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<model id="META_metabolic_network_metabolic_network" name="NA">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
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  <species id="VOMILENINE" name="vomilenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DIHYDROXY__45__PHENYLALANINE" name="L-dopa" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBON__45__MONOXIDE" name="CO" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7420" name="hydroxy-&amp;beta;-zeacarotene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7422" name="&amp;alpha;-zeacarotene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GAMMA__45__GLUTAMYLCYSTEINE" name="L-&amp;gamma;-glutamylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7424" name="9&apos;-cis-neoxanthin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP" name="guanosine-5&apos;-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6964" name="pinosylvin monomethylether" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6963" name="dihydropinosylvin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6962" name="2,6-dihydroxynicotinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" name="an L-1-phosphatidyl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SEDOHEPTULOSE__45__7__45__P" name="D-sedoheptulose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_17__45__O__45__DEACETYLVINDOLINE" name="17-O-deacetylvindoline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__HYDROXY__45__ETCETERA__45__HYDROXYPROPIONYL__45__COA" name="4-hydroxy-3-methoxyphenyl-&amp;beta;-hydroxypropionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GALACTURONATE" name="D-galacturonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__882" name="1,6-anhMurNAc" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__881" name="MurNAc-6-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6971" name="GA15 (closed lactone form)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6972" name="o-succinylbenzoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7414" name="&amp;epsilon;-carotene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6975" name="GA7" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6974" name="GA37 (closed lactone form)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__3__45__DIHYDROXYPHENYL__45__PROPIONATE" name="3-(2,3-dihydroxyphenyl)propionate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7419" name="&amp;beta;-zeacarotene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNOSE" name="D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7418" name="coumarinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6976" name="4-coumaroyl-4&apos;-hydroxyphenyllactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7417" name="cis-coumarinic acid-&amp;beta;-D-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6979" name="caffeoyl-4&apos;-hydroxyphenyllactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6978" name="4-coumaroyl-3&apos;,4&apos;-dihydroxyphenyllactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" name="4-amino-4-deoxychorismate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__D__45__GLUCOSE" name="GDP-&amp;alpha;-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Glucosinolates__124__" name="a glucosinolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TOLUENECISDHDIOL" name="toluene-cis-1,2-dihydrodiol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="H" name="H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7400" name="ammelide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" name="6,7-dimethyl-8-(1-D-ribityl)lumazine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7409" name="&amp;beta;-cryptoxanthin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6948" name="&amp;beta;-amyrin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6947" name="demethylphylloquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7408" name="phytofluene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__15__45__BISPHOSPHATE" name="ribose-1,5-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SYRINGETIN" name="syringetin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__N__45__METHYLCOCLAURINE" name="S-N-methylcoclaurine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SINAPOYL__45__COA" name="sinapoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Cleaved__45__DNA__124__" name="Cleaved DNA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSE" name="&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6955" name="p-coumaroyltriacetic acid lactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6954" name="p-coumaroyltriacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRIMETHYLSULFONIUM" name="trimethyl sulfonium" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXYADIPYL__45__COA" name="3-hydroxyadipyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4619" name="cis-zeatin-9-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__10116" name="tuberculosinol diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__10117" name="tuberculosinol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8199" name="a mismatched DNA base pair" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8192" name="demethylsuberosin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8191" name="marmesin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__1__45__ARSENATE" name="ribose-1-arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROKAEMPFEROL__45__CMPD" name="dihydrokaempferol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__HYDROXYMUCONIC__45__SEMIALDEHYDE" name="4-hydroxymuconic semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5678__45__TETRAHYDROPTERIDINE" name="5,6,7,8-tetrahydropteridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4620" name="cis-zeatin-O-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4621" name="dihydrozeatin-9-N-glucoside-O-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4622" name="trans-zeatin-O-glucoside-7-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THREO__45__DS__45__ISO__45__CITRATE" name="D-isocitrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_16__45__HYDROXYTABERSONINE" name="16-hydroxytabersonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8186" name="umbelliferone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8184" name="chrysin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__METHYLANTHRANILOYL__45__COA" name="N-methylanthraniloyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8180" name="DNA with lesion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BENZOYL__45__ACETATE" name="benzoyl-acetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Hydroxyflavonones__124__" name="a hydroxyflavonone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="__124__L__45__1__45__phosphatidyl__45__inositols__124__" name="an L-1-phosphatidyl-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="COLUMBAMINE" name="columbamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Phospholipid__45__Olefinic__45__Fatty__45__Acids__124__" name="a phospholipid olefinic fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LATHYRINE" name="lathyrine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
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  <species id="LAUROYLCOA__45__CPD" name="lauroyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8098" name="cis-caffeate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8091" name="1-18:1-2-18:2-phosphatidylcholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYNUCLEOTIDESM" name="(deoxynucleotides)(m)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8092" name="1-18:1-2-18:3-phosphatidylcholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8090" name="1-18:3-2-18:2-phosphatidylcholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
</listOfSpecies>
<listOfReactions>
  <reaction id="AKBLIG__45__RXN" name="Glycine C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kbl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Kbl )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: threonine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.29</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYADENPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DeoD )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ilvC ) or ( ilvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( acetohydroxy acid isomeroreductase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__57__45__RXN" name="Dihydrochelirubine 12-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.57</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROCHELIRUBINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_12__45__HYDROXYDIHYDROCHELIRUBINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R547__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__868" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__869" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4662" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CKX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytokinin oxidase )</html:p>
<html:p>SUBSYSTEM: cytokinins degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.12</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__4482" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4661" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CKX2 ) or ( CKX3 ) or ( CKX1 ) or ( CKX4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( cytokinin oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.12</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4483" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9700" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isoflavone-7-O-&amp;beta;-glucoside 6\&quot;-O-malonyltransferase ) or ( isoflavone-7-O-&amp;beta;-glucoside 6\&quot;-O-malonyltransferase )</html:p>
<html:p>SUBSYSTEM: apigenin glycosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.115</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APIGENIN__45__7__45__O__45__BETA__45__D__45__GLUCOSIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10318" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AKPTHIOL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__299" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATE__45__TRANSAMINE__45__RXN" name="glutamate-prephenate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine and tyrosine biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis II</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis III</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.79</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__659" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9703" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cpal2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vernolic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10320" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9702" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GlyA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.42</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10303" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCEREDCHLOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tceA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrachloroethene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DICHLOROETHENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VINYL__45__CHLORIDE" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__9__45__RXN" name="Saccharopine dehydrogenase (NAD+, L-glutamate forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AASS ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-lysine-&amp;alpha;-ketoglutarate reductase subunit ) or ( lysine-ketoglutarate reductase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RHAMNULOKIN__45__RXN" name="Rhamnulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rhaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of fucose and rhamnose degradation</html:p>
<html:p>SUBSYSTEM: rhamnose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RHAMNULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RHAMNULOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUC__45__COA_TO_CO__45__A_COF_RXN" name="SUC-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GENTISATE__45__12__45__DIOXYGENASE__45__RXN" name="Gentisate 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gentisate 1,2-dioxygenase subunit )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__633" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1070" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9716" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isovitexin and isovitexin glycosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10347" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10348" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9718" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acoL and acoC and acoB and acoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetoin:DCPIP oxidoreductase &amp;alpha; subunit and acetoin:DCPIP oxidoreductase &amp;beta; subunit and dihydrolipoamide acetyltransferase subunit and dihydrolipoyl dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: acetoin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__14__45__RXN" name="Asparagine--oxo-acid aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: asparagine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.14</html:p>
<html:p>SIDE: __124__2__45__Oxo__45__Acids__124__</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
      <speciesReference species="_2__45__OXOSUCCINAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__79__45__RXN" name="Phthalyl amidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( none )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Phthalyl amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.79</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__PHTHALYLAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUBSTITUTED__45__AMINE" stoichiometry="1"/>
      <speciesReference species="PHTHALATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9710" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: nitrilotriacetate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10189" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTEROATESYNTH__45__RXN" name="Dihydropteroate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( folP ) or ( Y08611 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FolP ) or ( HPPK/DHPS subunit )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.15</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9715" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isovitexin and isovitexin glycosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVITEXIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10347" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9714" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isovitexin and isovitexin glycosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__D__45__XYLOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVITEXIN" stoichiometry="1"/>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="CPD__45__10349" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__12__46__1__45__RXN" name="Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( antC and antB and antA ) or ( andAd and andAc and andAb and andAa ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anthranilate dioxygenase oxygenase component large subunit and anthranilate dioxygenase reductase component and anthranilate dioxygenase oxygenase component small subunit ) or ( anthranilate dioxygenase oxygenase componentsmall subunit and anthranilate dioxygenase reductase component and anthranilate dioxygenase ferredoxin component and anthranilate dioxygenase oxygenase component large subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: anthranilate degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.1</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGANINE__45__KINASE__45__RXN" name="Sphinganine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LCB4 ) or ( LCB5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.91</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSOSE__45__2__45__DEHYDRATASE__45__RXN" name="Myo-inosose-2 dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myo-inosose-2 dehydratase )</html:p>
<html:p>SUBSYSTEM: myo-inositol degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.44</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__365" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1133" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__LACTALDEHYDE__45__DEHYDROGENASE__45__RXN" name="D-lactaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( methylglyoxal reductase subunit and methylglyoxal reductase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation VI</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.78</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__358" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4681" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CKX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytokinin oxidase )</html:p>
<html:p>SUBSYSTEM: cytokinins degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.12</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4208" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4483" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLN_TO_GLT_COF_RXN" name="GLN_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMYLOMALT__45__RXN" name="4-&amp;alpha;-glucanotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( malQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9726" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 5&amp;beta;-POR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cardenolide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROGESTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5962" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9725" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  LcANR1 ) or ( MtBAN ) or ( AtBAN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2,3-cis-flavanols biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__591" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7630" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9724" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MtBAN ) or ( AtBAN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2,3-cis-flavanols biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PELARGONIDIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10413" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9723" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MtBAN ) or ( AtBAN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2,3-cis-flavanols biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7090" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10411" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9722" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 3&amp;beta;-HSD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cardenolide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREGNENOLONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROGESTERONE" stoichiometry="1"/>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.184</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Galactosyl__45__12__45__diacyl__45__glycerols__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__10363" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="CPD__45__10364" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIMETHYLLYSINE__45__DIOXYGENASE__45__RXN" name="Trimethyllysine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Tmlhe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;epsilon;-N-trimethyllysine hydroxylase subunit )</html:p>
<html:p>SUBSYSTEM: L-carnitine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.8</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N6N6N6__45__TRIMETHYL__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__N6N6N6__45__TRIMETHYL__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9740" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH-dependent dimethylsulfide monooxygenase )</html:p>
<html:p>SUBSYSTEM: dimethylsulfide degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of dimethylsulfone degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7670" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7671" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINE__45__NUCLEOSIDASE__45__RXN" name="Uridine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rihA ) or ( rihC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ribonucleoside hydrolase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4281" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yghZ ) or ( dkgB ) or ( AKR1B1 ) or ( dkgA ) or ( CYP2E1 ) or ( yeaE ) or ( Cyp2e1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-glyceraldehyde 3-phosphate reductase ) or ( NA ) or ( NA ) or ( NA ) or ( cytochrome P450 2E1 ) or ( methylglyoxal reductase ) or ( cytochrome P450 2E1 )</html:p>
<html:p>SUBSYSTEM: acetone degradation I (to methylglyoxal)</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__HEXAPRENYLTRANSTRANSFERASE__45__RXN" name="all-trans-heptaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDSS2 and PDSS1 ) or ( sds1 ) or ( hepT and hepS ) or ( ispB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decaprenyl diphosphate synthase subunit 1 and decaprenyl diphosphate synthase subunit 2 ) or ( solanesyl diphosphate synthase ) or ( heptaprenyl diphosphate synthase component 1 and heptaprenyl diphosphate synthase component 2 ) or ( NA ) or ( solanesyl diphosphate synthase monomer )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: decaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: all trans undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: heptaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: dodecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: nonaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: tridecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.30</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__271__45__RXN" name="GDP-L-fucose synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GER1 ) or ( fcl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.271</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__PENTAPRENYLTRANSFERASE__45__RXN" name="all-trans-hexaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDSS2 and PDSS1 ) or ( sds1 ) or ( hepT and hepS ) or ( COQ1 ) or ( ispB ) or ( hexs-b and hexs-a ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decaprenyl diphosphate synthase subunit 1 and decaprenyl diphosphate synthase subunit 2 ) or ( solanesyl diphosphate synthase ) or ( heptaprenyl diphosphate synthase component 1 and heptaprenyl diphosphate synthase component 2 ) or ( hexaprenyl diphosphate synthase subunit ) or ( NA ) or ( hexaprenyl diphosphate synthase component A and hexaprenyl diphosphate synthase component B ) or ( solanesyl diphosphate synthase monomer )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: decaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: all trans undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: heptaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: dodecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: nonaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: tridecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.33</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__65__45__RXN" name="Salicylaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.65</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SALICYLALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__110" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SEPIAPTERIN__45__REDUCTASE__45__RXN" name="Sepiapterin reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SPR ) or ( CT0609 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sepiapterin reductase subunit ) or ( sepiapterin reductase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.153</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__374" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RR__45__BUTANEDIOL__45__DEHYDROGENASE__45__RXN" name="(R,R)-butanediol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( budC ) or ( budC ) or ( butA ) or ( BDH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetoin reductase subunit ) or ( acetoin reductase subunit ) or ( 2,3-butanediol dehydrogenase subunit ) or ( 2,3-butanediol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: butanediol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTANEDIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9739" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH-dependent dimethylsulfoxide reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: dimethylsulfoxide degradation</html:p>
<html:p>SUBSYSTEM: superpathway of dimethylsulfone degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DMSO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7670" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9735" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( msmD and msmC and msmB and msmA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methanesulfonate monooxygenase reductase component and methanesulfonate monooxygenase hydroxylase component &amp;beta; subunit and methanesulfonate monooxygenase ferredoxin component subunit and methanesulfonate monooxygenase hydroxylase component &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: methanesulfonate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3746" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__82__45__RXN" name="3-methylquercetin 7-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methylquercetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.82</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3457__45__TETRAHYDROXY__45__3__45__METHOXYFLAVONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_345__45__TRIHYDROXY__45__37__45__DIMETHOXYFLAVONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9736" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dmdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dimethylsulfoniopropionate degradation III (demethylation)</html:p>
<html:p>SUBSYSTEM: superpathway of dimethylsulfoniopropionate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: _5__45__METHYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
      <speciesReference species="SS__45__DIMETHYL__45__BETA__45__PROPIOTHETIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
      <speciesReference species="CPD__45__7672" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__19__46__3__45__RXN" name="Linoleoyl-CoA desaturase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYB5A and CYB5R3 and FADS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome b5 and NADH-cytochrome b5 reductase 3 and fatty acid desaturase 2 )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-linolenate biosynthesis II (animals)</html:p>
<html:p>PROTEIN_CLASS: 1.14.19.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__18" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__LINOLENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9731" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcaH2 and pcaG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protocatechuate 3,4-dioxygenase type II &amp;alpha; subunit and protocatechuate 3,4-dioxygenase type II &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: 4-sulfocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10418" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10419" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__GLU__45__AMINOTRANSFORASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rocD ) or (  ) or ( OAT ) or (  ) or ( CAR2 ) or ( OAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( ornithine aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II (from arginine)</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9733" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SLH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-sulfocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10420" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9732" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcaB2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-carboxymuconate lactonizing enzyme type 2 )</html:p>
<html:p>SUBSYSTEM: 4-sulfocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10419" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10420" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__OXOHEXANOATE__45__OXIDATION__45__RXN" name="6-oxohexanoate oxidation" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( chnE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cyclohexanol degradation</html:p>
<html:p>SUBSYSTEM: nylon-6 oligomer degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.63</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__OXO__45__HEXANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SOLDEHYD__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tsaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-sulfobenzyl alcohol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: 4-toluenesulfonate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__SULFOBENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__SULFOBENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__15__45__RXN" name="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.15</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="CPD__45__190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNITOL__45__2__45__DEHYDROGENASE__45__RXN" name="Mannitol 2-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mtlD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.67</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4621" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CKX2 ) or ( CKX1 ) or ( CKX3 ) or ( CKX1 ) or ( CKX4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( cytokinin oxidase ) or ( NA ) or ( cytokinin oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.12</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4209" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRENAL" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENDEHYD__45__RXN" name="Phenylacetaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( feaB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FeaB ) or ( phenylacetaldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: phenylethylamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of phenylethylamine degradation</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.39</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTACONYL__45__COA__45__DECARBOXYLASE__45__RXN" name="Glutaconyl-CoA decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gcdD and gcdB and gcdC and gcdA ) or ( gcdH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GcdA and GcdB and GcdC and GcdD ) or ( glutaryl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: glutamate degradation V (via hydroxyglutarate)</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.70</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__1__45__RXN" name="&amp;gamma;-butyrobetaine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( Bbox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-butyrobetaine hydroxylase subunit ) or ( &amp;gamma;-butyrobetaine hydroxylase subunit )</html:p>
<html:p>SUBSYSTEM: L-carnitine biosynthesis</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-butyrobetaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.1</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAMMA__45__BUTYROBETAINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROCOUMARIN__45__LIPASE__45__RXN" name="Dihydrocoumarin lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coumarin metabolism (to melilotic acid)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.35</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROCOUMARIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MELILOTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__262__45__RXN" name="4-hydroxythreonine-4-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdxA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.262</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STREPTOMYCIN__45__6__45__PHOSPHATASE__45__RXN" name="Streptomycin-6-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( strK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.39</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__529" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="STREPTOMYCIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PDXJ__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdxJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine 5&apos;-phosphate synthase monomer )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.6.99.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="_1__45__AMINO__45__PROPAN__45__2__45__ONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__5__46__1__46__13__45__RXN" name="ent-copalyl diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CPS1 ) or ( Cyc2 ) or ( CPS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( ent-copalyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of GA12 biosynthesis</html:p>
<html:p>SUBSYSTEM: ent-kaurene biosynthesis</html:p>
<html:p>SUBSYSTEM: diterpene phytoalexins precursors biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ENT__45__COPALYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVIN__45__SYN__45__RXN" name="Riboflavin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ribC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R11__45__RXN" name="Acetate CoA-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( cat3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glutamate degradation V (via hydroxyglutarate)</html:p>
<html:p>SUBSYSTEM: succinate fermentation to butyrate</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>SUBSYSTEM: gallate degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRIC_ACID" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOICASE__45__RXN" name="Allantoicase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( DAL2 ) or ( puuF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allantoicase subunit ) or ( allantoicase monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation in plants</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate I (urea producing)</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation in yeast</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate I</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AQUACOBALAMIN__45__REDUCTASE__45__RXN" name="Aquacobalamin reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fre )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.16.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1829" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AQUACOBIIIALAMIN" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCROSE__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="Sucrose-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sucrose phosphate synthase ) or ( NA ) or ( sucrose phosphate synthase )</html:p>
<html:p>SUBSYSTEM: sucrose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.14</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: FRUCTOSE__45__6P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCROSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Ubiquinones__124___TO___124__Ubiquinols__124___COF_RXN" name="|Ubiquinones|_TO_|Ubiquinols|_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Ubiquinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ubiquinols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4641" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CKX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytokinin oxidase )</html:p>
<html:p>SUBSYSTEM: cytokinins degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.12</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4207" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRENAL" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THI__45__P__45__KIN__45__RXN" name="Thiamine-phosphate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( thiL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamine monophosphate kinase )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.16</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PELUDP__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At5g17050 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.115</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PELARGONIDIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PELARGONIDIN__45__3__45__GLUCOSIDE__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERCAPYSTRANS__45__RXN" name="3-mercaptopyruvate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mpst ) or ( sseA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HSCN</html:p>
<html:p>SIDE: HCN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCN" stoichiometry="1"/>
      <speciesReference species="_3__45__MERCAPTO__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HSCN" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__137__45__RXN" name="Arsenite methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AS3MT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.137</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__763" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLARSONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__3__46__2__46__8__45__RXN" name="Limonene-1,2-epoxide hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( limA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (+)-(4R)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4R__45__Limonene__45__1__45__2__45__epoxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__56__45__RXN" name="Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bphB2 ) or ( bphB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cis-3-phenylcyclohexa-3,5-diene-1,2-diol dehydrogenase ) or ( cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: biphenyl degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.56</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__3__45__PHENYLCYCLOHEXA__45__35__45__DIENE__45__12__45__DIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIPHENYL__45__23__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R268__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( badI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BadI )</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__554" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__558" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7561" name="ornithine N-succinyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aruG and aruF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginine succinyltransferase &amp;beta; subunit and arginine succinyltransferase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.109</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__SUCCINYLORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7562" name="Acetylornithine aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aruC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinylornithine transaminase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.11</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINA1__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( linA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-hexachlorocyclohexane degradation</html:p>
<html:p>PROTEIN_CLASS: 4.5.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAMMA__45__HCH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__PENTACHLOROCYCLOHEXANE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RAUCAFFRICINE__45__BETA__45__GLUCOSIDASE__45__RXN" name="Raucaffricine &amp;beta;-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.125</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RAUCAFFRICINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="VOMILENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__ARABINOSE__45__4__45__EPIMERASE__45__RXN" name="UDP-arabinose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( MUR4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-L-arabinose biosynthesis I (from UDP-xylose)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__L__45__ARABINOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYBENZALDEHYDE__45__OXIDATION__45__NADP__45__RXN" name="Benzaldehyde dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdlD ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXYBENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP__45__4__45__DEHYDRO__45__D__45__RHAMNOSE__45__REDUCTASE__45__RXN" name="GDP-4-dehydro-D-rhamnose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rmd ) or ( rmd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: GDP-D-rhamnose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.187</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__353" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7541" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: willardiine and isowillardiine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.53</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: ACETYLSERINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__URACIL__45__1__45__YL__45__L__45__SERINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7543" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: willardiine and isowillardiine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.53</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: ACETYLSERINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="ISOWILLARDIINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANDELONITRILE__45__LYASE__45__RXN" name="Mandelonitrile lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MDL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: amygdalin and prunasin degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.10</html:p>
<html:p>SIDE: BENZALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANDELONITRILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
      <speciesReference species="HCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTONDEHYDRAT__45__RXN" name="Galactonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dgoD ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: D-galactonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GALACTONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPSYN__45__RXN" name="Tryptophan synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( trpB and trpA ) or ( trpB and trpA ) or ( trpA and trpB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase, &amp;beta; subunit and tryptophan synthase, &amp;alpha; subunit ) or ( tryptophan synthase &amp;beta; subunit and tryptophan synthase subunit &amp;alpha; ) or ( &amp;beta; subunit of tryptophan synthase and &amp;alpha; subunit of tryptophan synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLY3KIN__45__RXN" name="Glycerate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glxK ) or ( GLYK ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerate kinase II ) or ( NA ) or ( glycerate kinase )</html:p>
<html:p>SUBSYSTEM: photorespiration</html:p>
<html:p>SUBSYSTEM: superpathway of glycol metabolism and degradation</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.31</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FESGSHTHIO__45__RXN" name="Sulfur dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione-dependent sulfur dioxygenase subunit ) or ( glutathione-dependent sulfur dioxygenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfide oxidation (Starkeya novella)</html:p>
<html:p>SUBSYSTEM: sulfur oxidation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfide oxidation (Acidithiobacillus ferrooxidans)</html:p>
<html:p>SUBSYSTEM: sulfide oxidation IV (sulfur dioxygenase)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.18</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Thiols__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Perthiols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Thiols__124__" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CINNAMATE__45__GLUCOSYLTRANSFERASE__45__RXN" name="Cinnamate glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( UGT84B1 ) or ( FaGT2 ) or ( AOG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cinnamate esters biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.177</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__674" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__CINNAMOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEHYDROPANTLACRED__45__RXN" name="2-dehydropantolactone reductase (B-specific)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.214</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOYL__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDROPANTOYL__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYRAMINE__45__N__45__FERULOYLTRANSFERASE__45__RXN" name="Tyramine N-feruloyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( THT ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyramine hydroxycinnamoyltransferase ) or ( tyramine N-hydroxycinnamoyltransferase ) or ( NA ) or ( tyramine N-hydroxycinnamoyltransferase )</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid tyramine amides biosynthesis</html:p>
<html:p>SUBSYSTEM: suberin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.110</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYRAMINE" stoichiometry="1"/>
      <speciesReference species="FERULOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__440" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DETHIOBIOTIN__45__SYN__45__RXN" name="dethiobiotin synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bioD ) or ( bioD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dethiobiotin synthetase subunit ) or ( dethiobiotin synthetase monomer )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis III</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5398" name="Pseudouridylate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( yeiN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pseudoeuridine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.-.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACSERLY__45__RXN" name="Cysteine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( oasA1 ) or ( cysM ) or ( oasC ) or ( oasB ) or ( cysK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-acetylserine (thiol) lyase ) or ( CysM ) or ( O-acetylserine (thiol) lyase ) or ( O-acetylserine (thiol) lyase ) or ( CysK )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.47</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2482" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahAa and nahAb and nahAd and nahAc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha; subunit of naphthalene 1,2-dioxygenase terminal oxygenase and naphthalene 1,2-dioxygenase terminal oxygenase &amp;beta; subunit and naphthalene 1,2-dioxygenase component A and naphthalene 1,2-dioxygenase component C )</html:p>
<html:p>SUBSYSTEM: fluorene degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FLUORENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__4DH3__45__4DHFLUORENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__8__46__1__46__8__45__RXN" name="Atrazine chlorohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trzN ) or ( trzN ) or ( atzA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triazine hydrolase subunit ) or ( NA ) or ( AtzA )</html:p>
<html:p>SUBSYSTEM: atrazine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: atrazine degradation III</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATRAZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYATRAZINE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__O__45__ACETTRAN__45__RXN" name="Serine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SAT52 ) or ( SAT1-a ) or ( SAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine acetyltransferase monomer ) or ( serine acetyltransferase ) or ( serine acetyltransferase ) or ( serine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.30</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDINE__45__AMMONIA__45__LYASE__45__RXN" name="Histidine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HAL ) or ( hutH ) or ( hutH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidase subunit ) or ( histidase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: histidine degradation I</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>SUBSYSTEM: histidine degradation VI</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROCANATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__28__45__RXN" name="Tryptophan--phenylpyruvate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase II )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VIII (to tryptophol)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.28</html:p>
<html:p>SIDE: PHE</html:p>
<html:p>SIDE: PHENYL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__140__45__RXN" name="(S)-coclaurine-N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AB061863 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( coclaurine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: (S)-reticuline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.140</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__COCLAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__N__45__METHYLCOCLAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__121__45__RXN" name="Phosphoenolpyruvate--glycerone phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dhaM and dhaK and dhaL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxyacetone kinase subunit K and dihydroxyacetone kinase subunit M and dihydroxyacetone kinase subunit L )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.121</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCLOARTENOL__45__SYNTHASE__45__RXN" name="Cycloartenol synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RcCAS ) or ( KcCAS ) or ( OSCPNX1 ) or ( ACX ) or ( cs1 ) or ( CAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( cycloartenol synthase )</html:p>
<html:p>SUBSYSTEM: ginsenoside biosynthesis</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mangrove triterpenoid biosynthesis</html:p>
<html:p>SUBSYSTEM: avenacin biosynthesis</html:p>
<html:p>SUBSYSTEM: diploterol and cycloartenol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYCLOARTENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONDEHYDROG__45__RXN" name="Phosphogluconate dehydrogenase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gndA ) or ( gnd ) or ( gnd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( Gnd ) or ( 6-phosphogluconate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANINE__45__DEAMINASE__45__RXN" name="Guanine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( guaD ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5375" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( azoR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH-azoreductase, FMN-dependent )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.6</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1147" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1148" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2SOXIREDPYRO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( sreC and sreB and sreA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 72 kDa subunit and hydrogenase subunit and 50 kDa subunit and sulfur reductase subunit and cytochrome b subunit and cytochrome c subunit and cytochrome b subunit and 82 kDa subunit and 24 kDa subunit ) or ( sulfur reductase FeS subunit and sulfur reductase membrane anchor and sulfur reductase molybdopterin subunit )</html:p>
<html:p>SUBSYSTEM: sulfur reduction I</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.3</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="S8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOSE__45__DEHYDRO__45__RXN" name="Glucoside 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lactose degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.13</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOLACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__82__45__RXN" name="Galactinol--sucrose galactosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( RFS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: stachyose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.82</html:p>
<html:p>SIDE: SUCROSE</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__1099" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URATE__45__OXIDASE__45__RXN" name="Urate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( puuD ) or ( URnod-35 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( uricase )</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: urate degradation to allantoin</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>PROTEIN_CLASS: 1.7.3.3</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__HYDROXYISOURATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__1__46__43__45__RXN" name="2-dehydro-3-deoxy-L-arabinonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( araD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-2-keto-3-deoxyarabonate dehydratase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.43</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1134" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__654" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lpxT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein with low undecaprenyl pyrophosphate phosphatase activity )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__939" stoichiometry="1"/>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1151" stoichiometry="1"/>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMACETOXID__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tynA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TynA )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.21</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__35528" name="Aralkylamine N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aanat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aralkylamine N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: serotonin and melatonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.87</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SEROTONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__SEROTONIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5387" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ytfG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P)H:quinone oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1156" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1157" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( ligC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of 2-hydroxy-4-carboxymuconate semialdehyde dehydrogenase ) or ( LigC )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation I (meta-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2542" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__184" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3283" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formate hydrogenlyase complex iron-sulfur protein and hydrogenase 3, large subunit and hydrogenase 3, membrane subunit and hydrogenase 3, Fe-S subunit and hydrogenase 3, membrane subunit and hydrogenase 3 and formate hydrogenlyase complex, HycG subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="E__45__" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( pmdD ) or ( ligI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 2-pyrone-4,6-dicarboxylate hydrolase ) or ( 2-pyrone-4,6-dicarboxylate hydrolase )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation I (meta-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.57</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__184" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__OXALOMESACONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUGAR__45__TERMINAL__45__PHOSPHATASE__45__RXN" name="Sugar-terminal-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yfbT ) or ( ybiV ) or ( yigL ) or ( yidA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sugar phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.58</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__ISOPROPYLMALATESYN__45__RXN" name="2-isopropylmalate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( leuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-isopropylmalate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.13</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2463" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( ligJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of 4-oxalomesaconate hydratase ) or ( subunit of 4-oxalomesaconate hydratase )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation I (meta-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__OXALOMESACONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__OXALOCITRAMALATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2464" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( proK ) or (  ) or ( ligK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of 4-oxalocitramalate aldolase ) or ( subunit of 4-hydroxy-4-methyl-2-oxoglutarate aldolase ) or ( LigK )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation I (meta-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.17</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__OXALOCITRAMALATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5284" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acsF ) or ( CHL27 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_131__45__OXO__45__MAGNESIUM__45__PROTOPORPHYRIN__45__IX__45__13__45__M" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIVINYL__45__PROTOCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acsF ) or ( CHL27 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_13__45__HYDROXY__45__MAGNESIUM__45__PROTOPORP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_131__45__OXO__45__MAGNESIUM__45__PROTOPORPHYRIN__45__IX__45__13__45__M" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__328" name="ceramide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LAC1 ) or ( LAG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Aldehydes__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Phytoceramides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acsF ) or ( CHL27 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MG__45__PROTOPORPHYRIN__45__MONOMETHYL__45__ESTER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_13__45__HYDROXY__45__MAGNESIUM__45__PROTOPORP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5393" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fadB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dodecenoyl-CoA &amp;delta;-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: oleate &amp;beta;-oxidation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1162" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1163" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5395" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ygjK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycoside hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__BETA__45__D__45__GLUCOSYLGLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="BACOAHYDRO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( baiF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BaiF )</html:p>
<html:p>SUBSYSTEM: cholate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.26</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCHOLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="DEOXYCHOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5391" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fadB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dodecenoyl-CoA &amp;delta;-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: oleate &amp;beta;-oxidation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1162" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1158" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5390" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ybaW )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thioesterase III )</html:p>
<html:p>SUBSYSTEM: oleate &amp;beta;-oxidation</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1159" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5359" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yeaP ) or ( ycdT ) or ( yddV ) or ( ydeH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diguanylate cyclase ) or ( diguanylate cyclase ) or ( diguanylate cyclase ) or ( diguanylate cyclase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.65</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C__45__DI__45__GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETHYLBILANESYN__45__RXN" name="Hydroxymethylbilane synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HEMC ) or ( hemC ) or ( hemC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( porphobilinogen deaminase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.61</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BADEL4OXRED__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bile acid &amp;Delta;4-oxidoreductase )</html:p>
<html:p>SUBSYSTEM: cholate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OXO__45__DELTA4__45__DEOXYCHOLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXO__45__DEOXYCHOLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__32__45__RXN" name="Aminomuconate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( amnC ) or (  ) or ( nbaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-aminomucoate semialdehyde dehydrogenase subunit ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: nitrobenzene degradation I</html:p>
<html:p>SUBSYSTEM: 2-amino-3-carboxymuconate semialdehyde degradation to 2-oxopentenoate</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation I</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.32</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINOMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__MUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__157__45__RXN" name="Glucosamine-1-phosphate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glmU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GlmU )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.157</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCOSAMINE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINOALANINE__45__AMINOTRANSFERASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Got1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.1</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLESTANETETRAOL__45__26__45__DEHYDROGENASE__45__RXN" name="Cholestanetetraol 26-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdxr and Cyp27a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 27A1 and NA )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.161</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__BETA__45__CHOLESTANE__45__3__45__ALPHA7__45__TETRAOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__ALPHA7__45__ALPHA12__45__ALPHA__45__TRIHYDROX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__AMINOVALERATE__45__AMINOTRANSFERASE__45__RXN" name="5-aminovalerate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( davT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.48</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINOPENTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__280" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__19__45__RXN" name="3-phosphoshikimate 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aroA ) or ( aroE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.19</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__44__45__RXN" name="Glucuronate-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( USP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-glucuronate biosynthesis (from myo-inositol)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.44</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__510" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5363" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lacZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-galactosidase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLOLACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5364" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lhgO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-2-hydroxyglutarate oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXYGLUTARIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__83__45__RXN" name="D-malate dehydrogenase (decarboxylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yeaU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-malate dehydrogenase (decarboxylating) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.83</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__660" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TECH2REDHAL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PcpC )</html:p>
<html:p>SUBSYSTEM: pentachlorophenol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>SIDE: OXIDIZED__45__GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_236__45__TRICHLOROHYDROQUINONE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="_26__45__DICHLORO__45__P__45__HYDROQUINONE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALOX__45__RXN" name="Malate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYOSCYAMINE__45__6__45__DIOXYGENASE__45__RXN" name="Hyoscyamine (6S)-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( H6H )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hyoscyamine and scopolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.11</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__HYOSCYAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__99__45__RXN" name="16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vindoline and vinblastine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.99</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_16__45__METHOXY__45__23__45__DIHYDRO__45__3__45__HYDROXYTABERSON" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEACETOXYVINDOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCROSE__45__PHOSPHATASE__45__RXN" name="Sucrose-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sucrose-6F-phosphate phosphohydrolase )</html:p>
<html:p>SUBSYSTEM: sucrose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.24</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__2__46__14__45__RXN" name="N-methylhydantoinase (ATP-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-methylhydantoin amidohydrolase &amp;alpha; subunit and N-methylhydantoin amidohydrolase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: creatinine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__METHYLHYDANTOIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R542__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( camD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__863" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__864" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ECDYSONE__45__20__45__MONOOXYGENASE__45__RXN" name="Ecdysone 20-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cytochrome P450 314a1, mitochondrial )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.22</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ECDYSONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__276" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMYGDALIN__45__BETA__45__GLUCOSIDASE__45__RXN" name="Amygdalin &amp;beta;-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: amygdalin and prunasin degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.117</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1125" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__553" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYCEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Diacylglycerol O-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( WS1 ) or ( TAG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( diacylglycerol acyltransferase )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: wax esters biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.20</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( waaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: KDO transfer to lipid IVA</html:p>
<html:p>PROTEIN_CLASS: 2.-.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LIPID__45__IV__45__A" stoichiometry="1"/>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO__45__LIPID__45__IVA" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2541" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPT1 ) or ( slr1736 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: vitamin E biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PHYTYL__45__PYROPHOSPHATE</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTYL__45__PYROPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MPBQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2543" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTE1 ) or ( slr1737 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tocopherol cyclase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: vitamin E biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DMPBQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMA__45__TOCOPHEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__1__46__101__45__RXN" name="Trans-feruloyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCHL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: capsaicin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.101</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FERULOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXY__45__ETCETERA__45__HYDROXYPROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2542" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTE3 ) or ( sll0418 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: vitamin E biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MPBQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DMPBQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__2__46__17__45__RXN" name="Hydroxyisourate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G58220 ) or ( HIUHase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( OHCU decarboxylase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: urate degradation to allantoin</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__HYDROXYISOURATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5821" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__5__46__1__45__RXN" name="Nitrilase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( merR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrilase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nitriles__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDDEHYDROG__45__RXN" name="Lactaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aldA ) or ( MJ1411 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AldA ) or ( lactaldehyde dehydrogenase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lactate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: L-lactaldehyde degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of fucose and rhamnose degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation IV</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation V</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-D-GLUCOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__OXIDASE__45__RXN" name="Nucleoside oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleotide oxidase &amp;beta; subunit and nucleotide oxidase &amp;gamma; subunit and nucleotide oxidase &amp;delta; subunit and nucleotide oxidase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7102" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__XYLULOSE__45__REDUCTASE__45__RXN" name="L-xylulose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( lxr1 ) or ( DCXR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-xylulose reductase subunit ) or ( NA ) or ( L-xylulose reductase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation II</html:p>
<html:p>SUBSYSTEM: glucuronate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.10</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSIDE__45__3__45__DEHYDROGENASE__45__RXN" name="Glucoside 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sucrose degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.13</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__384" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__99__46__17__45__RXN" name="Squalene--hopene cyclase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: diploterol and cycloartenol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOP__45__2229__45__ENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R223__45__RXN" name="long-chain-fatty-acid-CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( alkK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: octane oxidation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__196" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R101__45__RXN" name="Diaminobutyrate--pyruvate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dat ) or ( ectB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-2,4-diaminobutyrate:2-ketoglutaraye 4-aminotransferase subunit ) or ( EctB )</html:p>
<html:p>SUBSYSTEM: ectoine biosynthesis</html:p>
<html:p>SUBSYSTEM: rhizobactin 1021 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.46</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__470" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6081" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCARDEHYDRA__45__RXN" name="Glucarate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gudD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-glucarate dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.40</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__KETO__45__4__45__DEOXY__45__D__45__GLUCARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1082" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gctA and gctB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GctA and GctB )</html:p>
<html:p>SUBSYSTEM: glutamate degradation V (via hydroxyglutarate)</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.12</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="R__45__2__45__HYDROXYGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXYGLUTARYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1083" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hgdA and hgdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( HgdB and HgdA )</html:p>
<html:p>SUBSYSTEM: glutamate degradation V (via hydroxyglutarate)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXYGLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8209" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: ternatin C5 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7870" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7864" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5329" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nanM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylneuraminate mutarotase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1122" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1123" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOVALERYL__45__COA__45__FAD__45__RXN" name="Isovaleryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acdH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8204" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PfAT208 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: shisonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: P__45__COUMAROYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__766" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7866" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8201" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vindoline and vinblastine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD__45__7859</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VINDOLINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__7859" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7858" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8202" name="thiosulfate--thiol sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FMP31 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur metabolism (Desulfocapsa sulfoexigens)</html:p>
<html:p>SUBSYSTEM: thiosulfate disproportionation I (thiol-dependent)</html:p>
<html:p>SUBSYSTEM: superpathway of thiosulfate metabolism (Desulfovibrio sulfodismutans)</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.3</html:p>
<html:p>SIDE: __124__Thiols__124__</html:p>
<html:p>SIDE: __124__Disulfides__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Thiols__124__" stoichiometry="2"/>
      <speciesReference species="S2O3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Disulfides__124__" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8208" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: ternatin C5 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.238</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7862" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7870" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8205" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HGT8 ) or ( PF3R4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: shisonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7866" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7714" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8206" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: ternatin C5 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.171</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7117" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7862" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FADSYN__45__RXN" name="FMN adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ribF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional riboflavin kinase / FMN adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.2</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NP ) or (  ) or ( deoD ) or ( deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase subunit ) or ( NA ) or ( DeoD ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITRATE__45____45__COA__45__LIGASE__45__RXN" name="Citrate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ccsB and ccsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( citryl-CoA synthetase large subunit and citryl-CoA synthetase small subunit )</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle II</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.18</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3S__45__CITRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1065" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_910__45__EPOXY__45__18__45__HYDROXYSTEARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_91018__45__TRIHYDROXYSTEARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1064" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.11.-.-</html:p>
<html:p>SIDE: __124__Alcohols__124__</html:p>
<html:p>SIDE: A__45__LIPID__45__HYDROPEROXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__LIPID__45__HYDROPEROXIDE" stoichiometry="1"/>
      <speciesReference species="_18__45__HYDROXYOLEATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="_910__45__EPOXY__45__18__45__HYDROXYSTEARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1063" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( CYP86A8 ) or ( CYP94C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( fatty acid &amp;omega;-hydroxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: suberin biosynthesis</html:p>
<html:p>SUBSYSTEM: cutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_18__45__HYDROXYOLEATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5242" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-4 ) or ( KO1 ) or ( KO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ent-kaurene oxidase ) or ( ent-kaurene oxidase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>SUBSYSTEM: superpathway of GA12 biosynthesis</html:p>
<html:p>SUBSYSTEM: GA12 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.78</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ENT__45__KAUR__45__16__45__EN__45__19__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ENT__45__KAUR__45__16__45__EN__45__19__45__AL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBDEHYDROG__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH4A1 ) or ( putA ) or ( rocA ) or ( put2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;-1-pyrroline-5-carboxylate dehydrogenase subunit ) or ( fused PutA transcriptional repressor / proline dehydrogenase / pyrroline-5-carboxylate dehydrogenase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade13 ) or ( purB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ade13 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_34__45__DIHYDROXYPHTHALATE__45__DECARBOXYLASE__45__RXN" name="3,4-dihydroxyphthalate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( padC2 ) or ( padC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,4-dihydroxyphthalate decarboxylase ) or ( 3,4-dihydroxyphthalate decarboxylase )</html:p>
<html:p>SUBSYSTEM: phthalate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.69</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__635" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEAM__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-cysteine desulfhydrase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDXANAU__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloroacetaldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: 1,2-dichloroethane degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.-.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLOROACETIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CAFFEOYL__45__COA__45__O__45__METHYLTRANSFERASE__45__RXN" name="Caffeoyl-CoA O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CCoAOMT ) or (  ) or ( CCoAOMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>SUBSYSTEM: capsaicin biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: suberin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.104</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CAFFEOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FERULOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__181__45__RXN" name="Cholest-5-ene-3-&amp;beta;,7-&amp;alpha;-diol 3-&amp;beta;-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd3b7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&amp;beta;-hydroxy-&amp;Delta;5-C27 steroid oxidoreductase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.181</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__266" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1087" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8232" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pGAT4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gentiodelphin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CAFFEOYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CAFFEOYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7966" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7963" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7591" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox1 ) or ( GA20ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 20-oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis II (early C-3 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6201" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__137" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8233" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pGAT4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gentiodelphin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.153</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CAFFEOYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CAFFEOYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7139" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7960" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7590" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis II (early C-3 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6202" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6201" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANDELATE__45__DEHYDROGENASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdlB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: mandelate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.31</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__122" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__141" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8231" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 3&apos;GT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gentiodelphin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.238</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7139" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7966" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7594" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: histidine degradation VI</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__OXOGLUTARAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7593" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: histidine degradation VI</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="_4__45__OXOGLUTARAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7592" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: histidine degradation VI</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__ISOGLUTAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="ISOGLUTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7587" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: histidine degradation VI</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__ISOGLUTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8228" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PF3R4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gentiodelphin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7117" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7139" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7585" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.17.3.3</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__HYDROXY__45__NICOTINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6962" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8226" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sor )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfur oxygenase reductase monomer )</html:p>
<html:p>SUBSYSTEM: sulfur disproportionation II (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur oxidation (Acidianus ambivalens)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S8" stoichiometry="5"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="S2O3" stoichiometry="1"/>
      <speciesReference species="HS" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rbsD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose pyranase )</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1110" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8225" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_16__45__EPIVELLOSIMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VELLOSIMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2502" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DDF dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: fluorene degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_110__45__DIHYDRO__45__110__45__DIHYDROXYFLUOREN__45__9__45__ONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__2__45__CARBOXYPHENYLCATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7589" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox1 ) or ( GA20ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 20-oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis II (early C-3 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6228" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTPPYPHOSKIN__45__RXN" name="GTP diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( relA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__TP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLOROCATDIOXY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( chlorocatechol 1,2-dioxygenase )</html:p>
<html:p>SUBSYSTEM: 1,4-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_36__45__DICHLOROCATECHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_25__45__DICHLORO__45__CISCIS__45__MUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5306" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rhaM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-rhamnose mutarotase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RHAMNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1112" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLMALONYL__45__COA__45__EPIM__45__RXN" name="Methylmalonyl-CoA epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Msed_0639 ) or (  ) or (  ) or ( GI:18042134 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( methylmalonyl-CoA racemase subunit ) or ( methylmalonyl CoA epimerase subunit )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: 2-oxobutanoate degradation I</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: glutamate degradation VIII (to propionate)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate cycle</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZOQ__45__OH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__OH__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIGLUCODIACETYL__45__DOCOSANOATE__45__LYSIS__45__RXN" name="acetic-ester acetylhydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sophorosyloxydocosanoate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIGLUCODIACETYL__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="DIGLUCOACETYL__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSPAMID__45__RXN" name="glutathionylspermidine amidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( gspS ) or ( TryS ) or ( gsp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( Gsp )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.78</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONYLSPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8220" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AAE ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_17__45__O__45__ACETYLNORAJMALINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4241" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8222" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AAE ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7956" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4242" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE__45__OXID__45__RXN" name="L-aspartate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At5g14760 ) or ( nadB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMINOASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCLOPENTANOL__45__DEHYDROGENASE__45__RXN" name="Cyclopentanol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cpnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyclopentanol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.163</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYCLOPENTANOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYCLOPENTANONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLSULFAT__45__RXN" name="Arylsulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aslA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Sulfate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8217" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( crtS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7953" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7952" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7596" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CmXRS1 ) or ( CaXMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-methylxanthosine synthase ) or ( 7-methylxanthosine synthase )</html:p>
<html:p>SUBSYSTEM: caffeine biosynthesis II (via paraxanthine)</html:p>
<html:p>SUBSYSTEM: caffeine biosynthesis I</html:p>
<html:p>SUBSYSTEM: theobromine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.158</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__METHYLXANTHOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7597" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-methyl nucleosidase )</html:p>
<html:p>SUBSYSTEM: caffeine biosynthesis II (via paraxanthine)</html:p>
<html:p>SUBSYSTEM: caffeine biosynthesis I</html:p>
<html:p>SUBSYSTEM: theobromine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_7__45__METHYLXANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="_7__45__METHYLXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7598" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( TCS1 ) or ( CaMXMT1 ) or ( CaMXMT2 ) or ( CCS1 ) or ( CaDXMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( caffeine synthase ) or ( caffeine synthase ) or ( theobromine synthase ) or ( theobromine synthase ) or ( caffeine synthase ) or ( caffeine synthase )</html:p>
<html:p>SUBSYSTEM: caffeine biosynthesis I</html:p>
<html:p>SUBSYSTEM: theobromine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.159</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_7__45__METHYLXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__7__45__DIMETHYLXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8218" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( crtS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7952" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7951" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7599" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( TCS1 ) or ( CCS1 ) or ( CaDXMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( caffeine synthase ) or ( caffeine synthase ) or ( caffeine synthase ) or ( caffeine synthase )</html:p>
<html:p>SUBSYSTEM: caffeine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.160</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__7__45__DIMETHYLXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__3__45__7__45__TRIMETHYLXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8212" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dsrN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( siroamide synthase subunit )</html:p>
<html:p>SUBSYSTEM: siroheme amide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7907" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8215" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: astaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7860" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7849" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8214" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: astaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7850" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7860" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPCARBOX__45__RXN" name="Phosphoenolpyruvate carboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pep1 ) or ( ppcA ) or (  ) or ( ppc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoenolpyruvate carboxylase ) or ( phosphoenolpyruvate carboxylase subunit ) or ( NA ) or ( Ppc )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: CO2 fixation into oxaloacetate</html:p>
<html:p>SUBSYSTEM: C4 photosynthetic carbon assimilation cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.31</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__REDUCT__45__RXN" name="GMP reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( guaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GuaC )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCHORSYN__45__RXN" name="Isochorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( entC ) or ( ICS ) or (  ) or ( dhbC ) or ( menF ) or ( ICS1 ) or ( menF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isochorismate synthase 1 ) or ( NA ) or ( NA ) or ( NA ) or ( MenF ) or ( NA ) or ( isochorismate synthase monomer )</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis II (plants)</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: salicylate biosynthesis</html:p>
<html:p>SUBSYSTEM: 2,3-dihydroxybenzoate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: bacillibactin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: enterobactin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.4.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOCHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7573" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__HYDROXY__45__NICOTINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__5__45__DIHYDROXYPYRIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7572" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ldha )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lactate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: histidine degradation V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMIDAZOLE__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7571" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidine-pyruvate aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: histidine degradation V</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.58</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7570" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bas1 ) or ( BgbAS ) or ( OSCPNY1 ) or ( KcMS ) or ( bAS1 ) or ( AvbAS1 ) or ( LUP2 ) or ( RsM2 ) or ( RsM1 ) or ( LUP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ginsenoside biosynthesis</html:p>
<html:p>SUBSYSTEM: mangrove triterpenoid biosynthesis</html:p>
<html:p>SUBSYSTEM: avenacin biosynthesis</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6948" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8255" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP80F1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( littorine mutase )</html:p>
<html:p>SUBSYSTEM: hyoscyamine and scopolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7996" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__HYOSCYAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8248" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP82E4v1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: nicotine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2748" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7569" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( menG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6947" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__3__45__PHYTYL__45__14__45__NAPHTHOQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8247" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: nicotine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: NIACINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7994" stoichiometry="1"/>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8246" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: N-methyl-&amp;Delta;1-pyrrolinium cation biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7993" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7994" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7567" name="nitrile hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrile hydratase subunit )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLEYL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__237" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHTRANSBARK__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8" stoichiometry="1"/>
      <speciesReference species="METOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7568" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ABC4 ) or ( menA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXYNAPHTHOATE" stoichiometry="1"/>
      <speciesReference species="PHYTYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6947" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7565" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( guanidinobutyrase subunit )</html:p>
<html:p>SUBSYSTEM: arginine degradation XI</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__824" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__2__45__OXOPENTANOATE" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6762" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BEAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: volatile benzenoid ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.84</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6501" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7563" name="D-arginine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__220" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__824" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6763" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glutathione-mediated detoxification</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__Substituted__45__L__45__Cysteines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="__124__Thiols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7564" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginine-&amp;alpha;-ketoglutarate transaminase subunit )</html:p>
<html:p>SUBSYSTEM: arginine degradation XI</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__824" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TMAOREDUCT__45__RXN" name="Trimethylamine-N-oxide reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trimethylamine N-oxide reductase II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.6.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRIMENTHLAMINE__45__N__45__O" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRIMETHYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALA__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( treF ) or ( treA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytoplasmic trehalase ) or ( periplasmic trehalase )</html:p>
<html:p>SUBSYSTEM: trehalose degradation II (trehalase)</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.28</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3103" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AmAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aureusidin synthase )</html:p>
<html:p>SUBSYSTEM: aurone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.21.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3021" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3001" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AmAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aureusidin synthase )</html:p>
<html:p>SUBSYSTEM: aurone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.21.3.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3021" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2982" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R344__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobA ) or ( cobO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)yrinic acid a,c-diamide adenosyltransferase subunit ) or ( CobO )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__694" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__107__45__RXN" name="17-O-deacetylvindoline O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vindoline and vinblastine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.107</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_17__45__O__45__DEACETYLVINDOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VINDOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__CARBAMOYLSARCOSINE__45__AMIDASE__45__RXN" name="N-carbamoylsarcosine amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( A17978 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-carbamoylsarcosine amidohydrolase subunit ) or ( N-carbamoylsarcosine amidohydrolase subunit )</html:p>
<html:p>SUBSYSTEM: creatinine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.59</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEHYDDEOXPHOSGALACT__45__ALDOL__45__RXN" name="2-dehydro-3-deoxyphosphogalactonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dgoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: D-galactonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.21</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDRO__45__DEOXY__45__GALACTONATE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOSE__45__6__45__PHOSPHATE__45__PHOSPHOKETOLASE__45__RXN" name="Fructose-6-phosphate phosphoketolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xfp ) or ( xfp ) or ( LEUM_1961 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-6-phosphate phosphoketolase &amp;alpha; subunit and fructose-6-phosphate phosphoketolase &amp;beta; subunit ) or ( D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase ) or ( phosphoketolase subunit )</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8243" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation VII</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__6__45__AMINO__45__CAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINOPENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7580" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-4 ) or ( KO1 ) or ( KO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ent-kaurene oxidase ) or ( ent-kaurene oxidase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>SUBSYSTEM: superpathway of GA12 biosynthesis</html:p>
<html:p>SUBSYSTEM: GA12 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.78</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ENT__45__KAUR__45__16__45__EN__45__19__45__AL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__132" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8244" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diamine oxidase ) or ( N-methylputrescine oxidase )</html:p>
<html:p>SUBSYSTEM: N-methyl-&amp;Delta;1-pyrrolinium cation biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.22</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__394" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7993" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase class 2 subunit )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation II (MEOS)</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7578" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: resveratrol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6954" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6955" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8234" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 3&apos;GT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gentiodelphin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7960" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7963" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catalase subunit )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLYSINE__45__DEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcd ) or ( pcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>SUBSYSTEM: lysine degradation VI</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.31</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8237" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BADH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: bixin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7968" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7971" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP2E1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 2E1 )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation II (MEOS)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8236" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LCO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: bixin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.13.12.-</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__7969</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__114" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7968" stoichiometry="1"/>
      <speciesReference species="CPD__45__7969" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8239" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nBMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: bixin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7972" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7973" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8238" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nBMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: bixin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7972" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__109__45__RXN" name="Demethylsterigmatocystin 6-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dmtA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-methyltransferase I )</html:p>
<html:p>SUBSYSTEM: sterigmatocystin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.109</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__DEMETHYLSTERIGMATOCYSTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="STERIGMATOCYSTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRCARBOXY__45__RXN" name="Phosphoribosylaminoimidazole carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.21</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CROBETREDUCT__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( caiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: carnitine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CROTONOBETAINYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__BUTYROBETAINYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITRAMALATE__45__COA__45__TRANSFERASE__45__RXN" name="Citramalate CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of citramalate-ACP transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="S__45__CITRAMALATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__627" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__80__45__RXN" name="Nicotianamine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( naatA ) or ( naatB ) or ( OsNAAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2&apos;-deoxymugineic acid phytosiderophore biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.80</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__463" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7228" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__74__45__RXN" name="Indolepyruvate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO10 ) or ( PDC1 ) or ( PDC5 ) or ( ipdC ) or ( ipdC ) or ( PDC6 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-keto-3-methylvalerate decarboxylase subunit ) or ( pyruvate decarboxylase 1 subunit ) or ( pyruvate decarboxylase 2 subunit ) or ( indole-3-pyruvate decarboxylase subunit ) or ( indolepyruvate decarboxylase subunit ) or ( pyruvate decarboxylase 3 subunit ) or ( indolepyruvate decarboxylase subunit a and indolepyruvate decarboxylase subunit b and indolepyruvate decarboxylase subunit c )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VII (via indole-3-pyruvate)</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis I</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VIII (to tryptophol)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.74</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINO__45__CARBOXYMUCONATE__45__SEMIALDEHYDE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( nbaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2-amino-3-carboxymuconate semialdehyde degradation to 2-oxopentenoate</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation I</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.45</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3121" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1102" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__ACETYL__45__BETA__45__4__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3122" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1102" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__ACETYL__45__BETA__45__6__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6741" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IEMT1 ) or ( EOMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IEMT1 subunit ) or ( EOMT1 subunit )</html:p>
<html:p>SUBSYSTEM: volatile cinnamoic ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.146</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6481" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6482" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__2__46__12__45__RXN" name="Nicotinamide phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( slr0788 ) or ( nadV )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.12</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8267" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT78D1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: quercetin glucoside biosynthesis (Arabidopsis)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__520" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8013" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9799" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal multifunctional enzyme type 2 subunit )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7275" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7257" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXY__45__MANDELATE__45__RACEMASE__45__RXN" name="Mandelate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdlA ) or ( mdlA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__105" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__106" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8268" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73C6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: quercetin glucoside biosynthesis (Arabidopsis)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8013" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8011" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9798" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (25S)-3&amp;alpha;,7&amp;alpha;,12&amp;alpha;-trihydroxy-5&amp;beta;-cholestanoyl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10505" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7243" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8269" name="Sulfur reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( psrC and psrB and psrA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polysulfide reductase &amp;alpha; subunit and polysulfide reductase &amp;beta; subunit and polysulfide reductase &amp;gamma; subunit ) or ( sulfide dehydrogenase &amp;beta; subunit and sulfide dehydrogenase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: sulfur reduction II (via polysulfide)</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Polysulfides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="__124__Polysulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9797" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Amacr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-methylacyl-CoA racemase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__71" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10505" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATE__45__GLUCOSYLTRANSFERASE__45__RXN" name="Nicotinate glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: N-glucosylnicotinate metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.196</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__446" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TEICHOICSYN5__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tagE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: teichoic acid (poly-glycerol) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.52</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Teichoic__45__P__45__Gro__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Teichoic__45__P__45__Gro__45__Glc__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CVOMT1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CVOMT1 subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: volatile cinnamoic ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.146</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6483" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6484" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9796" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1c9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&amp;alpha;-hydroxysteroid dehydrogenase (A-specific) )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.213</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10503" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__BETA__45__CHOLESTANE__45__3__45__ALPHA7__45__ALPHA12__45__ALP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8275" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT3g26830 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYP71B15 )</html:p>
<html:p>SUBSYSTEM: camalexin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__CARBOXY__45__HYDRO__45__THIAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAZOL__45__YL__45__INDOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8277" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( STS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: galactosylcyclitol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: CPD__45__458</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
      <speciesReference species="CPD__45__8046" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8047" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8271" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: quercetin glucoside biosynthesis (Arabidopsis)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__437" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8033" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8270" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: kaempferol glucoside biosynthesis (Arabidopsis)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__453" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8034" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gbsB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis II (Gram-positive bacteria)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8272" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: carbon disulfide oxidation II (aerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__844" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="CARBONYL__45__SULFIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FEMOCOSYN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nifE and nifN and nifB and nifQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrogenase Fe-Mo cofactor biosynthesis protein NifN and nitrogenase Fe-Mo cofactor biosynthesis protein NifE and NifB protein and NifQ protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FE__43__2" stoichiometry="7"/>
      <speciesReference species="NITROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="CPD__45__7046" stoichiometry="9"/>
      <speciesReference species="MO__43__2" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__41" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__5__45__XYLENOL__45__METHYLHYDROXYLASE__45__RXN" name="3,5-xylenol methylhydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylenol methylhydroxylase subunit )</html:p>
<html:p>SUBSYSTEM: m-cresol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: OH</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__112" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OH__45__BENZYL__45__ALCOHOL" stoichiometry="1"/>
      <speciesReference species="OH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Amine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indolethylamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.49</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__All__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__45__METHYLATED__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__220__45__RXN" name="Indoxyl-UDPG glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: indican biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.220</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOXYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDICAN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4703" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: biochanin A conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.115</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4563" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4564" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__77__45__RXN" name="N-carbamoyl-D-amino acid hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-carbamoyl-D-amino acid amidohydrolase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.77</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Carbamoyl__45__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4702" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: biochanin A conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.170</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIOCHANIN__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4563" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMSUCTRAN__45__RXN" name="Homoserine O-succinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( metA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MetA )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.46</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4705" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: biochanin A conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4563" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOCHANIN__45__A" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4704" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: biochanin A conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4564" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4563" stoichiometry="1"/>
      <speciesReference species="MALONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8266" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73C6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: kaempferol glucoside biosynthesis (Arabidopsis)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__461" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8012" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8264" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B1 ) or ( UGT73B2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: quercetin glucoside biosynthesis (Arabidopsis)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.237</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__520" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8006" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9794" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1d1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;4-3-oxosteroid 5&amp;beta;-reductase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7237" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10503" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8263" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B1 ) or ( UGT73B2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: kaempferol glucoside biosynthesis (Arabidopsis)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.237</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__90" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8007" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8262" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( OMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methylquercetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__520" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8004" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINASE__45__RXN" name="Adenosylhomocysteinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ahcy ) or ( SAHH ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylhomocysteine hydrolase subunit ) or ( NA ) or ( S-adenosylhomocysteine hydrolase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>PROTEIN_CLASS: 3.3.1.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEXOKINASE__45__RXN" name="Hexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hxk2 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Hexoses__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__HEXOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6724" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BEBT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: volatile benzenoid ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZYL__45__ALCOHOL" stoichiometry="1"/>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6443" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_24__45__DICHLOROPHENOL__45__6__45__MONOOXYGENASE__45__RXN" name="2,4-dichlorophenol 6-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tfdBI ) or ( tfdBII )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dichlorophenol 6-monooxygenase I ) or ( 2,4-dichlorophenol monooxygenase II )</html:p>
<html:p>SUBSYSTEM: 2,4-dichlorophenoxyacetate  degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.20</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_24__45__DICHLOROPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_35__45__DICHLOROCATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8289" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: kaempferol triglucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.239</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__453" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8067" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6723" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AlBSMT1 ) or ( AtBSMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AlBSMT1 subunit ) or ( AtBSMT1 subunit )</html:p>
<html:p>SUBSYSTEM: volatile benzenoid ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__110" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6442" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6722" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AlBSMT1 ) or ( AtBSMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AlBSMT1 subunit ) or ( AtBSMT1 subunit )</html:p>
<html:p>SUBSYSTEM: volatile benzenoid ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6441" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: volatile cinnamoic ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__674" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6421" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SELENOCYSTEINE__45__LYASE__45__RXN" name="Selenocysteine lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( sufS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-selenocysteine lyase (and L-cysteine desulfurase) monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__SELENOCYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__678" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOKIN__45__RXN" name="Glucokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glk ) or ( TM1469 ) or ( GCK ) or ( glk ) or ( GLK1 ) or ( glcK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( glucokinase subunit ) or ( NA ) or ( glucokinase subunit ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: trehalose degradation II (trehalase)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: trehalose degradation IV</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: trehalose degradation V</html:p>
<html:p>SUBSYSTEM: trehalose degradation I (low osmolarity)</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8292" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( STS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__O__45__METHYL__45__MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8071" stoichiometry="1"/>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8295" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8073" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8074" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8294" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2187" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8073" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8297" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8075" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8076" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8296" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2188" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8075" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHA__45__L__45__FUCOSIDASE__45__RXN" name="&amp;alpha;-L-fucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FXG1 ) or ( FUC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-fucosidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.51</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AN__45__ALPHA__45__L__45__FUCOSIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="L__45__FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFFEOXIDO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfur:ferric ion oxidoreductase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfide oxidation (Acidithiobacillus ferrooxidans)</html:p>
<html:p>SUBSYSTEM: sulfur oxidation II (Fe+3-dependent)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Thiols__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: FE__43__3</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Perthiols__124__" stoichiometry="1"/>
      <speciesReference species="FE__43__3" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Thiols__124__" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8299" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2189" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8078" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8298" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8077" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2189" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8291" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: kaempferol triglucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.173</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: P__45__COUMAROYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8068" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8069" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8290" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: kaempferol triglucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.240</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8067" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8068" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 7-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4612" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__160__45__RXN" name="Vinorine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.160</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_16__45__EPIVELLOSIMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VINORINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TOLUENE__45__DIOL__45__DEHYDROGENASE__45__RXN" name="Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( todD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation V (aerobic) (via toluene-cis-diol)</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate (via toluene-cis-diol)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.19</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TOLUENECISDHDIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__111" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4729" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 7-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4604" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4607" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4728" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 9-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4209" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4603" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8278" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: galactosylcyclitol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: CPD__45__458</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8046" stoichiometry="1"/>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8048" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4727" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 7-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4209" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8279" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: galactosylcyclitol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: CPD__45__458</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8047" stoichiometry="1"/>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8049" stoichiometry="1"/>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4726" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ZOG1 ) or ( UGT73C5 ) or ( UGT85A1 ) or ( UGT73C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( zeatin-O-glucosyltransferase ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins-O-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__332" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4617" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4725" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 9-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__332" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4616" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4724" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 7-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__332" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4615" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4723" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ZOG1 ) or ( UGT73C5 ) or ( UGT85A1 ) or ( UGT73C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( zeatin-O-glucosyltransferase ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins-O-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.203</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4614" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSINE__45__NUCLEOSIDASE__45__RXN" name="Adenosine nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( rihC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine nucleosidase ) or ( ribonucleoside hydrolase 3 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.7</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4722" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 9-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8284" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajugose biosynthesis I (galactinol-dependent)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: CPD__45__458</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
      <speciesReference species="CPD__45__170" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8065" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DicGT5 ) or ( DicGT4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: chalcone 2&apos;-O-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APIGENIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8062" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8282" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( STS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1099" stoichiometry="1"/>
      <speciesReference species="CPD__45__8058" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__METHYL__45__MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__170" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8281" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STS1 ) or (  ) or ( STS1 ) or ( RFS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: galactosylcyclitol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: CPD__45__458</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__METHYL__45__MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8058" stoichiometry="1"/>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8288" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajugose biosynthesis I (galactinol-dependent)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: CPD__45__458</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
      <speciesReference species="CPD__45__8065" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8066" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOKIN__45__RXN" name="Ribokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rbsK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribokinase )</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.15</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8287" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GGT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajugose biosynthesis II (galactinol-independent)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: SUCROSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1099" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__170" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8286" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GGT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajugose biosynthesis II (galactinol-independent)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__170" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1099" stoichiometry="1"/>
      <speciesReference species="CPD__45__8065" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8285" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GGT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajugose biosynthesis II (galactinol-independent)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8065" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__170" stoichiometry="1"/>
      <speciesReference species="CPD__45__8066" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLACETATE__45____45__COA__45__LIGASE__45__RXN" name="Phenylacetate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( paaK ) or ( paaK ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylacetate-CoA ligase ) or ( NA ) or ( phenylacetate-CoA ligase )</html:p>
