html:p>SUBSYSTEM: creatine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.3.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CREATINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CREATINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fpgs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamyl synthetase )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Folatepolyglutamate__45__n1__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD_TO_NADH_COF_RXN" name="NAD_TO_NADH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHENYLTHFCYCLOHYDRO__45__RXN" name="Methenyltetrahydrofolate cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mthfd2 ) or ( Mthfd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase ) or ( methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYLESTERASE__45__RXN" name="Carboxylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Es31 ) or ( Es1 ) or ( Es9 ) or ( AU018778 ) or ( Ces2 ) or ( Es29 ) or ( Ces7 ) or ( Es22 ) or ( Es11 ) or ( Ces3 ) or ( Ces6 ) or ( Ces1 ) or ( Es2 ) or ( Ces5 ) or ( Es23 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( esterase 31 ) or ( esterase 1 ) or ( esterase 9 ) or ( expressed sequence AU018778 ) or ( carboxylesterase 2 ) or ( esterase 29 ) or ( carboxylesterase 7 ) or ( esterase 22 ) or ( esterase 11 ) or ( carboxylesterase 3 ) or ( carboxylesterase 6 ) or ( carboxylesterase 1 ) or ( esterase 2 ) or ( carboxylesterase 5 ) or ( esterase 23 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2PGADEHYDRAT__45__RXN" name="Phosphopyruvate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Eno1 ) or ( Eno3 ) or ( Eno2 ) or ( 6430537H07Rik )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enolase 1, alpha non-neuron ) or ( enolase 3, beta muscle ) or ( enolase 2, gamma neuronal ) or ( RIKEN cDNA 6430537H07 gene )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMKALT__45__RXN" name="T2-induced deoxynucleotide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Mpp5 ) or ( Guk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) ) or ( guanylate kinase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOKIN__45__RXN" name="Gluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tyk2 ) or ( 5133401N09Rik )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine kinase 2 ) or ( RIKEN cDNA 5133401N09 gene )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__149__45__RXN" name="N-acetyllactosaminide &amp;beta;-1,3-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B3gnt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.149</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__13__45__ETCETERA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__8__45__RXN" name="&amp;alpha;-N-acetyl-neuraminide &amp;alpha;-2,8-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( St8sia1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.8</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__23__45__ETCETERA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__28__45__ETCETERA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRYL__45__COA__45__HYDROLASE__45__RXN" name="3-hydroxyisobutyryl-CoA hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hibch )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyisobutyryl-Coenzyme A hydrolase )</html:p>
<html:p>SUBSYSTEM: valine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERSYN__45__RXN" name="CDP-diacylglycerol--serine O-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ptdss1 ) or ( Ptdss2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine synthase 1 ) or ( phosphatidylserine synthase 2 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.8</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIOPTERIN_TO_TETRA__45__H__45__BIOPTERIN_COF_RXN" name="BIOPTERIN_TO_TETRA-H-BIOPTERIN_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__6__46__1__46__10__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pts )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-pyruvoyl-tetrahydropterin synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__ETCETERA__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__ETCETERA__45__DIHYDROXYPTERIDINE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNDECARBOX__45__RXN" name="Ornithine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Oaz2 ) or ( D12Nds11 ) or ( Adc ) or ( Odc1 ) or ( Oaz1 ) or ( Oaz3 ) or ( Azin1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine decarboxylase antizyme 2 ) or ( DNA segment, Chr 12, Nuffield Department of Surgery 11 ) or ( arginine decarboxylase ) or ( ornithine decarboxylase, structural 1 ) or ( ornithine decarboxylase antizyme 1 ) or ( ornithine decarboxylase antizyme 3 ) or ( antizyme inhibitor 1 )</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.17</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__KIN__45__RXN" name="Glycerol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gyk ) or ( Gk2 ) or ( Gk5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol kinase ) or ( glycerol kinase 2 ) or ( glycerol kinase 5 (putative) )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.30</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URKI__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Uck2 ) or ( BC016495 ) or ( Uck1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine-cytidine kinase 2 ) or ( cDNA sequence BC016495 ) or ( uridine-cytidine kinase 1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDE__45__CHOLINEPHOSPHOTRANSFERASE__45__RXN" name="Ceramide cholinephosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Sgms2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingomyelin synthase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="SPHINGO__45__MYELIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSENOYLCOARED__45__RXN" name="Trans-2-enoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pecr ) or ( Mecr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal trans-2-enoyl-CoA reductase ) or ( mitochondrial trans-2-enoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__60__45__RXN" name="Protein geranylgeranyltransferase type II" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Rabggta ) or ( Rabggtb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Rab geranylgeranyl transferase, a subunit ) or ( RAB geranylgeranyl transferase, b subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.60</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__CYSTEINE" stoichiometry="1"/>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__GERANYLGERANYL__45__PROTEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__83__45__RXN" name="Dolichyl-phosphate &amp;beta;-D-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dpm1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dolichol-phosphate (beta-D) mannosyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.83</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PMPOXI__45__RXN" name="Pyridoxamine-phosphate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pnpo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine 5&apos;-phosphate oxidase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCORN__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Oat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N2__45__SUCCINYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__UREIDOPROPIONASE__45__RXN" name="&amp;beta;-ureidopropionase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pd ) or ( Upb1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrimidine degrading ) or ( ureidopropionase, beta )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPRODEHYDROG__45__RXN" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Prodh2 ) or ( Prodh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline dehydrogenase (oxidase) 2 ) or ( proline dehydrogenase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__4__45__HYDROXY__45__PROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__15__45__RXN" name="Cholinephosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pcyt1a ) or ( Pcyt1b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphate cytidylyltransferase 1, choline, alpha isoform ) or ( phosphate cytidylyltransferase 1, choline, beta isoform )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.15</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADP_TO_NADPH_COF_RXN" name="NADP_TO_NADPH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINE__45__6__45__P__45__DEAMIN__45__RXN" name="Glucosamine-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gnpda1 ) or ( Gnpda2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine-6-phosphate deaminase 1 ) or ( glucosamine-6-phosphate deaminase 2 )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__13__45__RXN" name="Mannose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gmppb ) or ( Gmppa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-mannose pyrophosphorylase B ) or ( GDP-mannose pyrophosphorylase A )</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.13</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UTPHEXPURIDYLYLTRANS__45__RXN" name="UTP--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugp2 ) or ( Galt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose pyrophosphorylase 2 ) or ( galactose-1-phosphate uridyl transferase )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARACHIDONATE__45__12__45__LIPOXYGENASE__45__RXN" name="Arachidonate 12-lipoxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Alox12 ) or ( Alox15 ) or ( Alox12e )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 12-lipoxygenase ) or ( arachidonate 15-lipoxygenase ) or ( arachidonate lipoxygenase, epidermal )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z8Z10E14Z__45__12S__45__12__45__HYDROPEROXYICOS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__153__45__RXN" name="Phosphatidylinositol-4,5-bisphosphate 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pik3ca ) or ( Pik3cd ) or ( Pik3cb ) or ( Pik3cg )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 3-kinase, catalytic, alpha polypeptide ) or ( phosphatidylinositol 3-kinase catalytic delta polypeptide ) or ( phosphatidylinositol 3-kinase, catalytic, beta polypeptide ) or ( phosphoinositide-3-kinase, catalytic, gamma polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.153</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYLINOSITOL__45__345__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYSYN__45__RXN" name="phosphatidate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cds2 ) or ( Cds1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 ) or ( CDP-diacylglycerol synthase 1 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.41</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOADEHYDROG__45__RXN" name="Acyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acadsb ) or ( Acad8 ) or ( Acadm ) or ( Acadvl ) or ( Acox2 ) or ( Acad11 ) or ( Iws1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-Coenzyme A dehydrogenase, short/branched chain ) or ( acyl-Coenzyme A dehydrogenase family, member 8 ) or ( acyl-Coenzyme A dehydrogenase, medium chain ) or ( acyl-Coenzyme A dehydrogenase, very long chain ) or ( acyl-Coenzyme A oxidase 2, branched chain ) or ( acyl-Coenzyme A dehydrogenase family, member 11 ) or ( IWS1 homolog (S. cerevisiae) )</html:p>
<html:p>SUBSYSTEM: fatty acid oxidation pathway I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBONYL__45__REDUCTASE__45__NADPH__45__RXN" name="Carbonyl reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Cbr1 ) or ( Cbr4 ) or ( Cbr3 ) or ( Cbr2 ) or ( Dhrs4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbonyl reductase 1 ) or ( carbonyl reductase 4 ) or ( carbonyl reductase 3 ) or ( carbonyl reductase 2 ) or ( dehydrogenase/reductase (SDR family) member 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.184</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__CHOH__45__R__38__amp__59__apos__59__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__CO__45__R__38__amp__59__apos__59__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERONE__45__KINASE__45__RXN" name="Glycerone kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dak )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxyacetone kinase 2 homolog (yeast) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.29</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADP_TO_ATP_COF_RXN" name="ADP_TO_ATP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__34__45__RXN" name="6,7-dihydropteridine reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Qdpr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinoid dihydropteridine reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.34</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5678__45__TETRAHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_67__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOPARATHION__45__PHOSPHATASE__45__RXN" name="Aryldialkylphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Pon1 ) or ( Pon2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( paraoxonase 1 ) or ( paraoxonase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__259" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCPDIESTER__45__RXN" name="Glycerophosphodiester phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Enpp6 ) or ( Gdpd5 ) or ( Gde1 ) or ( Gdpd3 ) or ( Gdpd4 ) or ( Gdpd1 ) or ( Gdpd2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleotide pyrophosphatase/phosphodiesterase 6 ) or ( glycerophosphodiester phosphodiesterase domain containing 5 ) or ( glycerophosphodiester phosphodiesterase 1 ) or ( glycerophosphodiester phosphodiesterase domain containing 3 ) or ( glycerophosphodiester phosphodiesterase domain containing 4 ) or ( glycerophosphodiester phosphodiesterase domain containing 1 ) or ( glycerophosphodiester phosphodiesterase domain containing 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.46</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycerophosphodiesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMHYDR__45__RXN" name="Fumarate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fh1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarate hydratase 1 )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETYL__45__COA__45__TRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Oxct1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxoacid CoA transferase 1 )</html:p>
<html:p>SUBSYSTEM: acetoacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AROMATIC__45__L__45__AMINO__45__ACID__45__DECARBOXYLASE__45__RXN" name="Aromatic-L-amino-acid decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ddc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dopa decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Sterol O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Soat1 ) or ( Soat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol O-acyltransferase 1 ) or ( sterol O-acyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.26</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLESTEROL_ESTER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__226__45__RXN" name="N-acetylgalactosaminyl-proteoglycan 3-&amp;beta;-glucuronosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Chsy3 ) or ( Chsy1 ) or ( Chpf )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chondroitin sulfate synthase 3 ) or ( carbohydrate (chondroitin) synthase 1 ) or ( chondroitin polymerizing factor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.226</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__acetyl__45__beta__45__D__45__galactosaminyl__45____40__1__45____62__4__41____45__beta__45__D__45__glucuronosyl__45__proteoglycan" stoichiometry="1"/>
      <speciesReference species="UDP__45__alpha__45__D__45__glucuronate" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="beta__45__D__45__glucuronosyl__45____40__1__45____62__3__41____45__N__45__acetyl__45__beta__45__D__45__galactosaminyl__45____40__1__45____62__4__41____45__beta__45__D__45__glucuronosyl__45__proteoglycan" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYMALTOPHOSPHORYL__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pygm ) or ( Pygl ) or ( Pygb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( muscle glycogen phosphorylase ) or ( liver glycogen phosphorylase ) or ( brain glycogen phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMPKI__45__RXN" name="Cytidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cmpk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine monophosphate (UMP-CMP) kinase 1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMP__45__N__45__ACETYL__45__NEURAMINATE_TO_CMP_COF_RXN" name="CMP-N-ACETYL-NEURAMINATE_TO_CMP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CMP__45__N__45__ACETYL__45__NEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRS__45__RXN" name="phosphoribosylformylglycinamidine cyclo-ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gart )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROPRIBTRANS__45__RXN" name="Orotate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Umps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine monophosphate synthetase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__5__45__RXN" name="3-oxo-5-&amp;alpha;-steroid 4-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Srd5a2 ) or ( Srd5a1 ) or ( Srd5a3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid 5 alpha-reductase 2 ) or ( steroid 5 alpha-reductase 1 ) or ( steroid 5 alpha-reductase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Oxo__45__5__45__Alpha__45__Steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Oxo__45__Delta__45__4__45__Steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__102__45__RXN" name="&amp;beta;-1,3-galactosyl-O-glycosyl-glycoprotein &amp;beta;-1,6-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Gcnt1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosaminyl (N-acetyl) transferase 1, core 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.102</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GALACTOSAMINY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__16__45__N__45__ACETYL__45__D" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_SUC__45__COA_COF_RXN" name="CO-A_TO_SUC-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PURIDYLTRANS__45__RXN" name="UTP--glucose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose pyrophosphorylase 2 )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis (from UDP-D-Glucose)</html:p>
<html:p>SUBSYSTEM: Vitamin C biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-glucose conversion</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FOLYLPOLYGLUTAMATESYNTH__45__RXN" name="folylpolyglutamate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fpgs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamyl synthetase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__LYASE__45__RXN" name="Hydroxymethylglutaryl-CoA lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hmgcl ) or ( Hmgcll1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl-Coenzyme A lyase ) or ( 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 )</html:p>
