<?xml version="1.0"  encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="METEX155_metabolic_network_metabolic_network" name="Methylobacterium extorquens">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
  <species id="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" name="hydroxymethylpyrimidine phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Monophosphates__124__" name="a ribonucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7221" name="3-cis-dodecenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7222" name="2-trans-dodecenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7224" name="N-acetyl-L-citrulline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Amino__45__Acids__124__" name="a D-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARACHIDIC_ACID" name="arachidate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__DNA__45__Segment__45__in__45__Reverse__45__Orientations__124__" name="a DNA segment in reverse orientation" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GAMMA__45__GLUTAMYLCYSTEINE" name="L-&amp;gamma;-glutamylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP" name="guanosine-5&apos;-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1086" name="5-amino-6-(5&apos;-phosphoribitylamino)uracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="APS" name="adenosine 5&apos;-phosphosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" name="an L-1-phosphatidyl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SEDOHEPTULOSE__45__7__45__P" name="D-sedoheptulose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__110" name="salicylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROFOLATE" name="7,8-dihydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acceptor__124__" name="an oxidized electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ILE" name="L-isoleucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINAMINE" name="S-adenosyl-L-methioninamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__N__45__Carbamoyl__45__D__45__Amino__45__Acids__124__" name="an N-carbamoyl D-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__CYSTEINE" name="D-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARG" name="L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__CHLORO__45__24__45__DINITROBENZENE" name="1-chloro-2,4-dinitrobenzene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BISOHMYR__45__GLC" name="lipid A disaccharide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__882" name="1,6-anhMurNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMP" name="inosine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TARTRONATE__45__S__45__ALD" name="tartronate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6972" name="o-succinylbenzoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7418" name="coumarinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__ETCETERA__45__GLUCOSAMINYLDIPHOSPHOUND" name="prenyl-P-P-GlcNAc-ManNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7417" name="cis-coumarinic acid-&amp;beta;-D-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ" name="2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD1G__45__277" name="cerotoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ALLANTOIN" name="S-allantoin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__335" name="(R)-3-hydroxybutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" name="4-amino-4-deoxychorismate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOAMIDE" name="lipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" name="a protein L-&amp;beta;-isoaspartate &amp;alpha;-methyl ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" name="formyl-L-methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ASPARTATE" name="L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ASN" name="L-asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BENZOATE" name="benzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__8" name="ubiquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__9" name="ubiquinone-9" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CYSTATHIONINE" name="cystathionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Donor__45__H2__124__" name="a reduced electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACRYLATE" name="acrylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" name="6,7-dimethyl-8-(1-D-ribityl)lumazine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL" name="pyridoxal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" name="D-myo-inositol (3)-monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TREHALOSE__45__6P" name="trehalose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7408" name="phytofluene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" name="2-octaprenyl-6-hydroxyphenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7005" name="geranylgeranyl-chlorophyll a" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7006" name="tetrahydrogeranylgeranyl-chlorophyll a" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7003" name="tetrahydrogeranylgeranyl-PP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7004" name="dihydrogeranylgeranyl-chlorophyll a" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7002" name="dihydrogeranylgeranyl-PP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATP" name="ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" name="UDP-N-acetyl-D-galactosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALYL__45__COA" name="oxalyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Long__45__Chain__45__Polyphosphate__124__" name="long chain polyphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MG__45__PROTOPORPHYRIN" name="Mg-protoporphyrin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSE" name="&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7000" name="isobutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__318" name="monodehydroascorbate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOLLATE" name="glycolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH__45__P__45__OR__45__NOP" name="NAD(P)H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" name="dTDP-4-dehydro-6-deoxy-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDPDIACYLGLYCEROL" name="a CDP-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__LACTATE" name="D-lactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Monophosphates__124__" name="a nucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8199" name="a mismatched DNA base pair" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" name="a 2,3,4-saturated fatty acyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CANAVANINE" name="L-canavanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__PROPIONYL__45__COA" name="3-hydroxypropionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__1__45__ARSENATE" name="ribose-1-arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROKAEMPFEROL__45__CMPD" name="dihydrokaempferol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__3__45__HYDROXYACYL__45__COA" name="a (3S)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TYR" name="L-tyrosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARSENATE" name="arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5678__45__TETRAHYDROPTERIDINE" name="5,6,7,8-tetrahydropteridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" name="3-deoxy-D-arabino-heptulosonate-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THREO__45__DS__45__ISO__45__CITRATE" name="D-isocitrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE" name="N-acetyl-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LYS" name="L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENYLOSUCC" name="adenylo-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8181" name="DNA with lesion resolved through Rec-mediated pathway" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8180" name="DNA with lesion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__341" name="indole-3-ethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__AP__45__Site__45__Created__124__" name="an AP(apurinic or apyrimidinic) site created by glycosylic bond cleavage" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUMP" name="dUMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" name="4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALO__45__SUCCINATE" name="oxalosuccinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOPORPHYRIN_IX" name="protoporphyrin IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" name="an unsulfurated sulfur acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KDO__45__8P" name="3-deoxy-D-manno-octulosonate 8-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALLO__45__THR" name="allothreonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UROPORPHYRINOGEN__45__III" name="uroporphyrinogen-III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C4" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl- D-alanyl-D-alanine-diphosphoundecaprenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C3" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OH__45__MYRISTOYL" name="UDP-2,3-bis(3-hydroxymyristoyl)glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C6" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C5" name="N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROPIONYL__45__P" name="propionyl-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCERATE" name="D-glycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__377" name="2-keto-L-gulonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7035" name="2-phenylethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7037" name="methionol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7036" name="3-methylthiopropanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__MERCAPTO__45__PYRUVATE" name="3-mercaptopyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7031" name="3-methylbutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7032" name="3-methylbutanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7033" name="2-methylbutanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LINOLEIC_ACID" name="linoleate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C1" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANOSINE__45__5DP__45__3DP" name="ppGpp" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHENYLTETRAHYDROMETHANOPTERIN" name="5,10-methenyltetrahydromethanopterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__10576" name="4-chlorosalicylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BISOHMYR__45__GLUCOSAMINYL__45__1P" name="2,3-bis(3-hydroxymyristoyl)-&amp;beta;-D-glucosaminyl 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" name="1-(o-carboxyphenylamino)-1&apos;-deoxyribulose-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRANS__45__POLYISOPRENYL__45__PP" name="a trans-polyisoprenyln-PP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Amineated__45__Amine__45__Donors__124__" name="an amineated amine donor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXY__45__ACETONE__45__PHOSPHATE" name="dihydroxyacetone phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYDROXYMETHYLBILANE" name="hydroxymethylbilane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Triphosphates__124__" name="a nucleoside triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SQUALENE" name="squalene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC" name="&amp;beta;-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OCTAPRENYL__45__METHYL__45__OH__45__METHOXY__45__BENZQ" name="3-demethylubiquinol-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6994" name="eriodictyol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TARTRATE" name="L-tartrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7836" name="myristate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6991" name="(2S)-pinocembrin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6992" name="(2R,3R)-pinobanksin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Carboxylates__124__" name="a carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__191" name="&amp;alpha;-D-galactosyl-diphosphoundecaprenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__RIBAZOLE" name="&amp;alpha;-ribazole" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HISTIDINAL" name="histidinal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1148" name="N,N&apos;-dimethyl-p-phenylenediamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__785" name="5-carboxy-2-oxohept-3-enedioate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__195" name="octanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__196" name="octanoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__MALEYL__45__ACETOACETATE" name="4-maleyl-acetoacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1147" name="methyl red" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__SULFINYL__45__PYRUVATE" name="3-sulfinyl-pyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAMINE" name="pyridoxamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="QUINOLINATE" name="quinolinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Kanamycin__45__3__45__phosphates__124__" name="a kanamycin-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__582" name="molybdopterin guanine dinucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Quinones__124__" name="a quinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYLCOBALAMIN" name="coenzyme B12" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Fatty__45__Acids__124__" name="a fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__D__45__GALACTOSE" name="&amp;alpha;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ETHYL__45__2__45__METHYLACETOACETATE" name="ethyl-2-methylacetoacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1159" name="3,5-tetradecadienoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOIC__45__ACID" name="lipoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__S__45__Substituted__45__Glutathione__124__" name="a glutathione-toxin conjugate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1156" name="methyl-1,4-benzoquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1157" name="methyl-1,4-benzoquinol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1158" name="3,5-tetradecadienoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYGUANOSINE" name="deoxyguanosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="LAUROYLCOA__45__CPD" name="lauroyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8625" name="peptidylproline (&amp;omega; = 0)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DCTP" name="dCTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHYLENETETRAHYDROMETHANOPTERIN" name="5,10-methylene-tetrahydromethanopterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYNUCLEOTIDESM" name="(deoxynucleotides)(m)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <reaction id="GST__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2313 ) or ( META1_4937 ) or ( META1_2245 ) or ( META1_5215 ) or ( META1_4442 ) or ( META1_3345 ) or ( META1_2388 ) or ( META1_4414 ) or ( META1_2830_maiA ) or ( META1_3210 ) or ( META1_1798 ) or ( META1_5324 ) or ( META1_3680 ) or ( META1_4147 ) or ( META1_2720 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( maleylacetoacetate isomerase (glutathione S-transferase) ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__CHLORO__45__24__45__DINITROBENZENE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="S__45__24__45__DINITROPHENYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0175_ilvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ketol-acid reductoisomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R547__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__868" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__869" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRAISOM__45__RXN" name="Phosphoribosylanthranilate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0050_trpF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoribosylanthranilate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.24</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__NH3__45__RXN" name="GMP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3135_guaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GMP synthetase (glutamine aminotransferase)//GMP-SYN-GLUT-RXN )</html:p>
<html:p>SUBSYSTEM: guanosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTRACE__45__RXN" name="Glutamate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3428_murI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate racemase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUC__45__COA_TO_CO__45__A_COF_RXN" name="SUC-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__969" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0694 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycolate oxidase (glcD-like), FAD-linked subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATE__45__SYNTHASE__45__RXN" name="Chorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3197_aroC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chorismate synthase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.5</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLHOMOSER__45__CYS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2508_metY ) or ( META1_5055_metY ) or ( META1_3547_metY ) or ( META1_3362_metY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase)//O-acetylhomoserine aminocarboxypropyltransferase ) or ( trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase)//O-acetylhomoserine aminocarboxypropyltransferase ) or ( Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase)//O-acetylhomoserine aminocarboxypropyltransferase ) or ( trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase)//O-acetylhomoserine aminocarboxypropyltransferase )</html:p>
<html:p>SUBSYSTEM: homocysteine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.49</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HIPPURATE__45__HYDROLASE__45__RXN" name="Hippurate hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2885 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peptidase M20D, amidohydrolase (degradation of proteins, peptides and glycopeptides )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.32</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__425" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSDECARBOX__45__RXN" name="Lysine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2027 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ornithine/diaminopimelate PLP-dependent decarboxylase )</html:p>
<html:p>SUBSYSTEM: lysine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.18</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CADAVERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSE6PSYN__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1441_otsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha,alpha-trehalose-phosphate synthase (UDP-forming); osmoregulatory trehalose synthesis protein A//TREHALOSE6PSYN-RXN )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.15</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTEROATESYNTH__45__RXN" name="Dihydropteroate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1745_folP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7,8-dihydropteroate synthase (dihydropteroate synthase (DHPS), dihydropteroate pyrophosphorylase)//H2PTEROATESYNTH-RXN )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.15</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CPM__45__KDOSYNTH__45__RXN" name="3-deoxy-manno-octulosonate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0233_kdsB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-manno-octulosonate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.38</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="KDO" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__4355" name="3-oxoacyl-[acyl-carrier protein] synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3203_pccA ) or ( META1_0172_pccB ) or ( META1_0025_mdcD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( propionyl-CoA carboxylase alpha subunit ) or ( propionyl-CoA carboxylase beta chain ) or ( malonate decarboxylase, beta-subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__277" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__332" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLN_TO_GLT_COF_RXN" name="GLN_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAICARSYN__45__RXN" name="Phosphoribosylaminoimidazole-succinocarboxamide synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0412_purC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole-succinocarboxamide synthetase (SAICAR synthetase)//SAICARSYN-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCDIAMINOPIMDESUCC__45__RXN" name="Succinyl-diaminopimelate desuccinylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1527_dapE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-succinyl-diaminopimelate deacylase (dapE)//SUCCDIAMINOPIMDESUCC-RXN )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.18</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__SUCCINYLLL__45__2__45__6__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMYLOMALT__45__RXN" name="4-&amp;alpha;-glucanotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2905 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative malto-oligosyltrehalose synthase )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATPPHOSPHORIBOSYLTRANS__45__RXN" name="ATP phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1389_hisG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.17</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP_TO_GDP__45__MANNOSE_COF_RXN" name="GDP_TO_GDP-MANNOSE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4281" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2002_dkgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,5-diketo-D-gluconate reductase A//1.1.1.274-RXN//RXN0-1941 )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__HEXAPRENYLTRANSTRANSFERASE__45__RXN" name="all-trans-heptaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: heptaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.30</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R314__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0687 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amidase )</html:p>
<html:p>SUBSYSTEM: aldoxime degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AGMATIN__45__RXN" name="Agmatinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4303 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( agmatinase (ureohydrolase) )</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine degradation III (arginine decarboxylase/agmatinase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AGMATHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__271__45__RXN" name="GDP-L-fucose synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5071_fcl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase; GDP-4-dehydro-6-L-deoxygalactose reductase//1.1.1.271-RXN )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.271</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__PENTAPRENYLTRANSFERASE__45__RXN" name="all-trans-hexaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: heptaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.33</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDRODIPICSYN__45__RXN" name="dihydrodipicolinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3403_dapA ) or ( META1_0521 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrodipicolinate synthase ) or ( putative dihydrodipicolinate synthase (dapA-like) )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.52</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCOSE_TO_UDP_COF_RXN" name="UDP-GLUCOSE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDP__45__GLUCOSE__45__46__45__DEHYDRATASE__45__RXN" name="CDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0613_rfbG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cdp-glucose 4,6-dehydratase )</html:p>
<html:p>SUBSYSTEM: CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.45</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__658" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5308 ) or ( META1_0795 ) or ( META1_1682_ggt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative gamma-glutamyltranspeptidase ) or ( putative gamma-glutamyltranspeptidase ) or ( gamma-glutamyltranspeptidase//GAMMA-GLUTAMYLTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
      <speciesReference species="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG6PDEACET__45__RXN" name="N-acetylglucosamine-6-phosphate deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4722 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative N-acetylglucosamine-6-phosphate deacetylase (nagA-like)//N-acetylglucosamine-6-phosphate deacetylase )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXY__45__OXOHEPT__45__ENEDIOATE__45__DECARBOXY__45__RXN" name="5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4396_hpaG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxyhepta-2,4-diene-1, 7-dioate isomerase/5-carboxymethyl-2-oxo- hex-3-ene-1, 7-dioate decarboxylase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.68</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__785" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__787" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSNACMURPENTATRANS__45__RXN" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5085_mraY ) or ( META1_2015 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phospho-N-acetylmuramoyl-pentapeptide-transferase ) or ( putative glycosyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
      <speciesReference species="C1" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C5" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMPCYCLOHYDROLASE__45__RXN" name="IMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2535_purH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal)//AICARTRANSFORM-RXN//IMPCYCLOHYDROLASE-RXN//IMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7793" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0541 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ceramide glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.80</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Glucosyl__45__Ceramides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1382" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0999_frc ) or ( META1_5097 ) or ( META1_0988_frc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formyl-CoA transferase, NAD(P)-binding//RXN0-1382 ) or ( putative L-carnitine dehydratase; putative acyl-CoA-transferase, NAD(P)-binding ) or ( formyl-CoA transferase, NAD(P)-binding//RXN0-1382 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALATE" stoichiometry="1"/>
      <speciesReference species="FORMYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALYL__45__COA" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HALOACETATE__45__DEHALOGENASE__45__RXN" name="Haloacetate dehalogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4241 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alpha/beta hydrolase, putative haloacetate dehalogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Haloacetates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Halides__124__" stoichiometry="1"/>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNP__45__RXN" name="Purine-nucleoside phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3170_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENMETSYN__45__RXN" name="Methionine adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3521_metK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methionine adenosyltransferase 1 (AdoMet synthetase)//S-ADENMETSYN-RXN )</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANIDINOBUTANAMIDE__45__NH3__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0687 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__GUANIDO__45__BUTYRAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__592" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R22__45__RXN" name="Butyryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4494 ) or ( META1_3456_fadE ) or ( META1_0946 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( Acyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__DEHYDROPANTOATE__45__REDUCT__45__RXN" name="2-dehydropantoate 2-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2129 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-dehydropantoate 2-reductase (ketopantoate reductase)//2-dehydropantoate 2-reductase )</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.169</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOX__45__RXN" name="Sarcosine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4108_soxB ) or ( META1_1548_soxB ) or ( META1_4110_soxA ) or ( META1_1547 ) or ( META1_4111_soxG ) or ( META1_4109_soxD ) or ( META1_1545 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sarcosine oxidase, beta subunit ) or ( sarcosine oxidase beta subunit ) or ( sarcosine oxidase, alpha subunit ) or ( putative sarcosine oxidase, delta subunit ) or ( sarcosine oxidase, gamma subunit ) or ( sarcosine oxidase, delta subunit ) or ( putative sarcosine oxidase, gamma subunit )</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADOMET__45__DMK__45__METHYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4311_ubiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ubiquinone/menaquinone biosynthesis methyltransferase ubiE )</html:p>
<html:p>SUBSYSTEM: menaquinone-8 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEMETHYLMENAQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VITAMIN_K_2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__II__45__RXN" name="GTP cyclohydrolase II" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3198_ribAB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.25</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0211_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline dehydrogenase PutA//RXN-821 )</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSOPHOSPHOLIPASE__45__RXN" name="Lysophospholipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5006 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative lysophospholipase L2 (pldB-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__GLYCERO__45__PHOSPHORYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHACYL__45__COA__45__DEHYDROG__45__RXN" name="3-hydroxyacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3452 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OXALATE__45__DECARBOXYLASE__45__RXN" name="Oxalate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0218_oxdC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxalate decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="EXOPOLYPHOSPHATASE__45__RXN" name="Exopolyphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2050 ) or ( META1_3662 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( exopolyphosphatase ) or ( exopolyphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DLACTDEHYDROGNAD__45__RXN" name="D-lactate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4794_ldhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fermentative D-lactate dehydrogenase, NAD-dependent//DLACTDEHYDROGNAD-RXN//D-lactate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.28</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__262__45__RXN" name="4-hydroxythreonine-4-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3894_pdxA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxythreonine-4-phosphate dehydrogenase (4-(phosphohydroxy)-L-threonine dehydrogenase)//1.1.1.262-RXN//4-hydroxythreonine-4-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.262</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETPYRKIN__45__RXN" name="Hydroxymethylpyrimidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4915_thiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase)//OHMETPYRKIN-RXN//PYRIMSYN3-RXN )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.49</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOCHLOROPHYLLIDE__45__REDUCTASE__45__RXN" name="Protochlorophyllide reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5273_bchN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protochlorophyllide reductase subunit BchN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.33</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MONO__45__VINYL__45__PROTOCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PDXJ__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2271_pdxJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyridoxal phosphate biosynthetic protein pdxJ (PNP synthase) )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.6.99.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="_1__45__AMINO__45__PROPAN__45__2__45__ONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__69__45__RXN" name="Protein-N(PI)-phosphohistidine-sugar phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1020 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative PTS system subfamily mannose/fructose-specific IIA component )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sugar__124__" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
      <speciesReference species="__124__Sugar__45__Phosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" name="L-ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OXOACID__45__COA__45__TRANSFERASE__45__RXN" name="3-oxoacid CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2054 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Acyl CoA:acetate/3-ketoacid CoA transferase; fused alpha subunit and beta subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__3__45__OXO__45__ACID" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVIN__45__SYN__45__RXN" name="Riboflavin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3375_ribE ) or ( META1_3380_ribE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (Lumazine synthase) (Riboflavin synthase beta chain)//Riboflavin synthase ) or ( riboflavin synthase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP_TO_UTP_COF_RXN" name="UDP_TO_UTP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_THF_COF_RXN" name="METHYLENE-THF_TO_THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4888_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional folylpolyglutamate synthase and dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IGPSYN__45__RXN" name="indole-3-glycerol-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5121_trpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indole-3-glycerol phosphate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.48</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCROSE__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="Sucrose-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0091 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Conserved hypothetical protein; putative HAD superfamily hydrolase; putative glycosyl transferase )</html:p>
<html:p>SUBSYSTEM: sucrose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.14</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: FRUCTOSE__45__6P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCROSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Ubiquinones__124___TO___124__Ubiquinols__124___COF_RXN" name="|Ubiquinones|_TO_|Ubiquinols|_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Ubiquinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ubiquinols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THI__45__P__45__KIN__45__RXN" name="Thiamine-phosphate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3373_thiL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamin-monophosphate kinase//THI-P-KIN-RXN )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.16</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_DIHYDROFOLATE_COF_RXN" name="METHYLENE-THF_TO_DIHYDROFOLATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UGD__45__RXN" name="UDP-glucose 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3235_ugdH ) or ( META1_1822_ugdH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose-6-dehydrogenase ) or ( UDP-glucose-6-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-D-xylose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYBENZOYLFORMATE__45__DECARBOXYLASE__45__RXN" name="Benzoylformate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2494 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative decarboxylase, Thiamine pyrophosphate-requiring )</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.7</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__142" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXYBENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERCAPYSTRANS__45__RXN" name="3-mercaptopyruvate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2537_sseA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-mercaptopyruvate sulfurtransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCN" stoichiometry="1"/>