<html:p>SUBSYSTEM: phenylacetate degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: phenylacetate degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of phenylethylamine degradation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.30</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLACETATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__207" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TOLUENE__45__DIOXYGENASE__45__RXN" name="Toluene dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( todB and todC2 and todA and todC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( toluene dioxygenase iron-sulfur protein &amp;alpha; subunit and toluene dioxygenase iron-sulfur protein &amp;beta; subunit and toluene dioxygenase ferredoxin subunit and toluene dioxygenase reductase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation V (aerobic) (via toluene-cis-diol)</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate (via toluene-cis-diol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.11</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TOLUENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TOLUENECISDHDIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DARABISOM__45__RXN" name="Arabinose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fucI ) or ( fucI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-arabinose isomerase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation II</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9758" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dimethylsulfoniopropionate biosynthesis II (Spartina)</html:p>
<html:p>SUBSYSTEM: dimethylsulfoniopropionate biosynthesis I (Wollastonia)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10472" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SS__45__DIMETHYL__45__BETA__45__PROPIOTHETIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9756" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dimethylsulfoniopropionate biosynthesis II (Spartina)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__397" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10471" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACECOATRANS__45__RXN" name="Acetate CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( atoD ) or (  ) or ( atoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( acetyl-CoA:acetoacetyl-CoA transferase, &amp;alpha; subunit ) or ( NA ) or ( acetyl-CoA:acetoacetyl-CoA transferase, &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9757" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dimethylsulfoniopropionate biosynthesis II (Spartina)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10471" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10472" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__5__46__4__45__RXN" name="Cyanoalanine nitrilase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At5g22300 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-cyano-L-alanine hydrolase )</html:p>
<html:p>SUBSYSTEM: cyanide detoxification</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__603" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6701" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( garA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glutathione amide metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6401" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6402" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__KIN__45__RXN" name="NAD(+) kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NADK1 ) or ( nadK ) or ( NADK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADK1 subunit ) or ( NAD kinase monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NAD/NADH phosphorylation and dephosphorylation</html:p>
<html:p>SUBSYSTEM: NAD phosphorylation and dephosphorylation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.23</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9752" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B5 ) or ( UGT74E2 ) or ( UGT73B2 ) or ( UGT73C6 ) or ( UGT73B4 ) or ( UGT73C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2,4,6-trinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10447" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10449" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATE__45__1__45__EPIMERASE__45__RXN" name="Glucose-6 phosphate 1-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: starch degradation</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: sucrose degradation IV</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>SUBSYSTEM: trehalose degradation V</html:p>
<html:p>SUBSYSTEM: sucrose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6702" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( garB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione amide reductase subunit )</html:p>
<html:p>SUBSYSTEM: glutathione amide metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6402" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6401" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__FORMIMINOTRANSFERASE__45__RXN" name="Glycine formiminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine formimidoyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.4</html:p>
<html:p>SIDE: THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
      <speciesReference species="N__45__FORMIMINO__45__GLYCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="CPD__45__671" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3164" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-O-IAGlu hydrolase )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.1.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__ACETYL__45__BETA__45__4__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-O-IAGlu hydrolase )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.1.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__ACETYL__45__BETA__45__6__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3166" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3165" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-O-IAGlu hydrolase )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.1.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1102" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1061" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP86A8 ) or ( CYP94C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acid &amp;omega;-hydroxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PALMITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_16__45__HYDROXYPALMITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At2g29730 ) or ( At2g18560 ) or ( At2g29710 ) or ( At1g01420 ) or ( AT4g01070 ) or (  ) or ( AT3g29630 ) or ( At2g29740 ) or ( At2g18570 ) or ( AT5g54060 ) or ( At1g01390 ) or ( At2g22930 ) or ( At2g29750 ) or ( UGT73B2 ) or ( AT5g54010 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( NA ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( NA ) or ( flavonol 3-O-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: kaempferol triglucoside biosynthesis</html:p>
<html:p>SUBSYSTEM: kaempferol glucoside biosynthesis (Arabidopsis)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.91</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__90" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__453" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__166__45__RXN" name="2-&amp;alpha;-hydroxytaxane 2-O-benzoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 2&amp;alpha;-O-benzoyltransferase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: taxol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.166</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: BENZOYLCOA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
      <speciesReference species="_10__45__DEACETYL__45__2__45__DEBENZOYLBACCATIN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_10__45__DEACETYLBACCATIN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9762" name="dimethylsulfone reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of dimethylsulfone degradation</html:p>
<html:p>SUBSYSTEM: dimethylsulfone degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10437" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DMSO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9760" name="Dimethylpropiothetin dethiomethylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dddD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dimethylsulfoniopropionate degradation II (cleavage)</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="SS__45__DIMETHYL__45__BETA__45__PROPIOTHETIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10473" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9745" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B5 ) or ( UGT74E2 ) or ( UGT73B2 ) or ( UGT73C6 ) or ( UGT73B4 ) or ( UGT73C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2,4,6-trinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10450" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10452" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9748" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B5 ) or ( UGT74E2 ) or ( UGT73B2 ) or ( UGT73C6 ) or ( UGT73B4 ) or ( UGT73C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2,4,6-trinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10457" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10460" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDHMSARC__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cdhE and cdhC and cdhD and cdhB and cdhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;epsilon; subunit and &amp;delta; subunit and &amp;gamma; subunit and &amp;alpha; subunit and &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: methanogenesis from acetate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: CPD__45__8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BAI3OXO__45__OXRED__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxo-&amp;Delta;4-steroid oxidoreductase )</html:p>
<html:p>SUBSYSTEM: cholate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OXO__45__CHOLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXO__45__DELTA4__45__CHOLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9743" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B5 ) or ( UGT74E2 ) or ( UGT73C6 ) or ( UGT73B4 ) or ( UGT73C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2,4,6-trinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10447" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10448" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNMUTST__45__RXN" name="D-ornithine 4,5-aminomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( oraE and oraS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-ornithine aminomutase component E subunit and D-ornithine aminomutase component S subunit )</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__217" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_24DINH2__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__AMINOTRANSFERASE__45__RXN" name="Glycine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AGT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxylate aminotransferase )</html:p>
<html:p>SUBSYSTEM: photorespiration</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.4</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9749" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B5 ) or ( UGT74E2 ) or ( UGT73B2 ) or ( UGT73C6 ) or ( UGT73B4 ) or ( UGT73C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2,4,6-trinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10457" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10458" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At2g29730 ) or ( At2g18560 ) or ( At2g29710 ) or ( At1g01420 ) or ( AT4g01070 ) or ( AT3g29630 ) or ( At2g29740 ) or ( At2g18570 ) or ( AT5g54060 ) or ( At1g01390 ) or ( At2g22930 ) or ( At2g29750 ) or ( UGT73B2 ) or ( AT5g54010 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( flavonol 3-O-glucosyltransferase ) or ( NA ) or ( flavonol 3-O-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: quercetin glucoside biosynthesis (Arabidopsis)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.91</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__520" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__437" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLPYRUVATE__45__HYDROLASE__45__RXN" name="Acetylpyruvate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: orcinol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__612" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCDEH__45__RXN" name="Glycerol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( gldA ) or ( dhaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol dehydrogenase subunit ) or ( GldA ) or ( glycerol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: glycerol degradation II</html:p>
<html:p>SUBSYSTEM: glycerol degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.6</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__CARBOXY__45__2__45__OXO__45__3__45__HEXENEDIOATE__45__RXN" name="2-oxopent-4-enoate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pmdE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>SUBSYSTEM: methylgallate degradation</html:p>
<html:p>SUBSYSTEM: gallate degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.80</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__OH__45__4__45__ACETYL__45__2__45__OXOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: IAA degradation I</html:p>
<html:p>SUBSYSTEM: IAA degradation IV</html:p>
<html:p>SUBSYSTEM: IAA degradation VII</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXINDOLE__45__3__45__ACETIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CAFFEOYL__45__COA_TO_CO__45__A_COF_RXN" name="CAFFEOYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CAFFEOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDINE__45__KINASE__45__RXN" name="Pseudouridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( yeiC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pseudoeuridine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.83</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__497" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9751" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B5 ) or ( UGT74E2 ) or ( UGT73B2 ) or ( UGT73C6 ) or ( UGT73B4 ) or ( UGT73C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2,4,6-trinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10455" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10456" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9774" name="biotin-independent malonate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mdcC and mdcD and mdcA and mdcE and mdcH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malonate decarboxylase acetyl-[acp]:malonate-[acp] transferase component and malonate decarboxylase [acyl carrier protein] component and malonate decarboxylase malonyl-[acp] decarboxylase component &amp;alpha; subunit and [acyl-carrier protein] S-malonyltransferase and malonate decarboxylase malonyl-[acp] decarboxylase component &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.88</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__527" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5g63580 ) or ( AT3g50210 ) or ( AT3g19010 ) or ( At2g44800 ) or ( AT5g63590 ) or ( FLS ) or ( At1g49390 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavonol synthase ) or ( flavonol synthase ) or ( flavonol synthase ) or ( flavonol synthase ) or ( flavonol synthase ) or ( flavonol synthase ) or ( flavonol synthase )</html:p>
<html:p>SUBSYSTEM: flavonol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.23</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__474" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__520" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OXALODECARB__45__RXN" name="Oxaloacetate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( eda )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Eda )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__525" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5g07990 ) or ( Ht1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavonoid 3&apos;-hydroxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: flavonol biosynthesis</html:p>
<html:p>SUBSYSTEM: syringetin biosynthesis</html:p>
<html:p>SUBSYSTEM: leucodelphinidin biosynthesis</html:p>
<html:p>SUBSYSTEM: leucopelargonidin and leucocyanidin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROKAEMPFEROL__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__474" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9778" name="N-succinylornithine carbamoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( argF&apos; )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="N2__45__SUCCINYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10483" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9779" name="phosphatidylinositol-4,5-bisphosphate 4-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ipgD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.78</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__1D__45__MYO__45__INOSITOL__45__5__45__PHOSPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R127__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__UREIDO__45__4__45__IMIDAZOLE_CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__89__45__RXN" name="Tetrahydrocolumbamine 2-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CoOMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: palmatine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.89</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__TETRAHYDROCOLUMBAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRAHYDROPALMATINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__474" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT78D1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: kaempferol glucoside biosynthesis (Arabidopsis)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: DTDP__45__RHAMNOSE</html:p>
<html:p>SIDE: TDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__90" stoichiometry="1"/>
      <speciesReference species="DTDP__45__RHAMNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
      <speciesReference species="CPD1F__45__461" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALTRODEHYDRAT__45__RXN" name="Altronate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( uxaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hexuronide and hexuronate degradation</html:p>
<html:p>SUBSYSTEM: D-galacturonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.7</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALTRONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pgsA ) or ( PGPS1 ) or ( PGS1 ) or ( LOC_Os03g17520.1 ) or ( PGPS2 ) or ( LOC_Os01g57930.1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( PGPS1 ) or ( phosphatidylglycerophosphate synthase ) or ( CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, putative, expressed ) or ( NA ) or ( cardiolipin synthetase, putative, expressed ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis II</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis I (plastid)</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.5</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9780" name="futalosine hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TTHA0556 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10477" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__10484" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA_TO_CO__45__A_COF_RXN" name="ACYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9782" name="biotin-dependent malonate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( madH and madA and madF and madC and madE and madD and madB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA and malonyl-S-ACP:biotin-protein carboxyltransferase &amp;beta; subunit and malonyl-S-ACP:biotin-protein carboxyltransferase &amp;alpha; subunit and NA and NA and malonate decarboxylase biotin-carrier protein subunit and malonate decarboxylase acyl-carrier protein subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.89</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9781" name="hydantoin racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hyuE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__5__45__Monosubstituted__45__Hydantoins__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__L__45__5__45__Monosubstituted__45__Hydantoins__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1026" name="fatty acid elongation" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CER6 ) or ( KCS1 ) or ( FAE1 ) or ( FAE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-ketoacyl-CoA synthase and hydroxyacyl-CoA dehydratse and 3-ketoacyl-CoA reductase and enoyl-CoA reductase ) or ( hydroxyacyl-CoA dehydratse and 3-ketoacyl-CoA synthase and 3-ketoacyl-CoA reductase and enoyl-CoA reductase ) or ( 3-ketoacyl-CoA synthase and hydroxyacyl-CoA dehydratse and 3-ketoacyl-CoA reductase and enoyl-CoA reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: wax esters biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VERY__45__LONG__45__CHAIN__45__FATTY__45__ACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9766" name="dimethylsulfide hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dsoE and dsoF and dsoA and dsoB and dsoC and dsoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DMS oxygenase &amp;delta; subunit and DMS oxygenase &amp;gamma; subunit and DMS oxygenase &amp;epsilon; subunit and DMS oxygenase &amp;beta; subunit and DMS oxygenase &amp;alpha; subunit and DMS oxygenase &amp;zeta; subunit )</html:p>
<html:p>SUBSYSTEM: dimethylsulfide degradation II (oxidation)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7670" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DMSO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9767" name="dimethylsulfoxide hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dsoE and dsoF and dsoA and dsoB and dsoC and dsoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DMS oxygenase &amp;delta; subunit and DMS oxygenase &amp;gamma; subunit and DMS oxygenase &amp;epsilon; subunit and DMS oxygenase &amp;beta; subunit and DMS oxygenase &amp;alpha; subunit and DMS oxygenase &amp;zeta; subunit )</html:p>
<html:p>SUBSYSTEM: dimethylsulfide degradation II (oxidation)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DMSO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10437" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSINE__45__23__45__AMINOMUTASE__45__RXN" name="Lysine 2,3-aminomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kamA ) or ( kamA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysine 2,3-aminomutase ) or ( L-lysine 2,3-aminomutase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__233" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9769" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sfnG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dimethylsulfide degradation II (oxidation)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FMN</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FMNH2</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10437" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3746" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1022" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G57750 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cuticular wax biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alkanes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Secondary__45__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1025" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G02205 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty aldehyde decarbonylase )</html:p>
<html:p>SUBSYSTEM: cuticular wax biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.99.5</html:p>
<html:p>SIDE: CARBON__45__MONOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
      <speciesReference species="__124__Alkanes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HALOALKANE__45__DEHALOGENASE__45__RXN" name="Haloalkane dehalogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dhlA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__Haloalkanes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Primary__45__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Halides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAPOXNPHOSPHN__45__RXN" name="Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( PRK and CP12-2 and GapA-1 ) or ( gap ) or ( GapA-1 ) or ( gap ) or ( GPD ) or ( gapC ) or ( gapA ) or ( GAPC ) or ( gapA ) or ( GapCp1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyceraldehyde 3-phosphate dehydrogenase subunit ) or ( CP12 subunit and glyceraldehyde 3-phosphate dehydrogenase subunit and phosphoribulokinase subunit ) or ( glyceraldehyde-3-phosphate dehydrogenase subunit ) or ( glyceraldehyde 3-phosphate dehydrogenase subunit ) or ( Gap ) or ( glyceraldehyde-3-phosphate dehydrogenase subunit ) or ( glyceraldehyde-3-phosphate dehydrogenase subunit ) or ( NA ) or ( NA ) or ( glyceraldehyde 3-phosphate dehydrogenase-A monomer ) or ( NA ) or ( NAD-dependent glyceraldehyde-3-phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: glycolysis IV (plant cytosol)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9770" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ssuD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alkanesulfonate monooxygenase subunit )</html:p>
<html:p>SUBSYSTEM: dimethylsulfide degradation II (oxidation)</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.5</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FMN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FMNH2</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3746" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9773" name="3,4-dihydroxyphenylalanine oxidative deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,4-dihydroxyphenylalanine oxidative deaminase &amp;epsilon; subunit and 3,4-dihydroxyphenylalanine oxidative deaminase &amp;alpha; subunit and 3,4-dihydroxyphenylalanine oxidative deaminase &amp;beta; subunit and 3,4-dihydroxyphenylalanine oxidative deaminase &amp;gamma; subunit and 3,4-dihydroxyphenylalanine oxidative deaminase &amp;delta; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.12.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_34__45__DIHYDROXYPHENYLPYRUVATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__97__46__1__46__2__45__RXN" name="Pyrogallol hydroxyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrogallol transhydroxylase subunit )</html:p>
<html:p>SUBSYSTEM: gallate degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.2</html:p>
<html:p>SIDE: _1235__45__TETRAHYDROXYBENZENE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1235__45__TETRAHYDROXYBENZENE" stoichiometry="1"/>
      <speciesReference species="PYROGALLOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1235__45__TETRAHYDROXYBENZENE" stoichiometry="1"/>
      <speciesReference species="CPD__45__16" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREODEHYD__45__RXN" name="L-threonine 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tdh )</html:p>
<html:p>SUBSYSTEM: threonine degradation II</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>SUBSYSTEM: aminopropanol biosynthesis</html:p>
<html:p>SUBSYSTEM: aminopropanol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.103</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__274__45__RXN" name="2,5-didehydrogluconate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dkgB ) or ( dkgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.274</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_25__45__DIDEHYDRO__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__CINNAMATE__45__2__45__MONOOXYGENASE__45__RXN" name="Trans-cinnamate 2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coumarin biosynthesis (via 2-coumarate)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.14</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__674" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__COUMARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4OHBENZOATE__45__OCTAPRENYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.39</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9603" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( treT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose synthase subunit )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis VI</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.245</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="__124__D__45__Glucose__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: linoleate biosynthesis II (animals)</html:p>
<html:p>PROTEIN_CLASS: 1.14.19.6</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OLEOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__18" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4561" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pisatin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4462" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3942" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9608" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rif-orf5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of rifamycin B biosynthesis</html:p>
<html:p>SUBSYSTEM: rifamycin B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10240" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10239" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMACTRAN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( speG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SpeG )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLSPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__1439" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( otsB1 ) or ( Rv3400 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate phosphatase OtsB1 ) or ( hydrolase )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__774" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1354" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__DEHYDRATASE__45__RXN" name="3-dehydroquinate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aroC ) or ( quiB ) or (  ) or ( aroD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AroC ) or ( NA ) or ( NA ) or ( AroD )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: quinate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXBUTYRYL__45__COA__45__DEHYDRATASE__45__RXN" name="3-hydroxybutyryl-CoA dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( crt ) or ( crt1 ) or ( ech ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( crotonase subunit ) or ( NA ) or ( enoyl-CoA hydratase subunit ) or ( crotonyl-CoA hydratase [(S)-3-hydroxybutyryl-CoA-forming] )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate I</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.55</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__1437" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( otsB1 ) or ( Rv3400 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate phosphatase OtsB1 ) or ( hydrolase )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__772" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1346" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__1438" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( otsB1 ) or ( Rv3400 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate phosphatase OtsB1 ) or ( hydrolase )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__773" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1353" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__1435" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( otsB1 ) or ( Rv3400 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate phosphatase OtsB1 ) or ( hydrolase )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__768" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1344" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__1436" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( otsB1 ) or ( Rv3400 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose-6-phosphate phosphatase OtsB1 ) or ( hydrolase )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__771" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1345" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9613" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( treT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose synthase subunit )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis VII</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Glucose__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9616" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sbDES2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sorgoleone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10253" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10254" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9610" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rif-orf20 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of rifamycin B biosynthesis</html:p>
<html:p>SUBSYSTEM: rifamycin B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10238" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10237" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9611" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rif-orf14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 27-O-demethyl-rifamycin SV methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of rifamycin B biosynthesis</html:p>
<html:p>SUBSYSTEM: rifamycin B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10237" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10236" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R216__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksD ) or ( aksE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__301" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__319" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MVHMETH__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mvhD and mvhG and mvhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydrogenase &amp;delta; subunit and hydrogenase &amp;gamma; subunit and hydrogenase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9617" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sbDES3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sorgoleone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10254" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10255" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9619" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sbOMT3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sorgoleone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10256" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10257" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__55__45__RXN" name="Protopine 6-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.55</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__HYDROXYPROTOPINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOLICHOL__45__KINASE__45__RXN" name="Dolichol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SEC59 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.108</html:p>
<html:p>COFACTOR: CDP</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__77__45__RXN" name="Protein-L-isoaspartate(D-aspartate) O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pcm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-isoaspartate protein carboxylmethyltransferase type II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.77</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOASPARTATES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CELLULOSE__45__SYNTHASE__45__UDP__45__FORMING__45__RXN" name="Cellulose synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CesA3 ) or ( CesA1 ) or ( CesA4 ) or ( CesA6 ) or ( CesA8 ) or ( CesA7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cellulose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.12</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORPYRLY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: 4-hydroxybenzoate biosynthesis III (yeast)</html:p>
<html:p>SUBSYSTEM: 4-hydroxybenzoate biosynthesis II (bacteria and fungi)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.40</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__66__45__RXN" name="N(2)-(2-carboxyethyl)arginine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ceaS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N2-(carboxyethyl)arginine synthase subunit )</html:p>
<html:p>SUBSYSTEM: clavulanate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.66</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__N2__45__2__45__CARBOXYETHYLARGININE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__13__46__11__46__16__45__RXN" name="3-carboxyethylcatechol 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mhpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-(2,3-dihydroxyphenyl)propionate dioxygenase monomer )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDROXYPHENYL__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__157" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R208__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksD ) or ( aksE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__151" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R4__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ahpF and ahpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AhpC component and AhpF component )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.4.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alkyl__45__Hydro__45__Peroxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM2__45__RXN" name="Cytidine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cdd ) or ( cdd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cdd ) or ( NA )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__DEHYDRATASE__45__RXN" name="Glycerol dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dhaB3 and dhaB1 and dhaB4 ) or ( dhaC and dhaE and dhaB ) or ( dhaB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol dehydratase medium subunit and glycerol dehydratase small subunit and glycerol dehydratase large subunit ) or ( glycerol dehydratase small subunit and glycerol dehydratase medium subunit and glycerol dehydratase large subunit ) or ( glycerol dehydratase subunit )</html:p>
<html:p>SUBSYSTEM: glycerol degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.30</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYPROPANAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCPALDOL__45__RXN" name="L-fuculose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fucA ) or ( MJ1418 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( fuculose-1-phosphate aldolase subunit )</html:p>
<html:p>SUBSYSTEM: lactate biosynthesis</html:p>
<html:p>SUBSYSTEM: fucose degradation</html:p>
<html:p>SUBSYSTEM: superpathway of fucose and rhamnose degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FUCULOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTALD" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOVITEXIN__45__BETA__45__GLUCOSYLTRANSFERASE__45__RXN" name="Isovitexin &amp;beta;-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isovitexin and isovitexin glycosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.106</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVITEXIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOVITEXIN__45__2__45__O__45__B__45__D__45__GLUCOSIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__77__45__RXN" name="Taxane 13-&amp;alpha;-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( taxane 13&amp;alpha;-hydroxylase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: taxol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.77</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAXA__45__42011__45__DIEN__45__5A__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAXA__45__42011__45__DIEN__45__5A13A__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__1120" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxybenzoate biosynthesis I (eukaryotes)</html:p>
<html:p>SUBSYSTEM: 4-hydroxybenzoate biosynthesis III (yeast)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__COUMAROYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__201" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4181" name="Cyclic-guanylate-specific phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yahA ) or ( dos ) or ( gmr ) or ( yhjH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphodiesterase, c-di-GMP-specific ) or ( phosphodiesterase, heme-regulated ) or ( modulator of RNase II stability ) or ( c-di-GMP phosphodiesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.52</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C__45__DI__45__GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DI__45__GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSYLOXYDOCOSANOATE__45__TRANS__45__RXN" name="13-&amp;beta;-D-GLUCOSYLOXYDOCOSANOATE-TRANS-GLUCOSE" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sophorosyloxydocosanoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.158</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__803" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIGLUCO__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__26__45__RXN" name="R-linalool synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MTS1 ) or ( LaLins )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( linalool synthase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: linalool biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.26</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8996" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6903" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtGHBDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-hydroxybutyrate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( POP2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-aminobutyrate transaminase )</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2602" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mutM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formamidopyrimidine DNA glycosylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.23</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Damaged__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__AP__45__Site__45__Created__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2606" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( recO and recR and recF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ssDNA and dsDNA binding,  ATP binding and recombination and repair and protein interacts with RecR and possibly RecF proteins )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Unstable__45__RecA__45__Filament__45__DNA__45__Complex__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Stabilized__45__RecA__45__Filament__45__DNA__45__Complex__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOBUTDEHYDROG__45__RXN" name="Aminobutyraldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( kauB ) or ( ydcW )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminobutyraldehyde dehydrogenase subunit ) or ( NA ) or ( &amp;gamma;-aminobutyraldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: putrescine degradation V</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: putrescine degradation I</html:p>
<html:p>SUBSYSTEM: putrescine degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.19</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__11__46__1__46__2__45__RXN" name="Phosphonoacetate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( phnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PhnA )</html:p>
<html:p>SUBSYSTEM: phosphonoacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.11.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__764" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4042" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCS7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phytoceramides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alpha__45__hydroxyphytoceramides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOCATECHUATE__45__3__45__4__45__DIOXYGENASE__45__RXN" name="Protocatechuate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcaG and pcaH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protocatechuate 3,4-dioxygenase &amp;beta; subunit and protocatechuate 3,4-dioxygenase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__183" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__184" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALAMIN5PSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobV ) or ( cobS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosyl-cobalamin (5&apos;-phosphate) synthase ) or ( CobS )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.26</html:p>
<html:p>SIDE: GMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__RIBAZOLE__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__NUCLEOTID__45__RXN" name="3&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( surE ) or ( cpdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( broad specificity 5&apos;(3&apos;)-nucleotidase and polyphosphatase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__3__46__13__45__RXN" name="4-hydroxyphenylpyruvate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.13</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXYPHENYLACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__37__45__RXN" name="(2-aminoethyl)phosphonate--pyruvate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of 2-aminoethylphosphonate aminotransferase )</html:p>
<html:p>SUBSYSTEM: phosphonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.37</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1106" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__551" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITLY__45__RXN" name="Citrate lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( citF and citD and citE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( citrate lyase, citrate-ACP transferase &amp;alpha; subunit and citrate lyase, acyl carrier &amp;gamma; subunit and citrate lyase, citryl-ACP lyase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHAMLY__45__RXN" name="Ethanolamine ammonia-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( eutB and eutC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ethanolamine ammonia-lyase, probable regulatory subunit and ethanolamine ammonia-lyase, probable catalytic subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOESTER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( yciA ) or ( tesA ) or ( AT1G01710 ) or (  ) or ( tesB ) or ( CESdD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase ) or ( NA ) or ( acyl-CoA thioesterase ) or ( lll ) or ( TesB ) or ( acyl-coA hydrolase (long chain) subunit )</html:p>
<html:p>SUBSYSTEM: acyl-CoA hydrolysis</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Saturated__45__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FRUCTOKINASE__45__RXN" name="Fructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( Hxk2 ) or (  ) or (  ) or (  ) or (  ) or ( scrK ) or (  ) or ( frk ) or ( mak ) or ( scrK ) or ( fruK ) or (  ) or ( HXK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructokinase-II ) or ( hexokinase ) or ( fructokinase ) or ( fructokinase-Ib ) or ( fructokinase-Ia ) or ( fructokinase ) or ( NA ) or ( fructose kinase ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( frucokinase I subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: sucrose degradation I</html:p>
<html:p>SUBSYSTEM: sucrose degradation IV</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R421__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( camA and camB and camC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P-450cam and NADH-putidaredoxin reductase and putidaredoxin )</html:p>
<html:p>SUBSYSTEM: adamantanone degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__743" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__744" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4511" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: glyceollin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.85</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4403" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4405" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4512" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: glyceollin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.85</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4404" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4406" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ndk ) or ( NME2 and NME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ndk ) or ( nucleoside diphosphate kinase B and nucleoside diphosphate kinase A )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4510" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: glyceollin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.36</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="_6AS11AS__45__36A9__45__TRIHYDROXYPTEROCARPAN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4404" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4513" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: glyceollin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.85</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4404" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4407" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTURONOKINASE__45__RXN" name="Galacturonokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-galacturonate biosynthesis II (from D-galacturonate)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.44</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__501" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PIPERIDINE__45__N__45__PIPEROYLTRANSFERASE__45__RXN" name="Piperidine N-piperoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: piperine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.145</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PIPERIDINE" stoichiometry="1"/>
      <speciesReference species="EE__45__PIPEROYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="N__45__EE__45__PIPEROYL__45__PIPERIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2625" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mutS and mutL and mutH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MutH and MutL and MutS )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8199" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8200" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHLBXANAU__45__RXN" name="2-haloacid dehalogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dhlB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DhlB )</html:p>
<html:p>SUBSYSTEM: 1,2-dichloroethane degradation</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROACETIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__99__46__16__45__RXN" name="Maltose &amp;alpha;-D-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( treS ) or ( treS ) or ( treS ) or ( treS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose synthase subunit ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROQUINATE__45__SYNTHASE__45__RXN" name="3-dehydroquinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aroB ) or ( aroB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2621" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( uvrA and uvrC and uvrB and uvrD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( excinuclease ABC, subunit C; repair of UV damage to DNA and excision nuclease subunit A and DNA repair; excision nuclease subunit B and DNA-dependent ATPase I and helicase II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.25-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8180" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8534" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2624" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ruvB and ruvA and ruvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Holliday junction nuclease; resolution of structures; repair and branch migration of Holliday structures; repair and branch migration of Holliday structures; repair helicase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.22.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__Combined__45__With__45__Exogenous__45__DNA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Resolution__45__of__45__Recombinational__45__Junction__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINEKIN__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( udk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOGLUTREDUCT__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-oxoglutarate reductase subunit )</html:p>
<html:p>SUBSYSTEM: glutamate degradation V (via hydroxyglutarate)</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.2</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__2__45__HYDROXYGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__90__45__RXN" name="Methanol--5-hydroxybenzimidazolylcobamide co-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mtaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.90</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__7162" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7163" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( CYP81E1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: glyceollin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.89</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DAIDZEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXYDAIDZEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYBENZOATE__45__3__45__MONOOXYGENASE__45__RXN" name="4-hydroxybenzoate 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pobA ) or ( pobA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: toluene degradation to protocatechuate (via p-cresol)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation III (aerobic) (via p-cresol)</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTSEMIALDEHYDROG__45__RXN" name="Glutamate-5-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( proA ) or ( ALDH18A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ProA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4509" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: glyceollin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.36</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6AS11AS__45__36A9__45__TRIHYDROXYPTEROCARPAN" stoichiometry="1"/>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4403" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4502" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: glyceollin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.51</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXYDAIDZEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXY__45__23__45__DIHYDRODAIDZEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4504" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: glyceollin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.246</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXY__45__23__45__DIHYDRODAIDZEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4402" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4505" name="3,9-dihydroxypterocarpan 6A-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP93A1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: glyceollin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.28</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4402" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6AS11AS__45__36A9__45__TRIHYDROXYPTEROCARPAN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGININE__45__2__45__MONOOXYGENASE__45__RXN" name="Arginine 2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: arginine degradation X (arginine monooxygenase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.12.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__GUANIDO__45__BUTYRAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__2__46__10__45__RXN" name="Phosphoglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glmM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSAMINE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSMANMUT__45__RXN" name="Phosphomannomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cpsG ) or ( manB ) or ( PH0923 ) or ( AT2G45790 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( phosphomannomutase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis I (L-galactose pathway)</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPRIBOSYLTRAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hpt ) or ( hpt ) or (  ) or (  ) or ( gpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine-guanine phosphoribosyltransferase ) or ( NA ) or ( NA ) or ( NA ) or ( Gpt )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_26DICHDIOX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pentachlorophenol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_26__45__DICHLORO__45__P__45__HYDROQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__CHLOROMALEYLACETATE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNOSE__45__ISOMERASE__45__RXN" name="Mannose isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yihS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannose isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__92__45__RXN" name="Sinapoylglucose--malate O-sinapoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( SNG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sinapate ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.92</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: MAL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
      <speciesReference species="_1__45__O__45__SINAPOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="SINAPOYL__45__S__45__MALATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R301__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glkA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-dependent glucokinase subunit )</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.147</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALYL__45__COA__45__LYASE__45__RXN" name="Malyl-CoA lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mclA ) or ( mcl1 ) or ( mclA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-malyl CoA lyase subunit ) or ( malyl-CoA lyase subunit ) or ( malyl coenzyme A lyase subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate cycle</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.24</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__208" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R501__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( stc2 and stc3 and stc4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative flavoprotein subunit of putatitve monooxygenase and putative oxygenase subunit of putatitve monooxygenase and putative reductase subunit of putatitve monooxygenase )</html:p>
<html:p>SUBSYSTEM: stachydrine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Methylated__45__methyl__45__acceptors__124__</html:p>
<html:p>SIDE: __124__Methyl__45__acceptors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Methyl__45__acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__821" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Methylated__45__methyl__45__acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__904" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__DEHYDROSPHINGANINE__45__REDUCTASE__45__RXN" name="3-dehydrosphinganine reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Kdsr ) or (  ) or ( TSC10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-ketodihydrosphingosine reductase ) or ( NA ) or ( 3-ketosphinganine reductase )</html:p>
<html:p>SUBSYSTEM: ceramide biosynthesis</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.102</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDROSPHINGANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLPCARB__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenyl phosphate carboxylase )</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: phenol degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENOL__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FARNESYLTRANSTRANSFERASE__45__RXN" name="geranylgeranyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GGPS6 ) or ( GGPS2 ) or ( sds1 ) or ( hbgg ) or ( BTS1 ) or ( hexs-b and hexs-a ) or (  ) or ( PDSS2 and PDSS1 ) or ( GGPPS ) or ( hepT and hepS ) or ( GGPS1 ) or ( ispB ) or ( GGPS4 ) or ( GGPS3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( solanesyl diphosphate synthase ) or ( NA ) or ( NA ) or ( hexaprenyl diphosphate synthase component A and hexaprenyl diphosphate synthase component B ) or ( solanesyl diphosphate synthase monomer ) or ( decaprenyl diphosphate synthase subunit 1 and decaprenyl diphosphate synthase subunit 2 ) or ( prenyltransferase subunit ) or ( heptaprenyl diphosphate synthase component 1 and heptaprenyl diphosphate synthase component 2 ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: geranylgeranyldiphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)</html:p>
<html:p>SUBSYSTEM: superpathway of plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: decaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: heptaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: nonaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: all trans undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: dodecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: tridecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.29</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__23__45__DIOXYGENASE__45__RXN" name="Tryptophan 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kynA ) or (  ) or ( BNA2 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan dioxygenase subunit ) or ( tryptophan dioxygenase subunit ) or ( NA ) or ( tryptophan dioxygenase subunit ) or ( tryptophan dioxygenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: tryptophan degradation I (via anthranilate)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.11</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMYLKYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTURIDYLYLTRANS__45__RXN" name="UDP-glucose--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( galT ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GalT ) or ( galactose 1-phosphate uridyl transferase )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R128__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__UREIDO__45__4__45__IMIDAZOLE_CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__5__45__IMIDAZOLE_CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MHPHYDROXY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mhpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYPHENYL__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__DIHYDROXYPHENYL__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__291__45__RXN" name="2-hydroxymethylglutarate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-(hydroxymethyl)glutarate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.291</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9437" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9438" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R546__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-oxo-&amp;Delta;3-4,5,5-trimethylcyclopentenyl acetyl coA 1,2-monooxygenase subunit )</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__867" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__868" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1941" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dkgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.274</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHYL__45__2__45__METHYLACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHYL__45__2R__45__METHYL__45__3S__45__HYDROXYBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5285" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( gudD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-glucarate dehydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1090" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( USP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-L-arabinose biosynthesis II (from L-arabinose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.37</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1825" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__L__45__ARABINOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5289" name="2-hydroxy-3-oxopropionate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( garR ) or ( glxR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( tartronate semialdehyde reductase 2 )</html:p>
<html:p>SUBSYSTEM: superpathway of glycol metabolism and degradation</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.60</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THRESYN__45__RXN" name="Threonine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( thrC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2364" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xsc ) or ( xsc ) or ( xsc ) or ( xsc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfoacetaldehyde acetyltransferase subunit ) or ( sulfoacetaldehyde acetyltransferase subunit ) or ( sulfoacetaldehyde acetyltransferase subunit ) or ( Xsc )</html:p>
<html:p>SUBSYSTEM: sulfoacetaldehyde degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of taurine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.15</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SULFOACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1001" name="3-phytase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( agp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( Agp )</html:p>
<html:p>SUBSYSTEM: phytate degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__534" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYGLUTAMATE__45__AMINOTRANSFERASE__45__RXN" name="4-hydroxyglutamate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.23</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__4__45__HYDROXY__45__2__45__KETO__45__GLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHDOGALDOL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kdgA ) or ( SSO224174 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-keto-3-deoxy-(6-phospho)-gluconate aldolase subunit ) or ( KDG-aldolase subunit )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5291" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ThDP adenylyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1095" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5292" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yfdR ) or ( yfbR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CPS-53 (KpLE1) prophage; deoxyribonucleoside 5&apos;-monophosphate phosphatase ) or ( dCMP phosphohydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5293" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yneI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5294" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-antigen ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__939" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1099" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1101" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5295" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bglB ) or ( ascB ) or ( bglA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phospho-&amp;beta;-glucosidase B; cryptic ) or ( 6-phospho-&amp;beta;-glucosidase; cryptic ) or ( 6-phospho-&amp;beta;-glucosidase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.86</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1162" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROQUINONE" stoichiometry="1"/>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__75__45__RXN" name="5-guanidino-2-oxopentanoate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aruI ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: arginine degradation VIII (arginine oxidase pathway)</html:p>
<html:p>SUBSYSTEM: arginine degradation IX (arginine:pyruvate transaminase pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.75</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__824" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__825" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__GLUCURONID__45__RXN" name="&amp;beta;-glucuronidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( uidA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-D-glucuronidase )</html:p>
<html:p>SUBSYSTEM: superpathway of hexuronide and hexuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide and D-glucuronate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.31</html:p>
<html:p>SIDE: __124__Alcohols__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__D__45__Glucuronides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5298" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fucU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-fucose mutarotase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10329" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R602__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dxnA2 and dxnA1 and dxnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dioxin dioxygenase &amp;alpha; subunit and dioxin dioxygenase &amp;beta; subunit and hydrolase subunit of dioxin dioxygenase )</html:p>
<html:p>SUBSYSTEM: dibenzo-p-dioxin degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__922" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__925" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5297" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bglB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phospho-&amp;beta;-glucosidase B; cryptic )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.86</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1181" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__173" stoichiometry="1"/>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDPHOSDEHYD__45__RXN" name="Imidazoleglycerol-phosphate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HISN5A ) or ( hisB ) or ( hisB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPPYPHOSKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( spoT ) or ( relA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.5</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE__45__5DP__45__3DP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLMALONYL__45__COA__45__MUT__45__RXN" name="Methylmalonyl-CoA mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mutA and mutB ) or (  ) or ( mcmA ) or ( scpA ) or ( Msed_0638 and Msed_2055 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonyl-CoA mutase large subunit and methylmalonyl-CoA mutase small subunit ) or ( NA ) or ( NA ) or ( NA ) or ( methylmalonyl-CoA mutase &amp;alpha; subunit and methylmalonyl-CoA mutase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: conversion of succinate to propionate</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: 2-oxobutanoate degradation I</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: glutamate degradation VIII (to propionate)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate cycle</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXYLATE__45__REDUCTASE__45__NADP__43____45__RXN" name="Glyoxylate reductase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ghrB ) or ( ghrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GhrB ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7441" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrazole synthase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-pyrazole-1-ylalanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PYRAZOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITRATE__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Isocitrate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IDH1 and IDH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate dehydrogenase [NAD] &amp;beta; subunit and isocitrate dehydrogenase [NAD] &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.41</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__17__45__RXN" name="Taxadiene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TDC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( taxadiene synthase )</html:p>
<html:p>SUBSYSTEM: taxol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.17</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAXA__45__411__45__DIENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7421" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SfCPA-FAS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cyclopropane and cyclopropene fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.79</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSTERCULIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOPRIBOTRANS__45__RXN" name="Nicotinate-nucleotide pyrophosphorylase (carboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At2g01350 ) or ( pTQPT1 ) or ( pRQPT1 ) or (  ) or ( BNA6 ) or ( nadC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( QPT subunit ) or ( NA ) or ( quinolinate phosphoribosyltransferase (decarboxylating) monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.19</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNREDUC__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ribD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.193</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1086" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHANETHIOL__45__OXIDASE__45__RXN" name="Methanethiol oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dimethylsulfide degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of dimethylsulfone degradation</html:p>
<html:p>PROTEIN_CLASS: 1.8.3.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7671" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALLATE__45__MUCONATE__45__TRANSFORMATION__45__RXN" name="Protocatechuate 4,5-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PmdB and PmdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protocatechuate 4,5-dioxygenase &amp;beta; subunit and protocatechuate 4,5-dioxygenase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: gallate degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__183" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__185" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAM__45__RXN" name="Phosphoserine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Psat1 ) or ( serC ) or ( PSAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase 1 ) or ( SerC ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__134__45__RXN" name="1D-myo-inositol-tetrakisphosphate 1-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ipk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myo-inositol polyphosphate kinase )</html:p>
<html:p>SUBSYSTEM: lipid-independent phytate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.134</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__178" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__458" name="PHS kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LCB4 ) or ( LCB5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.91</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHTYOSPHINGOSINE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOPROPANOL__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Isopropanol dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH1B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: acetone degradation I (to methylglyoxal)</html:p>
<html:p>SUBSYSTEM: acetone degradation II (to acetoacetate)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.80</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISO__45__PROPANOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5234" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GlyA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLO__45__THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Aldehyde dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALD6 ) or ( yqhD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( magnesium-activated aldehyde dehydrogenase, cytosolic ) or ( NADP-dependent dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.4</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKANAL__45__MONOOXYGENASE__45__FMN__45__LINKED__45__RXN" name="Alkanal monooxygenase (FMN-linked)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( luxA and luxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( luciferase &amp;alpha; chain and luciferase &amp;beta; chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.3</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Light__124__" stoichiometry="1"/>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5240" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GlyA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ARABINONOLACTONASE__45__RXN" name="L-arabinonolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( araB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.15</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__368" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1117" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALADEHYDCHLORO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dcyD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-cysteine desulfhydrase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.5.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIOGLYCOLATE" stoichiometry="1"/>
      <speciesReference species="_3__45__CHLORO__45__D__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__CARBOXYMETHYL__45__D__45__CYSTEINE" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSEPHOSPHA__45__RXN" name="Trehalose-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( otsB ) or ( yfbT ) or (  ) or ( ybiV ) or ( yigL ) or ( tps2 ) or ( yidA ) or ( otsB ) or ( treE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( sugar phosphatase ) or ( NA ) or ( sugar phosphatase ) or ( sugar phosphatase ) or ( trehalose-6-phosphate phosphatase ) or ( sugar phosphatase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis II</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis III</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETONE__45__CYANHYDRIN__45__LYASE__45__RXN" name="Acetone-cyanohydrin lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetone cyanohydrin lyase ) or ( acetone cyanohydrin lyase )</html:p>
<html:p>SUBSYSTEM: linamarin degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.37</html:p>
<html:p>SIDE: ACETONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXY__45__2__45__METHYLPROPANENITRILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCN" stoichiometry="1"/>
      <speciesReference species="ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3381" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yieF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chromate reductase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4762" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CR__43__3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R365__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pnbB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrobenzoate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.3.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: AMMONIUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__705" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
      <speciesReference species="AMMONIUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENACEOX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylacetyl-CoA:acceptor oxidoreductase subunit &amp;alpha; and phenylacetyl-CoA:acceptor oxidoreductase subunit &amp;beta; and phenylacetyl-CoA:acceptor oxidoreductase subunit &amp;gamma; )</html:p>
<html:p>SUBSYSTEM: phenylacetate degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>PROTEIN_CLASS: 1.17.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__207" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__" stoichiometry="4"/>
      <speciesReference species="PHENYLGLYOXYLATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5243" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( chbF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diacetylchitobiose-6-phosphate hydrolase )</html:p>
<html:p>SUBSYSTEM: chitobiose degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACETYLCHITOBIOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEAMINASE__45__RXN" name="AMP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMONITRO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mmoX and mmoY and mmoZ and mmoC and orfY and mmoB ) or ( amoC and amoB and amoA ) or (  ) or ( pmoA1 and pmoA2 and pmoB1 and pmoB2 and pmoC1 and pmoC2 and pmoC3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( soluble methane monooxygenase regulatory component and soluble methane monooxygenase MMOD component and soluble methane monooxygenase hydroxylase component &amp;gamma; subunit and soluble methane monooxygenase reductase component and soluble methane monooxygenase hydroxylase component &amp;alpha; subunit and soluble methane monooxygenase hydroxylase component &amp;beta; subunit ) or ( ammonia monooxygenase &amp;beta; subunit and ammonia monooxygenase &amp;alpha; subunit and ammonia monooxygenase &amp;gamma; subunit ) or ( ammonia monooxygenase &amp;beta; subunit and ammonia monooxygenase &amp;alpha; subunit ) or ( particulate methane monooxygenase hydroxylase component &amp;alpha; subunit and particulate methane monooxygenase hydroxylase component &amp;beta; subunit and particulate methane monooxygenase hydroxylase component &amp;gamma; subunit )</html:p>
<html:p>SUBSYSTEM: ammonia oxidation III</html:p>
<html:p>SUBSYSTEM: ammonia oxidation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="E__45__" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__32__45__RXN" name="Vomilenine reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.32</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VOMILENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_12__45__DIHYDROVOMILENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__703" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yiaK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-diketo-L-gulonate reductase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIKETO__45__L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETO__45__L__45__GULONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__704" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lyxK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-xylulose kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETO__45__L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2343" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__705" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sgbH ) or ( ulaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-keto-L-gulonate 6-phosphate decarboxylase ) or ( 3-keto-L-gulonate 6-phosphate decarboxylase )</html:p>
<html:p>SUBSYSTEM: L-ascorbate degradation, anaerobic</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.85</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2343" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__XYLULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__17__46__99__46__1__45__RXN" name="4-cresol dehydrogenase (hydroxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha; subunit of 4-cresol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: toluene degradation to protocatechuate (via p-cresol)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation III (aerobic) (via p-cresol)</html:p>
<html:p>PROTEIN_CLASS: 1.17.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXYBENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__70__45__RXN" name="Mannosyl-3-phosphoglycerate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mngB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.70</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__MANNOSYL__45__3__45__PHOSPHOGLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__O__45__ALPHA__45__MANNOSYL__45__D__45__GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOSULFATE__45__SULFURTRANSFERASE__45__RXN" name="Thiosulfate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pspE ) or (  ) or ( rhdA ) or ( glpE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( thiosulfite-cleaving enzyme subunit ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: thiosulfate disproportionation III (rhodanese)</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="1"/>
      <speciesReference species="HCN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="HSCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__GENERIC__45__RXN" name="alcohol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( adhE ) or ( ADH1 ) or ( ADH4 ) or ( ADH3 ) or ( adhP ) or ( adhE ) or ( ADH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AdhE ) or ( alcohol dehydrogenase I subunit ) or ( alcohol dehydrogenase IV subunit ) or ( alcohol dehydrogenase III subunit ) or ( NA ) or ( alcohol dehydrogenase ) or ( alcohol dehydrogenase II subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__45__Or__45__Ketones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_9__45__FLUORENOL__45__DEHYDROGENASE__45__RXN" name="Fluoren-9-ol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fluorene degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.256</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_9FLUORENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_9FLUORENONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACNEULY__45__RXN" name="N-acetylneuraminate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nanA ) or ( SSA_0078 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NanA ) or ( N-acetylneuraminate lyase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: N-acetylneuraminate and N-acetylmannosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYLNEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALPMUT__45__RXN" name="UDP-galactopyranose mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glf )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__D__45__GALACTO__45__14__45__FURANOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINA2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( linA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-hexachlorocyclohexane degradation</html:p>
<html:p>PROTEIN_CLASS: 4.5.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAMMA__45__PENTACHLOROCYCLOHEXANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__15" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBENZOATE__45__4__45__MONOOXYGENASE__45__RXN" name="3-hydroxybenzoate 4-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: m-cresol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.23</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARTRANSFORM__45__RXN" name="Phosphoribosylaminoimidazolecarboxamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade17 ) or ( purH ) or ( ade16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ade17 ) or ( NA ) or ( Ade16 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.3</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AICAR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__2__46__27__45__RXN" name="dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-L-dihydrostreptose:streatidine-6-phosphate dihydrostreptosyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.27</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: TDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__L__45__DIHYDROSTREPTOSE" stoichiometry="1"/>
      <speciesReference species="STREPTIDINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__14__45__ALPHA__45__L__45__DIHYDROSTREPTOSYL__45__STREPTID" stoichiometry="1"/>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__148__45__RXN" name="4-(cytidine 5&apos;-diphospho)-2-C-methyl-D-erythritol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( YchB ) or ( ispE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.148</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BAIAEUBSP__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( baiA2 ) or ( baiA1 ) or ( baiA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of 3&amp;alpha;-hydroxysteroid dehydrogenase 2 ) or ( subunit of 3&amp;alpha;-hydroxysteroid dehydrogenase 1 ) or ( subunit of 3&amp;alpha;-hydroxysteroid dehydrogenase 3 )</html:p>
<html:p>SUBSYSTEM: cholate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXO__45__CHOLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__1__46__107__45__RXN" name="3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal multifunctional enzyme type 2 subunit )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.107</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7243" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7275" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: naringenin glycoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.185</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NARINGENIN__45__7__45__O__45__BETA__45__D__45__GLUCOSIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__6__45__OHPHENOL__45__METHY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UbiG )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__METHOXYPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRNA__45__PSEUDOURIDINE__45__SYNTHASE__45__I__45__RXN" name="tRNA-pseudouridine synthase I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rluA ) or ( truB ) or ( truA ) or ( truD ) or ( truC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 23S rRNA and tRNA pseudouridine synthase ) or ( tRNA pseudouridine 55 synthase ) or ( tRNA pseudouridine synthase I ) or ( tRNA pseudouridine 13 synthase ) or ( tRNA pseudouridine 65 synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8538" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8537" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_ADP_COF_RXN" name="ATP_TO_ADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCISOM__45__RXN" name="Glucose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PGI1 ) or (  ) or ( pgi ) or ( pgi ) or ( pgi ) or (  ) or ( pgiA ) or ( fruI ) or (  ) or ( TM1385 ) or ( GPIS ) or ( PGI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglucoisomerase subunit ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( phosphoglucose isomerase subunit ) or ( phosphoglucose isomerase subunit ) or ( NA ) or ( phosphoglucose isomerase subunit ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: sucrose degradation IV</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis I</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TECH1REDHAL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PcpC )</html:p>
<html:p>SUBSYSTEM: pentachlorophenol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>SIDE: OXIDIZED__45__GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
      <speciesReference species="TETRACHLOROHYDROQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="_236__45__TRICHLOROHYDROQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( boxB and boxA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative benzoyl-CoA oxygenase component B and putative benzoyl-CoA oxygenase component A subunit )</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYCLOHEX__45__13__45__DIENE__45__56__45__DIHYDROXY__45__1__45__CARBO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYKI__45__RXN" name="Thymidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tdk ) or ( tdk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__26__45__RXN" name="Deacetoxycephalosporin-C hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CEFEF ) or ( cefF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deacetoxycephalosporin C synthase / deacetoxycephalosporin C hydroxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of penicillin, cephalosporin and cephamycin biosynthesis</html:p>
<html:p>SUBSYSTEM: deacetylcephalosporin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.26</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEACETOXYCEPHALOSPORIN__45__C" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEACETYLCEPHALOSPORIN__45__C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITSYN__45__RXN" name="Citrate (si)-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gltA2 ) or ( HP0026 ) or (  ) or ( prpC ) or ( CS ) or ( gltA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( citrate synthase (gltA) ) or ( NA ) or ( NA ) or ( citrate synthase, mitochondrial precursor ) or ( citrate synthase monomer )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7488" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate)</html:p>
<html:p>SUBSYSTEM: superpathway of tetrahydroxyxanthone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_3__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__264" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5200" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( avtA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="__124__Amineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3686" stoichiometry="1"/>
      <speciesReference species="__124__Deamineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7487" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate)</html:p>
<html:p>SUBSYSTEM: superpathway of tetrahydroxyxanthone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6882" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6886" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5209" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lysU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysyl-tRNA synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE5TRIPHOSPHO5ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5208" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lysU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysyl-tRNA synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__P4" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHHB__45__METHYLTRANSFER__45__RXN" name="3-demethylubiquinone-9 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UbiG )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__OH__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9956" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBITOL__45__2__45__DEHYDROGENASE__45__RXN" name="ribitol 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rtlA ) or ( rbtD ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ribitol dehydrogenase subunit ) or ( ribitol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: ribitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.56</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_7KAPSYN__45__RXN" name="8-amino-7-oxononanoate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bioF ) or ( bioF ) or ( bioF ) or ( AtbioF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 8-amino-7-oxononanoate synthase monomer ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis III</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.47</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CPD__45__558</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_8__45__AMINO__45__7__45__OXONONANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__23__45__DIOXYGENASE__45__RXN" name="Catechol 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( xylE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( subunit of catechol 2,3-dioxygenase )</html:p>
<html:p>SUBSYSTEM: catechol degradation I (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: catechol degradation II (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation IV (aerobic) (via catechol)</html:p>
<html:p>SUBSYSTEM: catechol degradation to 2-oxopent-4-enoate II</html:p>
<html:p>SUBSYSTEM: catechol degradation to 2-oxopent-4-enoate I</html:p>
<html:p>SUBSYSTEM: meta cleavage pathway of aromatic compounds</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMUCONATE__45__SALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GALACTOSE_TO_UDP_COF_RXN" name="UDP-GALACTOSE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R122__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( atzB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: atrazine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ETHANAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYATRAZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANAMINE" stoichiometry="1"/>
      <speciesReference species="N__45__ISOPROPYLAMMELIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__SORBITOL__45__DEHYDROGENASE__45__RXN" name="D-sorbitol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sldA and sldB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-sorbitol dehydrogenase large subunit and D-sorbitol dehydrogenase small subunit )</html:p>
<html:p>SUBSYSTEM: 2-keto-L-gulonate biosynthesis</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.21</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9569" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIP__45__KIN__45__RXN" name="Nucleoside-diphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ndk ) or ( NME2 and NME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ndk ) or ( nucleoside diphosphate kinase B and nucleoside diphosphate kinase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__101__45__RXN" name="Formylmethanofuran--tetrahydromethanopterin N-formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ftr ) or ( ftr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ftr ) or ( NA )</html:p>
<html:p>SUBSYSTEM: methanogenesis from CO2</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.101</html:p>
<html:p>SIDE: THMPT</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THMPT" stoichiometry="1"/>
      <speciesReference species="__124__Formyl__45__methanofurans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THMPT" stoichiometry="1"/>
      <speciesReference species="__124__Methanofurans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5223" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yegS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipid kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5225" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( amiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anhydro-N-acetylmuramoyl-L-alanine amidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1080" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1082" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDGLUTSYN__45__RXN" name="2-hydroxyglutarate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( menD ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.11</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXYGLUTARIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Serine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sgaA ) or ( sgaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine-glyoxylate aminotransferase subunit ) or ( serine-glyoxylate aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R221__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( alkJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: octane oxidation</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTANOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__371" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5228" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ycjG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-Ala-D/L-Glu epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALA__45__GAMMA__45__D__45__GLU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1445" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__46__45__RXN" name="Diaminobutyrate--pyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ectB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( EctB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__470" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEHYDROGENASE__45__ACCEPTOR__45__RXN" name="Malate dehydrogenase (acceptor)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mqo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TIGLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ECHS1 ) or ( ech )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( short chain enoyl-CoA hydratase subunit ) or ( enoyl-CoA hydratase subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: 2-methylbutyrate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__159__45__RXN" name="Acridone synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AIG ) or ( Acs2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: acridone alkaloid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.159</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__METHYLANTHRANILOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_13__45__DIHYDROXY__45__N__45__METHYLACRIDONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__138__45__RXN" name="Methylarsonite methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AS3MT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.137</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLARSONITE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYLARSINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5210" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( wbbI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-1,6-galactofuranosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1048" stoichiometry="1"/>
      <speciesReference species="UDP__45__D__45__GALACTO__45__14__45__FURANOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1049" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__69__45__RXN" name="5-hydroxyfuranocoumarin 5-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AmBMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: linear furonocoumarin biosynthesis II</html:p>
<html:p>SUBSYSTEM: linear furanocoumarin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.69</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BERGAPTOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHOXYFURANOCOUMARIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5214" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ulaG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphodiesterase / predicted L-ascorbate 6-phosphate lactonase )</html:p>
<html:p>SUBSYSTEM: L-ascorbate degradation, anaerobic</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASCORBATE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2343" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5213" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ydjG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylglyoxal reductase (NADH-dependent) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5216" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mngB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-mannosidase )</html:p>
<html:p>SUBSYSTEM: 2-O-&amp;alpha;-mannosyl-D-glycerate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1063" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5217" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( speE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SpeE )</html:p>
<html:p>SUBSYSTEM: aminopropylcadaverine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: _5__45__METHYLTHIOADENOSINE</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CADAVERINE" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1065" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TCCOL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tsaB and tsaM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-toluene-sulfonate monooxygenase reductase subunit and TsaM )</html:p>
<html:p>SUBSYSTEM: 4-toluenecarboxylate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__TOLUENECARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__CARBOXYBENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: linamarin degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINAMARIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXY__45__2__45__METHYLPROPANENITRILE" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLISOM__45__RXN" name="Xylose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( XylA ) or ( D-xylose isomerase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: xylose degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEHYDOGLUCONOKINASE__45__RXN" name="Dehydogluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__339" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCONDEHYDRAT__45__RXN" name="Phosphogluconate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( edd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8134" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G25980 ) or ( AT5G26000 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( myrosinase ) or ( myrosinase and myrosinase )</html:p>
<html:p>SUBSYSTEM: glucosinolate breakdown</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.147</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ALPHA__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glucosinolates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIOHYDROXIMATE__45__O__45__SULFATES" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEPHOSPHORYLATION__45__RXN" name="5&apos;-nucleotidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( surE ) or (  ) or ( yjjG ) or ( nagD ) or ( ushA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( broad specificity 5&apos;(3&apos;)-nucleotidase and polyphosphatase ) or ( 5&apos;-nucleotidase ) or ( pyrimidine nucleotidase ) or ( ribonucleotide monophosphatase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2PTERIDINEPYROPHOSPHOKIN__45__RXN" name="2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Y08611 ) or ( folK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( HPPK/DHPS subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROPTERIN__45__CH2OH__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDPGALDOL__45__RXN" name="2-dehydro-3-deoxyphosphogluconate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kdgA ) or ( eda ) or ( TM0066 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-keto-3-deoxy-(6-phospho)-gluconate aldolase subunit ) or ( Eda ) or ( NA )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway I</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__2__46__27__45__RXN" name="Aerobactin synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( iucA and iucC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aerobactin synthase &amp;alpha; subunit and aerobactin synthase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: aerobactin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.27</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CIT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
      <speciesReference species="CPD__45__961" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AEROBACTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7442" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrazole synthase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-pyrazole-1-ylalanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRAZOLIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PYRAZOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAPHTHALENE__45__12__45__DIOXYGENASE__45__RXN" name="Naphthalene 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahAa and nahAb and nahAd and nahAc ) or ( tecA4 and tecA2 and tecA3 and tecA1 ) or ( nbzAa and nbzAc and nbzAb and nbzAd ) or ( ndoA and ndoR and ndoC and ndoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha; subunit of naphthalene 1,2-dioxygenase terminal oxygenase and naphthalene 1,2-dioxygenase terminal oxygenase &amp;beta; subunit and naphthalene 1,2-dioxygenase component A and naphthalene 1,2-dioxygenase component C ) or ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit ) or ( oxygenaseNBZ&amp;alpha; and ferredoxinNBZ and oxygenaseNBZ&amp;beta; and reductaseNBZ ) or ( naphthalene 1,2-dioxygenase &amp;beta; subunit and naphthalene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component and naphthalene 1,2-dioxygenase &amp;alpha; subunit and naphthalene 1,2-dioxygenase system ferredoxin subunit )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAPHTHALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__12__45__DIHYDRONAPHTHALENE__45__12__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7443" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrazole synthase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-pyrazole-1-ylalanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRAZOLIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHAGALACTOSID__45__RXN" name="&amp;alpha;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( galA ) or ( melA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GalA ) or ( &amp;alpha;-galactosidase monomer )</html:p>
<html:p>SUBSYSTEM: melibiose degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MELIBIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mimosine synthase )</html:p>
<html:p>SUBSYSTEM: mimosine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.52</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: ACETYLSERINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXYPIRIDIN__45__CPD" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MIMOSINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETRAACYLDISACC4KIN__45__RXN" name="Tetraacyldisaccharide 4&apos;-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lpxK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.130</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BISOHMYR__45__GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPID__45__IV__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALARACECAT__45__RXN" name="Alanine racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( alr ) or ( dadX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alanine racemase 1, PLP-binding, biosynthetic ) or ( NA )</html:p>
<html:p>SUBSYSTEM: alanine degradation I</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMANDELONITRILE__45__LYASE__45__RXN" name="Hydroxymandelonitrile lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HNL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dhurrin degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.11</html:p>
<html:p>SIDE: _4__45__HYDROXYBENZALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__648" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXYBENZALDEHYDE" stoichiometry="1"/>
      <speciesReference species="HCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: alliin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9293" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9295" stoichiometry="1"/>
      <speciesReference species="CPD__45__9296" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8905" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: alliin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9298" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9269" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8909" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALLACA1 ) or ( cysteine sulfoxide lyase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: isoalliin degradation</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9307" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9304" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__26__45__RXN" name="&amp;beta;-fructofuranosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( scrB ) or ( scrB ) or ( scrB ) or ( scrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sucrose degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.26</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTASE__45__RXN" name="Aspartate ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aspA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AspA )</html:p>
<html:p>SUBSYSTEM: glutamate degradation II</html:p>
<html:p>SUBSYSTEM: superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine.</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: alliin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9275" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9293" stoichiometry="1"/>
      <speciesReference species="CPD__45__9273" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8900" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: alliin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9273" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9275" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTDEAM__45__RXN" name="Cytosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( codA ) or ( codA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( creatinine deiminase subunit )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8916" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( alliinase ) or ( cysteine sulfoxide lyase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ethiin degradation</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9280" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9311" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPIONYL__45__COA__45__CARBOXY__45__RXN" name="Propionyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( pccA and pccB ) or ( Msed_1375 and Msed_0147 and Msed_0148 ) or ( pccB and accC and accB ) or ( Pcca and Pccb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( propionyl-CoA carboxylase &amp;alpha; subunit and propionyl-CoA carboxylase &amp;beta; subunit ) or ( acyl CoA carboxylase biotin carboxyl carrier protein subunit and acyl CoA carboxylase biotin carboxylase subunit and acyl CoA carboxylase carboxyltransferase subunit ) or ( acyl CoA carboxylase carboxyltransferase subunit and acyl CoA carboxylase biotin carboxyl carrier protein subunit and acyl CoA carboxylase biotin carboxylase subunit ) or ( propionyl-CoA carboxylase &amp;alpha; subunit and propionyl-CoA carboxylase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: 2-oxobutanoate degradation I</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate cycle</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8915" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ethiin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9300" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9280" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALANINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Alanine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AGX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alanine--glyoxylate aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.44</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8912" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: isoalliin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9304" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9306" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R23__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( icd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxalosuccinate reductase subunit )</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPOTAURINE__45__DEHYDROGENASE__45__RXN" name="Hypotaurine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: taurine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOTAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8911" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lfs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isoalliin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9304" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9305" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8910" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isoalliin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9298" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9307" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8106" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fpoF and fpoI and fpoC and fpoD and fpoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( F420H2 dehydrogenase subunit FpoD and F420H2 dehydrogenase subunit FpoB and F420H2 dehydrogenase subunit FpoC and F420H2 dehydrogenase subunit FpoI and F420H2 dehydrogenase subunit FpoF )</html:p>
<html:p>SUBSYSTEM: coenzyme B/coenzyme M regeneration</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Oxidized__45__Factor__45__F420__124__</html:p>
<html:p>SIDE: __124__Reduced__45__Factor__45__F420__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Reduced__45__Factor__45__F420__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__7323" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Oxidized__45__Factor__45__F420__124__" stoichiometry="1"/>
      <speciesReference species="DIHYDROMETHANOPHENAZINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7481" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AF352395 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BPS subunit )</html:p>
<html:p>SUBSYSTEM: tetrahydroxyxanthone biosynthesis (from benzoate)</html:p>
<html:p>SUBSYSTEM: superpathway of tetrahydroxyxanthone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.151</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__140__45__RXN" name="1D-myo-inositol-tetrakisphosphate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPK2&amp;alpha; ) or ( IPK2&amp;beta; )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3)</html:p>
<html:p>SUBSYSTEM: superpathway of lipid-dependent phytate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.140</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__505" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7483" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydroxyxanthone biosynthesis (from benzoate)</html:p>
<html:p>SUBSYSTEM: superpathway of tetrahydroxyxanthone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2346__45__TETRAHYDROXYBENZOPHENONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6883" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7482" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydroxyxanthone biosynthesis (from benzoate)</html:p>
<html:p>SUBSYSTEM: superpathway of tetrahydroxyxanthone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2346__45__TETRAHYDROXYBENZOPHENONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7485" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydroxyxanthone biosynthesis (from benzoate)</html:p>
<html:p>SUBSYSTEM: superpathway of tetrahydroxyxanthone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6883" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6884" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7484" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate)</html:p>
<html:p>SUBSYSTEM: superpathway of tetrahydroxyxanthone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2346__45__TETRAHYDROXYBENZOPHENONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6882" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOPROPDEHYDROG__45__RXN" name="(R)-aminopropanol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gldA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GldA )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: aminopropanol biosynthesis</html:p>
<html:p>SUBSYSTEM: aminopropanol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.75</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__AMINO__45__PROPAN__45__2__45__OL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__114__45__RXN" name="Hexaprenyldihydroxybenzoate methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-6 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.114</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HEXAPRENYL__45__45__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HEXAPRENYL__45__4__45__HYDROXY__45__5__45__METHOXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ERYTHRON4PDEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.290</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ERYTHRONATE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3OH__45__4P__45__OH__45__ALPHA__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYMETVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ilvD ) or ( ilvDD ) or ( ilvD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihidroxy acid dehydratase subunit ) or ( dihydroxy-acid dehydratase subunit ) or ( IlvD )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I (from threonine)</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8925" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pAMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: capsaicin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Amineated__45__Amine__45__Donors__124__</html:p>
<html:p>SIDE: __124__Deamineated__45__Amine__45__Donors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VANILLIN" stoichiometry="1"/>
      <speciesReference species="__124__Amineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9327" stoichiometry="1"/>
      <speciesReference species="__124__Deamineated__45__Amine__45__Donors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__10__46__1__45__RXN" name="Receptor protein-tyrosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( etk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( autophosphorylating protein tyrosine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.10.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8927" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( csy1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: capsaicin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9327" stoichiometry="1"/>
      <speciesReference species="CPD__45__9329" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAPSAICIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5302" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5061" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5062" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3902" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( gcdH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8920" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LePGT-1 ) or ( LePGT-2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: shikonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9318" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8922" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: shikonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9319" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9320" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPNACETYLGLUCOSAMENOLPYRTRANS__45__RXN" name="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( murA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.7</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN4FS__45__13" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTC2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-L-galactose phosphorylase )</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis IV (extended VTC2 cycle)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: GLC__45__1__45__P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__L__45__GALACTOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPDQT__45__4" stoichiometry="1"/>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8169" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HGT8 ) or ( PF3R4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: shisonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__766" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7138" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: apigenin glycosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.236</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APIGENIN__45__7__45__O__45__BETA__45__D__45__GLUCOSIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APIGENIN__45__7__45__O__45__NEOHESPERIDOSIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN4FS__45__11" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis II (L-gulose pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8930" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( atzE ) or ( atzF ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( allophanate hydrolase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cyanurate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.84</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__809" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__578" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN4FS__45__12" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTC2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-L-galactose phosphorylase )</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis III (VTC2 cycle)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__L__45__GALACTOSE" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPDQT__45__4" stoichiometry="1"/>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8931" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( eafar )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: farnesene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9338" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NACGLCTRANS__45__RXN" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( murG ) or ( murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C5" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__99__46__30__45__RXN" name="Carotene 7,8-desaturase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ZDS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;zeta;-CAROTENE DESATURASE )</html:p>
<html:p>SUBSYSTEM: trans-lycopene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.30</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NEUROSPORENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__114" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8936" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PTR2 ) or ( PTR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: vestitol and sativan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3402" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9366" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMEOSYN__45__RXN" name="heme o biosynthesis" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cyoE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEME_O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8939" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc11 ) or ( (+)-germacrene D synthase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: germacrene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9370" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCDEHYDROG__45__RXN" name="Phosphoglycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PGDH ) or ( Phgdh ) or ( serA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 3-phosphoglycerate dehydrogenase subunit ) or ( SerA )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.95</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTCYSLIG__45__RXN" name="Glutamate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSH1 ) or ( gshA ) or ( Gclm and Gclc ) or ( GCLC and GCLM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( glutamate--cysteine ligase regulatory subunit and glutamate--cysteine ligase catalytic subunit ) or ( glutamate--cysteine ligase catalytic subunit and glutamate--cysteine ligase regulatory subunit )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLSERINE__45__ALDOLASE__45__RXN" name="Phenylserine aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ltaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( LtaA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__644" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADH__45__P__45__OR__45__NOP_TO_NAD__45__P__45__OR__45__NOP_COF_RXN" name="NADH-P-OR-NOP_TO_NAD-P-OR-NOP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__DECARBOXYLASE__45__RXN" name="Tyrosine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TYDC1 ) or ( TYDC2 ) or ( mfnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( L-tyrosine decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid tyramine amides biosynthesis</html:p>
<html:p>SUBSYSTEM: methanofuran biosynthesis</html:p>
<html:p>SUBSYSTEM: (S)-reticuline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.25</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYRAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8170" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PfAT208 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: shisonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: P__45__COUMAROYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7138" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7714" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8172" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>SUBSYSTEM: lysine degradation VII</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__6__45__AMINO__45__CAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8171" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ss5MaT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: shisonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.172</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7714" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7708" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8174" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: sulfur oxidation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfide oxidation (Acidithiobacillus ferrooxidans)</html:p>
<html:p>SUBSYSTEM: sulfur oxidation II (Fe+3-dependent)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Thiols__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S8" stoichiometry="1"/>
      <speciesReference species="__124__Thiols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Perthiols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8173" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation IX</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>SUBSYSTEM: lysine degradation VI</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7682" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8176" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dusky ) or ( Ip3GGT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: anthocyanidin sophoroside metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__766" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7842" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8175" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of sulfide oxidation (Starkeya novella)</html:p>
<html:p>SUBSYSTEM: sulfide oxidation IV (sulfur dioxygenase)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Thiols__124__</html:p>
<html:p>SIDE: __124__Disulfides__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="__124__Disulfides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Perthiols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Thiols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLESTERASE__45__RXN" name="acetic-ester acetylhydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aes )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acetic__45__Esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8178" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dusky ) or ( Ip3GGT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: anthocyanidin sophoroside metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7117" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7844" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENIIISYN__45__RXN" name="uroporphyrinogen-III synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hemD ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.75</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8177" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dusky ) or ( Ip3GGT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: anthocyanidin sophoroside metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PELARGONIDIN__45__3__45__GLUCOSIDE__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7843" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8940" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ipuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isopropylamine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="ISOPROPYLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9372" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1104" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At5g20230 ) or ( OMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: free phenylpropanoid acid biosynthesis</html:p>
<html:p>SUBSYSTEM: suberin biosynthesis</html:p>
<html:p>SUBSYSTEM: simple coumarins biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.68</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CAFFEATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8941" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ipuB and ipuA and ipuD and ipuE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferredoxin and cytochrome P450 and ferredoxin and NAD(P)H-dependent ferredoxin reductase )</html:p>
<html:p>SUBSYSTEM: isopropylamine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9372" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9373" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1103" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At1g74550 ) or ( REF8 ) or ( At1g74540 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( p-coumaroyl shikimate/quinate 3&apos;-hydroxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: free phenylpropanoid acid biosynthesis</html:p>
<html:p>SUBSYSTEM: suberin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COUMARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAFFEATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4606" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtST5a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( desulfoglucosinolate sulfotransferase )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from phenylalanine</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.-</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PAP</html:p>
<html:p>SIDE: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZYL__45__DESULFOGLUCOSINOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZYL__45__GLUCOSINOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1106" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CCR1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cinnamoyl coenzyme A reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: capsiconiate biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.44</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FERULOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CONIFERYL__45__ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4605" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G24100 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UGT74B1 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from phenylalanine</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.195</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLACETOTHIOHYDROXIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZYL__45__DESULFOGLUCOSINOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETHYDPICSUCC__45__RXN" name="2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dapD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tetrahydrodipicolinate succinylase subunit )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.117</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__SUCCINYL__45__2__45__AMINO__45__6__45__KETOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1105" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 4CL1 ) or ( 4CL3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-coumarate coenzyme A ligase ) or ( 4-coumarate coenzyme A ligase )</html:p>