<html:p>SUBSYSTEM: leucine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROL__45__ESTERASE__45__RXN" name="Sterol esterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Lipn ) or ( Cel ) or ( Lipa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipase, family member N ) or ( carboxyl ester lipase ) or ( lysosomal acid lipase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Steryl__45__Esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Sterols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__43____45__ADP__45__RIBOSYLTRANSFERASE__45__RXN" name="NAD(+) ADP-ribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Parp2 ) or ( Parp9 ) or ( Tnks2 ) or ( Parp8 ) or ( Parp1 ) or ( Parp6 ) or ( Tiparp ) or ( Parp12 ) or ( Parp14 ) or ( Parp16 ) or ( Parp11 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( poly (ADP-ribose) polymerase family, member 2 ) or ( poly (ADP-ribose) polymerase family, member 9 ) or ( tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 ) or ( poly (ADP-ribose) polymerase family, member 8 ) or ( poly (ADP-ribose) polymerase family, member 1 ) or ( poly (ADP-ribose) polymerase family, member 6 ) or ( TCDD-inducible poly(ADP-ribose) polymerase ) or ( poly (ADP-ribose) polymerase family, member 12 ) or ( poly (ADP-ribose) polymerase family, member 14 ) or ( poly (ADP-ribose) polymerase family, member 16 ) or ( poly (ADP-ribose) polymerase family, member 11 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.30</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__ADP__45__D__45__Ribosyl__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="__40__ADP__45__D__45__RIBOSYL__41____40__N__41____45__ACCEPTOR" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__ADP__45__D__45__Ribosyl__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="__40__ADP__45__D__45__RIBOSYL__41____40__N__43__1__41____45__ACCEPTOR" stoichiometry="1"/>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDLIPOXN__45__RXN" name="Dihydrolipoamide dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Dld )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrolipoamide dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Bcat1 ) or ( Bcat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched chain aminotransferase 1, cytosolic ) or ( branched chain aminotransferase 2, mitochondrial )</html:p>
<html:p>SUBSYSTEM: leucine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARG__45__OXIDATION__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Il4i1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( interleukin 4 induced 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__824" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DLACTDEHYDROGFAD__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ldhd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-lactate dehydrogenase (cytochrome) activity )</html:p>
<html:p>SUBSYSTEM: aerobic respiration -- electron donors reaction list</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3443" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh2 ) or ( Aldh9a1 ) or ( Aldh3a2 ) or ( Aldh7a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 2, mitochondrial ) or ( aldehyde dehydrogenase 9, subfamily A1 ) or ( aldehyde dehydrogenase family 3, subfamily A2 ) or ( aldehyde dehydrogenase family 7, member A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TESTOSTERONE__45__17__45__BETA__45__DEHYDROGENASE__45__RXN" name="Testosterone 17-&amp;beta;-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( H2-Ke6 ) or ( Hsd17b6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( H2-K region expressed gene 6 ) or ( hydroxysteroid (17-beta) dehydrogenase 6 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.63</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TESTOSTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ANDROST4ENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3701" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Pgk1 ) or ( Fnta ) or ( Pggt1b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate kinase 1 ) or ( farnesyltransferase, CAAX box, alpha ) or ( protein geranylgeranyltransferase type I, beta subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.59</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
      <speciesReference species="PROTEIN__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__GERANYLGERANYL__45__PROTEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAMDECARB__45__RXN" name="Adenosylmethionine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Amd1 ) or ( Amd2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine decarboxylase 1 ) or ( S-adenosylmethionine decarboxylase 2 )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.50</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OXIDIZED__45__DITHIOTHREITOL_TO_DITHIOTHREITOL_COF_RXN" name="OXIDIZED-DITHIOTHREITOL_TO_DITHIOTHREITOL_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__DITHIOTHREITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DITHIOTHREITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CORTISONE__45__BETA__45__REDUCTASE__45__RXN" name="Cortisone &amp;beta;-reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1d1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1, member D1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__287" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CORTISONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTEAMINE__45__DIOXYGENASE__45__RXN" name="Cysteamine dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Ado )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-aminoethanethiol (cysteamine) dioxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__239" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOTAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHYLGLYCINE__45__DEHYDROGENASE__45__RXN" name="Dimethylglycine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dmgdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dimethylglycine dehydrogenase precursor )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