      <speciesReference species="_3__45__MERCAPTO__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HSCN" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4113" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3803 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Zn-containing alcohol dehydrogenase (adh) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDRPHENYLAC__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__4151" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROLINE__45__MULTI" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3072_proA ) or ( META1_3071_proB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gamma-glutamyl phosphate reductase (GPR) (Glutamate-5- semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase)//GLUTSEMIALDEHYDROG-RXN ) or ( Glutamate 5-kinase (Gamma-glutamyl kinase) (GK)//GLUTKIN-RXN//Glutamate 5-kinase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTAMINOTRANS__45__RXN" name="Histidinol-phosphate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1486_hisC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinol-phosphate aminotransferase//HISTAMINOTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.9</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALGLDAPLIG__45__RXN" name="UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5087_murE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2828_acnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitate hydratase//ACONITATEDEHYDR-RXN )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7775" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1642 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2OG-Fe(II) oxygenase superfamily )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.9</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6994" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__474" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDYLATE__45__SYNTHASE__45__RXN" name="Pseudouridylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0168 ) or ( META1_2277_rsuA ) or ( META1_0783_rluD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pseudouridine synthase, RluD ) or ( 16S rRNA pseudouridylate 516 synthase ) or ( ribosomal large subunit pseudouridine synthase D (Pseudouridylate synthase) (Uracil hydrolyase)//Pseudouridylate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.70</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHOSINEPHOSPHORY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3170_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__DELTA__45__ISOM__45__RXN" name="Dodecenoyl-CoA &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3452 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__DELTA3__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SALICYLATE__45__1__45__MONOOXYGENASE__45__RXN" name="Salicylate 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2195 ) or ( META1_0388 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative salicylate hydroxylase, Salicylate 1-monooxygenase, nahG//Salicylate 1-monooxygenase ) or ( Salicylate hydroxylase (Salicylate 1-monooxygenase)//Salicylate 1-monooxygenase )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__110" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4546_glmS ) or ( META1_4723 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-glutamine:D-fructose-6-phosphate aminotransferase//L-GLN-FRUCT-6-P-AMINOTRANS-RXN ) or ( putative Glucosamine-fructose-6-phosphate aminotransferase (gmlS-like) )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.16</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__HYDRAT__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4879 ) or ( META1_4632 ) or ( META1_3452 ) or ( META1_5098_croA ) or ( META1_3870 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase ) or ( putative enoyl-CoA hydratase/isomerase family protein ) or ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase ) or ( 3-hydroxybutyryl-CoA dehydratase ) or ( Enoyl-CoA hydratase/isomerase family protein//Enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PALMITYL__45__COA_TO_CO__45__A_COF_RXN" name="PALMITYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PALMITYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLGLUTKIN__45__RXN" name="Acetylglutamate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2345_argB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylglutamate kinase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7562" name="Acetylornithine aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4464_argD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinylornithine transaminase, also has acetylornitine transaminase activity, PLP-dependent )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.11</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__PEROXIDASE__45__RXN" name="glutathione peroxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0207 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glutathione peroxidase )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.9</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__3__46__9__45__RXN" name="Phosphoenolpyruvate--protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0731_ptsP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoenolpyruvate-protein phosphotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.3.9</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXI__45__RXN" name="Lactoylglutathione lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4683 ) or ( META1_3100 ) or ( META1_0359 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative lactoylglutathione lyase ) or ( lactoylglutathione lyase family protein ) or ( putative lactoylglutathione lyase )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.5</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8675" name="Uroporphyrinogen-III C-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3434_cysG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Siroheme synthase//DIMETHUROPORDEHYDROG-RXN//RXN-8675//SIROHEME-FERROCHELAT-RXN//UROPORIIIMETHYLTRANSA-RXN )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8674" name="Glycine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0430_thiO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10490" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
      <speciesReference species="ETHANAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__NUCLEOSID__45__RXN" name="AMP nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0535_amn )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AMP nucleosidase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE__45__5P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENDECARBOX__45__RXN" name="Uroporphyrinogen decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1385_hemE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen decarboxylase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.37</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYM__45__PHOSPH__45__RXN" name="Thymidine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3168_deoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine phosphorylase//THYM-PHOSPH-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="THYMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIMSYN3__45__RXN" name="Phosphomethylpyrimidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4915_thiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: hydroxy-methylpyrimidine kinase (HMP kinase); hydroxy-phosphomethylpyrimidine kinase (HMP-P kinase)//OHMETPYRKIN-RXN//PYRIMSYN3-RXN )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.7</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPSYN__45__RXN" name="Tryptophan synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4890_trpA ) or ( META1_0049_trpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase alpha subunit//TRYPSYN-RXN ) or ( tryptophan synthase, beta protein//RXN0-2382//TRYPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__32__45__RXN" name="Geranylgeranyl-diphosphate geranylgeranyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1815 ) or ( META1_3220_crtB ) or ( META1_1816 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phytoene synthase ) or ( phytoene synthase ) or ( putative phytoene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.32</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__464" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TSA__45__REDUCT__45__RXN" name="2-hydroxy-3-oxopropionate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2846 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-hydroxy-3-oxopropionate reductase//2-hydroxy-3-oxopropionate reductase )</html:p>
<html:p>SUBSYSTEM: D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.60</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLY3KIN__45__RXN" name="Glycerate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2944_gck ) or ( META1_2748 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerate kinase ) or ( putative glycerate kinase )</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.31</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7958" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1891 ) or ( META1_3807 ) or ( META1_0383 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acetate kinase, propionate kinase ) or ( putative acetate kinase (partial) ) or ( putative acetate kinase (ackA) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1990_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3803 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Zn-containing alcohol dehydrogenase (adh) )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to ethanol II</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5985" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4394_bioB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthetase//2.8.1.6-RXN )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5662" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5984" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4394_bioB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthetase//2.8.1.6-RXN )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__5662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__20" name="Magnesium chelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2470_bchI ) or ( META1_5271_bchH ) or ( META1_3217_bchD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mg chelatase subunit Bchl, participate to introduce Mg in bacteriochlorophyl with BchH and BchD ) or ( magnesium-protoporphyrin O-methyltransferase BchH subunit ) or ( magnesium chelatase subunit BchD )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.6.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: MG__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MG__43__2" stoichiometry="1"/>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MG__45__PROTOPORPHYRIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__87__45__RXN" name="N-carbamoyl-L-amino-acid hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4124 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amidase, hydantoinase/carbamoylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.87</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Carbamoyl__45__L__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__2__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DETHIOBIOTIN__45__SYN__45__RXN" name="dethiobiotin synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2335_bioD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dethiobiotin synthetase (Dethiobiotin synthase) (DTB synthetase) (DTBS)//DETHIOBIOTIN-SYN-RXN//Dethiobiotin synthase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGINASE__45__RXN" name="Arginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0363_rocF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase (arginine amidinase) )</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation VII (arginase 3 pathway)</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMDECARB__45__RXN" name="Diaminopimelate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1718_lysA ) or ( META1_3654 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaminopimelate decarboxylase ) or ( putative ornithine/diaminopimelate PLP-dependent decarboxylase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.20</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLATECYC__45__RXN" name="Adenylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3294_cyaA ) or ( META1_0431 ) or ( META1_3400 ) or ( META1_5234 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenylate/guanylate cyclase ) or ( putative Adenylate/Guanylate cyclase ) or ( Putative adenylate cyclase protein ) or ( putative transmembrane adenylate/guanylate cyclase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7929" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2137 ) or ( META1_4295 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family ) or ( putative carbon-carbon lyase, HpcH/HpaI aldolase/citrate lyase family )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.34</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3S__45__CITRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASCORBATE__45__OXIDASE__45__RXN" name="L-ascorbate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1911 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multicopper oxidase, putative manganese-oxidizing multicopper oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASCORBATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACSERLY__45__RXN" name="Cysteine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1278_cysK ) or ( META1_0751_cysK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cysteine synthase ) or ( subunit of cysteine synthase A and O-acetylserine sulfhydrolase A, PLP-dependent enzyme//ACSERLY-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.47</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8672" name="Glycine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0430_thiO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8673" name="Glycine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0430_thiO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLAMINE" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCHOMOSERLYASE__45__RXN" name="O-succinylhomoserine (thiol)-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3060 ) or ( META1_3766 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cystathionine gamma-synthase, PLP-dependent (metB) ) or ( cystathionine gamma-synthase, PLP-dependent )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.48</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIB5PISOM__45__RXN" name="Ribose 5-phosphate epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2299_rpiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ribose-5-phosphate isomerase A//RIB5PISOM-RXN//Ribose-5-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCDEHYDROG__45__RXN" name="Glucose dehydrogenase (pyrroloquinoline-quinone)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4884_yliI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PQQ-dependent aldose sugar dehydrogenase precursor (asd), signal peptide//GLUCDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.5.2</html:p>
<html:p>COFACTOR: __124__Ubiquinols__124__</html:p>
<html:p>COFACTOR: __124__Ubiquinones__124__</html:p>
<html:p>SIDE: __124__Ubiquinols__124__</html:p>
<html:p>SIDE: __124__Ubiquinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__O__45__ACETTRAN__45__RXN" name="Serine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0953_cysE ) or ( META1_2100_cysE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine acetyltransferase//SERINE-O-ACETTRAN-RXN ) or ( serine acetyltransferase//SERINE-O-ACETTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.30</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZOYLFORMATE__45__DECARBOXYLASE__45__RXN" name="Benzoylformate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2494 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative decarboxylase, Thiamine pyrophosphate-requiring )</html:p>
<html:p>SUBSYSTEM: mandelate degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.7</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPOXANPRIBOSYLTRAN__45__RXN" name="Hypoxanthine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3063_hpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hypoxanthine phosphoribosyl transferase//GUANPRIBOSYLTRAN-RXN//HYPOXANPRIBOSYLTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__121__45__RXN" name="Phosphoenolpyruvate--glycerone phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0796_dhaK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydroxyacetone kinase (Glycerone kinase)//Glycerone kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.121</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7931" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3452 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7221" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONDEHYDROG__45__RXN" name="Phosphogluconate dehydrogenase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1863_gnd ) or ( META1_5283_gnd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase//6PGLUCONDEHYDROG-RXN ) or ( 6-phosphogluconate dehydrogenase//6PGLUCONDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2235_panC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme)//PANTOATE-BETA-ALANINE-LIG-RXN//Pantoate--beta-alanine ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOYL__45__LACTONE" stoichiometry="1"/>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7933" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0283_argE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine deacetylase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7224" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7706" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3803 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Zn-containing alcohol dehydrogenase (adh) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7036" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7037" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANINE__45__DEAMINASE__45__RXN" name="Guanine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1653_guaD ) or ( META1_3348_guaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine deaminase ) or ( Guanine deaminase (Guanase) (Guanine aminase) (Guanine aminohydrolase) (GAH) (GDEase)//Guanine deaminase )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5375" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2017_azoR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FMN-dependent NADH-azoreductase (FMN-dependent NADH-azo compound oxidoreductase) (Azo-dye reductase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.6</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1147" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1148" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYL__45__KIN__45__RXN" name="Guanylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1978_gmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Guanylate kinase (GMP kinase)//GUANYL-KIN-RXN//Guanylate kinase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: guanosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7700" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3803 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Zn-containing alcohol dehydrogenase (adh) )</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7035" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPDEHYRHAMREDUCT__45__RXN" name="dTDP-4-dehydrorhamnose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2396_rfbD ) or ( META1_4040_rfbD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-4-dehydrorhamnose reductase ) or ( dTDP-4-dehydrorhamnose reductase )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.133</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__RHAMNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7908" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1736 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative transcriptional coactivator/pterin dehydratase )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.96</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1990_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: guanosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__269__45__RXN" name="2-(S)-hydroxypropyl-CoM dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Short chain dehydrogenase/reductase (gene fragment) )</html:p>
<html:p>SUBSYSTEM: propylene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.269</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__S__45__HYDROXYPROPYL__45__COM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOPROPYL__45__COM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5387" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1438 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative NADPH quinone oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1156" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1157" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7710" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2910_glgB ) or ( META1_1850_glgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,4-alpha-glucan branching enzyme ) or ( 1,4-alpha-glucan branching enzyme, glycogen synthesis//GLYCOGEN-BRANCH-RXN//1,4-alpha-glucan branching enzyme )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__5__45__DEHYDROGENASE__45__RXN" name="Shikimate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1380 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative shikimate 5-dehydrogenase (aroE) )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.25</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__132__45__RXN" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0799_cobL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-6Y C(5,15)-methyltransferase [decarboxylating] (Precorrin-6 methyltransferase) (Precorrin-6Y methylase) )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.132</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__679" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__686" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__ISOPROPYLMALATESYN__45__RXN" name="2-isopropylmalate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2867_leuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-isopropylmalate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.13</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHORIBULOKINASE__45__RXN" name="Phosphoribulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0758_prk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribulokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.19</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__RIBULOSE__45__15__45__P2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5284" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5263_acsF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aerobic magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase (aerobic Mg-protoporphyrin IX monomethyl ester oxidative cyclase) )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_131__45__OXO__45__MAGNESIUM__45__PROTOPORPHYRIN__45__IX__45__13__45__M" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIVINYL__45__PROTOCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5263_acsF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aerobic magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase (aerobic Mg-protoporphyrin IX monomethyl ester oxidative cyclase) )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_13__45__HYDROXY__45__MAGNESIUM__45__PROTOPORP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_131__45__OXO__45__MAGNESIUM__45__PROTOPORPHYRIN__45__IX__45__13__45__M" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5263_acsF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aerobic magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase (aerobic Mg-protoporphyrin IX monomethyl ester oxidative cyclase) )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MG__45__PROTOPORPHYRIN__45__MONOMETHYL__45__ESTER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_13__45__HYDROXY__45__MAGNESIUM__45__PROTOPORP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMEPIM__45__RXN" name="Diaminopimelate epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2917_dapF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Diaminopimelate epimerase (DAP epimerase)//DIAMINOPIMEPIM-RXN//Diaminopimelate epimerase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__19__45__RXN" name="Nucleoside-triphosphate pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4291_mazG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside triphosphate pyrophosphohydrolase MazG )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5395" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1057 ) or ( META1_4948 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycoside hydrolase ) or ( putative glycoside hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__BETA__45__D__45__GLUCOSYLGLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7919" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2476 ) or ( META1_4209 ) or ( META1_3640 ) or ( META1_1207 ) or ( META1_2584 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative hydroxyacylglutathione hydrolase (gloB-like) with metallo-hydrolase/oxidoreductase domain ) or ( putative hydroxyacylglutathione hydrolase, beta-lactamase domain protein ) or ( putative hydroxyacylglutathion hydrolase ) or ( beta-lactamase domain protein, putative hydroxyacylglutathione hydrolase ) or ( beta-lactamase domain protein, putative hydroxyacylglutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__hydroxyacyl__45__glutathiones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Hydroxy__45__carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7913" name="Cytidylate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2119_cmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine monophosphate (CMP) kinase//CMPKI-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5390" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5221_ybgC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase )</html:p>
<html:p>SUBSYSTEM: oleate &amp;beta;-oxidation</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1159" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYISOVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1928 ) or ( META1_2868_ilvD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dihydroxyacid dehydratase (ilvD-like) ) or ( dihydroxyacid dehydratase//DIHYDROXYISOVALDEHYDRAT-RXN//DIHYDROXYMETVALDEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5359" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4146 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative diguanylate cyclase (GGDEF) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.65</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C__45__DI__45__GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETHYLBILANESYN__45__RXN" name="Hydroxymethylbilane synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5307_hemC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Porphobilinogen deaminase (PBG) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase)//OHMETHYLBILANESYN-RXN//Hydroxymethylbilane synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.61</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINOALANINE__45__AMINOTRANSFERASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2702 ) or ( META1_3915 ) or ( META1_2053_aatA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate transaminase ) or ( aspartate aminotransferase ) or ( aspartate aminotransferase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.1</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__19__45__RXN" name="3-phosphoshikimate 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2118_aroA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-enolpyruvylshikimate-5-phosphate synthetase//2.5.1.19-RXN )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.19</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5364" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0694 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycolate oxidase (glcD-like), FAD-linked subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXYGLUTARIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPH__45__RXN" name="Phosphoglycolate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2297 ) or ( META2_0461 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoglycolate phosphatase, putative haloacid dehalogenase family hydrolase ) or ( putative Hydrolase (HAD superfamily) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__67" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__83__45__RXN" name="D-malate dehydrogenase (decarboxylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5136_ttuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating])//Tartrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.83</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__660" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOTHENATE__45__KIN__45__RXN" name="Pantothenate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2521_coaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantothenate kinase )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGEN__45__BRANCH__45__RXN" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2910_glgB ) or ( META1_1850_glgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,4-alpha-glucan branching enzyme ) or ( 1,4-alpha-glucan branching enzyme, glycogen synthesis//GLYCOGEN-BRANCH-RXN//1,4-alpha-glucan branching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5100" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p2META_0001_pin ) or (  ) or ( p2META_0012_pin ) or ( META1_0355_pin ) or ( p1META_0001_pin ) or ( META2_1078_pin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( site-specific DNA recombinase of ISMex22 ) or ( fragment of site-specific DNA recombinase of ISMex22 ) or ( site-specific DNA recombinase ) or ( site-specific DNA recombinase of ISMex22 ) or ( site-specific DNA recombinase of ISMex22 ) or ( site-specific DNA recombinase of ISMex22 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.99.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__Segments__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__DNA__45__Segment__45__in__45__Reverse__45__Orientations__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__MG__45__PROTOPORPHYRIN__45__METHYLESTER__45__SYN" name="Magnesium-protoporphyrin O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5269_bchM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mg-protoporphyrin IX methyl transferase )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.11</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MG__45__PROTOPORPHYRIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MG__45__PROTOPORPHYRIN__45__MONOMETHYL__45__ESTER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__6__45__METHOXYPHENOL__45__HYDROX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4277_ubiH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-octaprenyl-6-methoxyphenol hydroxylase (FAD-dependent oxidoreductase) )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.14.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__METHOXYPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__METHOXY__45__BENZOQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__44__45__RXN" name="Homospermidine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2024_hss )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homospermidine synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.44</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1821" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__CH3__45__2__45__OXOBUTANOATE__45__OH__45__CH3__45__XFER__45__RXN" name="3-methyl-2-oxobutanoate hydroxymethyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1701_panB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methyl-2-oxobutanoate hydroxymethyltransferase, pantothenate biosynthetic process//3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN//3-methyl-2-oxobutanoate hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.11</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: METHYLENE__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTCYCLOHYD__45__RXN" name="Phosphoribosyl-AMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2263_hisI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosyl c-AMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R321__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1327_cobG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin-3B synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.83</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__642" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__643" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__LACTAMASE__45__RXN" name="&amp;beta;-lactamase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4843 ) or ( META2_0052 ) or ( META1_1373_ampC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Beta-lactamase ) or ( Beta-lactamase family protein ) or ( beta-lactamase/D-ala carboxypeptidase; penicillin resistance, penicillin-binding protein (PBP)//BETA-LACTAMASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__Lactams__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8550" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9598" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4817 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative NAD binding site:Amine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Monoamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
      <speciesReference species="__124__Primary__45__Amines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNI__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2054 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Acyl CoA:acetate/3-ketoacid CoA transferase; fused alpha subunit and beta subunit )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>SIDE: _3__45__KETOBUTYRATE</html:p>
<html:p>SIDE: ACETOACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNI__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1401_mqo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate dehydrogenase, FAD/NAD(P)-binding domain (tat pathway signal)//MALATE-DEHYDROGENASE-ACCEPTOR-RXN )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: REDUCED__45__MENAQUINONE</html:p>
<html:p>SIDE: CPD__45__9728</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9728" stoichiometry="1"/>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
      <speciesReference species="REDUCED__45__MENAQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLT_TO_2__45__KETOGLUTARATE_COF_RXN" name="GLT_TO_2-KETOGLUTARATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R542__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3803 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Zn-containing alcohol dehydrogenase (adh) )</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__863" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__864" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEPHOSPHOCOAKIN__45__RXN" name="Dephospho-CoA kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1379_coaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dephospho-CoA kinase (dephosphocoenzyme A kinase)//DEPHOSPHOCOAKIN-RXN )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__11__46__1__46__15__45__RXN" name="Peroxiredoxin" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2715 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative peroxiredoxin protein, antioxidant protein, AhpC/TSA family protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="2"/>