<html:p>SUBSYSTEM: suberin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.12</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FERULOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBINPGUANYLYLTRANS__45__RXN" name="Adenosylcobinamide-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobP ) or ( cobU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CobP ) or ( adenosylcobinamide-phosphate guanylyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.62</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8945" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ipuI ) or ( ipuH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: isopropylamine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9375" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4603" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At4g31500 ) or ( At4g13770 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYP83B1 ) or ( CYP83A1 )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from phenylalanine</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="PHENYLACETALDOXIME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7545" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATEREDUCT__45__RXN" name="Dihydrofolate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHFR-TS ) or (  ) or ( folA ) or ( folA ) or ( folM ) or ( dyrA ) or ( THY-1 ) or ( THY-2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( DHFR-TS subunit ) or ( NA ) or ( dihydrofolate reductase ) or ( NA ) or ( DyrA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8942" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ipuF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isopropylamine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9373" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="CPD__45__9374" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4602" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G05260 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYP79A2 )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from phenylalanine</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLACETALDOXIME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R__45__2__45__METHYLMALATE__45__DEHYDRATASE__45__RXN" name="(R)-2-methylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( leuC and leuD ) or ( leuD and leuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopropylmalate isomerase small subunit and isopropylmalate isomerase large subunit ) or ( isopropylmalate isomerase large subunit and isopropylmalate isomerase small subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.35</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__31" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYLMALEATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8948" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( carA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbapenam synthetase subunit )</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9369" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9371" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8949" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( carC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbapenem synthase subunit )</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9371" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9377" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R307__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: resorcinol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__623" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8130" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__118__45__RXN" name="N-hydroxyarylamine O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nhoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NhoA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.118</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Hydroxy__45__Arylamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__N__45__Acetoxy__45__Arylamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8946" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ipuI ) or ( ipuH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: isopropylamine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__665" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8947" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( carB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carboxymethylproline synthase subunit )</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9369" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__11__45__RXN" name="Glycogen (starch) synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GYS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen synthase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.11</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtCAD4 ) or ( AtCAD5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cinnamyl alcohol dehydrogenase ) or ( cinnamyl alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.195</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COUMARALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COUMARYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINSYNDEAM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ribD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.26</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM__45__RXN" name="Deoxycytidine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cdd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cdd )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.14</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8162" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( amaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.31</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7682" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PIPOX ) or ( amaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__PIPECOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7682" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHAALPHA__45__TREHALOSE__45__PHOSPHORYLASE__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AB079610 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose phosphorylase subunit ) or ( trehalose phosphorylase subunit ) or ( trehalose phosphorylase subunit ) or ( trehalose phosphorylase subunit )</html:p>
<html:p>SUBSYSTEM: trehalose degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.64</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__448" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__45____45__LIMONENE__45__3__45__MONOOXYGENASE__45__RXN" name="(-)-limonene 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PM17 ) or ( PM2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (-)-limonene-3-hydroxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.47</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4886" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__263" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPIONATE__45__COA__45__TRANSFERASE__45__RXN" name="Propionate CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pct )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2-methylbutyrate biosynthesis</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate II (acrylate pathway)</html:p>
<html:p>SUBSYSTEM: L-alanine fermentation to propionate and acetate</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.1</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8166" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dpkA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PIPECOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8953" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfbE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-4-dehydro-6-deoxy-D-mannose-4-aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: GDP-&amp;alpha;-D-perosamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9387" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8954" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( colD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-4-keto-6-deoxy-D-mannose-3-dehydrase subunit )</html:p>
<html:p>SUBSYSTEM: GDP-L-colitose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9392" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8955" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( colC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-L-collitose synthase subunit )</html:p>
<html:p>SUBSYSTEM: GDP-L-colitose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9392" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9391" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9679" name="Glycine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GSDMT monomer )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis V (from glycine)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.162</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8956" name="Arginine--pyruvate transaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aruH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-arginine:pyruvate transaminase subunit )</html:p>
<html:p>SUBSYSTEM: arginine degradation IX (arginine:pyruvate transaminase pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.84</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__824" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8950" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( carC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbapenem synthase subunit )</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9371" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9376" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNPOXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PdxH )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8957" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ccr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( crotonyl-CoA carboxylase/reductase )</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADPH" stoichiometry="1"/>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADPH" stoichiometry="1"/>
      <speciesReference species="CPD__45__9406" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9684" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PEN1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: arabidiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10307" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9685" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BARS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: baruol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10308" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8153" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: phaseic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7234" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8155" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73B1 ) or ( UGT75B1 ) or ( UGT71B6 ) or ( UGT75B2 ) or ( UGT84B2 ) or ( UGT84B1 ) or ( AOG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: abscisic acid glucose ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__693" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7727" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9680" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GSDMT monomer )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis V (from glycine)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.162</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R303__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nfsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADPH nitroreductase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.-.-.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nitroaromatic__45__Ox__45__Compounds__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nitroaromatic__45__Red__45__Compounds__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gua1 ) or ( guaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( GMP synthetase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: guanosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.2</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9669" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 ) or ( FAD2 ) or ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;omega;-6 fatty acid desaturase, endoplasmic reticulum ) or ( fatty acid &amp;Delta;12 desaturase, chloroplastic )</html:p>
<html:p>SUBSYSTEM: linoleate biosynthesis I (plants)</html:p>
<html:p>PROTEIN_CLASS: 1.14.19.6</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Oleoyl__45__groups__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Linoleoyl__45__groups__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8966" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sct )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl-CoA:R-citramalate coenzyme A transferase subunit )</html:p>
<html:p>SUBSYSTEM: glyoxylate assimilation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__31" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9414" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8967" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ccl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( R-citramalyl-CoA lyase subunit )</html:p>
<html:p>SUBSYSTEM: glyoxylate assimilation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9414" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8139" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ss5MaT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvianin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7142" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8964" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( smtA and smtB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl CoA:L-malate CoA transferase &amp;alpha; subunit and succinyl CoA:L-malate CoA transferase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate cycle</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: CPD__45__8904</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
      <speciesReference species="CPD__45__8904" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__208" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3943" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: indole-3-acetate degradation to anthranilate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIOXINDOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISATIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8137" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G54040 ) or ( ESP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glucosinolate breakdown</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIOHYDROXIMATE__45__O__45__SULFATES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPITHIONITRILES" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: costunolide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8743" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9411" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8138" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PfAT208 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvianin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CAFFEOYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CAFFEOYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7137" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7140" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3944" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: indole-3-acetate degradation to anthranilate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISATIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__AMINOPHENYL__45__GLYOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1125" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtCAD5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cinnamyl alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.195</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SINAPALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SINAPYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9664" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MRN1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: marneral biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10285" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9667" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 ) or ( FAD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( &amp;omega;-3 fatty acid desaturase monomer )</html:p>
<html:p>SUBSYSTEM: &amp;alpha;-linolenate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.19.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Linoleoyl__45__groups__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alpha__45__linolenoyl__45__groups__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8135" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: glucosinolate breakdown</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIOHYDROXIMATE__45__O__45__SULFATES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOTHIOCYANATES" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8960" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mch )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glyoxylate assimilation</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9408" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9409" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9666" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACOT4 ) or ( ACOT1 ) or ( ACOT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase 4, proxisomal ) or ( acyl-CoA thioesterase 1, cytosolic ) or ( acyl-CoA thioesterase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: oleate biosynthesis II (animals)</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OLEOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8136" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G54040 ) or ( ESP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glucosinolate breakdown</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIOHYDROXIMATE__45__O__45__SULFATES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nitriles__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8961" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mclA ) or ( mcl1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-malyl CoA lyase subunit ) or ( malyl-CoA lyase subunit )</html:p>
<html:p>SUBSYSTEM: glyoxylate assimilation</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9409" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1122" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-coumarate coenzyme A ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.12</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_5__45__HYDROXY__45__FERULIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__HYDROXY__45__FERULOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1121" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAH1 ) or ( At5g04330 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferulate 5-hydroxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: free phenylpropanoid acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__HYDROXY__45__FERULIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1124" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cinnamoyl coenzyme A reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SINAPOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="SINAPALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1123" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__HYDROXY__45__FERULOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SINAPOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R282__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aliB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AliB )</html:p>
<html:p>SUBSYSTEM: cyclohexane-1-carboxylate degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__577" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__533" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8969" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sesquiterpene dehydrogenase )</html:p>
<html:p>SUBSYSTEM: costunolide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9411" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9412" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__1983" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoaconitase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.36</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FMNH2_TO_FMN_COF_RXN" name="FMNH2_TO_FMN_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FMNH2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__PPENTOMUT__45__RXN" name="Phosphopentomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( deoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleosides degradation</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9671" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mraY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__UDP__45__NAcMur__45__Peptides__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="__124__NAcMur__45__Peptide__45__Undecaprenols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8970" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sesquiterpene dehydrogenase )</html:p>
<html:p>SUBSYSTEM: costunolide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9412" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9413" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9672" name="Undecaprenyldiphospho-muramoylpentapeptide &amp;beta;-N- acetylglucosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( murG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.227</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__NAcMur__45__Peptide__45__Undecaprenols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__NAcMur__45__Peptide__45__NAcGlc__45__Undecaprenols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8144" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: morphine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_7__45__O__45__ACETYLSALUTARIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__7710" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9673" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACSL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( long-chain-fatty-acid--CoA ligase 1 )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-linolenate biosynthesis II (animals)</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__18" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9674" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BGD2 ) or ( BGD4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lotaustralin degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10277" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10276" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUERCETIN__45__3__45__O__45__METHYLTRANSFERASE__45__RXN" name="Quercetin 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methylquercetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.76</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__520" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3457__45__TETRAHYDROXY__45__3__45__METHOXYFLAVONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: morphine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__RETICULINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_12__45__DEHYDRORETICULINIUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8141" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4G04870 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARDIOLIPIN" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2PGADEHYDRAT__45__RXN" name="Phosphopyruvate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( eno ) or ( eno ) or ( eno ) or ( eno ) or (  ) or (  ) or ( LOC2 ) or (  ) or ( eno ) or ( eno ) or ( ENO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( enolase subunit ) or ( enolase subunit ) or ( Eno ) or ( enolase ) or ( Eno ) or ( NA ) or ( enolase ) or ( enolase ) or ( enolase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: glycolysis IV (plant cytosol)</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMKALT__45__RXN" name="T2-induced deoxynucleotide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( gmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gmk )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOKIN__45__RXN" name="Gluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( gntK ) or ( idnK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( GntK ) or ( gluconokinase II )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>SUBSYSTEM: L-idonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8979" name="2-methylcitrate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acnD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__622" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9421" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZYL__45__ALCOHOL__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: m-cresol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OH__45__BENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OH__45__BENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8971" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: costunolide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9413" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9410" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8974" name="3-hydroxypropionate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malonyl CoA reductase subunit ) or ( malonate semialdehyde reductase (NADPH) )</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate assimilation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8975" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mraY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: CPD__45__9646</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C3" stoichiometry="1"/>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C4" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8977" name="2-methylaconitate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( prpF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitate isomerase subunit )</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9421" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1136" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRUVATE__45__REDUCTASE__45__RXN" name="Hydroxypyruvate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hprA ) or ( hprA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxypyruvate reductase subunit ) or ( hydroxypyruvate reductase subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.81</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8980" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-coniciene and coniine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9422" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="CPD__45__9423" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8981" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-coniciene and coniine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9423" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9424" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__27__45__RXN" name="Methylmalonate-semialdehyde dehydrogenase (acylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dntE ) or ( mmsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonate-semialdehyde dehydrogenase subunit ) or ( methylmalonate-semialdehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>SUBSYSTEM: 2,4-dinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.27</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE__45__6__45__PHOSPHATE__45__REDUCTASE__45__NADPH__45__RXN" name="Aldose-6-phosphate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( A6PR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldose-6-phosphate reductase subunit )</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.200</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__SORBITOL__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R212__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksD ) or ( aksE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__152" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__153" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferulate 5-hydroxylase )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>SUBSYSTEM: ferulate and sinapate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CONIFERYL__45__ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__HYDROXY__45__CONIFERALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__RIBULOKIN__45__RXN" name="D-ribulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rtlB ) or ( rbtK ) or ( darK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( D-ribulokinase subunit ) or ( DarK )</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation II</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: ribitol degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.47</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3962" name="6-aminohexanoate linear dimer hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nylB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-aminohexanoate linear dimer hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: nylon-6 oligomer degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.46</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__6__45__AMINOHEXANOYL__45__6__45__AMINOHEXANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__884" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1143" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( OMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>SUBSYSTEM: ferulate and sinapate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.68</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__HYDROXY__45__CONIFERALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SINAPALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3961" name="6-aminohexanoate cyclic dimer hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nylA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-aminohexanoate cyclic dimer subunit )</html:p>
<html:p>SUBSYSTEM: nylon-6 oligomer degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3921" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__6__45__AMINOHEXANOYL__45__6__45__AMINOHEXANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1144" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FAH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferulate 5-hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CONIFERYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__HYDROXY__45__CONIFERYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9643" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lotaustralin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of linamarin and lotaustralin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.63</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10276" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10277" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9644" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACSL1 ) or ( LACS9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( long-chain-fatty-acid--CoA ligase 1 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: linoleate biosynthesis I (plants)</html:p>
<html:p>SUBSYSTEM: linoleate biosynthesis II (animals)</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OLEOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8983" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-coniciene and coniine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9425" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9426" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3963" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nylC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-aminohexanoate oligomer hydrolase polypeptide I and 6-aminohexanoate oligomer hydrolase polypeptide II )</html:p>
<html:p>SUBSYSTEM: nylon-6 oligomer degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3923" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__6__45__AMINOHEXANOYL__45__6__45__AMINOHEXANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8982" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-coniciene and coniine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9424" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9425" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9646" name="3-oxoacyl-[acyl-carrier protein] synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ELOVL6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( long chain fatty acid elongase 6 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LAUROYLCOA__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10284" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPRODEHYDROG__45__RXN" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__4__45__HYDROXY__45__PROLINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9647" name="3-oxoacyl-[acyl-carrier protein] synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ELOVL6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( long chain fatty acid elongase 6 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRADECANOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXOPALMITOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8988" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl-CoA synthetase )</html:p>
<html:p>SUBSYSTEM: itaconate degradation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.4</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ITACONATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1137" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__15__45__RXN" name="Cholinephosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT2G32260 ) or ( PCT2 ) or (  ) or ( LOC_Os02g07720.1 ) or ( PCT1 ) or ( AT4G15130 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline-phosphate cytidylyltransferase ) or ( NA ) or ( cholinephosphate cytidylyltransferase subunit ) or ( choline-phosphate cytidylyltransferase B, putative, expressed ) or ( NA ) or ( choline-phosphate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.15</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8987" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: itaconate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.7</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
      <speciesReference species="ITACONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="CPD__45__1137" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R544__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__865" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__866" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UREA__45__CARBOXYLASE__45__RXN" name="Urea carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DUR1,2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( urea amidolyase )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation in yeast</html:p>
<html:p>SUBSYSTEM: urea degradation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__578" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__2__45__3__45__DIOXYGENASE__45__RXN" name="catechol 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tomB ) or (  ) or ( todE ) or ( tbuE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate I (via o-cresol)</html:p>
<html:p>SUBSYSTEM: toluene degradation V (aerobic) (via toluene-cis-diol)</html:p>
<html:p>SUBSYSTEM: 2-nitrotoluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation I (aerobic) (via o-cresol)</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate (via toluene-cis-diol)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__111" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2H6OH2__45__4DIENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UTPHEXPURIDYLYLTRANS__45__RXN" name="UTP--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( galT ) or ( galT ) or (  ) or ( USP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-galactose pyrophosphorylase ) or ( GalT ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.10</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8991" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( leuC and leuD ) or ( leuC and leuD ) or ( leuD and leuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopropylmalate isomerase small subunit and isopropylmalate isomerase large subunit ) or ( LeuC and LeuD ) or ( isopropylmalate isomerase large subunit and isopropylmalate isomerase small subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9451" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8992" name="all-trans-octaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDSS2 and PDSS1 ) or ( sds1 ) or ( ispB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decaprenyl diphosphate synthase subunit 1 and decaprenyl diphosphate synthase subunit 2 ) or ( solanesyl diphosphate synthase ) or ( NA ) or ( solanesyl diphosphate synthase monomer )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: decaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: all trans undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: dodecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: nonaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: tridecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.11</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8990" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAAS ) or ( PAAS ) or ( AADC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYSYN__45__RXN" name="phosphatidate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4G26770 ) or ( AT5G58560 ) or ( CDS2 ) or ( LOC_Os10g17990.1 ) or ( LOC_Os01g55360.1 ) or ( AT3G60620 ) or ( LOC_Os01g61560.1 ) or ( LOC_Os02g05320.1 ) or ( LOC_Os02g03460.1 ) or ( VTE5 ) or ( AT4G22340 ) or ( AT3G45040 ) or ( LOC_Os04g57500.1 ) or ( LOC_Os01g52864.1 ) or ( AT1G62430 ) or ( CDS1 ) or ( LOC_Os12g01480.1 ) or ( cdsA ) or ( AT2G45150 ) or ( LOC_Os11g01450.1 ) or (  ) or ( LOC_Os02g05400.1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidate cytidylyltransferase ) or ( phosphatidate cytidylyltransferase ) or ( phosphatidate cytidylyltransferase 2 ) or ( phosphatidate cytidylyltransferase, putative, expressed ) or ( phosphatidate cytidylyltransferase, putative, expressed ) or ( phosphatidate cytidylyltransferase ) or ( phytol kinase 2, chloroplast precursor, putative, expressed ) or ( phosphatidate cytidylyltransferase, putative, expressed ) or ( phosphatidate cytidylyltransferase, putative, expressed ) or ( NA ) or ( phosphatidate cytidylyltransferase ) or ( dolichol kinase ) or ( phytol kinase 1, chloroplast precursor, putative, expressed ) or ( uncharacterized conserved membrane protein, putative, expressed ) or ( NA ) or ( phosphatidate cytidylyltransferase 1 ) or ( phytol kinase 2, chloroplast precursor, putative, expressed ) or ( NA ) or ( phosphatidate cytidylyltransferase ) or ( phytol kinase 2, chloroplast precursor, putative, expressed ) or ( NA ) or ( phosphatidate cytidylyltransferase, putative )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis I (plastid)</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.41</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3082" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AmAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aureusidin synthase )</html:p>
<html:p>SUBSYSTEM: aurone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.21.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APIGENIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2982" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERONE__45__KINASE__45__RXN" name="Glycerone kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DAK ) or ( dhaK ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxyacetone kinase subunit ) or ( dihydroxyacetone kinase subunit ) or ( dihydroxyacetone kinase subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: glycerol degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.29</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPNACETYLMURAMATEDEHYDROG__45__RXN" name="UDP-N-acetylmuramate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( murB ) or ( murB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylenolpyruvoylglucosamine reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.158</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__ACETYL__45__CARBOXYVINYL__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__10__45__RXN" name="2,6-dihydroxypyridine 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: nicotine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.10</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__123" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2301" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9637" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( THAD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: thalianol and derivatives biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Thalian__45__diols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Desaturated__45__Thalian__45__diols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9638" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP79D2 ) or ( CYP79D3 ) or ( CYP79D4 ) or ( CYP79D1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( valine N-monooxygenase )</html:p>
<html:p>SUBSYSTEM: lotaustralin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of linamarin and lotaustralin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10271" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10272" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8997" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of undecaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9454" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9453" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9636" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP79D2 ) or ( CYP79D3 ) or ( CYP79D4 ) or ( CYP79D1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( valine N-monooxygenase )</html:p>
<html:p>SUBSYSTEM: lotaustralin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of linamarin and lotaustralin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10271" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TOLUENE__45__2__45__MONOOXYGENASE__45__RXN" name="toluene-2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tomA3 and tomA4 and tomA1 and tomA2 and tomA5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( toluene ortho-monooxygenase TomA5 subunit and toluene ortho-monooxygenase TomA2 subunit and toluene ortho-monooxygenase hydroxylase TomA3 subunit and toluene ortho-monooxygenase hydroxylase TomA1 subunit and toluene ortho-monooxygenase hydroxylase TomA4 subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate I (via o-cresol)</html:p>
<html:p>SUBSYSTEM: toluene degradation I (aerobic) (via o-cresol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TOLUENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__109" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8994" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of undecaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9457" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9456" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8993" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of undecaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9457" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AROMATIC__45__L__45__AMINO__45__ACID__45__DECARBOXYLASE__45__RXN" name="Aromatic-L-amino-acid decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TDC ) or (  ) or ( DDC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan decarboxylase subunit ) or ( NA ) or ( aromatic-L-amino-acid decarboxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: beta-carboline biosynthesis</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid serotonin amides biosynthesis</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VI (via tryptamine)</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9631" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( THAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: thalianol and derivatives biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10263" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Thalian__45__diols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8996" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of undecaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9455" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9454" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__LYASE__45__RXN" name="Cystathionine &amp;beta;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( metC ) or ( CBL1 ) or ( malY ) or ( STR3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MetC ) or ( cystathionine &amp;beta;-lyase ) or ( bifunctional: repressor of maltose regulon ) or ( NA )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8995" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of undecaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9456" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9455" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8197" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( G10H )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7857" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8193" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Keto1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: canthaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7853" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7854" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8194" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Keto1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: canthaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__129" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7856" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8195" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Keto1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: canthaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7856" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7854" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERMBARK__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mer )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mer )</html:p>
<html:p>SUBSYSTEM: methyl-coenzyme M oxidation to CO2</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.-</html:p>
<html:p>SIDE: __124__Reduced__45__Factor__45__F420__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9" stoichiometry="1"/>
      <speciesReference species="__124__Oxidized__45__Factor__45__F420__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10" stoichiometry="1"/>
      <speciesReference species="__124__Reduced__45__Factor__45__F420__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__129__45__RXN" name="Peptidoglycan glycosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mrcB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MrcB )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.129</html:p>
<html:p>SIDE: UNDECAPRENYL__45__DIPHOSPHATE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7695" stoichiometry="1"/>
      <speciesReference species="__124__Peptidoglycans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="__124__Peptidoglycans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8196" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: canthaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7854" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7851" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8190" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtW148 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: astaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7852" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7847" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__REDUCT__45__RXN" name="Sulfite reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cysJ and cysI ) or ( met5 and met10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfite reductase flavoprotein subunit and sulfite reductase hemoprotein subunit ) or ( &amp;alpha; subunit and &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (by sulfhydrylation)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8192" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Keto1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: canthaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__129" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7853" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9628" name="Palmitoyl-CoA hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACOT4 ) or ( ACOT1 ) or ( ACOT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase 4, proxisomal ) or ( acyl-CoA thioesterase 1, cytosolic ) or ( acyl-CoA thioesterase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10267" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3617" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__LYASE__45__RXN" name="Hydroxymethylglutaryl-CoA lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mvaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>SUBSYSTEM: mevalonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.4</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9629" name="Palmitoyl-CoA hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yciA ) or ( ACOT4 ) or (  ) or ( CESdD1 ) or ( ACOT1 ) or ( ACOT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase ) or ( acyl-CoA thioesterase 4, proxisomal ) or ( lll ) or ( acyl-coA hydrolase (long chain) subunit ) or ( acyl-CoA thioesterase 1, cytosolic ) or ( acyl-CoA thioesterase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9965" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="ARACHIDIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4121" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hinT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphoramidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.9.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP__45__LYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9624" name="Acyl-CoA hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACOT4 ) or ( ACOT1 ) or ( ACOT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase 4, proxisomal ) or ( acyl-CoA thioesterase 1, cytosolic ) or ( acyl-CoA thioesterase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: stearate biosynthesis I (animals)</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="STEAROYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="STEARIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9626" name="Palmitoyl-CoA hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACOT4 ) or ( ACOT1 ) or ( ACOT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase 4, proxisomal ) or ( acyl-CoA thioesterase 1, cytosolic ) or ( acyl-CoA thioesterase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRADECANOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__7836" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9627" name="Palmitoyl-CoA hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACOT4 ) or ( ACOT1 ) or ( ACOT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA thioesterase 4, proxisomal ) or ( acyl-CoA thioesterase 1, cytosolic ) or ( acyl-CoA thioesterase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LAUROYLCOA__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="DODECANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R242__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__503" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__508" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SEDOHEPTULOSE__45__BISPHOSPHATASE__45__RXN" name="Sedoheptulose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.37</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__1__45__7__45__P2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8179" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TNMT ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.122</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__STYLOPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7846" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8189" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtW148 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: astaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__130" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7852" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8186" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: astaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7851" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7849" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9630" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( THAS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: thalianol and derivatives biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10263" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8187" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: astaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7849" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7847" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8184" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtS ) or ( crtW148 ) or ( crtW38 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: astaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__129" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7850" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8185" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtS ) or ( crtW148 ) or ( crtW38 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: astaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7850" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7851" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( davD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.20</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__280" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.12</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROMACARPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7848" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8180" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.37</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7846" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2582" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( xthA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.21.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8533" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8532" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__HYDROXYPROTOPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSANGUINARINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2581" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nfo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( endonuclease IV )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.21.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__AP__45__Site__45__Created__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8532" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TOLUENE__45__3__45__MONOOXYGENASE__45__RXN" name="toluene-3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tbuB and tbuV and tbuA2 and tbuA1 and tbuC and tbuU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( toluene 3-monooxygenase ferredoxin subunit and toluene 3-monooxygenase hydroxylase &amp;gamma; subunit and toluene 3-monooxygenase hydroxylase &amp;beta; subunit and toluene 3-monooxygenase effector subunit and toluene 3-monooxygenase reductase subunit and toluene 3-monooxygenase hydroxylase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate (via 4-methylcatechol)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation II (aerobic) (via 4-methylcatechol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TOLUENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCINYLBENZOATE__45__COA__45__SYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( menC ) or ( menC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis II (plants)</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.113</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9923" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYLBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITRAMALYL__45__COA__45__LYASE__45__RXN" name="Citramalyl-CoA lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of citramalyl-S-ACP lyase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: itaconate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__627" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP__45__CITRATE__45__PRO__45__S__45____45__LYASE__45__RXN" name="ATP-citrate (pro-S-)-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACLA-1 and ACLB-2 ) or ( aclA and aclB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP-citrate lyase and ATP-citrate lyase ) or ( ATP citrate synthase &amp;alpha; subunit and ATP citrate synthase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of acetyl-CoA biosynthesis</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle I</html:p>
<html:p>SUBSYSTEM: acetyl-CoA biosynthesis (from citrate)</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GST__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( gst ) or ( yfcF ) or ( yfcG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gst ) or ( glutathione S-transferase ) or ( glutathione S-transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__CHLORO__45__24__45__DINITROBENZENE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="S__45__24__45__DINITROPHENYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSINE__45__RACEMASE__45__RXN" name="Lysine racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__219" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDHDEHYDROG__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH2 ) or ( ALD2 ) or ( ALD4 ) or ( ALD5 ) or ( alkH ) or ( ALD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase class 2 subunit ) or ( NA ) or ( potassium-activated aldehyde dehydrogenase, mitochondrial ) or ( aldehyde dehydrogenase, mitochondrial ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4861" name="Copalyl diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Iso ) or ( gg-agi ) or ( TPS-LAS ) or ( TPS-LAS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abietadiene synthase ) or ( abietadiene synthase ) or ( levopimaradiene/abietadiene synthase ) or ( levopimaradiene/abietadiene synthase )</html:p>
<html:p>SUBSYSTEM: neoabietic acid biosynthesis</html:p>
<html:p>SUBSYSTEM: isopimaric acid biosynthesis</html:p>
<html:p>SUBSYSTEM: palustric acid biosynthesis</html:p>
<html:p>SUBSYSTEM: dehydroabietic acid biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: abietic acid biosynthesis</html:p>
<html:p>SUBSYSTEM: levopimaric acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4750" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEXENEDIOATE__45__AUTOTRANSFORMATION__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>SUBSYSTEM: methylgallate degradation</html:p>
<html:p>SUBSYSTEM: gallate degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__185" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LOX2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipoxygenase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 13-LOX and 13-HPL pathway</html:p>
<html:p>SUBSYSTEM: jasmonic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.12</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLENIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R15__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tyrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Tyrosine aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: dimethylsulfoniopropionate biosynthesis III (algae)</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.5</html:p>
<html:p>SIDE: __124__Keto__45__Acid__124__</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="__124__Keto__45__Acid__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRAISOM__45__RXN" name="Phosphoribosylanthranilate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trpF ) or ( trpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylanthranilate isomerase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.24</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__NH3__45__RXN" name="GMP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( guaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GMP synthetase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: guanosine nucleotides de novo biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLGLUCOSAMINE__45__KINASE__45__RXN" name="N-acetylglucosamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nagK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetyl-D-glucosamine kinase )</html:p>
<html:p>SUBSYSTEM: chitobiose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.59</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1842" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pagP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PagP monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phospholipids__124__" stoichiometry="1"/>
      <speciesReference species="KDO2__45__LIPID__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__45__GLYCEROL__45__ESTER" stoichiometry="1"/>
      <speciesReference species="HEPTA__45__ACYLATED__45__LIPID__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__3__46__36__45__RXN" name="(S)-canadine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP719A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: berberine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__TETRAHYDROCOLUMBAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__TETRAHYDROBERBERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCGLUALDDEHYD__45__RXN" name="Succinylglutamate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( astD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: arginine degradation II (AST pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.71</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__SUCCINYLGLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__121__45__RXN" name="indole-3-acetate &amp;beta;-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( iaglu ) or ( UGT84B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IAA-glucose synthase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: IAA conjugate biosynthesis I</html:p>
<html:p>SUBSYSTEM: IAA conjugate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.121</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1102" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLESTANETRIOL__45__26__45__MONOOXYGENASE__45__RXN" name="Cholestanetriol 26-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdxr and Cyp27a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 27A1 and NA )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.15</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__BETA__45__CHOLESTANE__45__3__45__ALPHA7__45__ALPHA12__45__ALP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__BETA__45__CHOLESTANE__45__3__45__ALPHA7__45__TETRAOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTRACE__45__RXN" name="Glutamate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( murI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MurI )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLHOMOSER__45__CYS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( metY ) or ( met17 ) or (  ) or ( metY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( Met17 ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: homocysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (by sulfhydrylation)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.49</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPYROPHOSPHAT__45__RXN" name="NAD+ pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nudC ) or ( pnuE ) or ( NPY1 ) or (  ) or ( nadN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH pyrophosphatase ) or ( NA ) or ( NADH pyrophosphatase 1 ) or ( NA ) or ( NAD pyrophosphatase )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling (plants)</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.22</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__128__45__RXN" name="(R,S)-norcoclaurine 6-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSOMT2 ) or ( D29811 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( norcoclaurine 6-O-methyltransferase ) or ( norcoclaurine 6-O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: (S)-reticuline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.128</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__NORCOCLAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__COCLAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6201" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G58220 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( OHCU decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: urate degradation to allantoin</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5821" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ALLANTOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fadA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ethylbenzene degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOYL__45__ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( apc3 and apc4 and apc1 and apc2 and apc5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetophenone carboxylase subunit and acetophenone carboxylase subunit and acetophenone carboxylase subunit and acetophenone carboxylase subunit and acetophenone carboxylase subunit )</html:p>
<html:p>SUBSYSTEM: ethylbenzene degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYL__45__ACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bal )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ethylbenzene degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="BENZOYL__45__ACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYL__45__ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1301" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ebdB and ebdC and ebdA ) or ( ebdA and ebdC and ebdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( EBDC subunit and EBDB subunit and EBDA subunit ) or ( &amp;alpha; subunit of ethylbenzene dehydrogenase and &amp;gamma; subunit of ethylbenzene dehydrogenase and &amp;beta; subunit of ethylbenzene dehydrogenase )</html:p>
<html:p>SUBSYSTEM: ethylbenzene degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.17.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHYLBENZENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__1__45__PHENYLETHANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TERDCD__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tphA1 and tphA2 and tphA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( terephthalate 1,2-dioxygenase oxygenase component &amp;alpha; subunit and terephthalate 1,2-dioxygenase reductase component and terephthalate 1,2-dioxygenase oxygenase component &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: 4-toluenecarboxylate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TEREPHTHALATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__14__45__DICARBOXY__45__35__45__CYCLOHEXDIENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1302" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ped )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-phenylethanol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: ethylbenzene degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__1__45__PHENYLETHANOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4881" name="ent-cassa-12,15-diene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DTC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: diterpene phytoalexins precursors biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.28</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ENT__45__COPALYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4751" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4882" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DTC2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: diterpene phytoalexins precursors biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.33</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8719" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4752" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4883" name="syn-pimara-7,15-diene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DTS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: diterpene phytoalexins precursors biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.35</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8719" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4754" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4884" name="ent-sandaracopimaradiene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( KS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: diterpene phytoalexins precursors biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.29</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ENT__45__COPALYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4753" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1861" name="UDP-L-Ara4N formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( arnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused UDP-L-Ara4N formyltransferase and UDP-GlcA C-4&apos;&apos;-decarboxylase )</html:p>
<html:p>SUBSYSTEM: biosynthesis of  4-amino-4-deoxy-L-arabinose-modified lipid A</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__BETA__45__L__45__THREO__45__PENTAPYRANOSYL__45__4__45__ULOSE__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__4355" name="3-oxoacyl-[acyl-carrier protein] synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( accD5 ) or ( accD4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( propionyl-coa carboxylase beta chain 5 ) or ( propionyl-CoA carboxylase beta chain 4 )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.3</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__277" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__332" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__43____45__NEOMENTHOL__45__DEHYDROGENASE__45__RXN" name="(+)-neomenthol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MMR ) or ( MNR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( menthol dehydrogenase ) or ( neomenthol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.208</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1909" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1905" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1862" name="UDP-L-Ara4N formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( arnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused UDP-L-Ara4N formyltransferase and UDP-GlcA C-4&apos;&apos;-decarboxylase )</html:p>
<html:p>SUBSYSTEM: biosynthesis of  4-amino-4-deoxy-L-arabinose-modified lipid A</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.-</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__4__45__AMINO__45__4__45__DEOXY__45__L__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__L__45__ARA4__45__FORMYL__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1863" name="UDP-L-Ara4O C-4\&quot; transaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( arnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: biosynthesis of  4-amino-4-deoxy-L-arabinose-modified lipid A</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.-</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__BETA__45__L__45__THREO__45__PENTAPYRANOSYL__45__4__45__ULOSE__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__4__45__AMINO__45__4__45__DEOXY__45__L__45__ARABINOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R146__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( masB ) or ( ARD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aci-reductone dioxygenase ) or ( acireductone dioxygenase subunit )</html:p>
<html:p>SUBSYSTEM: methylthiopropionate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.53</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__MONOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
      <speciesReference species="CPD__45__7672" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYHEPTA__45__DIENEDIOATE__45__HYDROXY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hpcG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxyhepta-2,4-dienedioate hydratase subunit )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__787" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__804" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URPHOS__45__RXN" name="Uridine phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( udp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Udp )</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AGMATIN__45__RXN" name="Agmatinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( speB ) or ( speB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SpeB ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine degradation III (arginine decarboxylase/agmatinase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AGMATHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTODEXGLUCOSID__45__RXN" name="&amp;alpha;-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( malZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MTRMBARK__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: (  ) or (  )</html:p>
<html:p>SUBSYSTEM: methanogenesis from acetate</html:p>
<html:p>SUBSYSTEM: methyl-coenzyme M oxidation to CO2</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CPD__45__8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8" stoichiometry="1"/>
      <speciesReference species="__124__Me__45__CoM__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__CoM__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDP__45__GLUCOSE__45__46__45__DEHYDRATASE__45__RXN" name="CDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ascB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-D-glucose-4,6-dehydratase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.45</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__658" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZALDEHYDE__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Benzaldehyde dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdlD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: mandelate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOSINEKIN__45__RXN" name="Inosine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( gsk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.73</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYL__45__GLYOXAL__45__DEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation VII</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4157" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase II )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.58</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__1__45__DEHYDROGENASE__45__RXN" name="Glucose 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gdh ) or ( gdh ) or ( Ta0897 ) or ( gdh ) or ( gdhIV ) or ( gdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose dehydrogenase subunit ) or ( glucose dehydrogenase subunit ) or ( glucose dehydrogenase subunit ) or ( glucose dehydrogenase subunit ) or ( GlcDH-IV ) or ( glcDH )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.47</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNITOL__45__1__45__PHOSPHATASE__45__RXN" name="Mannitol-1-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: mannitol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNITOL__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLOROMUCISOM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbD ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase )</html:p>
<html:p>SUBSYSTEM: 1,4-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_25__45__DICHLORO__45__CISCIS__45__MUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CL__45__" stoichiometry="1"/>
      <speciesReference species="TRANS__45__2__45__CHLORO__45__4__45__CARBOXYMETHYLENEBUT__45__2__45__E" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXY__45__OXOHEPT__45__ENEDIOATE__45__DECARBOXY__45__RXN" name="5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hpaG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.68</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__785" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__787" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__34__45__RXN" name="Hydroxymethylglutaryl-CoA reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HMGCR ) or ( HMG2 ) or ( HMG1 ) or ( HMG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl-coenzyme A reductase ) or ( HMG-CoA reductase 2 ) or ( HMG-CoA reductase 1 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHIONINE__45__S__45__METHYLTRANSFERASE__45__RXN" name="Methionine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G49810 ) or ( MMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( methionine S-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: S-methylmethionine cycle</html:p>
<html:p>SUBSYSTEM: dimethylsulfoniopropionate biosynthesis II (Spartina)</html:p>
<html:p>SUBSYSTEM: dimethylsulfoniopropionate biosynthesis I (Wollastonia)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.12</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__397" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__AMINOPHENOL__45__OXIDASE__45__RXN" name="O-aminophenol oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( griF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINOPHENOL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOPHENOXAZINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANIDINOBUTANAMIDE__45__NH3__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: arginine degradation X (arginine monooxygenase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__GUANIDO__45__BUTYRAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__592" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2945" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cueO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multicopper oxidase with role in copper homeostasis )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.16.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CU__43__" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CU__43__2" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOX__45__RXN" name="Sarcosine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( soxD and soxG and soxB and soxA ) or (  ) or ( soxA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sarcosine oxidase &amp;gamma; subunit and sarcosine oxidase &amp;delta; subunit and sarcosine oxidase &amp;alpha; subunit and sarcosine oxidase &amp;beta; subunit ) or ( sarcosine oxidase large subunit and sarcosine oxidase small subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: creatinine degradation II</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADOMET__45__DMK__45__METHYLTRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase and S-adenosylmethionine:2-DMK methyltransferase )</html:p>
<html:p>SUBSYSTEM: menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEMETHYLMENAQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VITAMIN_K_2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2941" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mcrC and mcrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MrcC subunit of 5-methylcytosine restriction system and MrcB subunit of 5-methylcytosine restriction system )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.21.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__With__45__Recognition__45__Site__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Cleaved__45__DNA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2942" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mcrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( restriction of DNA at 5-methylcytosine residues )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.21.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__With__45__Recognition__45__Site__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__DNA__45__Cleaved__45__Recognition__45__Site__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2943" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cueO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multicopper oxidase with role in copper homeostasis )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__CARBOXYMUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZOATE__45____45__COA__45__LIGASE__45__RXN" name="Benzoate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( badA ) or (  ) or ( GI:23664434 ) or ( bzda ) or (  ) or ( bcla ) or ( AT1G65880 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( benzoate-CoA ligase subunit ) or ( benzoate-CoA ligase subunit ) or ( NA ) or ( benzoate-CoA ligase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: benzoate degradation II (aerobic and anaerobic)</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from homomethionine</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: tetrahydroxyxanthone biosynthesis (from benzoate)</html:p>
<html:p>SUBSYSTEM: superpathway of tetrahydroxyxanthone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.25</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OXAMATE__45__CARBAMOYLTRANSFERASE__45__RXN" name="Oxamate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: allantoin degradation IV (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.5</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__389" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="OXAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALLATE__45__1__45__BETA__45__GLUCOSYLTRANSFERASE__45__RXN" name="Gallate 1-&amp;beta;-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: pentagalloylglucose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.136</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__183" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DLACTDEHYDROGNAD__45__RXN" name="D-lactate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( ldhD ) or ( D-ldh ) or ( ldhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-lactate dehydrogenase subunit ) or ( D-lactate dehydrogenase subunit ) or ( D-lactate dehydrogenase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: alanine degradation II (to D-lactate)</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate II (acrylate pathway)</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>SUBSYSTEM: L-alanine fermentation to propionate and acetate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.28</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__86__45__RXN" name="Tetrahydromethanopterin S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mtrA and mtrB and mtrC and mtrD and mtrE and mtrH and mtrG and mtrF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MtrA subunit and MtrC subunit and MtrE subunit and MtrG subunit and MtrD subunit and MtrH subunit and MtrF subunit and MtrB subunit )</html:p>
<html:p>SUBSYSTEM: methanogenesis from CO2</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.86</html:p>
<html:p>SIDE: THMPT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__THMPT" stoichiometry="1"/>
      <speciesReference species="__124__CoM__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THMPT" stoichiometry="1"/>
      <speciesReference species="__124__Me__45__CoM__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" name="L-ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3761" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( CYP81E9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.52</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIOCHANIN__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3622" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3762" name="Isoflavone 3&apos;-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( CYP81E9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: rotenoid biosynthesis</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: maackiain biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.52</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMONONETIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9539" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3763" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: maackiain biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9539" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3628" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATE__45__REDUCTASE__45__NADPORNOPH__45__RXN" name="Nitrate reductase (NAD(P)H)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nasC and nasA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrate reductase small subunit and nitrate reductase large subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4022" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( queF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADPH-dependent nitrile oxidoreductase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_7__45__CYANO__45__7__45__DEAZAGUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__AMINOMETHYL__45__7__45__DEAZAGUANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3765" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP81E3 ) or ( CYP81E7 ) or ( CYP81E1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: maackiain biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.53</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3628" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3629" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3766" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( IFR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: maackiain biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.45</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3629" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3630" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3768" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: maackiain biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.246</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3630" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3631" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__6__46__1__46__11__45__RXN" name="(+)-&amp;delta;-cadinene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAD1-C1 ) or ( f-&amp;delta;sel1 ) or ( CAD1-A )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;delta;-selinene synthase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gossypol biosynthesis</html:p>
<html:p>SUBSYSTEM: lacinilene C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.13</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1722" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R503__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diketodeoxyinositol hydrolase )</html:p>
<html:p>SUBSYSTEM: myo-inositol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1133" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__827" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__2__46__38__45__RXN" name="Glycoprotein 2-&amp;beta;-D-xylosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( XylT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.38</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12" stoichiometry="1"/>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__X" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( folC ) or ( folC ) or (  ) or ( folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpoly-&amp;gamma;-synthetase subunit ) or ( NA ) or ( folylpoly-&amp;alpha;-glutamate synthetase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__254__45__RXN" name="(S)-carnitine 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-carnitine dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-butyrobetaine degradation</html:p>
<html:p>SUBSYSTEM: carnitine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.254</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DE__45__H__45__CARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IGPSYN__45__RXN" name="indole-3-glycerol-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trpC ) or ( trpC ) or ( trpC ) or ( trpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indole-3-glycerol phosphate synthase ) or ( indole-3-glycerol phosphate synthase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.48</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBOXYPHENYLAMINO__45__DEOXYRIBULOSE__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R364__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pnbA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrobenzoate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__704" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__705" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MOXXANAU__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 10 kDa polypeptide and 2-chloroethanol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: 1,2-dichloroethane degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__CHLOROETHANOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLOROACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__METHYLCITRATE__45__DEHYDRATASE__45__RXN" name="2-methylcitrate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( prpD ) or ( prpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.79</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__622" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1136" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UGD__45__RXN" name="UDP-glucose 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ugdh ) or ( ADH2 ) or ( ugd ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose dehydrogenase ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-D-xylose biosynthesis</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis VI</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4113" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH5 ) or ( ADH1 ) or ( ADH4 ) or ( ADH3 ) or ( ADH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase V subunit ) or ( alcohol dehydrogenase I subunit ) or ( alcohol dehydrogenase IV subunit ) or ( alcohol dehydrogenase III subunit ) or ( alcohol dehydrogenase II subunit )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDRPHENYLAC__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3O__45__4151" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__4" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mshD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: mycothiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__120" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFATE__45__ADENYLYLTRANSFERASE__45__ADP__45__RXN" name="Sulfate adenylyltransferase (ADP)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( apt ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylylsulfate:phosphate adenylyltransferase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sulfite oxidation II</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur oxidation (Acidianus ambivalens)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.5</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__0" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: mycothiol-mediated detoxification</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: BR__45__</html:p>
<html:p>SIDE: CPD1G__45__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__2" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__159" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__130" stoichiometry="1"/>
      <speciesReference species="BR__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mshB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MshB )</html:p>
<html:p>SUBSYSTEM: mycothiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__1" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__0" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( acnA ) or ( acnA ) or ( acn ) or ( HP0779 ) or ( acnB ) or ( acnB ) or ( ACO2 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitate hydratase 1 ) or ( NA ) or ( NA ) or ( aconitase ) or ( aconitate hydratase 2 ) or ( NA ) or ( aconitate hydratase, mitochondrial precursor ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle II</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle I</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYXK__45__RXN" name="L-xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lyxK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-xylulose kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-lyxose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.53</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__XYLULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R481__45__RXN" name="Glycine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AB094497 ) or ( AF216281 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis IV (from glycine)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.156</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHOSINEPHOSPHORY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( xapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucloside phosphorylase ) or ( XapA )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINE__45__DEHYDROGENASE__45__RXN" name="Spermidine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ATAO1 ) or (  ) or ( BPAO2 ) or ( MPAO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( copper amine oxidase ) or ( amine oxidase ) or ( polyamine oxidase ) or ( polyamine oxidase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.6</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__4110" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG27 ) or ( HSD17B7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-keto sterol reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4578" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__METHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ARABINOKINASE__45__RXN" name="L-arabinokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARA1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-L-arabinose biosynthesis II (from L-arabinose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.46</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1825" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOCATECHUATE__45__45__45__DIOXYGENASE__45__RXN" name="Protocatechuate 4,5-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PmdB and PmdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protocatechuate 4,5-dioxygenase &amp;beta; subunit and protocatechuate 4,5-dioxygenase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation I (meta-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__87" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLGLUTKIN__45__RXN" name="Acetylglutamate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( argB ) or ( ARG5,6 ) or ( argB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ArgB ) or ( NA ) or ( acetylglutamate kinase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__264__45__RXN" name="L-idonate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( idnD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>SUBSYSTEM: L-idonate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.264</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__IDONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__DEHYDROGLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__103__45__RXN" name="Phosphoethanolamine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LOC_Os01g50030.1 ) or ( AT1G73600 ) or ( PEAMT ) or ( NMT 1 ) or ( AT1G48600 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoethanolamine N-methyltransferase, putative, expressed ) or ( phosphoethanolamine N-methyltransferase ) or ( NA ) or ( NA ) or ( phosphoethanolamine N-methyltransferase ) or ( phosphoethanolamine N-methyltransferase ) or ( phosphoethanolamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.103</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__406" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSACET__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( LYC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.32</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__567" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__162__45__RXN" name="Taxadien-5-&amp;alpha;-ol O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: taxol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.162</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAXA__45__42011__45__DIEN__45__5A__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAXA__45__42011__45__DIEN__45__5__45__ALPHA__45__YL__45__ACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__74__45__RXN" name="Pyridoxal phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cof ) or ( ybhA ) or ( yigL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( sugar phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.74</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__139__45__RXN" name="1D-myo-inositol-trisphosphate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( at5g16760 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3)</html:p>
<html:p>SUBSYSTEM: superpathway of lipid-dependent phytate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.134</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5041" name="dipicolinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dpaA and dpaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dipicolinate synthase &amp;alpha; subunit and dipicolinate synthase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4841" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R5__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phloroglucinol reductase subunit )</html:p>
<html:p>SUBSYSTEM: gallate degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.57</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__16" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__17" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENDECARBOX__45__RXN" name="Uroporphyrinogen decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hemE ) or ( hemE ) or ( UROD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen decarboxylase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen II</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.37</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DSERDEAM__45__RXN" name="D-serine ammonia-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dsdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__16__45__RXN" name="(-)-(4S)-limonene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Car ) or ( TPS-Lim ) or ( g-&amp;beta;phe ) or ( f-&amp;gamma;hum ) or ( g-teo ) or ( f-&amp;delta;sel1 ) or ( g-cam ) or ( g-lim1 ) or (  ) or ( LC ) or ( g-pin2 ) or ( TPS-Pin ) or ( TPS-Cin ) or ( TPS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-carene synthase ) or ( limonene synthase ) or ( &amp;beta;-phellandrene synthase ) or ( &amp;gamma;-humulene synthase ) or ( terpinolene synthase ) or ( &amp;delta;-selinene synthase ) or ( camphene synthase ) or ( limonene synthase ) or ( NA ) or ( NA ) or ( limonene/&amp;alpha;-pinene synthase ) or ( pinene synthase ) or ( 1,8-cineole synthase ) or ( myrcene synthase )</html:p>
<html:p>SUBSYSTEM: oleoresin monoterpene volatiles biosynthesis</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>SUBSYSTEM: monoterpene biosynthesis</html:p>
<html:p>SUBSYSTEM: (4R)-carvone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.16</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4886" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIMSYN3__45__RXN" name="Phosphomethylpyrimidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( thiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.7</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYM__45__PHOSPH__45__RXN" name="Thymidine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( deoA ) or ( deoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( DeoA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="THYMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__32__45__RXN" name="Geranylgeranyl-diphosphate geranylgeranyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: trans-lycopene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.32</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__464" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ndk ) or ( NME2 and NME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ndk ) or ( nucleoside diphosphate kinase B and nucleoside diphosphate kinase A )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5985" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bio2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthase subunit )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5662" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP__45__MANNOSE_TO_GDP_COF_RXN" name="GDP-MANNOSE_TO_GDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5984" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bio2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthase subunit )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__5662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDATE__45__PHOSPHATASE__45__RXN" name="Phosphatidate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtLPP1 ) or ( AtLPP2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AtLPP1 ) or ( AtLPP2 )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPYRIMIDINASE__45__RXN" name="Dihydropyrimidinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCTP__45__PYROPHOSPHATASE__45__RXN" name="dCTP pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nudI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrimidine deoxynucleoside triphosphate pyrophosphohydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLATECYC__45__RXN" name="Adenylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cyaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTATE__45__DEHYDROGENASE__45__RXN" name="Dihydroorotate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pyrD ) or ( PYRD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PyrD ) or ( dihydroorotate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.5.2</html:p>
<html:p>SIDE: __124__Quinols__124__</html:p>
<html:p>SIDE: __124__Quinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Quinols__124__" stoichiometry="1"/>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALTRO__45__OXIDOREDUCT__45__RXN" name="Tagaturonate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( uxaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hexuronide and hexuronate degradation</html:p>
<html:p>SUBSYSTEM: D-galacturonate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.58</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__TAGATURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALTRONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5064" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP79D2 ) or ( CYP79D3 ) or ( CYP79D4 ) or ( CYP79D1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( valine N-monooxygenase )</html:p>
<html:p>SUBSYSTEM: superpathway of linamarin and lotaustralin biosynthesis</html:p>
<html:p>SUBSYSTEM: linamarin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4862" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4863" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIB5PISOM__45__RXN" name="Ribose 5-phosphate epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rpiA ) or ( rpiB ) or ( rpiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( allose-6-phosphate isomerase / ribose-5-phosphate isomerase B monomer ) or ( ribose-5-phosphate isomerase A )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5063" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP79D2 ) or ( CYP79D3 ) or ( CYP79D4 ) or ( CYP79D1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( valine N-monooxygenase )</html:p>
<html:p>SUBSYSTEM: superpathway of linamarin and lotaustralin biosynthesis</html:p>
<html:p>SUBSYSTEM: linamarin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4862" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCDEHYDROG__45__RXN" name="Glucose dehydrogenase (pyrroloquinoline-quinone)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( yliI ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldose sugar dehydrogenase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.5.2</html:p>
<html:p>COFACTOR: __124__Ubiquinols__124__</html:p>
<html:p>COFACTOR: __124__Ubiquinones__124__</html:p>
<html:p>SIDE: __124__Ubiquinols__124__</html:p>
<html:p>SIDE: __124__Ubiquinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8404" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chrysophanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8215" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8216" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__4__46__1__45__RXN" name="(Hydroxyamino)benzene mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( habA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: nitrobenzene degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.4.4.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYAMINOBENZENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8406" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8214" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8225" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8405" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CPD__45__8212</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>SIDE: OH</html:p>
<html:p>SIDE: CPD__45__8208</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH" stoichiometry="1"/>
      <speciesReference species="CPD__45__8208" stoichiometry="1"/>
      <speciesReference species="CPD__45__842" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8212" stoichiometry="1"/>
      <speciesReference species="CPD__45__8211" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acsD and acsC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( corrinoid/iron-sulfur protein &amp;alpha; subunit and corrinoid/iron-sulfur protein &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: __124__Cofactors__124__</html:p>
<html:p>SIDE: __124__Reduced__45__cofactors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Reduced__45__cofactors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__842" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8214" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
      <speciesReference species="__124__Cofactors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1PFRUCTPHOSN__45__RXN" name="1-phosphofructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fruK ) or ( fruC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-phosphofructokinase monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: fructose degradation</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.56</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__39__45__RXN" name="4-hydroxybenzoate nonaprenyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiA ) or ( AtPPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.39</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="SOLANESYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NONAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8408" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8225" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="2"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-6 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HEXAPRENYL__45__3__45__METHYL__45__5__45__HYDROXY__45__6__45__METHOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__30" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8407" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8225" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="2"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8409" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PCME )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__FARNESYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__ETC__45__CYSTEINE" stoichiometry="1"/>
      <speciesReference species="METOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAADEHYDROG__45__RXN" name="D-amino-acid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dadA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-amino acid dehydrogenase, small subunit and D-amino acid dehydrogenase, large subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYBENZALDEHYDE__45__OXIDATION__45__NAD__45__RXN" name="4-hydroxybenzaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: toluene degradation to protocatechuate (via p-cresol)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation III (aerobic) (via p-cresol)</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.64</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXYBENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LEUCPEL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AT4g22880 ) or ( AT4g22870 ) or ( At2g38240 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( anthocyanidin synthase ) or ( anthocyanidin synthase ) or ( anthocyanidin synthase )</html:p>
<html:p>SUBSYSTEM: anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEUCOPELARGONIDIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PELARGONIDIN__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TSDOSALCAL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( orthanilate dioxygenase system, oxygenase component and orthanilate dioxygenase system, reductase component ) or ( benzenesulfonate dioxygenase system, reductase component and benzenesulfonate dioxygenase system, oxygenase component )</html:p>
<html:p>SUBSYSTEM: 4-toluenesulfonate degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__TOLUENESULFONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__METHYLCATECHOL" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITRULLINASE__45__RXN" name="Citrullinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II (from arginine)</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.20</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R103__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ectC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ectoine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__L__45__24__45__DIAMINOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ECTOINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLISOCITRATE__45__LYASE__45__RXN" name="Methylisocitrate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( prpB ) or ( prpB ) or ( prpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 2-methylisocitrate lyase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle I</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle II</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.30</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__618" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIGLUCOACETYL__45__DOCOSANOATE__45__ACETYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sophorosyloxydocosanoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIGLUCOACETYL__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIGLUCODIACETYL__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__269__45__RXN" name="2-(S)-hydroxypropyl-CoM dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xecE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-(S)-hydroxypropyl-CoM dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: propylene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.269</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__S__45__HYDROXYPROPYL__45__COM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOPROPYL__45__COM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__20__45__RXN" name="Desacetoxyvindoline 4-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( D4H )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vindoline and vinblastine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.20</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEACETOXYVINDOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_17__45__O__45__DEACETYLVINDOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYRAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tyrB ) or ( ARO8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TyrB ) or ( aromatic amino acid aminotransferase I )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine degradation III</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHORIBULOKINASE__45__RXN" name="Phosphoribulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PRK and CP12-2 and GapA-1 ) or ( PRK ) or ( prk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CP12 subunit and glyceraldehyde 3-phosphate dehydrogenase subunit and phosphoribulokinase subunit ) or ( phosphoribulokinase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.19</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__RIBULOSE__45__15__45__P2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_23__45__DIMETHYLMALATE__45__LYASE__45__RXN" name="2,3-dimethylmalate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dml )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-dimethylmalate lyase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.32</html:p>
<html:p>SIDE: PROPIONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__61" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DMK__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( menA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXYNAPHTHOATE" stoichiometry="1"/>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEMETHYLMENAQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6782" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6783" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6781" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6782" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6783" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6746" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7302" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6781" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6745" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7301" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__PENTAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6781" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROXYISOVALDEHYDRAT__45__RXN" name="Dihydroxy-acid dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ilvD ) or ( ilvD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihidroxy acid dehydratase subunit ) or ( IlvD )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIOH__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R214__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__285" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__291" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R83__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( masA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXY__45__3__45__KETO__45__5__45__METHYLTHIO__45__1__45__PHOSPHOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDREDUCT__45__RXN" name="Lactaldehyde reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fucO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-1,2-propanediol oxidoreductase monomer )</html:p>
<html:p>SUBSYSTEM: L-lactaldehyde degradation (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of fucose and rhamnose degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.77</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPANE__45__1__45__2__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PUTTRANSAM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ygjG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: putrescine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.82</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYANIDE__45__HYDRATASE__45__RXN" name="Cyanide hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ygiU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.66</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__95__45__RXN" name="7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP8B1 and POR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADPH-cytochrome P450 reductase and cytochrome P450 8B1 )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.95</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1087" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7237" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__L__45__RHAMNOSE_TO_UDP_COF_RXN" name="UDP-L-RHAMNOSE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__L__45__RHAMNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNA__45__RXN" name="Aspartate--ammonia ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( asnB ) or ( asnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AsnB ) or ( AsnA )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine.</html:p>
<html:p>SUBSYSTEM: superpathway of asparagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LUT5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lutein biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__118" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5661" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__54__45__RXN" name="&amp;gamma;-guanidinobutyraldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PP5278 ) or (  ) or ( kauB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( aminobutyraldehyde dehydrogenase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: arginine degradation VIII (arginine oxidase pathway)</html:p>
<html:p>SUBSYSTEM: arginine degradation IX (arginine:pyruvate transaminase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.54</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__825" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__592" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LUT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lutein biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5661" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__119" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__CH3__45__2__45__OXOBUTANOATE__45__OH__45__CH3__45__XFER__45__RXN" name="3-methyl-2-oxobutanoate hydroxymethyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( panB ) or ( PANB2 ) or ( PANB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methyl-2-oxobutanoate hydroxymethyltransferase monomer ) or ( ketopantoate hydroxymethyltransferase ) or ( ketopantoate hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.11</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: METHYLENE__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE__45__CARBOXYLASE__45__RXN" name="Pyruvate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pyc ) or ( pyc ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( pyruvate carboxylase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: incomplete reductive TCA cycle</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__N__45__MONOOXYGENASE__45__RXN" name="Tyrosine N-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cyp79A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dhurrin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__267" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8469" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ZCO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: crocetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__130" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8660" stoichiometry="1"/>
      <speciesReference species="CPD__45__8661" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__LACTAMASE__45__RXN" name="&amp;beta;-lactamase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ampC ) or ( dacA ) or ( blaB ) or ( blaP1a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-lactamase; penicillin resistance ) or ( D-alanyl-D-alanine carboxypeptidase, fraction A; penicillin-binding protein 5 ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__Lactams__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8550" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__NOPALINE__45__DEHYDROGENASE__45__RXN" name="D-nopaline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( noxB and noxA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nopaline oxidase subunit A and nopaline oxidase subunit B )</html:p>
<html:p>SUBSYSTEM: nopaline degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.19</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__308" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__AMINOPENTANAMIDASE__45__RXN" name="5-aminopentanamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( davA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation IV</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.30</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINOPENTANAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINOPENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPACYLGLCNACDEACETYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lpxC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__OHMYR__45__ACETYLGLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="UDP__45__OHMYR__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8475" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( crocetin glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: crocetin esters biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8664" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8665" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8473" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( GLT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( crocetin glucosyltransferase subunit ) or ( crocetin glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: crocetin esters biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8663" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8667" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8471" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( GLT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( crocetin glucosyltransferase subunit ) or ( crocetin glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: crocetin esters biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8662" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8663" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__25__45__RXN" name="2-oxoisovalerate dehydrogenase (acylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BCKDHB and DBT and DLD and BCKDHA ) or ( bfmBAA and bfmBAB and pdhD and bfmBB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrolipoyl dehydrogenase subunit and branched-chain &amp;alpha;-keto acid dehydrogenase complex E2 component subunit and branched-chain &amp;alpha;-keto acid dehydrogenase E1 component &amp;alpha; subunit and branched-chain &amp;alpha;-keto acid dehydrogenase E1 component &amp;beta; subunit ) or ( 2-keto-isovalerate dehydrogenase component &amp;alpha; subunit and lipoamide acyltransferase component subunit and dihydrolipoyl dehydrogenase component subunit and 2-keto-isovalerate dehydrogenase component &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.25</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8459" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: raspberry ketone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8636" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8647" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8455" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 4&apos;CGT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: aurone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3021" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8633" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9589" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( XGD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylogalacturonan xylosyltransferase )</html:p>
<html:p>SUBSYSTEM: xylogalacturonan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__D__45__XYLOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__galacturonosyl__124__" stoichiometry="1"/>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="CPD__45__10235" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOFLAVONE__45__2__45__HYDROXYLASE__45__RXN" name="Isoflavone 2&apos;-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP81E3 ) or ( CYP81E7 ) or ( CYP81E1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: medicarpin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.53</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMONONETIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXYFORMONONETIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8454" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AmAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aureusidin synthase )</html:p>
<html:p>SUBSYSTEM: aurone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.21.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8632" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8634" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Malate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdh6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP malate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: C4 photosynthetic carbon assimilation cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.82</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9587" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rifK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-amino-5-hydroxybenzoate synthase subunit )</html:p>
<html:p>SUBSYSTEM: 3-amino-5-hydroxybenzoate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of rifamycin B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10230" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10231" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8457" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cfiA and cfiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-oxoglutarate carboxylase large subunit and 2-oxoglutarate carboxylase small subunit )</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle II</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.7</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9588" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dhurrinase 2 ) or ( Dhr1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: dhurrin degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1042" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__648" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8456" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AmAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aureusidin synthase )</html:p>
<html:p>SUBSYSTEM: aurone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.21.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8633" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8635" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SIROHEME__45__FERROCHELAT__45__RXN" name="Sirohydrochlorin ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cysG ) or ( cysG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CysG ) or ( uroporphyrinogen-III C-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCHORMAT__45__RXN" name="Isochorismatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( entB ) or ( dhbB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( EntB ) or ( DhbB monomer )</html:p>
<html:p>SUBSYSTEM: 2,3-dihydroxybenzoate biosynthesis</html:p>
<html:p>SUBSYSTEM: bacillibactin biosynthesis</html:p>
<html:p>SUBSYSTEM: enterobactin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOCHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRO__45__DIOH__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEHYDR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( acnA ) or ( acn ) or ( HP0779 ) or ( acnB ) or ( ACO2 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( aconitase ) or ( NA ) or ( aconitate hydratase, mitochondrial precursor ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle II</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle I</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__29__45__RXN" name="Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cis-1,2-dihydro-1,2-dihydroxynaphthalene-1, 2-dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.29</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__12__45__DIHYDRONAPHTHALENE__45__12__45__DIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAPHTHALENE__45__12__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__18__45__RXN" name="Abietadiene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gg-agi ) or ( TPS-LAS ) or ( TPS-LAS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abietadiene synthase ) or ( levopimaradiene/abietadiene synthase ) or ( levopimaradiene/abietadiene synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: dehydroabietic acid biosynthesis</html:p>
<html:p>SUBSYSTEM: abietic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4750" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__45____45__ABIETADIENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betalain biosynthesis (to betalamic acid)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRANOSE__45__OXIDASE__45__RXN" name="Pyranose oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( p2ox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyranose oxidase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__327" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9592" name="Sulfoacetaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( safD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfoacetaldehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: sulfoacetaldehyde degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.73</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SULFOACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10246" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPPSYN__45__RXN" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPPS ) or ( GGPPS ) or ( hbgg ) or ( ispA ) or ( GPPS-lsu and GPPS-ssu ) or ( NA ) or ( FPP1 ) or ( FDPS ) or ( FPS1 ) or ( GGPS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( prenyltransferase subunit ) or ( NA ) or ( NA ) or ( geranyl pyrophosphate synthase, large subunit and geranyl pyrophosphate synthase, small subunit ) or ( farnesyl pyrophosphate synthetase FPP synthetase FPS farnesyl diphosphate synthetase ) or ( Erg20 ) or ( farnesyl pyrophosphate synthetase ) or ( NA ) or ( geranylgeranyl pyrophosphate synthetase )</html:p>
<html:p>SUBSYSTEM: geranyldiphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9591" name="Glycerol-3-phosphate O-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( plsY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acyl__45__Phosphates__124__" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8460" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DODA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betalain biosynthesis (to betalamic acid)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNKIN__45__RXN" name="D-mannose transport" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( Hxk2 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( hexokinase ) or ( hexokinase ) or ( mannokinase )</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: mannitol degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.7</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__5__45__MONOOXYGENASE__45__RXN" name="Tryptophan 5-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 5-hydroxylase subunit )</html:p>
<html:p>SUBSYSTEM: serotonin and melatonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.4</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__5881</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
      <speciesReference species="_5__45__HYDROXY__45__TRYPTOPHAN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8489" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit 1 tyrosinase and subunit 2 tyrosinase )</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopaxanthin)</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8671" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8672" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8488" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit 1 tyrosinase and subunit 2 tyrosinase )</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopaxanthin)</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.-</html:p>
<html:p>SIDE: L__45__DEHYDRO__45__ASCORBATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ASCORBATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8670" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8671" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINSYN__45__RXN" name="argininosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG1 ) or ( argG ) or ( argG ) or ( ASS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginosuccinate synthetase ) or ( ArgG ) or ( ArgG ) or ( argininosuccinate synthase subunit )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8487" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopaxanthin)</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8670" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__301" name="N-methyl-L-amino-acid oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( solA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__METHYLTRYPTOPHAN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__300" name="Glyoxylate reductase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ghrB ) or ( ghrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GhrB ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHANE__45__MONOOXYGENASE__45__RXN" name="Methane monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mmoX and mmoY and mmoZ and mmoC and orfY and mmoB ) or ( orfY and mmoC and mmoB and mmoZ and mmoY and mmoX ) or ( pmoA1 and pmoA2 and pmoB1 and pmoB2 and pmoC1 and pmoC2 and pmoC3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( soluble methane monooxygenase regulatory component and soluble methane monooxygenase MMOD component and soluble methane monooxygenase hydroxylase component &amp;gamma; subunit and soluble methane monooxygenase reductase component and soluble methane monooxygenase hydroxylase component &amp;alpha; subunit and soluble methane monooxygenase hydroxylase component &amp;beta; subunit ) or ( soluble methane monooxygenase hydroxylase component &amp;gamma; subunit and soluble methane monooxygenase hydroxylase component &amp;alpha; subunit and soluble methane monooxygenase hydroxylase component &amp;beta; subunit and soluble methane monooxygenase MMOD component and soluble methane monooxygenase regulatory component and soluble methane monooxygenase reductase component ) or ( particulate methane monooxygenase hydroxylase component &amp;alpha; subunit and particulate methane monooxygenase hydroxylase component &amp;beta; subunit and particulate methane monooxygenase hydroxylase component &amp;gamma; subunit )</html:p>
<html:p>SUBSYSTEM: methane oxidation to methanol</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.25</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CH4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__131__45__RXN" name="Precorrin-3B C17-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.131</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__643" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__651" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__91__45__RXN" name="Deoxysarpagine hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.91</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_10__45__DEOXYSARPAGINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4243" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__156__45__RXN" name="Adenosylcobinamide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cobP ) or ( cobU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CobP ) or ( adenosylcobinamide-phosphate guanylyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.156</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Triphosphates__124__" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Diphosphates__124__" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( iscS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine desulfurase monomer )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.7</html:p>
<html:p>SIDE: PROT__45__CYS</html:p>
<html:p>SIDE: ENZYME__45__S__45__SULFANYLCYSTEINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ENZYME__45__S__45__SULFANYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATASE__45__RXN" name="Glucose-6-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( G6PC ) or ( yfbT ) or ( ybiV ) or ( yigL ) or ( yidA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( sugar phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( alsE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: D-allose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALLULOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__305" name="Hydroxypyruvate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hyi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__302" name="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IspF ) or ( ispF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.12</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PHOSPHO__45__4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C__45__MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rpiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allose-6-phosphate isomerase / ribose-5-phosphate isomerase B monomer )</html:p>
<html:p>SUBSYSTEM: D-allose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALLOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALLULOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8492" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: amaranthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: CPD__45__8674</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8674" stoichiometry="1"/>
      <speciesReference species="CPD__45__8658" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8675" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__36__45__RXN" name="5-O-(4-coumaroyl)-D-quinate 3&apos;-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP98A35 ) or ( C3H1 ) or ( REF8 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( p-coumaroyl ester 3&apos;-hydroxylase ) or ( NA ) or ( p-coumaroyl shikimate/quinate 3&apos;-hydroxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__COUMAROYLQUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAFFEOYLQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8493" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: amaranthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: CPD__45__8673</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8673" stoichiometry="1"/>
      <speciesReference species="CPD__45__8658" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8676" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8490" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopaxanthin)</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8672" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8653" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8491" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopaxanthin)</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8671" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8496" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( StDES )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: divinyl ether biosynthesis I (9-LOX)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8677" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8679" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8497" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LOX1 ) or ( lox1:St:2 ) or ( r9-LOX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 9-LOX and 9-AOS pathway</html:p>
<html:p>SUBSYSTEM: divinyl ether biosynthesis I (9-LOX)</html:p>
<html:p>SUBSYSTEM: 9-LOX and 9-HPL pathway</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.-</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLENIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8678" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__99__46__33__45__RXN" name="&amp;delta;(12)-fatty acid dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Crep1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: crepenynic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.33</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CREPENYNATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R342__45__RXN" name="Cobaltochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobN and cobT and cobS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CobT and CobS and CobN )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 6.6.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CO__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__43__2" stoichiometry="1"/>
      <speciesReference species="CPD__45__688" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__689" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8495" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LOX1 ) or ( lox1:St:2 ) or ( r9-LOX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 9-LOX and 9-AOS pathway</html:p>
<html:p>SUBSYSTEM: divinyl ether biosynthesis I (9-LOX)</html:p>