      <speciesReference species="__124__Alkyl__45__Hydro__45__Peroxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3174_waaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-D-manno-octulosonic acid transferase )</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: KDO transfer to lipid IVA</html:p>
<html:p>PROTEIN_CLASS: 2.-.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LIPID__45__IV__45__A" stoichiometry="1"/>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO__45__LIPID__45__IVA" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPACYLGLCNACDEACETYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3155_lpxC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-3-O-acyl N-acetylglucosamine deacetylase )</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__OHMYR__45__ACETYLGLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="UDP__45__OHMYR__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULP3EPIM__45__RXN" name="ribulose phosphate 3-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0768_rpe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-ribulose-5-phosphate 3-epimerase//RIBULP3EPIM-RXN )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8470" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4977 ) or ( META1_0685 ) or ( META2_0885 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase precursor (tat pathway signal) ) or ( putative aldehyde dehydrogenase precursor (tat pathway signal) ) or ( Putative membrane-bound aldehyde dehydrogenase [pyrroloquinoline-quinone-linked] )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8660" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__5__46__1__45__RXN" name="Nitrilase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_1120 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nitrilase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nitriles__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINKIN__45__RXN" name="ATP-dependent riboflavin kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0335_ribF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative riboflavin biosynthesis protein ribF [Includes: Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)]//FADSYN-RXN//RIBOFLAVINKIN-RXN//FAD synthetase//Riboflavin kinase )</html:p>
<html:p>SUBSYSTEM: 5,6-dimethylbenzimidazole biosynthesis</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R123__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1649 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative N-isopropylammelide isopropylaminohydrolase )</html:p>
<html:p>SUBSYSTEM: atrazine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ISOPROPYLAMMELIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOPROPYLAMINE" stoichiometry="1"/>
      <speciesReference species="CYANURIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SIROHEME__45__FERROCHELAT__45__RXN" name="Sirohydrochlorin ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3434_cysG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Siroheme synthase//DIMETHUROPORDEHYDROG-RXN//RXN-8675//SIROHEME-FERROCHELAT-RXN//UROPORIIIMETHYLTRANSA-RXN )</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCHORMAT__45__RXN" name="Isochorismatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4227 ) or ( META1_1183 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Isochorismatase hydrolase//Isochorismatase ) or ( putative Isochorismatase hydrolase//Isochorismatase )</html:p>
<html:p>SUBSYSTEM: 2,3-dihydroxybenzoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOCHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRO__45__DIOH__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEHYDR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2828_acnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitate hydratase//ACONITATEDEHYDR-RXN )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-D-GLUCOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5114" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2848 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoserine phosphatase (serB-like) )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__99__46__17__45__RXN" name="Squalene--hopene cyclase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1818_shc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene-hopene-cyclase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOP__45__2229__45__ENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R223__45__RXN" name="long-chain-fatty-acid-CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3910_fadD ) or ( META2_0014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)//ACYLCOASYN-RXN ) or ( putative fatty-acid--CoA ligase (Acyl-CoA synthetase) )</html:p>
<html:p>SUBSYSTEM: octane oxidation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__196" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXKIN__45__RXN" name="Pyridoxal kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2863_pdxY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal kinase 2/pyridoxine kinase//PYRIDOXKIN-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPPSYN__45__RXN" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2496_ispA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase (farnesyl-diphosphate synthase)//FPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: geranyldiphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNCARBAMTRANSFER__45__RXN" name="Ornithine carbamoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4465_argF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine carbamoyltransferase )</html:p>
<html:p>SUBSYSTEM: citrulline degradation</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__FORMYL__45__THF__45__CYCLO__45__LIGASE__45__RXN" name="5-formyltetrahydrofolate cyclo-ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2364 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ligase (ygfA) )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDRAT__45__RXN" name="Prephenate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0232 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Prephenate dehydratase//Prephenate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.51</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINSYN__45__RXN" name="argininosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2294_argG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate synthase (citrulline-aspartate ligase)//ARGSUCCINSYN-RXN )</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6081" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_P__45__COUMAROYL__45__COA_COF_RXN" name="CO-A_TO_P-COUMAROYL-COA_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__COUMAROYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3170_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__131__45__RXN" name="Precorrin-3B C17-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1324_cobJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-3B C(17)-methyltransferase (Precorrin-3 methyltransferase) (Precorrin-3 methylase)//Precorrin-3B C(17)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.131</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__643" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__651" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__75__45__RXN" name="Poly(3-hydroxybutyrate) depolymerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4597_depB ) or ( META1_4189 ) or ( META1_1376 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PHB depolymerase ) or ( putative Poly(3-hydroxybutyrate) depolymerase ) or ( putative Poly(3-hydroxybutyrate) depolymerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.75</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHB" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8445" stoichiometry="1"/>
      <speciesReference species="PHB" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMETB12__45__RXN" name="5-methyltetrahydrofolate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1494_metH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase//HOMOCYSMETB12-RXN )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__156__45__RXN" name="Adenosylcobinamide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1336_cobP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional adenosylcobalamin biosynthesis protein cobP )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.156</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Triphosphates__124__" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Diphosphates__124__" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0955 ) or ( META1_4365_sufS ) or ( META1_4360_iscS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cysteine desulfurase ) or ( cysteine desulfurase ) or ( cysteine desulfurase (tRNA sulfurtransferase), PLP-dependent )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.7</html:p>
<html:p>SIDE: PROT__45__CYS</html:p>
<html:p>SIDE: ENZYME__45__S__45__SULFANYLCYSTEINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ENZYME__45__S__45__SULFANYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1440_glgX ) or ( META1_3351_glgX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycosyl hydrolase (Debranching enzyme) ) or ( glycogen debranching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__305" name="Hydroxypyruvate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4594_hyi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxypyruvate isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__302" name="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3018_ispDF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IspD/IspF bifunctional enzyme (2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase (MEP cytidylyltransferase, MCT); 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS, MECDP synthase))//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.12</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOVALERYL__45__COA__45__FAD__45__RXN" name="Isovaleryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2223_mcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylsuccinyl-CoA dehydrogenase, putative isobutyryl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R342__45__RXN" name="Cobaltochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3440_cobT ) or ( META1_3441_cobS ) or ( META1_1328 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cobaltochelatase (cobT protein)//Cobaltochelatase ) or ( Cobaltochelatase (cobS protein)//Cobaltochelatase ) or ( putative cobaltochelatase, CobN subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 6.6.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CO__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__43__2" stoichiometry="1"/>
      <speciesReference species="CPD__45__688" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__689" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__1__46__2__45__RXN" name="Precorrin-8X methylmutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1326_cobH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-8X methylmutase (Precorrin isomerase) (HBA synthase)//Precorrin-8X methylmutase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 5.4.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__686" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__687" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FADSYN__45__RXN" name="FMN adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0335_ribF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative riboflavin biosynthesis protein ribF [Includes: Riboflavin kinase (Flavokinase); FMN adenylyltransferase (FAD pyrophosphorylase) (FAD synthetase)]//FADSYN-RXN//RIBOFLAVINKIN-RXN//FAD synthetase//Riboflavin kinase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.2</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3170_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxybutyrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5182_hbd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-beta-hydroxybutyrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.30</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__335" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMATE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Glutamate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0204_argJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate N-acetyltransferase/amino-acid acetyltransferase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.35</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYLGLUCOSAMINE__45__4__45__EPIMERASE__45__RXN" name="UDP-N-acetylglucosamine 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5070 ) or ( META1_2016 ) or ( META1_0148 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( Putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPDEPHOS__45__RXN" name="Pyruvate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0140_pyk ) or ( META1_2749_pyk ) or ( META1_2941_pyk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate kinase ) or ( pyruvate kinase ) or ( Pyruvate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.40</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0773_purB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase//AICARSYN-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBDEHYDROG__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0211_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline dehydrogenase PutA//RXN-821 )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__ACETYLHOMOSERINE__45__THIOL__45__LYASE__45__RXN" name="O-acetylhomoserine (thiol)-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2508_metY ) or ( META1_5055_metY ) or ( META1_3547_metY ) or ( META1_3362_metY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase)//O-acetylhomoserine aminocarboxypropyltransferase ) or ( trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase)//O-acetylhomoserine aminocarboxypropyltransferase ) or ( Trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase)//O-acetylhomoserine aminocarboxypropyltransferase ) or ( trans-sulfuration enzyme (O-acetylhomoserine aminocarboxypropyltransferase)//O-acetylhomoserine aminocarboxypropyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.49</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7671" stoichiometry="1"/>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8023" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3670 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phytoene dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7408" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8024" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3670 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phytoene dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7408" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__98" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8645" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0105_serA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-3-phosphoglycerate dehydrogenase//PGLYCDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.2</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXYGLUTARIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLU6PDEHYDROG__45__RXN" name="Glucose-6-phosphate 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1408_zwf ) or ( META1_2490_zwf ) or ( META1_0364_zwf ) or ( META1_1864_zwf )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate 1-dehydrogenase (G6PD)//GLU6PDEHYDROG-RXN ) or ( glucose-6-phosphate 1-dehydrogenase//GLU6PDEHYDROG-RXN ) or ( Glucose-6-phosphate 1-dehydrogenase (G6PD)//GLU6PDEHYDROG-RXN ) or ( Glucose-6-phosphate 1-dehydrogenase (G6PD)//GLU6PDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.49</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEAM__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0417 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA/RNA non-specific endonuclease )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8643" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5136_ttuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating])//Tartrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.93</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__TARTRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__66" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8642" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3354_icd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__99__46__15__45__RXN" name="(1,4)-&amp;alpha;-D-glucan 1-&amp;alpha;-D-glucosylmutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2905 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative malto-oligosyltrehalose synthase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOOLIGOSYLTREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSDECARB__45__RXN" name="Phosphopantothenoylcysteine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4307_coaBC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Coenzyme A biosynthesis bifunctional protein coaBC (DNA/pantothenate metabolism flavoprotein) [Phosphopantothenoylcysteine decarboxylase (PPCDC) (CoaC); Phosphopantothenate-cysteine ligase (Phosphopantothenoylcysteine synthase) (PPC synthetase) (PPCS) (CoaB)]//Phosphopantothenoylcysteine decarboxylase )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.36</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__HALOACID__45__DEHALOGENASE__45__RXN" name="2-haloacid dehalogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3510 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( haloacid dehalogenase, type II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__2__45__Haloacids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__R__45__2__45__Hydroxyacids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Halides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATEKIN__45__RXN" name="Aspartate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0732_ask )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate kinase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UMPKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2119_cmk ) or ( META1_2059_pyrH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine monophosphate (CMP) kinase//CMPKI-RXN ) or ( uridylate kinase )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DARAB5PISOM__45__RXN" name="Arabinose-5-phosphate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3866_kdsD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Arabinose-5-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARABINOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__81" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0009 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative flavin-containing monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2743" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTALDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1961_hisD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional HisD: L-histidinal:NAD+ dehydrogenase ; L-histidinol:NAD+ dehydrogenase//HISTALDEHYD-RXN//HISTOLDEHYD-RXN )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FGAMSYN__45__RXN" name="phosphoribosylformylglycinamidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0010_purL ) or ( META1_0423_yexA ) or ( META1_0424_purQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylformylglycinamide synthetase//FGAMSYN-RXN ) or ( Phosphoribosylformylglycinamidine synthetase PurS ) or ( phosphoribosylformylglycinamidine synthase I )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTPPYPHOSKIN__45__RXN" name="GTP diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3408_relA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP pyrophosphokinase )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__TP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__FORMYLGLUTAMATE__45__DEFORMYLASE__45__RXN" name="N-formylglutamate deformylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3487 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-formylglutamate amidohydrolase (Beta-citryl-L-glutamate hydrolase) )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.68</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__600" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2856 ) or ( META1_1130 ) or ( META2_0017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cytochrome P450 hydroxylase superfamily proteins ) or ( putative cytochrome P450 ) or ( Putative cytochrome P450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_PROPIONYL__45__COA_COF_RXN" name="CO-A_TO_PROPIONYL-COA_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="POLYPHOSPHATE__45__KINASE__45__RXN" name="Polyphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2049_ppk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyphosphate kinase, component of RNA degradosome//POLYPHOSPHATE-KINASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8630" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2856 ) or ( META2_0017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cytochrome P450 hydroxylase superfamily proteins ) or ( Putative cytochrome P450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8631" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2370_cbbA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-bisphosphate aldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__1__46__103__45__RXN" name="Cyclohexyl-isocyanide hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3533_inh ) or ( META1_4818_inh ) or ( META1_0926_inh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isonitrile hydratase, ThiJ/PfpI family protein ) or ( isonitrile hydratase precursor, ThiJ/PfpI family protein ) or ( isonitrile hydratase, ThiJ/PfpI family protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.103</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__CYCLOHEXYLFORMAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYCLOHEXYL__45__ISOCYANIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE__45__OXID__45__RXN" name="L-aspartate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2836 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative L-aspartate oxidase (nadB-like)//L-aspartate oxidase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMINOASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__ATP__45__RXN" name="DNA ligase (ATP)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3448 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ATP-dependent DNA ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_SUC_COF_RXN" name="2-KETOGLUTARATE_TO_SUC_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__3__46__2__46__9__45__RXN" name="Microsomal epoxide hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4213 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alpha/beta hydrolase, putative epoxide hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8984" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8985" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPCARBOX__45__RXN" name="Phosphoenolpyruvate carboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4982 ) or ( META1_1732_ppc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoenolpyruvate carboxylase ) or ( phosphoenolpyruvate carboxylase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.31</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSHTRAN__45__RXN" name="Glutathione transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2313 ) or ( META1_4937 ) or ( META1_2245 ) or ( META1_5215 ) or ( META1_4442 ) or ( META1_3345 ) or ( META1_2388 ) or ( META1_4414 ) or ( META1_2830_maiA ) or ( META1_3210 ) or ( META1_1798 ) or ( META1_5324 ) or ( META1_3680 ) or ( META1_4147 ) or ( META1_2720 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( maleylacetoacetate isomerase (glutathione S-transferase) ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase ) or ( putative glutathione S-transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RX" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HX" stoichiometry="1"/>
      <speciesReference species="__124__S__45__Substituted__45__Glutathione__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0021_nrd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleoside-diphosphate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.4.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxy__45__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5194" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5090_mraW )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosyl-dependent methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Methyl__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5190" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3267 ) or ( META1_3484 ) or ( META1_0817 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative membrane bound lytic murein transglycosylase B, mltB ) or ( putative membrane bound lytic murein transglycosylase B, mltB ) or ( putative membrane bound lytic murein transglycosylase B, mltB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1174" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1176" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1175" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8447" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__AMINO__45__PROPAN__45__2__45__ONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG1P__45__URIDYLTRANS__45__RXN" name="UDP-N-acetylglucosamine pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4544 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glmU-like gene; bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal) )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.23</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__METHYLTHIOADENOSINE__45__PHOSPHORYLASE__45__RXN" name="5&apos;-methylthioadenosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2512 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 5&apos;-methylthioadenosine phosphorylase (mtnP-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__2__46__10__45__RXN" name="UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5086_murF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__209" stoichiometry="1"/>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2856 ) or ( META1_1130 ) or ( META2_0017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cytochrome P450 hydroxylase superfamily proteins ) or ( putative cytochrome P450 ) or ( Putative cytochrome P450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2750" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__9__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1642 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2OG-Fe(II) oxygenase superfamily )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.9</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FLAVANONES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Dihydroflavonols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2856 ) or ( META1_1130 ) or ( META2_0017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cytochrome P450 hydroxylase superfamily proteins ) or ( putative cytochrome P450 ) or ( Putative cytochrome P450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2751" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PORPHOBILSYNTH__45__RXN" name="Porphobilinogen synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4633_hemB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( porphobilinogen synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.24</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8036" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2480 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glycoside hydrolase, family 3, N-terminal and C-terminal domain (bglX-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7417" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7418" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__169" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2856 ) or ( META1_1130 ) or ( META2_0017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cytochrome P450 hydroxylase superfamily proteins ) or ( putative cytochrome P450 ) or ( Putative cytochrome P450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3188" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5184" name="Phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2008_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R344__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1337_cobO ) or ( META1_1433_meaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cob(I)yrinic acid a,c-diamide adenosyltransferase (Cob(I)alamin adenosyltransferase) (Corrinoid adenosyltransferase)//Cob(I)yrinic acid a,c-diamide adenosyltransferase ) or ( cobalamin adenosyltransferase, methylmalonyl-CoA mutase cofactor biosynthesis protein )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__694" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5180" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4452_uppS ) or ( META1_2070_uppS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) ) or ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5182" name="maltodextrin phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2008_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATEORTHOPHOSPHATE__45__DIKINASE__45__RXN" name="Pyruvate,phosphate dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3097_ppdK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyruvate phosphate dikinase (Pyruvate, orthophosphate dikinase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R311__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0687 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amidase )</html:p>
<html:p>SUBSYSTEM: acrylonitrile degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__61" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2856 ) or ( META1_1130 ) or ( META2_0017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cytochrome P450 hydroxylase superfamily proteins ) or ( putative cytochrome P450 ) or ( Putative cytochrome P450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOSE__45__6__45__PHOSPHATE__45__PHOSPHOKETOLASE__45__RXN" name="Fructose-6-phosphate phosphoketolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0387_xfp ) or ( META1_3806_xfp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase ) or ( D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBREDUCT__45__RXN" name="Pyrroline-5-carboxylate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4140_proC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrroline-5-carboxylate reductase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPCARBTRANS__45__RXN" name="Aspartate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3527_pyrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate carbamoyltransferase )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_1021_katG ) or ( META1_2315 ) or ( META1_3421_katA ) or (  ) or ( META1_0179_katA ) or (  ) or ( META1_4617_cat ) or ( META1_0122 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catalase/hydroperoxidase HPI(I)//CATAL-RXN ) or ( putative catalase precursor ) or ( catalase (hydroperoxidase II) ) or ( fragment of putative manganese catalase (C-terminal fragment) ) or ( catalase (hydroperoxidase II) ) or ( fragment of putative manganese catalase (N-terminal fragment) ) or ( Manganese catalase ) or ( putative catalase )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRCARBOXY__45__RXN" name="Phosphoribosylaminoimidazole carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1937_purK ) or ( META1_1936_purE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit ) or ( phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.21</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DALADALALIG__45__RXN" name="D-alanine--D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3151_ddlB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-alanine--D-alanine ligase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8813" name="all-trans-hexaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: heptaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.33</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R322__45__RXN" name="precorrin-6A synthase (deacetylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3613_cobF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-6A synthase [deacetylating] )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.152</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__662" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__675" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="myo-inositol-1-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0140 ) or ( META1_2872 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Myo-inositol-1-phosphate synthase ) or ( inositol-3-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9106" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SOLANESYL__45__PYROPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9610" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXII__45__RXN" name="Hydroxyacylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2476 ) or ( META1_4209 ) or ( META1_3640 ) or ( META1_1207 ) or ( META1_2584 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative hydroxyacylglutathione hydrolase (gloB-like) with metallo-hydrolase/oxidoreductase domain ) or ( putative hydroxyacylglutathione hydrolase, beta-lactamase domain protein ) or ( putative hydroxyacylglutathion hydrolase ) or ( beta-lactamase domain protein, putative hydroxyacylglutathione hydrolase ) or ( beta-lactamase domain protein, putative hydroxyacylglutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PPENTOMUT__45__RXN" name="Phosphopentomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1808_deoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphopentomutase//D-PPENTOMUT-RXN//PPENTOMUT-RXN )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DXS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2079 ) or ( META1_4706_dxs ) or ( META1_1813_dxs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative transketolase (C-terminal domain) ) or ( 1-deoxy-D-xylulose-5-phosphate synthase ) or ( 1-deoxy-D-xylulose 5-phosphate synthase; flavoprotein, thiamin-binding//DXS-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.7</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R170__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2831_ndh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( respiratory NADH dehydrogenase 2; cupric reductase//NADH dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.16.1.-</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CU__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CU__43__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALDEHYDROG__45__RXN" name="3-isopropylmalate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2491_leuB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-isopropylmalate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.85</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2856 ) or ( META2_0017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cytochrome P450 hydroxylase superfamily proteins ) or ( Putative cytochrome P450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3481" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3483" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9939" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4544 ) or ( META1_2899_speG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glmU-like gene; bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal) ) or ( spermidine N1-acetyltransferase//DIAMACTRANS-RXN//SPERMACTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N1__45__ACETYLSPERMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8269" name="Sulfur reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0109 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Polysulphide reductase, NrfD )</html:p>
<html:p>SUBSYSTEM: sulfur reduction II (via polysulfide)</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Polysulfides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="__124__Polysulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEYLACETOACETATE__45__ISOMERASE__45__RXN" name="Maleylacetoacetate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2830_maiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maleylacetoacetate isomerase (glutathione S-transferase) )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METBALT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3060 ) or ( META1_3766 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cystathionine gamma-synthase, PLP-dependent (metB) ) or ( cystathionine gamma-synthase, PLP-dependent )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.48</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3803 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Zn-containing alcohol dehydrogenase (adh) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGENSYN__45__RXN" name="Starch (bacterial glycogen) synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2004_glgA ) or ( META1_1851_glgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen synthase//GLYCOGENSYN-RXN ) or ( glycogen synthase//GLYCOGENSYN-RXN )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.21</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADCLY__45__RXN" name="Aminodeoxychorismate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4282 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative branched-chain amino acid aminotransferase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.38</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5199" name="guanosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3170_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA__45__DECARBOXYLASE__45__RXN" name="Malonyl-CoA decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5180_matA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malonyl-CoA decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CREATININASE__45__RXN" name="Creatininase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2123 ) or ( META1_4099 ) or ( META1_1638 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( creatininase (creatine amidohydrolase) ) or ( Creatininase ) or ( putative creatininase (creatine amidohydrolase) )</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CREATININE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CREATINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__25__45__RXN" name="Triphosphoribosyl-dephospho-CoA synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0028_mdcB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2&apos;-(5&apos;&apos;-triphosphoribosyl)-3&apos;-dephosphocoenzyme-A synthase )</html:p>
<html:p>SUBSYSTEM: 2&apos;-(5&apos;-phosphoribosyl)-3&apos;-dephospho-CoA biosynthesis II (malonate decarboxylase)</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.25</html:p>
<html:p>SIDE: ADENINE</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="_2__45__5__45__TRIPHOSPHORIBOSYL__45__3__45__DEPHOSPHO__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP cyclohydrolase I" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2264_folE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP cyclohydrolase I )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__170" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2856 ) or ( META2_0017 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cytochrome P450 hydroxylase superfamily proteins ) or ( Putative cytochrome P450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3188" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2749" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__60__45__RXN" name="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3018_ispDF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IspD/IspF bifunctional enzyme (2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase (MEP cytidylyltransferase, MCT); 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECPS, MECDP synthase))//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.60</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__77__45__RXN" name="N-carbamoyl-D-amino acid hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3490 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.77</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Carbamoyl__45__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMSUCTRAN__45__RXN" name="Homoserine O-succinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5056 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative homoserine O-succinyltransferase (metA) )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.46</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPCARBOXYKIN__45__RXN" name="Phosphoenolpyruvate carboxykinase (ATP)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1533_pck )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoenolpyruvate carboxykinase//PEPCARBOXYKIN-RXN )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.49</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOASYN__45__RXN" name="long-chain-fatty-acid--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3910_fadD ) or ( META1_0239 ) or ( META2_0014 ) or ( META1_2130 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)//ACYLCOASYN-RXN ) or ( putative Long-chain acyl-CoA synthetase ) or ( putative fatty-acid--CoA ligase (Acyl-CoA synthetase) ) or ( putative acyl-coenzyme A synthetase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUTP__45__PYROP__45__RXN" name="dUTP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1415_dut )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyuridine 5&apos;-triphosphate nucleotidohydrolase//DUTP-PYROP-RXN )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.23</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOLACT__45__RXN" name="Gluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0437_gnl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gluconolactonase (D-glucono-delta-lactone lactonohydrolase)//Gluconolactonase )</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMARYLACETOACETASE__45__RXN" name="Fumarylacetoacetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2128 ) or ( META1_3706 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Fumarylacetoacetate (FAA) hydrolase family ) or ( putative Fumarylacetoacetate (FAA) hydrolase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINASE__45__RXN" name="Adenosylhomocysteinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4876_ahcY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosyl L-homocysteine hydrolase )</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>PROTEIN_CLASS: 3.3.1.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2661" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3392_mutY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( A/G-specific adenine glycosylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__With__45__G__45__A__45__Mismatch__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__DNA__45__With__45__Mismatched__45__Adenine__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNB__45__RXN" name="asparagine synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5325 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative asparagine synthase, glutamine-hydrolyzing )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.4</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__8__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0556_gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase (NAD+)//GLYC3PDEHYDROGBIOSYN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__METHOXY__45__BENZOQ__45__METH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4311_ubiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ubiquinone/menaquinone biosynthesis methyltransferase ubiE )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHOXY__45__BENZOQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLSEROTONIN__45__O__45__METHYLTRANSFERASE__45__RXN" name="Acetylserotonin O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2925_crtF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyneurosporene methyltransferase CrtF )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.4</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__SEROTONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__5__45__METHOXY__45__TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9912" name="Salicylate 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2195 ) or ( META1_0388 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative salicylate hydroxylase, Salicylate 1-monooxygenase, nahG//Salicylate 1-monooxygenase ) or ( Salicylate hydroxylase (Salicylate 1-monooxygenase)//Salicylate 1-monooxygenase )</html:p>
<html:p>SUBSYSTEM: chlorosalicylate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10576" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9152" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__821" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0211_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline dehydrogenase PutA//RXN-821 )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA_TO_CO__45__A_COF_RXN" name="ACETYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0329_ftfL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formate-tetrahydrofolate ligase (formyltetrahydrofolate synthetase) (FHS) (FTHFS) )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9914" name="Salicylate 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2195 ) or ( META1_0388 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative salicylate hydroxylase, Salicylate 1-monooxygenase, nahG//Salicylate 1-monooxygenase ) or ( Salicylate hydroxylase (Salicylate 1-monooxygenase)//Salicylate 1-monooxygenase )</html:p>
<html:p>SUBSYSTEM: chlorosalicylate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10663" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9152" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1729_fch )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methenyl tetrahydrofolate cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5727" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOKIN__45__RXN" name="Glucokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4840 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glucokinase (Glucose kinase)//Glucokinase ) or ( Glucokinase (Glucose kinase) (fragment)//Glucokinase )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: trehalose degradation IV</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="ribose-phosphate diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4249_prs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylpyrophosphate synthetase )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENINE__45__DEAMINASE__45__RXN" name="adenine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3660_ade )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adenine deaminase (Adenase) (Adenine aminase)//ADENINE-DEAMINASE-RXN//Adenine deaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1815 ) or ( META1_3220_crtB ) or ( META1_1816 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phytoene synthase ) or ( phytoene synthase ) or ( putative phytoene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.32</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__464" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTOENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8001" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1961_hisD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional HisD: L-histidinal:NAD+ dehydrogenase ; L-histidinol:NAD+ dehydrogenase//HISTALDEHYD-RXN//HISTOLDEHYD-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLESTERASE__45__RXN" name="Arylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4381 ) or ( META1_3295 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acyl-CoA thioesterase precursor (tesA-like) ) or ( arylesterase (alpha/beta hydrolase fold), putative haloperoxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phenyl__45__Acetates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9139" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9649" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9138" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9610" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAMKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2863_pdxY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal kinase 2/pyridoxine kinase//PYRIDOXKIN-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLORIDE__45__PEROXIDASE__45__RXN" name="Chloride peroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3295 ) or ( META1_3884 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylesterase (alpha/beta hydrolase fold), putative haloperoxidase ) or ( non-heme haloperoxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.10</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CL__45__" stoichiometry="2"/>
      <speciesReference species="RH" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Chlorides__124__" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1863_gnd ) or ( META1_5283_gnd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase//6PGLUCONDEHYDROG-RXN ) or ( 6-phosphogluconate dehydrogenase//6PGLUCONDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCLOHEXADIENYL__45__DEHYDROGENASE__45__RXN" name="Cyclohexadienyl dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1485 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cyclohexadienyl dehydrogenase (tyrC-like) )</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.43</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__659" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOACYLCOATHIOL__45__RXN" name="Acetyl-CoA C-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3455 ) or ( META1_3700_phaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-ketoacyl-CoA thiolase (Fatty oxidation complex beta subunit) (Beta-ketothiolase) (Acetyl-CoA acyltransferase) (fadA-like) ) or ( beta-ketothiolase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.16</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__KINASE__45__RXN" name="shikimate-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0462 ) or ( META1_2101 ) or ( META1_1535 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Shikimate kinase//Shikimate kinase ) or ( putative shikimate kinase with helix-turn-helix domain ) or ( bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.71</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3541" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1911 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multicopper oxidase, putative manganese-oxidizing multicopper oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__318" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2079 ) or ( META1_4949_tkt ) or ( META1_1861_tkt ) or ( META1_2078 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative transketolase (C-terminal domain) ) or ( transketolase ) or ( transketolase ) or ( putative transketolase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACECOATRANS__45__RXN" name="Acetate CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3125_atoA ) or ( META1_3124_atoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA:acetoacetyl-CoA transferase, beta subunit ) or ( acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__KIN__45__RXN" name="NAD(+) kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0369_ppnK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative inorganic polyphosphate/ATP-NAD kinase (Poly(P)/ATP NAD kinase) )</html:p>
<html:p>SUBSYSTEM: NAD phosphorylation and dephosphorylation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.23</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Quinones__124___TO___124__Reduced__45__Quinones__124___COF_RXN" name="|Quinones|_TO_|Reduced-Quinones|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Reduced__45__Quinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__TYROSINE__45__PHOSPHATASE__45__RXN" name="Protein-tyrosine-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1958 ) or ( META1_4929 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphotyrosine protein phosphatase ) or ( phosphotyrosine protein phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.48</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALGLDAPAALIG__45__RXN" name="UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5086_murF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C1" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATE__45__1__45__EPIMERASE__45__RXN" name="Glucose-6 phosphate 1-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: sucrose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINESYN__45__RXN" name="Spermidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2977 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative spermidine synthase ) or ( conserved hypothetical protein; putative spermidine synthase (fragment) )</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9157" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5308 ) or ( META1_1682_ggt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative gamma-glutamyltranspeptidase ) or ( gamma-glutamyltranspeptidase//GAMMA-GLUTAMYLTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9699" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9700" stoichiometry="1"/>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__OCTAPRENYLTRANSTRANSFERASE__45__RXN" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SOLANESYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TARTRATE__45__DEHYDROGENASE__45__RXN" name="Tartrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5136_ttuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating])//Tartrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.93</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__66" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMAMIDASE__45__RXN" name="Formamidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3601_fmdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formamidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.49</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9348" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9958" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__10" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9347" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9957" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9346" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9956" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9345" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-7 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9955" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9717" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2043" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1169 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative cellulase, endoglucanase (celC) )</html:p>
<html:p>SUBSYSTEM: cellulose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFOCYS__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1278_cysK ) or ( META1_0751_cysK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cysteine synthase ) or ( subunit of cysteine synthase A and O-acetylserine sulfhydrolase A, PLP-dependent enzyme//ACSERLY-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.47</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFO__45__CYSTEINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERKIN__45__RXN" name="Homoserine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2714_thrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoserine kinase )</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.39</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0175_ilvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ketol-acid reductoisomerase )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I (from threonine)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__AMIDINOTRANSFERASE__45__RXN" name="Glycine amidinotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3682_gatm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glycine amidinotransferase (L-arginine:glycine amidinotransferase)//Glycine amidinotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.4.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="GUANIDOACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9364" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9650" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9972" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICONUCADENYLYLTRAN__45__RXN" name="Nicotinate-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3073_nadD ) or ( META1_2837_nadC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate-nucleotide adenylyltransferase (Deamido-NAD(+) pyrophosphorylase) (Deamido-NAD(+) diphosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase)//NICONUCADENYLYLTRAN-RXN ) or ( nicotinate-mononucleotide pyrophosphorylase//QUINOPRIBOTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__133__45__RXN" name="Precorrin-4 C11-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0804_cobM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-4 C(11)-methyltransferase (Precorrin-3 methylase)//Precorrin-4 C(11)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.133</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYRIBONUCSYN__45__RXN" name="Phosphoribosylamine--glycine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4244_purD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide synthetase (GAR synthetase)//GLYRIBONUCSYN-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFATE__45__ADENYLYLTRANS__45__RXN" name="Sulfate adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2229_cysD ) or ( META1_2228_cysN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Sulfate adenylyltransferase subunit 2 (Sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit)//SULFATE-ADENYLYLTRANS-RXN//Sulfate adenylyltransferase ) or ( ATP-sulfurylase, subunit 1 (ATP:sulfate adenylyltransferase)//SULFATE-ADENYLYLTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: sulfite oxidation III</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.4</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPMANNACADEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5069 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__MANNACA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OXALODECARB__45__RXN" name="Oxaloacetate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1985_eda )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase//4OH2OXOGLUTARALDOL-RXN//KDPGALDOL-RXN//OXALODECARB-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9583" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2079 ) or ( META1_4949_tkt ) or ( META1_1861_tkt ) or ( META1_2078 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative transketolase (C-terminal domain) ) or ( transketolase ) or ( transketolase ) or ( putative transketolase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="CPD__45__10226" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10227" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLCNACEPIM__45__RXN" name="UDP-N-acetylglucosamine 2-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine 2-epimerase-like protein (fragment)//UDP-N-acetylglucosamine 2-epimerase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9952" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1863_gnd ) or ( META1_5283_gnd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase//6PGLUCONDEHYDROG-RXN ) or ( 6-phosphogluconate dehydrogenase//6PGLUCONDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9951" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3354_icd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRIBFAICARPISOM__45__RXN" name="N-(5&apos;-phospho-D-ribosylformimino)-5-amino-1-(5&apos;&apos;-phosphoribosyl)-4- imidazole carboxamide isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2518_hisA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-(5&apos;-phospho-L-ribosyl-formimino)-5-amino-1-(5&apos;-phosphoribosyl)-4-imidazolecarboxamide isomerase//PRIBFAICARPISOM-RXN )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3082_pgsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylglycerophosphate synthetase//PHOSPHAGLYPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis I (plastid)</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.5</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLPROLYL__45__ISOMERASE__45__RXN" name="Peptidylprolyl isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5095_fbp ) or ( META1_5021_ppiB ) or ( META2_0770 ) or ( META1_5019 ) or ( META1_2418_tig )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptidyl-prolyl cis-trans isomerase (Rotamase) ) or ( peptidyl-prolyl cis-trans isomerase B (rotamase B)(PPIase B)//PEPTIDYLPROLYL-ISOMERASE-RXN ) or ( putative PpiC-type peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase (rotamase) precursor ) or ( Trigger factor (TF) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8625" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA_TO_CO__45__A_COF_RXN" name="ACYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__NITROPROPANE__45__DIOXYGENASE__45__RXN" name="2-nitropropane dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5191_2-npdl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-nitropropane dioxygenase, (nitroalkane oxidase) (2- NPD)//2-nitropropane dioxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.32</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__244" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="2"/>
      <speciesReference species="ACETONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__81__45__RXN" name="Threonine-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5176_cobC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Threonine-phosphate decarboxylase (L-threonine-O-3- phosphate decarboxylase)//Threonine-phosphate decarboxylase )</html:p>
<html:p>SUBSYSTEM: aminopropanol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.81</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__THREONINE__45__O__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__1__45__AMINOPROPAN__45__2__45__YL__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0290 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Methyltransferase FkbM )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10014" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9943" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4544 ) or ( META1_2899_speG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glmU-like gene; bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal) ) or ( spermidine N1-acetyltransferase//DIAMACTRANS-RXN//SPERMACTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__568" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__17__45__RXN" name="Phosphatidylethanolamine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4487 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphatidylethanolamine-N-methyltransferase (pmtA) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.17</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__405" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__130__45__RXN" name="Precorrin-2 C20-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1325_cobI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-2 C(20)-methyltransferase (S-adenosyl-L- methionine--precorrin-2 methyltransferase) (SP2MT)//Precorrin-2 C(20)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.130</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__642" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__2__46__3__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3452 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__3__45__HYDROXYBUTANOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1818_shc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene-hopene-cyclase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOPAN__45__22__45__OL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GART__45__RXN" name="Phosphoribosylglycinamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2044_purN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylglycinamide formyltransferase 1//GART-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.2</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOSEPHOSPHO__45__RXN" name="transport of fructose by PTS" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1020 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative PTS system subfamily mannose/fructose-specific IIA component )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU1P" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__113__45__RXN" name="Site-specific DNA-methyltransferase (cytosine-N4-specific)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0396 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative DNA methylase N-4/N-6 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.113</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__Cytosine__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__DNA__45__N4__45__Methylcytosine__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__8__45__RXN" name="Dimethylaniline monooxygenase (N-oxide forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0009 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative flavin-containing monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NN__45__DIMETHYLANILINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NN__45__DIMETHYLANILINE__45__N__45__OXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAPOXNPHOSPHN__45__RXN" name="Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2367_gapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glyceraldehyde-3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD_TO_FADH2_COF_RXN" name="FAD_TO_FADH2_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FADH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9770" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3920 ) or ( META1_3561_ssuD ) or ( META1_0947 ) or ( META1_3637_ssuD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Alkanesulfonate monooxygenase ) or ( Alkanesulfonate monooxygenase ) or ( putative alkanesulfonate monooxygenase ) or ( alkanesulfonate monooxygenase )</html:p>
<html:p>SUBSYSTEM: dimethylsulfide degradation II (oxidation)</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.5</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FMN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FMNH2</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3746" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1937_purK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase = AIR carboxylase, CO(2)-fixing subunit )</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.18</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__181" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__743" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1936_purE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole carboxylase = AIR carboxylase, catalytic subunit )</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__181" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9772" name="L-aspartate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2836 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative L-aspartate oxidase (nadB-like)//L-aspartate oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="IMINOASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5603" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4535_mxaI ) or ( META1_4538_mxaF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Methanol dehydrogenase subunit 2 precursor (MDH small beta subunit) ) or ( Methanol dehydrogenase subunit 1 precursor (MDH large alpha subunit) (MEDH) )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.8</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__341" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__274__45__RXN" name="2,5-didehydrogluconate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2002_dkgA ) or ( META2_0870_dkgA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,5-diketo-D-gluconate reductase A//1.1.1.274-RXN//RXN0-1941 ) or ( 2,5-diketo-D-gluconate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.274</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_25__45__DIDEHYDRO__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHEAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1486_hisC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinol-phosphate aminotransferase//HISTAMINOTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3503_argH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERPHOSPHA__45__RXN" name="Phosphoserine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2848 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoserine phosphatase (serB-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phosphoserines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Serines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATEMUT__45__RXN" name="Chorismate mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0478 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative chorismate mutase )</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis III</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4OHBENZOATE__45__OCTAPRENYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0666_ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( p-hydroxybenzoate octaprenyltransferase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.39</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALADENOSYLTRANS__45__RXN" name="Cob(I)alamin adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1337_cobO ) or ( META1_1433_meaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cob(I)yrinic acid a,c-diamide adenosyltransferase (Cob(I)alamin adenosyltransferase) (Corrinoid adenosyltransferase)//Cob(I)yrinic acid a,c-diamide adenosyltransferase ) or ( cobalamin adenosyltransferase, methylmalonyl-CoA mutase cofactor biosynthesis protein )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COB__45__I__45__ALAMIN" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Succinate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4598 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate-semialdehyde dehydrogenase I, NADP-dependent (gabD-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.24</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATESYNTH__45__RXN" name="dihydrofolate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4888_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional folylpolyglutamate synthase and dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16ALDOLASE__45__RXN" name="Fructose-bisphosphate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2370_cbbA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-bisphosphate aldolase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7607" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4626_surE ) or ( META1_2085 ) or ( META1_2566_soxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase) ) or ( hypothetical protein, putative 5&apos;-nucleotidase domain//5&apos;-nucleotidase ) or ( sulfur/thiosulfate oxidation protein precursor (tat pathway signal) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOSE__45__OXIDASE__45__RXN" name="Galactose oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0037 ) or ( META1_0991 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative galactose oxidase (modular protein) ) or ( putative Galactose oxidase//Galactose oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__155" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7609" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4626_surE ) or ( META1_2085 ) or ( META1_2566_soxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase) ) or ( hypothetical protein, putative 5&apos;-nucleotidase domain//5&apos;-nucleotidase ) or ( sulfur/thiosulfate oxidation protein precursor (tat pathway signal) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9868" name="Carboxymethylenebutenolidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1735 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative carboxymethylenebutenolidase precursor (dienelactone hydrolase) (tat pathway signal) )</html:p>