<html:p>SUBSYSTEM: 9-LOX and 9-HPL pathway</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.-</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8677" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8479" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 5-GT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betacyanin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8653" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8654" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8478" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betacyanin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
      <speciesReference species="CPD__45__8652" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8653" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__310" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( scpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ScpB )</html:p>
<html:p>SUBSYSTEM: conversion of succinate to propionate</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.41</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PUTRESCINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Putrescine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( PMT ) or ( PMT ) or ( PMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: N-methyl-&amp;Delta;1-pyrrolinium cation biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.53</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__394" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R310__45__RXN" name="Nitrile hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nthB and nthA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrile hydratase &amp;alpha; subunit and nitrile hydratase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: acrylonitrile degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLONITRILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__313" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fsaA ) or ( fsaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Fsa ) or ( fructose 6-phosphate aldolase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__C__45__RXN" name="Phospholipase C" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NPC4 ) or ( NPC5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PHOSPHORYL__45__CHOLINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8480" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 6-GT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betacyanin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8653" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8655" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8481" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cDOPA5GT ) or ( cDOPA5GT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betacyanin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8652" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8656" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8482" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betacyanin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8656" stoichiometry="1"/>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8654" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8483" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betacyanin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8652" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8484" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: amaranthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8656" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8657" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8485" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: amaranthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
      <speciesReference species="CPD__45__8657" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8658" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8486" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopamine)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8659" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLU6PDEHYDROG__45__RXN" name="Glucose-6-phosphate 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( zwf ) or ( zwf ) or ( zwf )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate dehydrogenase subunit ) or ( glucose-6-phosphate 1-dehydrogenase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.49</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8429" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 ) or ( f-&amp;gamma;hum ) or ( f-&amp;delta;sel1 ) or ( TPS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;gamma;-humulene synthase ) or ( &amp;delta;-selinene synthase ) or ( sesquiterpene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8246" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8427" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8243" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8244" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRUNASIN__45__BETA__45__GLUCOSIDASE__45__RXN" name="Prunasin &amp;beta;-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: amygdalin and prunasin degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.118</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__553" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="MANDELONITRILE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8428" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8245" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8425" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 ) or ( TPS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( sesquiterpene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8242" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZENE__45__12__45__DIOXYGENASE__45__RXN" name="Benzene 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bedA and bedC2 and bedC1 and bedB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzene 1,2 dioxygenase terminal oxygenase component &amp;alpha; subunit and benzene 1,2 dioxygenase terminal oxygenase component &amp;beta; subunit and benzene 1,2-dioxygenase ferredoxin reductase subunit and benzene 1,2 dioxygenase ferredoxin subunit )</html:p>
<html:p>SUBSYSTEM: benzene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__288" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8426" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8243" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8423" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8240" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8424" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8241" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8421" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8238" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8422" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 ) or ( eafar ) or ( TPS-Lon ) or ( CJFS ) or ( &amp;beta;-FS ) or ( f-&amp;gamma;hum ) or ( TPS1 ) or ( TPS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( &amp;gamma;-humulene synthase ) or ( NA ) or ( sesquiterpene synthase )</html:p>
<html:p>SUBSYSTEM: farnesene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8239" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8431" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8248" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8430" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 ) or ( TPS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( sesquiterpene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8247" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FGAMSYN__45__RXN" name="phosphoribosylformylglycinamidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade6 ) or ( purL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__FORMYLGLUTAMATE__45__DEFORMYLASE__45__RXN" name="N-formylglutamate deformylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hutG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.68</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__600" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="POLYPHOSPHATE__45__KINASE__45__RXN" name="Polyphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ppk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ppk )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8418" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8236" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8419" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8237" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALLATE__45__DECARBOXYLASE__45__RXN" name="Gallate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gallate degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.59</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__183" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYROGALLOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTP_TO_CDP_COF_RXN" name="CTP_TO_CDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8414" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G23960 ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>SUBSYSTEM: oleoresin sesquiterpene volatiles biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8230" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8415" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G23960 ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8233" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8416" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G23960 ) or ( f-&amp;gamma;hum ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;gamma;-humulene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8234" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8417" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G44630 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8235" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8410" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mcrB and mcrA and mcrG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta; subunit and &amp;alpha; subunit and &amp;gamma; subunit )</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__845" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="CH4" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8411" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FADX-1 ) or ( FADX-2 ) or ( Fac2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: calendate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8228" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8412" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PuFADX ) or ( PgFac ) or ( TkFac )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: punicic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8229" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8413" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MomoFADX ) or ( AfFADX ) or ( ImpFADX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;alpha;-eleostearic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8231" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3OHSTEROXRED__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&amp;alpha;-hydroxysteroid oxidoreductase )</html:p>
<html:p>SUBSYSTEM: cholate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OXO__45__DEOXYCHOLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYCHOLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_SUC_COF_RXN" name="2-KETOGLUTARATE_TO_SUC_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRE6PHYDRO__45__RXN" name="&amp;alpha;,&amp;alpha;-phosphotrehalase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( treA ) or ( treC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trehalose degradation I (low osmolarity)</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.93</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__36__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (GDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( otsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose phosphate synthase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.36</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__40__45__RXN" name="3-&amp;alpha;,7-&amp;alpha;,12-&amp;alpha;-trihydroxycholestan-26-al 26-oxidoreductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdxr and Cyp27a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 27A1 and NA )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.40</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__ALPHA7__45__ALPHA12__45__ALPHA__45__TRIHYDROX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1836" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOPHOSPHAT__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1086" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nrdE and nrdF ) or ( nrdB and nrdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NrdE and NrdF ) or ( NrdA and NrdB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.4.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxy__45__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2761" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: plastoquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
      <speciesReference species="SOLANESYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__6__45__SOLANYL__45__14__45__BENZOQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2762" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTE3 ) or ( sll0418 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: plastoquinone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__METHYL__45__6__45__SOLANYL__45__14__45__BENZOQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PLASTOQUINONE__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOCATECHUATE__45__34__45__DIOXYGENASE__45__RXN" name="Protocatechuate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcaG and pcaH ) or ( pcaH2 and pcaG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protocatechuate 3,4-dioxygenase &amp;beta; subunit and protocatechuate 3,4-dioxygenase &amp;alpha; subunit ) or ( protocatechuate 3,4-dioxygenase type II &amp;alpha; subunit and protocatechuate 3,4-dioxygenase type II &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: aromatic compounds degradation via &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation III (aerobic) (via p-cresol)</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__245" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMATE__45__FORMIMINOTRANSFERASE__45__RXN" name="Glutamate formiminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FTCD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formimidoyltransferase-cyclodeaminase subunit )</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.5</html:p>
<html:p>SIDE: THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__FORMIMINO__45__L__45__GLUTAMATE" stoichiometry="1"/>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__671" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8444" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling (plants)</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE__45__5P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8449" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.159</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__437" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RUTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8447" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__OXO__45__4__45__PHOSPHONOOXYBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__AMINO__45__PROPAN__45__2__45__ONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_12__45__OXOPHYTODIENOATE__45__REDUCTASE__45__RXN" name="12-oxophytodienoate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At1g76690 ) or ( At1g76680 ) or ( At1g09400 ) or ( At1g17990 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 12-oxophytodienoate reductase ) or ( 12-oxophytodienoate reductase ) or ( 12-oxophytodienoate reductase ) or ( 12-oxophytodienoate reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: jasmonic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__729" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__730" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__METHYLTHIOADENOSINE__45__PHOSPHORYLASE__45__RXN" name="5&apos;-methylthioadenosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MTAP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MTAP subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8453" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 4&apos;CGT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: aurone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APIGENIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8632" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8452" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CrOMT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: syringetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.149</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8605" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SYRINGETIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__2__46__10__45__RXN" name="UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( murF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__209" stoichiometry="1"/>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALSYN__45__RXN" name="malate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( glcB ) or ( glcB ) or ( aceB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate synthase ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycol metabolism and degradation</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.9</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8451" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CrOMT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: syringetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.149</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYRICETIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8605" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__217__45__RXN" name="Mannosyl-3-phosphoglycerate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mngA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.217</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: G3P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__MANNOSYL__45__3__45__PHOSPHOGLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINE__45__KINASE__45__RXN" name="Ethanolamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TC96379 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ethanolamine kinase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylethanolamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.82</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLCNACPTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLCNAC__45__PP__45__LIPID" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavone 7-O-&amp;beta;-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: apigenin glycosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.81</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__431" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APIGENIN__45__7__45__O__45__BETA__45__D__45__GLUCOSIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENPRODIOLDEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hcaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBOXYETHYL__45__3__45__5__45__CYCLOHEXADIENE__45__1__45__2__45__DIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__DIHYDROXYPHENYL__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__51__45__RXN" name="&amp;beta;-pyrazolylalanine synthase (acetylserine)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-pyrazole-1-ylalanine synthase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-pyrazole-1-ylalanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.51</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: ACETYLSERINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRAZOLE" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__670" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( C12RT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,2 rhamnosyltransferase )</html:p>
<html:p>SUBSYSTEM: naringenin glycoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.236</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__7__45__O__45__BETA__45__D__45__GLUCOSIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NARINGIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8432" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G23960 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8232" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R311__45__RXN" name="Amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( amiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha; subunit of amidase ) or ( amidase subunit )</html:p>
<html:p>SUBSYSTEM: acrylonitrile degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8433" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MELIBIOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8249" stoichiometry="1"/>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8434" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( KcMS ) or ( LUP2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: mangrove triterpenoid biosynthesis</html:p>
<html:p>SUBSYSTEM: &amp;alpha;-amyrin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8250" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8435" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GolS-2 ) or ( GolS ) or ( GolS-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: B series fagopyritols biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8052" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8253" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBREDUCT__45__RXN" name="Pyrroline-5-carboxylate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( proC ) or (  ) or ( PRO3 ) or ( proC ) or (  ) or ( PYCR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ProC ) or ( NA ) or ( pyrroline-5-carboxylate reductase subunit ) or ( pyrroline-5-carboxylate reductase monomer ) or ( pyrroline-5-carboxylate reductase ) or ( pyrroline-5-carboxylate reductase 1 subunit )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II (from arginine)</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPCARBTRANS__45__RXN" name="Aspartate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pyrBI ) or ( CAD ) or ( pyrB and pyrI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PyrBI ) or ( CAD protein ) or ( aspartate carbamoyltransferase, PyrI subunit and aspartate carbamoyltransferase, PyrB subunit )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8438" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GolS-2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: A series fagopyritols biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8052" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8257" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOBENZCOALIG__45__RXN" name="Anthranilate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( bzda ) or ( abmG2 ) or ( bcla ) or ( abmG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anaerobic aminobenzoate-CoA ligase ) or ( benzoate-CoA ligase subunit ) or ( aerobic 2-aminobenzoate-CoA ligase type 2 ) or ( benzoate-CoA ligase ) or ( aerobic 2-aminobenzoate-CoA ligase type I )</html:p>
<html:p>SUBSYSTEM: anthranilate degradation II (aerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: anthranilate degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.32</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOBENZOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SINAPINE__45__ESTERASE__45__RXN" name="Sinapine esterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sinapate ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.49</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CHOLINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__SINAPOYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="SINAPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R322__45__RXN" name="precorrin-6A synthase (deacetylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.152</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__662" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__675" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DXS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CLA1 ) or ( dxs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( Dxs )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.7</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__77__45__RXN" name="4-oxalocrotonate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nbaG ) or ( xylI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 4-oxalocrotonate decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: nitrobenzene degradation I</html:p>
<html:p>SUBSYSTEM: catechol degradation II (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: 2-amino-3-carboxymuconate semialdehyde degradation to 2-oxopentenoate</html:p>
<html:p>SUBSYSTEM: catechol degradation to 2-oxopent-4-enoate II</html:p>
<html:p>SUBSYSTEM: orthanilate degradation</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation I</html:p>
<html:p>SUBSYSTEM: meta cleavage pathway of aromatic compounds</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.77</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__246" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXOPENTENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__49__45__RXN" name="Dihydroxyphenylalanine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis II</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.49</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_34__45__DIHYDROXYPHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R170__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ndh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH:ubiquinone oxidoreductase II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.16.1.-</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CU__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CU__43__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZALDEHYDE__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Benzaldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( xylC ) or ( ntnC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( subunit of benzaldehyde dehydrogenase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation IV (aerobic) (via catechol)</html:p>
<html:p>SUBSYSTEM: mandelate degradation I</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoate</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.28</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FESO3OXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfite:ferric ion oxidoreductase &amp;beta; subunit and sulfite:ferric ion oxidoreductase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfide oxidation (Acidithiobacillus ferrooxidans)</html:p>
<html:p>SUBSYSTEM: sulfur oxidation II (Fe+3-dependent)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: FE__43__3</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="FE__43__3" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__45__45__RXN" name="Homospermidine synthase (spermidine-specific)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HSS1 ) or ( HSS ) or ( DHS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: homospermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.45</html:p>
<html:p>SIDE: CPD__45__313</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1821" stoichiometry="1"/>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADCLY__45__RXN" name="Aminodeoxychorismate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AY547289 ) or ( AY099783 ) or ( pabC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADCL subunits ) or ( NA ) or ( pabC )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.38</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ITP_TO_IDP_COF_RXN" name="ITP_TO_IDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ITP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__33__45__RXN" name="Amylo-1,6-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GDB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen debranching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Truncated__45__Limit__45__Dextrins__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__60__45__RXN" name="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ispD ) or ( MCT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-diphosphocytidyl-2C-methyl-D-erythritol synthetase monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.60</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__CYTIDINE__45__5__45__DIPHOSPHO__45__2__45__C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHA__45__AMYL__45__RXN" name="&amp;alpha;-amylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( amyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOPENTAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__56__45__RXN" name="Dihydrosanguinarine 10-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.56</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSANGUINARINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__HYDROXYDIHYDROSANGUINARINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPCARBOXYKIN__45__RXN" name="Phosphoenolpyruvate carboxykinase (ATP)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pck )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.49</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINEPNACETYLTRANS__45__RXN" name="Glucosamine-phosphate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GNA ) or ( GNA1 ) or ( Gnpnat1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( glucosamine-6-phosphate N-acetyltransferase subunit ) or ( glucosamine-6-phosphate N-acetyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.4</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9500" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dmtA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-methyltransferase I )</html:p>
<html:p>SUBSYSTEM: aflatoxins B2 and G2 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.109</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4586" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4587" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( omtA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-methyltransferase II )</html:p>
<html:p>SUBSYSTEM: aflatoxins B2 and G2 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.110</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4587" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4588" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9502" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ordA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: aflatoxins B2 and G2 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: METOH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4588" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__10177" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMARYLACETOACETASE__45__RXN" name="Fumarylacetoacetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAH ) or ( fahA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarylacetoacetate hydrolase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9508" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ntaB and ntaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrilotriacetate monooxygenase A subunit and nitrilotriacetate monooxygenase B subunit )</html:p>
<html:p>SUBSYSTEM: nitrilotriacetate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: FMN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FMNH2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10188" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
      <speciesReference species="CPD__45__10189" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__8__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPD1 ) or ( gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytoplasmic glycerol-3-phosphate dehydrogenase subunit ) or ( GpsA )</html:p>
<html:p>SUBSYSTEM: glycerol-3-phosphate shuttle</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SFS1 ) or ( THFS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 10-formyl-THF synthetase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AF030516 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYC subunits )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5727" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYDOCOSANOATE__45__TRANS__45__RXN" name="13-hydroxydocosanoate 13-&amp;beta;-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sophorosyloxydocosanoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.158</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__802" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__803" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__HYDROXYMELLEIN__45__O__45__METHYLTRANSFERASE__45__RXN" name="6-hydroxymellein O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 6-methoxymellein biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.108</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__HYDROXYMELLEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__METHOXYMELLEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNN__45__386" name="2-hydroxychromene-2-carboxylate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPDN__45__384" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPDN__45__385" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENINE__45__DEAMINASE__45__RXN" name="adenine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ade )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cryptic adenine deaminase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MEPROPCOA__45__FAD__45__RXN" name="2-methylacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acdH ) or ( Acadsb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase subunit ) or ( 2-methyl branched chain acyl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.12</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOPIPERITENOL__45__DEHYDROGENASE__45__RXN" name="Isopiperitenol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ISPD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.223</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__263" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1090" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__382" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( xylB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylulokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1093" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__385" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mutT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__384" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nudB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroneopterin triphosphate pyrophosphohydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMIMINOGLUTAMASE__45__RXN" name="Formiminoglutamase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hutG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formiminoglutamate formiminohydrolase subunit )</html:p>
<html:p>SUBSYSTEM: histidine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: FORMAMIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__FORMIMINO__45__L__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="FORMAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARACHIDONATE__45____45__COA__45__LIGASE__45__RXN" name="Arachidonate--CoA ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACSL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( long-chain-fatty-acid--CoA ligase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.15</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARACHIDONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORCINOL__45__2__45__MONOOXYGENASE__45__RXN" name="Orcinol 2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: orcinol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.6</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ORCINOL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__616" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDO__45__8PPHOSPHAT__45__RXN" name="3-deoxy-manno-octulosonate-8-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kdsC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.45</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="KDO__45__8P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Formaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fdhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formaldehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation IV (thiol-independent)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.46</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__1__46__9__45__RXN" name="trypanothione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TryS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: trypanothione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONYLSPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRYPANOTHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__KINASE__45__RXN" name="shikimate-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aroK ) or ( aroI ) or ( aroL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( shikimate kinase I ) or ( NA ) or ( shikimate kinase II )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.71</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLDIAMINOPIMELATE__45__DEACETYLASE__45__RXN" name="N-acetyldiaminopimelate deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ykuR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.47</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1771" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTONOLACTONASE__45__RXN" name="1,4-lactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: galactose degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.25</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GALACTONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__DEHYDRO__45__2__45__DEOXYGLUCONOKINASE__45__RXN" name="5-dehydro-2-deoxygluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-dehydro-2-deoxygluconokinase )</html:p>
<html:p>SUBSYSTEM: myo-inositol degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.92</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__827" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__645" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9563" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FaQR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: furaneol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10205" stoichiometry="1"/>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10198" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9564" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FaQR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: furaneol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="CPD__45__10206" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10201" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__7__45__RXN" name="Kynurenine--oxoglutarate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aspC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AspC )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.7</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__476" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tktA ) or ( tktA ) or ( tktA ) or ( tktB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( TktA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__IDITOL__45__2__45__DEHYDROGENASE__45__RXN" name="L-iditol 2-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__369" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9569" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R422__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( camP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxygenating component of camphor 1,2-monooxygenase subunit and NADH oxidase )</html:p>
<html:p>SUBSYSTEM: adamantanone degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__744" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__746" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Quinones__124___TO___124__Reduced__45__Quinones__124___COF_RXN" name="|Quinones|_TO_|Reduced-Quinones|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Reduced__45__Quinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6261" name="adenosylcobinamide-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiB ) or ( cobC and cobD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA and NA and adenosylcobinamide-phosphate synthase &amp;alpha; component )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__691" stoichiometry="1"/>
      <speciesReference species="R__45__1__45__AMINOPROPAN__45__2__45__YL__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__TYROSINE__45__PHOSPHATASE__45__RXN" name="Protein-tyrosine-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( etp ) or ( pphB ) or ( wzb ) or ( pphA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphotyrosine-protein phosphatase ) or ( NA ) or ( NA ) or ( protein phosphatase 1 modulates phosphoproteins, signals protein misfolding )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.48</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALGLDAPAALIG__45__RXN" name="UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl- D-alanine ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( murF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C1" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__361" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rihA ) or ( rihC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ribonucleoside hydrolase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__OCTAPRENYLTRANSTRANSFERASE__45__RXN" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDSS2 and PDSS1 ) or ( sds1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decaprenyl diphosphate synthase subunit 1 and decaprenyl diphosphate synthase subunit 2 ) or ( solanesyl diphosphate synthase ) or ( solanesyl diphosphate synthase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: decaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: all trans undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: dodecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: nonaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: tridecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.11</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SOLANESYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__HEXANOLIDE__45__HYDROLYSIS__45__RXN" name="6-hexanolide hydrolysis" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( chnC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cyclohexanol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__101" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__102" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__363" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rihC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleoside hydrolase 3 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TARTRATE__45__DEHYDROGENASE__45__RXN" name="Tartrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tartrate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.93</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__66" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__366" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rihC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleoside hydrolase 3 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6981" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSTO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylarsonate reductase subunit )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYLARSINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYLARSINOUS__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTREDUCTOISOM__45__RXN" name="Ketol-acid reductoisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ilvC ) or ( ilvC ) or ( ilvC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetohydroxy-acid isomeroreductase subunit ) or ( NA ) or ( acetohydroxy acid isomeroreductase subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I (from threonine)</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__KETO__45__2__45__METHYLVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R6__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gallate degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__17" stoichiometry="1"/>
      <speciesReference species="OH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__19" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__17__46__1__46__1__45__RXN" name="CDP-4-dehydro-6-deoxyglucose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ascD and ascC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase reductase and CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehydrase )</html:p>
<html:p>SUBSYSTEM: superpathway of CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.1</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__658" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1078" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICONUCADENYLYLTRAN__45__RXN" name="Nicotinate-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NMA2 ) or (  ) or ( nadD ) or ( NMA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( nicotinate nucleotide adenylyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling (plants)</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSINE__45____45__PYRUVATE__45__6__45__AMINOTRANSFERASE__45__RXN" name="Lysine--pyruvate 6-aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation IX</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.71</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OCTAPRENYL__45__4__45__OHBENZOATE__45__DECARBOX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiD ) or ( ubiX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-octaprenyl-4-hydroxybenzoate carboxy-lyase monomer ) or ( 3-octaprenyl-4-hydroxybenzoate decarboxylase together with UbiG )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OCTAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYLPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_7__45__ALPHA__45__HYDROXYSTEROID__45__DEH__45__RXN" name="7-&amp;alpha;-hydroxysteroid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hdhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( HdhA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.159</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLANATE2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1241" name="coniferyl-aldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( REF1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ferulate and sinapate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.68</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CONIFERYL__45__ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLYLSULFATE__45__REDUCTASE__45__RXN" name="Adenylylsulfate reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aprA and aprB ) or (  ) or (  ) or ( AprB and AprA ) or (  ) or ( aprA and aprB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylylsulfate reductase &amp;beta; subunit and adenylylsulfate reductase &amp;alpha; subunit ) or ( NA ) or ( NA ) or ( adenylylsulfate reductase &amp;beta; subunit and adenylylsulfate reductase &amp;alpha; subunit and adenylylsulfate reductase &amp;alpha; subunit ) or ( adenylylsulfate reductase &amp;beta; subunit and adenylylsulfate reductase &amp;alpha; subunit ) or ( APS reductase &amp;alpha; subunit and APS reductase &amp;beta; subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sulfite oxidation II</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur metabolism (Desulfocapsa sulfoexigens)</html:p>
<html:p>SUBSYSTEM: sulfate reduction IV (dissimilatory)</html:p>
<html:p>SUBSYSTEM: sulfite oxidation III</html:p>
<html:p>SUBSYSTEM: sulfate reduction III (dissimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of thiosulfate metabolism (Desulfovibrio sulfodismutans)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur oxidation (Acidianus ambivalens)</html:p>
<html:p>PROTEIN_CLASS: 1.8.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6266" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cas2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( clavaminate synthase )</html:p>
<html:p>SUBSYSTEM: clavulanate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.21</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROCLAVAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROCLAVAMINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6267" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cas2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( clavaminate synthase )</html:p>
<html:p>SUBSYSTEM: clavulanate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.21</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROCLAVAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CLAVAMINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6268" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis III (plants)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETAINE__45__ALDEHYDE__45__HYDRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9544" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: stearate biosynthesis I (animals)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10260" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10261" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8498" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( StDES )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: divinyl ether biosynthesis I (9-LOX)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8678" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8680" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9546" name="Enoyl-[acyl-carrier protein] reductase (NADPH, B-specific)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: stearate biosynthesis I (animals)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10262" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="STEAROYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9545" name="a 3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: stearate biosynthesis I (animals)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.59</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10261" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10262" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8499" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AOS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 9-LOX and 9-AOS pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8677" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8681" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9581" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rifN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3-amino-5-hydroxybenzoate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of rifamycin B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10224" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10225" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6242" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AmAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aureusidin synthase )</html:p>
<html:p>SUBSYSTEM: aurone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.21.3.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2982" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPMANNACADEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rffD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__MANNACA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9584" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rifH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3-amino-5-hydroxybenzoate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of rifamycin B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__10227" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10228" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__13__46__11__46__6__45__RXN" name="3-hydroxyanthranilate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( BNA1 ) or ( nbaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyanthranilate 3,4-dioxygenase subunit ) or ( NA ) or ( 3-hydroxyanthranilate 3,4-dioxygenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation I</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLCNACEPIM__45__RXN" name="UDP-N-acetylglucosamine 2-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rffE ) or ( mnaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: teichoic acid (poly-glycerol) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TEICHOICSYN4__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tagF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: teichoic acid (poly-glycerol) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.12</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Teichoic__45__P__45__Gro__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__606" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="__124__Teichoic__45__P__45__Gro__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RETICULINE__45__OXIDASE__45__RXN" name="Reticuline oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( BBE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( berberine bridge enzyme ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>SUBSYSTEM: berberine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.21.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__RETICULINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__SCOULERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__117__45__RXN" name="(S)-scoulerine 9-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SMT ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( scoulerine 9-O-methyltransferase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: berberine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.117</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__SCOULERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__TETRAHYDROCOLUMBAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9579" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rifK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-amino-5-hydroxybenzoate synthase subunit )</html:p>
<html:p>SUBSYSTEM: kanosamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of rifamycin B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10220" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10223" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9578" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rifL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: kanosamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of rifamycin B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10220" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9577" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: furaneol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10198" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="CPD__45__10216" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENTMULTI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( entF and entD and entB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( EntE and EntD and EntB and NA )</html:p>
<html:p>SUBSYSTEM: enterobactin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDROXYBENZOATE" stoichiometry="3"/>
      <speciesReference species="SER" stoichiometry="3"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ENTEROBACTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__NITROPROPANE__45__DIOXYGENASE__45__RXN" name="2-nitropropane dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ncd-2 ) or ( 2-NPD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-nitropropane dioxygenase subunit ) or ( 2-nitropropane dioxygenase subunit )</html:p>
<html:p>SUBSYSTEM: 2-nitropropane degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.32</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ACETONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__244" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="2"/>
      <speciesReference species="ACETONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9574" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FaOMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: furaneol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10214" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KYNURENINASE__45__RXN" name="Kynureninase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kyn )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynureninase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation I (via anthranilate)</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SQUALENE__45__MONOOXYGENASE__45__RXN" name="Squalene monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG1 ) or ( SE ) or ( SQLE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene monooxygenase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLGLUTACONYL__45__COA__45__HYDRATASE__45__RXN" name="Methylglutaconyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AUH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylglutaconyl-CoA hydratase subunit )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.18</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: diploterol and cycloartenol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOPAN__45__22__45__OL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXY__45__KYNURENINASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BNA5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1223" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SQD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-sulfoquinovose synthase )</html:p>
<html:p>SUBSYSTEM: sulfolipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.13.1.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__SULFOQUINOVOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GERANYL__45__DIPHOSPHATE__45__CYCLASE__45__RXN" name="geranyl-diphosphate cyclase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BDS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: bornyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__215" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1225" name="Digalactosyldiacylglycerol synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DGD2 ) or ( DGD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-galactose:MGDG galactosyltransferase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.241</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Galactosyl__45__12__45__diacyl__45__glycerols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Galactosyl__45__galactosyl__45__diacyl__45__glycerols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9565" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FaQR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: furaneol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="CPD__45__10208" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10209" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1224" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SQD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-sulfoquinovose:DAG sulfoquinovosyltransferase )</html:p>
<html:p>SUBSYSTEM: sulfolipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="UDP__45__SULFOQUINOVOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFOQUINOVOSYLDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CREATININE__45__DEAMINASE__45__RXN" name="Creatinine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( codA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( creatinine deiminase subunit )</html:p>
<html:p>SUBSYSTEM: creatinine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.21</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CREATININE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__METHYLHYDANTOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1226" name="Galactolipid galactosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.184</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Galactosyl__45__12__45__diacyl__45__glycerols__124__" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="CPD__45__10363" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9567" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FaQR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: furaneol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="CPD__45__10207" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10210" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNONDEHYDRAT__45__RXN" name="Mannonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( uxuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hexuronide and hexuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide and D-glucuronate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__MANNONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHEAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hisC ) or ( aspC ) or ( tyrB ) or ( ARO8 ) or (  ) or ( aroJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( AspC ) or ( TyrB ) or ( aromatic amino acid aminotransferase I ) or ( phenylalanine transaminase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation III</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4761" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: formononetin conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.170</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMONONETIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ONONIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4762" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: formononetin conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.115</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ONONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4562" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MONOPHENOL__45__MONOOXYGENASE__45__RXN" name="Monophenol monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit 1 tyrosinase and subunit 2 tyrosinase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betalain biosynthesis (to betalamic acid)</html:p>
<html:p>SUBSYSTEM: betacyanin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOPAQUINONE" stoichiometry="1"/>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4763" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: formononetin conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4562" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ONONIN" stoichiometry="1"/>
      <speciesReference species="MALONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4764" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: formononetin conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ONONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMONONETIN" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERPHOSPHA__45__RXN" name="Phosphoserine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( serB ) or ( Psph )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phosphoserines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Serines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHYLPROPIOTHETIN__45__DETHIOMETHYLASE__45__RXN" name="Dimethylpropiothetin dethiomethylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( dddL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of dimethylsulfoniopropionate degradation</html:p>
<html:p>SUBSYSTEM: dimethylsulfoniopropionate degradation I (cleavage)</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACRYLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SS__45__DIMETHYL__45__BETA__45__PROPIOTHETIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7670" stoichiometry="1"/>
      <speciesReference species="ACRYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Succinate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SSADH1 ) or ( yneI ) or ( ALDH5A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinic semialdehyde dehydrogenase ) or ( NA ) or ( succinate semialdehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation I</html:p>
<html:p>SUBSYSTEM: glutamate degradation III (via 4-aminobutyrate)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.24</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATESYNTH__45__RXN" name="dihydrofolate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHFS ) or ( folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__34__45__RXN" name="Glucose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GMPP ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-mannose pyrophosphorylase &amp;alpha; subunit and GDP-mannose pyrophosphorylase &amp;beta; subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.34</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZYL__45__ALC__45__DEHYDROGENASE__45__RXN" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylB ) or ( ntnD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzyl alcohol dehydrogenase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation IV (aerobic) (via catechol)</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R361__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ntnA and ntnM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-nitrotoluene monooxygenase reductase component and 4-nitrotoluene monooxygenase hydroxylase component )</html:p>
<html:p>SUBSYSTEM: 4-nitrotoluene degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__701" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__702" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__66__45__RXN" name="Mycothiol-dependent formaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Rv2259 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mycothiol-dependent formaldehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation III (mycothiol-dependent)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.66</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLMYCOTHIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__121" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINEPHEN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MAO ) or ( tynA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( TynA )</html:p>
<html:p>SUBSYSTEM: phenylethylamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of phenylethylamine degradation</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.21</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLETHYLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__72__45__RXN" name="Indoleacetylglucose--inositol O-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IAA-myo-inositol synthase )</html:p>
<html:p>SUBSYSTEM: IAA conjugate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.72</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__1102" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__165" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2001" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( arnT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-amino-4-deoxy-L-arabinose (L-Ara4N) transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1189" stoichiometry="2"/>
      <speciesReference species="KDO2__45__LIPID__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__P" stoichiometry="2"/>
      <speciesReference species="L__45__ARA4N__45__MODIFIED__45__KDO2__45__LIPID__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1442" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G24100 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UGT74B1 )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from tryptophan</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.195</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1861" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1862" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1443" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtST5a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( desulfoglucosinolate sulfotransferase )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from tryptophan</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.-</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PAP</html:p>
<html:p>SIDE: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1862" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1863" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSALDOL__45__RXN" name="Transaldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( talB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transaldolase B )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__117__45__RXN" name="Dolichyl-phosphate &amp;beta;-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.117</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1441" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At4g31500 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYP83B1 )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from tryptophan</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="INDOLE__45__3__45__ACETALDOXIME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7547" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPDEHYDRHAMEPIM__45__RXN" name="dTDP-4-dehydrorhamnose 3,5-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfbC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP_TO_GDP_COF_RXN" name="GTP_TO_GDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCSEMIALDDEHYDROG__45__RXN" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( yneI ) or ( UGA2 ) or ( gabD ) or (  ) or ( gabD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( succinate semialdehyde dehydrogenase ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation I</html:p>
<html:p>SUBSYSTEM: glutamate degradation IX (via 4-aminobutyrate)</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPH_TO_NADP_COF_RXN" name="NADPH_TO_NADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHFS/FPGS4 ) or ( DHFS/FPGS2 ) or ( DHFS/FPGS3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MUCONOLACTONE__45__DELTA__45__ISOMERASE__45__RXN" name="Muconolactone &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( catC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( muconolactone isomerase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: aromatic compounds degradation via &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: catechol degradation to &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: catechol degradation III (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__741" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXOADIPATE__45__ENOL__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__21__45__RXN" name="Clavaminate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cas2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( clavaminate synthase )</html:p>
<html:p>SUBSYSTEM: clavulanate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.21</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYAMIDINOPROCLAVAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMIDINOPROCLAVAMINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4731" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 7-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4610" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAMPYR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( serC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SerC )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3OH__45__4P__45__OH__45__ALPHA__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__PHOSPHONOOXY__45__THREONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4732" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 9-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4611" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4730" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 9-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4604" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4608" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__12__46__18__45__RXN" name="Biphenyl 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bphAa and bphAd and bphAc and bphAb ) or ( etbAb1 and etbAa1 ) or ( tecA4 and tecA2 and tecA3 and tecA1 ) or ( etbAc and etbAb2 and etbAa2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biphenyl 2,3-dioxygenase beta subunit and biphenyl 2,3-dioxygenase, reductase and biphenyl 2,3-dioxygenase alpha subunit and biphenyl 2,3-dioxygenase, ferredoxin component ) or ( ethylbenzene dioxygenase beta subunit and ethylbenzene dioxygenase alpha subunit ) or ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit ) or ( ethylbenzene dioxygenase alpha subunit and ethylbenzene dioxygenase beta subunit and ethylbenzene dioxygenase, ferredoxin component )</html:p>
<html:p>SUBSYSTEM: biphenyl degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.18</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIPHENYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__3__45__PHENYLCYCLOHEXA__45__35__45__DIENE__45__12__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4737" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73C5 ) or ( UGT85A1 ) or ( UGT73C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins-O-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4616" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4621" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( frlC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructoselysine 3-epimerase )</html:p>
<html:p>SUBSYSTEM: fructoselysine and psicoselysine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PSICOSELYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSELYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4735" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73C5 ) or ( cisZOG2 ) or ( UGT85A1 ) or ( cisZOG1 ) or ( UGT73C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins-O-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.215</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4620" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4736" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 7-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4614" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4622" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__99__46__37__45__RXN" name="Taxadiene 5-&amp;alpha;-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( T5&amp;alpha;-H )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( taxadiene 5&amp;alpha;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: taxol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.37</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAXA__45__411__45__DIENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAXA__45__42011__45__DIEN__45__5A__45__OL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4733" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 7-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4734" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT76C2 ) or ( UGT76C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cytokinins 9-N-glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4619" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2023" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mnmA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__THIOURIDINE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2022" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC1 ) or ( PDC5 ) or ( poxB ) or ( PDC6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate decarboxylase 1 subunit ) or ( pyruvate decarboxylase 2 subunit ) or ( pyruvate oxidase monomer ) or ( pyruvate decarboxylase 3 subunit )</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSPSYN__45__RXN" name="glutathionylspermidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gspS ) or ( TryS ) or ( gsp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( Gsp )</html:p>
<html:p>SUBSYSTEM: glutathionylspermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONYLSPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R309__45__RXN" name="Aliphatic nitrilase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aliphatic nitrilase subunit )</html:p>
<html:p>SUBSYSTEM: acrylonitrile degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.7</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLONITRILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3645" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.46</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOCHANIN__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLPHOSPHATASE__45__RXN" name="Acylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yccX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acylphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acyl__45__Phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3642" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.150</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3521" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BADEL6OXRED__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bile acid &amp;Delta;6-oxidoreductase )</html:p>
<html:p>SUBSYSTEM: cholate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OXO__45__DELTA46__45__CHOLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXO__45__DELTA4__45__DEOXYCHOLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2061" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ldcA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L,D-carboxypeptidase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__MURNAC__45__TETRAPEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALA__45__GLU__45__LIG__45__RXN" name="UDP-N-acetylmuramoylalanine--D-glutamate ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( murD ) or ( murD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__ACETYLMURAMOYL__45__ALA" stoichiometry="1"/>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LANOSTEROL__45__SYNTHASE__45__RXN" name="Lanosterol synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG7 ) or ( LSS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-oxidosqualene-lanosterol cyclase ) or ( lanosterol synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATESYN__45__RXN" name="Thymidylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( DHFR-TS ) or ( thyA ) or ( THY-1 ) or ( THY-2 ) or ( thyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DHFR-TS subunit ) or ( NA ) or ( thymidylate synthase ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.45</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: DIHYDROFOLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLULOKIN__45__RXN" name="Xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xkiA ) or (  ) or (  ) or (  ) or ( xylB ) or ( dalK ) or ( atlB ) or ( XYLB ) or ( mtlY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-xylulose kinase subunit ) or ( NA ) or ( NA ) or ( NA ) or ( xylulokinase ) or ( D-xyulokinase subunit ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>SUBSYSTEM: xylose degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: D-arabitol degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYCYCLOHEXADIENYL__45__DEHYDRATASE__45__RXN" name="Carboxycyclohexadienyl dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine and tyrosine biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.91</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__659" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2044" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( paaH ) or ( paaF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( predicted 3-hydroxy-acyl-CoA dehydrogenase of phenylacetate degradation ) or ( putative enoyl-CoA hydratase/isomerase of phenylacetate degradation )</html:p>
<html:p>SUBSYSTEM: phenylacetate degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of phenylethylamine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYADIPYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__" stoichiometry="2"/>
      <speciesReference species="_3__45__KETO__45__ADIPYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2043" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( paaG ) or ( maoC ) or ( paaJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative enoyl-CoA hydratase/isomerase of phenylacetate degradation ) or ( putative ring-cleavage enzyme of phenylacetate degradation ) or ( &amp;beta;-ketoadipyl-CoA thiolase )</html:p>
<html:p>SUBSYSTEM: phenylacetate degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of phenylethylamine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__DIHYDRODIOL__45__DERIV__45__PHEAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXYADIPYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__12__45__DIOXYGENASE__45__RXN" name="Catechol 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( catA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of catechol 1,2-dioxygenase )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: aromatic compounds degradation via &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: catechol degradation to &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: catechol degradation III (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__CIS__45__MUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__110__45__RXN" name="Sterigmatocystin 7-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( omtA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( O-methyltransferase II )</html:p>
<html:p>SUBSYSTEM: aflatoxins B1 and G1 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.110</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="STERIGMATOCYSTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7157" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOINDEHYDROG__45__A__45__RXN" name="Acetoin dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( DCXR ) or ( idnO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( L-xylulose reductase subunit ) or ( 5-keto-D-gluconate 5-reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEHYDDEOXGALACTKIN__45__RXN" name="2-dehydro-3-deoxygalactonokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dgoK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: D-galactonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.58</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GALACTONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDRO__45__DEOXY__45__GALACTONATE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1403" name="indoleacetaldoxime dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indole-3-acetaldoxime hydrolyase subunit )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__ACETALDOXIME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLEYL__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1402" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At2g22330 ) or ( At4g39950 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYP79B3 ) or ( CYP79B2 )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from tryptophan</html:p>
<html:p>SUBSYSTEM: camalexin biosynthesis</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__ACETALDOXIME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1407" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Igl ) or ( Bx1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indole-3-glycerol phosphate lyase ) or ( indole-3-glycerol phosphate lyase )</html:p>
<html:p>SUBSYSTEM: DIBOA / DIMBOA biosynthesis</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLYCEROL__45__3P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1405" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( yucca )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Yucca )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__HYDROXYL__45__TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1404" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nit2 ) or ( nit1 ) or ( nit3 ) or ( AFAAANL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Nit2 ) or ( Nit1 ) or ( Nit3 ) or ( nitrilase subunit )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis V</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLEYL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRTRANS__45__RXN" name="Anthranilate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trpD ) or ( trpGD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anthranilate synthase component II ) or ( anthranilate synthase component II )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__5__45__PHOSPHORIBOSYL__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2081" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( napC and napA and napG and napB and napH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferredoxin-type protein and large subunit of periplasmic nitrate reductase, molybdoprotein and ferredoxin-type protein and cytochrome c protein and small subunit of periplasmic nitrate reductase, cytochrome c550 protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3661" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nbzAa and nbzAc and nbzAb and nbzAd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxygenaseNBZ&amp;alpha; and ferredoxinNBZ and oxygenaseNBZ&amp;beta; and reductaseNBZ )</html:p>
<html:p>SUBSYSTEM: nitrobenzene degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZENE__45__NO2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4781" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EAS34 ) or ( TEAS ) or ( EAS12 ) or ( EAS37 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: capsidiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4664" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1__45__KINASE__45__RXN" name="Myo-inositol 1-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lpa3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lipid-independent phytate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.64</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOINDEHYDROG__45__RXN" name="acetoin dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( budC ) or ( budC ) or ( butA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetoin reductase subunit ) or ( acetoin reductase subunit ) or ( 2,3-butanediol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.5</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACETYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__118" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Lass5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( LAG1 homolog, ceramide synthase 5 )</html:p>
<html:p>SUBSYSTEM: ceramide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3DJ__45__82" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2__45__METHYLENE__45__THMPT__45__DEHYDRO__45__RXN" name="N5,N10-methenyltetrahydromethanopterin hydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hmd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Hmd )</html:p>
<html:p>SUBSYSTEM: methanogenesis from CO2</html:p>
<html:p>PROTEIN_CLASS: 1.12.98.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="METHENYLTETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENETETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOATE__45__DEIMINASE__45__RXN" name="Allantoate deiminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( allC ) or ( AtAAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( allantoate amidohydrolase subunit ) or ( allantoate amidohydrolase ) or ( allantoate amidohydrolase monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation in plants</html:p>
<html:p>SUBSYSTEM: allantoin degradation IV (anaerobic)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate II (ammonia producing)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate III</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.9</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__598" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYROID__45__HORMONE__45__AMINOTRANSFERASE__45__RXN" name="Thyroid-hormone aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-triiodothyronine aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.26</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LIOTHYRONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__176" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNN__45__404" name="indole acetamide hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tms2 ) or ( iaaH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis IV</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis VI (via indole-3-acetamide)</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__237" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHEBDEAMID__45__RXN" name="Protein-glutamine glutaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cheB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CheB-Pasp )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.44</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__L__45__glutamine__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Glutamates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__273__45__RXN" name="Vellosimine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.273</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VELLOSIMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__DEOXYSARPAGINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERCURY__45__II__45__REDUCTASE__45__RXN" name="Mercury (II) reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( merA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mercuric ion reductase subunit )</html:p>
<html:p>SUBSYSTEM: phenylmercury acetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.16.1.1</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HG__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HG0" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBPSYN__45__RXN" name="carbamoyl-phosphate synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( carA and carB ) or ( CAD ) or ( carB and carA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( small subunit and large subunit ) or ( CAD protein ) or ( CarB and CarA )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__24__45__RXN" name="2&apos;-deoxymugineic-acid 2&apos;-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ids3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hydroxylated mugineic acid phytosiderophore biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.24</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7227" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7231" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDROG__45__RXN" name="Prephenate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tyrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TyrA )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARAGHYD__45__RXN" name="Asparaginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( ansA ) or ( ansB ) or ( iaaA ) or (  ) or ( ansB1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-asparaginase subunit ) or ( AnsA ) or ( AnsB ) or ( &amp;alpha; cleavage product of IaaA and &amp;beta; cleavage product of IaaA ) or ( NA ) or ( L-asparaginase subunit ) or ( L-asparaginase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine.</html:p>
<html:p>SUBSYSTEM: asparagine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__218" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPISTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_572428__45__ERGOSTATRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREONINE__45__ALDOLASE__45__RXN" name="Threonine aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLY1 ) or ( ltaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-threonine aldolase subunit ) or ( LtaA )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: threonine degradation IV</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5165" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MMR ) or ( MNR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( menthol dehydrogenase ) or ( neomenthol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4943" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4944" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5166" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MMR ) or ( MNR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( menthol dehydrogenase ) or ( neomenthol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4943" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4945" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__2__45__DIOXYGENASE__45__RXN" name="Tryptophan 2&apos;-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 2&apos;-dioxygenase &amp;alpha; subunit and tryptophan 2&apos;-dioxygenase &amp;gamma; subunit and tryptophan 2&apos;-dioxygenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.99.3</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__INDOLYLGLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATE__45__DEHYDROGENASE__45__RXN" name="Nicotinate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation II</html:p>
<html:p>SUBSYSTEM: nicotinate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__HYDROXY__45__NICOTINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3901" name="glutamate-putrescine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( puuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate-putrescine ligase )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: putrescine degradation II</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__GLUTAMYL__45__PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYBENZOATE__45____45__COA__45__LIGASE__45__RXN" name="4-hydroxybenzoate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybenzoate-CoA ligase )</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: phenol degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.27</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__201" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__67__45__RXN" name="Galactinol-raffinose galactosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STS1 ) or (  ) or ( STS1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: stachyose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.67</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
      <speciesReference species="CPD__45__1099" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__170" stoichiometry="1"/>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lysZ ) or ( lysZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N2__45__ACETYL__45__ALPHA__45__AMIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2ACETYL__45__ALPHA__45__NP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lysX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__ACETYL__45__ALPHA__45__AMIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__METHYLTHIORIBOSE__45__KINASE__45__RXN" name="5-methylthioribose kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mtrk ) or ( MTK1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.100</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__560" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5185" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lysK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N2-acetyl-L-lysine deacetylase subunit )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LYS" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5184" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lysJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N2-acetyl-&amp;alpha;-aminoadipate semialdehyde transaminase subunit )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__AAA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lysY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N2ACETYL__45__ALPHA__45__NP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__AAA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__227" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-22 sterol desaturase )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_572428__45__ERGOSTATRIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_57222428__45__ERGOSTATETRAENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2562" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( G-TMT ) or ( slr0089 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: vitamin E biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.95</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA__45__TOCOPHEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETA__45__TOCOPHEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2561" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTE1 ) or ( slr1737 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tocopherol cyclase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: vitamin E biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MPBQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA__45__TOCOPHEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGDECARBOX__45__RXN" name="Arginine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( speA ) or ( adiA ) or ( speA ) or ( speA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( Adi ) or ( arginine decarboxylase, biosynthetic ) or ( SpeA )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine dependent acid resistance</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: arginine degradation III (arginine decarboxylase/agmatinase pathway)</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.19</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AGMATHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="M__45__CRESOL__45__METHYLCATECHOL__45__RXN" name="m-cresol-methylcatechol" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tbuB and tbuV and tbuA2 and tbuA1 and tbuC and tbuU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( toluene 3-monooxygenase ferredoxin subunit and toluene 3-monooxygenase hydroxylase &amp;gamma; subunit and toluene 3-monooxygenase hydroxylase &amp;beta; subunit and toluene 3-monooxygenase effector subunit and toluene 3-monooxygenase reductase subunit and toluene 3-monooxygenase hydroxylase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate (via 4-methylcatechol)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation II (aerobic) (via 4-methylcatechol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__METHYLCATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R363__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ntnC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrotoluene degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.29</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__703" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__704" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTPRATPHYD__45__RXN" name="Phosphoribosyl-ATP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At-IE ) or ( hisI ) or ( hisI-E )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.31</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__3__46__3__46__10__45__RXN" name="5-carboxymethyl-2-hydroxymuconate &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hpaF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__784" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__785" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPDEHYDROG__45__RXN" name="Mannitol-1-phosphate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mtlD ) or ( mtlD ) or ( mtlD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: superpathway of hexitol degradation</html:p>
<html:p>SUBSYSTEM: mannitol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.17</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNITOL__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Aspartate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AT1G14810 ) or ( asd ) or ( asd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( aspartate semialdehyde dehydrogenase ) or ( aspartate semialdehyde dehydrogenase subunit ) or ( Asd )</html:p>
<html:p>SUBSYSTEM: ectoine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis III</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis II</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (by sulfhydrylation)</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis VI</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.11</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCARGDIHYDRO__45__RXN" name="N-succinylarginine dihydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( astB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: arginine degradation II (AST pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.23</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__421" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__SUCCINYLORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5143" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( g-pin2 ) or ( g-&amp;beta;phe ) or ( TPS-Car ) or ( TPS-Pin ) or ( g-lim1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( limonene/&amp;alpha;-pinene synthase ) or ( &amp;beta;-phellandrene synthase ) or ( 3-carene synthase ) or ( pinene synthase ) or ( limonene synthase )</html:p>
<html:p>SUBSYSTEM: oleoresin monoterpene volatiles biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8768" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Protein__45__Dithiols__124___TO___124__Protein__45__Disulfides__124___COF_RXN" name="|Protein-Dithiols|_TO_|Protein-Disulfides|_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Dithiols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__11__45__RXN" name="1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtPLC1 ) or ( AtPLC2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AtPLC1 ) or ( AtPLC2 )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( puuB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-glutamylputrescine oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: putrescine degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: AMMONIUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAMMA__45__GLUTAMYL__45__PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMMONIUM" stoichiometry="1"/>
      <speciesReference species="GAMMA__45__GLUTAMYL__45__GAMMA__45__AMINOBUTYRALDEH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANPRIBOSYLTRAN__45__RXN" name="Xanthine-guanine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gpt )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.22</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3922" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( puuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-glutamyl-&amp;gamma;-aminobutyraldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: putrescine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAMMA__45__GLUTAMYL__45__GAMMA__45__AMINOBUTYRALDEH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9000" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__1__46__6__45__RXN" name="biotin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bioB ) or ( bioB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin synthase monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis III</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.6</html:p>
<html:p>SIDE: __124__Sulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: CH33ADO</html:p>
<html:p>SIDE: __124__Unsulfurated__45__Sulfur__45__Acceptors__124__</html:p>
<html:p>SIDE: MET</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="DETHIOBIOTIN" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
      <speciesReference species="__124__Unsulfurated__45__Sulfur__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5164" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4942" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4943" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.81</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4942" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1909" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5161" name="(-)-isopiperitenone reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ISPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.82</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1090" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4941" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINEPHOSPHOTRANSFERASE__45__RXN" name="Ethanolaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AAPT2 ) or ( AAPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminoalcoholphosphotransferase ) or ( aminoalcoholphosphotransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylethanolamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.1</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINATE__45__5__45__DEHYDROGENASE__45__RXN" name="Quinate 5-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ydiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.24</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2581" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP98A35 ) or ( CYP98A36 ) or ( REF8 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( p-coumaroyl ester 3&apos;-hydroxylase ) or ( NA ) or ( p-coumaroyl shikimate/quinate 3&apos;-hydroxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis II</html:p>
<html:p>SUBSYSTEM: simple coumarins biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__412" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAFFEOYLSHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__203" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FECOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPISTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROPORIIIMETHYLTRANSA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( corA ) or ( cysG ) or ( cobA ) or ( cysG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen-III C-methyltransferase subunit ) or ( CysG ) or ( CobA ) or ( uroporphyrinogen-III C-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: factor 430 biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__93__45__RXN" name="(+)-abscisic acid 8&apos;-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP707A1 ) or ( CYP707A2 ) or ( CYP707A3 ) or ( CYP707A4 ) or ( ABA8&apos;OH-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phaseic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.93</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__693" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7234" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TAURINE__45__DEHYDROGENASE__45__RXN" name="Taurine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tauY and tauX ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( taurine dehydrogenase subunit and taurine dehydrogenase subunit ) or ( taurine dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: taurine degradation II</html:p>
<html:p>SUBSYSTEM: superpathway of taurine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.4.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFOACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLTHFGLUSYNTH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( folC ) or ( DHFS/FPGS4 ) or ( DHFS/FPGS2 ) or ( folC ) or ( DHFS/FPGS3 ) or (  ) or ( folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpoly-&amp;gamma;-synthetase subunit ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( folylpoly-&amp;alpha;-glutamate synthetase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__70__45__RXN" name="Sterol 14-demethylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51G1 ) or ( OBT14DM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OBTUSIFOLIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R10__45__RXN" name="3-hexulose-6-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hps ) or ( rmpA ) or ( rmpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexulose-6-phosphate synthase subunit ) or ( hexulose-6-phosphate synthase subunit ) or ( hexulose-6-phosphate synthase subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.43</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__26" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__1__45__RXN" name="Nicotinamide-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nadM ) or ( nadR ) or ( NMA2 ) or ( nadR ) or ( nadM ) or ( NMA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotineamide mononucleotide adenylyltransferase subunit ) or ( NA ) or ( NA ) or ( NadR transcriptional repressor ) or ( nicotinamide mononucleotide adenylyltransferase subunit ) or ( nicotinate nucleotide adenylyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis III</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway III</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FLAVONE__45__APIOSYLTRANSFERASE__45__RXN" name="Flavone apiosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavone apiosyltransferase )</html:p>
<html:p>SUBSYSTEM: apigenin glycosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.25</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__APIOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APIGENIN__45__7__45__O__45__BETA__45__D__45__GLUCOSIDE" stoichiometry="1"/>
      <speciesReference species="UDP__45__APIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__O__45__BETA__45__D__45__APIOFURANOSYL__45__12__45__BETA__45__D__45__GLU" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__170" name="Aromatic-L-amino-acid decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ddc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-DOPA decarboxylase )</html:p>
<html:p>SUBSYSTEM: serotonin and melatonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__HYDROXY__45__TRYPTOPHAN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SEROTONIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENZRXN__45__201__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTANAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLGLUTPREDUCT__45__RXN" name="N-acetyl-&amp;gamma;-glutamyl-phosphate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG5,6 ) or ( argC ) or ( argC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__GLUTAMYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__469" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOPHOSPHORYL__45__RXN" name="glycogen phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glgP ) or ( GPH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GlgP ) or ( glycogen phosphorylase subunit )</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3942" name="Gamma-glutamyl-gamma-aminobutyrate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( puuD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-glutamyl-&amp;gamma;-aminobutyrate hydrolase )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: putrescine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.94</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9000" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R524__45__RXN" name="Cyanate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cynS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyanase monomer )</html:p>
<html:p>SUBSYSTEM: cyanate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.104</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="CPD__45__69" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__NUCLEOTID__45__RXN" name="5&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( surE ) or ( yjjG ) or ( nagD ) or ( ushA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( broad specificity 5&apos;(3&apos;)-nucleotidase and polyphosphatase ) or ( pyrimidine nucleotidase ) or ( ribonucleotide monophosphatase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPISOM__45__RXN" name="Mannose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( PH0925 ) or ( algA ) or (  ) or ( manA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomannose isomerase ) or ( phosphomannose isomerase ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: D-mannose degradation</html:p>
<html:p>SUBSYSTEM: mannitol biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis I (L-galactose pathway)</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis II</html:p>
<html:p>SUBSYSTEM: mannitol degradation II</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R313__45__RXN" name="Nitrile hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrile hydratase &amp;beta; subunit and nitrile hydratase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: aldoxime degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.84</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__CYANOPYRIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PCP4MONO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pentachlorophenol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PENTACHLOROPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRACHLOROHYDROQUINONE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRDABST__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( prdB and prdA and prdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 45-kDa subunit and 26-kDa subunit and 23-kDa subunit )</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>PROTEIN_CLASS: 1.21.4.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__PROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINOPENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__LACTDEHYDROGFMN__45__RXN" name="lactate oxidation" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lldD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: L-lactaldehyde degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of fucose and rhamnose degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation IV</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hel ) or ( nadN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NAD pyrophosphatase )</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling (plants)</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__NAD__43____45__RXN" name="DNA ligase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ligB ) or ( ligA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA ligase ) or ( DNA ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MEVALONATE__45__KINASE__45__RXN" name="Mevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( erg12 ) or ( MVK ) or (  ) or ( MVK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Erg12 ) or ( NA ) or ( NA ) or ( mevalonate kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.36</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__292" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox1 ) or ( GA2ox3 ) or ( GA2ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6224" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__632" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYKIN__45__RXN" name="Diacylglycerol kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dgkA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DgkA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.107</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THF_TO_10__45__FORMYL__45__THF_COF_RXN" name="THF_TO_10-FORMYL-THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BTUR2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobA ) or ( cobO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)yrinic acid a,c-diamide adenosyltransferase subunit ) or ( CobO )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="COBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISPH2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IspH ) or ( ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__3__46__35__45__RXN" name="Salutaridine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: morphine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.4</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__RETICULINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SALUTARIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__99__46__28__45__RXN" name="Glucose--fructose oxidoreductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gfo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-fructose oxidoreductase )</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.28</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aldB ) or ( ALD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( magnesium-activated aldehyde dehydrogenase, cytosolic )</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate VIII</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.4</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__CYANOALANINE__45__HYDRATASE__45__RXN" name="3-cyanoalanine hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At5g22300 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-cyano-L-alanine hydrolase )</html:p>
<html:p>SUBSYSTEM: cyanide detoxification</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.65</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__603" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__OXOPROLINASE__45__ATP__45__HYDROLYSING__45__RXN" name="5-oxoprolinase (ATP-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( Oplah )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-oxo-L-prolinase small subunit and 5-oxo-L-prolinase large subunit ) or ( 5-oxo-L-prolinase subunit )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__OXOPROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGININE__45__RACEMASE__45__RXN" name="Arginine racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginine racemase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__220" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLACYLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ECHS1 ) or ( ech )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( short chain enoyl-CoA hydratase subunit ) or ( enoyl-CoA hydratase subunit )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__123__45__RXN" name="Inositol 1-&amp;alpha;-galactosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GolS-2 ) or (  ) or ( GolS ) or ( GolS-1 ) or ( GolS-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: stachyose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.123</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__458" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LUMAZINESYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ribE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RibE )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__BUTANONE__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5822" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hel )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__43__45__RXN" name="Nicotianamine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( OsNAS2 ) or ( OsNAS3 ) or ( chln ) or ( NtNAS1 ) or ( OsNAS1 ) or ( hvnas1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: nicotianamine biosynthesis</html:p>
<html:p>SUBSYSTEM: 2&apos;-deoxymugineic acid phytosiderophore biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.43</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: _5__45__METHYLTHIOADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="3"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__463" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="3"/>
    </listOfProducts>
  </reaction>
  <reaction id="R165__45__RXN" name="Ureidoglycolate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( allD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: allantoin degradation IV (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.154</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__389" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5408" name="Myo-inositol-1(or 4)-monophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( suhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol monophosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__MYO__45__INOSITOL__45__1__45__MONOPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANOSINEKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( gsk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.73</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5405" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mrcA ) or ( mtgA ) or ( mrcB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptidoglycan synthetase; penicillin-binding protein 1A ) or ( biosynthetic peptidoglycan transglycosylase ) or ( MrcB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.129</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C6" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1178" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1179" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5402" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ynhG ) or ( ycbB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L,D-transpeptidase YnhG ) or ( L,D-transpeptidase YcbB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1182" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1183" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1185" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8369" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8167" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8168" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COLCYD__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tsaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-sulfobenzyl alcohol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: 4-toluenecarboxylate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CARBOXYBENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__CARBOXYBENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8368" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8168" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R81__45__RXN" name="Hexokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HQT ) or ( HCT ) or ( At5g48930 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.133</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: QUINATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__COUMAROYLQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URA__45__PHOSPH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( deoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DeoA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: URACIL</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8367" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2602" name="coniferyl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AtCAD4 ) or ( AtCAD5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( cinnamyl alcohol dehydrogenase ) or ( cinnamyl alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: capsiconiate biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.194</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CONIFERYL__45__ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CONIFERYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8366" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8167" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine monooxygenase &amp;alpha; subunit and carnitine monooxygenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: carnitine degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DL__45__CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRIMETHYLAMINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__5682" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8372" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DES )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;5 acyl-CoA desaturase )</html:p>
<html:p>SUBSYSTEM: &amp;Delta;5-eicosenoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9965" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTKIN__45__RXN" name="Glutamate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH18A1 ) or ( proB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ProB )</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__1__46__12__45__RXN" name="Trypanothione-disulfide reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trypanothione reductase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.12</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPANOTHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRYPANOTHIONE__45__DISULFIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMILACTDEHYDROG__45__RXN" name="3-(imidazol-5-yl)lactate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: imidazole-lactate degradation</html:p>
<html:p>SUBSYSTEM: histidine degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.111</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMIDAZOLE__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTAUR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Csad )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfinoalanine decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTEATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__178" name="&amp;delta;(24)-sterol C-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol 24-C-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.41</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FECOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Fatty__45__Acyl__45__CoA__124___TO_CO__45__A_COF_RXN" name="|Fatty-Acyl-CoA|_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8355" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73C6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8144" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9488" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( estA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: versicolorin B biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10170" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__10171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8358" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ttrC and ttrB and ttrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tetrathionate reductase &amp;gamma; subunit and tetrathionate reductase &amp;beta; subunit and tetrathionate reductase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of tetrathionate reduction (Salmonella typhimurium)</html:p>
<html:p>SUBSYSTEM: tetrathionate reduction I (to thiosulfate)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__14" stoichiometry="1"/>
      <speciesReference species="E__45__" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S2O3" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9489" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( versiconal hemiacetal acetate reductase )</html:p>
<html:p>SUBSYSTEM: versicolorin B biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10168" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10169" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8357" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GbCLH ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8155" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7061" stoichiometry="1"/>
      <speciesReference species="PHYTOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTEINE__45__AMINOTRANSFERASE__45__RXN" name="Cysteine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Got1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.3</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__MERCAPTO__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__3__46__4__45__RXN" name="(Carboxyethyl)arginine &amp;beta;-lactam-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bls )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: clavulanate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.4</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__N2__45__2__45__CARBOXYETHYLARGININE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYAMIDINOPROCLAVAMINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVOXID__45__RXN" name="Pyruvate dehydrogenase (cytochrome)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( poxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate oxidase monomer )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: pyruvate oxidation pathway</html:p>
<html:p>PROTEIN_CLASS: 1.2.2.2</html:p>
<html:p>SIDE: UBIQUINOL__45__8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UBIQUINONE__45__8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9494" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( vbs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( versiconal cyclase subunit )</html:p>
<html:p>SUBSYSTEM: versicolorin B biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10171" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10175" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__BETA__45__HYDROXYHYOSCYAMINE__45__EPOXIDASE__45__RXN" name="6-&amp;beta;-hydroxyhyoscyamine epoxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aah6h )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hyoscyamine 6&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: hyoscyamine and scopolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.14</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2202" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SCOPOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9493" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( estA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: versicolorin B biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10172" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10174" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8360" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-6 fatty acid desaturase, endoplasmic reticulum )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8157" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8158" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9492" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( moxY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( versiconal hemiacetal acetate synthase )</html:p>
<html:p>SUBSYSTEM: versicolorin B biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10169" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10172" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8361" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-3 fatty acid desaturase monomer )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8159" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYLCYC__45__RXN" name="Guanylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CGMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9491" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( versiconal hemiacetal acetate reductase )</html:p>
<html:p>SUBSYSTEM: versicolorin B biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10171" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10174" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__KINASE__45__RXN" name="Protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rdoA ) or ( yeaG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine/threonine protein kinase ) or ( protein kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8362" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrathionate reductiuon II (to trithionate)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CPD__45__552</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__14" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__552" stoichiometry="1"/>
      <speciesReference species="S8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8363" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8160" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8161" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9497" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ordA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: aflatoxins B1 and G1 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: METOH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7157" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__4592" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8364" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8161" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8162" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8365" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8163" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8164" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9495" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( verB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sterigmatocystin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10175" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10176" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9490" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( versiconal hemiacetal acetate reductase )</html:p>
<html:p>SUBSYSTEM: versicolorin B biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10170" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10172" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R211__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2K__45__ADIPATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__152" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7224" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: kievitone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.51</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6646" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIPHOSPHOMEVALONTE__45__DECARBOXYLASE__45__RXN" name="Diphosphomevalonate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MVD ) or ( MVD1 ) or ( MVD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diphosphomevalonate decarboxylase ) or ( Erg19 ) or ( mevalonate diphosphate decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8349" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyunsaturated fatty acid elongase )</html:p>
<html:p>SUBSYSTEM: arachidonate and eicosapentaenoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8119" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8121" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( phbB ) or (  ) or ( phaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetoacetyl-CoA reductase subunit ) or ( 3-hydroxybutyryl-CoA dehydrogenase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: polyhydroxybutyrate biosynthesis</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R401__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bisC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin sulfoxide reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.-.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="E__45__" stoichiometry="2"/>
      <speciesReference species="CPD__45__722" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8348" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( moeA ) or ( cnx1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: molybdenum cofactor biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__3</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3" stoichiometry="1"/>
      <speciesReference species="CPD__45__8122" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8123" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8347" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( des6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;6-acyl-lipid desaturase )</html:p>
<html:p>SUBSYSTEM: arachidonate and eicosapentaenoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLENIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8119" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2621" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCT ) or ( HCT ) or ( At5g48930 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CAFFEOYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SHIKIMATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CAFFEOYLSHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8346" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PPDES5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;5 desaturase )</html:p>
<html:p>SUBSYSTEM: arachidonate and eicosapentaenoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8120" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2622" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCT ) or ( HCT ) or ( At5g48930 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CAFFEOYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: QUINATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CAFFEOYLQUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7226" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: kievitone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6645" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8345" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyunsaturated fatty acid elongase )</html:p>
<html:p>SUBSYSTEM: arachidonate and eicosapentaenoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Gamma__45__linolenoyl__45__groups__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8120" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8344" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mog ) or ( cnx1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MogA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: molybdenum cofactor biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="CPD__45__4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8122" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9485" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-oxoaverantin cyclase subunit )</html:p>
<html:p>SUBSYSTEM: (1&apos;S,5&apos;S)-averufin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10167" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9484" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( adhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyaverantin dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: (1&apos;S,5&apos;S)-averufin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8354" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73C6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8138" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8143" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9487" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( moxY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( versiconal hemiacetal acetate synthase )</html:p>
<html:p>SUBSYSTEM: versicolorin B biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10168" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10170" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__AMINOLEVULINIC__45__ACID__45__SYNTHASE__45__RXN" name="5-aminolevulinic acid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hemA ) or ( hemT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-aminolevulinate synthase subunit ) or ( 5-aminolevulinate synthase 2 )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.37</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8351" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ABA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: molybdenum cofactor (sulfide) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="CPD__45__8123" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8124" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8352" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP710A2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8134" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4161" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9486" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cypX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: versicolorin B biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10167" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10168" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9481" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( avnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (1&apos;S)-averantin monooxygenase )</html:p>