<html:p>SUBSYSTEM: 3-chlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.45</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10608" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__PHYT__45__RXN" name="6-phytase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0512 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Prepilin peptidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MI__45__PENTAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1826" name="starch phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2008_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__1439" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4841 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative trehalose-6-phosphate phosphatase (otsB) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__774" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1354" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMACTRAN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4544 ) or ( META1_2899_speG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glmU-like gene; bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal) ) or ( spermidine N1-acetyltransferase//DIAMACTRANS-RXN//SPERMACTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLSPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1828" name="disproportionating enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2905 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative malto-oligosyltrehalose synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2294_argG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate synthase (citrulline-aspartate ligase)//ARGSUCCINSYN-RXN )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXBUTYRYL__45__COA__45__DEHYDRATASE__45__RXN" name="3-hydroxybutyryl-CoA dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3675_croR ) or ( META1_5098_croA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( crotonase ) or ( 3-hydroxybutyryl-CoA dehydratase )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate I</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.55</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__DEHYDRATASE__45__RXN" name="3-dehydroquinate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0864_aroQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-dehydroquinate dehydratase (3-dehydroquinase) (Type II DHQase)//3-dehydroquinate dehydratase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__1437" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4841 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative trehalose-6-phosphate phosphatase (otsB) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__772" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1346" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__1438" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4841 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative trehalose-6-phosphate phosphatase (otsB) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__773" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1353" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__1435" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4841 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative trehalose-6-phosphate phosphatase (otsB) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__768" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1344" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__1436" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4841 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative trehalose-6-phosphate phosphatase (otsB) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__771" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1345" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTOX__45__RXN" name="Dihydroorotate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2095_pyrD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydro-orotate oxidase, FMN-linked//DIHYDROOROTOX-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALAMINSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0681_cobV )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cobalamin synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.26</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__RIBAZOLE" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7614" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5044 ) or ( META1_5057 ) or ( META1_4133 ) or ( META1_1639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative o-succinylbenzoate--CoA ligase//o-succinylbenzoate--CoA ligase ) or ( putative fatty acid metabolism AMP-binding protein ) or ( putative non-ribosomal peptide synthetase, putative acyl-CoA ligase for activation during siderophore synthesis ) or ( putative Long-chain-fatty-acid--CoA ligase (Long-chain acyl-CoA synthetase) (Acyl-CoA synthetase) (putative fadD) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="O__45__SUCCINYLBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6972" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHBUTYRYL__45__COA__45__EPIM__45__RXN" name="3-hydroxybutyryl-CoA epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3452 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSALDOL__45__RXN" name="Transaldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4950 ) or ( META1_1862 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Transaldolase Phosphoglucose isomerase//Transaldolase ) or ( putative Transaldolase Phosphoglucose isomerase//Transaldolase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GENTAMICIN__45__3__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Gentamicin 3&apos;-N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4325 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gentamicin 3&apos;-N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.60</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GENTAMICIN__45__C" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N3__45__ACETYLGENTAMICIN__45__C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPDEHYDRHAMEPIM__45__RXN" name="dTDP-4-dehydrorhamnose 3,5-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4042_rfbC ) or ( META1_0615_rfbC ) or ( META1_2394_rfbC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-4-dehydrorhamnose 3,5-epimerase ) or ( dTDP-4-dehydrorhamnose 3,5-epimerase ) or ( dTDP-4-dehydrorhamnose 3,5-epimerase )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCSEMIALDDEHYDROG__45__RXN" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4598 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate-semialdehyde dehydrogenase I, NADP-dependent (gabD-like) )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPH_TO_NADP_COF_RXN" name="NADPH_TO_NADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4888_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional folylpolyglutamate synthase and dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINE__45__DEHYDROGENASE__45__RXN" name="Amine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2770_mauB ) or ( META1_2773_mauA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Methylamine dehydrogenase large subunit precursor (MADH) ) or ( Methylamine dehydrogenase small subunit precursor (MADH) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PABSYNMULTI__45__RXN" name="synthesis of p-aminobenzoic acid" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4284_pabB ) or ( META1_4283_pabA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( para-aminobenzoate synthase component I (ADC synthase)//PABASYN-RXN ) or ( aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex//PABASYN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__77__45__RXN" name="Protein-L-isoaspartate(D-aspartate) O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4625_pcm ) or ( META1_5146 ) or ( META1_4657_pcm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-isoaspartate protein carboxylmethyltransferase type II//2.1.1.77-RXN ) or ( putative protein-L-isoaspartate O-methyltransferase ) or ( L-isoaspartate protein carboxylmethyltransferase type II//2.1.1.77-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.77</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOASPARTATES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DARABALDOL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5229_fucA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-fuculose-1-phosphate aldolase//FUCPALDOL-RXN )</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__RIBULOSE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CELLULOSE__45__SYNTHASE__45__UDP__45__FORMING__45__RXN" name="Cellulose synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0898 ) or ( META1_0940 ) or ( META1_1167_celA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Cellulose synthase catalytic subunit [UDP-forming] ) or ( putative Cellulose synthase (UDP-forming) ) or ( Cellulose synthase (UDP-forming) )</html:p>
<html:p>SUBSYSTEM: cellulose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.12</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__4__46__3__46__19__45__RXN" name="Glycine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0430_thiO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAMPYR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0485_serC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3OH__45__4P__45__OH__45__ALPHA__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDO__45__8PSYNTH__45__RXN" name="2-dehydro-3-deoxyphosphooctonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2981_kdsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-8-phosphooctulonate synthase )</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.55</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARABINOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO__45__8P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCPALDOL__45__RXN" name="L-fuculose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5229_fucA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-fuculose-1-phosphate aldolase//FUCPALDOL-RXN )</html:p>
<html:p>SUBSYSTEM: lactate biosynthesis</html:p>
<html:p>SUBSYSTEM: fucose degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FUCULOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTALD" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM2__45__RXN" name="Cytidine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3171_cdd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase (cytidine aminohydrolase) )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP_TO_GTP_COF_RXN" name="GDP_TO_GTP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4282 ) or ( META1_5053 ) or ( META1_2707 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative branched-chain amino acid aminotransferase ) or ( putative branched-chain amino acid aminotransferase ) or ( putative branched-chain amino acid transferase (ilvE-like) )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I (from threonine)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREDEHYD__45__RXN" name="Threonine dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3241_ilvA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine deaminase//THREDEHYD-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I (from threonine)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.19</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO___124__Fatty__45__Acyl__45__CoA__124___COF_RXN" name="CO-A_TO_|Fatty-Acyl-CoA|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHUROPORDEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3434_cysG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Siroheme synthase//DIMETHUROPORDEHYDROG-RXN//RXN-8675//SIROHEME-FERROCHELAT-RXN//UROPORIIIMETHYLTRANSA-RXN )</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.76</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTPDECARB__45__RXN" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1411_pyrF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( orotidine 5&apos;-phosphate decarboxylase//OROTPDECARB-RXN )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.23</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2023" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4486_trmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__THIOURIDINE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSPSYN__45__RXN" name="glutathionylspermidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_1306 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative Glutathionylspermidine synthase family protein )</html:p>
<html:p>SUBSYSTEM: glutathionylspermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONYLSPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2022" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1455_poxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( poxB; pyruvate dehydrogenase/oxidase: FAD- and thiamin PPi-binding//PYRUVOXID-RXN )</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROT__45__RXN" name="Dihydroorotase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3528_pyrC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dihydroorotase-like protein )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROG__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5249_glpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sn-glycerol-3-phosphate dehydrogenase FAD/NAD(P)-binding (aerobic)//GLYC3PDEHYDROG-RXN//RXN0-5258 )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.5.3</html:p>
<html:p>SIDE: UBIQUINOL__45__8</html:p>
<html:p>SIDE: UBIQUINONE__45__8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2602" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4436_mutM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (DNA-(apurinic or apyrimidinic site) lyase mutM) (AP lyase mutM)//RXN0-2602 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.23</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Damaged__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__AP__45__Site__45__Created__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2604" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4550_recG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA helicase, ATP-dependent resolution of Holliday junctions, branch migration )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__with__45__Holiday__45__Junctions__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__DNA__45__Segments__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLPHOSPHATASE__45__RXN" name="Acylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3206_acyP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acylphosphatase (Acylphosphate phosphohydrolase)//Acylphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acyl__45__Phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__901" name="Xanthine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3016 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxidoreductase, molybdopterin-binding subunit )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2606" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1532_recR ) or ( META1_0821_recO ) or ( META1_0003_recF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( recombination protein recR ) or ( DNA repair protein RecO ) or ( putative RecF protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Unstable__45__RecA__45__Filament__45__DNA__45__Complex__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Stabilized__45__RecA__45__Filament__45__DNA__45__Complex__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1241" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0728_prmC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein-(glutamine-N5) methyltransferase, release factor-specific )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N5__45__METHYLGLUTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__2__46__8__45__RXN" name="Indole-3-glycerol-phosphate lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4890_trpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase alpha subunit//TRYPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7082" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2480 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glycoside hydrolase, family 3, N-terminal and C-terminal domain (bglX-like) )</html:p>
<html:p>SUBSYSTEM: DIMBOA-glucoside degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6562" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__6366" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__54__45__RXN" name="Precorrin-6X reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5173_cobK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-6A reductase (Precorrin-6X reductase)//Precorrin-6A reductase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.54</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__675" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__679" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__SYN__45__RXN" name="glutathione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0712_gshB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione synthetase//GLUTATHIONE-SYN-RXN )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__NUCLEOTID__45__RXN" name="3&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4626_surE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7648" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1642 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2OG-Fe(II) oxygenase superfamily )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.9</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6991" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6992" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEHYDROG__45__RXN" name="Homoserine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1941_hom )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Homoserine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__39__45__RXN" name="Malate dehydrogenase (decarboxylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0594_dme )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD-dependent malic enzyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.39</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALA__45__GLU__45__LIG__45__RXN" name="UDP-N-acetylmuramoylalanine--D-glutamate ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5084_murD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanine--D-glutamate ligase//UDP-NACMURALA-GLU-LIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__ACETYLMURAMOYL__45__ALA" stoichiometry="1"/>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHAMLY__45__RXN" name="Ethanolamine ammonia-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1926_eutB ) or ( META1_1927 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ethanolamine ammonia-lyase, heavy chain//ETHAMLY-RXN ) or ( putative ethanolamine ammonia-lyase light chain (eutC-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KANAMYCIN__45__KINASE__45__RXN" name="Kanamycin kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1683 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aminoglycoside phosphotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.95</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Kanamycins__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Kanamycin__45__3__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATESYN__45__RXN" name="Thymidylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2853_thyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate synthetase//THYMIDYLATESYN-RXN )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.45</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: DIHYDROFOLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7660" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: phytyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7003" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOESTER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5221_ybgC ) or ( META1_2544_yciA ) or ( META1_2086_tesB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase ) or ( acyl-CoA thioester hydrolase ) or ( acyl-CoA thioesterase II )</html:p>
<html:p>SUBSYSTEM: acyl-CoA hydrolysis</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Saturated__45__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__280" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3920 ) or ( META1_3561_ssuD ) or ( META1_0947 ) or ( META1_3637_ssuD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Alkanesulfonate monooxygenase ) or ( Alkanesulfonate monooxygenase ) or ( putative alkanesulfonate monooxygenase ) or ( alkanesulfonate monooxygenase )</html:p>
<html:p>SUBSYSTEM: two-component alkanesulfonate monooxygenase</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.5</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alkanesulfonates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7657" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3803 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Zn-containing alcohol dehydrogenase (adh) )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7000" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOBUTANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7658" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: phytyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7002" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1990_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7659" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: phytyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7002" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7003" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DADP_TO_DATP_COF_RXN" name="DADP_TO_DATP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="DADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2625" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4660_mutL ) or ( META1_4678_mutS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA mismatch repair protein mutL ) or ( DNA mismatch repair protein mutS )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8199" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8200" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__99__46__16__45__RXN" name="Maltose &amp;alpha;-D-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2908 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative maltose alpha-D-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHLBXANAU__45__RXN" name="2-haloacid dehalogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3510 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( haloacid dehalogenase, type II )</html:p>
<html:p>SUBSYSTEM: 1,2-dichloroethane degradation</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROACETIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__SYNTHASE__45__RXN" name="3-dehydroquinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1535 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional shikimate kinase (N-terminal) / dehydroquinate synthase (C-terminal) enzyme )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2622" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2959_recJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative single-strand DNA-specific exonuclease RecJ )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8180" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8181" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__2__45__PHOSPHATASE__45__RXN" name="Glycerol-2-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0426_suhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol monophosphatase//RXN0-5408 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__536" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2621" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3083_uvrC ) or ( META1_4267_uvrA ) or ( META1_4445_uvrB ) or ( META1_0214_uvrD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA exisiton repair enzyme together with UvrAB ) or ( DNA excision repair enzyme subunit, with UvrBC ) or ( UvrABC system protein B (UvrB protein) (Excinuclease ABC subunit B) ) or ( DNA-dependent ATPase I and helicase II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.25-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8180" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8534" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2624" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0737_ruvC ) or ( META1_0739_ruvA ) or ( META1_5225_ruvB ) or ( META2_0995_ruvB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RuvC; Holliday junction nuclease//RXN0-2624 ) or ( Holliday junction ATP-dependent DNA helicase ruvA ) or ( Holliday junction ATP-dependent DNA helicase//RXN0-2624 ) or ( ATP-dependent DNA helicase, component of RuvABC resolvasome//RXN0-2624 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.22.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__Combined__45__With__45__Exogenous__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Resolution__45__of__45__Recombinational__45__Junction__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1404" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_1120 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nitrilase )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLEYL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRTRANS__45__RXN" name="Anthranilate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5120_trpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anthranilate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2081" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3433_nasA ) or ( META1_1806 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrate reductase, large subunit ) or ( putative molybdopterin oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TEICHOICSYN2__45__RXN" name="N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-&amp;beta;-D- mannosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4520 ) or ( META1_5072 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative N-acetylmannosaminyltransferase tagA ) or ( putative glycosyl transferase, WecB/TagA/CpsF family )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.187</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__D__45__GLUCOSAMINYLDIPHOSPHO__45__UNDECAPRE" stoichiometry="1"/>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__ETCETERA__45__GLUCOSAMINYLDIPHOSPHOUND" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7666" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: chlorophyll a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7006" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLOROPHYLL__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCINYLBENZOATE__45__COA__45__LIG__45__RXN" name="O-succinylbenzoate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5044 ) or ( META1_5057 ) or ( META1_4133 ) or ( META1_1639 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative o-succinylbenzoate--CoA ligase//o-succinylbenzoate--CoA ligase ) or ( putative fatty acid metabolism AMP-binding protein ) or ( putative non-ribosomal peptide synthetase, putative acyl-CoA ligase for activation during siderophore synthesis ) or ( putative Long-chain-fatty-acid--CoA ligase (Long-chain acyl-CoA synthetase) (Acyl-CoA synthetase) (putative fadD) )</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.26</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__SUCCINYLBENZOATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6972" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7669" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2910_glgB ) or ( META1_1850_glgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,4-alpha-glucan branching enzyme ) or ( 1,4-alpha-glucan branching enzyme, glycogen synthesis//GLYCOGEN-BRANCH-RXN//1,4-alpha-glucan branching enzyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7664" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: chlorophyll a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7005" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7004" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7665" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: chlorophyll a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7004" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7006" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTSEMIALDEHYDROG__45__RXN" name="Glutamate-5-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3072_proA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gamma-glutamyl phosphate reductase (GPR) (Glutamate-5- semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase)//GLUTSEMIALDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1461" name="Coproporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0498_hemF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Coproporphyrinogen III oxidase, aerobic (Coproporphyrinogenase) (Coprogen oxidase)//RXN0-1461 )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__2__46__10__45__RXN" name="Phosphoglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5297_glmM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglucosamine mutase )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSAMINE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSMANMUT__45__RXN" name="Phosphomannomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4513 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Phosphomannomutase/phosphoglucomutase (AlgC)//Phosphomannomutase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMIDASE__45__RXN" name="Amidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0687 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Monocarboxylic__45__Acid__45__Amides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Monocarboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__262" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5015_mobA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( molybdopterin-guanine dinucleotide biosynthesis protein A )</html:p>
<html:p>SUBSYSTEM: molybdopterin guanine dinucleotide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="CPD__45__8123" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__582" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__34" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0363_rocF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase (arginine amidinase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7682" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3016 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxidoreductase, molybdopterin-binding subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPRIBOSYLTRAN__45__RXN" name="Adenine phosphoribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0425_apt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.7</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPRIBOSYLTRAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3063_hpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hypoxanthine phosphoribosyl transferase//GUANPRIBOSYLTRAN-RXN//HYPOXANPRIBOSYLTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DMBPPRIBOSYLTRANS__45__RXN" name="Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0682_cobU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (N(1)-alpha-phosphoribosyltransferase)//Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.21</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NIACINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
      <speciesReference species="DIMETHYLBENZIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__RIBAZOLE__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5323_ilvH ) or ( META1_5051 ) or ( META1_5321_ilvI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetolactate synthase III, small subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN ) or ( putative acetolactate synthase large subunit (ilvG) ) or ( acetolactate synthase III, large subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I (from threonine)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALYL__45__COA__45__LYASE__45__RXN" name="Malyl-CoA lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1733_mcl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malyl-CoA lyase/beta-methylmalyl-CoA lyase )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.24</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__208" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNN__45__404" name="indole acetamide hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0687 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amidase )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis IV</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis VI (via indole-3-acetamide)</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__237" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHEBDEAMID__45__RXN" name="Protein-glutamine glutaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1424_cheB ) or ( META1_3042_cheB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Chemotaxis response regulator protein-glutamate methylesterase//MCPMETEST-RXN ) or ( Chemotaxis response regulator protein-glutamate methylesterase//MCPMETEST-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.44</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__L__45__glutamine__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Glutamates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Donor__45__H2__124___TO___124__Acceptor__124___COF_RXN" name="|Donor-H2|_TO_|Acceptor|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Homoserine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3602 ) or ( META1_4456 ) or ( META1_1689_metX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative homoserine O-acetyltransferase ) or ( putative hydrolase ) or ( homoserine O-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: homocysteine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.31</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERCURY__45__II__45__REDUCTASE__45__RXN" name="Mercury (II) reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2635_merA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative mercuric reductase (MerA) )</html:p>
<html:p>SUBSYSTEM: phenylmercury acetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.16.1.1</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HG__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HG0" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBPSYN__45__RXN" name="carbamoyl-phosphate synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0858_carB ) or ( META1_0440_carA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbamoyl phosphate synthase, large subunit//CARBPSYN-RXN ) or ( carbamoyl phosphate synthetase, glutamine amidotransferase small subunit//CARBPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FARNESYLTRANSTRANSFERASE__45__RXN" name="geranylgeranyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB ) or ( META1_2924_crtE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN ) or ( geranylgeranyl pyrophosphate synthase )</html:p>
<html:p>SUBSYSTEM: geranylgeranyldiphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: heptaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.29</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOHEMEFERROCHELAT__45__RXN" name="Ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1363_hemH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ferrochelatase (Protoheme ferro-lyase) (Heme synthetase)//PROTOHEMEFERROCHELAT-RXN//Ferrochelatase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDROG__45__RXN" name="Prephenate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1485 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cyclohexadienyl dehydrogenase (tyrC-like) )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARAGHYD__45__RXN" name="Asparaginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0670 ) or ( META1_4726 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative L-asparaginase (ansA-like) ) or ( putative periplasmic L-asparaginase (ansB) )</html:p>