<html:p>SUBSYSTEM: (1&apos;S,5&apos;S)-averufin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10163" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10164" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8350" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PPDES5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;5 desaturase )</html:p>
<html:p>SUBSYSTEM: arachidonate and eicosapentaenoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8121" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z8Z11Z14Z17Z__45__EICOSAPENTAENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9480" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nor-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (1&apos;S,5&apos;S)-averufin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10162" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10163" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9483" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( adhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyaverantin dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: (1&apos;S,5&apos;S)-averufin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10164" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9482" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( avnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (1&apos;S)-averantin monooxygenase )</html:p>
<html:p>SUBSYSTEM: (1&apos;S,5&apos;S)-averufin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of aflatoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10163" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10165" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINE__45__DEHYDROGENASE__45__RXN" name="Nicotine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ndhC and ndhB and ndhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NdhA and NdhB and NdhC )</html:p>
<html:p>SUBSYSTEM: nicotine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.4</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__125" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPIDXSYNTHESIS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cdh ) or ( lpxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__MYRISTOYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BISOHMYR__45__GLUCOSAMINYL__45__1P" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2NEOPTERINALDOL__45__RXN" name="Dihydroneopterin aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FOLB1 ) or ( folB ) or ( AY422466 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.25</html:p>
<html:p>SIDE: GLYCOLALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__NEO__45__PTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__OH__45__HYDROXYMETHYL__45__DIHYDROPTERIDINE" stoichiometry="1"/>
      <speciesReference species="GLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__CARBOXYMUCONOLACTONE__45__DECARBOXYLASE__45__RXN" name="4-carboxymuconolactone decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of 4-carboxymuconolactone decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: aromatic compounds degradation via &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation III (aerobic) (via p-cresol)</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.44</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7737" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXOADIPATE__45__ENOL__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R8__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gallate degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="CPD__45__19" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__20" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5410" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yghZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-glyceraldehyde 3-phosphate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLYCERALDEHYDE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8339" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DVU_0173 ) or ( phsB and phsA and phsC ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( thiosulfate reductase &amp;gamma; subunit and thiosulfate reductase &amp;beta; subunit and thiosulfate reductase &amp;alpha; subunit ) or ( NA ) or ( thiosulfate reductase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of tetrathionate reduction (Salmonella typhimurium)</html:p>
<html:p>SUBSYSTEM: thiosulfate disproportionation II (non thiol-dependent)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="1"/>
      <speciesReference species="E__45__" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8334" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: esculetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8095" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8096" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8336" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: esculetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.2.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CAFFEATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8098" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5413" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pgaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetyl-D-glucosamine &amp;beta;-1,6-N-acetyl-D-glucosaminyl transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1191" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1192" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5414" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pgaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( poly-&amp;beta;-1,6-N-acetyl-D-glucosamine N-deacetylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1192" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1193" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9476" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cyc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: geosmin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10160" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10158" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8340" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cnx2 ) or ( Cnx3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: molybdenum cofactor biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRECURSOR__45__Z" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9475" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cyc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: geosmin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACETONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10159" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETONE" stoichiometry="1"/>
      <speciesReference species="CPD__45__10160" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9474" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cyc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: geosmin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10159" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8343" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DES6 ) or ( des6 ) or ( desD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;Delta;6-acyl-lipid desaturase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-linolenate biosynthesis I (plants)</html:p>
<html:p>SUBSYSTEM: arachidonate and eicosapentaenoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.19.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Linoleoyl__45__groups__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Gamma__45__linolenoyl__45__groups__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7241" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.26</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6741" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9472" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: Fe(II)-NA phloem transport</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD__45__463</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__463" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10157" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9471" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSTREPTOMYCIN__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__529" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7243" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__534" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6742" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9470" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__14__45__ALPHA__45__L__45__DIHYDROSTREPTOSYL__45__STREPTID" stoichiometry="1"/>
      <speciesReference species="CPD__45__10137" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
      <speciesReference species="DIHYDROSTREPTOMYCIN__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7242" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6741" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6742" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8324" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-6 fatty acid desaturase, endoplasmic reticulum )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8092" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8093" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8325" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-3 fatty acid desaturase monomer )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8093" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__183__45__2__45__183__45__SN__45__GLYCEROL__45__PHOSPHOCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8322" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-6 fatty acid desaturase, endoplasmic reticulum )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2182" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8323" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-3 fatty acid desaturase monomer )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2182" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8090" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8328" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-6 fatty acid desaturase, endoplasmic reticulum )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8088" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2182" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7246" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation II</html:p>
<html:p>SUBSYSTEM: phytate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6747" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6746" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8329" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-3 fatty acid desaturase monomer )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2182" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8093" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7245" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6744" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6747" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8326" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-3 fatty acid desaturase monomer )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8092" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7244" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6744" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8327" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-6 fatty acid desaturase, endoplasmic reticulum )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2181" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8091" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine carbamoyltransferase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: CARBAMOYL__45__P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( spuC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( polyamine aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: putrescine degradation V</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.29</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lathyrine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__4__45__CARBOXYPYRIMIDINE" stoichiometry="1"/>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LATHYRINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__51__45__RXN" name="3-hydroxy-2-methylpyridine-4,5-dicarboxylate 4-decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vitamin B6 degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.51</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__234" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1071" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-D-galacturonate pyrophosphorylase )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-galacturonate biosynthesis II (from D-galacturonate)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="CPD__45__501" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__D__45__GALACTURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MAOB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monoamine oxidase B subunit )</html:p>
<html:p>SUBSYSTEM: putrescine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__30" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__21__46__6__45__RXN" name="Lathosterol oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC5DL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lathosterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.6</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( vanB and vanA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( vanillate O-demethylase B subunit and vanillate O-demethylase A subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.82</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VANILLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__90__45__RXN" name="Diphosphate--fructose-6-phosphate 1-phosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructokinase &amp;beta; subunit and 6-phosphofructokinase &amp;alpha; subunit ) or ( 6-phosphofructokinase &amp;alpha; subunit and 6-phosphofructokinase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: glycolysis IV (plant cytosol)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.90</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( g-cam )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( camphene synthase )</html:p>
<html:p>SUBSYSTEM: oleoresin monoterpene volatiles biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4921" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__0" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: putrescine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7253" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6746" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8332" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: esculetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8098" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8094" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCC__45__FUM__45__OXRED__45__RXN" name="Succinate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( sdhA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle II</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle I</html:p>
<html:p>SUBSYSTEM: incomplete reductive TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7250" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation II</html:p>
<html:p>SUBSYSTEM: phytate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6745" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6747" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8331" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-3 fatty acid desaturase monomer )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8090" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__183__45__2__45__183__45__SN__45__GLYCEROL__45__PHOSPHOCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8330" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-6 fatty acid desaturase, endoplasmic reticulum )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8089" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8090" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DICHCYCLO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,6-DiCH chlorohydrolase )</html:p>
<html:p>SUBSYSTEM: pentachlorophenol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_26__45__DICHLORO__45__P__45__HYDROQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="_6__45__CHQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8311" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8084" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5433" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yfaU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-keto-3-deoxy-L-rhamnonate aldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEHYDRO__45__3__45__DEOXY__45__L__45__RHAMNONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Lactaldehydes__124__" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8313" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8082" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8083" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8314" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8083" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8315" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: sulfate reduction IV (dissimilatory)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HSO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8316" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2183" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8086" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8317" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8086" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8087" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_325__45__BISPHOSPHATE__45__NUCLEOTIDASE__45__RXN" name="3&apos;(2&apos;),5&apos;-bisphosphate nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cysQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine-3&apos;(2&apos;),5&apos;-bisphosphate nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__5__45__ADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8318" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fad4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8086" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2185" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__130" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG11 ) or ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 51 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8319" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fad4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8087" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5123" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS03 ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (E)-&amp;beta;-ocimene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: monoterpene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4903" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5122" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myrcene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4901" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTARYL__45__COA__45__DEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gcdH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5121" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myrcene synthase )</html:p>
<html:p>SUBSYSTEM: oleoresin monoterpene volatiles biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4902" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-3 fatty acid desaturase monomer )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8088" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8089" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8320" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-6 fatty acid desaturase, endoplasmic reticulum )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2181" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8088" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8306" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2189" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8080" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__20__45__RXN" name="4-hydroxybenzoyl-CoA reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hcrA and hcrB and hcrC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybenzoyl-CoA reductase, &amp;gamma; subunit and 4-hydroxybenzoyl-CoA reductase, &amp;beta; subunit and 4-hydroxybenzoyl-CoA reductase, &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: 4-ethylphenol degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.20</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__201" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8307" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fad5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8074" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8076" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fad5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8073" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8075" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8075" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2189" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8302" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2188" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8077" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOSE6P__45__HYDROXY__45__RXN" name="6-phospho-&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lacG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lactose and galactose degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.85</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__1241" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8077" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8079" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8300" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8079" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8080" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8301" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8080" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5111" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: phaseollin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4402" stoichiometry="1"/>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4885" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__127" name="Saccharopine dehydrogenase (NADP+, L-glutamate forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( saccharopine dehydrogenase (NADP+, L-glutamate-forming) )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.10</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5110" name="Myrcene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Lim ) or ( TPS-Car ) or ( f-&amp;gamma;hum ) or ( TPS-Lin ) or ( TPS-Pin ) or ( TPS-Cin ) or ( TPS03 ) or ( TPS-Myr ) or ( TPS10 ) or ( f-&amp;delta;sel1 ) or ( g-myr ) or ( MTS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( limonene synthase ) or ( 3-carene synthase ) or ( &amp;gamma;-humulene synthase ) or ( linalool synthase ) or ( pinene synthase ) or ( 1,8-cineole synthase ) or ( (E)-&amp;beta;-ocimene synthase ) or ( myrcene synthase ) or ( myrcene synthase ) or ( &amp;delta;-selinene synthase ) or ( myrcene synthase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: oleoresin monoterpene volatiles biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>SUBSYSTEM: monoterpene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.15</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4888" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ndk ) or ( NME2 and NME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ndk ) or ( nucleoside diphosphate kinase B and nucleoside diphosphate kinase A )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HAONITRO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cyp ) or ( cyp ) or (  ) or (  ) or ( hao )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P460 monomer ) or ( Cytochrome P460 monomer ) or ( hydroxylamine oxidoreductase subunit ) or ( NA ) or ( hydroxylamine oxidoreductase subunit )</html:p>
<html:p>SUBSYSTEM: ammonia oxidation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="E__45__" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYRIBOSE__45__P__45__ALD__45__RXN" name="Deoxyribose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( deoC ) or ( deoC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleosides degradation</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8076" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8078" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8309" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8078" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINE__45__NUCLEOSIDASE__45__RXN" name="Adenosylhomocysteine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mtn ) or ( mtn ) or ( mtn )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MTA/SAH nucleosidase ) or ( 5&apos;-methylthioadenosine/S-adenosylhomocysteine nucleosidase monomer ) or ( MTA/SAH nucleosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__564" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8310" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8082" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8084" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETATEKIN__45__RXN" name="Acetate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ack ) or ( ackA ) or ( ackA ) or ( purT ) or (  ) or (  ) or ( ackA ) or (  ) or (  ) or (  ) or ( ackB ) or (  ) or ( ack ) or ( ackA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ack ) or ( NA ) or ( NA ) or ( GAR transformylase 2 ) or ( NA ) or ( NA ) or ( AckA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( acetate kinase ) or ( Ack ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate VII</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: acetate formation from acetyl-CoA I</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate II</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate and lactate I</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: acetylene degradation</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate IV</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: pyruvate oxidation pathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: methanogenesis from acetate</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate I</html:p>
<html:p>SUBSYSTEM: gallate degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of acetate utilization and formation</html:p>
<html:p>SUBSYSTEM: L-alanine fermentation to propionate and acetate</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5109" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum ) or ( TPS-Lin ) or ( TPS-Cin ) or ( TPS03 ) or ( TPS10 ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase ) or ( linalool synthase ) or ( 1,8-cineole synthase ) or ( (E)-&amp;beta;-ocimene synthase ) or ( myrcene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: monoterpene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4889" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5108" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Car ) or ( f-&amp;gamma;hum ) or ( TPS-Lin ) or ( TPS-Cin ) or ( g-teo ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-carene synthase ) or ( &amp;gamma;-humulene synthase ) or ( linalool synthase ) or ( 1,8-cineole synthase ) or ( terpinolene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: monoterpene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4890" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5107" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( g-pin2 ) or ( g-&amp;beta;phe ) or ( TPS-Lim ) or ( TPS-Pin ) or ( TPS-Cin ) or ( g-teo ) or ( g-pin1 ) or ( g-lim1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( limonene/&amp;alpha;-pinene synthase ) or ( &amp;beta;-phellandrene synthase ) or ( limonene synthase ) or ( pinene synthase ) or ( 1,8-cineole synthase ) or ( terpinolene synthase ) or ( pinene synthase ) or ( limonene synthase )</html:p>
<html:p>SUBSYSTEM: oleoresin monoterpene volatiles biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>SUBSYSTEM: monoterpene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.14</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4891" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5455" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( puuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-glutamyl-&amp;gamma;-aminobutyraldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYPROPANAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYGUANPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DeoD )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYGUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Cin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,8-cineole synthase )</html:p>
<html:p>SUBSYSTEM: monoterpene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4887" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4261" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__117" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-6 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINOL__45__30" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5101" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Cin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,8-cineole synthase )</html:p>
<html:p>SUBSYSTEM: monoterpene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4887" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5106" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( g-pin2 ) or ( g-&amp;beta;phe ) or ( TPS-Lim ) or ( TPS-Car ) or ( TPS-Pin ) or ( TPS-Cin ) or ( g-teo ) or ( g-pin1 ) or ( g-cam ) or ( g-lim1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( limonene/&amp;alpha;-pinene synthase ) or ( &amp;beta;-phellandrene synthase ) or ( limonene synthase ) or ( 3-carene synthase ) or ( pinene synthase ) or ( 1,8-cineole synthase ) or ( terpinolene synthase ) or ( pinene synthase ) or ( camphene synthase ) or ( limonene synthase )</html:p>
<html:p>SUBSYSTEM: oleoresin monoterpene volatiles biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>SUBSYSTEM: monoterpene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.14</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4892" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTEINE__45__DIOXYGENASE__45__RXN" name="Cysteine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cdo1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>SUBSYSTEM: taurine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.20</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5105" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Cin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,8-cineole synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4894" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5103" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( g-pin2 ) or ( TPS-Car ) or ( TPS-Cin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( limonene/&amp;alpha;-pinene synthase ) or ( 3-carene synthase ) or ( 1,8-cineole synthase )</html:p>
<html:p>SUBSYSTEM: monoterpene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4893" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7282" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6761" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXOPENTENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYINOPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DeoD )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYINOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5460" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lsrG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Autoinducer 2-degrading protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10551" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1317" stoichiometry="1"/>
      <speciesReference species="CPD__45__67" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MCHMBARK__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mch )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mch )</html:p>
<html:p>SUBSYSTEM: methyl-coenzyme M oxidation to CO2</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__11" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__22" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NAD__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( maeA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate dehydrogenase, NAD-requiring )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.38</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9421" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;epsilon;-lactone hydrolase )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.83</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10064" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10065" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC1 ) or ( PDC5 ) or (  ) or ( PDC6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate decarboxylase 1 subunit ) or ( pyruvate decarboxylase 2 subunit ) or ( pyruvate decarboxylase ) or ( pyruvate decarboxylase 3 subunit )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to ethanol II</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate VIII</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9420" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10042" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10064" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__220__45__RXN" name="6-pyruvoyltetrahydropterin 2&apos;-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.220</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__LACTOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNTRANSAM__45__RXN" name="Acetylornithine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( argD ) or ( aruC ) or ( astC ) or ( argD ) or ( ARG8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( succinylornithine transaminase subunit ) or ( AstC ) or ( ArgD ) or ( acetylornithine aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.11</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__469" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9419" name="carvone reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.25</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10037" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10042" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PPPGPPHYDRO__45__RXN" name="Guanosine-5&apos;-triphosphate,3&apos;-diphosphate pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gpp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gpp )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.40</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__TP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE__45__5DP__45__3DP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9413" name="Limonene-1,2-epoxide hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( limA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (-)-(4S)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.8</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4S__45__limonene__45__1__45__2__45__epoxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10055" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9414" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__Hydroxy__45__2__45__oxolimonenes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Isopropenyl__45__4H__45__hexano__45__lactones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREOSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>SUBSYSTEM: aminopropanol biosynthesis</html:p>
<html:p>SUBSYSTEM: aminopropanol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9411" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( limC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carveol dehydrogenase monomer )</html:p>
<html:p>SUBSYSTEM: (-)-(4S)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10055" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10058" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9417" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: (+)-(4R)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10059" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10053" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLALANINE__45__AMMONIA__45__LYASE__45__RXN" name="Phenylalanine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAL1 ) or ( PAL2 ) or (  ) or ( PAL3 ) or ( AT3g10340 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylalanine ammonia lyase ) or ( NA ) or ( phenylalanine ammonia lyase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis, initial reactions</html:p>
<html:p>SUBSYSTEM: salicylate biosynthesis</html:p>
<html:p>SUBSYSTEM: ephedrine biosynthesis</html:p>
<html:p>SUBSYSTEM: suberin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.24</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__674" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__13__46__11__46__9__45__RXN" name="2,5-dihydroxypyridine 5,6-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,5-dihydroxypyridine oxygenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__5__45__DIHYDROXYPYRIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALEAMATE" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9418" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: (-)-(4S)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10060" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10063" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9415" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: (+)-(4R)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10057" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10059" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9416" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: (-)-(4S)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10058" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10060" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__CYCLODEAMINASE__45__RXN" name="Ornithine cyclodeaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( arcB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ornithine cyclodeaminase subunit )</html:p>
<html:p>SUBSYSTEM: ornithine degradation (proline biosynthesis)</html:p>
<html:p>SUBSYSTEM: arginine degradation VII (arginase 3 pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSACETYLGLUCOSAMINEMUT__45__RXN" name="Phosphoacetylglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PGM3 ) or ( PCM1 ) or ( AGM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9410" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( limC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carveol dehydrogenase monomer )</html:p>
<html:p>SUBSYSTEM: (+)-(4R)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8222" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10057" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCTP__45__DEAM__45__RXN" name="dCTP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dcd )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.13</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( ATS1 ) or ( plsB ) or ( AT4G00400 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate acyltransferase ) or ( glycerol-3-phosphate O-acyltransferase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.15</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9409" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (-)-(4S)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4886" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__4S__45__limonene__45__1__45__2__45__epoxides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCDEHYDRAT__45__RXN" name="dTDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rffG ) or ( rfbB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-glucose 4,6-dehydratase 2 ) or ( RmlB )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.46</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9400" name="Carveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( limC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carveol dehydrogenase monomer )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10051" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1089" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9401" name="Carveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( limC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carveol dehydrogenase monomer )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10052" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10037" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4803" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: capsidiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4663" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4661" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4804" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: capsidiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4662" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4661" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9403" name="carvone reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.25</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1089" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10039" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4801" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: capsidiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4664" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4663" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9404" name="Carveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( limC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carveol dehydrogenase monomer )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10050" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1089" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COENZYME__45__F420__45__HYDROGENASE__45__RXN" name="Coenzyme F420 hydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( frhG and frhA and frhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( factor F420-reducing hydrogenase &amp;beta; subunit and factor F420-reducing hydrogenase &amp;alpha; subunit and factor F420-reducing hydrogenase &amp;gamma; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.12.98.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OX__45__COENZYME__45__F420" stoichiometry="1"/>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RED__45__COENZYME__45__F420" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4802" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: capsidiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4664" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9405" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10047" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10053" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAHPSYN__45__RXN" name="2-dehydro-3-deoxyphosphoheptonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aroH ) or ( aroA ) or ( aroF ) or ( aroG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AroH ) or ( AroA ) or ( AroF ) or ( AroG )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.54</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEOXY__45__D__45__ARABINO__45__HEPTULOSONATE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9406" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>SUBSYSTEM: (+)-(4R)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10053" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10054" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9407" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (+)-(4R)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8785" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__4R__45__Limonene__45__1__45__2__45__epoxides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosephosphate isomerase 1 ) or ( glucosephosphate isomerase 2 ) or ( glucose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEH__45__RXN" name="Malate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MDH2 ) or ( MDH1 ) or ( mdh ) or ( MDH1 ) or (  ) or ( mdh ) or ( MDH1 ) or (  ) or (  ) or ( mdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mitochondrial malate dehydrogenase ) or ( malate dehydrogenase, cytoplasmic ) or ( Mdh ) or ( malate dehydrogenase subunit ) or ( NA ) or ( NA ) or ( malate dehydrogenase subunit ) or ( NA ) or ( malate dehydrogenase subunit ) or ( malate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: aspartate degradation II</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle II</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VIII (to propionate)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: incomplete reductive TCA cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.37</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIMSYN1__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( thiC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamin biosynthesis protein ThiC )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R525__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mcrB and mcrA and mcrG ) or ( camC ) or ( acsD and acsC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta; subunit and &amp;alpha; subunit and &amp;gamma; subunit ) or ( cytochrome P-450cam ) or ( corrinoid/iron-sulfur protein &amp;alpha; subunit and corrinoid/iron-sulfur protein &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__842" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="CPD__45__843" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOMEVALONATE__45__KINASE__45__RXN" name="Phosphomevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( erg8 ) or ( PMVK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( phosphomevalonate kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SMT1 ) or ( SMT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol methyltransferase ) or ( sterol methyltransferase )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.41</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYCLOARTENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__696" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AGMATINE__45__DEIMINASE__45__RXN" name="Agmatine deiminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At5g08170 ) or ( aguA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( agmatine iminohydrolase ) or ( agmatine deiminase subunit )</html:p>
<html:p>SUBSYSTEM: arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.12</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AGMATHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__597" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUC4NACTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rffT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: TDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C55__45__PP__45__GLCNAC__45__MANNACA" stoichiometry="1"/>
      <speciesReference species="TDP__45__FUC4NAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
      <speciesReference species="C55__45__PP__45__GLCNAC__45__MANNACA__45__FUC4NAC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONATE__45__5__45__DEHYDROGENASE__45__RXN" name="Gluconate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( idnO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-keto-D-gluconate 5-reductase )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>SUBSYSTEM: L-idonate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.69</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__DEHYDROGLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__73__45__RXN" name="Tabersonine 16-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP71D12 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: vindoline and vinblastine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.73</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TABERSONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_16__45__HYDROXYTABERSONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1__45__42" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( phbC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( poly-&amp;beta;-hydroxybutyrate polymerase subunit )</html:p>
<html:p>SUBSYSTEM: polyhydroxybutyrate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CPD__45__650</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
      <speciesReference species="PHB" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHB" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( folC ) or ( folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpoly-&amp;gamma;-synthetase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Folatepolyglutamate__45__n__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD_TO_NADH_COF_RXN" name="NAD_TO_NADH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__NORLAUDANOSOLINE__45__SYNTHASE__45__RXN" name="(S)-norcoclaurine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NCS1 ) or ( AY376412 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( norcoclaurine synthase )</html:p>
<html:p>SUBSYSTEM: (S)-reticuline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.78</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
      <speciesReference species="HYDRPHENYLAC__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__NORCOCLAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHENYLTHFCYCLOHYDRO__45__RXN" name="Methenyltetrahydrofolate cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AF030516 ) or ( folD ) or ( folD ) or (  ) or ( fchA ) or ( MTHFD1 ) or ( folD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methenylTHF cyclohydrolase/methyleneTHF dehydrogenase subunit ) or ( CYC subunits ) or ( NA ) or ( FolD ) or ( NA ) or ( folate cyclohydrolase subunit ) or ( MTHFD monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: reductive acetyl coenzyme A pathway</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__PHOSPHOGLUCOMUTASE__45__RXN" name="&amp;beta;-phosphoglucomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( pgmB ) or ( ycjU ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-phosphoglucomutase ) or ( NA ) or ( &amp;beta;-phosphoglucomutase ) or ( NA ) or ( &amp;beta;-phosphoglucomutase )</html:p>
<html:p>SUBSYSTEM: trehalose degradation III</html:p>
<html:p>SUBSYSTEM: trehalose degradation IV</html:p>
<html:p>SUBSYSTEM: maltose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__448" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRYL__45__COA__45__HYDROLASE__45__RXN" name="3-hydroxyisobutyryl-CoA hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hibch )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TDPFUCACTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rffC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP__45__D__45__FUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP__45__FUC4NAC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERSYN__45__RXN" name="CDP-diacylglycerol--serine O-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TaPSS1 ) or ( LOC_Os01g66900.1 ) or ( pssA ) or ( LOC_Os04g41810.1 ) or ( PTDSS1 ) or ( LOC_Os01g67010.1 ) or ( AT1G15110 ) or ( LOC_Os01g49024.1 ) or ( LOC_Os01g67030.1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine synthase ) or ( dopamine beta-monooxygenase, putative, expressed ) or ( PssA ) or ( dopamine beta-monooxygenase, putative, expressed ) or ( phosphatidylserine synthase I ) or ( expressed protein ) or ( CDP-diacylglycerol-serine O-phosphatidyltransferase ) or ( phosphatidyl serine synthase family protein, expressed ) or ( dopamine beta-monooxygenase, putative, expressed )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylethanolamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.8</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIOPTERIN_TO_TETRA__45__H__45__BIOPTERIN_COF_RXN" name="BIOPTERIN_TO_TETRA-H-BIOPTERIN_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AtXT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-xylosyltransferase ) or ( &amp;alpha;-xylosyltransferase )</html:p>
<html:p>SUBSYSTEM: xyloglucan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__D__45__XYLOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="3"/>
      <speciesReference species="__124__1__45__4__45__beta__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Xyloglucans__45__Xylose__124__" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="3"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETRAHYDROBERBERINE__45__OXIDASE__45__RXN" name="Tetrahydroberberine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( (S)-tetrahydroprotoberberine oxidase )</html:p>
<html:p>SUBSYSTEM: berberine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.8</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__TETRAHYDROBERBERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BERBERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9464" name="Limonene-1,2-epoxide hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( limA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10139" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA_TO_CO__45__A_COF_RXN" name="MALONYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MUR3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xyloglucan galactosyltransferase )</html:p>
<html:p>SUBSYSTEM: xyloglucan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Xyloglucans__45__Xylose__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Xyloglucans__45__Galactose__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__88__45__RXN" name="Peptide deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( def )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptide deformylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.88</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9463" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtFUT1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-1,2-fucosyltransferase ) or ( &amp;alpha;-1,2-fucosyltransferase )</html:p>
<html:p>SUBSYSTEM: xyloglucan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__L__45__GALACTOSE</html:p>
<html:p>SIDE: GUANOSINE_DIPHOSPHATE_FUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Xyloglucans__45__Galactose__124__" stoichiometry="1"/>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
      <speciesReference species="GDP__45__L__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="2"/>
      <speciesReference species="__124__Xyloglucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__1__46__5__45__RXN" name="2-oxopropyl-CoM reductase (carboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xecC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-oxopropyl-CoM reductase subunit )</html:p>
<html:p>SUBSYSTEM: propylene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__CoM__124__</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOPROPYL__45__COM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__CoM__124__" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9457" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Rv3377c )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tuberculosinol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10116" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__HYDROXYHEXANOATE__45__OXIDATION__45__RXN" name="6-hydroxyhexanoate oxidation" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( chnD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cyclohexanol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.258</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__102" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__OXO__45__HEXANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9456" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cyc1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: terpentecin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10113" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__KIN__45__RXN" name="Glycerol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glpK2 ) or ( glpK ) or ( glpK1 ) or ( At1g80460 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol kinase 2 ) or ( GlpK ) or ( glycerol kinase 1 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.30</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9455" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cyc2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( terpentetriene synthase monomer )</html:p>
<html:p>SUBSYSTEM: terpentecin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.36</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10113" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10114" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ilvG_1 and ilvG_2 and ilvM ) or ( ilvN and ilvB ) or ( ilvH and ilvI ) or ( als ) or ( ilvB and ilvN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IlvM and acetolactate synthase II, large subunit, C-ter fragment (pseudogene) and acetolactate synthase II, large subunit, N-ter fragment (pseudogene) ) or ( IlvN and IlvB ) or ( IlvH and IlvI ) or ( &amp;alpha;-acetolactate synthase subunit ) or ( acetohydroxy-acid synthase large subunit and acetohydroxy-acid synthase small subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis I</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9459" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Rv3378c )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tuberculosinol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10116" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10117" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LTARTDEHYDRA__45__RXN" name="L(+)-tartrate dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ttdA and ttdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-tartrate dehydratase, &amp;beta; subunit and L-tartrate dehydratase, &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.32</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HMM6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pisatin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3942" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3944" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__UREIDOPROPIONASE__45__RXN" name="&amp;beta;-ureidopropionase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PYD3 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-ureidopropionase ) or ( &amp;beta;-ureidopropionase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R343__45__RXN" name="Cob(II)yrinic acid a,c-diamide reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fldA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavodoxin A ) or ( cob(II)yrinate a,c-diamide reductase subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 1.16.8.1</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FMN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__689" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__694" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOINASE__45__RXN" name="Allantoinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( allB ) or ( AtALN ) or (  ) or ( RpALN ) or ( DAL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allantoinase monomer ) or ( NA ) or ( allantoinase ) or ( NA ) or ( allantoinase )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation in plants</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate I (urea producing)</html:p>
<html:p>SUBSYSTEM: allantoin degradation IV (anaerobic)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate II (ammonia producing)</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation in yeast</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate III</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate I</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.5</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ALLANTOIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9452" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dmpM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: puromycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.38</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10088" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10091" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9453" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( napH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: puromycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="PUROMYCIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1346" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 13-LOX and 13-HPL pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__3__45__HEXENAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__2__45__HEXENAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINE__45__6__45__P__45__DEAMIN__45__RXN" name="Glucosamine-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nagB ) or ( GPI1 ) or ( nagB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine-6-phosphate deaminase subunit ) or ( glucosamine 6-phosphate isomerase 1 ) or ( NagB )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9444" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pur10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: puromycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10076" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1345" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( HPL1 )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 13-LOX and 13-HPL pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__725" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__3__45__HEXENAL" stoichiometry="1"/>
      <speciesReference species="_12__45__OXO__45__CIS__45__9__45__DODECENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9447" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pur3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: puromycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10079" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10101" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8399" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>SIDE: OH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH" stoichiometry="1"/>
      <speciesReference species="CPD__45__8213" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBONYL__45__SULFIDE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9446" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pur7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: puromycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10100" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10079" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9449" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pac )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: puromycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10080" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10082" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9448" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pur6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: puromycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: TYR</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="CPD__45__10101" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10080" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__OXIDASEII__45__RXN" name="Choline oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( codA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline oxidase subunit )</html:p>
<html:p>SUBSYSTEM: choline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.17</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URUR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( allC ) or ( AtAAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allantoate amidohydrolase ) or ( allantoate amidohydrolase monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation in plants</html:p>
<html:p>SUBSYSTEM: allantoin degradation IV (anaerobic)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate II (ammonia producing)</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate III</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__598" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__4__46__27__45__RXN" name="Methenyltetrahydromethanopterin cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mch ) or ( mch ) or ( mch )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mch ) or ( methenyltetrahydropterin cyclohydrolase subunit ) or ( Mch )</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation VI (H4MPT pathway)</html:p>
<html:p>SUBSYSTEM: methanogenesis from CO2</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.27</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHENYLTETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THMPT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOADEHYDROG__45__RXN" name="Acyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fadE ) or ( aidB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( AidB )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STRICTOSIDINE__45__SYNTHASE__45__RXN" name="Strictosidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.3.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
      <speciesReference species="SECOLOGANIN__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="STRICTOSIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXINE__45__4__45__OXIDASE__45__RXN" name="Pyridoxine 4-oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pno )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vitamin B6 degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.12</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCPDIESTER__45__RXN" name="Glycerophosphodiester phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ugpQ ) or ( glpQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerophosphodiester phosphodiesterase, cytosolic ) or ( GlpQ )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.46</html:p>
<html:p>SIDE: __124__Alcohols__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycerophosphodiesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTODEHYDROG__45__RXN" name="D-galactose 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gal ) or (  ) or (  ) or ( gal ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( D-galactose dehydrogenase subunit ) or ( D-galactose dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: galactose degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.48</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GALACTONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHMS__45__DEHYDROGENASE__45__RXN" name="5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hpaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of 5-carboxymethyl-2-hydroxymuconic semialdehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.60</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__783" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__784" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETYL__45__COA__45__TRANSFER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( atoD and atoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA:acetoacetyl-CoA transferase, &amp;alpha; subunit and acetyl-CoA:acetoacetyl-CoA transferase, &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: acetoacetate degradation (to acetyl CoA)</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9442" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10102" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9443" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;epsilon;-lactone hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.83</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__6__45__isopropenyl__45__3__45__methyloxepan__45__2__45__one__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__H__45__5__45__I__45__2__45__methylhexanoates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8398" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="CPD__45__8213" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__844" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9440" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Menthones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__7__45__isopropyl__45__4__45__methyloxepan__45__2__45__ones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8397" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8213" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9441" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1909" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8392" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD2-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dimorphecolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8203" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6142" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5804" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ANTHRANSYN__45__RXN" name="Anthranilate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AANTSYNA ) or ( trpGD and trpE ) or ( AANTSYNB ) or ( trpE and trpG ) or ( trpD and trpE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( anthranilate synthase component II and anthranilate synthase component I ) or ( NA ) or ( anthranilate synthase &amp;beta; subunit and anthranilate synthase &amp;alpha; subunit ) or ( anthranilate synthase component I and anthranilate synthase component II )</html:p>
<html:p>SUBSYSTEM: acridone alkaloid biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.27</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8393" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD2-2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dimorphecolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8203" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8204" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9436" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;epsilon;-lactone hydrolase )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.83</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10068" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10071" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9435" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10040" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10068" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9434" name="dihydrocarveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+-dependent dihydrocarveol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.296</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10031" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10040" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9433" name="dihydrocarveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+-dependent dihydrocarveol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.296</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10029" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10040" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRS__45__RXN" name="phosphoribosylformylglycinamidine cyclo-ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( purM ) or ( ade5,7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PurM ) or ( Ade5,7 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTARDEHYDRA__45__RXN" name="Galactarate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( garD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.42</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__KETO__45__4__45__DEOXY__45__D__45__GLUCARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45____45__COA__45__LIGASE__45__RXN" name="Malate--CoA ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mtkA and mtkB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate thiokinase &amp;beta; subunit and malate thiokinase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: ethylmalonyl pathway</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__208" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8387" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: linear furonocoumarin biosynthesis II</html:p>
<html:p>SUBSYSTEM: linear furanocoumarin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOALEXIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BERGAPTOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9430" name="dihydrocarveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+-dependent dihydrocarveol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.296</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10034" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10041" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8386" name="Psoralen synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: linear furanocoumarin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.102</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ACETONE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8191" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTOALEXIN__45__CMPD" stoichiometry="1"/>
      <speciesReference species="ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9431" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10069" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__25__45__RXN" name="Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylL ) or ( benD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: benzoate degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation IV (aerobic) (via catechol)</html:p>
<html:p>SUBSYSTEM: meta cleavage pathway of aromatic compounds</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.25</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__290" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9432" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;epsilon;-lactone hydrolase )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.83</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10069" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10072" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ilvE ) or ( tyrB ) or ( ilvE ) or ( ilvE ) or ( BAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase subunit ) or ( TyrB ) or ( IlvE ) or ( branched-chain-amino-acid aminotransferase subunit ) or ( branched-chain amino acid aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8383" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: linear furanocoumarin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8192" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8191" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: linear furanocoumarin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__8186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8192" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8380" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: sulfur reduction II (via polysulfide)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CPD__45__846</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S8" stoichiometry="1"/>
      <speciesReference species="CPD__45__846" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Polysulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9427" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10039" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10040" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9426" name="dihydrocarveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+-dependent dihydrocarveol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.296</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10032" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10042" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4823" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sesquiterpenoid phytoalexins biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.21</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4703" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9429" name="dihydrocarveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+-dependent dihydrocarveol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.296</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10026" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10041" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4822" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( patA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__L__45__2__45__AMINO__45__6__45__OXO__45__PIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1771" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9428" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10042" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10041" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4821" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__AMINO__45__EPSILON__45__KETO__45__PIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3701" name="Protein geranylgeranyltransferase type I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GGB and FTA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyltransferase &amp;alpha;-subunit/geranylgeranyltransferase Type I &amp;alpha; subunit and geranylgeranyltransferase Type I &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.59</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__GERANYLGERANYL__45__PROTEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9423" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>SUBSYSTEM: (-)-(4S)-limonene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__10063" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10066" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8379" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PcFSI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavone synthase I )</html:p>
<html:p>SUBSYSTEM: chrysin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.22</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6991" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8184" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__87__45__RXN" name="Homoisocitrate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS12 ) or ( hicdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homo-isocitrate dehydrogenase ) or ( homoisocitrate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.87</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__I__45__CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9422" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10065" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10063" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9425" name="dihydrocarveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+-dependent dihydrocarveol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: (4S)-carveol and (4S)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.296</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10033" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10042" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9424" name="dihydrocarveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+-dependent dihydrocarveol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.296</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10027" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10039" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMUR__45__ALA__45__LIG__45__RXN" name="UDP-N-acetylmuramate--alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( murC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__ACETYLMURAMOYL__45__ALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANOSINE__45__DIPHOSPHATASE__45__RXN" name="Guanosine-diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nudJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.42</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__7__46__1__46__8__45__RXN" name="2,6-dioxo-6-phenylhexa-3-enoate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bphD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase )</html:p>
<html:p>SUBSYSTEM: biphenyl degradation</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__613" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXOPENTENOATE" stoichiometry="1"/>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__PYRIDOXOLACTONASE__45__RXN" name="4-pyridoxolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlr6805 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-pyridoxolactonase subunit )</html:p>
<html:p>SUBSYSTEM: vitamin B6 degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.27</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__375" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1112" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLALANINE__45__DECARBOXYLASE__45__RXN" name="Phenylalanine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AADC2 ) or ( AADC1A ) or ( AADC1B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.53</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLETHYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4261" name="isethionate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isethionate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3745" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFOACETALDEHYDE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDEHYDE__45__REDUCTASE__45__NADPH__45__RXN" name="Lactaldehyde reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yqhD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.55</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPANE__45__1__45__2__45__DIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSLIG__45__RXN" name="Phosphopantothenate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dfp ) or ( AtCoaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis III</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BA7DEHYDRA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( baiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of bile acid 7&amp;alpha;-dehydratase )</html:p>
<html:p>SUBSYSTEM: cholate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OXO__45__DELTA4__45__CHOLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXO__45__DELTA46__45__CHOLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__969" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT3G14415 ) or ( AT5G06580 ) or ( AT3G14150 ) or ( AT3G14130 ) or ( AT4G18360 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycolate oxidase ) or ( glycolate oxidase ) or ( glycolate oxidase ) or ( glycolate oxidase ) or ( glycolate oxidase )</html:p>
<html:p>SUBSYSTEM: photorespiration</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTODEG__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( malQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rbcS1A and ATCG00490 ) or ( ATCG00490 and rbcS3B ) or ( ATCG00490 and rbcS2B ) or ( ATCG00490 and rbcS1B ) or ( cbbS and cbbL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( RUBISCO small subunit and RUBISCO large subunit ) or ( RUBISCO small subunit and RUBISCO large subunit ) or ( RUBISCO large subunit and RUBISCO small subunit ) or ( RUBISCO small subunit and RUBISCO large subunit ) or ( CbbL and CbbS )</html:p>
<html:p>SUBSYSTEM: photorespiration</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__RIBULOSE__45__15__45__P2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
      <speciesReference species="CPD__45__67" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__3__45__DEHYDROGENASE__45__RXN" name="Carnitine 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( PP0302 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-carnitine dehydrogenase subunit ) or ( L-carnitine dehydrogenase subunit ) or ( L-carnitine dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-butyrobetaine degradation</html:p>
<html:p>SUBSYSTEM: carnitine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.108</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DE__45__H__45__CARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__3__46__22__45__RXN" name="Proclavaminate amidinohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pah )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proclavaminate amidino hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: clavulanate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMIDINOPROCLAVAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROCLAVAMINATE" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROCANATE__45__HYDRATASE__45__RXN" name="Urocanate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hutU ) or ( hutU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( HutU ) or ( urocanase subunit )</html:p>
<html:p>SUBSYSTEM: histidine degradation I</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>SUBSYSTEM: histidine degradation VI</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.49</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROCANATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__11__46__1__46__12__45__RXN" name="Phospholipid-hydroperoxide glutathione peroxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPX4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione peroxidase 4 )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.12</html:p>
<html:p>SIDE: LIPID</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: A__45__LIPID__45__HYDROPEROXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__LIPID__45__HYDROPEROXIDE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="LIPID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALOSE6PSYN__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalose-phosphate synthase (UDP-forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( otsA ) or ( tps1 ) or ( otsA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.15</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__172" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox1 ) or ( GA2ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__482" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__498" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__171" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox1 ) or ( GA2ox3 ) or ( GA2ox1 ) or ( GA2ox2 ) or ( GA2ox1 ) or ( GA2ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__134" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__482" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXY__45__2__45__KETOPIMELATE__45__LYSIS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hpaI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.-</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__804" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R463__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( trzA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( s-triazine hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__801" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="CPD__45__9368" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CPM__45__KDOSYNTH__45__RXN" name="3-deoxy-manno-octulosonate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CKS ) or ( kdsB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 3-deoxy-D-manno-octulosonate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.38</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="KDO" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__974" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine aminotransferase )</html:p>
<html:p>SUBSYSTEM: photorespiration</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__2__46__1__46__28__45__RXN" name="3-&amp;alpha;,7-&amp;alpha;-dihydroxy-5-&amp;beta;-cholestanate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Slc27a5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bile acid CoA ligase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.28</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__1834" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__72" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYL__45__COM__45__HTP__45__RXN" name="Coenzyme-B sulfoethylthiotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mcrG and mcrB and mcrA ) or ( mcrB and mcrA and mcrG ) or ( mrtA and mrtG and mrtB ) or ( mcrG and mcrB and mcrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta; subunit and &amp;gamma; subunit and &amp;alpha; subunit ) or ( &amp;beta; subunit and &amp;alpha; subunit and &amp;gamma; subunit ) or ( &amp;beta; subunit and &amp;gamma; subunit and &amp;alpha; subunit ) or ( &amp;beta; subunit and &amp;gamma; subunit and &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: methyl-coenzyme M reduction to methane</html:p>
<html:p>PROTEIN_CLASS: 2.8.4.1</html:p>
<html:p>SIDE: CPD__45__1282</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1281" stoichiometry="1"/>
      <speciesReference species="__124__Me__45__CoM__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1282" stoichiometry="1"/>
      <speciesReference species="CH4" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLFORMAMIDASE__45__RXN" name="Arylformamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( kynB ) or (  ) or ( BNA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynurenine formamidase I ) or ( NA ) or ( kynurenine formamidase II ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: tryptophan degradation I (via anthranilate)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__FORMYLKYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAICARSYN__45__RXN" name="Phosphoribosylaminoimidazole-succinocarboxamide synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade1 ) or ( purC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( PurC )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATPPHOSPHORIBOSYLTRANS__45__RXN" name="ATP phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hisG ) or ( AtATP-PRT1 ) or ( hisG ) or ( AtATP-PRT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( HisG ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.17</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__104__45__RXN" name="(+)-menthofuran synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MFS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.104</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4942" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4981" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOLACTOSE__45__RXN" name="&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lactose degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOLACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1242" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TROPINE__45__DEHYDROGENASE__45__RXN" name="Tropine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( TR-I )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tropinone reductase (TR-I) ) or ( NA )</html:p>
<html:p>SUBSYSTEM: hyoscyamine and scopolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.206</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TROPINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TROPINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHIONINE__45__GAMMA__45__LYASE__45__RXN" name="Methionine &amp;gamma;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdeA ) or ( AT1G64660 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MdeA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: methionine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.11</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__7671</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__7671" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R247__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( norA and norB ) or (  ) or ( norA and norB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrite oxidoreductase &amp;beta; subunit and nitrite oxidoreductase &amp;alpha; subunit ) or ( nitrite oxidoreductase 29 kDa subunit and nitrite oxidoreductase 55 kDa subunit and nitrite oxidoreductase 19kDa subunit ) or ( nitrite oxidoreductase &amp;beta; subunit and nitrite oxidoreductase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: nitrite oxidation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRATE" stoichiometry="1"/>
      <speciesReference species="E__45__" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCOSE_TO_UDP_COF_RXN" name="UDP-GLUCOSE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FERRIC__45__CHELATE__45__REDUCTASE__45__RXN" name="Ferric-chelate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( OsFRO1 ) or ( OsFRO2 ) or ( AtFRO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: Fe(III)-reduction and Fe(II) transport</html:p>
<html:p>PROTEIN_CLASS: 1.16.1.7</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FE__43__3" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FE__43__2" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__2__46__41__45__RXN" name="Vanillin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCHL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: capsaicin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.41</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXY__45__ETCETERA__45__HYDROXYPROPIONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="VANILLIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG6PDEACET__45__RXN" name="N-acetylglucosamine-6-phosphate deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nagA ) or ( nagA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine-6-phosphate deacetylase subunit ) or ( NagA )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_13__45__PROPANEDIOL__45__DEHYDROGENASE__45__RXN" name="1,3-propanediol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dhaT ) or ( dhaT ) or ( dhaT ) or ( dhaT ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,3-propanediol dehydrogenasesubunit ) or ( 1,3-propanediol dehydrogenase subunit ) or ( 1,3-propanediol dehydrogenase subunit ) or ( 1,3-propanediol dehydrogenase subunit ) or ( 1,3-propanediol dehydrogenase subunit ) or ( 1,3-propanediol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: glycerol degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.202</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYPROPANAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__347" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPSYNTH__45__RXN" name="Pyruvate,water dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( pps )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( PpsA )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.2</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7985" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VDE1 ) or ( NPQ1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( violaxanthin deepoxidase subunit )</html:p>
<html:p>SUBSYSTEM: antheraxanthin and violaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>SUBSYSTEM: xanthophyll cycle</html:p>
<html:p>PROTEIN_CLASS: 1.10.99.3</html:p>
<html:p>SIDE: L__45__DEHYDRO__45__ASCORBATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ASCORBATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__131" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
      <speciesReference species="CPD1F__45__130" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pVR1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: medicarpin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.246</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3401" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3441" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOKIN__45__RXN" name="Galactokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( galK ) or ( AGK1 ) or ( galK ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( galactokinase )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Galactose__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3602" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: medicarpin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3402" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7982" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ids2 ) or ( ids-2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: hydroxylated mugineic acid phytosiderophore biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.25</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7231" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7289" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7984" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( VDE1 ) or ( NPQ1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( violaxanthin deepoxidase subunit )</html:p>
<html:p>SUBSYSTEM: antheraxanthin and violaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>SUBSYSTEM: xanthophyll cycle</html:p>
<html:p>PROTEIN_CLASS: 1.10.99.3</html:p>
<html:p>SIDE: L__45__DEHYDRO__45__ASCORBATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ASCORBATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
      <speciesReference species="CPD1F__45__133" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
      <speciesReference species="CPD1F__45__131" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPDECARBOX__45__RXN" name="Aspartate 1-decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( panD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PanD &amp;beta; cleavage product and PanD &amp;alpha; cleavage product )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.11</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7983" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ids2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hydroxylated mugineic acid phytosiderophore biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.25</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7227" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7291" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R205__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>SUBSYSTEM: methanofuran biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__149" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R186__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sulfate reduction IV (dissimilatory)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HSO3" stoichiometry="1"/>
      <speciesReference species="CPD__45__552" stoichiometry="1"/>
      <speciesReference species="E__45__" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HSO3" stoichiometry="2"/>
      <speciesReference species="S2O3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__8__45__RXN" name="Saccharopine dehydrogenase (NADP+, L-lysine forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AASS ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-lysine-&amp;alpha;-ketoglutarate reductase subunit ) or ( lysine-ketoglutarate reductase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNP__45__RXN" name="Purine-nucleoside phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NP ) or ( deoD ) or ( deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase subunit ) or ( DeoD ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__DEHYDROPANTOATE__45__REDUCT__45__RXN" name="2-dehydropantoate 2-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( panE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-dehydropantoate 2-reductase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.169</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDROPANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHYLMALEATE__45__HYDRATASE__45__RXN" name="Dimethylmaleate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dmdA and dmdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dimethylmaleate hydratase subunit A and dimethylmaleate hydratase subunit B )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.85</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYLMAL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__61" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7185" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3)</html:p>
<html:p>SUBSYSTEM: superpathway of lipid-dependent phytate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__505" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6661" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MHPELY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylK ) or ( mhpE ) or (  ) or ( cmtG ) or ( dmpG ) or ( todH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( 4-hydroxy-2-oxovalerate aldolase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2-oxopentenoate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation II (aerobic) (via 4-methylcatechol)</html:p>
<html:p>SUBSYSTEM: toluene degradation V (aerobic) (via toluene-cis-diol)</html:p>
<html:p>SUBSYSTEM: toluene degradation IV (aerobic) (via catechol)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>SUBSYSTEM: p-cymene degradation</html:p>
<html:p>SUBSYSTEM: catechol degradation I (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: catechol degradation II (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: toluene degradation I (aerobic) (via o-cresol)</html:p>
<html:p>SUBSYSTEM: p-cumate degradation</html:p>
<html:p>SUBSYSTEM: meta cleavage pathway of aromatic compounds</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXY__45__2__45__KETOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7186" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPK2&amp;alpha; ) or ( IPK2&amp;beta; )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3)</html:p>
<html:p>SUBSYSTEM: superpathway of lipid-dependent phytate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6661" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__991" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox8 ) or ( GA2ox7 ) or ( GA2ox1 ) or ( GA2ox3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__695" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__477" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At3g30775 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( IPK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipid-dependent phytate biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis I (via Ins(1,4,5)P3)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__534" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R162__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kdhA and kdhB and kdhC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( KdhC and KdhB and KdhA )</html:p>
<html:p>SUBSYSTEM: nicotine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__107" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__113" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( At5g62530 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-pyrroline-5-carboxylate dehydrogenase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: proline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7184" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPK2&amp;alpha; ) or ( IPK2&amp;beta; )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3)</html:p>
<html:p>SUBSYSTEM: superpathway of lipid-dependent phytate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7998" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PfAT208 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: pelargonidin conjugates biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: P__45__COUMAROYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PELARGONIDIN__45__3__45__GLUCOSIDE__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7384" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__3__46__34__45__RXN" name="Berbamunine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP80A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: bisbenzylisoquinoline alkaloid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__N__45__METHYLCOCLAURINE" stoichiometry="1"/>
      <speciesReference species="R__45__N__45__METHYLCOCLAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BERBAMUNINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7997" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PfAT208 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvianin biosynthesis</html:p>
<html:p>SUBSYSTEM: pelargonidin conjugates biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CAFFEOYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CAFFEOYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PELARGONIDIN__45__3__45__GLUCOSIDE__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7383" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4229" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DET2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxo-5&amp;alpha;-steroid 4-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3945" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3946" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4226" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SAX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&amp;beta;-hydroxysteroid dehydrogenase/&amp;Delta;5-&amp;Delta;4-isomerase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3943" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3945" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4225" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid 22&amp;alpha;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__707" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3943" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4224" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;24 reductase )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4142" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4143" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4222" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;24 reductase )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__706" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4141" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHS__45__PHOSPHATASE__45__RXN" name="dihydrosphingosine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LCB3 ) or ( YSR3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.91</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4221" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;24 reductase )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4127" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4142" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__99__46__19__45__RXN" name="2-hydroxypropyl-CoM lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xecA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxypropyl-CoM lyase subunit )</html:p>
<html:p>SUBSYSTEM: propylene degradation</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.23</html:p>
<html:p>SIDE: __124__CoM__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__12__45__EPOXYPROPANE" stoichiometry="1"/>
      <speciesReference species="__124__CoM__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__R__45__HYDROXYPROPYL__45__COM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__REDUCTASE__45__RXN" name="Hydroxymethylglutaryl-CoA reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mvaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl-coenzyme A reductase subunit )</html:p>
<html:p>SUBSYSTEM: mevalonate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.88</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__9__45__RXN" name="Glyceraldehyde-3-phosphate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GAPN ) or ( NP-GAPDH ) or ( gapN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent glyceraldehyde-3-phosphate dehydrogenase subunit ) or ( NA ) or ( NADP-dependent glyceraldehyde-3-phosphate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: glycolysis IV (plant cytosol)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.9</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETPYRKIN__45__RXN" name="Hydroxymethylpyrimidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdxK ) or ( thiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PdxK ) or ( NA )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.49</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOSINE__45__NUCLEOSIDASE__45__RXN" name="Inosine nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rihC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleoside hydrolase 3 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hemN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen II</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.22</html:p>
<html:p>SIDE: CH33ADO</html:p>
<html:p>SIDE: MET</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
      <speciesReference species="CH33ADO" stoichiometry="2"/>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__KETOGLUCOSIDASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sucrose degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: FRU</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__384" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="_3__45__DEHYDRO__45__ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3624" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HI4&apos;OMT ) or ( HI4&apos;OMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: pterocarpan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXYISOFLAVANONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3502" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3625" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIDM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: pterocarpan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3502" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMONONETIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4231" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid 22&amp;alpha;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__698" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3945" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7968" name="quinate/shikimate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ydiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.282</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5761" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5601" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__7__46__1__46__9__45__RXN" name="2-hydroxymuconate-semialdehyde hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: catechol degradation I (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation IV (aerobic) (via catechol)</html:p>
<html:p>SUBSYSTEM: catechol degradation to 2-oxopent-4-enoate I</html:p>
<html:p>SUBSYSTEM: meta cleavage pathway of aromatic compounds</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMUCONATE__45__SALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXOPENTENOATE" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4230" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid 22&amp;alpha;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__709" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3946" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7967" name="quinate/shikimate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ydiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.282</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5762" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5601" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5763" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5602" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACCOA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pct )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate II (acrylate pathway)</html:p>
<html:p>SUBSYSTEM: L-alanine fermentation to propionate and acetate</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__LACTOYL__45__COA" stoichiometry="1"/>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_THF_COF_RXN" name="METHYLENE-THF_TO_THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NANE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nanE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( predicted N-acetylmannosamine-6-phosphate epimerase )</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: N-acetylneuraminate and N-acetylmannosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__120__45__RXN" name="12-hydroxydihydrochelirubine 12-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.120</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_12__45__HYDROXYDIHYDROCHELIRUBINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROMACARPINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE_TO_UDP_COF_RXN" name="UDP-GLUCURONATE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__114__45__RXN" name="2-coumarate O-&amp;beta;-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coumarin biosynthesis (via 2-coumarate)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.114</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__COUMARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__459" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DALADEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dadA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-amino acid dehydrogenase, small subunit and D-amino acid dehydrogenase, large subunit )</html:p>
<html:p>SUBSYSTEM: alanine degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ALKYLCYSTEINE__45__LYASE__45__RXN" name="S-alkylcysteine lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lcd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__Alkyl__45__L__45__Cysteines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alkyl__45__Thiols__124__" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4243" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP710A2 ) or ( CYP710A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4143" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4162" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7979" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ABA2 ) or ( ABA1 ) or ( ABA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( zeaxanthin epoxidase ) or ( zeaxanthin epoxidase subunit ) or ( zeaxanthin epoxidase )</html:p>
<html:p>SUBSYSTEM: capsanthin and capsorubin biosynthesis</html:p>
<html:p>SUBSYSTEM: antheraxanthin and violaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>SUBSYSTEM: xanthophyll cycle</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.90</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__131" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__133" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7978" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ABA2 ) or ( ABA1 ) or ( ABA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( zeaxanthin epoxidase ) or ( zeaxanthin epoxidase subunit ) or ( zeaxanthin epoxidase )</html:p>
<html:p>SUBSYSTEM: antheraxanthin and violaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>SUBSYSTEM: xanthophyll cycle</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.90</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__130" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__131" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4241" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BR6ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( brassinosteroid-6-oxidase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__720" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__719" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__47__45__RXN" name="4-trimethylammoniobutyraldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Aldh9a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: L-carnitine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.47</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__TRIMETHYLAMMONIOBUTANAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__BUTYROBETAINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_DIHYDROFOLATE_COF_RXN" name="METHYLENE-THF_TO_DIHYDROFOLATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYBENZOYLFORMATE__45__DECARBOXYLASE__45__RXN" name="Benzoylformate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdlC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MdlC ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.7</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__142" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXYBENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCHTHAUERA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dch )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyclohexa-1,5-diene-1-carboxyl-CoA hydratase subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYCLOHEXA__45__15__45__DIENE__45__1__45__CARBONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__HYDROXYCYCLOHEX__45__1__45__ENE__45__1__45__CARBONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TSMOS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tsaB and tsaM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-toluene-sulfonate monooxygenase reductase subunit and TsaM )</html:p>
<html:p>SUBSYSTEM: 4-toluenesulfonate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__TOLUENESULFONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__SULFOBENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIACYLGLYCEROL__45__LIPASE__45__RXN" name="Triacylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SDP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.3</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="__124__Diacylglycerides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__11__45__RXN" name="UTP--xylose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( USP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__490" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7143" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6644" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8680" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SDH_Pp7 ) or ( SDH_Fi321 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SDH subunit ) or ( SDH subunit )</html:p>
<html:p>SUBSYSTEM: matairesinol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8909" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8911" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6642" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7141" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( CYP81E1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: wighteone and luteone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.89</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6641" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8683" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PLR_Tp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PLR subunit )</html:p>
<html:p>SUBSYSTEM: matairesinol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8906" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8908" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8684" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PLR_Tp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PLR subunit )</html:p>
<html:p>SUBSYSTEM: matairesinol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8908" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8910" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8681" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SDH_Pp7 ) or ( SDH_Fi321 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SDH subunit ) or ( SDH subunit )</html:p>
<html:p>SUBSYSTEM: matairesinol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8911" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8912" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULOKIN__45__RXN" name="L-ribulokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( araB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-ribulokinase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.16</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribulose__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribulose__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7947" name="capsanthin/capsorubin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CCS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( capsanthin-capsorubin synthase )</html:p>
<html:p>SUBSYSTEM: capsanthin and capsorubin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__131" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAPSANTHIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5781" name="Diacylglycerol cholinephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AAPT1 ) or ( CPT1 ) or ( AAPT2 ) or ( AAPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( cholinephosphotransferase 1 ) or ( aminoalcoholphosphotransferase ) or ( aminoalcoholphosphotransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.2</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7946" name="capsanthin/capsorubin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CCS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( capsanthin-capsorubin synthase )</html:p>
<html:p>SUBSYSTEM: capsanthin and capsorubin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__133" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAPSORUBIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8677" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSD_Fi1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dirigent protein subunit )</html:p>
<html:p>SUBSYSTEM: matairesinol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CONIFERYL__45__ALCOHOL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8905" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__61__45__RXN" name="4-hydroxymuconic-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pnpD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrophenol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.61</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXYMUCONIC__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8675" name="Uroporphyrinogen-III C-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( corA ) or ( cysG ) or ( cobA ) or ( cysG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen-III C-methyltransferase subunit ) or ( CysG ) or ( CobA ) or ( uroporphyrinogen-III C-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: factor 430 biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8679" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PLR-Fi1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PLR subunit )</html:p>
<html:p>SUBSYSTEM: matairesinol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8907" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8909" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__12__46__4__45__RXN" name="3-hydroxy-2-methylpyridinecarboxylate dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vitamin B6 degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.4</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1071" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__565" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8678" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PLR-Fi1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PLR subunit )</html:p>
<html:p>SUBSYSTEM: matairesinol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8905" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8907" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__78__45__RXN" name="Ent-kaurene oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-4 ) or ( KO1 ) or ( KO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ent-kaurene oxidase ) or ( ent-kaurene oxidase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>SUBSYSTEM: superpathway of GA12 biosynthesis</html:p>
<html:p>SUBSYSTEM: GA12 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.78</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__128" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ENT__45__KAUR__45__16__45__EN__45__19__45__OL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__NUCLEOSID__45__RXN" name="AMP nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( amn )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Amn )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE__45__5P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8694" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AB181292 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lupanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CPD__45__1083</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1083" stoichiometry="1"/>
      <speciesReference species="_13__45__HYDROXYLUPININE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__8918" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8695" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP81Q2 ) or ( CYP81Q1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sesamin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8905" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8921" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__CARBOXYMETHYL__45__HYDROXYMUCONATE__45__AUTO__45__RXN" name="5-carboxymethyl-2-hydroxymuconate autotransformation" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__784" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__785" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R527__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mcrB and mcrA and mcrG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta; subunit and &amp;alpha; subunit and &amp;gamma; subunit )</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__681" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="CPD__45__845" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOACETATE__45__DECARBOXYLASE__45__RXN" name="Acetoacetate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( adc ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Adc ) or ( NA )</html:p>
<html:p>SUBSYSTEM: acetone degradation I (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANIDINOBUTYRASE__45__RXN" name="Guanidinobutyrase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( gbuA ) or ( gbh ) or ( gbuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( guanidinobutyrase subunit ) or ( guanidinobutyrase subunit ) or ( guanidinobutyrase subunit ) or ( guanidinobutyrase subunit )</html:p>
<html:p>SUBSYSTEM: arginine degradation X (arginine monooxygenase pathway)</html:p>
<html:p>SUBSYSTEM: arginine degradation VIII (arginine oxidase pathway)</html:p>
<html:p>SUBSYSTEM: arginine degradation IX (arginine:pyruvate transaminase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.7</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__592" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__278__45__RXN" name="3-&amp;beta;-hydroxy-5-&amp;alpha;-steroid dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cardenolide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.278</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__293" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__BETA__45__HYDROXY__45__5__45__ALPHA__45__PREGNANE__45__20__45__ONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="YIAE1__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ghrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GhrB )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_25__45__DIDEHYDRO__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__DEHYDROGLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8686" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HvCOMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gramine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8913" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8914" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R141__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ahy )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: acetylene degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.112</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYLENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6425" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6123" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6122" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6424" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6121" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6123" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8688" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lupanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CADAVERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8919" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAPDHSYNEC__45__RXN" name="Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)) (phosphorylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( gap2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gap2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.59</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8687" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HvCOMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gramine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8914" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8915" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6423" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: putrescine degradation IV</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6124" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6421" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAO1 ) or ( BPAO2 ) or ( MPAO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( polyamine oxidase ) or ( polyamine oxidase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.11</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
      <speciesReference species="CPD__45__6121" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANDELATE__45__RACEMASE__45__RXN" name="Mandelate racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdlA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: mandelate degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__121" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__122" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7162" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPK2&amp;alpha; ) or ( IPK2&amp;beta; )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipid-dependent phytate biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis I (via Ins(1,4,5)P3)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( IPK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3)</html:p>
<html:p>SUBSYSTEM: lipid-independent phytate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of lipid-dependent phytate biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis I (via Ins(1,4,5)P3)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1107" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOGLUCOSE__45__REDUCTASE__45__RXN" name="3-ketoglucose-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sucrose degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEHYDRO__45__ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGINASE__45__RXN" name="Arginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAR1 ) or ( ARG2 ) or ( arcA ) or ( rocF ) or ( ARG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase subunit ) or ( Arg2 monomer ) or ( arginase subunit ) or ( NA ) or ( ARG1 monomer )</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation VII (arginase 3 pathway)</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7929" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ccl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( citryl-coA lyase subunit )</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle II</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.34</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3S__45__CITRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7921" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hf1 ) or ( Hf2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: leucodelphinidin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6994" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7214" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLGALLATE__45__RXN" name="Protocatechuate 4,5-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PmdB and PmdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protocatechuate 4,5-dioxygenase &amp;beta; subunit and protocatechuate 4,5-dioxygenase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: methylgallate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: METOH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__721" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__184" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="APIGNAR__45__RXN" name="Chalcone isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( OJ1754_E06.14 ) or ( AT5g05270 ) or ( AT3g55120 ) or ( At1g53520 ) or ( AT5g66220 ) or ( CHI_MAIZE ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chalcone isomerase ) or ( chalcone isomerase ) or ( chalcone isomerase ) or ( chalcone isomerase ) or ( chalcone isomerase ) or ( chalcone isomerase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: flavonoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APIGENIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NARINGENIN__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8671" name="Flavonoid 3&apos;,5&apos;-hydroxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hf1 ) or ( Hf2 ) or ( TG1 ) or ( AJ011862 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.88</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Hydroxy__45__Flavanones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__5__45__Dihydroxy__45__Flavanones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCHOMOSERLYASE__45__RXN" name="O-succinylhomoserine (thiol)-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( metB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MetB )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.48</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ANTHRANILOYL__45__COA__45__MONOOXYGENASE__45__RXN" name="Anthraniloyl-CoA monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( abmA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-amninobenzoyl-CoA monooxygenase/reductase subunit )</html:p>
<html:p>SUBSYSTEM: anthranilate degradation II (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.40</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINOBENZOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__5__45__OXOCYCLOHEX__45__1__45__ENECARBOXYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZOYLFORMATE__45__DECARBOXYLASE__45__RXN" name="Benzoylformate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdlC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MdlC )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: mandelate degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.7</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__3__46__1__46__23__45__RXN" name="5-methylthioribose-1-phosphate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-pmtr isomerase subunit )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.23</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1063" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4201" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: medicarpin conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.170</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3402" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4122" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPOXANPRIBOSYLTRAN__45__RXN" name="Hypoxanthine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hpt ) or ( hpt ) or (  ) or (  ) or ( gpt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine-guanine phosphoribosyltransferase ) or ( NA ) or ( NA ) or ( NA ) or ( Gpt )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4204" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: medicarpin conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.115</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4122" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4123" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4206" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: medicarpin conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4123" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4122" stoichiometry="1"/>
      <speciesReference species="MALONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4207" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: medicarpin conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4122" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__3402" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4208" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>SIDE: __124__Methylated__45__methyl__45__acceptors__124__</html:p>
<html:p>SIDE: __124__Methyl__45__acceptors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Methyl__45__acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__4124" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Methylated__45__methyl__45__acceptors__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__4125" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DAD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DAD1 )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: jasmonic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__1__45__Acylglycero__45__Phosphocholines__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="LINOLENIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4209" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;7-sterol-C5-desaturase )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4125" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4126" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7931" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( fadB ) or ( fadJ ) or ( MFP-a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-3, delta2-enoyl-CoA isomerase ) or ( MFP III ) or ( MFP II ) or ( dodecenoyl-CoA &amp;delta;-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase ) or ( FadJ monomer ) or ( MFP a )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7221" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8666" name="Versatile peroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( vpl1 ) or ( vpl2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( versatile peroxidase VPL1 ) or ( versatile peroxidase VPL2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10474" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10475" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7933" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( argE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylcitrulline deacetylase subunit )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7224" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUGAR__45__PHOSPHATASE__45__RXN" name="Sugar-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yfbT ) or ( yigL ) or ( ybiV ) or ( yidA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sugar phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.23</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sugar__45__Phosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Sugar__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R604__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dbfB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dibenzo-p-dioxin degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__923" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__924" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R241__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__PHENYLPROPIONATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__503" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYL__45__KIN__45__RXN" name="Guanylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gmk ) or ( gmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( Gmk )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: guanosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BANMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine betaine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6142" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BANMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine betaine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.49</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6141" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__71__45__RXN" name="N-methylcoclaurine 3&apos;-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP80B1v1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (S)-reticuline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.71</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__N__45__METHYLCOCLAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__N__45__METHYL__45__S__45__COCLAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__RXN" name="Tryptophanase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tnaA ) or (  ) or ( tnaA ) or ( tna1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TnaA ) or ( tryptophanase subunit ) or ( tryptophanase subunit ) or ( tryptophanase subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation II (via pyruvate)</html:p>
<html:p>SUBSYSTEM: indigo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.99.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7908" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PCBD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pterin-4&amp;alpha;-carbinolamine dehydratase subunit )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.96</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIOHBUTANONEPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ribB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,4-dihydroxy-2-butanone 4-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.99.12</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__BUTANONE__45__P" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__9__46__3__45__RXN" name="Selenide,water dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( selD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: selenocysteine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__678" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SEPO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__2__46__1__46__29__45__RXN" name="3-&amp;alpha;,7-&amp;alpha;,12-&amp;alpha;-trihydroxy-5-&amp;beta;-cholestanate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Slc27a5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bile acid CoA ligase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.7</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1836" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__71" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ndk ) or ( NME2 and NME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ndk ) or ( nucleoside diphosphate kinase B and nucleoside diphosphate kinase A )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: guanosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__5__46__1__45__RXN" name="Glutathione dehydrogenase (ascorbate)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ascorbate glutathione cycle</html:p>
<html:p>PROTEIN_CLASS: 1.8.5.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__5__45__DEHYDROGENASE__45__RXN" name="Shikimate 5-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aroD ) or ( aroE ) or ( ydiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.25</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Glycine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AF216283 ) or ( AB094497 ) or ( AF216281 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis IV (from glycine)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.156</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R424__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( camA and camB and camC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P-450cam and NADH-putidaredoxin reductase and putidaredoxin )</html:p>
<html:p>SUBSYSTEM: adamantanone degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__745" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__746" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6464" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BANMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine betaine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6142" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6181" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__19__45__RXN" name="Nucleoside-triphosphate pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mazG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside triphosphate pyrophosphohydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__OCTOPINE__45__DEHYDROGENASE__45__RXN" name="D-octopine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ooxA and ooxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( octopine oxidase subunit A and octopine oxidase subunit B )</html:p>
<html:p>SUBSYSTEM: octopine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.11</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__309" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__15__45__RXN" name="Benzoyl-CoA reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bcrA and bcrB and bcrC and bcrD ) or ( badD and badE and badF and badG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzoyl-CoA reductase &amp;gamma; subunit and benzoyl-CoA reductase &amp;delta; subunit and benzoyl-CoA reductase &amp;beta; subunit and benzoyl-CoA reductase &amp;alpha; subunit ) or ( BadF and BadG and BadD and BadE )</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.15</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYCLOHEXA__45__15__45__DIENE__45__1__45__CARBONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__75__45__RXN" name="Long-chain-alcohol O-fatty-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( WS1 ) or ( WS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: wax esters biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.75</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__a__45__long__45__chain__45__alcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__a__45__long__45__chain__45__ester__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_14__45__BETA__45__D__45__XYLAN__45__SYNTHASE__45__RXN" name="1,4-&amp;beta;-D-xylan synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.24</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
      <speciesReference species="_14__45__BETA__45__D__45__XYLANS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_14__45__BETA__45__D__45__XYLANN1" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DURIDKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tdk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLGUANIDINASE__45__RXN" name="Methylguanidinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: creatinine degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.16</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__593" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLAMINE" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__97__46__1__46__8__45__RXN" name="Tetrachloroethene reductive dehalogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pceC ) or ( pceA ) or ( pceA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tetrachloroethene reductive dehalogenase subunit ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrachloroethene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.8</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRACHLOROETHENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CL__45__" stoichiometry="1"/>
      <speciesReference species="TRICHLOROETHENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINBBSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-hexachlorocyclohexane degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_245__45__DNOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_25__45__DICHLOROPHENOL" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8698" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (S)-tetrahydroprotoberberine oxidase )</html:p>
<html:p>SUBSYSTEM: palmatine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__TETRAHYDROCOLUMBAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COLUMBAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (S)-tetrahydroprotoberberine oxidase )</html:p>
<html:p>SUBSYSTEM: palmatine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRAHYDROPALMATINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMATINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8696" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP81Q2 ) or ( CYP81Q1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sesamin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8921" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8922" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8697" name="cyclohexane hydroxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bmoB and bmoC and bmoX and bmoY and bmoZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( soluble butane monooxygenase hydroxylase component &amp;beta; subunit and soluble butane monooxygenase hydroxylase component &amp;alpha; subunit and soluble butane monooxygenase reductase component and soluble butane monooxygenase regulatory component and soluble butane monooxygenase hydroxylase component &amp;gamma; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8923" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYCLOHEXANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="VINYLACETYL__45__COA__45__DELTA__45__ISOMERASE__45__RXN" name="Vinylacetyl-CoA &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( abfD ) or (  ) or ( Msed_1220 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybutyryl-CoA dehydratase subunit ) or ( 4-hydroxybutyryl-CoA dehydratase subunit ) or ( vinylacetyl-CoA &amp;Delta;-isomerase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: succinate fermentation to butyrate</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation II</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__226" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSCHOL__45__RXN" name="Phospholipase D" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PLD delta ) or ( L33686 ) or ( PLD beta ) or ( PLD zeta ) or ( PLD gamma ) or ( PLD alpha )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PLD &amp;delta; ) or ( NA ) or ( PLD &amp;beta; ) or ( PLD &amp;zeta; ) or ( PLD &amp;gamma; ) or ( PLD &amp;alpha; )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__58__45__RXN" name="Lipopolysaccharide glucosyltransferase I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose:(glucosyl)LPS &amp;alpha;-1,2-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.58</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Lipopolysaccharides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8523" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__150__45__RXN" name="Salutaridinol 7-O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( salAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( salutaridinol-7-O-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: morphine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.150</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SALUTARIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__O__45__ACETYLSALUTARIDINOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOTHENATE__45__KIN__45__RXN" name="Pantothenate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtPANK1 ) or ( AtPANK2 ) or ( coaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantothenate kinase 1 ) or ( NA ) or ( pantothenate kinase monomer )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis III</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHINE__45__OXIDASE__45__RXN" name="Xanthine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Xdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine oxidase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__288__45__RXN" name="Xanthoxin dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ABA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: abscisic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.288</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__92" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__692" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__6__45__METHOXYPHENOL__45__HYDROX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.14.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__METHOXYPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__METHOXY__45__BENZOQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__METHYLENEGLUTARATE__45__MUTASE__45__RXN" name="2-methyleneglutarate mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mgm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-methyleneglutarate mutase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation III</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__CH2__45__GLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2CH2__45__3CH3__45__SUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINEOXID__45__RXN" name="Amine oxidase (copper-containing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ATAO1 ) or ( tynA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( copper amine oxidase ) or ( TynA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.21</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TOLUENE__45__SIDE__45__CHAIN__45__MONOOXYGENASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ntnA and ntnM ) or ( xylA and xylM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-nitrotoluene monooxygenase reductase component and 4-nitrotoluene monooxygenase hydroxylase component ) or ( NADH-acceptor-reductase subunit of xylene monooxygenase and hydroxylase subunit of xylene monooxygenase )</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation IV (aerobic) (via catechol)</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoate</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TOLUENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__22__45__RXN" name="3,4-dihydroxyphenylalanine reductive deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,4-dihydroxyphenylalanine reductive deaminase &amp;alpha; subunit and 3,4-dihydroxyphenylalanine reductive deaminase &amp;beta; subunit and 3,4-dihydroxyphenylalanine reductive deaminase &amp;gamma; subunit and 3,4-dihydroxyphenylalanine reductive deaminase &amp;delta; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.22</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__DIHYDROXYPHENYL__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1541" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IFS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3161" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTCYCLOHYD__45__RXN" name="Phosphoribosyl-AMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At-IE ) or ( hisI ) or ( hisI-E )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1484" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LAR ) or ( LcLAR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( leucoanthocyanidin reductase ) or ( leucoanthocyanidin reductase )</html:p>
<html:p>SUBSYSTEM: proanthocyanidin biosynthesis from flavanols</html:p>
<html:p>SUBSYSTEM: 2,3-trans-flavanols biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__590" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNI__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HP0692 and HP0691 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl-CoA:acetoacetate CoA-transferase subunit B and succinyl-CoA:acetoacetate CoA-transferase subunit A )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>SIDE: _3__45__KETOBUTYRATE</html:p>
<html:p>SIDE: ACETOACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9309" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: staphyloxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD__45__9917</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9915" stoichiometry="1"/>
      <speciesReference species="CPD__45__9917" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9916" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNI__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HP0086 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate:quinone oxidoreductase )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: REDUCED__45__MENAQUINONE</html:p>
<html:p>SIDE: CPD__45__9728</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9728" stoichiometry="1"/>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
      <speciesReference species="REDUCED__45__MENAQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrosqualene desaturase )</html:p>
<html:p>SUBSYSTEM: staphyloxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9910" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9911" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8604" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8803" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9306" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaponeurosporene oxidase )</html:p>
<html:p>SUBSYSTEM: staphyloxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9911" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9912" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8603" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8801" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9307" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaponeurosporene oxidase )</html:p>
<html:p>SUBSYSTEM: staphyloxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9912" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9913" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8602" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8802" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: staphyloxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Nucleoside__45__Diphosphates__124__</html:p>
<html:p>SIDE: __124__NDP__45__glucoses__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__NDP__45__glucoses__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__9913" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9915" stoichiometry="1"/>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8601" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8804" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEPHOSPHOCOAKIN__45__RXN" name="Dephospho-CoA kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtCoaE ) or ( coaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis III</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9301" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: staphyloxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9906" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENZRXN__45__161__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aad ) or ( bdhA ) or ( bdhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( BdhA ) or ( BdhB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTANAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrosqualene desaturase )</html:p>
<html:p>SUBSYSTEM: staphyloxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9906" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9908" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2007" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salicylate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__110" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crtN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dehydrosqualene desaturase )</html:p>
<html:p>SUBSYSTEM: staphyloxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9908" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9910" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9310" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( menH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis II (plants)</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.99.20</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9924" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__9923" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHTHALATE__45__45__45__DIOXYGENASE__45__RXN" name="Phthalate 4,5-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( padAb1 and padAc1 and padAa1 and padAd1 ) or ( padAc2 and padAd2 and padAa2 and padAb2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phthalate 3,4-dioxygenase beta subunit and phthalate 3,4-dioxygenase alpha subunit and phthalate 3,4-dioxygenase ferredoxin reductase subunit and phthalate 3,4-dioxygenase ferredoxin subunit ) or ( phthalate 3,4-dioxygenase ferredoxin subunit and phthalate 3,4-dioxygenase beta subunit and phthalate 3,4-dioxygenase ferredoxin reductase subunit and phthalate 3,4-dioxygenase alpha subunit )</html:p>
<html:p>SUBSYSTEM: phthalate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.7</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHTHALATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__45__45__DIHYDROXYCYCLOHEXA__45__162__45__DIENE__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__255__45__RXN" name="Mannitol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MTD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: mannitol degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.255</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OH__45__6__45__OXOHEPTA__45__2__45__4__45__DIENOATE__45__HYDR__45__RXN" name="2-hydroxy-6-oxohepta-2,4-dienoate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( todF ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase ) or ( 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate (via 4-methylcatechol)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: 4-toluenesulfonate degradation II</html:p>
<html:p>SUBSYSTEM: toluene degradation II (aerobic) (via 4-methylcatechol)</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate I (via o-cresol)</html:p>
<html:p>SUBSYSTEM: toluene degradation V (aerobic) (via toluene-cis-diol)</html:p>
<html:p>SUBSYSTEM: 2-nitrotoluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation I (aerobic) (via o-cresol)</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate (via toluene-cis-diol)</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2H6OH2__45__4DIENOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXOPENTENOATE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCPHOSDIESTER__45__RXN" name="2&apos;,3&apos;-cyclic-nucleotide 2&apos;-phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cpdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.16</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__2__45__3__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVINKIN__45__RXN" name="ATP-dependent riboflavin kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ribF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional riboflavin kinase / FMN adenylyltransferase )</html:p>
<html:p>SUBSYSTEM: 5,6-dimethylbenzimidazole biosynthesis</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R17__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sqr ) or ( sqr ) or ( sqr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sulfide oxidation I (sulfide-quinone reductase)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfide oxidation (Acidithiobacillus ferrooxidans)</html:p>
<html:p>PROTEIN_CLASS: 1.8.5.-</html:p>
<html:p>SIDE: __124__Reduced__45__Quinones__124__</html:p>
<html:p>SIDE: __124__Quinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9314" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP80G2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: magnoflorine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__RETICULINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9935" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9315" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AB061863 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( coclaurine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: magnoflorine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9935" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9936" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9312" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: t-anethole biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9933" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9930" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__FORMYL__45__THF__45__CYCLO__45__LIGASE__45__RXN" name="5-formyltetrahydrofolate cyclo-ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FAU1 ) or ( AtFCL ) or (  ) or ( LeFCL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methenyltetrahydrofolate synthetase ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PREPHENATEDEHYDRAT__45__RXN" name="Prephenate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pheA ) or ( pheA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PheA ) or ( PheA )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.51</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( invertase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.26</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NP ) or ( deoD ) or (  ) or ( deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase subunit ) or ( DeoD ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMETB12__45__RXN" name="5-methyltetrahydrofolate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Mtr ) or ( metH ) or ( metH ) or ( MTR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( 5-methyltetrahydrofolate--homocysteine methyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (by sulfhydrylation)</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9333" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: epoxypseudoisoeugenol-2-methylbutyrate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9933" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9943" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9332" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: epoxypseudoisoeugenol-2-methylbutyrate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COUMARYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9933" stoichiometry="1"/>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R608__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( H1 subunit of 2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoic acid hydrolase and H2 subunit of 2-hydroxy-6-oxo-6-phenyl-2,4-hexadienoic acid hydrolase )</html:p>
<html:p>SUBSYSTEM: dibenzofuran degradation</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__110</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__928" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXOPENTENOATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__110" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__2__46__1__46__10__45__RXN" name="2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3,5-dichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__2__45__CHLORO__45__4__45__CARBOXYMETHYLENEBUT__45__2__45__E" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__2__45__CHLORO__45__4__45__CARBOXYMETHYLENEBUT__45__2__45__EN__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__1__46__2__45__RXN" name="Precorrin-8X methylmutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin-8x methylmutase subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 5.4.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__686" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__687" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R82__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mtnW ) or ( masA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-diketo-5-methylthiopentyl-1-phosphate enolase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__84" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXY__45__3__45__KETO__45__5__45__METHYLTHIO__45__1__45__PHOSPHOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMATE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Glutamate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ECM40 ) or ( argJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylornithine acetyltransferase ) or ( ArgJ )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.35</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIAZOLSYN3__45__RXN" name="Hydroxyethylthiazole kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( thiM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyethylthiazole kinase )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.50</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THZ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THZ__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYLGLUCOSAMINE__45__4__45__EPIMERASE__45__RXN" name="UDP-N-acetylglucosamine 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GALE ) or ( galE ) or ( wbgU ) or ( wbpP ) or ( UAE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-galactose 4-epimerase ) or ( UDP-galactose 4-epimerase subunit ) or ( UDP-N-acetylglucosamine C4-epimerase subunit ) or ( UDP-N-acetylglucosamine C4-epimerase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9344" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: wax esters biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="VERY__45__LONG__45__CHAIN__45__FATTY__45__ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="__124__a__45__long__45__chain__45__alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPDEPHOS__45__RXN" name="Pyruvate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pykA ) or (  ) or ( pykF ) or ( pyk ) or ( TM0208 ) or ( pyk ) or (  ) or (  ) or ( pyk ) or (  ) or ( pykF ) or ( PF1188 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate kinase II monomer ) or ( pyruvate kinase subunit ) or ( pyruvate kinase subunit ) or ( pyruvate kinase subunit ) or ( pyruvate kinase subunit ) or ( pyruvate kinase subunit ) or ( pyruvate kinase &amp;beta; subunit and pyruvate kinase &amp;alpha; subunit ) or ( pyruvate kinase ) or ( pyruvate kinase subunit ) or ( pyruvate kinase subunit ) or ( pyruvate kinase I monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: glycolysis IV (plant cytosol)</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.40</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTACONATE__45__COA__45__TRANSFERASE__45__RXN" name="glutaconate CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( gctA and gctB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GctA and GctB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTACONATE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTACONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMTRANSAM__45__RXN" name="Diamine aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ygjG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.29</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aliphatic__45__Omega__45__Amino__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCOSE__45__46__45__DEHYDRATASE__45__RXN" name="UDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RHM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-L-rhamnose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.76</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__663" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYDTER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tsaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TsaD )</html:p>
<html:p>SUBSYSTEM: 4-toluenecarboxylate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CARBOXYBENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TEREPHTHALATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOPORGENOXI__45__RXN" name="Protoporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PPOX ) or ( PPXII ) or ( PPOX ) or ( hemG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoporphyrinogen oxidase ) or ( protoporphyrinogen IX oxidase isozyme II ) or ( protoporphyrinogen oxidase monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen II</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.4</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8645" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( serA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SerA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.2</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXYGLUTARIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARVEOL__45__DEHYDROGENASE__45__RXN" name="Carveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ISPD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (4R)-carvone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.243</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10051" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1089" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__118__45__RXN" name="Columbamine O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CoOMT ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: palmatine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.118</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COLUMBAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMATINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PADENYLTRANS__45__RXN" name="Glucose-1-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STGLS and STGLL ) or ( ApL1 and ApS1 ) or ( glgC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-glucose pyrophosphorylase small subunit and ADP-glucose pyrophosphorylase ) or ( ADP-glucose pyrophosphorylase large subunit and ADP-glucose pyrophosphorylase small subunit ) or ( GlgC )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.27</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__PANTOCYSDECARB__45__RXN" name="Phosphopantothenoylcysteine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtCoaC ) or ( dfp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis III</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.36</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__4__45__PHOSPHOPANTOTHENOYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__HALOACID__45__DEHALOGENASE__45__RXN" name="2-haloacid dehalogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dhlB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DhlB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__2__45__Haloacids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__R__45__2__45__Hydroxyacids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Halides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTATEKIN__45__RXN" name="Aspartate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lysC&amp;alpha; and lysC&amp;beta; ) or (  ) or ( AT3G02020 ) or ( lysC&amp;alpha; and lysC&amp;beta; ) or ( yclM ) or ( thrA ) or ( metL ) or ( lysC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartate kinase II &amp;alpha; subunit and aspartate kinase II &amp;beta; subunit ) or ( NA ) or ( NA ) or ( aspartokinase &amp;beta; subunit and aspartokinase &amp;alpha; subunit ) or ( aspartate kinase III ) or ( ThrA ) or ( MetL ) or ( LysC )</html:p>
<html:p>SUBSYSTEM: ectoine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis III</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis II</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (by sulfhydrylation)</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis VI</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__BETA__45__ASPARTYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2NEOPTERINP3PYROPHOSPHOHYDRO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nudB ) or ( folQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroneopterin triphosphate pyrophosphohydrolase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__METHYLCITRATE__45__SYNTHASE__45__RXN" name="2-methylcitrate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( prpC ) or ( prpC ) or ( prpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle I</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle II</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.5</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: OXALACETIC_ACID</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__622" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LONG__45__CHAIN__45__ALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Long-chain-aldehyde dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALD2 ) or ( ALDH2 ) or ( ALD4 ) or ( ALD5 ) or ( alkH ) or ( ALD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( aldehyde dehydrogenase class 2 subunit ) or ( potassium-activated aldehyde dehydrogenase, mitochondrial ) or ( aldehyde dehydrogenase, mitochondrial ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.48</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOACONITATE__45__HYDRATASE__45__RXN" name="Homoaconitate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS4 ) or ( lysU and lysT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homoaconitase ) or ( homoaconitase large subunit and homoaconitase small subunit )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.36</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__I__45__CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP2A6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 2A6 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLYLSULFKIN__45__RXN" name="Adenylylsulfate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AKN1 ) or ( met14 ) or ( cysC ) or ( AKN2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( Met14 ) or ( CysC ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (by sulfhydrylation)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.25</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8635" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: betanidin degradation</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.7</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8653" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8890" stoichiometry="1"/>
      <speciesReference species="CPD__45__8653" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-alanine aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8636" name="Methylglyoxal reductase (NADPH-dependent)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GRE2 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lactate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation IV</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation V</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.283</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__27__45__RXN" name="Sphingomyelin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sgms1 ) or ( Sgms2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingomyelin synthase 1 ) or ( sphingomyelin synthase 2 )</html:p>
<html:p>SUBSYSTEM: sphingomyelin metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.27</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>SIDE: PHOSPHATIDYLCHOLINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ceramides__124__" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Sphingomyelins__124__" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__3__46__9__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( argF&apos; )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylornithine transcarbamylase subunit )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7224" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8630" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP2E1 ) or ( Cyp2e1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 2E1 ) or ( cytochrome P450 2E1 )</html:p>
<html:p>SUBSYSTEM: acetone degradation I (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8631" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosolic fructose-bisphosphate aldolase ) or ( chloroplastic fructose-bisphosphate aldolase ) or ( chloroplastic fructose-bisphosphate aldolase ) or ( cytosolic fructose-bisphosphate aldolase ) or ( cytosolic fructose-bisphosphate aldolase ) or ( chloroplastic fructose-bisphosphate aldolase ) or ( cytosolic fructose-bisphosphate aldolase ) or ( chloroplastic fructose-bisphosphate aldolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="APIGENIN__45__4__45__O__45__METHYLTRANSFERASE__45__RXN" name="Apigenin 4&apos;-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: acacetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.75</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__431" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1095" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8632" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1B1 ) or ( gldA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( GldA )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPANE__45__1__45__2__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8639" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation VIII</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.49</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__161__45__RXN" name="Beta-apiosyl-beta-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dnbglu2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-O--D-apiofuranosyl-(1-6)-&amp;beta;-D-glucopyranosidase )</html:p>
<html:p>SUBSYSTEM: dalpatein and dalnigrein biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__9004</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9695" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="CPD__45__9716" stoichiometry="1"/>
      <speciesReference species="CPD__45__9004" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TEICHOICSYN3__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tagB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: teichoic acid (poly-glycerol) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__ETCETERA__45__GLUCOSAMINYLDIPHOSPHOUND" stoichiometry="1"/>
      <speciesReference species="CPD__45__606" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5802" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMIMINOGLUTAMATE__45__DEIMINASE__45__RXN" name="Formiminoglutamate deiminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hutF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formiminoglutamate deiminase subunit )</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.13</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__FORMIMINO__45__L__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__600" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8621" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sesquiterpene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8849" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8622" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sesquiterpene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8850" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8625" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betacyanin biosynthesis (via dopamine)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8853" stoichiometry="1"/>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8854" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8626" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pduX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: aminopropanol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__THREONINE__45__O__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit 1 tyrosinase and subunit 2 tyrosinase )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betacyanin biosynthesis (via dopamine)</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8851" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8624" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betacyanin biosynthesis (via dopamine)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8851" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8853" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPOXYGENASE__45__RXN" name="Lipoxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 13-LOX and 13-HPL pathway</html:p>
<html:p>SUBSYSTEM: divinyl ether biosynthesis II (13-LOX)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.12</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LINOLEIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_13__45__HYDROPEROXYOCTADECA__45__911__45__DIENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2201" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ydfG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy acid dehydrogenase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.276</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOMALONATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R147__45__RXN" name="Acireductone dioxygenase (Fe(2+)-requiring)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.54</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SINAPATE__45__1__45__GLUCOSYLTRANSFERASE__45__RXN" name="Sinapate 1-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SGT1 ) or ( UGT84A2 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sinapate ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.120</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SINAPATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__O__45__SINAPOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADDALT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( add )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYINOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYXISOM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rhaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-rhamnose isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-lyxose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__LYXOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP2A6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 2A6 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2750" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP2A6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 2A6 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2751" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PORPHOBILSYNTH__45__RXN" name="Porphobilinogen synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hemB ) or ( HEMB1 ) or ( hemB ) or ( hemB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( porphobilinogen synthase subunit ) or ( aminolevulinate dehydratase ) or ( &amp;delta;-aminolevulinate dehydratase subunit ) or ( porphobilinogen synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.24</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__168" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A4 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2747" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__169" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP2A6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 2A6 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3188" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8612" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,2-dihydroxynaphthalene dioxygenase subunit )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAPHTHALENE__45__12__45__DIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPDN__45__384" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PUTRESCINE__45__OXIDASE__45__RXN" name="Putrescine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( puo ) or ( ATAO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putrescine oxidase subunit ) or ( copper amine oxidase )</html:p>
<html:p>SUBSYSTEM: putrescine degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.10</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8615" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPDN__45__385" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SALICYLALDEHYDE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8616" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( TPS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: DMNT biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8843" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8617" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__TRANS6__45__TRANS__45__FARNESOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8618" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PcTps-EK ) or ( PcTps-C ) or ( TPS1 ) or ( GES ) or ( GES ) or ( PfTps-PL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( C-geraniol synthase ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: geraniol and geranial biosynthesis</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__13__46__11__46__15__45__RXN" name="3,4-dihydroxyphenylacetate 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hpaB ) or ( hpcB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,4-dihydroxyphenylacetate dioxygenase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.15</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__783" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__79__45__RXN" name="Ent-kaurenoic acid oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-1 ) or ( KAO1 ) or ( KAO1 ) or ( KAO2 ) or ( KAO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>SUBSYSTEM: superpathway of GA12 biosynthesis</html:p>
<html:p>SUBSYSTEM: GA12 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__132" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__136" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DALADALALIG__45__RXN" name="D-alanine--D-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ddlA ) or ( ddlB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ddlB )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALA__45__D__45__ALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FHLMULTI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fdhF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formate hydrogenlyase complex iron-sulfur protein and hydrogenase 3, large subunit and hydrogenase 3, membrane subunit and NA and hydrogenase 3, Fe-S subunit and hydrogenase 3, membrane subunit and hydrogenase 3 and formate hydrogenlyase complex, HycG subunit )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__43__45__RXN" name="Polygalacturonate 4-&amp;alpha;-galacturonosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha; 1,4-galacturonosyltransferase ) or ( &amp;alpha; 1,4-galacturonosyltransferase )</html:p>
<html:p>SUBSYSTEM: homogalacturonan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.43</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__galacturonosyl__124__" stoichiometry="1"/>
      <speciesReference species="UDP__45__D__45__GALACTURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__galacturonosyl__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="POLYAMINE__45__OXIDASE__45__RXN" name="Polyamine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FMS1 ) or ( PAO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyamine oxidase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N1__45__ACETYLSPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
      <speciesReference species="CPD__45__568" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9395" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Iso__45__dihydrocarvones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__isopropenyl__45__3__45__methyloxepan__45__2__45__one__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="myo-inositol-1-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ino1 ) or (  ) or ( AF1794 ) or ( MIPS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol-1-phosphate synthase subunit ) or ( MIPS subunit ) or ( inositol-1-phosphate synthase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-independent phytate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9394" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mlhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;epsilon;-lactone hydrolase )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.83</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10044" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10047" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PPENTOMUT__45__RXN" name="Phosphopentomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( deoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9393" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mlhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;epsilon;-lactone hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.83</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__isopropenyl__45__7__45__methyloxepan__45__2__45__one__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__Hydroxy__45__3__45__isopropenylheptanoates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9392" name="dihydrocarveol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+-dependent dihydrocarveol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.296</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10030" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10039" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9391" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: (4R)-carveol and (4R)-dihydrocarveol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10039" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10044" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9390" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monocyclic monoterpene ketone monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Dihydrocarvones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__4__45__isopropenyl__45__7__45__methyloxepan__45__2__45__one__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP2B6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: bupropion degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3481" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3483" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__2__45__MONOOXYGENASE__45__RXN" name="Tryptophan 2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tms1 ) or ( iaaM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis VI (via indole-3-acetamide)</html:p>
<html:p>PROTEIN_CLASS: 1.13.12.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__237" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGENSYN__45__RXN" name="Starch (bacterial glycogen) synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( potato starch synthase I ) or (  ) or ( potato starch synthase III ) or (  ) or ( glgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( starch synthase I ) or ( GBSSI ) or ( starch synthase III ) or ( GBSSII ) or ( GlgA )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.21</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__92" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( UGT72E1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: monolignol glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SINAPALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__79" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R217__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksD ) or ( aksE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__319" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__336" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__90" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: monolignol glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.111</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SINAPYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__63" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__91" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( UGT72E1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: monolignol glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CONIFERYL__45__ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__81" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2081" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homogalacturonan methyltransferase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: homogalacturonan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__galacturonosyl__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Methylesterified__45__homogalacturonan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1661" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fes )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enterochelin esterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ENTEROBACTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_23__45__DIHYDROXYBENZOYLSERINE__45__MULTIMERS" stoichiometry="3"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3522" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ascorbate glutathione cycle</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.4</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__318" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3521" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ascorbate glutathione cycle</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.11</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASCORBATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__318" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNB__45__RXN" name="asparagine synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Asns ) or ( asnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine synthetase subunit ) or ( AsnB )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of asparagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.4</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYL__45__METHOXY__45__BENZOQ__45__METH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase and S-adenosylmethionine:2-DMK methyltransferase )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__METHOXY__45__BENZOQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__METHYL__45__METHOXY__45__BENZQ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3523" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ascorbate glutathione cycle</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__318" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLSEROTONIN__45__O__45__METHYLTRANSFERASE__45__RXN" name="Acetylserotonin O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Asmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylserotonin O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: serotonin and melatonin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.4</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__SEROTONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__5__45__METHOXY__45__TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="C04718__45__C060066__45__AUTOTRANSFORMATION__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: 1,8-cineole degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__788" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__789" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEYLACETATE__45__REDUCTASE__45__RXN" name="Maleylacetate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( macA ) or ( pnpE ) or (  ) or ( clcE ) or ( tcbF ) or ( MAR ) or ( tfdFI ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( maleylacetate reductase ) or ( maleylacetate reductase subunit ) or ( NA ) or ( maleylacetate reductase subunit ) or ( maleylacetate reductase )</html:p>
<html:p>SUBSYSTEM: 4-chlorocatechol degradation</html:p>
<html:p>SUBSYSTEM: 3-chlorocatechol degradation</html:p>
<html:p>SUBSYSTEM: 3,5-dichlorocatechol degradation</html:p>
<html:p>SUBSYSTEM: 4-nitrophenol degradation I</html:p>
<html:p>SUBSYSTEM: 3,4-dichlorocatechol degradation</html:p>
<html:p>SUBSYSTEM: 4-nitrophenol degradation II</html:p>
<html:p>SUBSYSTEM: 3,4,6-trichlorocatechol degradation</html:p>
<html:p>SUBSYSTEM: chlorosalicylate degradation</html:p>
<html:p>SUBSYSTEM: resorcinol degradation</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-hexachlorocyclohexane degradation</html:p>
<html:p>SUBSYSTEM: 4-sulfocatechol degradation</html:p>
<html:p>SUBSYSTEM: 1,4-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.32</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETO__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__95" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: monolignol glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__94" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__82" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FLUORENE__45__OXYGENASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahAa and nahAb and nahAd and nahAc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha; subunit of naphthalene 1,2-dioxygenase terminal oxygenase and naphthalene 1,2-dioxygenase terminal oxygenase &amp;beta; subunit and naphthalene 1,2-dioxygenase component A and naphthalene 1,2-dioxygenase component C )</html:p>
<html:p>SUBSYSTEM: fluorene degradation I</html:p>
<html:p>SUBSYSTEM: fluorene degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FLUORENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_9FLUORENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETAGALACTOSID__45__RXN" name="&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lacZ ) or ( LacZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-galactosidase monomer ) or ( &amp;beta;-galactosidase subunit )</html:p>
<html:p>SUBSYSTEM: lactose degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMELATE__45__DEHYDROGENASE__45__RXN" name="Diaminopimelate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ddh ) or ( dapdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( meso-diaminopimelate D-dehydrogenase subunit ) or ( meso-diaminopimelate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 1.4.1.16</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALPHA__45__AMINO__45__EPSILON__45__KETO__45__PIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OXOADIPATE__45__COA__45__TRANSFERASE__45__RXN" name="3-oxoadipate CoA-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcaI and pcaJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha; subunit of &amp;beta;-ketoadipate succinyl-CoA transferase and &amp;beta; subunit of &amp;beta;-ketoadipate succinyl-CoA transferase )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: aromatic compounds degradation via &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: &amp;beta;-ketoadipate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation III (aerobic) (via p-cresol)</html:p>
<html:p>SUBSYSTEM: catechol degradation III (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.6</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
      <speciesReference species="_3__45__KETO__45__ADIPATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETO__45__ADIPYL__45__COA" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMBENCOATHAUERA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-aminobenzoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: anthranilate degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINOBENZOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__21__46__3__46__1__45__RXN" name="Isopenicillin-N synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcbC ) or ( PCBC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of penicillin, cephalosporin and cephamycin biosynthesis</html:p>
<html:p>SUBSYSTEM: isopenicillin N biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.21.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__5S__45__5__45__AMINO__45__5__45__CARBOXYPENTANOYL__45__L__45__CY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOPENICILLIN__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ARABINITOL__45__4__45__DEHYDROGENASE__45__RXN" name="L-arabinitol 4-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lad1 ) or ( ladA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARABITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__986" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( alkB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AlkB repair system for alkylated DNA and RNA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__ETHYLADENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITROETHANE__45__OXIDASE__45__RXN" name="Nitroethane oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NAO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitroalkane oxidase subunit )</html:p>
<html:p>SUBSYSTEM: nitroethane degradation</html:p>
<html:p>PROTEIN_CLASS: 1.7.3.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__320" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__216__45__RXN" name="Trehalose 6-phosphate phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trePP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: trehalose degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.216</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__448" stoichiometry="1"/>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__984" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( alkB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AlkB repair system for alkylated DNA and RNA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N1__45__METHYLADENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__985" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( alkB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AlkB repair system for alkylated DNA and RNA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N3__45__METHYLCYTOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOACYLCOATHIOL__45__RXN" name="Acetyl-CoA C-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcaF ) or (  ) or (  ) or ( AT2G33150 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of &amp;beta;-ketoadipyl CoA thiolase ) or ( 3-ketoacyl-CoA thiolase ) or ( FadI monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.16</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCLOHEXADIENYL__45__DEHYDROGENASE__45__RXN" name="Cyclohexadienyl dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.43</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__659" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R7__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gallate degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__20" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__OXIDASE__45__RXN" name="Aldehyde oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AOX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TOCOPHEROL__45__O__45__METHYLTRANSFERASE__45__RXN" name="Tocopherol O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( G-TMT ) or ( slr0089 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: vitamin E biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.95</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAMA__45__TOCOPHEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__TOCOPHEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3542" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: pterocarpan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.46</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DAIDZEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMONONETIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3541" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ascorbate glutathione cycle</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__318" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ESTRADIOL__45__17__45__BETA__45__DEHYDROGENASE__45__RXN" name="Estradiol 17 &amp;beta;-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD17B7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.62</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__352" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ESTRONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__190__45__RXN" name="Indole-3-acetaldehyde reductase (NADH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH5 ) or ( SFA1 ) or ( ADH1 ) or ( ADH4 ) or ( ADH3 ) or ( ADH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase V subunit ) or ( S-(hydroxymethyl)glutathione dehydrogenase subunit ) or ( alcohol dehydrogenase I subunit ) or ( alcohol dehydrogenase IV subunit ) or ( alcohol dehydrogenase III subunit ) or ( alcohol dehydrogenase II subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VIII (to tryptophol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.190</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__341" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SHIKIMATE__45__PQQ__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( quiA ) or ( quiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinate-shikimate dehydrogenase ) or ( quinate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: shikimate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.25</html:p>
<html:p>COFACTOR: PQQ</html:p>
<html:p>COFACTOR: CPD__45__104</html:p>
<html:p>SIDE: PQQ</html:p>
<html:p>SIDE: CPD__45__104</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGININE__45__DEIMINASE__45__RXN" name="Arginine deiminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( arcA ) or ( arcA ) or ( 3527597 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( ArcA ) or ( arginine deiminase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II (from arginine)</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>SUBSYSTEM: arginine degradation V (arginine deiminase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9352" name="epi-isozizaene 5-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCO5223 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( epi-isozizaene 5-monooxygenase )</html:p>
<html:p>SUBSYSTEM: albaflavenone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.106</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9960" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9962" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9353" name="epi-isozizaene 5-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCO5223 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( epi-isozizaene 5-monooxygenase )</html:p>
<html:p>SUBSYSTEM: albaflavenone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.106</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9962" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9350" name="epi-isozizaene 5-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCO5223 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( epi-isozizaene 5-monooxygenase )</html:p>
<html:p>SUBSYSTEM: albaflavenone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.106</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9959" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9960" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9351" name="epi-isozizaene 5-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCO5223 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( epi-isozizaene 5-monooxygenase )</html:p>
<html:p>SUBSYSTEM: albaflavenone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.106</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9959" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINESYN__45__RXN" name="Spermidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( speE ) or ( speE ) or ( SRM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SpeE ) or ( NA ) or ( spermidine synthase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTOSE__45__PHOSPHORYLASE__45__RXN" name="Maltose phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( malP ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maltose phosphorylase ) or ( maltose phosphorylase ) or ( maltose phosphorylase )</html:p>
<html:p>SUBSYSTEM: maltose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.8</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__448" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9349" name="epi-isozizaene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCO5222 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: albaflavenone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.37</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9959" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9348" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9958" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__10" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9347" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9957" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__9" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4641" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( murQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylmuramic acid 6-phosphate etherase )</html:p>
<html:p>SUBSYSTEM: 1,6-anhydro-N-acetylmuramic acid recycling</html:p>
<html:p>PROTEIN_CLASS: 4.2.-.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9346" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9956" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9345" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-7 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-7 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9955" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9717" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSAAMINOTRANS__45__RXN" name="Glutamate-1-semialdehyde 2,1-aminomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hemL ) or ( GSA1 ) or ( hemL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate-1-semialdehyde aminotransferase ) or ( glutamate-1-semialdehyde aminotransferase ) or ( glutamate-1-semialdehyde 2,1-aminomutase subunit )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTAMATE__45__1__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2043" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( KOR ) or ( bcsZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( endo-1,4-D-glucanase )</html:p>
<html:p>SUBSYSTEM: cellulose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERKIN__45__RXN" name="Homoserine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hsk ) or ( thrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ThrB )</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis from homoserine</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.39</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__78__45__RXN" name="Polyneuridine-aldehyde esterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PNAE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.78</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: METOH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLYNEURIDINE__45__ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_16__45__EPIVELLOSIMINE" stoichiometry="1"/>
      <speciesReference species="METOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLULOSE__45__REDUCTASE__45__RXN" name="D-xylulose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xdh1 ) or ( xdhA ) or (  ) or (  ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( sorbitol dehydrogenase subunit ) or ( NA ) or ( NA ) or ( sorbitol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: xylitol degradation</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__AMIDINOTRANSFERASE__45__RXN" name="Glycine amidinotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gatm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-arginine:glycine amidinotransferase subunit )</html:p>
<html:p>SUBSYSTEM: glycine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.4.1</html:p>
<html:p>SIDE: L__45__ORNITHINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="GUANIDOACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__133__45__RXN" name="Precorrin-4 C11-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.133</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCISOM__45__RXN" name="L-fucose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fucI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fucose degradation</html:p>
<html:p>SUBSYSTEM: superpathway of fucose and rhamnose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.25</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__FUCULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9356" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( WS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: wax esters biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CPD__45__7867</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7867" stoichiometry="1"/>
      <speciesReference species="CPD__45__9965" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__9966" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2981" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ill2 ) or ( iar3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indole-3-acetyl-ala hydrolase ) or ( indole-3-acetyl-ala hydrolase )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__ACETYL__45__ALA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATE__45__REDUCTASE__45__NADPH__45__RXN" name="Nitrate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nit-3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrate reductase subunit )</html:p>
<html:p>SUBSYSTEM: nitrate reduction V (assimilatory)</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2982" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ilr1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indole-3-acetyl-leu hydrolase )</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: LEU</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__ACETYL__45__LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LEU" stoichiometry="1"/>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFATE__45__ADENYLYLTRANS__45__RXN" name="Sulfate adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( sat ) or ( cysD and cysN ) or ( met3 ) or (  ) or ( APS2 ) or ( sat ) or ( APS4 ) or ( APS3 ) or ( APS1 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP sulfurylase asubunit ) or ( CysD and CysN ) or ( Met3 ) or ( NA ) or ( ASA1 ) or ( ATP sulfurylase subunit ) or ( APS4 ) or ( APS3 ) or ( APS1 ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur metabolism (Desulfocapsa sulfoexigens)</html:p>
<html:p>SUBSYSTEM: sulfate reduction I (assimilatory)</html:p>
<html:p>SUBSYSTEM: sulfate reduction IV (dissimilatory)</html:p>
<html:p>SUBSYSTEM: sulfate reduction II (assimilatory)</html:p>
<html:p>SUBSYSTEM: sulfite oxidation III</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (by sulfhydrylation)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: sulfate reduction III (dissimilatory)</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>SUBSYSTEM: superpathway of thiosulfate metabolism (Desulfovibrio sulfodismutans)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.4</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__83__45__RXN" name="3,7-dimethylquercetin 4&apos;-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methylquercetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.83</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_345__45__TRIHYDROXY__45__37__45__DIMETHOXYFLAVONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10510" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3562" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( pIFRalf1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: Superpathway of formononetin derivative biosynthesis</html:p>
<html:p>SUBSYSTEM: medicarpin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.45</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXYFORMONONETIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3401" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__5__46__1__46__2__45__RXN" name="3-carboxy-cis,cis-muconate cycloisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcaB2 ) or ( pcaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-carboxymuconate lactonizing enzyme type 2 ) or ( subunit of 3-carboxymuconate cycloisomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: aromatic compounds degradation via &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation III (aerobic) (via p-cresol)</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__245" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7737" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__113" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox1 ) or ( GA2ox3 ) or ( GA2ox1 ) or ( GA2ox2 ) or ( GA2ox1 ) or ( GA2ox1 ) or ( GA2ox1 ) or ( GA2ox3 ) or ( GA2ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__140" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__236" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__114" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox1 ) or ( GA2ox3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__236" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__251" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9370" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( yqhD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyclic monoterpene primary alcohol oxidoreductase ) or ( NADP-dependent dehydrogenase )</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9976" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9978" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__111" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( KcMS ) or ( OSCBPW ) or ( RsM2 ) or ( RsM1 ) or ( LUP1 ) or ( BgLUS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: mangrove triterpenoid biosynthesis</html:p>
<html:p>SUBSYSTEM: lupeol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__90" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9376" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dhbF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( holo-DhbF )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9993" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9377" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dhbF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( holo-DhbF )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9994" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRIBFAICARPISOM__45__RXN" name="N-(5&apos;-phospho-D-ribosylformimino)-5-amino-1-(5&apos;&apos;-phosphoribosyl)-4- imidazole carboxamide isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hisA ) or ( hisA ) or ( HISN3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9374" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dhbB and dhbF and dhbE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( holo-DhbF and DhbE monomer and DhbB monomer )</html:p>
<html:p>SUBSYSTEM: bacillibactin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: THR</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDROXYBENZOATE" stoichiometry="3"/>
      <speciesReference species="THR" stoichiometry="3"/>
      <speciesReference species="GLY" stoichiometry="3"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9984" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4621" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( anmK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anhydro-N-acetylmuramic acid kinase )</html:p>
<html:p>SUBSYSTEM: 1,6-anhydro-N-acetylmuramic acid recycling</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__882" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__103__45__RXN" name="Sinapoylglucose--sinapoylglucose O-sinapoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sinapoylglucose:sinapoylglucose O-sinapoyltransferase ) or ( sinapoylglucose:sinapoylglucose O-sinapoyltransferase )</html:p>
<html:p>SUBSYSTEM: sinapate ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.103</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__SINAPOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_12__45__BIS__45__O__45__SINAPOYL__45__BETA__45__D__45__GLUCOSIDE" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9369" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( yqhD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyclic monoterpene primary alcohol oxidoreductase ) or ( NADP-dependent dehydrogenase )</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9977" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9978" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXIII__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxalase III monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9368" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyclic monoterpene primary alcohol oxidoreductase and acyclic monoterpene primary alcohol oxidoreductase ) or ( acyclic monoterpene primary alcohol oxidoreductase )</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7857" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9976" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9367" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyclic monoterpene primary alcohol oxidoreductase and acyclic monoterpene primary alcohol oxidoreductase ) or ( acyclic monoterpene primary alcohol oxidoreductase )</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7857" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9977" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__118" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox3 ) or ( GA2ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__204" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__229" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__115" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox1 ) or ( GA2ox2 ) or ( GA2ox3 ) or ( GA2ox1 ) or ( GA2ox2 ) or ( GA2ox1 ) or ( GA2ox1 ) or ( GA2ox1 ) or ( GA2ox3 ) or ( GA2ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.13</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__139" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__204" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3592" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: genistein conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3422" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__3421" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__AMINOTRANSFERASE__45__RXN" name="Tyrosine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( phhC ) or ( TAT ) or (  ) or (  ) or ( aroJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunits of TAT1 ) or ( tyrosine aminotransferase subunit ) or ( tyrosine aminotransferase subunit ) or ( subunit TAT 2 ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation II</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylpyruvate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.5</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTATE__45__DECARBOXYLASE__45__RXN" name="Acetolactate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aldB ) or ( aldB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-acetolactate decarboxylase subunit ) or ( &amp;alpha;-acetolactate decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of butanediol biosynthesis</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.5</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__14__45__RXN" name="Ethanolamine-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( AT2G38670 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-ethanolamine synthase ) or ( CDP-ethanolamine synthase ) or ( ethanolamine-phosphate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylethanolamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.14</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3591" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: daidzein conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3424" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="DAIDZEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3590" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: genistein conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3421" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENOL__45__2__45__MONOOXYGENASE__45__RXN" name="Phenol 2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dmpP and dmpO and mpN and dmpM and dmpL and dmpK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenol hydroxylase P5 component and phenol hydroxylase P3 component and phenol hydroxylase P4 component and phenol hydroxylase P1 component and phenol hydroxylase P2 component and phenol hydroxylase P0 component )</html:p>
<html:p>SUBSYSTEM: phenol degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9380" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nspC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9995" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NORSPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9382" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bar )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.183</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9998" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9999" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__81__45__RXN" name="Threonine-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-threonine-O-3-phosphate decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: aminopropanol phosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.81</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__THREONINE__45__O__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__1__45__AMINOPROPAN__45__2__45__YL__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fkbM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10014" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9384" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( metZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9385" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ftsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Factor__45__420__124__" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10017" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBENZOATE__45__6__45__MONOOXYGENASE__45__RXN" name="3-hydroxybenzoate 6-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: m-cresol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.24</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__633" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENTG__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( entF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__62" stoichiometry="3"/>
      <speciesReference species="SERYL__45__AMP" stoichiometry="3"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="6"/>
      <speciesReference species="ENTEROBACTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1603" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rdgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__130__45__RXN" name="Precorrin-2 C20-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CobI )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.130</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__642" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9387" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hyuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydantoin racemase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10019" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10020" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1602" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rdgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DITP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__121" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ctfB and ctfA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( butyrate-acetoacetate CoA-transferase, subunit A and butyrate-acetoacetate CoA-transferase, subunit B )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SFA1 ) or ( adhI ) or ( frmA ) or ( flhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-(hydroxymethyl)glutathione dehydrogenase subunit ) or ( AdhI ) or ( FrmA ) or ( FlhA )</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.284</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCURONATE__45__REDUCTASE__45__RXN" name="Glucuronate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1a4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1, member A4 (aldehyde reductase) )</html:p>
<html:p>SUBSYSTEM: glucuronate degradation</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis VI</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.19</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GULONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3583" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: genistein conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.115</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3421" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3422" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__8__45__RXN" name="Dimethylaniline monooxygenase (N-oxide forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FMO3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dimethylaniline monooxygenase (n-oxide forming) 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NN__45__DIMETHYLANILINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NN__45__DIMETHYLANILINE__45__N__45__OXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3584" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: daidzein conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.170</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DAIDZEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3424" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R12__45__RXN" name="6-phospho-3-hexuloisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rmpB ) or ( rmpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phspho-3-hexuloisomerase subunit ) or ( 6-phospho-3-hexuloisomerase subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.27</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__26" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3581" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: genistein conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.170</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3421" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD_TO_FADH2_COF_RXN" name="FAD_TO_FADH2_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FADH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3588" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: daidzein conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3425" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__3424" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2961" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.22</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3585" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: daidzein conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.115</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3424" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3425" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7883" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__129" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7202" stoichiometry="1"/>
      <speciesReference species="CPD__45__7204" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7884" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__119" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7202" stoichiometry="1"/>
      <speciesReference species="CPD__45__7200" stoichiometry="1"/>
      <speciesReference species="CPD__45__7199" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7885" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__130" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7200" stoichiometry="2"/>
      <speciesReference species="CPD__45__7202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7886" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__133" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7202" stoichiometry="1"/>
      <speciesReference species="CPD__45__7203" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYQUINOL__45__12__45__DIOXYGENASE__45__RXN" name="Hydroxyquinol 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( npcC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrophenol degradation II</html:p>
<html:p>SUBSYSTEM: resorcinol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.37</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8130" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__CISCIS__45__MUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__147" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CrtL-e ) or ( LUT2 ) or ( LCYe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;delta;-carotene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__114" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__115" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__148" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CrtL-b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lutein biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__115" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__118" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALADENOSYLTRANS__45__RXN" name="Cob(I)alamin adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)yrinic acid a,c-diamide adenosyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COB__45__I__45__ALAMIN" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__3__46__1__45__RXN" name="Methylmalonyl-CoA carboxyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonyl-CoA carboxyltransferase 12S subunit and methylmalonyl-CoA carboxyltransferase 1.3S biotinyl subunit and methylmalonyl-CoA carboxyltransferase 5S subunit )</html:p>
<html:p>SUBSYSTEM: glutamate degradation VIII (to propionate)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.1</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: PROPIONYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__151" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CrtL-b ) or ( LYC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-carotene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__126" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__129" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__150" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CrtL-b ) or ( LYC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-carotene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__114" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__126" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HYD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4081" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4101" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1483" name="Ferroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ftnA ) or ( cueO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferritin iron storage protein ) or ( multicopper oxidase with role in copper homeostasis )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.16.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FE__43__2" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FE__43__3" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__82__45__RXN" name="Phosphonopyruvate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fom2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fosfomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.82</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__235" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__551" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7892" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7197" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7203" stoichiometry="1"/>
      <speciesReference species="CPD__45__7202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDAZOLONEPROPIONASE__45__RXN" name="Imidazolonepropionase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( hutI ) or ( hutI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: histidine degradation I</html:p>
<html:p>SUBSYSTEM: histidine degradation II</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>SUBSYSTEM: histidine degradation VI</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.7</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMIMINO__45__L__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7891" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7196" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7197" stoichiometry="1"/>
      <speciesReference species="CPD__45__7203" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__863" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bssC and bssA and bssB ) or ( bssA and bssB and bssC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzylsuccinate synthase &amp;beta; subunit and benzylsuccinate synthase &amp;gamma; subunit and benzylsuccinate synthase &amp;alpha; subunit ) or ( benzylsuccinate synthase &amp;gamma; subunit and benzylsuccinate synthase &amp;beta; subunit and benzylsuccinate synthase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoyl-CoA (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.1.99.11</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="TOLUENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZYLSUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPHOSPHOR__45__RXN" name="Guanosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7895" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7198" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7201" stoichiometry="1"/>
      <speciesReference species="CPD__45__7202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__864" name="Succinyl-CoA:(R)-benzylsuccinate CoA-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bbsF and bbsE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl-CoA:benzylsuccinate CoA-transferase BbsE subunit and succinyl-CoA:benzylsuccinate CoA-transferase BbsF subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoyl-CoA (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.15</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
      <speciesReference species="BENZYLSUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZYLSUCCINYL__45__COA" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__865" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bbsG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzylsuccinyl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoyl-CoA (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZYLSUCCINYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__PHENYLITACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__PHYT__45__RXN" name="6-phytase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( appA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AppA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phytate degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.26</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MI__45__PENTAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7893" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7424" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7197" stoichiometry="1"/>
      <speciesReference species="CPD__45__7201" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7894" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7424" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7198" stoichiometry="1"/>
      <speciesReference species="CPD__45__7203" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP__45__6__45__DEOXY__45__D__45__TALOSE__45__4__45__DEHYDROGENASE__45__RXN" name="GDP-6-deoxy-D-talose 4-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tld )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: GDP-6-deoxy-D-talose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.135</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__354" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7897" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7206" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7207" stoichiometry="1"/>
      <speciesReference species="CPD__45__7204" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCLOHEXANONE__45__MONOOXYGENASE__45__RXN" name="Cyclohexanone monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( chnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cyclohexanol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.22</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYCLOHEXANONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__101" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate synthetase )</html:p>
<html:p>SUBSYSTEM: canavanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROGENASE__45__NADPORNOP__43____45__RXN" name="Alcohol dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yqhD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__151__45__RXN" name="Benzophenone synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydroxyxanthone biosynthesis (from 3-hydroxybenzoate)</html:p>
<html:p>SUBSYSTEM: superpathway of tetrahydroxyxanthone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.151</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__264" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2346__45__TETRAHYDROXYBENZOPHENONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALAMINSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobV ) or ( cobS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosyl-cobalamin (5&apos;-phosphate) synthase ) or ( CobS )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.26</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__RIBAZOLE" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__98__46__1__45__RXN" name="CoB--CoM heterodisulfide reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mvhD and hdrC and mvhG and mvhA and hdrB and hdrA ) or (  ) or ( hdrD and hdrE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydrogenase &amp;delta; subunit and heterodisulfide &amp;alpha; subunit and heterodisulfide reductase &amp;gamma; subunit and heterodisulfide reductase &amp;beta; subunit and hydrogenase &amp;gamma; subunit and hydrogenase &amp;alpha; subunit ) or (  ) or ( HdrD and cytochrome b subunit )</html:p>
<html:p>SUBSYSTEM: coenzyme B/coenzyme M regeneration</html:p>
<html:p>PROTEIN_CLASS: 1.8.98.1</html:p>
<html:p>SIDE: __124__CoM__124__</html:p>
<html:p>SIDE: CPD__45__1281</html:p>
<html:p>SIDE: CPD__45__1282</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1282" stoichiometry="1"/>
      <speciesReference species="DIHYDROMETHANOPHENAZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1281" stoichiometry="1"/>
      <speciesReference species="CPD__45__7323" stoichiometry="1"/>
      <speciesReference species="__124__CoM__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLMETHANOFURAN__45__DEHYDROGENASE__45__RXN" name="Formylmethanofuran dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fwdC and fwdB and fwdA and fwdD ) or ( fmdC and fmdB and fwdA ) or ( fmdA and fmdC and fmdB and fmdE and fmdD and fmdF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FwdB protein and FwdC protein and FwdA protein and FwdD protein ) or ( FmdB protein and FmdC protein and FwdA protein ) or ( FmdB and FmdC and FmdA and FmdE and FmdD and FmdF )</html:p>
<html:p>SUBSYSTEM: methyl-coenzyme M oxidation to CO2</html:p>
<html:p>SUBSYSTEM: methanogenesis from CO2</html:p>
<html:p>PROTEIN_CLASS: 1.2.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Formyl__45__methanofurans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Methanofurans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__19__45__RXN" name="Trimethylsulfonium--tetrahydrofolate N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.19</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CPD__45__7670</html:p>
<html:p>SIDE: TRIMETHYLSULFONIUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7670" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRIMETHYLSULFONIUM" stoichiometry="1"/>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__167" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox1D ) or ( GA20ox ) or ( GA20ox ) or ( GA20ox3 ) or ( GA20ox2 ) or ( SD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis III (early C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CPD__45__10332</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__695" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10332" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__168" name="gibberellin-44 dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox1D ) or ( GA20ox ) or ( GA20ox ) or ( GA20ox2 ) or ( SD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis III (early C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.12</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__638" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__96" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__165" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox2 ) or ( GA3ox1 ) or ( GA3ox1 ) or ( GA3ox3 ) or ( GA3ox2-1 ) or ( GA3ox1 ) or ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( gibberellin 3-oxidase ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__134" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__137" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__166" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__137" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__139" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__169" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox1D ) or ( GA20ox ) or ( GA20ox2 ) or ( SD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( gibberellin 20-oxidase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis III (early C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__96" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__140" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DARABALDOL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fucA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__RIBULOSE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__170" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox2 ) or ( GA3ox4 ) or ( GA3ox1 ) or ( GA3ox1 ) or ( GA3ox2-1 ) or ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( gibberellin 3-oxidase ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis III (early C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.15</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__140" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__139" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4141" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 50-kDa subunit and 70-kDa subunit )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;alpha;-oxidation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2R__45__HYDROPEROXY__45__FATTY__45__ACIDS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2R__45__HYDROXY__45__FATTY__45__ACIDS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPC__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DCD dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: 4-toluenecarboxylate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__14__45__DICARBOXY__45__35__45__CYCLOHEXDIENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__99__46__25__45__RXN" name="Quinate dehydrogenase (pyrroloquinoline-quinone)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( quiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( quinate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: quinate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.25</html:p>
<html:p>COFACTOR: PQQ</html:p>
<html:p>COFACTOR: CPD__45__104</html:p>
<html:p>SIDE: PQQ</html:p>
<html:p>SIDE: CPD__45__104</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROQUINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__155" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NSY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: abscisic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__133" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__135" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4144" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATE__45__REDUCTASE__45__NADH__45__RXN" name="nitrate reductase (NADH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NIA1 ) or ( NIA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrate reductase 1 subunit ) or ( nitrate reductase 2 subunit )</html:p>
<html:p>SUBSYSTEM: nitrate reduction II (assimilatory)</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ilvE ) or ( ilvE ) or ( ilvE ) or ( ilvE ) or ( BAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase subunit ) or ( branched-chain-amino-acid aminotransferase subunit ) or ( IlvE ) or ( branched-chain-amino-acid aminotransferase subunit ) or ( branched-chain amino acid aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis V</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I (from threonine)</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( ALD2 ) or ( ALDH2 ) or ( ALD4 ) or ( ALD5 ) or ( alkH ) or ( ALD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 50-kDa subunit and 70-kDa subunit ) or ( NA ) or ( aldehyde dehydrogenase class 2 subunit ) or ( potassium-activated aldehyde dehydrogenase, mitochondrial ) or ( aldehyde dehydrogenase, mitochondrial ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;omega;-oxidation</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;alpha;-oxidation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="P__45__COUMAROYL__45__COA_TO_CO__45__A_COF_RXN" name="P-COUMAROYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="P__45__COUMAROYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__160" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-1 ) or ( KAO1 ) or ( KAO1 ) or ( KAO2 ) or ( KAO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>SUBSYSTEM: superpathway of GA12 biosynthesis</html:p>
<html:p>SUBSYSTEM: GA12 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__136" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__138" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__162" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox1D ) or ( GA20ox ) or ( GA20ox2 ) or ( GA20ox ) or ( GA20ox1 ) or ( GA20ox3 ) or ( GA20ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__95" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__97" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-1 ) or ( KAO1 ) or ( KAO1 ) or ( KAO2 ) or ( KAO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>SUBSYSTEM: superpathway of GA12 biosynthesis</html:p>
<html:p>SUBSYSTEM: GA12 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__138" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__95" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__164" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox4 ) or ( GA20ox1D ) or ( GA20ox ) or ( GA20ox2 ) or ( GA20ox1 ) or ( GA20ox3 ) or ( GA20ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 20-oxidase ) or ( NA ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__120" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__134" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__167__45__RXN" name="10-deacetylbaccatin III 10-O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DBAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: taxol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.167</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_10__45__DEACETYLBACCATIN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BACCATIN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox1D ) or ( GA20ox ) or ( GA20ox2 ) or ( GA20ox ) or ( GA20ox1 ) or ( GA20ox3 ) or ( GA20ox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__97" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__120" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHUROPORDEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cysG ) or ( cysG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CysG ) or ( uroporphyrinogen-III C-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.76</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTPDECARB__45__RXN" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pyrF ) or ( AT3G54470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PyrF ) or ( UMP synthase )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.23</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYBUTYRATE__45__DEHYDROGENASE__45__RXN" name="4-hydroxybutyrate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 4hbD ) or ( Msed_1424 ) or ( abfH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybutyrate dehydrogenase (NAD) ) or ( succinate semialdehyde reductase (NADPH) ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: succinate fermentation to butyrate</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.61</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXAL__45__4__45__DEHYDROGENASE__45__RXN" name="Pyridoxal 4-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pldh-t )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal 4-dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: vitamin B6 degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.107</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__375" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROT__45__RXN" name="Dihydroorotase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pyrC ) or ( CAD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PyrC ) or ( CAD protein )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5641" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BnSDC ) or ( AtSDC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( serine decarboxylase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHD__45__RXN" name="Choline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( betA ) or ( betA ) or ( betA ) or ( betA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: choline degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis I (Gram-negative bacteria)</html:p>
<html:p>SUBSYSTEM: choline-O-sulfate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__299" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tauD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( taurine dioxygenase monomer )</html:p>
<html:p>SUBSYSTEM: taurine degradation IV</html:p>
<html:p>SUBSYSTEM: superpathway of taurine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.17</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1772" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__101" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 20-oxidase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis III (early C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__96" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__86" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5642" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LOC_Os01g50030.1 ) or ( AT1G73600 ) or ( NMT 1 ) or ( PEAMT ) or ( AT1G48600 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoethanolamine N-methyltransferase, putative, expressed ) or ( phosphoethanolamine N-methyltransferase ) or ( NA ) or ( NA ) or ( phosphoethanolamine N-methyltransferase ) or ( phosphoethanolamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.103</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__406" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5441" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5643" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LOC_Os01g50030.1 ) or ( AT1G73600 ) or ( NMT 1 ) or ( PEAMT ) or ( AT1G48600 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoethanolamine N-methyltransferase, putative, expressed ) or ( phosphoethanolamine N-methyltransferase ) or ( NA ) or ( NA ) or ( phosphoethanolamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.103</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R222__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( alkH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: octane oxidation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__371" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__N__45__CHOLOYLTRANSFERASE__45__RXN" name="Glycine N-choloyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Baat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bile acid-CoA:amino acid N-acyltransferase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.65</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="GLYCOCHOLIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5647" name="phosphoethanolamine/phosphocholine phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of choline biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.75</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R281__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aliA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AliA )</html:p>
<html:p>SUBSYSTEM: cyclohexane-1-carboxylate degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__575" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__577" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7843" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pGAT4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.153</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7137" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7151" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CHMT_MEDSA  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.154</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3361" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7842" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pGAT4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.153</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CAFFEOYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7137" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7150" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__31__45__RXN" name="Aminoadipate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha; aminoadipate reductase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.31</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7082" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Glu1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-glucosidase )</html:p>
<html:p>SUBSYSTEM: DIMBOA-glucoside degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6562" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__6366" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BENZOATE__45__12__45__DIOXYGENASE__45__RXN" name="Benzoate 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylY and xylZ and xylX ) or ( benA and benB and benC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( XylX and XylY and XylZ ) or ( benzoate 1,2-dioxygenase electron transfer subunit and benzoate 1,2-dioxygenase hydroxylase &amp;alpha: subunit and benzoate 1,2-dioxygenase hydroxylase &amp;beta: subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: benzoate degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation IV (aerobic) (via catechol)</html:p>
<html:p>SUBSYSTEM: meta cleavage pathway of aromatic compounds</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.10</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__290" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__54__45__RXN" name="Precorrin-6X reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.54</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__675" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__679" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__SYN__45__RXN" name="glutathione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSS ) or ( GSH2 ) or ( gsa1 ) or ( gshB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione synthetase subunit ) or ( GSH2 subunit ) or ( glutathione synthetase small subunit and glutathione synthetase large subunit ) or ( glutathione synthetase subunit )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1441" name="ADP-ribose pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nudF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP- sugar pyrophosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE_DIPHOSPHATE_RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDOTRANS2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( waaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: KDO transfer to lipid IVA</html:p>
<html:p>PROTEIN_CLASS: 2.-.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP__45__KDO" stoichiometry="1"/>
      <speciesReference species="KDO__45__LIPID__45__IVA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO2__45__LIPID__45__IVA" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__91__45__RXN" name="Sinapoylglucose--choline O-sinapoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SNG2 ) or ( BnSCT ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sinapate ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.91</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: CHOLINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__SINAPOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SINAPOYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__100__45__RXN" name="Protein-S isoprenylcysteine O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( STE14B ) or ( STE14A )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.100</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__ETC__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__FARNESYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4122" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;alpha;-oxidation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2R__45__HYDROPEROXY__45__FATTY__45__ACIDS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7859" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: cannabinoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7171" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7174" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLALANINE__45__4__45__MONOOXYGENASE__45__RXN" name="Phenylalanine 4-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAH ) or ( phhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylalanine hydroxylase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.1</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R312__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: aldoxime degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPYRIDALDOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__CYANOPYRIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7858" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: cannabinoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7170" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7173" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4121" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 50-kDa subunit and 70-kDa subunit ) or ( fatty acid &amp;alpha;-dioxygenase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;alpha;-oxidation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.-</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2R__45__HYDROPEROXY__45__FATTY__45__ACIDS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7857" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: cannabinoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7169" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7172" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA__45__OXIDASE__45__RXN" name="Acyl-CoA oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4G16760 ) or ( AT3G51840 ) or ( AT5G65110 ) or ( AT1G06290 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA oxidase ) or ( NA ) or ( acyl-CoA oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7856" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CBCA synthase subunit )</html:p>
<html:p>SUBSYSTEM: cannabinoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.-</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCULOKIN__45__RXN" name="L-fuculokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fucK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-fuculokinase )</html:p>
<html:p>SUBSYSTEM: fucose degradation</html:p>
<html:p>SUBSYSTEM: superpathway of fucose and rhamnose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.51</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__FUCULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUCULOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATE__45__BUTYRYLTRANSFERASE__45__RXN" name="Phosphate butyryltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ptb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphotransbutyrylase subunit )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate I</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.19</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRYL__45__P" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7855" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cannabinoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7170" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7854" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( THCA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cannabinoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.-</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7169" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7853" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cannabinoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: GERANYL__45__PP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7165" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R__45__6__45__HYDROXYNICOTINE__45__OXIDASE__45__RXN" name="(R)-6-hydroxynicotine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 6-hdno )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: nicotine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__6__45__HYDROXYNICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__280" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ssuD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SsuD )</html:p>
<html:p>SUBSYSTEM: two-component alkanesulfonate monooxygenase</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.5</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alkanesulfonates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DADP_TO_DATP_COF_RXN" name="DADP_TO_DATP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="DADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__68__45__RXN" name="4-hydroxyphenylacetaldehyde oxime monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cyp71E1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dhurrin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.68</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__648" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__276" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SFA1 ) or ( adhI ) or ( frmA ) or ( flhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-(hydroxymethyl)glutathione dehydrogenase subunit ) or ( AdhI ) or ( FrmA ) or ( FlhA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.-.-.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__3__46__20__45__RXN" name="ADP-glyceromanno-heptose 6-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-L-glycero-D-mannoheptose-6-epimerase )</html:p>
<html:p>SUBSYSTEM: ADP-L-glycero-&amp;beta;-D-manno-heptose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__D__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__279" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( csdE and csdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CsdE and NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="SULFUR__45__DIOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2ASDOSALCAL__45__RXN" name="2-aminobenzenesulfonate 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( orthanilate dioxygenase system, oxygenase component and orthanilate dioxygenase system, reductase component )</html:p>
<html:p>SUBSYSTEM: orthanilate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINOBENZENESULFONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFOCATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7868" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CBCA synthase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7175" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__275" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hyuA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylhydantoinase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLHYDANTOIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8524" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__9__45__CYTOKININ__45__ALANINE__45__SYNTHASE__45__RXN" name="&amp;beta;-(9-cytokinin)-alanine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lupinate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.50</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: ACETYLSERINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__669" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7866" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7175" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7170" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7860" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cannabinoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: CPD__45__461</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7165" stoichiometry="1"/>
      <speciesReference species="CPD__45__461" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7175" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__SUCCINYLBENZOATE__45__COA__45__LIG__45__RXN" name="O-succinylbenzoate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( menE ) or ( menE ) or ( menE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( MenE ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.26</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__SUCCINYLBENZOATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6972" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__143__45__RXN" name="24-methylenesterol C-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AF042332 ) or ( SMT2 ) or ( OJ1119_B04.1 ) or ( SMT3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 24-methylenesterol C-methyltransferase ) or ( sterol methyltransferase ) or ( 24-methylenesterol C-methyltransferase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.143</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4101" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4124" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7061" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: benzoxazinoid glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6562" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6561" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7062" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CaUGT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: curcumin glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6602" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6622" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7063" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CaUGT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: curcumin glucoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6622" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6623" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1461" name="Coproporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hemF ) or ( hemF ) or ( CPO ) or ( HEMF1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( coproporphyrinogen III oxidase subunit ) or ( coproporphyrinogen III oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen II</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MTDMBARK__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mtd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mtd )</html:p>
<html:p>SUBSYSTEM: methyl-coenzyme M oxidation to CO2</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.-</html:p>
<html:p>SIDE: __124__Reduced__45__Factor__45__F420__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10" stoichiometry="1"/>
      <speciesReference species="__124__Oxidized__45__Factor__45__F420__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__11" stoichiometry="1"/>
      <speciesReference species="__124__Reduced__45__Factor__45__F420__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVFORMLY__45__RXN" name="Formate C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pflB ) or ( pfl ) or ( tdcE ) or ( pfl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PflB ) or ( pyruvate formate-lyase subunit ) or ( NA ) or ( pyruvate formate-lyase subunit )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: reductive monocarboxylic acid cycle</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate IV</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to ethanol I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.54</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ARABINONATE__45__DEHYDRATASE__45__RXN" name="L-arabinonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( araC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-arabonate dehydratase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1117" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1134" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__268" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( scpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: conversion of succinate to propionate</html:p>
<html:p>SUBSYSTEM: glutamate degradation VIII (to propionate)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>SIDE: PROPIONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3SC23OALCAL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: orthanilate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFOCATECHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8218" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__262" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mobA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: molybdopterin guanine dinucleotide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="CPD__45__8123" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__582" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__37" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase class 2 subunit )</html:p>