<html:p>SUBSYSTEM: asparagine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOHMETRANS__45__RXN" name="glycine hydroxymethyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3384_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.1</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREONINE__45__ALDOLASE__45__RXN" name="Threonine aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5100 ) or ( META1_3334_ltaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative L-allo-threonine aldolase (ltaE-like) ) or ( Low-specificity L-threonine aldolase (Low-specificity L- TA) )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>SIDE: ACETALD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7800" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__17__46__1__46__2__45__RXN" name="4-hydroxy-3-methylbut-2-enyl diphosphate reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2713_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__4__45__HYDROXY__45__3__45__METHYLBUT__45__2__45__EN__45__1__45__YL__45__DIPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5682" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1485 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cyclohexadienyl dehydrogenase (tyrC-like) )</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.43</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__659" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__2__45__HYDROXY__45__ACID__45__OXIDASE__45__RXN" name="(S)-2-hydroxy-acid oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0694 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycolate oxidase (glcD-like), FAD-linked subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__2__45__Hydroxyacids1__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1941" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2002_dkgA ) or ( META2_0870_dkgA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,5-diketo-D-gluconate reductase A//1.1.1.274-RXN//RXN0-1941 ) or ( 2,5-diketo-D-gluconate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.274</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHYL__45__2__45__METHYLACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHYL__45__2R__45__METHYL__45__3S__45__HYDROXYBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5289" name="2-hydroxy-3-oxopropionate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2846 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2-hydroxy-3-oxopropionate reductase//2-hydroxy-3-oxopropionate reductase )</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.60</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITDEH__45__RXN" name="Isocitrate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3354_icd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent isocitrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THRESYN__45__RXN" name="Threonine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3465_thrC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( threonine synthase )</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3413 ) or ( META1_1685 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative 1-acylglycerol-3-phosphate O-acyltransferase (plsC)//1-acylglycerol-3-phosphate O-acyltransferase ) or ( putative 1-acylglycerol-3-phosphate O-acyltransferase (plsC)//1-acylglycerol-3-phosphate O-acyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.51</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA__45__CARBOXYLTRANSFER__45__RXN" name="Acetyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4889_accD ) or ( META1_0866_accC ) or ( META1_0865_accB ) or ( META1_5183_accA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA carboxylase, carboxyltransferase subunit beta//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055 ) or ( acetyl CoA carboxylase, biotin carboxylase subunit//BIOTIN-CARBOXYL-RXN ) or ( acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit ) or ( acetyl-CoA carboxylase, carboxytransferase subunit alpha//ACETYL-COA-CARBOXYLTRANSFER-RXN//RXN0-5055 )</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis initiation (E. coli)</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis I (E. coli)</html:p>
<html:p>SUBSYSTEM: fatty acid biosynthesis initiation I</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4282 ) or ( META1_5053 ) or ( META1_2707 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative branched-chain amino acid aminotransferase ) or ( putative branched-chain amino acid aminotransferase ) or ( putative branched-chain amino acid transferase (ilvE-like) )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5293" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4598 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate-semialdehyde dehydrogenase I, NADP-dependent (gabD-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OPPSYN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTPRATPHYD__45__RXN" name="Phosphoribosyl-ATP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2520_hisE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosyl-ATP pyrophosphatase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.31</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BHBDCLOS__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3452 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate I</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYT__45__UBIQUINOL__45__OXID__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1160_cydA ) or ( META1_0527_qxtB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome d terminal oxidase, polypeptide subunit I ) or ( Cytochrome bd ubiquinol oxidase, subunit II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDPHOSDEHYD__45__RXN" name="Imidazoleglycerol-phosphate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2515_hisB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( imidazoleglycerol-phosphate dehydratase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Aspartate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2896_asdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate-semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.11</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPPYPHOSKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3408_relA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP pyrophosphokinase )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE__45__5DP__45__3DP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLMALONYL__45__COA__45__MUT__45__RXN" name="Methylmalonyl-CoA mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2390_mcmB ) or ( META1_5251_mcmA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Methylmalonyl-CoA mutase, beta subunit//Methylmalonyl-CoA mutase ) or ( methylmalonyl-CoA mutase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Protein__45__Dithiols__124___TO___124__Protein__45__Disulfides__124___COF_RXN" name="|Protein-Dithiols|_TO_|Protein-Disulfides|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Dithiols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LCYSDESULF__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0417 ) or ( META1_4647_metC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA/RNA non-specific endonuclease ) or ( cystathionine beta-lyase, PLP-dependent (beta-cystathionase)//CYSTATHIONINE-BETA-LYASE-RXN )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NARINGENIN__45__3__45__DIOXYGENASE__45__RXN" name="Naringenin 3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1642 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 2OG-Fe(II) oxygenase superfamily )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.9</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROKAEMPFEROL__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAPASYN__45__RXN" name="Adenosylmethionine--8-amino-7-oxononanoate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0619_bioA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7,8-diaminopelargonic acid synthetase, PLP-dependent (Adenosylmethionine-8-amino-7-oxononanoate aminotransferase)//DAPASYN-RXN )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.62</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_8__45__AMINO__45__7__45__OXONONANOATE" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE1EPIM__45__RXN" name="ALDOSE-1-EPIMERASE" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3078_galM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldose-1-epimerase (Galactose mutarotase)//ALDOSE1EPIM-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__1__46__6__45__RXN" name="biotin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4394_bioB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthetase//2.8.1.6-RXN )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: CH33ADO</html:p>
<html:p>SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: MET</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
      <speciesReference species="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIPHENYL__45__23__45__DIOL__45__12__45__DIOXYGENASE__45__RXN" name="Biphenyl-2,3-diol 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4449 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Biphenyl-2,3-diol 1,2-dioxygenase III )</html:p>
<html:p>SUBSYSTEM: biphenyl degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.39</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIPHENYL__45__23__45__DIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOPRIBOTRANS__45__RXN" name="Nicotinate-nucleotide pyrophosphorylase (carboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2837_nadC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate-mononucleotide pyrophosphorylase//QUINOPRIBOTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.19</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNREDUC__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3381_ribD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused diaminohydroxyphosphoribosylaminopyrimidine deaminase;5-amino-6-(5-phosphoribosylamino) uracil reductase//RIBOFLAVINSYNDEAM-RXN//RIBOFLAVINSYNREDUC-RXN )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.193</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1086" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__P__45__OR__45__NOP_TO_NADH__45__P__45__OR__45__NOP_COF_RXN" name="NAD-P-OR-NOP_TO_NADH-P-OR-NOP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0144_arsC3 ) or ( META2_0145_arsC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arsenate reductase ) or ( arsenate reductase//RXN-982 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__296" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOIC__45__ACID" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__763" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__17__45__RXN" name="L-serine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4112_sdaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-serine deaminase//4.3.1.17-RXN )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: L-serine degradation</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAM__45__RXN" name="Phosphoserine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0485_serC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSGLYPHOS__45__RXN" name="Phosphoglycerate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2369_pgk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate kinase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7836" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3452 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTPSYN__45__RXN" name="CTP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5110_pyrG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CTP synthetase//CTPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Serine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4592_sga ) or ( META1_1726_sga )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine-glyoxylate aminotransferase ) or ( serine-glyoxylate aminotransferase (SGAT) )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7838" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4879 ) or ( META1_4632 ) or ( META1_3452 ) or ( META1_5098_croA ) or ( META1_3870 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase ) or ( putative enoyl-CoA hydratase/isomerase family protein ) or ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase ) or ( 3-hydroxybutyryl-CoA dehydratase ) or ( Enoyl-CoA hydratase/isomerase family protein//Enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cis__45__2__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNDEACET__45__RXN" name="Acetylornithine deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0283_argE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Acetylornithine deacetylase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROPORIIIMETHYLTRANSA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3434_cysG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Siroheme synthase//DIMETHUROPORDEHYDROG-RXN//RXN-8675//SIROHEME-FERROCHELAT-RXN//UROPORIIIMETHYLTRANSA-RXN )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__GLN__45__RXN" name="NAD(+) synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4425_nadE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(+) synthase (glutamine-hydrolyzing) with a nitrilase-like domain//NAD(+) synthase (glutamine-hydrolyzing) )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UREIDOGLYCOLATE__45__HYDROLASE__45__RXN" name="Ureidoglycolate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1666_allA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ureidoglycolate hydrolase )</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLTHFGLUSYNTH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4888_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional folylpolyglutamate synthase and dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7001" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3170_xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthosine phosphorylase (purine nucleoside phosphorylase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARSENATE" stoichiometry="1"/>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5234" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3384_glyA ) or ( META1_5100 ) or ( META1_3334_ltaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) or ( putative L-allo-threonine aldolase (ltaE-like) ) or ( Low-specificity L-threonine aldolase (Low-specificity L- TA) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLO__45__THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5444" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4535_mxaI ) or ( META1_4538_mxaF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Methanol dehydrogenase subunit 2 precursor (MDH small beta subunit) ) or ( Methanol dehydrogenase subunit 1 precursor (MDH large alpha subunit) (MEDH) )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__INDOLEGLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__KETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMP__45__DEHYDROG__45__RXN" name="IMP dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3145_guaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IMP dehydrogenase )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: guanosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.205</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XMPXAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2085 ) or ( META1_2566_soxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypothetical protein, putative 5&apos;-nucleotidase domain//5&apos;-nucleotidase ) or ( sulfur/thiosulfate oxidation protein precursor (tat pathway signal) )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5240" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3384_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8783" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0437_gnl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gluconolactonase (D-glucono-delta-lactone lactonohydrolase)//Gluconolactonase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GULONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__13__46__3__45__RXN" name="Histidine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( META2_0169 ) or (  ) or ( META1_1129 ) or (  ) or (  ) or ( META2_0371 ) or ( META1_5332 ) or ( META1_0525 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multi-sensor hybrid histidine kinase (fragment) ) or ( Periplasmic sensor signal transduction histidine kinase ) or ( fragment of putative PAS sensor histidine kinase/response regulator (N-terminal fragment) ) or ( putative multi-sensor hybrid histidine kinase ) or ( PAS/PAC sensor signal transduction histidine kinase (fragment) ) or ( fragment of putative PAS sensor histidine kinase/response regulator (C-terminal fragment) ) or ( putative sensor histidine kinase ) or ( putative histidine kinase ) or ( Two-component sensor histidine kinase with a PAS domain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.13.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3PGAREARR__45__RXN" name="Phosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( META1_1116_gpmA ) or ( META1_2472_gpmA ) or ( META1_4686 ) or ( META1_1218_gpmA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phosphoglyceromutase (fragment) ) or ( phosphoglyceromutase//3PGAREARR-RXN ) or ( phosphoglyceromutase//3PGAREARR-RXN ) or ( putative phosphoglycerate mutase ) or ( Phosphoglyceromutase//3PGAREARR-RXN )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8789" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9088" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9089" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSEPHOSPHA__45__RXN" name="Trehalose-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4841 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative trehalose-6-phosphate phosphatase (otsB) )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLGLUTPREDUCT__45__RXN" name="N-acetyl-&amp;gamma;-glutamyl-phosphate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4920_argC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglutamate semialdehyde dehydrogenase (NAGSA dehydrogenase) or N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding//N-ACETYLGLUTPREDUCT-RXN )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__469" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URACIL__45__PRIBOSYLTRANS__45__RXN" name="Uracil phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1439_upp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uracil phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8787" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2926_bchC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase )</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9065" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9066" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOPHOSPHORYL__45__RXN" name="glycogen phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2008_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R524__45__RXN" name="Cyanate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2966_cynS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cyanate lyase )</html:p>
<html:p>SUBSYSTEM: cyanate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.104</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="CPD__45__69" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLTRANSFER__45__RXN" name="Amino-acid N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0204_argJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate N-acetyltransferase/amino-acid acetyltransferase )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPISOM__45__RXN" name="Mannose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0949 ) or ( META1_5003 ) or ( META1_5250_algA ) or ( META1_4523 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative mannose-6-phosphate isomerase ) or ( putative mannose-6-phosphate isomerase ) or ( Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase ) or ( Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: D-mannose degradation</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__NUCLEOTID__45__RXN" name="5&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4626_surE ) or ( META1_2085 ) or ( META1_2566_soxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase) ) or ( hypothetical protein, putative 5&apos;-nucleotidase domain//5&apos;-nucleotidase ) or ( sulfur/thiosulfate oxidation protein precursor (tat pathway signal) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__REDUCT__45__NADPH__45__RXN" name="Glutathione reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2302_gor )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione reductase//GLUTATHIONE-REDUCT-NADPH-RXN )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions II</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8791" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9090" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9067" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__6__45__RXN" name="Undecaprenyl-phosphate galactosephosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1788 ) or ( META1_4518 ) or ( META2_0441 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycosyl transferase ) or ( putative Undecaprenyl-phosphate galactosephosphotransferase ) or ( putative glycosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="CPD__45__191" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8794" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9098" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9099" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3384_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOLATE__45__REDUCTASE__45__RXN" name="Glycolate reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4799 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycerate dehydrogenase (gyaR-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.26</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPONTPRO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__NAD__43____45__RXN" name="DNA ligase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0992_ligA ) or ( META1_5091_dnlJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA ligase, NAD(+)-dependent//DNA-LIGASE-NAD+-RXN ) or ( DNA ligase, NAD(+)-dependent )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2085 ) or ( META1_2566_soxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypothetical protein, putative 5&apos;-nucleotidase domain//5&apos;-nucleotidase ) or ( sulfur/thiosulfate oxidation protein precursor (tat pathway signal) )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8790" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9089" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9090" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CPD__45__558_TO_CO__45__A_COF_RXN" name="CPD-558_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CPD__45__558" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8796" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9100" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9096" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8795" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5279_bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9099" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9100" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYKIN__45__RXN" name="Diacylglycerol kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4867 ) or ( META1_3424 ) or ( META1_1458 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative diacylglycerol kinase related protein ) or ( putative diacylglycerol kinase (dgkA-like) ) or ( putative diacylglycerol kinase. )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.107</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THF_TO_10__45__FORMYL__45__THF_COF_RXN" name="THF_TO_10-FORMYL-THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5424" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4535_mxaI ) or ( META1_4538_mxaF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Methanol dehydrogenase subunit 2 precursor (MDH small beta subunit) ) or ( Methanol dehydrogenase subunit 1 precursor (MDH large alpha subunit) (MEDH) )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__INDOLYLGLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BTUR2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1337_cobO ) or ( META1_1433_meaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cob(I)yrinic acid a,c-diamide adenosyltransferase (Cob(I)alamin adenosyltransferase) (Corrinoid adenosyltransferase)//Cob(I)yrinic acid a,c-diamide adenosyltransferase ) or ( cobalamin adenosyltransferase, methylmalonyl-CoA mutase cofactor biosynthesis protein )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="COBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__GENERIC__45__RXN" name="alcohol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3803 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Zn-containing alcohol dehydrogenase (adh) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__45__Or__45__Ketones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISPH2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2713_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__99__46__28__45__RXN" name="Glucose--fructose oxidoreductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3462 ) or ( META1_4987 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxidoreductase precursor (tat pathway signal) ) or ( putative oxidoreductase precursor (tat pathway signal) )</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.28</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3652_aldB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase; chloroacetaldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.4</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARTRANSFORM__45__RXN" name="Phosphoribosylaminoimidazolecarboxamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2535_purH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: IMP cyclohydrolase (N-terminal); phosphoribosylaminoimidazolecarboxamide formyltransferase (C-terminal)//AICARTRANSFORM-RXN//IMPCYCLOHYDROLASE-RXN//IMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.3</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AICAR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLACYLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4879 ) or ( META1_4632 ) or ( META1_3452 ) or ( META1_5098_croA ) or ( META1_3870 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase ) or ( putative enoyl-CoA hydratase/isomerase family protein ) or ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase ) or ( 3-hydroxybutyryl-CoA dehydratase ) or ( Enoyl-CoA hydratase/isomerase family protein//Enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1882" name="GDP-mannose 3,5-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4519_gme )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-mannose 3,5-epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__L__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DXPREDISOM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2068_dxr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomerase) (2-C- methyl-D-erythritol 4-phosphate synthase)//DXPREDISOM-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.267</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2079 ) or ( META1_4949_tkt ) or ( META1_1861_tkt ) or ( META1_2078 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative transketolase (C-terminal domain) ) or ( transketolase ) or ( transketolase ) or ( putative transketolase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__148__45__RXN" name="4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3320_ispE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (4-(cytidine-5&apos;-diphospho)-2-C-methyl-D-erythritol kinase)//2.7.1.148-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.148</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LUMAZINESYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3375_ribE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (Lumazine synthase) (Riboflavin synthase beta chain)//Riboflavin synthase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__BUTANONE__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5070 ) or ( META1_2016 ) or ( META1_0148 ) or ( META1_3485_galE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( Putative UDP-glucose 4-epimerase//UDP-glucose 4-epimerase ) or ( UDP-galactose 4-epimerase//UDPGLUCEPIM-RXN )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__64__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5206 ) or ( META1_0733 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-demethylubiquinone-9 3-methyltransferase ) or ( putative UbiG: ubiquinone biosynthesis O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9957" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LTAA__45__RXN" name="L-allo-threonine aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3384_glyA ) or ( META1_3334_ltaE ) or ( META1_5100 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase//GLYOHMETRANS-RXN ) or ( Low-specificity L-threonine aldolase (Low-specificity L- TA) ) or ( putative L-allo-threonine aldolase (ltaE-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALLO__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5408" name="Myo-inositol-1(or 4)-monophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0426_suhB ) or ( META1_0663 ) or ( META1_5008 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol monophosphatase//RXN0-5408 ) or ( putative inositol monophosphatase (suhB-like) ) or ( putative inositol mono-phosphatase (suhB-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__MYO__45__INOSITOL__45__1__45__MONOPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__6__45__OHPHENOL__45__METHY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5206 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-demethylubiquinone-9 3-methyltransferase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__METHOXYPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5405" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5088_ftsI ) or ( META1_5233_pbpC ) or ( META1_1283_pbpC ) or ( META1_0533 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peptidoglycan glycosyltransferase (penicillin-binding protein)//Peptidoglycan glycosyltransferase ) or ( penicillin-binding protein ) or ( penicillin binding protein//RXN0-5405 ) or ( Penicillin-binding protein 1A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.129</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C6" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1178" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1179" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONOLACT__45__RXN" name="6-phosphogluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5284_pgl ) or ( META1_1866_pgl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase ) or ( 6-phosphogluconolactonase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.31</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRNA__45__PSEUDOURIDINE__45__SYNTHASE__45__I__45__RXN" name="tRNA-pseudouridine synthase I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2888_truB ) or ( META1_1528_truA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA pseudouridine synthase B (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA-uridine isomerase) (tRNA pseudouridylate synthase) ) or ( tRNA pseudouridine synthase A (tRNA-uridine isomerase I) (tRNA pseudouridylate synthase I)//TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8538" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8537" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_ADP_COF_RXN" name="ATP_TO_ADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCISOM__45__RXN" name="Glucose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4950 ) or ( META1_1862 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Transaldolase Phosphoglucose isomerase//Transaldolase ) or ( putative Transaldolase Phosphoglucose isomerase//Transaldolase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THI__45__P__45__SYN__45__RXN" name="Thiamine-phosphate pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4916_thiE ) or ( META1_0427_thiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) (TMP-PPase) (thiamine-phosphate synthase)//THI-P-SYN-RXN ) or ( thiamine-phosphate pyrophosphorylase (TMP pyrophosphorylase) (TMP-PPase) (thiamine-phosphate synthase)//THI-P-SYN-RXN )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THZ__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITSYN__45__RXN" name="Citrate (si)-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5129_gltA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( citrate synthase//CITSYN-RXN )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTKIN__45__RXN" name="Glutamate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3071_proB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glutamate 5-kinase (Gamma-glutamyl kinase) (GK)//GLUTKIN-RXN//Glutamate 5-kinase )</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPIDADISACCHARIDESYNTH__45__RXN" name="Lipid-A-disaccharide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5127_lpxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Lipid-A-disaccharide synthase )</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.182</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BISOHMYR__45__GLUCOSAMINYL__45__1P" stoichiometry="1"/>
      <speciesReference species="OH__45__MYRISTOYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BISOHMYR__45__GLC" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHHB__45__METHYLTRANSFER__45__RXN" name="3-demethylubiquinone-9 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5206 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-demethylubiquinone-9 3-methyltransferase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__OH__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9956" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4OH2OXOGLUTARALDOL__45__RXN" name="4-hydroxy-2-oxoglutarate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1985_eda )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase//4OH2OXOGLUTARALDOL-RXN//KDPGALDOL-RXN//OXALODECARB-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__4__45__HYDROXY__45__2__45__KETO__45__GLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16BDEPHOS__45__RXN" name="Fructose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1940_glpX ) or ( META1_0757_cbbF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose 1,6-bisphosphatase II//F16BDEPHOS-RXN ) or ( fructose-1,6-bisphosphatase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__20__45__RXN" name="Methylenetetrahydrofolate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1493_metF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5,10-methylenetetrahydrofolate reductase//1.5.1.20-RXN )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.20</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDE__45__GLUCOSYLTRANSFERASE__45__RXN" name="Ceramide glucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0541 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ceramide glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.80</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ceramides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Glucosyl__45__Ceramides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVOXID__45__RXN" name="Pyruvate dehydrogenase (cytochrome)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1455_poxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( poxB; pyruvate dehydrogenase/oxidase: FAD- and thiamin PPi-binding//PYRUVOXID-RXN )</html:p>
<html:p>SUBSYSTEM: pyruvate oxidation pathway</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.2.2.2</html:p>
<html:p>SIDE: UBIQUINOL__45__8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UBIQUINONE__45__8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__KINASE__45__RXN" name="Protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4499 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RecA-superfamily ATPase implicated in signal transduction )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTEPADENYLYLTRAN__45__RXN" name="Pantetheine-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5018_coaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pantetheine-phosphate adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.3</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__33__45__RXN" name="Glucose-1-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0612_rfbF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-D-glucose-1-phosphate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.33</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_7KAPSYN__45__RXN" name="8-amino-7-oxononanoate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1820_rkpG ) or ( META1_0624_bioF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyltransferase (wcbT-like, rkpG-like) ) or ( 7-keto-8-aminopelargonic acid synthetase (8-amino-7-oxononanoate synthase//7KAPSYN-RXN//8-amino-7-oxononanoate synthase )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.47</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CPD__45__558</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_8__45__AMINO__45__7__45__OXONONANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__3__46__11__45__RXN" name="Pyrroloquinoline-quinone synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1749_pqqCD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional coenzyme pyrroloquinoline quinone (PQQ) biosynthesis protein pyrroloquinoline-quinone synthase/PQQ synthesis protein D )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7244" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7245" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTACETYLTRAN__45__RXN" name="Maltose O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4639_maa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maltose o-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.79</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLMALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R122__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3231 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative hydroxydechloroatrazine ethylaminohydrolase (AtzB) (Hydroxyatrazine hydrolase) )</html:p>