<html:p>SUBSYSTEM: putrescine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__30" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__35" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__34" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: canavanine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7878" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid 22&amp;alpha;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7193" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7192" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__35" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( canaline reductase )</html:p>
<html:p>SUBSYSTEM: canavanine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.6.6.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7877" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid 22&amp;alpha;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4127" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7191" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7876" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid 22&amp;alpha;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4143" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7875" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid 22&amp;alpha;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7189" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1603" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__409" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__504" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__886" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__638" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__885" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9194" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: geranyl acetate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9758" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="GERANIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__94__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vindoline and vinblastine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.94</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_16__45__HYDROXYTABERSONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7164" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DMBPPRIBOSYLTRANS__45__RXN" name="Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobT ) or ( cobU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase subunit ) or ( nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.21</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NIACINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
      <speciesReference species="DIMETHYLBENZIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__RIBAZOLE__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ilvG_1 and ilvG_2 and ilvM ) or ( ilvN and ilvB ) or ( ilvH and ilvI ) or ( ilvB and ilvN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IlvM and acetolactate synthase II, large subunit, C-ter fragment (pseudogene) and acetolactate synthase II, large subunit, N-ter fragment (pseudogene) ) or ( IlvN and IlvB ) or ( IlvH and IlvI ) or ( acetohydroxy-acid synthase large subunit and acetohydroxy-acid synthase small subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I (from threonine)</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9190" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( menA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: menaquinone-7 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DIHYDROXYNAPHTHOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9731" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE_TO_L__45__ALPHA__45__ALANINE_COF_RXN" name="PYRUVATE_TO_L-ALPHA-ALANINE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9191" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( menH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: menaquinone-7 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9731" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9718" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9192" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RhAAT1 ) or ( AAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: geranyl acetate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9758" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__82__45__RXN" name="Pheophorbidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PPD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll a degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.82</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: METOH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7061" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__10296" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9193" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: geraniol and geranial biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANIAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9762" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Donor__45__H2__124___TO___124__Acceptor__124___COF_RXN" name="|Donor-H2|_TO_|Acceptor|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__6__45__HYDROXYNICOTINE__45__OXIDASE__45__RXN" name="(S)-6-hydroxynicotine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 6-hlno )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-Hlno )</html:p>
<html:p>SUBSYSTEM: nicotine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.5</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__125" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8540" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Lon ) or ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>SUBSYSTEM: oleoresin sesquiterpene volatiles biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8701" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8541" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>SUBSYSTEM: oleoresin sesquiterpene volatiles biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8730" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOHEMEFERROCHELAT__45__RXN" name="Ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hemH ) or ( hemH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen II</html:p>
<html:p>SUBSYSTEM: heme biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYROXALTRANSAM__45__RXN" name="Pyridoxamine--oxaloacetate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.31</html:p>
<html:p>COFACTOR: OXALACETIC_ACID</html:p>
<html:p>COFACTOR: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOHMETRANS__45__RXN" name="glycine hydroxymethyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( glyA ) or ( glyA1 ) or ( glyA ) or ( SHM2 ) or ( glyA ) or ( glyA ) or ( SHM1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase ) or ( NA ) or ( serine hydroxymethyltransferase subunit ) or ( serine hydroxymethyltransferase 1 subunit ) or ( serine hydroxymethyltransferase ) or ( serine hydroxymethyltransferase, cytosolic ) or ( NA ) or ( GlyA ) or ( serine hydroxymethyltransferase, mitochondrial ) or ( serine hydroxymethyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: photorespiration</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.1</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7042" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AF216282 ) or ( AF216283 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis IV (from glycine)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.157</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8538" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP720B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abietadienol/abietadienal oxidase )</html:p>
<html:p>SUBSYSTEM: isopimaric acid biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8728" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8729" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8537" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: isopimaric acid biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8727" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8728" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8536" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP720B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abietadienol/abietadienal oxidase )</html:p>
<html:p>SUBSYSTEM: isopimaric acid biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8726" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8727" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7800" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8534" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP720B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abietadienol/abietadienal oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: dehydroabietic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8724" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7801" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: __124__Sterols__124__</html:p>
<html:p>SIDE: __124__O__45__Glucosylsterols__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__O__45__Glucosylsterols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Glucosyl__45__Ceramides__124__" stoichiometry="1"/>
      <speciesReference species="__124__Sterols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8533" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: dehydroabietic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8723" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8724" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8532" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP720B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abietadienol/abietadienal oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: dehydroabietic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8722" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8723" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOLALD__45__DEHYDROG__45__RXN" name="Glycolaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aldA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AldA )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of glycol metabolism and degradation</html:p>
<html:p>SUBSYSTEM: ethylene glycol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.21</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7805" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VPS ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phlorisovalerophenone synthase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cohumulone biosynthesis</html:p>
<html:p>SUBSYSTEM: hyperforin biosynthesis</html:p>
<html:p>SUBSYSTEM: bitter acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.156</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7104" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5682" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TyrAAT2 ) or ( TyrAAT1 ) or ( tyrAa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arogenate dehydrogenase ) or ( NA ) or ( arogenate dehydrogenase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine and tyrosine biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.43</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__659" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7807" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: humulone biosynthesis</html:p>
<html:p>SUBSYSTEM: bitter acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7105" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7106" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8550" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Bis ) or ( f-E&amp;alpha;bis ) or ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (E)-&amp;alpha-bisabolene synthase ) or ( (E)-&amp;alpha;-bisabolene synthase ) or ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>SUBSYSTEM: oleoresin sesquiterpene volatiles biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8738" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8552" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LTC1 ) or ( CiGASlo ) or ( LTC2 ) or ( GAS ) or ( CiGASsh ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( germacrene A synthase ) or ( germacrene A synthase ) or ( NA ) or ( germacrene A synthase ) or ( germacrene A synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: germacrene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8743" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8547" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Car ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-carene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8736" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8546" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Car ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-carene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8735" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8549" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8737" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R210__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__151" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8548" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8739" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8543" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8732" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LAT1 ) or ( LAT2 ) or ( AT3G11430 ) or (  ) or ( plsC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( 1-acylglycerol-3-phosphate O-acyltransferase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.51</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8542" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8731" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7810" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: humulone biosynthesis</html:p>
<html:p>SUBSYSTEM: bitter acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__7109" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7105" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA__45__CARBOXYLTRANSFER__45__RXN" name="Acetyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( accD and accB and accA and accC ) or ( ATCG00500 and At5g35360 and At2g38040 and At5g16390 ) or ( Msed_1375 and Msed_0147 and Msed_0148 ) or ( accA3 ) or ( pccB and accC and accB ) or ( accD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotinylated biotin-carboxyl carrier protein and AccD and AccA and AccC ) or ( carboxyltransferase &amp;beta; subunit and biotin carboxylase and carboxyltransferase &amp;alpha; subunit and biotin carboxyl carrier protein ) or ( acyl CoA carboxylase biotin carboxyl carrier protein subunit and acyl CoA carboxylase biotin carboxylase subunit and acyl CoA carboxylase carboxyltransferase subunit ) or ( acetyl/propionyl-coa carboxylase alpha chain ) or ( acyl CoA carboxylase carboxyltransferase subunit and acyl CoA carboxylase biotin carboxyl carrier protein subunit and acyl CoA carboxylase biotin carboxylase subunit ) or ( Probable acetyl-coenzyme a carboxylase beta subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis initiation (E. coli)</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis I (E. coli)</html:p>
<html:p>SUBSYSTEM: fatty acid biosynthesis initiation I</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate assimilation</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis II (plant)</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8545" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8734" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7811" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: humulone biosynthesis</html:p>
<html:p>SUBSYSTEM: bitter acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="_3__45__METHYL__45__1__45__246__45__TRIHYDROXYPHENYLBUTAN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7109" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8544" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8733" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ilvE ) or ( ilvE ) or ( ilvE ) or ( BAT1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase subunit ) or ( IlvE ) or ( branched-chain-amino-acid aminotransferase subunit ) or ( branched-chain amino acid aminotransferase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7812" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cohumulone biosynthesis</html:p>
<html:p>SUBSYSTEM: hyperforin biosynthesis</html:p>
<html:p>SUBSYSTEM: bitter acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="CPD__45__7104" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__PRENYLPHLORISOBUTYROPHENONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7813" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cohumulone biosynthesis</html:p>
<html:p>SUBSYSTEM: hyperforin biosynthesis</html:p>
<html:p>SUBSYSTEM: bitter acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CPD__45__4211</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__PRENYLPHLORISOBUTYROPHENONE" stoichiometry="1"/>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7107" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7815" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( D85186 ) or ( pGUT8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: anthocyanin biosynthesis (delphinidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.115</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7090" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7117" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OPPSYN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ispB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7022" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Bx9 ) or ( Bx8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: benzoxazinoid glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6366" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6562" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Bx8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: benzoxazinoid glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6365" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6563" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8562" name="Germacradienol synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sc19 ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: germacrene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.22</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8746" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8563" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Pin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8754" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8560" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8753" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8561" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( germacrene C synthase ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( germacrene C synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: germacrene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8745" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__90__45__RXN" name="&amp;beta;-glucogallin O-galloyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: pentagalloylglucose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.90</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__O6__45__O__45__DIGALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8556" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8749" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8555" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8748" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8554" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8747" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8553" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;delta;sel1 ) or ( SSTLH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;delta;-selinene synthase ) or ( germacrene B synthase )</html:p>
<html:p>SUBSYSTEM: germacrene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8744" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INDOLE__45__3__45__ACETALDEHYDE__45__OXIDASE__45__RXN" name="Indole-3-acetaldehyde oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AAO1 ) or (  ) or ( AAO3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AO1 ) or ( indolepyruvate decarboxylase subunit a and indolepyruvate decarboxylase subunit b and indolepyruvate decarboxylase subunit c ) or ( abscisic aldehyde oxidase subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VII (via indole-3-pyruvate)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VI (via tryptamine)</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.7</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8559" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Lon ) or ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8752" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LCYSDESULF__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tnaA ) or ( cdl ) or ( metC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TnaA ) or ( NA ) or ( MetC ) or ( L-cysteine desulfhydrase )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8558" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Lon ) or ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8751" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8557" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8750" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7828" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HGT8 ) or ( PF3R4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvianin biosynthesis</html:p>
<html:p>SUBSYSTEM: pelargonidin conjugates biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PELARGONIDIN__45__3__45__GLUCOSIDE__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7137" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7826" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHS ) or ( VPS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( phlorisovalerophenone synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7147" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DAPASYN__45__RXN" name="Adenosylmethionine--8-amino-7-oxononanoate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bioA ) or (  ) or ( bioA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosylmethionine-8-amino-7-oxononanoate aminotransferase monomer ) or ( NA ) or ( BioA )</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis III</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis II</html:p>
<html:p>SUBSYSTEM: biotin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.62</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_8__45__AMINO__45__7__45__OXONONANOATE" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYL__45__4__45__METHYLTHIO__45__2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="DIAMINONONANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7825" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHS ) or ( VPS ) or ( CHS2 ) or ( CHS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( phlorisovalerophenone synthase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7146" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITROUS__45__OXIDE__45__REDUCTASE__45__RXN" name="Nitrous-oxide reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nosZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrous oxide reductase subunit )</html:p>
<html:p>SUBSYSTEM: nitrate reduction I (denitrification)</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.6</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITROUS__45__OXIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIPHENYL__45__23__45__DIOL__45__12__45__DIOXYGENASE__45__RXN" name="Biphenyl-2,3-diol 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bphC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-dihydroxybiphenyl 1,2-dioxygenase )</html:p>
<html:p>SUBSYSTEM: biphenyl degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.39</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIPHENYL__45__23__45__DIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8570" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Lin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( linalool synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7984" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8571" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Lon )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8761" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8572" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Lon ) or ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>SUBSYSTEM: oleoresin sesquiterpene volatiles biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8762" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8573" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Lon ) or ( f-&amp;gamma;hum )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;gamma;-humulene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8763" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8574" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Far ) or ( eafar ) or ( AFS1 ) or ( afs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( (E,E)-&amp;alpha;-farnesene synthase )</html:p>
<html:p>SUBSYSTEM: farnesene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8764" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8565" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Car ) or ( TPS-Lin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-carene synthase ) or ( linalool synthase )</html:p>
<html:p>SUBSYSTEM: oleoresin monoterpene volatiles biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8756" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8564" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Pin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8755" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7832" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: pelargonidin conjugates biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.116</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7144" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7148" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8567" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__8651</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7650" stoichiometry="1"/>
      <speciesReference species="CPD__45__8651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8757" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8566" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of oleoresin turpentine biosynthesis</html:p>
<html:p>SUBSYSTEM: oleoresin sesquiterpene volatiles biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8758" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7834" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dv3MaT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: pelargonidin conjugates biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.171</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PELARGONIDIN__45__3__45__GLUCOSIDE__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7149" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__143__45__RXN" name="&amp;beta;-glucogallin--tetrakisgalloylglucose O-galloyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: pentagalloylglucose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.143</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="_1236__45__TETRAKIS__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="_12346__45__PENTAKIS__45__O__45__GALLOYL__45__BETA__45__D__45__GLUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase subunit )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: LIPOIC__45__ACID</html:p>
<html:p>SIDE: RIBOSE</html:p>
<html:p>SIDE: CPD__45__296</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__296" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOIC__45__ACID" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__763" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8569" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LinS ) or ( TPS-Lin ) or ( TPS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( linalool synthase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7985" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__17__45__RXN" name="L-serine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sdaA ) or ( tdcB ) or ( tdcG ) or (  ) or ( sdaA ) or ( sdaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( TdcB ) or ( L-serine deaminase III ) or ( NA ) or ( L-serine deaminase I ) or ( L-serine deaminase II )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: L-serine degradation</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__2__45__METHYLMALATE__45__DEHYDRATASE__45__RXN" name="(S)-2-methylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( component II and component I )</html:p>
<html:p>SUBSYSTEM: glutamate degradation VIII (to propionate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VI (to pyruvate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.34</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESACONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__CITRAMALATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSGLYPHOS__45__RXN" name="Phosphoglycerate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pgk ) or ( pgk ) or (  ) or (  ) or ( PGK ) or ( pgk ) or ( pgk ) or ( pgk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate kinase subunit ) or ( Pgk ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: glycolysis IV (plant cytosol)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7830" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: pelargonidin conjugates biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PELARGONIDIN__45__3__45__GLUCOSIDE__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7144" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEATE__45__ISOMERASE__45__RXN" name="Maleate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation II</html:p>
<html:p>SUBSYSTEM: nicotinate degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALEATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__3__46__41__45__RXN" name="Xylitol oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( xyoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alditol oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.41</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7835" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__trans__45__4__45__cis__45__dienoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1641" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AT5G13640 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.158</html:p>
<html:p>SIDE: PHOSPHATIDYLCHOLINE</html:p>
<html:p>SIDE: __124__2__45__Lysophosphatidylcholines__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Lysophosphatidylcholines__124__" stoichiometry="1"/>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7836" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( MFP-a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-3, delta2-enoyl-CoA isomerase ) or ( MFP III ) or ( MFP II ) or ( MFP a )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7837" name="Arsenate reductase (azurin)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( asoB and asoA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arsenite oxidase small subunit and arsenite oxidase large subunit ) or ( arsenite oxidase large subunit and arsenite oxidase small subunit )</html:p>
<html:p>SUBSYSTEM: arsonoacetate degradation</html:p>
<html:p>SUBSYSTEM: arsenite oxidation (respiratory)</html:p>
<html:p>PROTEIN_CLASS: 1.20.98.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__763" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARSENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7838" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( MFP-a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MFP I ) or ( MFP III ) or ( MFP II ) or ( MFP a )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cis__45__2__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UREIDOGLYCOLATE__45__HYDROLASE__45__RXN" name="Ureidoglycolate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ureidoglycolate amidohydrolase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation in plants</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate II</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8583" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of benzaldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: m-xylene degradation to m-toluate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8774" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8775" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8582" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of benzaldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: p-xylene degradation to p-toluate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8773" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__TOLUENECARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8581" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzyl alcohol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: p-xylene degradation to p-toluate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__METHYLBENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8773" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7001" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase subunit )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: __124__Purine__45__Ribonucleosides__124__</html:p>
<html:p>SIDE: __124__Purine__45__Bases__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARSENATE" stoichiometry="1"/>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8580" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzyl alcohol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: m-xylene degradation to m-toluate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYLBENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8774" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__4__46__2__45__RXN" name="Inosamine-phosphate amidinotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( strB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.4.2</html:p>
<html:p>SIDE: L__45__ORNITHINE</html:p>
<html:p>SIDE: ARG</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="CPD__45__180" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__7167" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XMPXAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleotidase )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MMUM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT3g25900 ) or ( mmuM ) or ( AT3g63250 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homocysteine S-methyltransferase ) or ( NA ) or ( homocysteine S-methyltransferase )</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: S-methylmethionine cycle</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.10</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="CPD__45__397" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="R462__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( atrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: atrazine degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ACETONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATRAZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETONE" stoichiometry="1"/>
      <speciesReference species="CPD__45__805" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRIC__45__OXIDE__45__REDUCTASE__45__RXN" name="Nitric-oxide reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( norB and norC ) or ( norV ) or ( norZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitric-oxide reductase small subunit and nitric oxide reductase large subunit ) or ( flavorubredoxin ) or ( NA )</html:p>
<html:p>SUBSYSTEM: nitrate reduction I (denitrification)</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRIC__45__OXIDE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITROUS__45__OXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8579" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylA and xylM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH-acceptor-reductase subunit of xylene monooxygenase and hydroxylase subunit of xylene monooxygenase )</html:p>
<html:p>SUBSYSTEM: p-xylene degradation to p-toluate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1422" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__METHYLBENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8578" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylA and xylM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH-acceptor-reductase subunit of xylene monooxygenase and hydroxylase subunit of xylene monooxygenase )</html:p>
<html:p>SUBSYSTEM: m-xylene degradation to m-toluate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="META__45__XYLENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYLBENZYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8594" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8793" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URACIL__45__PRIBOSYLTRANS__45__RXN" name="Uracil phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( upp ) or ( upp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Upp ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMINE__45__SYNTHASE__45__RXN" name="Spermine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SMS ) or ( SMS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermine synthase subunit ) or ( spermine synthase subunit )</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.22</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__3__46__32__45__RXN" name="(S)-stylopine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP719A2 ) or ( CYP719A3 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__CHEILANTHIFOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__STYLOPINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADNUCLEOSID__45__RXN" name="NAD(+) nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.5</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSINE_DIPHOSPHATE_RIBOSE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
      <speciesReference species="ADENOSINE_DIPHOSPHATE_RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__NITROPHENOL__45__2__45__MONOOXYGENASE__45__RXN" name="4-nitrophenol 2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nphA2 and nphA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-nitrophenol hydroxylase component B and 4-nitrophenol hydroxylase component A )</html:p>
<html:p>SUBSYSTEM: 4-nitrophenol degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.29</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__158" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8587" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8786" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPONTPRO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II (from arginine)</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: (5R)-carbapenem biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45____45__OXO__45__ACID__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rocD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8589" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8788" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__89__45__RXN" name="Tetrahydrodipicolinate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ykuQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.89</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__L__45__2__45__AMINO__45__6__45__OXO__45__PIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACID__45__PHOSPHATASE__45__RXN" name="Acid phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aphA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acid phosphatase/phosphotransferase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8598" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( f-&amp;gamma;hum ) or ( f-&amp;delta;sel1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-humulene synthase ) or ( &amp;delta;-selinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8797" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__17__45__RXN" name="3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dos )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphodiesterase, heme-regulated )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__3__45__5__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NUC__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Nicotinate N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trigonelline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.7</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLNICOTINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OXOADIPATE__45__ENOL__45__LACTONASE__45__RXN" name="3-oxoadipate enol-lactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of 3-oxoadipate enol-lactone hydrolase )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: aromatic compounds degradation via &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation III (aerobic) (via p-cresol)</html:p>
<html:p>SUBSYSTEM: catechol degradation to &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: catechol degradation III (ortho-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation II (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.24</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OXOADIPATE__45__ENOL__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETO__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DXPREDISOM__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dxr ) or ( DXR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dxr ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.267</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__C__45__METHYL__45__D__45__ERYTHRITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1685" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HXK2 ) or ( Hxk2 ) or ( HXK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( hexokinase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: starch degradation</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__59__45__RXN" name="L-lysine 6-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( iucD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-lysine 6-monooxygenase subunit )</html:p>
<html:p>SUBSYSTEM: aerobactin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.59</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__265" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIOXYXANFL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( tecA4 and tecA2 and tecA3 and tecA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorobenzene dioxygenase ) or ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit )</html:p>
<html:p>SUBSYSTEM: 1,4-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_14__45__DICHLOROBENZENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_14__45__DICHLOROBENZENE__45__DIHYDRODIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__172__45__RXN" name="Anthocyanin 5-O-glucoside 6&apos;&apos;&apos;-O-malonyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ss5MaT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvianin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.172</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7140" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7141" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MTAMBARKMULTI__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mtaC and mtaB and mtaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MtaC and NA and NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__CoM__124__" stoichiometry="1"/>
      <speciesReference species="METOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Me__45__CoM__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__30__45__RXN" name="Fucose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis II (from L-fucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.30</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__488" stoichiometry="1"/>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9204" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXYNAPHTHOATE" stoichiometry="1"/>
      <speciesReference species="SOLANESYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9733" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9205" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9733" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9720" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9206" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: colchicine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9790" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9789" stoichiometry="1"/>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9207" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: colchicine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9789" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9788" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__156__45__RXN" name="Indolylacetyl-myo-inositol galactosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indol-3-ylacetyl-myo-inositol galactoside synthase )</html:p>
<html:p>SUBSYSTEM: IAA conjugate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.156</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__O__45__INDOL__45__3__45__YLACETYL__45__MYO__45__ETCETERA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GULONOLACTONE__45__OXIDASE__45__RXN" name="L-gulonolactone oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gulo ) or ( Gulo )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gulonolactone (L-) oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis VI</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.8</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__329" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__99__46__5__45__RXN" name="2-aminomuconate deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( nbaF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-aminomuconate deaminase subunit ) or ( 2-aminomuconate deaminase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: nitrobenzene degradation I</html:p>
<html:p>SUBSYSTEM: 2-amino-3-carboxymuconate semialdehyde degradation to 2-oxopentenoate</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation I</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__MUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__246" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THI__45__P__45__SYN__45__RXN" name="Thiamine-phosphate pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( thiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THZ__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INDOLELACTATE__45__DEHYDROGENASE__45__RXN" name="Indole-3-lactate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IV (via indole-3-lactate)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.110</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__241" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PNMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylethanolamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.28</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NOREPINEPHRINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__EPINEPHRINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9210" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: colchicine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9786" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9785" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__OXOCINEOLE__45__DEHYDROGENASE__45__RXN" name="6-oxocineole dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 1,8-cineole degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.51</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__790" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__788" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9212" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cinchona alkaloids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="CPD__45__9848" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUININE" stoichiometry="1"/>
      <speciesReference species="CPD__45__9846" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BSDOSALCAL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( orthanilate dioxygenase system, oxygenase component and orthanilate dioxygenase system, reductase component ) or ( benzenesulfonate dioxygenase system, reductase component and benzenesulfonate dioxygenase system, oxygenase component )</html:p>
<html:p>SUBSYSTEM: benzenesulfonate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZENESULFONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPIDADISACCHARIDESYNTH__45__RXN" name="Lipid-A-disaccharide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lpxB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( LpxB )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-A-precursor biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.182</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BISOHMYR__45__GLUCOSAMINYL__45__1P" stoichiometry="1"/>
      <speciesReference species="OH__45__MYRISTOYL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BISOHMYR__45__GLC" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9211" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cinchona alkaloids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9826" stoichiometry="2"/>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9835" stoichiometry="1"/>
      <speciesReference species="CPD__45__9847" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__80__45__RXN" name="Cysteine-S-conjugate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glutathione-mediated detoxification</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.80</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__Substituted__45__L__45__Cysteines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__S__45__Substituted__45__N__45__Acetyl__45__L__45__Cysteines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4OH2OXOGLUTARALDOL__45__RXN" name="4-hydroxy-2-oxoglutarate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( eda ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Eda ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__4__45__HYDROXY__45__2__45__KETO__45__GLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYGLUCONOKIN__45__RXN" name="2-dehydro-3-deoxygluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kdgK ) or ( kdgK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 2-keto-3-deoxygluconokinase )</html:p>
<html:p>SUBSYSTEM: superpathway of hexuronide and hexuronate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide and D-glucuronate degradation</html:p>
<html:p>SUBSYSTEM: D-galacturonate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.45</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__DEOXY__45__6__45__P__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__20__45__RXN" name="Methylenetetrahydrofolate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( metF ) or ( AtMTHFR-2 ) or (  ) or ( AtMTHFR-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MetF ) or ( MTHFR2 subunit ) or ( 5.,10-methenyltetrahydrofolate reductase subunit ) or ( MTHFR subunit )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.20</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPMANDEHYDRA__45__RXN" name="GDP-mannose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfbD ) or ( gmd ) or ( gmd ) or ( MUR1 ) or ( gmd ) or ( gmd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( GDP-mannose 4,6-dehydratase ) or ( GDP-mannose 4,6-dehydratase subunit ) or ( GDP-D-mannose 4,6-dehydratase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-&amp;alpha;-D-perosamine biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-6-deoxy-D-talose biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-D-rhamnose biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-L-colitose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.47</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__33__45__RXN" name="Glucose-1-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ascA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-D-glucose-1-phosphate cytidylyltransferase monomer )</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.33</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCGLUDESUCC__45__RXN" name="succinylglutamate desuccinylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( astE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: arginine degradation II (AST pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.96</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N2__45__SUCCINYLGLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9220" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: menaquinone-6 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9732" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9724" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__AMINOADIPATE__45__AMINOTRANSFERASE__45__RXN" name="2-aminoadipate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Aadat ) or ( AADAT ) or ( lysN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-aminoadipate aminotransferase subunit ) or ( 2-aminoadipate-2-oxoglutarate subunit ) or ( &amp;alpha;-aminoadipate aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.39</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__KINASE__45__RXN" name="Choline kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LOC_Os01g51920.1 ) or ( LOC_Os05g45880.1 ) or ( AT1G71697 ) or ( LOC_Os01g08760.1 ) or ( GmCK1 ) or ( GmCK2 ) or ( AT1G74320 ) or ( CKI1 ) or ( AT4G09760 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline/ethanolamine kinase, putative, expressed ) or ( ethanolamine kinase 1, putative, expressed ) or ( choline kinase ) or ( choline/ethanolamine kinase, putative, expressed ) or ( NA ) or ( NA ) or ( choline kinase ) or ( NA ) or ( choline kinase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.32</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__HEXADECENAL__45__REDUCTASE__45__RXN" name="2-hexadecenal reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Ptgr1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostaglandin reductase 1 )</html:p>
<html:p>SUBSYSTEM: sphingosine and sphingosine-1-phosphate metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.27</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__292" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMITALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOLINATE__45__SYNTHA__45__RXN" name="quinolinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At5g50210 ) or ( nadA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.72</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: DIHYDROXY__45__ACETONE__45__PHOSPHATE</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="IMINOASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOSYLNICOTINAMIDE__45__KINASE__45__RXN" name="Ribosylnicotinamide kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NRK1 ) or ( nadR ) or ( nadR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NadR transcriptional repressor )</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway III</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.22</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__2__46__26__45__RXN" name="L-&amp;delta;-(&amp;alpha;-aminoadipoyl)-L-cysteinyl-D-valine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PCBAB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of penicillin, cephalosporin and cephamycin biosynthesis</html:p>
<html:p>SUBSYSTEM: isopenicillin N biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.26</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__5S__45__5__45__AMINO__45__5__45__CARBOXYPENTANOYL__45__L__45__CY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_ACETYL__45__COA_COF_RXN" name="CO-A_TO_ACETYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIOSEPISOMERIZATION__45__RXN" name="Triosephosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPI ) or ( tpiA ) or ( pgk ) or (  ) or ( tpiA ) or ( tpiA ) or (  ) or (  ) or ( tpiA ) or ( tpiA ) or ( tpiA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( triose phosphate isomerase subunit ) or ( Pgk ) or ( triose phosphate isomerase ) or ( triose phosphate isomerase monomer ) or ( NA ) or ( NA ) or ( NA ) or ( TpiA ) or ( triosephosphate isomerase subunit ) or ( triosephosphate isomerase subunit )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: glycolysis IV (plant cytosol)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNOSE__45__6__45__PHOSPHATE__45__6__45__REDUCTASE__45__RXN" name="Mannose-6-phosphate 6-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( M6PR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannose 6-phosphate reductase )</html:p>
<html:p>SUBSYSTEM: mannitol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.224</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNITOL__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLOSE__45__1__45__DEHYDROGENASE__45__RXN" name="D-xylose 1-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( xylB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.175</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__360" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__5__46__2__45__RXN" name="Thiosulfate dehydrogenase (quinone)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( doxA and doxD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiosulphate:quinone oxidoreductase large subunit and thiosulphate:quinone oxidoreductase small subunit )</html:p>
<html:p>SUBSYSTEM: thiosulfate oxidation III (via tetrathionate)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur oxidation (Acidianus ambivalens)</html:p>
<html:p>PROTEIN_CLASS: 1.8.5.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CPD__45__7249</html:p>
<html:p>SIDE: CPD__45__7248</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="2"/>
      <speciesReference species="CPD__45__7248" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__14" stoichiometry="1"/>
      <speciesReference species="CPD__45__7249" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__RACEMASE__45__RXN" name="Ornithine racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine racemase subunit )</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__217" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R341__45__RXN" name="hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CobB )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__687" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__688" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROGESTERONE__45__5__45__ALPHA__45__REDUCTASE__45__RXN" name="Progesterone 5-&amp;alpha;-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 5&amp;alpha;-POR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cardenolide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.30</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROGESTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__293" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__221" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TYDC1 ) or ( TYDC2 ) or ( DDC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( aromatic-L-amino-acid decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis (via dopamine)</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>SUBSYSTEM: (S)-reticuline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="VCREDCHLOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( vcrB and vcrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( vinyl chloride reductase membrane anchor subunit and vinyl chloride reductase catalytic subunit )</html:p>
<html:p>SUBSYSTEM: tetrachloroethene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VINYL__45__CHLORIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHYLENE__45__CMPD" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TAURINE__45__AMINOTRANSFERASE__45__RXN" name="Taurine:pyruvate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( tpa ) or ( tpa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( taurnine:pyruvate aminotransferase subunit ) or ( taurine-pyruvate aminotransferase )</html:p>
<html:p>SUBSYSTEM: taurine degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of taurine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.77</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFOACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROKAEMPFEROL__45__4__45__REDUCTASE__45__RXN" name="Dihydrokaempferol 4-reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4g35420 ) or ( TT3 ) or ( AT4g33360 ) or ( At1g25460 ) or ( AT4g27250 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroflavonol 4-reductase ) or ( dihydroflavonol 4-reductase ) or ( dihydroflavonol 4-reductase ) or ( dihydroflavonol 4-reductase ) or ( dihydroflavonol 4-reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: leucopelargonidin and leucocyanidin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.219</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROKAEMPFEROL__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LEUCOPELARGONIDIN__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__PHOSPHO__45__BETA__45__GLUCOSIDASE__45__RXN" name="6-phospho-&amp;beta;-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bglB ) or ( chbF ) or ( ascB ) or ( glvG ) or ( bglA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phospho-&amp;beta;-glucosidase B; cryptic ) or ( diacetylchitobiose-6-phosphate hydrolase ) or ( 6-phospho-&amp;beta;-glucosidase; cryptic ) or ( probable 6-phospho-&amp;beta;-glucosidase ) or ( 6-phospho-&amp;beta;-glucosidase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.86</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__507" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3483" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ammonia oxidation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3344" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3482" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ammonia oxidation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYLAMINE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3344" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TCEREDCHLOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pceC ) or ( pceA ) or ( pceA ) or ( tceA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tetrachloroethene reductive dehalogenase subunit ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrachloroethene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRICHLOROETHENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DICHLOROETHENE" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diamine oxidase )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.22</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__73__45__RXN" name="1,2-dihydrovomilenine reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.73</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_12__45__DIHYDROVOMILENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_17__45__O__45__ACETYLNORAJMALINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__OXIDASE__45__RXN" name="Sulfite oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SUOX ) or ( SOX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfite oxidase subunit ) or ( SO subunit )</html:p>
<html:p>SUBSYSTEM: sulfite oxidation IV</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.8.3.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALD2 ) or ( ALD6 ) or (  ) or ( ALD3 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( magnesium-activated aldehyde dehydrogenase, cytosolic ) or ( 3-aminopropionaldehyde dehydrogenase ) or ( NA ) or ( aminopropionaldehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6383" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pcs ) or ( Msed_2001 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( propionyl-CoA synthase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate cycle</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LOGANATE__45__O__45__METHYLTRANSFERASE__45__RXN" name="Loganate O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( EUO57974 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.50</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LOGANATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LOGANIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R203__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xenB ) or ( xenA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: nitroglycerin degradation</html:p>
<html:p>PROTEIN_CLASS: 1.7.3.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__143" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="CPD__45__144" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8508" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP720B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abietadienol/abietadienal oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: abietic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8691" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8692" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8509" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: abietic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8692" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8693" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PABASYN__45__RXN" name="Aminodeoxychorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pabB and pabA ) or ( AY425708 ) or ( AY096797 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PabB and PabA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.85</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__4__45__DEOXYCHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8500" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AOS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 9-LOX and 9-AOS pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8678" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8682" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 9-LOX and 9-AOS pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8681" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8683" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STRICTOSIDINE__45__BETA__45__GLUCOSIDASE__45__RXN" name="Strictosidine &amp;beta;-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( strictosidine glucosidase )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.105</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="STRICTOSIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="STRICTOSIDINE__45__AGLYCONE" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8504" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: divinyl ether biosynthesis II (13-LOX)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_13__45__HYDROPEROXYOCTADECA__45__911__45__DIENOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8690" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8505" name="4-hydroxyphenylacetate 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hpaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyphenylacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.-</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXYPHENYLACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8502" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( OsHPL2 ) or ( OsHPL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 9-LOX and 9-HPL pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8677" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8684" stoichiometry="1"/>
      <speciesReference species="CPD__45__8686" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8503" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( OsHPL2 ) or ( OsHPL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 9-LOX and 9-HPL pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8678" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8685" stoichiometry="1"/>
      <speciesReference species="CPD__45__8686" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__CINNAMATE__45__4__45__MONOOXYGENASE__45__RXN" name="Trans-cinnamate 4-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ATC4H )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cinnamate 4-hydroxylase )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis, initial reactions</html:p>
<html:p>SUBSYSTEM: suberin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.11</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__674" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COUMARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRATREDUCT__45__RXN" name="Nitrate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( narI and narG and narH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( respiratory nitrate reductase &amp;alpha; subunit and respiratory nitrate reductase &amp;gamma; subunit and respiratory nitrate reductase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: nitrate reduction I (denitrification)</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.4</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGININE__45__N__45__SUCCINYLTRANSFERASE__45__RXN" name="Arginine N-succinyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( astA ) or ( aruG and aruF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( arginine succinyltransferase &amp;beta; subunit and arginine succinyltransferase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: arginine degradation II (AST pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.109</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__421" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__281" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SQS1 ) or ( FDFT1 ) or ( PSS ) or ( SQS2 ) or ( ERG9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene synthase ) or ( farnesyl-diphosphate farnesyltransferase ) or ( NA ) or ( squalene synthase ) or ( squalene synthetase )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG1 ) or ( SQLE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene monooxygenase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: diploterol and cycloartenol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4G25970 ) or ( AT4G16700 ) or ( AT5G57190 ) or ( PISD ) or ( LOC_Os01g72940.1 ) or ( LOC_Os03g01216.1 ) or ( psd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine decarboxylase ) or ( phosphatidylserine decarboxylase ) or ( NA ) or ( phosphatidylserine decarboxylase ) or ( phosphatidylserine decarboxylase, putative, expressed ) or ( phosphatidylserine decarboxylase, putative, expressed ) or ( phosphatidylserine decarboxylase, &amp;beta; subunit and phosphatidylserine decarboxylase, &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylethanolamine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.65</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANGANESE__45__PEROXIDASE__45__RXN" name="Manganese peroxidase. Mn-dependent peroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MNP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( manganese peroxidase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MN__43__2" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MN__43__3" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__4__46__1__46__6__45__RXN" name="Acetone carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acxC and acxB and acxA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetone carboxylase &amp;alpha; subunit and acetone carboxylase &amp;gamma; subunit and acetone carboxylase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: acetone degradation II (to acetoacetate)</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.6</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__LYSINE__45__OXIDASE__45__RXN" name="L-lysine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-lysine &amp;alpha;-oxidase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation VII</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.14</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__6__45__AMINO__45__CAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINYL__45__PYRUVATE__45__SPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYMETHYLENEBUTENOLIDASE__45__RXN" name="Carboxymethylenebutenolidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tfdEI ) or ( clcD ) or ( tcbE ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dienelactone hydrolase I ) or ( dienelactone hydrolase ) or ( NA ) or ( dienelactone hydrolase )</html:p>
<html:p>SUBSYSTEM: 4-chlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.45</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__CARBOXYMETHYLENEBUT__45__2__45__EN__45__4__45__OLIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( linE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-hexachlorocyclohexane degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROHYDROQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GULONATE__45__3__45__DEHYDROGENASE__45__RXN" name="L-gulonate 3-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CRYL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-gulonate 3-dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: glucuronate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.45</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETO__45__L__45__GULONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMIDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hisF and hisH ) or ( hisF and hisH ) or ( At-HF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( imidazole glycerol phosphate synthase, HisF subunit and imidazole glycerol phosphate synthase, HisH subunit ) or ( cycloligase subunit and glutamine amidotransferase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINATEPRIBOSYLTRANS__45__RXN" name="Nicotinate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( NPT1 ) or ( pncB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( nicotinate phosphoribosyl transferase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling (plants)</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.11</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8528" name="syn-copalyl diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyc1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: diterpene phytoalexins precursors biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8719" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8529" name="4-oxalocrotonate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-oxalocrotonate tautomerase subunit )</html:p>
<html:p>SUBSYSTEM: catechol degradation II (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: catechol degradation to 2-oxopent-4-enoate II</html:p>
<html:p>SUBSYSTEM: orthanilate degradation</html:p>
<html:p>SUBSYSTEM: meta cleavage pathway of aromatic compounds</html:p>
<html:p>PROTEIN_CLASS: 5.3.2.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8720" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__246" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8527" name="2-hydroxymuconate semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxymuconate semialdehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: catechol degradation II (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: catechol degradation to 2-oxopent-4-enoate II</html:p>
<html:p>SUBSYSTEM: meta cleavage pathway of aromatic compounds</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMUCONATE__45__SALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8720" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPICRED__45__RXN" name="Dihydrodipicolinate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dapB ) or ( dapB ) or ( dapB ) or ( dapB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DapB ) or ( dihydrodipicolinate reductase subunit ) or ( dihydropicolinate reductase subunit ) or ( dihydropicolinate reductase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis II</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis VI</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis III</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.26</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8525" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: palustric acid biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8715" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8716" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8521" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: neoabietic acid biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8710" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8711" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__141__45__RXN" name="4-&amp;alpha;-D-{(1->4)-&amp;alpha;-D-glucano}-trehalose trehalohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( treZ ) or ( treZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.141</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOOLIGOSYLTREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__DECARBOXYLASE__45__RXN" name="UDP-glucuronate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UXS1 ) or ( UXS2 ) or ( UDPGlcADCX1 ) or ( UXS3 ) or (  ) or ( AXS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( subunit of UDP-glucuronate decarboxylase ) or ( NA ) or ( NA ) or ( UDP-D-glucuronate decarboxylase subunit ) or ( UDP-D-apiose/UDP-D-xylose synthase subunit )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-xylose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.35</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="Myo-inositol-1(or 4)-monophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TM1415 ) or ( MJ109 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol monophosphatase subunit ) or ( inositol monophosphatase subunit )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTMPKI__45__RXN" name="Thymidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tmk ) or ( tmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACCASE__45__RXN" name="Laccase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lcc1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( laccase I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOSEMIQUINONE" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8517" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP720B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abietadienol/abietadienal oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: levopimaric acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8705" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8706" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROGENSULFITE__45__REDUCTASE__45__RXN" name="Hydrogensulfite reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dsrB and dsrA ) or ( dsvC and dsvB and dsvA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfite reductase &amp;beta; subunit and sulfite reductase &amp;alpha; subunit and sulfite reductase &amp;gamma; subunit ) or ( dissimilatory sulfite reductase &amp;gamma; subunit and dissimilatory sulfite reductase &amp;alpha; subunit and dissimilatory sulfite reductase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: sulfate reduction IV (dissimilatory)</html:p>
<html:p>PROTEIN_CLASS: 1.8.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OH</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HSO3" stoichiometry="3"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__552" stoichiometry="1"/>
      <speciesReference species="OH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTAGLY__45__RXN" name="Cystathionine &amp;gamma;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cth ) or (  ) or ( CYS3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine &amp;gamma;-lyase subunit ) or ( L-cysteine desulfhydrase ) or ( Cys3 )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis/homocysteine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8513" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-LAS ) or ( TPS-LAS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( levopimaradiene/abietadiene synthase ) or ( levopimaradiene/abietadiene synthase )</html:p>
<html:p>SUBSYSTEM: palustric acid biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4750" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8697" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__11417" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sphk1 ) or ( Sphk2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingosine kinase 1 ) or ( sphingosine kinase 2 )</html:p>
<html:p>SUBSYSTEM: sphingosine and sphingosine-1-phosphate metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD3DJ__45__11366" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8514" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Iso )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abietadiene synthase )</html:p>
<html:p>SUBSYSTEM: isopimaric acid biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4750" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8699" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__20__46__1__45__RXN" name="Deacetoxycephalosporin-C synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cefE ) or ( CEFEF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( deacetoxycephalosporin C synthase / deacetoxycephalosporin C hydroxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of penicillin, cephalosporin and cephamycin biosynthesis</html:p>
<html:p>SUBSYSTEM: deacetylcephalosporin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.20.1</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PENICILLIN__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEACETOXYCEPHALOSPORIN__45__C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8516" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: levopimaric acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8706" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8707" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8510" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP720B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abietadienol/abietadienal oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: abietic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8693" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8694" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8511" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-LAS ) or ( TPS-LAS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( levopimaradiene/abietadiene synthase ) or ( levopimaradiene/abietadiene synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>SUBSYSTEM: levopimaric acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4750" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8695" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8512" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-LAS ) or ( TPS-LAS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( levopimaradiene/abietadiene synthase ) or ( levopimaradiene/abietadiene synthase )</html:p>
<html:p>SUBSYSTEM: neoabietic acid biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of diterpene resin acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4750" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8696" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALGINATE__45__SYNTHASE__45__RXN" name="Alginate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: alginate biosynthesis I</html:p>
<html:p>SUBSYSTEM: alginate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.33</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALGINATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__1828" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10617" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GARTRANSFORMYL2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( purT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GAR transformylase 2 )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MUCONATE__45__CYCLOISOMERASE__45__RXN" name="Muconate cycloisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( catB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( muconate lactonizing enzyme subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: aromatic compounds degradation via &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: catechol degradation to &amp;beta;-ketoadipate</html:p>
<html:p>SUBSYSTEM: catechol degradation III (ortho-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__CIS__45__MUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__741" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R215__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__291" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__301" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NMNAMIDOHYDRO__45__RXN" name="Nicotinamide-nucleotide amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.42</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9291" name="stemod-13(17)-ene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( KS11 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: diterpene phytoalexins precursors biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.34</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8719" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9907" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9290" name="momilactone-A synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OsMAS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.295</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9905" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7092" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9296" name="CTP-dependent riboflavin kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rfk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.161</html:p>
<html:p>COFACTOR: CDP</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NOCARDICIN__45__A__45__EPIMERASE__45__RXN" name="Nocardicin-A epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nocJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISONOCARDICIN__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NOCARDICIN__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYMANDELATE__45__OXY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mdlB ) or ( mdlB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: 4-hydroxymandelate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__106" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__142" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9299" name="ent-sandaracopimaradiene synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ORF3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ENT__45__COPALYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9919" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__214__45__RXN" name="Glycoprotein 3-&amp;alpha;-L-fucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FUT11 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.214</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12" stoichiometry="1"/>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9297" name="N-acetylhexosamine 1-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lnpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.162</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__acetyl__45__D__45__hexosamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__N__45__acetyl__45__a__45__D__45__hexosamine__45__1__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bbsH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phenylitaconyl-CoA hydratase subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoyl-CoA (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="E__45__PHENYLITACONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYMETHYL__45__HYDROXYPHENYLPROPCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RHAMNULPALDOL__45__RXN" name="Rhamnulose-1-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rhaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( rhamnulose-1-phosphate aldolase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of fucose and rhamnose degradation</html:p>
<html:p>SUBSYSTEM: rhamnose degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RHAMNULOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTALD" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCORNTRANSAM__45__RXN" name="Succinylornithine transaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aruC ) or ( astC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinylornithine transaminase subunit ) or ( AstC )</html:p>
<html:p>SUBSYSTEM: arginine degradation II (AST pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.81</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N2__45__SUCCINYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__904" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bbsB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzoylsuccinyl-CoA thiolase subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoyl-CoA (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOYLSUCCINYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__905" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bbsD and bbsC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 3-hydroxyacyl-CoA dehydrogenase and putative 3-hydroxyacyl-CoA dehydrogenase )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoyl-CoA (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBOXYMETHYL__45__HYDROXYPHENYLPROPCOA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOYLSUCCINYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TAGAKIN__45__RXN" name="Tagatose-6-phosphate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pfkB ) or ( lacC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructokinase-2 monomer ) or ( D-tagatose-6-phosphate kinase subunit )</html:p>
<html:p>SUBSYSTEM: galactitol degradation</html:p>
<html:p>SUBSYSTEM: lactose and galactose degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.144</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAGATOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAGATOSE__45__1__45__6__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__A2__45__RXN" name="Phospholipase A2" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtsPLA2-gamma ) or ( AtPLA IVA ) or ( AtsPLA2-alpha )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( AtPLA IVA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.4</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OXOGLUTARATE__45__ALDOLASE__45__RXN" name="4-hydroxy-4-methyl-2-oxoglutarate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( pmdF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxy-4-methyl-2-oxoglutarate aldolase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>SUBSYSTEM: methylgallate degradation</html:p>
<html:p>SUBSYSTEM: gallate degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.17</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__OH__45__4__45__ACETYL__45__2__45__OXOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R302__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pfkA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-dependent phosphofructokinase subunit )</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.146</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2882" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fae )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formaldehyde-activating enzyme subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation VI (H4MPT pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: THMPT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="THMPT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENETETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3422" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At5g20230 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: free phenylpropanoid acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.68</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__HYDROXY__45__FERULIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SINAPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMACTRANS__45__RXN" name="Diamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( speG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SpeG )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aliphatic__45__N__45__Acetyl__45__Diamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2883" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mtdA ) or ( mtdB ) or ( mtdB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent methylene tetrahydromethanoptrin dehydrogenase subunit ) or ( MtdB ) or ( MtdB )</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation VI (H4MPT pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENETETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHENYLTETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="adenylosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade12 ) or ( purA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ade12 ) or ( PurA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: adenosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.4</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2884" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fhcA and fhcD and fhcC and fhcB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formyltransferase/hydrolase complex &amp;gamma; subunit and formyltransferase/hydrolase complex &amp;delta; subunit and formyltransferase/hydrolase complex &amp;beta; subunit and formyltransferase/hydrolase complex &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation VI (H4MPT pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: THMPT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THMPT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="THMPT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHBAMPLIG__45__RXN" name="(2,3-dihydroxybenzoyl)adenylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( dhbE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( EntE ) or ( DhbE monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.58</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__3__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__62" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIKIN__45__RXN" name="Thiamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( thiK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamin kinase )</html:p>
<html:p>SUBSYSTEM: thiamin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.89</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPHENYLPYRUVATE__45__REDUCTASE__45__RXN" name="Hydroxyphenylpyruvate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxybenzoate biosynthesis I (eukaryotes)</html:p>
<html:p>SUBSYSTEM: 4-hydroxybenzoate biosynthesis III (yeast)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.237</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXYPHENYLLACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9276" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SANGUINARINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSANGUINARINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9275" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.12</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROCHELIRUBINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9893" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__69__45__RXN" name="Alkene monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aamB and aamF and aamA and aamE and aamD and aamC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alkene monooxygenase reductase subunit and alkene monooxygenase coupling/effector subunit and alkene monooxygenase ferredoxin subunit monomer and alkene monooxygenase oxygenase component &amp;gamma; subunit and alkene monooxygenase oxygenase component &amp;beta; subunit and alkene monooxygenase oxygenase component &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: propylene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.69</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__12__45__EPOXYPROPANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__NITROPHENOL__45__2__45__MONOOXYGENASE__45__RXN" name="2-nitrophenol 2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2-nitrophenol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.31</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__258" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__4__46__9__45__RXN" name="Adenylyl-sulfate reductase (glutathione)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lapr ) or ( APR2 ) or ( APR3 ) or ( APR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine 5&apos;-phosphosulphate reductase subunit ) or ( APR2 ) or ( APR3 ) or ( APR1 )</html:p>
<html:p>SUBSYSTEM: sulfate reduction II (assimilatory)</html:p>
<html:p>PROTEIN_CLASS: 1.8.4.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>SIDE: OXIDIZED__45__GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APS" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__16__45__RXN" name="Serine/threonine specific protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pphB ) or ( pphA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( protein phosphatase 1 modulates phosphoproteins, signals protein misfolding )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.16</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOATE__45__BETA__45__ALANINE__45__LIG__45__RXN" name="Pantoate--&amp;beta;-alanine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PANC ) or ( panC ) or ( PANC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantoate:&amp;beta;-alanine ligase ) or ( pantothenate synthetase monomer ) or ( pantoate:&amp;beta;-alanine ligase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="L__45__PANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUERCETIN__45__23__45__DIOXYGENASE__45__RXN" name="Quercetin 2,3-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( yhhW )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quercetin 2,3-dioxygenase ) or ( pirin-like protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.24</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__520" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PROTOCATECHUOYLPHLOROGLUCINOLCARBOXYLA" stoichiometry="1"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9281" name="Hexaprenyldihydroxybenzoate methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Coq3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.114</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9896" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9898" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFOACETALDEHYDE__45__LYASE__45__RXN" name="Sulfoacetaldehyde lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SULFOACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCIT__45__CLEAV__45__RXN" name="Isocitrate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( icl ) or ( icl ) or ( aceA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate lyase ) or ( isocitrate lyase subunit ) or ( isocitrate lyase monomer )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYPHENYLPYRUVATE__45__DIOXYGENASE__45__RXN" name="4-hydroxyphenylpyruvate dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDS1 ) or (  ) or ( HPD ) or ( slr0090 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxyphenylpyruvate dioxygenase ) or ( 4-hydroxyphenylpyruvate dioxygenase subunit ) or ( 4-hydroxyphenylpyruvate dioxygenase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: vitamin E biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.27</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9282" name="Hexaprenyldihydroxybenzoate methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.114</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9895" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9897" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHSHIKIMATE__45__DEHYDRO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( quiC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of aromatic compound degradation (aerobic)</html:p>
<html:p>SUBSYSTEM: shikimate degradation</html:p>
<html:p>SUBSYSTEM: quinate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__DEHYDRO__45__SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTOLDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hisD ) or ( hisD ) or ( HDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( HisD ) or ( histidinol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__4__45__EPIMERASE__45__RXN" name="UDP-glucuronate 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GAE4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of UDP-GlcA 4-epimerase )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-galacturonate biosynthesis I (from UDP-D-glucuronate)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__D__45__GALACTURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHLAXANAU__45__RXN" name="Haloalkane dehalogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dhlA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 1,2-dichloroethane degradation</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.5</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_12__45__DICHLOROETHANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="_2__45__CHLOROETHANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__15__45__RXN" name="Diaminopropionate ammonia-lyase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ygeX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,3-diaminopropionate ammonia-lyase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1782" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDPHOS__45__RXN" name="Histidinol-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hisK ) or ( hisB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidinol phosphate phosphatase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.15</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTIDINOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__215__45__RXN" name="Gluconate 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ghrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GhrB )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.215</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3481" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( D7OMT ) or ( IOMT8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.150</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DAIDZEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3343" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UNDECAPRENYL__45__DIPHOSPHATASE__45__RXN" name="Undecaprenyl-diphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pgpB ) or ( bacA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( undecaprenyl pyrophosphate phosphatase )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.27</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UNDECAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__947" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox8 ) or ( GA2ox7 ) or ( GA2ox3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__95" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__475" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSENOYLCOARED__45__RXN" name="Trans-2-enoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of trans-2-enoyl-CoA reductase (NADPH) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__2__46__18__45__RXN" name="Enamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ena )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enamidase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.18</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__283" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9437" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9246" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IGS1 ) or ( CbIGS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: eugenol and isoeugenol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9875" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOEUGENOL" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__942" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bssC and bssA and bssB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzylsuccinate synthase &amp;beta; subunit and benzylsuccinate synthase &amp;gamma; subunit and benzylsuccinate synthase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: m-xylene degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="META__45__XYLENE" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYLBENZYLSUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__64__45__RXN" name="2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( menD ) or ( menD ) or ( menD ) or ( menD ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis II (plants)</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="ISOCHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9924" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCURONOKINASE__45__RXN" name="Glucuronokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-glucuronate biosynthesis (from myo-inositol)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.43</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__510" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OAHTHAUERA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( oah )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-oxoacyl-CoA hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__OXOCYCLOHEX__45__1__45__ENE__45__1__45__CARBONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXYPIMELYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PMPOXI__45__RXN" name="Pyridoxamine-phosphate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdxH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PdxH )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERATE__45__DEHYDROGENASE__45__RXN" name="Glycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G68010 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxypyruvate reductase )</html:p>
<html:p>SUBSYSTEM: photorespiration</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.29</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3463" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydrazine/hydroxylamine oxidoreductase subunit )</html:p>
<html:p>SUBSYSTEM: ammonia oxidation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.7.99.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDRAZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__" stoichiometry="4"/>
      <speciesReference species="NITROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4981" name="vitexin 2&apos;&apos;-O-rhamnoside 7-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vitexin and detivatives biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.153</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VITEXIN__45__2__45__O__45__B__45__L__45__RHAMNOSIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_7__45__O__45__METHYLVITEXIN__45__2__45__O__45__B__45__L__45__RHAMNOSIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__1__46__15__45__RXN" name="Mycothione reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mtr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mycothione reductase subunit )</html:p>
<html:p>SUBSYSTEM: mycothiol oxidation</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.15</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYCOTHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__2" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDRONEOPTERIN__45__MONO__45__P__45__DEPHOS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRO__45__NEO__45__PTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( mauA and mauB ) or ( mauA and mauB ) or ( mauA and mauB ) or ( madB and madA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylamine dehydrogenase small subunit and methylamine dehydrogenase large subunit ) or ( methylamine dehydrogenase small subunit and methylamine dehydrogenase large subunit ) or ( methylamine dehydrogenase large subunit and methylamine dehydrogenase small subunit ) or ( methylamine dehydrogenase large subunit and methylamine dehydrogenase small subunit ) or ( methylamine dehydrogenase large subunit and methylamine dehydrogenase small subunit )</html:p>
<html:p>SUBSYSTEM: methanol and methylamine oxidation to formaldehyde</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>PROTEIN_CLASS: 1.4.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOKETOLASE__45__RXN" name="Phosphoketolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xfp ) or ( xfp ) or ( LEUM_1961 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-6-phosphate phosphoketolase &amp;alpha; subunit and fructose-6-phosphate phosphoketolase &amp;beta; subunit ) or ( D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase ) or ( phosphoketolase subunit )</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__P" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALISOM__45__RXN" name="3-isopropylmalate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( leuC and leuD ) or ( leuC and leuD ) or ( leuD and leuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopropylmalate isomerase small subunit and isopropylmalate isomerase large subunit ) or ( LeuC and LeuD ) or ( isopropylmalate isomerase large subunit and isopropylmalate isomerase small subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__CARBOXY__45__3__45__HYDROXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9451" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R345__45__RXN" name="Adenosylcobyric acid synthase (glutamine-hydrolyzing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobQ ) or ( cbiP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CobQ ) or ( adenosyl-cobyrate synthase subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__691" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMHYDR__45__RXN" name="Fumarate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fumC ) or ( fumB ) or ( fumA ) or ( fumC ) or ( FH ) or (  ) or (  ) or ( HP1325 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarase C monomer ) or ( fumarase B monomer ) or ( fumarase A monomer ) or ( NA ) or ( fumarate hydratase, mitochondrial precursor ) or ( NA ) or ( NA ) or ( fumarase (fumC) )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle II</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle I</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VIII (to propionate)</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: incomplete reductive TCA cycle</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9230" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.39</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9610" stoichiometry="1"/>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9864" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTUROISOM__45__RXN" name="Glucuronate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( uxaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hexuronide and hexuronate degradation</html:p>
<html:p>SUBSYSTEM: D-galacturonate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__TAGATURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBAZOLEPHOSPHAT__45__RXN" name="&amp;alpha;-ribazole phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( cobC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( CobC )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.73</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__RIBAZOLE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__RIBAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRITREDUCT__45__RXN" name="Nitrite reductase (NAD(P)H)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nit-6 ) or ( nirD and nirB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nitrite reductase subunit ) or ( nitrite reductase, large subunit and nitrite reductase, small subunit )</html:p>
<html:p>SUBSYSTEM: nitrate reduction V (assimilatory)</html:p>
<html:p>SUBSYSTEM: 2-nitropropane degradation</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.4</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NH4OH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCYSDESULF__45__RXN" name="D-cysteine desulfhydrase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dcyD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-cysteine desulfhydrase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDHYD__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: histidine degradation VI</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDANTOIN__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMPKI__45__RXN" name="Cytidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cmk ) or ( PYR6 ) or ( cmk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( UMP/CMP kinase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__156__45__RXN" name="Phloroisovalerophenone synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CHS ) or ( VPS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( phlorisovalerophenone synthase )</html:p>
<html:p>SUBSYSTEM: humulone biosynthesis</html:p>
<html:p>SUBSYSTEM: bitter acids biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.156</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__1__45__246__45__TRIHYDROXYPHENYLBUTAN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROPRIBTRANS__45__RXN" name="Orotate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT3G54470 ) or ( pyrE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UMP synthase ) or ( PyrE )</html:p>
<html:p>SUBSYSTEM: uridine-5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STREPTOMYCIN__45__6__45__KINASE__45__RXN" name="Streptomycin 6-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( strA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.72</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="STREPTOMYCIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__529" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9243" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( clk-1 ) or ( PA0655 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9872" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7158" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9244" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CFAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: eugenol and isoeugenol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CONIFERYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9875" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9245" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CbEGS2 ) or ( CbEGS1 ) or ( EGS1 ) or ( EGS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: eugenol and isoeugenol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9875" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6481" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FOLYLPOLYGLUTAMATESYNTH__45__RXN" name="folylpolyglutamate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( folC ) or ( DHFS/FPGS4 ) or ( DHFS/FPGS2 ) or ( folC ) or ( DHFS/FPGS3 ) or (  ) or ( folC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpoly-&amp;gamma;-synthetase subunit ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( folylpoly-&amp;alpha;-glutamate synthetase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONATE__45__DEHYDRATASE__45__RXN" name="Gluconate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gad ) or ( SSO3198 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.39</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEHYDRO__45__3__45__DEOXY__45__D__45__GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>SIDE: __124__Methylated__45__methyl__45__acceptors__124__</html:p>
<html:p>SIDE: __124__Methyl__45__acceptors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4101" stoichiometry="1"/>
      <speciesReference species="__124__Methyl__45__acceptors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Methylated__45__methyl__45__acceptors__124__" stoichiometry="1"/>
      <speciesReference species="EPISTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OCTAPRENYLPHENOL__45__HYDROX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ubiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-8 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OCTAPRENYLPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OCTAPRENYL__45__6__45__HYDROXYPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HCAMULTI__45__RXN" name="3-phenylpropanoate dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hcaC and hcaD and hcaF and hcaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-phenylpropionate dioxygenase, &amp;alpha; subunit and 3-phenylpropionate dioxygenase, predicted ferredoxin subunit and 3-phenylpropionate dioxygenase, &amp;beta; subunit and NA )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.19</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__PHENYLPROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYETHYL__45__3__45__5__45__CYCLOHEXADIENE__45__1__45__2__45__DIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__58__45__RXN" name="Phenylalanine(histidine) aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( ARO9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidine-pyruvate aminotransferase subunit ) or ( aromatic amino acid aminotransferase II )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.58</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3443" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gapN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD+-dependent glyceraldehyde-3-phosphate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9236" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9871" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9873" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9237" name="3-demethylubiquinone-9 3-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (eukaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-10 biosynthesis (prokaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9873" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9958" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARABINONATE__45__DEHYDRATASE__45__RXN" name="Arabinonate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( araD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-arabinonate dehydratase subunit )</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1114" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DH__45__3__45__DO__45__D__45__ARABINONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9082" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sm2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: maysin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Non__45__Rhamonsylated__45__Rhamnosyl__45__Acceptors__124__</html:p>
<html:p>SIDE: __124__Rhamonsylated__45__Rhamonsyl__45__Acceptors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Rhamonsylated__45__Rhamonsyl__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="ISOORIENTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9587" stoichiometry="1"/>
      <speciesReference species="__124__Non__45__Rhamonsylated__45__Rhamnosyl__45__Acceptors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9081" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: maysin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: __124__Non__45__Glucosylated__45__Glucose__45__Acceptors__124__</html:p>
<html:p>SIDE: __124__Glucosylated__45__Glucose__45__Acceptors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glucosylated__45__Glucose__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="_5734__45__TETRAHYDROXYFLAVONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Non__45__Glucosylated__45__Glucose__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="ISOORIENTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9086" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pcs ) or ( Msed_1456 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( propionyl-CoA synthase subunit ) or ( 3-hydroxypropionyl-CoA synthetase subunit )</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate cycle</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9087" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Msed_1426 ) or ( pcs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acryloyl-CoA reductase (NADPH) ) or ( propionyl-CoA synthase subunit )</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate cycle</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R502__45__RXN" name="N-methylproline demethylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( stcD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: stachydrine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Methylated__45__methyl__45__acceptors__124__</html:p>
<html:p>SIDE: __124__Methyl__45__acceptors__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__904" stoichiometry="1"/>
      <speciesReference species="__124__Methyl__45__acceptors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
      <speciesReference species="__124__Methylated__45__methyl__45__acceptors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9089" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( laccase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: oligomeric urushiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9593" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="3"/>
      <speciesReference species="CPD__45__9594" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7744" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( leuC and leuD ) or ( leuD and leuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopropylmalate isomerase small subunit and isopropylmalate isomerase large subunit ) or ( isopropylmalate isomerase large subunit and isopropylmalate isomerase small subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__METHYLMALEATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7066" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7743" name="(R)-citramalate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cimA ) or ( cimA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (R)-citramalate synthase subunit ) or ( (R)-citratemalate synthase subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.182</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__31" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__45____45__MENTHOL__45__DEHYDROGENASE__45__RXN" name="(-)-menthol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MMR ) or ( MNR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( menthol dehydrogenase ) or ( neomenthol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: menthol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.207</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1909" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__45____45__MENTHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7745" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( leuB ) or ( MJ0720 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-isopropylmalate dehydrogenase subunit ) or ( 3-isopropylmalate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7066" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7740" name="Pheophorbide a oxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll a degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.20</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7061" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7063" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENETHFDEHYDROG__45__NADP__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AF030516 ) or ( folD ) or ( mtdA ) or ( folD ) or (  ) or ( MTHFD1 ) or ( folD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methenylTHF cyclohydrolase/methyleneTHF dehydrogenase subunit ) or ( CYC subunits ) or ( NA ) or ( NADP-dependent methylene tetrahydromethanoptrin dehydrogenase subunit ) or ( FolD ) or ( methylenetetrahydrofolate dehydrogenase subunit ) or ( MTHFD monomer ) or ( NA )</html:p>
<html:p>SUBSYSTEM: reductive acetyl coenzyme A pathway</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis I</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation V (tetrahydrofolate pathway)</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__14__45__RXN" name="3-aminobutyryl-CoA ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( kal )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.14</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__672" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7741" name="Red chlorophyll catabolite reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RCCR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll a degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.80</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7063" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7064" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHONOACETALDEHYDE__45__HYDROLASE__45__RXN" name="Phosphonoacetaldehyde hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphonoacetaldehyde hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: phosphonate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.11.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__551" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3161" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5421" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5502" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIDM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5421" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOCHANIN__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOSINE__45__DEHYDROGENASE__45__RXN" name="Sarcosine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sarcosine dehydrogenase &amp;alpha; subunit and sarcosine dehydrogenase subunit ) or ( sarcosine dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: creatinine degradation II</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__21__46__4__46__1__45__RXN" name="D-proline reductase (dithiol)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( prdB and prdA and prdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 45-kDa subunit and 26-kDa subunit and 23-kDa subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.21.4.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINOPENTANOATE" stoichiometry="1"/>
      <speciesReference species="LIPOIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__296" stoichiometry="1"/>
      <speciesReference species="D__45__PROLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7748" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cyp79A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dhurrin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__267" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7070" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7749" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cyp79A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dhurrin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.41</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7070" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1041" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__133__45__RXN" name="Shikimate O-hydroxycinnamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCT ) or ( HCT ) or ( At5g48930 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phenylpropanoid biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorogenic acid biosynthesis II</html:p>
<html:p>SUBSYSTEM: simple coumarins biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.133</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SHIKIMATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SHIKIMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__412" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9070" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hyp-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hypericin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8215" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9557" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R561__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: nylon-6 oligomer degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__883" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__884" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__119__45__RXN" name="10-hydroxydihydrosanguinarine 10-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.119</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_10__45__HYDROXYDIHYDROSANGUINARINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROCHELIRUBINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9071" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hyp-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hypericin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9557" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9558" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9072" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hyp-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hypericin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9558" stoichiometry="1"/>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9561" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9073" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hyp-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hypericin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9561" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9562" stoichiometry="1"/>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1727" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD8 ) or ( FAD7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2185" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__761" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( otsA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ADP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1728" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fad5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycolipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2187" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2188" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7760" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hesperitin glycoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7073" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7074" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATE__45__SYNTHASE__45__RXN" name="Chorismate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aroF ) or ( aroC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( AroC )</html:p>
<html:p>SUBSYSTEM: chorismate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.5</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__ENOLPYRUVYL__45__SHIKIMATE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ackA ) or ( tdcD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( propionate kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: threonine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.15</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7755" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: hesperitin glycoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.185</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7072" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7073" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1726" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAD6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2184" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2185" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7751" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__THREO__45__3__45__METHYL__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLOXALO__45__ACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSDECARBOX__45__RXN" name="Lysine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ldc ) or ( cadA ) or ( ldcC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysine decarboxylase subunit ) or ( CadA ) or ( LdcC ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: aminopropylcadaverine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: lysine degradation I</html:p>
<html:p>SUBSYSTEM: lupanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.18</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CADAVERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1725" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fad4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid desaturation</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2183" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2184" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7750" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IFS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.86</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__431" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3161" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4465" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4G19380 ) or ( fao1 ) or ( fao2 ) or ( AT3G23410 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( long-chain fatty alcohol oxidase ) or ( long-chain fatty alcohol oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;omega;-oxidation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OMEGA__45__HYDROXY__45__FATTY__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OMEGA__45__ALDEHYDE__45__FATTY__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R228__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( comA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ComA )</html:p>
<html:p>SUBSYSTEM: coenzyme M biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__366" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__AMINOTRANSFERASE__45__RXN" name="Tryptophan aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( ARO8 ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( aromatic amino acid aminotransferase I ) or ( NA ) or ( NA ) or ( aromatic amino acid aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VII (via indole-3-pyruvate)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IV (via indole-3-lactate)</html:p>
<html:p>SUBSYSTEM: IAA biosynthesis I</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VIII (to tryptophol)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.27</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7759" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( C12RT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,2 rhamnosyltransferase )</html:p>
<html:p>SUBSYSTEM: hesperitin glycoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.236</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7073" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7075" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__175__45__RXN" name="Deacetylcephalosporin-C acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CEFG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of penicillin, cephalosporin and cephamycin biosynthesis</html:p>
<html:p>SUBSYSTEM: cephalosporin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.175</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEACETYLCEPHALOSPORIN__45__C" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CEPHALOSPORIN__45__C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNQT__45__4142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTC4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-galactose-1-phosphate phosphatase//inositol or phosphatidylinositol phosphatase )</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis I (L-galactose pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPDQT__45__4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNQT__45__4141" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTC2 ) or ( VTC5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-L-galactose phosphorylase ) or ( GDP-L-galactose phosphorylase )</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis I (L-galactose pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__L__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPDQT__45__4" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYPYPHOSPHA__45__RXN" name="CDP-diacylglycerol pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cdh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.26</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADPSUGPPHOSPHAT__45__RXN" name="ADP-sugar diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nudF ) or ( nudE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP- sugar pyrophosphatase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.21</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__SUGARS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alpha__45__D__45__aldose__45__1__45__phosphates__124__" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__773" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid 22&amp;alpha;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis II</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__710" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__712" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__774" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CPD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 23&amp;alpha; hydroxylase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis II</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__712" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__715" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__A1__45__RXN" name="Phospholipase A1" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtLCAT3 ) or ( pldA ) or ( DAD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( DAD1 )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.32</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__778" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BR6ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( brassinosteroid-6-oxidase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__723" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__724" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__777" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ROT3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__720" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__723" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__581" name="inositol phosphoceramide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AUR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IPC synthase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: INOSITOL__45__PHOSPHATE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="__124__Alpha__45__hydroxyphytoceramides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IPC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCDIAMINOPIMDESUCC__45__RXN" name="Succinyl-diaminopimelate desuccinylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dapE ) or ( dapE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-succinyl-L,L-diaminopimelate desuccinylase subunit ) or ( N-succinyl-L-diaminopimelate desuccinylase subunit )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.18</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__SUCCINYLLL__45__2__45__6__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__779" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BR6ox1 ) or ( CYP85A3 ) or ( CYP85A2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( brassinosteroid-6-oxidase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__724" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__634" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9091" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: oligomeric urushiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9593" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="2"/>