<html:p>SUBSYSTEM: atrazine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ETHANAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYATRAZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANAMINE" stoichiometry="1"/>
      <speciesReference species="N__45__ISOPROPYLAMMELIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3701_phaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetoacetyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOLINATE__45__SYNTHA__45__RXN" name="quinolinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2835 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative quinolinate synthetase A (nadA-like) )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.72</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: DIHYDROXY__45__ACETONE__45__PHOSPHATE</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="IMINOASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIP__45__KIN__45__RXN" name="Nucleoside-diphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1990_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINAMID__45__RXN" name="Nicotinamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4281_pncA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinamidase//NICOTINAMID-RXN )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.19</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIOSEPISOMERIZATION__45__RXN" name="Triosephosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5115_tpiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triosephosphate isomerase//TRIOSEPISOMERIZATION-RXN )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3SC23OSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: orthanilate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8218" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8720" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__AMINOLEVULINIC__45__ACID__45__SYNTHASE__45__RXN" name="5-aminolevulinic acid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( META2_1124_hemT ) or ( META1_1968_hemA ) or ( META1_5261_hemA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 5-aminolevulinate synthase (fragment)//5-aminolevulinate synthase ) or ( 5-aminolevulinate synthase ) or ( 5-aminolevulinic acid synthase (ALAS) ) or ( 5-aminolevulinic acid synthase (ALAS) )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.37</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5226" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3626 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative beta N-acetyl-glucosaminidase (nagZ-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.52</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__882" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5225" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3918 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative N-acetylmuramoyl-L-alanine amidase amiC precursor//N-acetylmuramoyl-L-alanine amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1080" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1082" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R341__45__RXN" name="hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5236 ) or ( META1_0805_cobB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative cobyrinic acid a,c-diamide synthase ) or ( cobyrinic acid a,c-diamide synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__687" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__688" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Serine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4592_sga ) or ( META1_1726_sga )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine-glyoxylate aminotransferase ) or ( serine-glyoxylate aminotransferase (SGAT) )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5228" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2870_ycjG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-Ala-D/L-Glu epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALA__45__GAMMA__45__D__45__GLU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1445" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8762" name="Precorrin-4 C11-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0804_cobM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-4 C(11)-methyltransferase (Precorrin-3 methylase)//Precorrin-4 C(11)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.133</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9042" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEHYDROGENASE__45__ACCEPTOR__45__RXN" name="Malate dehydrogenase (acceptor)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1401_mqo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate dehydrogenase, FAD/NAD(P)-binding domain (tat pathway signal)//MALATE-DEHYDROGENASE-ACCEPTOR-RXN )</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TIGLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4879 ) or ( META1_4632 ) or ( META1_3452 ) or ( META1_5098_croA ) or ( META1_3870 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase ) or ( putative enoyl-CoA hydratase/isomerase family protein ) or ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase ) or ( 3-hydroxybutyryl-CoA dehydratase ) or ( Enoyl-CoA hydratase/isomerase family protein//Enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8761" name="Precorrin-3B C17-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1324_cobJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Precorrin-3B C(17)-methyltransferase (Precorrin-3 methyltransferase) (Precorrin-3 methylase)//Precorrin-3B C(17)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.131</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9040" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9041" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2NEOPTERINALDOL__45__RXN" name="Dihydroneopterin aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1744_folB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroneopterin aldolase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.25</html:p>
<html:p>SIDE: GLYCOLALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__NEO__45__PTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
      <speciesReference species="GLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__80__45__RXN" name="N-acetylgalactosamine-6-phosphate deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4722 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative N-acetylglucosamine-6-phosphate deacetylase (nagA-like)//N-acetylglucosamine-6-phosphate deacetylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="D__45__GALACTOSAMINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPAMIDOTRANS__45__RXN" name="Amidophosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4314_purF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidophosphoribosyltransferase (PRPP amidotransferase)//PRPPAMIDOTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.14</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDP_TO_CTP_COF_RXN" name="CDP_TO_CTP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOSEPHOSPHO__45__RXN" name="Protein-N(PI)-phosphohistidine-sugar phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1020 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative PTS system subfamily mannose/fructose-specific IIA component )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.69</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__3__45__phospho__45__L__45__histidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Histidines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__12__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1009 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 6-pyruvol tetrahydrobiopterin synthase )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.12</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7241" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0512 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Prepilin peptidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6741" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2480 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glycoside hydrolase, family 3, N-terminal and C-terminal domain (bglX-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINAMARIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXY__45__2__45__METHYLPROPANENITRILE" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__OXIDASE__45__RXN" name="Sulfite oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2567_soxC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfite oxidase precursor (tat pathway signal) )</html:p>
<html:p>SUBSYSTEM: sulfite oxidation IV</html:p>
<html:p>PROTEIN_CLASS: 1.8.3.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4879 ) or ( META1_4632 ) or ( META1_3452 ) or ( META1_5098_croA ) or ( META1_3870 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase ) or ( putative enoyl-CoA hydratase/isomerase family protein ) or ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase ) or ( 3-hydroxybutyryl-CoA dehydratase ) or ( Enoyl-CoA hydratase/isomerase family protein//Enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QOR__45__RXN" name="NADPH:quinone reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_1211 ) or ( META1_1438 ) or ( META1_4280_qor ) or ( META1_0735 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADPH quinone oxidoreductase, Zinc-containing alcohol dehydrogenase superfamily ) or ( putative NADPH quinone oxidoreductase ) or ( quinone oxidoreductase, NADPH-dependent//QOR-RXN ) or ( Zn-binding quinone oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Semiquinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCONDEHYDRAT__45__RXN" name="Phosphogluconate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1986_edd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydratase//PGLUCONDEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEPHOSPHORYLATION__45__RXN" name="5&apos;-nucleotidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4626_surE ) or ( META1_2085 ) or ( META1_2566_soxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-nucleotidase surE (Nucleoside 5&apos;-monophosphate phosphohydrolase) ) or ( hypothetical protein, putative 5&apos;-nucleotidase domain//5&apos;-nucleotidase ) or ( sulfur/thiosulfate oxidation protein precursor (tat pathway signal) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PABASYN__45__RXN" name="Aminodeoxychorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4284_pabB ) or ( META1_4283_pabA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( para-aminobenzoate synthase component I (ADC synthase)//PABASYN-RXN ) or ( aminodeoxychorismate synthase subunit II, component of p-aminobenzoate synthase multienzyme complex//PABASYN-RXN )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.85</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4465_argF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine carbamoyltransferase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: CARBAMOYL__45__P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTERIDINEPYROPHOSPHOKIN__45__RXN" name="2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1743_folK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, PPPK)//H2PTERIDINEPYROPHOSPHOKIN-RXN )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDPGALDOL__45__RXN" name="2-dehydro-3-deoxyphosphogluconate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1985_eda )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional: 2-keto-3-deoxygluconate 6-phosphate aldolase; 2-keto-4-hydroxyglutarate aldolase; oxaloacetate decarboxylase//4OH2OXOGLUTARALDOL-RXN//KDPGALDOL-RXN//OXALODECARB-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4817 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative NAD binding site:Amine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__30" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATREDUCT__45__RXN" name="Nitrate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3433_nasA ) or ( META1_1806 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrate reductase, large subunit ) or ( putative molybdopterin oxidoreductase )</html:p>
<html:p>SUBSYSTEM: nitrate reduction I (denitrification)</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.4</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__0" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4544 ) or ( META1_2899_speG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glmU-like gene; bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal) ) or ( spermidine N1-acetyltransferase//DIAMACTRANS-RXN//SPERMACTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCC__45__FUM__45__OXRED__45__RXN" name="Succinate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3863_sdhB ) or ( META1_3861_sdhA/B ) or ( META1_3859_sdhC ) or ( META1_3570 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate dehydrogenase, iron-sulfur subunit ) or ( succinate dehydrogenase, flavoprotein subunit ) or ( succinate dehydrogenase, cytochrome b556 subunit ) or ( putative Succinate dehydrogenase flavoprotein subunit//Succinate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAPHTHALENE__45__12__45__DIOXYGENASE__45__RXN" name="Naphthalene 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4120 ) or ( META1_3008 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Iron-sulphur Rieske protein ) or ( putative Naphthalene 1,2-dioxygenase subunit alpha (Naphthalene 1,2-dioxygenase ISP alpha) )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAPHTHALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__12__45__DIHYDRONAPHTHALENE__45__12__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETRAACYLDISACC4KIN__45__RXN" name="Tetraacyldisaccharide 4&apos;-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3173_lpxK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tetraacyldisaccharide 4&apos;-kinase )</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.130</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BISOHMYR__45__GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPID__45__IV__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALARACECAT__45__RXN" name="Alanine racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4319 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative alanine racemase (alr-like) )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5193_psd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine decarboxylase (psd-like) )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylethanolamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.65</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5063" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3415_miaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA modification enzyme MiaB, putative isopentenyl-adenosine A37 tRNA methylthiolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__6__45__ISOPENTYL__45__ADENOSINE__45__37__45__TRNA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYLTHIO__45__N__45__6__45__ISOPENTYL__45__ADENOSINE__45__37__45__" stoichiometry="1"/>
      <speciesReference species="CH33ADO" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__99__46__3__45__RXN" name="Aldehyde dehydrogenase (pyrroloquinoline-quinone)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4977 ) or ( META1_0685 ) or ( META2_0885 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aldehyde dehydrogenase precursor (tat pathway signal) ) or ( putative aldehyde dehydrogenase precursor (tat pathway signal) ) or ( Putative membrane-bound aldehyde dehydrogenase [pyrroloquinoline-quinone-linked] )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCOSEPP__45__RXN" name="Glucose-1-phosphate thymidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4039_rffH ) or ( META1_2397_rffH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Glucose-1-phosphate thymidylyltransferase ) or ( Glucose-1-phosphate thymidylyltransferase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.24</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTASE__45__RXN" name="Aspartate ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4341_aspA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aspartate ammonia-lyase (Aspartase)//ASPARTASE-RXN//Aspartate ammonia-lyase )</html:p>
<html:p>SUBSYSTEM: glutamate degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARDIOLIPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4881_cls )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cardiolipin synthase (cls-like) )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>SIDE: GLYCEROL</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARDIOLIPIN" stoichiometry="1"/>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYMETHYLENEBUTENOLIDASE__45__RXN" name="Carboxymethylenebutenolidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1735 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative carboxymethylenebutenolidase precursor (dienelactone hydrolase) (tat pathway signal) )</html:p>
<html:p>SUBSYSTEM: 4-chlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.45</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CARBOXYMETHYLENEBUT__45__2__45__EN__45__4__45__OLIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMIDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2519_hisF ) or ( META1_2517_hisH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( imidazole glycerol phosphate synthase, subunit with HisH ) or ( glutamine amidotransferase, subunit with HisF )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2301" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2223_mcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylsuccinyl-CoA dehydrogenase, putative isobutyryl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATEPRIBOSYLTRANS__45__RXN" name="Nicotinate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5011 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nicotinate phosphoribosyltransferase (NAPRTase)//Nicotinate phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.11</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8529" name="4-oxalocrotonate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2136 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-oxalocrotonate tautomerase )</html:p>
<html:p>SUBSYSTEM: catechol degradation to 2-oxopent-4-enoate II</html:p>
<html:p>SUBSYSTEM: orthanilate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8720" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__246" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPICRED__45__RXN" name="Dihydrodipicolinate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2473_dapB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrodipicolinate reductase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.26</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1990_ndk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase//CDPKIN-RXN//DADPKIN-RXN//DCDPKIN-RXN//DGDPKIN-RXN//DTDPKIN-RXN//DUDPKIN-RXN//GDPKIN-RXN//NUCLEOSIDE-DIP-KIN-RXN//UDPKIN-RXN )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYRIBOSE__45__P__45__ALD__45__RXN" name="Deoxyribose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3169_deoC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-deoxyribose-5-phosphate aldolase, NAD(P)-linked//DEOXYRIBOSE-P-ALD-RXN )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__141__45__RXN" name="4-&amp;alpha;-D-{(1->4)-&amp;alpha;-D-glucano}-trehalose trehalohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2904 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative malto-oligosyltrehalose trehalohydrolase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.141</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOOLIGOSYLTREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPIONYL__45__COA__45__CARBOXY__45__RXN" name="Propionyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3203_pccA ) or ( META1_0172_pccB ) or ( META1_0025_mdcD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( propionyl-CoA carboxylase alpha subunit ) or ( propionyl-CoA carboxylase beta chain ) or ( malonate decarboxylase, beta-subunit )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TARTRATE__45__DECARBOXYLASE__45__RXN" name="Tartrate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5136_ttuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tartrate dehydrogenase/decarboxylase (TDH) (D-malate dehydrogenase [decarboxylating])//Tartrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.73</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__DECARBOXYLASE__45__RXN" name="UDP-glucuronate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4521 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative sugar nucleotide dehydratase )</html:p>
<html:p>SUBSYSTEM: UDP-D-xylose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.35</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="Myo-inositol-1(or 4)-monophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0426_suhB ) or ( META1_0663 ) or ( META1_5008 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol monophosphatase//RXN0-5408 ) or ( putative inositol monophosphatase (suhB-like) ) or ( putative inositol mono-phosphatase (suhB-like) )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETATEKIN__45__RXN" name="Acetate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1891 ) or ( META1_3807 ) or ( META1_0383 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acetate kinase, propionate kinase ) or ( putative acetate kinase (partial) ) or ( putative acetate kinase (ackA) )</html:p>
<html:p>SUBSYSTEM: pyruvate oxidation pathway</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: acetate formation from acetyl-CoA I</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate II</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate IV</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>SUBSYSTEM: superpathway of acetate utilization and formation</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTMPKI__45__RXN" name="Thymidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4582_tmk ) or ( META2_0607 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate kinase//DTMPKI-RXN ) or ( thymidylate kinase )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTAGLY__45__RXN" name="Cystathionine &amp;gamma;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0417 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA/RNA non-specific endonuclease )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE__45__1__45__EPIMERASE__45__RXN" name="Aldose 1-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3078_galM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aldose-1-epimerase (Galactose mutarotase)//ALDOSE1EPIM-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__ALANINE__45__AMINOTRANSFERASE__45__RXN" name="D-alanine aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0774 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative D-amino-acid transaminase (D-alanine aminotransferase)//D-amino-acid transaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYMETVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1928 ) or ( META1_2868_ilvD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dihydroxyacid dehydratase (ilvD-like) ) or ( dihydroxyacid dehydratase//DIHYDROXYISOVALDEHYDRAT-RXN//DIHYDROXYMETVALDEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I (from threonine)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8925" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3113 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VANILLIN" stoichiometry="1"/>
      <speciesReference species="__124__Amineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9327" stoichiometry="1"/>
      <speciesReference species="__124__Deamineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINLYA__45__RXN" name="Argininosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3503_argH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPNACETYLGLUCOSAMENOLPYRTRANS__45__RXN" name="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1964_murA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine 1-carboxyvinyltransferase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.7</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NACGLCTRANS__45__RXN" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3147_murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase//NACGLCTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C5" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4879 ) or ( META1_4632 ) or ( META1_3452 ) or ( META1_5098_croA ) or ( META1_3870 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase ) or ( putative enoyl-CoA hydratase/isomerase family protein ) or ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase ) or ( 3-hydroxybutyryl-CoA dehydratase ) or ( Enoyl-CoA hydratase/isomerase family protein//Enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMEOSYN__45__RXN" name="heme o biosynthesis" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3472_coxE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heme O synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEME_O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCDEHYDROG__45__RXN" name="Phosphoglycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0486_serA ) or ( META1_0105_serA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate dehydrogenase//PGLYCDEHYDROG-RXN ) or ( D-3-phosphoglycerate dehydrogenase//PGLYCDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.95</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTCYSLIG__45__RXN" name="Glutamate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0671_gshA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-glutamylcysteine synthetase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7698" name="Acetoacetyl-CoA reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3701_phaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetoacetyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNTRANSAM__45__RXN" name="Acetylornithine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4464_argD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinylornithine transaminase, also has acetylornitine transaminase activity, PLP-dependent )</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.11</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__469" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREOSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: aminopropanol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMPSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0773_purB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase//AICARSYN-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: adenosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENIIISYN__45__RXN" name="uroporphyrinogen-III synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0559 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative uroporphyrinogen III synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.75</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__CYCLODEAMINASE__45__RXN" name="Ornithine cyclodeaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3003_arcB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine cyclodeaminase (OCD) )</html:p>
<html:p>SUBSYSTEM: ornithine degradation (proline biosynthesis)</html:p>
<html:p>SUBSYSTEM: arginine degradation VII (arginase 3 pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETHYDPICSUCC__45__RXN" name="2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1465_dapD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase//TETHYDPICSUCC-RXN )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.117</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__SUCCINYL__45__2__45__AMINO__45__6__45__KETOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBINPGUANYLYLTRANS__45__RXN" name="Adenosylcobinamide-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1336_cobP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional adenosylcobalamin biosynthesis protein cobP )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.62</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATEREDUCT__45__RXN" name="Dihydrofolate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2852_dfrA ) or ( META2_0242_dfrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrofolate reductase ) or ( Putative dihydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCTP__45__DEAM__45__RXN" name="dCTP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0286_dcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2&apos;-deoxycytidine 5&apos;-triphosphate deaminase )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.13</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBUTYRYL__45__COA__45__DEHYDROGENASE__45__RXN" name="3-hydroxybutyryl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1436_hbdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxybutyryl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.157</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__3__45__HYDROXYBUTANOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7693" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3803 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Zn-containing alcohol dehydrogenase (adh) )</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7031" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7032" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNDEAM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3381_ribD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused diaminohydroxyphosphoribosylaminopyrimidine deaminase;5-amino-6-(5-phosphoribosylamino) uracil reductase//RIBOFLAVINSYNDEAM-RXN//RIBOFLAVINSYNREDUC-RXN )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.26</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7694" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3803 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Zn-containing alcohol dehydrogenase (adh) )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLBUT__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7033" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9023" name="disproportionating enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2905 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative malto-oligosyltrehalose synthase )</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Truncated__45__Limit__45__Dextrins__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCDEHYDRAT__45__RXN" name="dTDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0147 ) or ( META1_2395_rffG ) or ( META1_4041_rffG ) or ( META1_0141 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dTDP-glucose 4,6-dehydratase//dTDP-glucose 4,6-dehydratase ) or ( dTDP-glucose 4,6-dehydratase ) or ( dTDP-glucose 4,6-dehydratase ) or ( putative dTDP-glucose 4,6-dehydratase//dTDP-glucose 4,6-dehydratase )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.46</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9025" name="maltodextrin phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2008_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2882" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1766_fae ) or ( META1_1339_fae ) or ( META1_3356_fae )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formaldehyde-activating enzyme ) or ( formaldehyde activating enzyme homolog ) or ( formaldehyde activating enzyme homolog )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation VI (H4MPT pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: THMPT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="THMPT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENETETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAHPSYN__45__RXN" name="2-dehydro-3-deoxyphosphoheptonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1974_aroG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-dehydro-3-deoxyphosphoheptonate aldolase )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.54</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="adenylosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0776_purA ) or ( META2_0999 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate synthetase//ADENYLOSUCCINATE-SYNTHASE-RXN ) or ( putative Adenylosuccinate synthase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: adenosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.4</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2883" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1761_mtdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation VI (H4MPT pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENETETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHENYLTETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMACTRANS__45__RXN" name="Diamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4544 ) or ( META1_2899_speG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glmU-like gene; bifunctional: N-acetyl glucosamine-1-phosphate uridyltransferase (N-terminal); glucosamine-1-phosphate acetyl transferase (C-terminal) ) or ( spermidine N1-acetyltransferase//DIAMACTRANS-RXN//SPERMACTRAN-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aliphatic__45__N__45__Acetyl__45__Diamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOGLUCMUT__45__RXN" name="Phosphoglucomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3093_pgm ) or ( META1_4513 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglucomutase ) or ( putative Phosphomannomutase/phosphoglucomutase (AlgC)//Phosphomannomutase )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>SUBSYSTEM: sucrose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4950 ) or ( META1_1862 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Transaldolase Phosphoglucose isomerase//Transaldolase ) or ( putative Transaldolase Phosphoglucose isomerase//Transaldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEH__45__RXN" name="Malate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1537_mdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: aspartate degradation II</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.37</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9819" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3008 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Naphthalene 1,2-dioxygenase subunit alpha (Naphthalene 1,2-dioxygenase ISP alpha) )</html:p>
<html:p>SUBSYSTEM: indigo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE" stoichiometry="1"/>
      <speciesReference species="NADH" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10523" stoichiometry="1"/>
      <speciesReference species="NADH" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9818" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: indigo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10523" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOXYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIMSYN1__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1503_thiC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Thiamine biosynthesis protein thiC )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNPOXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4936 ) or ( META1_0176 ) or ( META1_4692_pdxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyridoxamine 5&apos;-phosphate oxidase-related ) or ( putative pyridoxamine 5&apos;-phosphate oxidase-related ) or ( pyridoxine 5&apos;-phosphate oxidase//PMPOXI-RXN//PNPOXI-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__16__45__RXN" name="Serine/threonine specific protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META2_0397 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative serine/threonine protein phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.16</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__4" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4817 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative NAD binding site:Amine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3666 ) or ( META1_3135_guaA ) or ( META1_2517_hisH ) or ( META1_0546 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glutamine amidotransferase-like ) or ( GMP synthetase (glutamine aminotransferase)//GMP-SYN-GLUT-RXN ) or ( glutamine amidotransferase, subunit with HisF ) or ( putative Glutamine amidotransferase, class-I family protein (guaA-like) )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: guanosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.2</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0687 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amidase )</html:p>
<html:p>SUBSYSTEM: anandamide degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7598" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOATE__45__BETA__45__ALANINE__45__LIG__45__RXN" name="Pantoate--&amp;beta;-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2235_panC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pantoate--beta-alanine ligase (Pantothenate synthetase) (Pantoate-activating enzyme)//PANTOATE-BETA-ALANINE-LIG-RXN//Pantoate--beta-alanine ligase )</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FPPSYN__45__RXN" name="geranyltranstransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2496_ispA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranyltranstransferase (farnesyl-diphosphate synthase)//FPPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9666" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5221_ybgC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OLEOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2944_gck ) or ( META1_2748 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerate kinase ) or ( putative glycerate kinase )</html:p>
<html:p>SUBSYSTEM: D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTOLDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1961_hisD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional HisD: L-histidinal:NAD+ dehydrogenase ; L-histidinol:NAD+ dehydrogenase//HISTALDEHYD-RXN//HISTOLDEHYD-RXN )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBINAMIDEKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1336_cobP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Bifunctional adenosylcobalamin biosynthesis protein cobP )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.156</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R9__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4879 ) or ( META1_4632 ) or ( META1_3452 ) or ( META1_5098_croA ) or ( META1_3870 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase ) or ( putative enoyl-CoA hydratase/isomerase family protein ) or ( putative fatty acid oxidation complex subunit alpha (enoyl-CoA hydratase and epimerase and isomerase ; 3-hydroxyacyl-CoA dehydrogenase) (fadJ-like; synonym yfcX)//3-hydroxyacyl-CoA dehydrogenase ) or ( 3-hydroxybutyryl-CoA dehydratase ) or ( Enoyl-CoA hydratase/isomerase family protein//Enoyl-CoA hydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4888_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional folylpolyglutamate synthase and dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROGENASE__45__ACCEPTOR__45__RXN" name="Alcohol dehydrogenase (acceptor)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4535_mxaI ) or ( META1_4538_mxaF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Methanol dehydrogenase subunit 2 precursor (MDH small beta subunit) ) or ( Methanol dehydrogenase subunit 1 precursor (MDH large alpha subunit) (MEDH) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.8</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Primary__45__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD_TO_NADH_COF_RXN" name="NAD_TO_NADH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROGBIOSYN__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0556_gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase (NAD+)//GLYC3PDEHYDROGBIOSYN-RXN )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis I (plastid)</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis III</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.94</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FMNH2_TO_FMN_COF_RXN" name="FMNH2_TO_FMN_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FMNH2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHENYLTHFCYCLOHYDRO__45__RXN" name="Methenyltetrahydrofolate cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1729_fch )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methenyl tetrahydrofolate cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__PPENTOMUT__45__RXN" name="Phosphopentomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1808_deoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphopentomutase//D-PPENTOMUT-RXN//PPENTOMUT-RXN )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYLESTERASE__45__RXN" name="Carboxylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4191 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative hydrolase (carboxylesterase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Carboxylic__45__esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9671" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5085_mraY ) or ( META1_2015 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phospho-N-acetylmuramoyl-pentapeptide-transferase ) or ( putative glycosyl transferase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__UDP__45__NAcMur__45__Peptides__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="__124__NAcMur__45__Peptide__45__Undecaprenols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9672" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3147_murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase//NACGLCTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__NAcMur__45__Peptide__45__Undecaprenols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__NAcMur__45__Peptide__45__NAcGlc__45__Undecaprenols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9673" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3910_fadD ) or ( META2_0014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)//ACYLCOASYN-RXN ) or ( putative fatty-acid--CoA ligase (Acyl-CoA synthetase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__18" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__PHOSPHOGLUCOMUTASE__45__RXN" name="&amp;beta;-phosphoglucomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0381 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative beta-phosphoglucomutase )</html:p>
<html:p>SUBSYSTEM: trehalose degradation IV</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__448" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9674" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2480 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative Glycoside hydrolase, family 3, N-terminal and C-terminal domain (bglX-like) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10277" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10276" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OXALYL__45__COA__45__DECARBOXYLASE__45__RXN" name="Oxalyl-CoA decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0990 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative oxalyl-CoA decarboxylase (oxc, yfdU) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2PGADEHYDRAT__45__RXN" name="Phosphopyruvate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2984_eno )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enolase//2PGADEHYDRAT-RXN )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOKIN__45__RXN" name="Gluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3694_gntK ) or ( META1_1867_gntK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gluconokinase; gluconate transport, GNT I system//GLUCONOKIN-RXN ) or ( gluconate kinase 2 ; gluconate transport, GNT I system//GLUCONOKIN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMKALT__45__RXN" name="T2-induced deoxynucleotide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1978_gmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Guanylate kinase (GMP kinase)//GUANYL-KIN-RXN//Guanylate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDPHOS__45__RXN" name="Histidinol-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4121 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative L-histidinol-phosphate phosphatase (hisN) )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.15</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8972" name="UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5087_murE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase//UDP-NACMURALGLDAPLIG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Lysine__45__or__45__DAP__124__" stoichiometry="1"/>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__UDP__45__N__45__acetylmuramoyl__45__Tripeptide__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOLATEDEHYDRO__45__RXN" name="Glycolate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5244 ) or ( META1_3364_glcF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycolate oxidase subunit GlcE ) or ( glycolate oxidase iron-sulfur subunit )</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation II</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.14</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERSYN__45__RXN" name="CDP-diacylglycerol--serine O-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5192_pssA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine synthase (pssA-like) )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylethanolamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.8</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8973" name="UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5086_murF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
      <speciesReference species="__124__UDP__45__N__45__acetylmuramoyl__45__Tripeptide__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__UDP__45__NAcMur__45__Peptides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8976" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3147_murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase//NACGLCTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7695" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8975" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5085_mraY ) or ( META1_2015 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phospho-N-acetylmuramoyl-pentapeptide-transferase ) or ( putative glycosyl transferase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: CPD__45__9646</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C3" stoichiometry="1"/>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C4" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__88__45__RXN" name="Peptide deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1530_def ) or ( META1_4332_def )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptide deformylase ) or ( Peptide deformylase (PDF) (Polypeptide deformylase)//3.5.1.88-RXN//Peptide deformylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.88</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNDECARBOX__45__RXN" name="Ornithine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0770 ) or ( META1_2027 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine decarboxylase ) or ( putative ornithine/diaminopimelate PLP-dependent decarboxylase )</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__KIN__45__RXN" name="Glycerol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4455_glpK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol kinase )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.30</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRUVATE__45__REDUCTASE__45__RXN" name="Hydroxypyruvate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2748 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycerate kinase )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.81</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UNDECAPRENYL__45__DIPHOSPHATASE__45__RXN" name="Undecaprenyl-diphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2389_bacA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Undecaprenyl-diphosphatase (Undecaprenyl pyrophosphate phosphatase) (Bacitracin resistance protein)//UNDECAPRENYL-DIPHOSPHATASE-RXN//Undecaprenyl-diphosphatase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.27</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5323_ilvH ) or ( META1_5051 ) or ( META1_5321_ilvI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetolactate synthase III, small subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN ) or ( putative acetolactate synthase large subunit (ilvG) ) or ( acetolactate synthase III, large subunit//ACETOLACTSYN-RXN//ACETOOHBUTSYN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis I</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__16__45__RXN" name="Isoquinoline 1-oxidoreductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0103 ) or ( META1_4978 ) or ( META1_0102_iorA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative isoquinoline 1-oxidoreductase, beta subunit ) or ( oxidoreductase, 2Fe-2S subunit ) or ( isoquinoline 1-oxidoreductase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOQUINOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOQUINOLIN__45__12H__45__ONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLORAMPHENICOL__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Chloramphenicol O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0593 ) or ( META1_2894_vatD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative acetyltransferase ) or ( Streptogramin A acetyltransferase (Virginiamycin acetyltransferase D) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.28</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLORAMPHENICOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLORAMPHENICOL__45__3__45__ACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R621__45__RXN" name="Nitric oxide dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4119 ) or ( META1_3768_hmp ) or ( META1_0746_hmp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Iron-sulfur cluster-binding protein, putative ferredoxin oxidoreductase protein ) or ( bifunctional: nitric oxide dioxygenase (N-terminal); dihydropteridine reductase 2 (C-terminal)//R621-RXN ) or ( bifunctional: nitric oxide dioxygenase (N-terminal); dihydropteridine reductase 2 (C-terminal)//R621-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.17</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRIC__45__OXIDE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9820" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: indigo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOXYL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10525" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PMPOXI__45__RXN" name="Pyridoxamine-phosphate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4936 ) or ( META1_0176 ) or ( META1_4692_pdxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Pyridoxamine 5&apos;-phosphate oxidase-related ) or ( putative pyridoxamine 5&apos;-phosphate oxidase-related ) or ( pyridoxine 5&apos;-phosphate oxidase//PMPOXI-RXN//PNPOXI-RXN )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGTPTRIPHYDRO__45__RXN" name="Deoxyguanosinetriphosphate triphosphohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2596 ) or ( META1_3621_dgt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative deoxyguanosine triphosphate triphosphohydrolase ) or ( Deoxyguanosinetriphosphate triphosphohydrolase-like protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.5.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYGUANOSINE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERATE__45__DEHYDROGENASE__45__RXN" name="Glycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1727_hprA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hydroxypyruvate reductase, NAD(P)H-dependent. )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.29</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4890_trpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase alpha subunit//TRYPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: GAP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9644" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3910_fadD ) or ( META2_0014 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase)//ACYLCOASYN-RXN ) or ( putative fatty-acid--CoA ligase (Acyl-CoA synthetase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OLEOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R343__45__RXN" name="Cob(II)yrinic acid a,c-diamide reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1981 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative cob(II)yrinic acid a,c-diamide reductase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 1.16.8.1</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FMN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__689" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__694" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOINASE__45__RXN" name="Allantoinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4700_pyrC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dihydroorotase-like protein )</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate I (urea producing)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate II (ammonia producing)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.5</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ALLANTOIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPRODEHYDROG__45__RXN" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0211_putA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline dehydrogenase PutA//RXN-821 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__4__45__HYDROXY__45__PROLINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="R544__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__865" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__866" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8991" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0186_leuD ) or ( META1_4800_leuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Isopropylmalate dehydratase small subunit/isopropylmalate isomerase.//3-ISOPROPYLMALISOM-RXN//RXN-8991 ) or ( 3-isopropylmalate isomerase, subunit with LeuD//3-ISOPROPYLMALISOM-RXN//RXN-8991 )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9451" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8992" name="all-trans-octaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3319_ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octaprenyl diphosphate synthase//FARNESYLTRANSTRANSFERASE-RXN )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.11</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYSYN__45__RXN" name="phosphatidate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2069_cdsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diglyceride synthase//CDPDIGLYSYN-RXN )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis I (plastid)</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis III</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.41</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOKETOLASE__45__RXN" name="Phosphoketolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0387_xfp ) or ( META1_3806_xfp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase ) or ( D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__4__46__27__45__RXN" name="Methenyltetrahydromethanopterin cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1763_mch )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase) )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation VI (H4MPT pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.27</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHENYLTETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THMPT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2770_mauB ) or ( META1_2773_mauA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Methylamine dehydrogenase large subunit precursor (MADH) ) or ( Methylamine dehydrogenase small subunit precursor (MADH) )</html:p>
<html:p>SUBSYSTEM: methanol and methylamine oxidation to formaldehyde</html:p>
<html:p>PROTEIN_CLASS: 1.4.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOADEHYDROG__45__RXN" name="Acyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3728 ) or ( META1_3716 ) or ( META1_0922 ) or ( META1_3921 ) or ( META1_4494 ) or ( META1_5048_acd ) or ( META1_3554 ) or ( META1_3456_fadE ) or ( META1_0946 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase ) or ( putative acyl-CoA dehydrogenase ) or ( putative acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( putative acyl-CoA dehydrogenase ) or ( acyl-CoA dehydrogenase ) or ( Acyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__5__45__EPIMERASE__45__RXN" name="UDP-glucuronate 5&apos;-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3234_lspL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucuronate 5&apos;-epimerase (UDP-glucuronic acid epimerase)//UDP-glucuronate 5&apos;-epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__223" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALISOM__45__RXN" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0186_leuD ) or ( META1_4800_leuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Isopropylmalate dehydratase small subunit/isopropylmalate isomerase.//3-ISOPROPYLMALISOM-RXN//RXN-8991 ) or ( 3-isopropylmalate isomerase, subunit with LeuD//3-ISOPROPYLMALISOM-RXN//RXN-8991 )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9451" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R345__45__RXN" name="Adenosylcobyric acid synthase (glutamine-hydrolyzing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5174_cobQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cobyric acid synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__691" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERONE__45__KINASE__45__RXN" name="Glycerone kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_0796_dhaK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dihydroxyacetone kinase (Glycerone kinase)//Glycerone kinase )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: glycerol degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.29</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__34__45__RXN" name="6,7-dihydropteridine reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3768_hmp ) or ( META1_0746_hmp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional: nitric oxide dioxygenase (N-terminal); dihydropteridine reductase 2 (C-terminal)//R621-RXN ) or ( bifunctional: nitric oxide dioxygenase (N-terminal); dihydropteridine reductase 2 (C-terminal)//R621-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.34</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5678__45__TETRAHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_67__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCPDIESTER__45__RXN" name="Glycerophosphodiester phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4458 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative glycerophosphoryl diester phosphodiesterase )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.46</html:p>
<html:p>SIDE: __124__Alcohols__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycerophosphodiesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPNACETYLMURAMATEDEHYDROG__45__RXN" name="UDP-N-acetylmuramate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3150_murB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylenolpyruvoylglucosamine reductase//UDPNACETYLMURAMATEDEHYDROG-RXN )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.158</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMHYDR__45__RXN" name="Fumarate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1338_fumC ) or ( META1_2857_fumC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarase C//FUMHYDR-RXN ) or ( fumarase C//FUMHYDR-RXN )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETYL__45__COA__45__TRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3125_atoA ) or ( META1_3124_atoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA:acetoacetyl-CoA transferase, beta subunit ) or ( acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit )</html:p>
<html:p>SUBSYSTEM: acetoacetate degradation (to acetyl CoA)</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8998" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4452_uppS ) or ( META1_2070_uppS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) ) or ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9453" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9452" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8997" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4452_uppS ) or ( META1_2070_uppS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) ) or ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9454" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9453" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8999" name="di-trans-poly-cis-decaprenylcistransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4452_uppS ) or ( META1_2070_uppS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) ) or ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9452" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8994" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4452_uppS ) or ( META1_2070_uppS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) ) or ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9457" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9456" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8993" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4452_uppS ) or ( META1_2070_uppS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) ) or ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9457" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ANTHRANSYN__45__RXN" name="Anthranilate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5119_trpG ) or ( META1_5117_trpE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminodeoxychorismate synthase component II, Glutamine amido-transferase ) or ( anthranilate synthase component I//ANTHRANSYN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.27</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8996" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4452_uppS ) or ( META1_2070_uppS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) ) or ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9455" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9454" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__LYASE__45__RXN" name="Cystathionine &amp;beta;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4647_metC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-lyase, PLP-dependent (beta-cystathionase)//CYSTATHIONINE-BETA-LYASE-RXN )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYMALTOPHOSPHORYL__45__RXN" name="glycogen phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2008_glgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase//GLYCOPHOSPHORYL-RXN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8995" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4452_uppS ) or ( META1_2070_uppS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) ) or ( undecaprenyl pyrophosphate synthetase (di-trans,poly-cis-decaprenylcistransferase) )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9456" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9455" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4890_trpA ) or ( META1_0049_trpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase alpha subunit//TRYPSYN-RXN ) or ( tryptophan synthase, beta protein//RXN0-2382//TRYPSYN-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCYSDESULF__45__RXN" name="D-cysteine desulfhydrase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2360_dcyD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-cysteine desulfhydrase, PLP-dependent enzyme//D-cysteine desulfhydrase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMPKI__45__RXN" name="Cytidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2119_cmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine monophosphate (CMP) kinase//CMPKI-RXN )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__129__45__RXN" name="Peptidoglycan glycosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5088_ftsI ) or ( META1_5233_pbpC ) or ( META1_1283_pbpC ) or ( META1_0533 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Peptidoglycan glycosyltransferase (penicillin-binding protein)//Peptidoglycan glycosyltransferase ) or ( penicillin-binding protein ) or ( penicillin binding protein//RXN0-5405 ) or ( Penicillin-binding protein 1A )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.129</html:p>
<html:p>SIDE: UNDECAPRENYL__45__DIPHOSPHATE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7695" stoichiometry="1"/>
      <speciesReference species="__124__Peptidoglycans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="__124__Peptidoglycans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRS__45__RXN" name="phosphoribosylformylglycinamidine cyclo-ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2045_purM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylaminoimidazole synthetase (AIR synthetase)//AIRS-RXN )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROPRIBTRANS__45__RXN" name="Orotate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3406_pyrE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( orotate phosphoribosyltransferase (OPRT) (OPRTase)//OROPRIBTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__REDUCT__45__RXN" name="Sulfite reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4939 ) or ( META1_2233_cysI ) or ( META1_2232_cysJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative sulfite reductase (NADPH) ) or ( sulfite reductase, beta subunit, NADPH-dependent hemoprotein//SULFITE-REDUCT-RXN ) or ( sulfite reductase, alpha subunit (flavoprotein)//FMNREDUCT-RXN//SULFITE-REDUCT-RXN )</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9229" name="3-demethylubiquinone-9 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5206 ) or ( META1_0733 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-demethylubiquinone-9 3-methyltransferase ) or ( putative UbiG: ubiquinone biosynthesis O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-7 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9861" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9955" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PURIDYLTRANS__45__RXN" name="UTP--glucose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3486_galU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-1-phosphate uridylyltransferase//GLUC1PURIDYLTRANS-RXN )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>SUBSYSTEM: sucrose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45____45__COA__45__LIGASE__45__RXN" name="Malate--CoA ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_1730_mtkA ) or ( META1_1731_mtkB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Malate thiokinase, large subunit ) or ( Malate thiokinase, small subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__208" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FOLYLPOLYGLUTAMATESYNTH__45__RXN" name="folylpolyglutamate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4888_folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional folylpolyglutamate synthase and dihydrofolate synthase//DIHYDROFOLATESYNTH-RXN//FOLYLPOLYGLUTAMATESYNTH-RXN//FORMYLTHFGLUSYNTH-RXN//RXN0-2921 )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9628" name="Palmitoyl-CoA hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5221_ybgC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10267" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3617" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9629" name="Palmitoyl-CoA hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5221_ybgC ) or ( META1_2544_yciA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase ) or ( acyl-CoA thioester hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9965" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="ARACHIDIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDLIPOXN__45__RXN" name="Dihydrolipoamide dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4470 ) or ( META1_1542_lpd ) or ( META1_2990_lpd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative dihydrolipoamide dehydrogenase ) or ( dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes//1.8.1.4-RXN//RXN-7716//RXN-8629//RXN0-1132 ) or ( dihydrolipoamide dehydrogenase, E3 Component of Pyruvate dehydrogenase multienzyme complex//1.8.1.4-RXN//RXN-7716//RXN-8629//RXN0-1132 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9624" name="Acyl-CoA hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5221_ybgC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase )</html:p>
<html:p>SUBSYSTEM: stearate biosynthesis I (animals)</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="STEAROYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="STEARIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9626" name="Palmitoyl-CoA hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5221_ybgC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRADECANOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__7836" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9627" name="Palmitoyl-CoA hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5221_ybgC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LAUROYLCOA__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="DODECANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4282 ) or ( META1_5053 ) or ( META1_2707 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Putative branched-chain amino acid aminotransferase ) or ( putative branched-chain amino acid aminotransferase ) or ( putative branched-chain amino acid transferase (ilvE-like) )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__884" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_2713_ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-3-methylbut-2-enyl diphosphate reductase//ISPH2-RXN )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYLPHENOL__45__HYDROX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_4310_ubiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ubiquinone biosynthesis protein, putative 2-polyprenylphenol 6-hydroxylase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYLPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8380" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: sulfur reduction II (via polysulfide)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CPD__45__846</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S8" stoichiometry="1"/>
      <speciesReference species="CPD__45__846" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Polysulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMUR__45__ALA__45__LIG__45__RXN" name="UDP-N-acetylmuramate--alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_3148_murC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylmuramate--L-alanine ligase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__ACETYLMURAMOYL__45__ALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9237" name="3-demethylubiquinone-9 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( META1_5206 ) or ( META1_0733 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-demethylubiquinone-9 3-methyltransferase ) or ( putative UbiG: ubiquinone biosynthesis O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9873" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9958" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