      <speciesReference species="CPD__45__9598" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9092" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Msed_1422 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybutyryl-CoA synthetase (AMP-forming) )</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_4__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9093" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: xylan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__ARABINOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_14__45__BETA__45__D__45__XYLANS" stoichiometry="1"/>
      <speciesReference species="UDP__45__L__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9600" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9094" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: xylan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_14__45__BETA__45__D__45__XYLANS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCURONOXYLAN__45__D__45__GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9090" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( laccase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: oligomeric urushiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9593" stoichiometry="1"/>
      <speciesReference species="CPD__45__9594" stoichiometry="1"/>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="3"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9597" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANOSINE__45__DEAMINASE__45__RXN" name="Guanosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.15</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDRODIPICSYN__45__RXN" name="dihydrodipicolinate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dapA ) or ( DapA ) or ( dapA ) or ( dapA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DapA ) or ( NA ) or ( dihydrodipicolinate synthase subunit ) or ( dihydropicolinate synthase subunit )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis II</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis VI</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis III</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.52</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__DIHYDRODIPICOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GGTLA1 ) or ( ggt ) or ( GGT1 ) or ( ggt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;gamma;-glutamyltransferase large subunit and &amp;gamma;-glutamyltransferase small subunit ) or ( &amp;gamma;-glutamyl transpeptidase large subunit and &amp;gamma;-glutamyl transpeptidase small subunit ) or ( &amp;gamma;-glutamyl transpeptidase small subunit and &amp;gamma;-glutamyl transpeptidase large subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
      <speciesReference species="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7733" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( vhoA and vhoC and vhoG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( F420 non-reducing hydrogenase I, large subunit and F420 non-reducing hydrogenase I, cytochrome b subunit and F420 non-reducing hydrogenase I, small subunit )</html:p>
<html:p>SUBSYSTEM: coenzyme B/coenzyme M regeneration</html:p>
<html:p>PROTEIN_CLASS: 1.12.98.3</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="CPD__45__7323" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROMETHANOPHENAZINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7732" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: naringenin glycoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__7__45__O__45__BETA__45__D__45__GLUCOSIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7059" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCROSE__45__PHOSPHORYLASE__45__RXN" name="Sucrose phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sucP ) or ( scrP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sucrose phosphorylase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sucrose degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.7</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7738" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CLH2 ) or ( CLH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll a degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.14</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROPHYLL__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTOL" stoichiometry="1"/>
      <speciesReference species="CHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7737" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4G33680 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis VI</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.-</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__6__45__DICARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSNACMURPENTATRANS__45__RXN" name="Phospho-N-acetylmuramoyl-pentapeptide-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mraY ) or ( mraY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
      <speciesReference species="C1" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="C5" stoichiometry="1"/>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMPCYCLOHYDROLASE__45__RXN" name="IMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade17 ) or ( purH ) or ( ade16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ade17 ) or ( NA ) or ( Ade16 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7793" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GCS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.80</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Glucosyl__45__Ceramides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7792" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceramide synthase )</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( caiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CaiB monomer )</html:p>
<html:p>SUBSYSTEM: carnitine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>SIDE: GAMMA__45__BUTYROBETAINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
      <speciesReference species="GAMMA__45__BUTYROBETAINYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__BUTYROBETAINE" stoichiometry="1"/>
      <speciesReference species="L__45__CARNITINYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1382" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( frc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formyl-CoA transferase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALATE" stoichiometry="1"/>
      <speciesReference species="FORMYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALYL__45__COA" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__30__45__RXN" name="Pyridoxamine--pyruvate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ppat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxamine-pyruvate aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: vitamin B6 degradation</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.30</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENMETSYN__45__RXN" name="Methionine adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SAM-1 ) or ( pOS-SAMS2 ) or ( sam1 ) or ( Mat1a ) or ( sam2 ) or ( SAMS1 ) or ( metK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine synthetase ) or ( NA ) or ( Sam1 ) or ( methionine adenosyltransferase I, &amp;alpha; subunit ) or ( Sam2 ) or ( NA ) or ( methionine adenosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: ethylene biosynthesis from methionine</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: 2&apos;-deoxymugineic acid phytosiderophore biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R22__45__RXN" name="Butyryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bcd ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glutamate degradation V (via hydroxyglutarate)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>SUBSYSTEM: succinate fermentation to butyrate</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate II</html:p>
<html:p>SUBSYSTEM: gallate degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R543__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( camP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxygenating component of camphor 1,2-monooxygenase subunit and NADH oxidase )</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__864" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__865" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__719" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ROT3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__719" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__634" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHELENE__45__THMPT__45__OXI__45__RXN" name="Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mer )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mer )</html:p>
<html:p>SUBSYSTEM: methanogenesis from CO2</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Reduced__45__Factor__45__F420__124__" stoichiometry="1"/>
      <speciesReference species="METHYLENETETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYL__45__THMPT" stoichiometry="1"/>
      <speciesReference species="__124__Oxidized__45__Factor__45__F420__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__715" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steroid 22&amp;alpha;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__713" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__714" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__716" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CPD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 23&amp;alpha; hydroxylase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__714" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__716" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7788" name="ent-pimara-8(14),15-diene synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OsKS5 ) or ( KS10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.30</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ENT__45__COPALYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7097" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__II__45__RXN" name="GTP cyclohydrolase II" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ribA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP cyclohydrolase II )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.25</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="DIAMINO__45__OH__45__PHOSPHORIBOSYLAMINO__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__711" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DET2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxo-5&amp;alpha;-steroid 4-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis II</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__698" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__709" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7783" name="Flavonoid 3&apos;,5&apos;-hydroxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Hf1 ) or ( Hf2 ) or ( TG1 ) or ( AJ011862 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.88</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FLAVANONES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Hydroxyflavonones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7784" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: leucodelphinidin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.219</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7087" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7088" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7785" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ans )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: anthocyanin biosynthesis (delphinidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7088" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7090" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__710" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis II</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.145</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__708" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__698" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSOPHOSPHOLIPASE__45__RXN" name="Lysophospholipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tesA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__GLYCERO__45__PHOSPHORYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHACYL__45__COA__45__DEHYDROG__45__RXN" name="3-hydroxyacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hbd ) or (  ) or (  ) or (  ) or ( fadB ) or ( fadJ ) or ( MFP-a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-hydroxybutyryl-CoA dehydrogenase subunit ) or ( MFP I ) or ( MFP III ) or ( MFP II ) or ( dodecenoyl-CoA &amp;delta;-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase ) or ( FadJ monomer ) or ( MFP a )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="EXOPOLYPHOSPHATASE__45__RXN" name="Exopolyphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ppx )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( exopolyphosphatase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.11</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TOLUENE__45__4__45__MONOOXYGENASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tmoF and tmoB and tmoE and tmoC and tmoD and tmoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( toluene-4-monooxygenase complex hydroxylase complex &amp;gamma; subunit and toluene-4-monooxygenase complex hydroxylase complex &amp;beta; subunit and toluene-4-monooxygenase complex NADH oxidoreductase component and NADH oxidoreductase ferredoxin component and NADH oxidoreductase catalytic/effector component and toluene-4-monooxygenase complex hydroxylase complex &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation to protocatechuate (via p-cresol)</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation III (aerobic) (via p-cresol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TOLUENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINAMARIN__45__SYNTHASE__45__RXN" name="Linamarin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of linamarin and lotaustralin biosynthesis</html:p>
<html:p>SUBSYSTEM: linamarin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.63</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXY__45__2__45__METHYLPROPANENITRILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LINAMARIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MHPCHYDROL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mhpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__157" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXOPENTENOATE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7798" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AF406816 ) or ( AT3G61580 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__III__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Plant__45__Ceramides__45__IV__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UPPSYN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of undecaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CIS__45__TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7799" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G51290 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.138</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Plant__45__Ceramide__45__Phosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__720" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP85A3 ) or ( CYP85A2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__634" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__697" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7796" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT2G34770 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Plant__45__Ceramides__45__II__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STR2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: CPD__45__667</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGANINE__45__1__45__PHOSPHATE__45__ALDOLASE__45__RXN" name="Sphinganine-1-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DPL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrosphingosine phosphate lyase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.27</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMITALDEHYDE" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7797" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Plant__45__Ceramides__45__III__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7795" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>SIDE: __124__L__45__1__45__phosphatidyl__45__inositols__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="__124__Inositolphosphoryl__45__Ceramides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PORC ) or ( PORA ) or ( bchN and bchL and bchB ) or ( PORB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protochlorophyllide oxidoreductase ) or ( protochlorophyllide oxidoreductase ) or ( light-independent protochlorophyllide reductase subunit L and light-independent protochlorophyllide reductase subunit  N and light-independent protochlorophyllide reductase subunit  B ) or ( protochlorophyllide oxidoreductase )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MONO__45__VINYL__45__PROTOCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__6__46__5__46__6__45__RXN" name="p-benzoquinone reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pnpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrophenol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.6</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__BENZOQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7771" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GME ) or ( GME )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( GDP-D-mannose-3,5-epimerase )</html:p>
<html:p>SUBSYSTEM: GDP-L-galactose biosynthesis</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis II (L-gulose pathway)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7078" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7770" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AXS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-D-glucuronate decarboxylase subunit ) or ( UDP-D-apiose/UDP-D-xylose synthase subunit )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-apiose biosynthesis (from UDP-D-glucuronate)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__APIOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP_TO_UTP_COF_RXN" name="UDP_TO_UTP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__247__45__RXN" name="Codeinone reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COR1.1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( codeinone reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: morphine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.247</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CODEINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CODEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROHEX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( HPL1 )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: 13-LOX and 13-HPL pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_13__45__HYDROPEROXYOCTADECA__45__911__45__DIENOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEXANAL" stoichiometry="1"/>
      <speciesReference species="_12__45__OXO__45__CIS__45__9__45__DODECENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__50__45__RXN" name="Glutamine--scyllo-inosose aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( stsC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L:glutamine:2-keto-myo-inositol aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.50</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: _2__45__KETO__45__GLUTARAMATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
      <speciesReference species="CPD__45__365" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__GLUTARAMATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__1105" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__19" name="hydroperoxide dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AOS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allene oxide synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: jasmonic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.92</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__725" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__728" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLNEURAMINATE__45__SYNTHASE__45__RXN" name="N-acetylneuraminate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( neuB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylneuraminate synthase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLNEURAMINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7763" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phytol salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.-</html:p>
<html:p>SIDE: __124__Nucleoside__45__Triphosphates__124__</html:p>
<html:p>SIDE: __124__Nucleoside__45__Diphosphates__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7025" stoichiometry="1"/>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
      <speciesReference species="PHYTYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7782" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AJ011862 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: syringetin biosynthesis</html:p>
<html:p>SUBSYSTEM: leucodelphinidin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROKAEMPFEROL__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7087" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNQT__45__4192" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CER4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol-forming fatty acyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: cuticular wax biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VERY__45__LONG__45__CHAIN__45__FATTY__45__ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__aprimaryalcohol__124__" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNQT__45__4193" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5G37300 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cuticular wax biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.75</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__aprimaryalcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Wax__45__Esters__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOCARBOLIG__45__RXN" name="Tartronate-semialdehyde synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gcl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Gcl )</html:p>
<html:p>SUBSYSTEM: superpathway of glycol metabolism and degradation</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.47</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCLOHEXYLAMINE__45__OXIDASE__45__RXN" name="cyclohexylamine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__303" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYCLOHEXANONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__21__45__RXN" name="Farnesyl-diphosphate farnesyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SQS1 ) or ( FDFT1 ) or ( PSS ) or ( crtM ) or ( SQS2 ) or ( ERG9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene synthase ) or ( farnesyl-diphosphate farnesyltransferase ) or ( NA ) or ( NA ) or ( squalene synthase ) or ( squalene synthetase )</html:p>
<html:p>SUBSYSTEM: staphyloxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROLINE__45__MULTI" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( proA and proB ) or ( P5CS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ProB and ProA ) or ( &amp;delta;1-pyrroline-5-carboxylate synthetase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTAMINOTRANS__45__RXN" name="Histidinol-phosphate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hisC ) or ( hisC ) or ( hisC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( HisC ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.9</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7774" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( menD ) or ( kgd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.71</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__743" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dhurrin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.85</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__648" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1042" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__NACMURALGLDAPLIG__45__RXN" name="UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( murE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7775" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( TT6 ) or ( AN3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( flavanone 3&amp;beta;-hydroxylase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: leucodelphinidin biosynthesis</html:p>
<html:p>SUBSYSTEM: leucopelargonidin and leucocyanidin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.9</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6994" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__474" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7772" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GME ) or ( GME )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( GDP-D-mannose-3,5-epimerase )</html:p>
<html:p>SUBSYSTEM: GDP-L-galactose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7078" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__L__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDYLATE__45__SYNTHASE__45__RXN" name="Pseudouridylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rluD ) or ( rsuA ) or ( rluF ) or ( rluE ) or ( rluB ) or ( rluC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 23S rRNA pseudouridine synthase ) or ( 16S rRNA pseudouridine synthase ) or ( 23S rRNA pseudouridine synthase ) or ( 23S rRNA pseudouridine synthase ) or ( 23S rRNA pseudouridine synthase ) or ( 23S rRNA pseudouridine synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.70</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7773" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sakuranetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7079" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__DELTA__45__ISOM__45__RXN" name="Dodecenoyl-CoA &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( fadB ) or ( fadJ ) or ( MFP-a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-3, delta2-enoyl-CoA isomerase ) or ( MFP III ) or ( MFP II ) or ( dodecenoyl-CoA &amp;delta;-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase ) or ( FadJ monomer ) or ( MFP a )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation III (unsaturated, odd number)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__DELTA3__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7777" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ponciretin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.75</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7080" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SALICYLATE__45__1__45__MONOOXYGENASE__45__RXN" name="Salicylate 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahG ) or ( nahW ) or ( salA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( salicylate 1-hydroxylase )</html:p>
<html:p>SUBSYSTEM: naphthalene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__110" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__285__45__RXN" name="3&apos;&apos;-deamino-3&apos;&apos;-oxonicotianamine reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ZmDMAS1 ) or ( OsDMAS1 ) or ( hvDMAS1 ) or ( TaDMAS1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2&apos;-deoxymugineic acid phytosiderophore biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.285</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7228" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7227" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCUROISOM__45__RXN" name="Glucuronate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( uxaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hexuronide and hexuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide and D-glucuronate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GFPT1 ) or ( Gfpt1 ) or ( GFA1 ) or ( glmS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamine:fructose-6-phosphate amidotransferase I ) or ( glutamine:fructose 6-phosphate amidotransferase subunit ) or ( glucosamine-6-phosphate synthase subunit ) or ( GlmS )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.16</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__HYDRAT__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( fadB ) or ( fadJ ) or ( maoC ) or ( MFP-a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MFP I ) or ( MFP III ) or ( MFP II ) or ( dodecenoyl-CoA &amp;delta;-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase ) or ( FadJ monomer ) or ( putative ring-cleavage enzyme of phenylacetate degradation ) or ( MFP a )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTATE__45__REDUCTASE__45__NADH__45__RXN" name="Orotate reductase (NADH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pyrDB and pyrK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotate dehydrogenase, electron transfer subunit and dihydroorotate dehydrogenase, catalytic subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R362__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ntnD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrotoluene degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__702" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__703" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__PEROXIDASE__45__RXN" name="glutathione peroxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPX2 ) or ( GPX1 ) or ( GPX3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione peroxidase 2 subunit ) or ( glutathione peroxidase 1 subunit ) or ( glutathione peroxidase 3 subunit )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.9</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXI__45__RXN" name="Lactoylglutathione lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gloA ) or ( gloA ) or ( glo1 ) or ( gloA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxalase I monomer ) or ( GloA ) or ( glyoxalase I ) or ( glyoxalase I monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.5</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__4__46__99__46__5__45__RXN" name="Glycine dehydrogenase (cyanide-forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hcnC and hcnA and hcnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydrogen cyanide synthase HcnB subunit and hydrogen cyanide synthase HcnA subunit and hydrogen cyanide synthase HcnC subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4573" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4568" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4573" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4568" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__28" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At1g19640 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosyl L-methionine:jasmonic acid carboxyl methyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: jasmonic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.141</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__734" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__306" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG24 ) or ( LBR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( lamin B receptor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LCARNCOALIG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( caiC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: carnitine degradation I</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.-</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CARNITINYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__13" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis VI</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__329" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__71__45__RXN" name="Delta24(24-1)-sterol reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.71</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_57222428__45__ERGOSTATETRAENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERGOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TSA__45__REDUCT__45__RXN" name="2-hydroxy-3-oxopropionate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( garR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.60</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( adhE ) or ( adhE ) or (  ) or ( ADH2 ) or ( aad ) or ( ADH1 ) or (  ) or ( adhP ) or ( ADH1B ) or ( ADH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( AdhE ) or ( alcohol dehydrogenase ) or ( NA ) or ( NA ) or ( alcohol dehydrogenase I subunit ) or ( NA ) or ( NA ) or ( alcohol dehydrogenase &amp;beta; subunit ) or ( alcohol dehydrogenase II subunit )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: acetoin degradation</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to ethanol II</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: acetylene degradation</html:p>
<html:p>SUBSYSTEM: ethanol degradation</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to ethanol I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__87__45__RXN" name="N-carbamoyl-L-amino-acid hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hyuC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-carbamoyl-L-amino-acid hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.87</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Carbamoyl__45__L__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__2__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__20" name="Magnesium chelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CHLH and CHLD and CHLI ) or ( CHLD and GUN5 and CH42 ) or ( bchI and bchD and bchH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( magnesium chelatase subunit I and magnesium chelatase subunit H and magnesium chelatase subunit D ) or ( magnesium chelatase subunit D and magnesium chelatase subunit H and magnesium chelatase subunit I ) or ( magnesium-chelatase 129 kDa subunit and bchD and BchI )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.6.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: MG__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MG__43__2" stoichiometry="1"/>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MG__45__PROTOPORPHYRIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__318" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ERG26 ) or ( H105E3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-3 sterol dehydrogenase ) or ( NAD(P)-dependent steroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4702" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4581" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__317" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL ) or ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase ) or ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4580" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4702" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__319" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD17B7 ) or ( ERG27 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 3-keto sterol reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4581" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__314" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD17B7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4578" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__METHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CREATINASE__45__RXN" name="Creatinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( creA ) or ( creA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( creatinase subunit )</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CREATINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__313" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 3&amp;beta;-HSD/D1 ) or ( ERG26 ) or ( 3&amp;beta;-HSD/D2 ) or ( H105E3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( C-3 sterol dehydrogenase ) or ( NA ) or ( NAD(P)-dependent steroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4577" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4578" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__316" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL ) or ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase ) or ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4579" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4580" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Carnitine O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Crat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.7</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__ACETYLCARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__315" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL ) or ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase ) or ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__METHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4579" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__3__46__14__45__RXN" name="Abscisic-aldehyde oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AAO3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( abscisic aldehyde oxidase subunit )</html:p>
<html:p>SUBSYSTEM: abscisic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.14</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__692" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__693" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R603__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: dibenzo-p-dioxin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__925" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__923" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2KETO__45__4METHYL__45__PENTANOATE__45__DEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bfmBAA and bfmBAB and pdhD and bfmBB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-keto-isovalerate dehydrogenase component &amp;alpha; subunit and lipoamide acyltransferase component subunit and dihydrolipoyl dehydrogenase component subunit and 2-keto-isovalerate dehydrogenase component &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMDECARB__45__RXN" name="Diaminopimelate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lysA ) or ( AT5G11880 ) or ( lysA ) or ( AT3G14390 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diaminopimelate decarboxylase subunit ) or ( NA ) or ( LysA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis II</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis VI</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis III</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.20</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TETRATHIOOX__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: tetrathionate oxidation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__14" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__504" name="phytospingosine-1-P phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LCB3 ) or ( YSR3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.91</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHTYOSPHINGOSINE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARALKYLAMINE__45__DEHYDROGENASE__45__RXN" name="Aralkylamine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aralkylamine dehydrogenase &amp;beta; subunit and aralkylamine dehydrogenase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.99.4</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__25" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sgpp1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingosine-1-phosphate phosphatase 1 )</html:p>
<html:p>SUBSYSTEM: sphingosine and sphingosine-1-phosphate metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3DJ__45__11366" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SPHINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__310" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL ) or ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase ) or ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4575" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__311" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL ) or ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase ) or ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4575" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4576" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__312" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL ) or ( ERG25 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase ) or ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: zymosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4576" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4577" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6682" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Bx3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indolin-2-one monooxygenase )</html:p>
<html:p>SUBSYSTEM: DIBOA / DIMBOA biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6361" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6362" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6681" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Bx2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indole monooxygenase )</html:p>
<html:p>SUBSYSTEM: DIBOA / DIMBOA biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6361" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6685" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Bx6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-oxoglutarate-dependent dioxygenase )</html:p>
<html:p>SUBSYSTEM: DIBOA / DIMBOA biosynthesis</html:p>
<html:p>SUBSYSTEM: benzoxazinoid glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6365" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6367" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITRAMALATE__45__LYASE__45__RXN" name="Citramalate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of citramalyl-S-ACP lyase and subunit of citramalate-ACP transferase and subunit of citramalate lyase ACP )</html:p>
<html:p>SUBSYSTEM: glutamate degradation VIII (to propionate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VI (to pyruvate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__CITRAMALATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6683" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Bx4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyindolin-2-one monooxygenase )</html:p>
<html:p>SUBSYSTEM: DIBOA / DIMBOA biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6362" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6364" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINB2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( linB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-hexachlorocyclohexane degradation</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_245__45__DNOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="_25__45__DDOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6684" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Bx5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( HBOA monooxygenase )</html:p>
<html:p>SUBSYSTEM: DIBOA / DIMBOA biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6364" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6365" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OH__45__BENZALDEHYDE__45__DEHYDROG__45__NADP__43____45__RXN" name="Benzaldehyde dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: m-cresol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__OH__45__BENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1781" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sst-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fructan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.99</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__KESTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IPPISOM__45__RXN" name="Isopentenyl-diphosphate &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( IDI1 ) or ( IPP1 ) or ( IDI2 ) or ( IPP2 ) or ( IDI1 ) or ( idi )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( isopentenyl-diphosphate delta-isomerase 2 ) or ( NA ) or ( isopentenyl-diphosphate delta-isomerase 1 ) or ( isopentenyl diphosphate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__54" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-6 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HEXAPRENYL__45__6__45__METHOXY__45__14__45__BENZOQUINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HEXAPRENYL__45__3__45__METHYL__45__6__45__METHOXY__45__14__45__BENZ" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLOSE__45__KINASE__45__RXN" name="Allose kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( alsK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: D-allose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.55</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALLOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LEUCINE__45__23__45__AMINOMUTASE__45__RXN" name="Leucine 2,3-aminomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: leucine degradation II</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2041" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__323" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4187" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__320" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EBP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-&amp;beta;-HYDROXYSTEROID-&amp;delta;(8),&amp;delta;(7)-ISOMERASE )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR24 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 24-dehydrocholesterol reductase precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.72</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__133__45__RXN" name="1D-myo-inositol-trisphosphate 6-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( at5g16760 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis II (via Ins(1,3,4)P3)</html:p>
<html:p>SUBSYSTEM: superpathway of lipid-dependent phytate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.134</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__505" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GEISSOSCHIZINE__45__DEHYDROGENASE__45__RXN" name="Geissoschizine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ajmaline and sarpagine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.36</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_421__45__DEHYDROGEISSOSCHIZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GEISSOSCHIZINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7708" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO8 ) or ( ARO9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic amino acid aminotransferase I ) or ( aromatic amino acid aminotransferase II )</html:p>
<html:p>SUBSYSTEM: methionine degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PHE</html:p>
<html:p>SIDE: PHENYL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__146__45__RXN" name="(Iso)eugenol O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IEMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( IEMT1 subunit )</html:p>
<html:p>SUBSYSTEM: volatile cinnamoic ester biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.146</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOEUGENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOMETHYLEUGENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7706" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH5 ) or ( SFA1 ) or ( ADH1 ) or ( ADH4 ) or ( ADH3 ) or ( ADH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase V subunit ) or ( S-(hydroxymethyl)glutathione dehydrogenase subunit ) or ( alcohol dehydrogenase I subunit ) or ( alcohol dehydrogenase IV subunit ) or ( alcohol dehydrogenase III subunit ) or ( alcohol dehydrogenase II subunit )</html:p>
<html:p>SUBSYSTEM: methionine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7036" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7037" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7703" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NAD/NADH phosphorylation and dephosphorylation</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7704" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-keto-3-methylvalerate decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: methionine degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7036" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7700" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH5 ) or ( SFA1 ) or ( LePAR2 ) or ( LePAR1 ) or ( ADH1 ) or ( ADH4 ) or ( ADH3 ) or ( PAR ) or ( ADH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase V subunit ) or ( S-(hydroxymethyl)glutathione dehydrogenase subunit ) or ( NA ) or ( NA ) or ( alcohol dehydrogenase I subunit ) or ( alcohol dehydrogenase IV subunit ) or ( alcohol dehydrogenase III subunit ) or ( NA ) or ( alcohol dehydrogenase II subunit )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation III</html:p>
<html:p>SUBSYSTEM: phenylethanol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7035" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCEROLTRANSI__45__RXN" name="Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mdoB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerol transferase I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.20</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="1"/>
      <speciesReference species="__124__MDO__45__D__45__Glucoses__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__MDO__45__6__45__Glycerophospho__45__D__45__Glucoses__124__" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__OXIDASE__45__RXN" name="Choline oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( codA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline oxidase subunit )</html:p>
<html:p>SUBSYSTEM: choline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.17</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINC__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( linC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-hexachlorocyclohexane degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.-.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_25__45__DDOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_25__45__DICHLOROHYDROQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__72" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bciA ) or ( DVR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.75</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIVINYL__45__PROTOCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MONO__45__VINYL__45__PROTOCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__ENDO__45__HYDROXYCINEOLE__45__DEHYDROGENASE__45__RXN" name="6-endo-hydroxycineole dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 1,8-cineole degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.241</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__791" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__790" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPDEHYRHAMREDUCT__45__RXN" name="dTDP-4-dehydrorhamnose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfbD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.133</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__RHAMNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN5F9__45__56" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( padB2 ) or ( padB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phthalate 3,4-dihydrodiol dehydrogenase ) or ( phthalate 3,4-dihydrodiol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: phthalate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__45__45__DIHYDROXYCYCLOHEXA__45__162__45__DIENE__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__635" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1761" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( scnC and scnA and scnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiocyanate hydrolase &amp;alpha; subunit and thiocyanate hydrolase &amp;beta; subunit and thiocyanate hydrolase &amp;gamma; subunit )</html:p>
<html:p>SUBSYSTEM: thiocyanate degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.5.8</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HSCN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBONYL__45__SULFIDE" stoichiometry="1"/>
      <speciesReference species="OH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__C__45__PALMITOYLTRANSFERASE__45__RXN" name="Serine C-palmitoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LCB1 and LCB2 ) or ( LCB2 ) or ( LCB1 ) or (  ) or ( Sptlc3 and Sptlc2 and Sptlc1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine palmitoyltransferase subunit LCB1 and serine palmitoyltransferase subunit LCB2 ) or ( serine palmitoyltransferase ) or ( serine palmitoyltransferase ) or ( NA ) or ( serine palmitoyltransferase, long chain base subunit 2 and serine palmitoyltransferase, long chain base subunit 3 and serine palmitoyltransferase, long chain base subunit 1 )</html:p>
<html:p>SUBSYSTEM: ceramide biosynthesis</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.50</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PALMITYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROSPHINGANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTASE__45__RXN" name="Lactase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LCT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lactase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.108</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7710" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SBEI ) or ( SBEII )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( starch branching enzyme I ) or ( starch branching enzyme II )</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7711" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CER10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.38</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__132__45__RXN" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( precorrin-6B (C5,15) methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.132</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__679" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__686" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7712" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( idh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: reductive TCA cycle I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__66" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Chl G ) or ( G4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( chlorophyll synthetase )</html:p>
<html:p>SUBSYSTEM: chlorophyll cycle</html:p>
<html:p>SUBSYSTEM: chlorophyll a biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.62</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTYL__45__PYROPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="CHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLOROPHYLL__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="VITEXIN__45__BETA__45__GLUCOSYLTRANSFERASE__45__RXN" name="Vitexin &amp;beta;-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vitexin and detivatives biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.105</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VITEXIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VITEXIN__45__2__45__O__45__BETA__45__D__45__GLUCOSIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMINOPIMEPIM__45__RXN" name="Diaminopimelate epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dapF ) or ( dapF ) or (  ) or ( dapF ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis II</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis VI</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LL__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLOROMALERED__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( clcE ) or ( tcbF ) or ( tfdFI ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maleylacetate reductase ) or ( maleylacetate reductase subunit ) or ( maleylacetate reductase subunit ) or ( maleylacetate reductase )</html:p>
<html:p>SUBSYSTEM: 3,5-dichlorocatechol degradation</html:p>
<html:p>SUBSYSTEM: 1,4-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__CHLOROMALEYLACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CL__45__" stoichiometry="1"/>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOAMYL__45__RXN" name="Isoamylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLPUTRESCINE__45__DEACETYLASE__45__RXN" name="Acetylputrescine deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aphA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylpolyamine amidohydrolase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.62</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R62__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__5__45__IMIDAZOLE_CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__54" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PINOSYLVIN__45__SYNTHASE__45__RXN" name="Pinosylvin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDSTS3 ) or ( PDSTS1 ) or ( PDSTS2 ) or ( PnI ) or (  ) or ( PnL ) or ( STS1 ) or ( STS2 ) or ( pSP-54 ) or ( PSS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit PDSTS3 ) or ( subunit PDSTS1 ) or ( subunit PDSTS2 ) or ( subunit PnI ) or ( subunit stilbene synthase ) or ( subunit PnL ) or ( subunit STS1 ) or ( subunit STS2 ) or ( subunit pSP-54 ) or ( subunit PSS1 )</html:p>
<html:p>SUBSYSTEM: pinosylvin metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.146</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CINNAMOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__438" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOLALDREDUCT__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fucO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-1,2-propanediol oxidoreductase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of glycol metabolism and degradation</html:p>
<html:p>SUBSYSTEM: ethylene glycol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R461__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( atrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: atrazine degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ACETALD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATRAZINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__801" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8899" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: alliin degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINOACRYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8898" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( alliin lyase ) or ( ALLASA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: alliin degradation</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9269" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9273" stoichiometry="1"/>
      <speciesReference species="_2__45__AMINOACRYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__99" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA20ox2 ) or ( GA20ox ) or ( GA20ox3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase ) or ( gibberellin 20-oxidase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__120" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__84" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLCROTONYL__45__COA__45__CARBOXYLASE__45__RXN" name="Methylcrotonyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MCCB and MCCA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methylcrotonyl-CoA carboxylase &amp;beta; subunit and 3-methylcrotonyl-CoA carboxylase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PFRUCTPHOS__45__RXN" name="6-phosphofructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or ( pfkA ) or ( pfkA ) or ( pfkA ) or ( pfkB ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( 6-phosphofructokinase-1 monomer ) or ( NA ) or ( 6-phosphofructokinase subunit ) or ( 6-phosphofructokinase-2 monomer ) or ( NA ) or ( NA ) or ( 6-phosphofructokinase subunit )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: glycolysis IV (plant cytosol)</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__142__45__RXN" name="Chitobiosyldiphosphodolichol &amp;beta;-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.142</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NN__45__DIACETYLCHITOBIOSYLDIPHOSPHODOLICHO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__MANNOSYLCHITOBIO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SCYLLO__45__INOSAMINE__45__KINASE__45__RXN" name="Scyllo-inosamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.65</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1105" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__180" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__93" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT5g63580 ) or ( AT3g50210 ) or ( AT3g19010 ) or ( At2g44800 ) or ( AT5g63590 ) or ( FLS ) or ( At1g49390 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavonol synthase ) or ( flavonol synthase ) or ( flavonol synthase ) or ( flavonol synthase ) or ( flavonol synthase ) or ( flavonol synthase ) or ( flavonol synthase )</html:p>
<html:p>SUBSYSTEM: flavonol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.23</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROKAEMPFEROL__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__90" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5107" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nudI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrimidine deoxynucleoside triphosphate pyrophosphohydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2301" name="taurine:2-oxoglutarate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: taurine degradation III</html:p>
<html:p>SUBSYSTEM: superpathway of taurine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.55</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFOACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5108" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nudK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleotide-sugar hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4441" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PsTP ) or ( TSase ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalose phosphorylase subunit ) or ( trehalose phosphorylase subunit ) or ( trehalose phosphorylase subunit )</html:p>
<html:p>SUBSYSTEM: trehalose degradation V</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.231</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BADH__45__RXN" name="Betaine-aldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( betB ) or ( gbsA ) or ( betB ) or ( gbsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( betaine aldehyde dehydrogenase ) or ( BetB ) or ( betaine aldehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: choline degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis I (Gram-negative bacteria)</html:p>
<html:p>SUBSYSTEM: choline-O-sulfate degradation</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis III (plants)</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis II (Gram-positive bacteria)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPH__45__RXN" name="Phosphoglycolate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( gph )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycolate phosphatase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: photorespiration</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.18</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__67" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4444" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4G19380 ) or ( fao1 ) or ( fao2 ) or ( AT3G23410 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( long-chain fatty alcohol oxidase ) or ( long-chain fatty alcohol oxidase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;omega;-oxidation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__FATTY__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SYDDEHYD__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tsaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TsaD )</html:p>
<html:p>SUBSYSTEM: 4-toluenesulfonate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__SULFOBENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__257" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGEN__45__BRANCH__45__RXN" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5100" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pinE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( e14 prophage; site-specific DNA recombinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.99.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__DNA__45__Segments__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__DNA__45__Segment__45__in__45__Reverse__45__Orientations__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENODEAMIN__45__RXN" name="Adenosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( add ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__MG__45__PROTOPORPHYRIN__45__METHYLESTER__45__SYN" name="Magnesium-protoporphyrin O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchM ) or ( CHLM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis I</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.11</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MG__45__PROTOPORPHYRIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MG__45__PROTOPORPHYRIN__45__MONOMETHYL__45__ESTER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5101" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nemA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-ethylmaleimide reductase, FMN-linked )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.-.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ETHYLMALEIMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__903" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R321__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.83</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__642" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__643" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__807" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lpqX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lpqX )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD1G__45__69</html:p>
<html:p>SIDE: TREHALOSE__45__6P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__83" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__69" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__768" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__808" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lpqX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lpqX )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD1G__45__69</html:p>
<html:p>SIDE: TREHALOSE__45__6P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__105" stoichiometry="1"/>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__69" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__771" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__809" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lpqX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lpqX )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD1G__45__69</html:p>
<html:p>SIDE: TREHALOSE__45__6P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__106" stoichiometry="1"/>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__69" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__772" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLT_TO_2__45__KETOGLUTARATE_COF_RXN" name="GLT_TO_2-KETOGLUTARATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARABISOM__45__RXN" name="L-arabinose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( araA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-arabinose isomerase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__RIBULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8893" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cad )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( clavulanate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: clavulanate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9260" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9261" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UREIDOGLYCOLATE__45__LYASE__45__RXN" name="Ureidoglycolate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( allA ) or (  ) or ( DAL3 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ureidoglycolase ) or ( ureidoglycolate urea-lyase subunit ) or ( NA ) or ( ureidoglycolate urea-lyase )</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation in plants</html:p>
<html:p>SUBSYSTEM: superpathway of allantoin degradation in yeast</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate III</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: allantoin degradation to glyoxylate I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.3</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R606__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dxnA2 and dxnA1 ) or ( tecA4 and tecA2 and tecA3 and tecA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dioxin dioxygenase &amp;alpha; subunit and dioxin dioxygenase &amp;beta; subunit ) or ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit )</html:p>
<html:p>SUBSYSTEM: dibenzofuran degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__926" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__927" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8890" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( abfD ) or (  ) or ( Msed_1220 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybutyryl-CoA dehydratase subunit ) or ( 4-hydroxybutyryl-CoA dehydratase subunit ) or ( vinylacetyl-CoA &amp;Delta;-isomerase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: succinate fermentation to butyrate</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__226" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5124" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-D-galactose:(glucosyl)lipopolysaccharide-1,6-D-galactosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.44</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__935" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__936" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2208" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G24100 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UGT74B1 )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from homomethionine</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.195</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYLTHIOPROPYLHYDROXAMIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYLTHIOPROPYL__45__DESULFO__45__GLUCOSINOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8889" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( abfT ) or ( cat2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxybutyrate CoA-transferase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: succinate fermentation to butyrate</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="_4__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5123" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipopolysaccharide core biosynthesis protein )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__934" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__935" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2207" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At4g13770 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYP83A1 )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from homomethionine</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="_3__45__METHYLTHIOPROPANALDOXIME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7546" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8887" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ginsenoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9249" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9250" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5122" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipopolysaccharide core biosynthesis protein; heptosyl transferase III )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__933" stoichiometry="1"/>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__934" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2209" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtST5c ) or ( AtST5b )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( desulfoglucosinolate sulfotransferase ) or ( desulfoglucosinolate sulfotransferase )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from homomethionine</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.-</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PAP</html:p>
<html:p>SIDE: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYLTHIOPROPYL__45__DESULFO__45__GLUCOSINOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYLTHIOPROPYL__45__GLUCOSINOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5121" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipopolysaccharide core biosynthesis; phosphorylation of core heptose )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__932" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__933" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8885" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PNA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ginsenoside biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9240" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5127" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( waaU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipopolysaccharide core biosynthesis; heptosyl transferse IV; probably hexose transferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__938" stoichiometry="1"/>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__939" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8058" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: artemisinin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7560" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7561" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5126" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose:(glucosyl)LPS &amp;alpha;-1,2-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__937" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__938" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8883" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SGT3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: steroidal glycoalkaloid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9215" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9214" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2206" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At1g16410 ) or ( At1g16400 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYP79F1 ) or ( CYP79F2 )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from homomethionine</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMOMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYLTHIOPROPANALDOXIME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2205" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BCAT4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: homomethionine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.-</html:p>
<html:p>SIDE: __124__2__45__Oxo__45__Acids__124__</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
      <speciesReference species="_2__45__OXO__45__5__45__METHYLTHIOPENTANOIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMOMETHIONINE" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5125" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-D-glucose:(glucosyl)LPS &amp;alpha;-1,3-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.73</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__936" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__937" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8884" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SGT3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: steroidal glycoalkaloid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__L__45__RHAMNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9212" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENZRXN__45__141__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aad )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTANAL" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2202" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MAM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylthioalkylmalate synthase )</html:p>
<html:p>SUBSYSTEM: homomethionine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__2__45__METHYLTHIOETHYLMALIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULP3EPIM__45__RXN" name="ribulose phosphate 3-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rpe ) or ( rpe ) or ( rpe ) or ( rpe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: ribitol degradation</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation II</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2201" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BCAT4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: homomethionine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.-</html:p>
<html:p>SIDE: __124__2__45__Oxo__45__Acids__124__</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8071" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT2G20610 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from tryptophan</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7547" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1861" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LXULRU5P__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ulaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-xylulose 5-phosphate 3-epimerase )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-lyxose degradation</html:p>
<html:p>SUBSYSTEM: L-ascorbate degradation, anaerobic</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__XYLULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__RIBULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__141__45__RXN" name="N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG14 and ALG13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine: dolichyl diphosphate N-acetylglucosamine, N-acetylglucosamine transferase Alg14p subunit and UDP-N-acetylglucosamine: dolichyl diphosphate N-acetylglucosamine, N-acetylglucosamine transferase Alg13p subunit )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.141</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__190" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NN__45__DIACETYLCHITOBIOSYLDIPHOSPHODOLICHO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R123__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( atzC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-isopropylammelide isopropylaminohydrolase subunit )</html:p>
<html:p>SUBSYSTEM: atrazine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ISOPROPYLAMMELIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOPROPYLAMINE" stoichiometry="1"/>
      <speciesReference species="CYANURIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__76__45__RXN" name="Taxane 10-&amp;beta;-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( taxane 10&amp;beta;-hydroxylase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: taxol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.76</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAXA__45__42011__45__DIEN__45__5__45__ALPHA__45__YL__45__ACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__BETA__45__HYDROXYTAXA__45__42011__45__DIEN__45__5__45__ALPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8079" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fbiC ) or ( cofH and cofG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1 and 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2 )</html:p>
<html:p>SUBSYSTEM: factor 420 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXALATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__7602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8882" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SGT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: steroidal glycoalkaloid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9217" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9216" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8078" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cofD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( LPPG:Fo 2-phospho-L-lactate transferase subunit )</html:p>
<html:p>SUBSYSTEM: factor 420 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: GMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7601" stoichiometry="1"/>
      <speciesReference species="CPD__45__7602" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
      <speciesReference species="__124__Factor__45__420__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8073" name="heme d biosynthesis" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( katE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( KatE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEME_D" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5120" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.58</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__930" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__932" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__3__46__7__45__RXN" name="Succinate-citramalate CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__CITRAMALATE" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__627" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8872" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450 monooxygenase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vanilla biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXYBENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
      <speciesReference species="CPD__45__7616" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5114" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( serB ) or ( PSP ) or ( Psph )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of sulfate assimilation and cysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8873" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( OMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vanilla biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7616" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VANILLIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8875" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SGT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: steroidal glycoalkaloid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9217" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9213" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5118" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-heptose:LPS heptosyl transferase I )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
      <speciesReference species="KDO2__45__LIPID__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__929" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXKIN__45__RXN" name="Pyridoxal kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdxY ) or ( pdxK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal kinase 2 ) or ( PdxK )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__46__45__RXN" name="1,2-diacylglycerol 3-&amp;beta;-galactosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MGD2 ) or ( MGD3 ) or ( MGD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-galactose:DAG galactosyltransferase ) or ( UDP-galactose:DAG galactosyltransferase ) or ( UDP-galactose:DAG galactosyltransferase )</html:p>
<html:p>SUBSYSTEM: glycolipid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.46</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__D__45__Galactosyl__45__12__45__diacyl__45__glycerols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNCARBAMTRANSFER__45__RXN" name="Ornithine carbamoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OTC ) or ( argF ) or ( argF ) or ( ARG3 ) or ( arcB ) or ( OTC ) or ( arcB ) or (  ) or ( argI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ArgF ) or ( ArgF ) or ( ornithine carbamoyltransferase ) or ( ArcB ) or ( ornithine carbamoyltransferase subunit ) or ( NA ) or ( NA ) or ( ArgI )</html:p>
<html:p>SUBSYSTEM: citrulline degradation</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II (from arginine)</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: arginine degradation V (arginine deiminase pathway)</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2441" name="Trans-aconitate 2-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tam )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-aconitate methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.144</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__225" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MONOMETHYL__45__ESTER__45__OF__45__TRANS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8082" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP93E1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6948" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7608" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8081" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cofE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( F420-0:&amp;gamma;-glutamyl ligase subunit )</html:p>
<html:p>SUBSYSTEM: factor 420 polyglutamylation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="CPD__45__7607" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OX__45__COENZYME__45__F420" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8080" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cofE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( F420-0:&amp;gamma;-glutamyl ligase subunit )</html:p>
<html:p>SUBSYSTEM: factor 420 polyglutamylation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10333" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7607" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R482__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AB094498 ) or ( AF216282 ) or ( AF216283 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis IV (from glycine)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.157</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8086" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7610" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7612" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8084" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP93E1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7610" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8871" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 4HBS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vanilla biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COUMARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXYBENZALDEHYDE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8089" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AAO2 ) or ( AAO1 ) or ( AAO3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase subunit ) or ( AO1 ) or ( abscisic aldehyde oxidase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CINNAMALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__674" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8088" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AAO2 ) or ( AAO1 ) or ( AAO3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase subunit ) or ( AO1 ) or ( abscisic aldehyde oxidase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8087" name="&amp;gamma;-F420-2:&amp;alpha;-L-glutamate ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cofF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="OX__45__COENZYME__45__F420" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCITRATE__45__SYNTHASE__45__RXN" name="Homocitrate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hcs ) or ( LYS21 ) or ( nifV ) or ( LYS20 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( homocitrate synthase ) or ( NA ) or ( homocitrate synthase )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis V</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.14</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( udk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KYNURENINE__45__3__45__MONOOXYGENASE__45__RXN" name="Kynurenine 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BNA4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.9</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4461" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pgpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glgX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDINEKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( udk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2222" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AOP2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from homomethionine</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYLSULFINYLPROPYL__45__GLUCOSINOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PROPENYL__45__GLUCOSINOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2223" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AOP3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from homomethionine</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYLSULFINYLPROPYL__45__GLUCOSINOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXYPROPYL__45__GLUCOSINOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8091" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AAO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AO1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7616" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8090" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AAO2 ) or ( AAO3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase subunit ) or ( abscisic aldehyde oxidase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7614" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7615" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8093" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AAO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AO1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANIAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8094" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AAO2 ) or ( AAO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase subunit ) or ( AO1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7620" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7619" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5141" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dkgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.91</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__703" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__702" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8851" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gpgS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosyl-3-phosphoglycerate synthase subunit )</html:p>
<html:p>SUBSYSTEM: glucosylglycerate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: G3P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9189" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__12__46__1__46__1__45__RXN" name="trithionate hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.12.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__552" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
      <speciesReference species="S2O3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8852" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gpgP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glucosylglycerate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9189" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8853" name="Sepiapterin reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SPR ) or ( CT0609 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sepiapterin reductase subunit ) or ( sepiapterin reductase subunit )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.153</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8854" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SPR ) or ( CT0609 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sepiapterin reductase subunit ) or ( sepiapterin reductase subunit )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__LACTOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8855" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( taxoid 14&amp;beta;-hydroxylase )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: taxol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_10__45__BETA__45__HYDROXYTAXA__45__42011__45__DIEN__45__5__45__ALPH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9194" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8857" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BAPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: taxol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CPD__45__9207</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9207" stoichiometry="1"/>
      <speciesReference species="BACCATIN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__9203" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8859" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DBNTBT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: taxol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: BENZOYLCOA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
      <speciesReference species="CPD__45__9203" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8718" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOENOLPYRUVATE__45__MUTASE__45__RXN" name="Phosphoenolpyruvate mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fom1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fosfomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__235" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8023" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phytoene desaturase subunit )</html:p>
<html:p>SUBSYSTEM: trans-lycopene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7408" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8024" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phytoene desaturase subunit )</html:p>
<html:p>SUBSYSTEM: trans-lycopene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7408" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__98" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8022" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ZDS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;zeta;-CAROTENE DESATURASE )</html:p>
<html:p>SUBSYSTEM: trans-lycopene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.30</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__98" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NEUROSPORENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__75" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-6 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.13.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HEXAPRENYL__45__3__45__METHYL__45__6__45__METHOXY__45__14__45__BENZ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HEXAPRENYL__45__3__45__METHYL__45__5__45__HYDROXY__45__6__45__METHOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETCAPR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N6-acetyllysine aminotransferase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.-</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__567" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__6__45__ACETAMIDOCAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NANK__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nanK ) or ( nanK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylmannosamine kinase subunit ) or ( N-acetylmannosamine kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: N-acetylneuraminate and N-acetylmannosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.60</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__99__46__15__45__RXN" name="(1,4)-&amp;alpha;-D-glucan 1-&amp;alpha;-D-glucosylmutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( treY ) or ( treY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOOLIGOSYLTREHALOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UMPKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PYR6 ) or ( pyrH ) or ( pyrH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UMP/CMP kinase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DARAB5PISOM__45__RXN" name="Arabinose-5-phosphate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gutQ ) or ( kdsD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-arabinose 5-phosphate isomerase ) or ( D-arabinose 5-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARABINOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__81" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FMO3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dimethylaniline monooxygenase (n-oxide forming) 3 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2743" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTALDEHYD__45__RXN" name="Histidinol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hisD ) or ( hisD ) or ( HDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( HisD ) or ( histidinol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.23</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTIDINAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__82" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( INMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indolethylamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.49</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3183" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8849" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mgs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannosylglycerate synthase subunit )</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GLYCERATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__O__45__ALPHA__45__MANNOSYL__45__D__45__GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSINE__45__2__45__MONOOXYGENASE__45__RXN" name="Lysine 2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( davB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-lysine monooxygenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.13.12.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINOPENTANAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8848" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9169" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8847" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( nbaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 2-nitrobenzoate nitroreductase subunit )</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation II</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9168" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9169" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOGENTISATE__45__12__45__DIOXYGENASE__45__RXN" name="Homogentisate 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HGD ) or ( hmgA ) or ( hmgA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homogentisate dioxygenase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.5</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8846" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nbaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2-nitrobenzoate degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9169" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8845" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__MUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9167" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8842" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrotoluene degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8017" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trzC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: melamine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7400" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYANURIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrotoluene degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9164" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9165" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8016" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( triA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( melamine deaminase subunit )</html:p>
<html:p>SUBSYSTEM: melamine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7399" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7400" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8840" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrotoluene degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9150" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9164" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8015" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( triA ) or ( trzA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( melamine deaminase subunit ) or ( s-triazine hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: melamine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7398" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7399" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8014" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( REF1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ferulate and sinapate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.68</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SINAPALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SINAPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8035" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coumarin biosynthesis (via 2-coumarate)</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__459" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7417" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GABATRANSAM__45__RXN" name="4-aminobutyrate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGA1 ) or ( puuE ) or ( gabT ) or ( gabT ) or ( ABAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 4-aminobutyrate aminotransferase ) or ( 4-aminobutyrate aminotransferase monomer ) or ( 4-aminobutyrate transaminase subunit ) or ( 4-aminobutyrate aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation I</html:p>
<html:p>SUBSYSTEM: glutamate degradation IX (via 4-aminobutyrate)</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation III</html:p>
<html:p>SUBSYSTEM: glutamate degradation III (via 4-aminobutyrate)</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__4__46__1__46__11__45__RXN" name="L-erythro-3,5-diaminohexanoate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( kdd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-erythro-3,5-diaminohexanoate dehydrogenase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 1.4.1.11</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1067" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__159" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__83" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A4 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2744" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8837" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cnbD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 1-chloro-4-nitrobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9161" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9160" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8836" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cnbCb and cnbCa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-amino-5-chlorophenol 1,6-dioxygenase &amp;beta; subunit and 2-amino-5-chlorophenol 1,6-dioxygenase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: 1-chloro-4-nitrobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9161" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8839" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cnbZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__MUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8720" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R465__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trzA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( s-triazine hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: deethylsimazine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__805" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__806" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8838" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cnbZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 1-chloro-4-nitrobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9160" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9162" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8833" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cnbA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 1-chloro-4-nitrobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9154" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9155" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8832" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrotoluene degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9147" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9148" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__2__46__7__45__RXN" name="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--lysine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( murE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: peptidoglycan biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.7</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
      <speciesReference species="UDP__45__AA__45__GLUTAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__209" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8835" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cnbB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 1-chloro-4-nitrobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9156" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9158" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__121" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cysS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-cysteine : 1 D-myo-inositol 2-amino-2-deoxy-&amp;alpha;-D-glucopyranoside ligase large subunit and L-cysteine : 1 D-myo-inositol 2-amino-2-deoxy-&amp;alpha;-D-glucopyranoside ligase small subunit )</html:p>
<html:p>SUBSYSTEM: mycothiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__0" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__120" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8834" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cnbA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 1-chloro-4-nitrobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9155" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9156" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8026" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( &amp;beta;-OHase 2 ) or ( crtS ) or ( &amp;beta;-OHase 1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( &amp;beta;-ring hydroxylase subunit )</html:p>
<html:p>SUBSYSTEM: astaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: zeaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7409" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__130" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8025" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( &amp;beta;-OHase 2 ) or ( crtS ) or ( &amp;beta;-OHase 1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( &amp;beta;-ring hydroxylase subunit )</html:p>
<html:p>SUBSYSTEM: astaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: zeaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__129" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7409" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8831" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrotoluene degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9148" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9150" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8028" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CrtL-e ) or ( LCYe )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lactucaxanthin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__115" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7414" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__OXYGENASE__45__RXN" name="Myo-inositol oxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MIOX4 ) or ( MIOX1 ) or ( MIOX2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-glucuronate biosynthesis (from myo-inositol)</html:p>
<html:p>PROTEIN_CLASS: 1.13.99.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSHTRAN__45__RXN" name="Glutathione transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSTA1 ) or ( GSTA2 ) or ( GSTA2 and GSTA1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione S-transferase A1 subunit ) or ( glutathione S-transferase A2 subunit ) or ( glutathione S-transferase A2 subunit and glutathione S-transferase A1 subunit ) or ( glutathione transferase subunit )</html:p>
<html:p>SUBSYSTEM: glutathione-mediated detoxification</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>SIDE: HX</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RX" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HX" stoichiometry="1"/>
      <speciesReference species="__124__S__45__Substituted__45__Glutathione__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIARYLPROPANE__45__PEROXIDASE__45__RXN" name="Diarylpropane peroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lipC ) or ( lipA ) or ( lipB ) or ( lipE ) or ( lipD ) or ( lipG ) or ( lipF ) or ( lipI ) or ( lipH ) or ( lipJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( lignin peroxidase A ) or ( lignin peroxidase B ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_12__45__BIS34__45__DIMETHOXYPHENYLPROPANE__45__13__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VERATRALDEHYDE" stoichiometry="1"/>
      <speciesReference species="CPD__45__5702" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8042" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CRTISO ) or ( CRTISO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7496" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__114" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5194" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mraW )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosyl-dependent methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Methyl__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8040" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LUT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NEUROSPORENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7422" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5192" name="Lysine 2,3-aminomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yjeK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysine 2,3-aminomutase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1032" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8046" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AF138959 ) or ( kcs12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: artemisinin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7554" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5190" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mltB ) or ( mltF ) or ( mltA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( membrane-bound lytic murein transglycosylase B ) or ( membrane-bound lytic murein transglycosylase F ) or ( membrane-bound lytic murein transglycosylase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1174" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1176" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1175" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__45____45__LIMONENE__45__6__45__MONOOXYGENASE__45__RXN" name="(-)-limonene 6-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SM12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: (4R)-carvone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.48</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4886" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10051" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG1P__45__URIDYLTRANS__45__RXN" name="UDP-N-acetylglucosamine pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( QRI1 ) or ( glmU ) or ( UAP ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( GlmU ) or ( NA ) or ( UDP-N-acetylglucosamine pyrophosphorylase subunit )</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.23</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8828" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrotoluene degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__701" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9146" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8827" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2,6-dinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9143" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CPD__45__9144" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8826" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2,6-dinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9142" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9143" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8825" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2,6-dinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9133" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9142" stoichiometry="1"/>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8829" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrotoluene degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9146" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9147" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8820" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dntAd and dntAa and dntAb and dntAc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dinitrotoluene dioxygenase ferredoxin component and 2,4-dinitrotoluene dioxygenase reductase component and 2,4-dinitrotoluene dioxygenase oxygenase &amp;alpha; component and 2,4-dinitrotoluene dioxygenase oxygenase &amp;beta; component )</html:p>
<html:p>SUBSYSTEM: 2,4-dinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9132" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9134" stoichiometry="1"/>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__28__45__RXN" name="Phenylethanolamine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PNMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylethanolamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.28</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLETHANOLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__METHYLPHENYLETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8039" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( &amp;beta;-OHase 1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-ring hydroxylase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7419" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7420" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8038" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CrtL-b ) or ( LYC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NEUROSPORENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7419" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8037" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: coumarin biosynthesis (via 2-coumarate)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7418" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COUMARIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8036" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coumarin biosynthesis (via 2-coumarate)</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.21</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7417" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7418" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8824" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dntG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2,4-dinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9137" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__41__45__RXN" name="Bis(5&apos;-nucleosyl)-tetraphosphatase (symmetrical)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( apaH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diadenosine tetraphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.41</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__P4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8823" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dntD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trihydroxytoluene oxygenase subunit )</html:p>
<html:p>SUBSYSTEM: 2,4-dinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9136" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9137" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ERYTH4PDEHYDROG__45__RXN" name="Erythrose-4-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( epd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Epd )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.72</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHRONATE__45__4P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5187" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ybjI ) or ( yigB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FMN phosphatase ) or ( FMN phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8821" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dntB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2,4-dinitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9134" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="CPD__45__9135" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5184" name="Phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( malP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maltodextrin phosphorylase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8050" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP71AV1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: artemisinin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7554" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7556" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5183" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( malZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8051" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP71AV1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: artemisinin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7556" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7557" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5186" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yfbT ) or ( yqaB ) or ( ybiV ) or ( yigL ) or ( yidA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sugar phosphatase ) or ( fructose-1-phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8052" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT2G20610 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from homomethionine</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.-</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7546" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="_3__45__METHYLTHIOPROPYLHYDROXAMIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5185" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yieH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8053" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: artemisinin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7557" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7558" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5180" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ispU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of undecaprenyl diphosphate synthase )</html:p>
<html:p>SUBSYSTEM: di-trans,poly-cis-undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.31</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8054" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT2G20610 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glucosinolate biosynthesis from phenylalanine</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7545" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLACETOTHIOHYDROXIMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8055" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: artemisinin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7558" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7559" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TROPINONE__45__REDUCTASE__45__RXN" name="Tropinone reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( DURTROPR II ) or ( trII ) or ( sTRII )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tropinone reductase (TR-II) ) or ( tropinone reductase (TR-II) ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: calystegine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.236</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TROPINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOTROPINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PQQ_TO_CPD__45__104_COF_RXN" name="PQQ_TO_CPD-104_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PQQ" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__104" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5182" name="maltodextrin phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( malP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maltodextrin phosphorylase monomer )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8056" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: artemisinin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7559" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7560" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATEORTHOPHOSPHATE__45__DIKINASE__45__RXN" name="Pyruvate,phosphate dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdk1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate orthophosphate dikinase )</html:p>
<html:p>SUBSYSTEM: C4 photosynthetic carbon assimilation cycle</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5181" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( malS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOHEXAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__62" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AOX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__61" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP2A6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 2A6 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R218__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__336" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__337" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8815" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: nitrobenzene degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BENZENE__45__NO2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYAMINOBENZENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R581__45__RXN" name="Alkylmercury lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( merB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phenylmercury acetate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__901" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="HG__43__2" stoichiometry="1"/>
      <speciesReference species="BENZENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8814" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nbzAa and nbzAc and nbzAb and nbzAd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxygenaseNBZ&amp;alpha; and ferredoxinNBZ and oxygenaseNBZ&amp;beta; and reductaseNBZ )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__NITROTOLUENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="_4__45__METHYLCATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__71__45__RXN" name="Phosphatidyl-N-methylethanolamine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.71</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__405" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__160" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8816" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation VIII</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7682" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8819" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxygenase2NT&amp;beta; and ferredoxin2NT and oxygenase2NT&amp;alpha; and reductase2NT )</html:p>
<html:p>SUBSYSTEM: 2-nitrotoluene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__NITROTOLUENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="CPD__45__111" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RHAMNISOM__45__RXN" name="L-rhamnose isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rhaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-rhamnose isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of fucose and rhamnose degradation</html:p>
<html:p>SUBSYSTEM: rhamnose degradation</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RHAMNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RHAMNULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8818" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( amnA and amnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-aminophenol-1,6-dioxygenase &amp;alpha; subunit and 2-aminophenol-1,6-dioxygenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: nitrobenzene degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINOPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="H2NTPEPIM__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( folX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroneopterin triphosphate 2&apos;-epimerase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.-.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROMONAPTERIN__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R468__45__RXN" name="cyanuric acid amidohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trzD ) or ( atzD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyanurate amidohydrolase ) or ( cyanurate amidohydrolase subunit )</html:p>
<html:p>SUBSYSTEM: cyanurate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of atrazine degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.15</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYANURIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__809" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLATE__45____45__COA__45__LIGASE__45__RXN" name="Cholate--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( baiB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BaiB )</html:p>
<html:p>SUBSYSTEM: cholate degradation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.7</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLATE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8811" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cephamycin C biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of penicillin, cephalosporin and cephamycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9124" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9125" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8810" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cmcH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cephamycin C biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of penicillin, cephalosporin and cephamycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.7</html:p>
<html:p>SIDE: CARBAMOYL__45__P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEACETYLCEPHALOSPORIN__45__C" stoichiometry="1"/>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9124" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8813" name="all-trans-hexaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDSS2 and PDSS1 ) or ( sds1 ) or ( hepT and hepS ) or ( COQ1 ) or ( ispB ) or ( hexs-b and hexs-a ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decaprenyl diphosphate synthase subunit 1 and decaprenyl diphosphate synthase subunit 2 ) or ( solanesyl diphosphate synthase ) or ( heptaprenyl diphosphate synthase component 1 and heptaprenyl diphosphate synthase component 2 ) or ( hexaprenyl diphosphate synthase subunit ) or ( NA ) or ( hexaprenyl diphosphate synthase component A and hexaprenyl diphosphate synthase component B ) or ( solanesyl diphosphate synthase monomer )</html:p>
<html:p>SUBSYSTEM: octaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: decaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of plastoquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: all trans undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: heptaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: dodecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: nonaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: tridecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: hexaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.33</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIENOYLCOAREDUCT__45__RXN" name="2,4-dienoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fadH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="T2__45__DECENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="T2__45__C4__45__DECADIENYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8812" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cephamycin C biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of penicillin, cephalosporin and cephamycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9125" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9123" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9935" name="mannosylfructose-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mfpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: mannosylfructose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.246</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: FRUCTOSE__45__6P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10683" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8800" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( deoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosine 5&apos;-monophosphate recycling</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ADENINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__15__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9934" name="loliose synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lolS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.247</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10682" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9933" name="biflaviolin synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( sco1207 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10679" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10681" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8801" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( E2b2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosine 5&apos;-monophosphate recycling</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__15__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__RIBULOSE__45__15__45__P2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9932" name="biflaviolin synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( sco1207 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10679" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10680" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXII__45__RXN" name="Hydroxyacylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glo2 ) or ( yeiG ) or ( gloB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( glyoxalase II )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9106" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDSS2 and PDSS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( decaprenyl diphosphate synthase subunit 1 and decaprenyl diphosphate synthase subunit 2 )</html:p>
<html:p>SUBSYSTEM: decaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: all trans undecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: dodecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: tridecaprenyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SOLANESYL__45__PYROPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9610" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4401" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nudC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH pyrophosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="NMNH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9930" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRAHYD__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10679" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__803" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pad1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylacrylate decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__674" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1092" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9104" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: xylan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.24</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_14__45__BETA__45__D__45__XYLANS" stoichiometry="1"/>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="_14__45__BETA__45__D__45__XYLANS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__802" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pad1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylacrylate decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COUMARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1075" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__801" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pad1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylacrylate decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FERULIC__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1072" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8807" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( cat1 ) or ( ASCT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate VI</html:p>
<html:p>SUBSYSTEM: acetate formation from acetyl-CoA III (succinate)</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate V</html:p>
<html:p>SUBSYSTEM: succinate fermentation to butyrate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__ISOPROPYLMALDEHYDROG__45__RXN" name="3-isopropylmalate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( leuB ) or ( leuB ) or ( MJ0720 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( LeuB ) or ( &amp;beta;-isopropylmalate dehydrogenase subunit ) or ( 3-isopropylmalate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.85</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__D__45__THREO__45__HYDROXY__45__3__45__CARBOXY__45__ISOCAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8808" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( lysDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-lysine &amp;epsilon;-dehydrogenase ) or ( L-lysine 6-dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation VIII</html:p>
<html:p>PROTEIN_CLASS: 1.4.1.18</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8809" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( penDE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of penicillin, cephalosporin and cephamycin biosynthesis</html:p>
<html:p>SUBSYSTEM: penicillin K biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.164</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CPD__45__195</html:p>
<html:p>SIDE: CPD__45__196</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__196" stoichiometry="1"/>
      <speciesReference species="ISOPENICILLIN__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
      <speciesReference species="CPD__45__9122" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9939" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine/spermine N1-acetyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: spermine and spermidine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N1__45__ACETYLSPERMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLITACONATE__45__DELTA__45__ISOMERASE__45__RXN" name="Methylitaconate &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mii )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-methylitaconate &amp;Delta;-isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation III</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2CH2__45__3CH3__45__SUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYLMAL__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8805" name="2-hydroxypropyl-CoM lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xecA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxypropyl-CoM lyase subunit )</html:p>
<html:p>SUBSYSTEM: propylene degradation</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.23</html:p>
<html:p>SIDE: __124__CoM__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__12__45__EPOXYPROPANE" stoichiometry="1"/>
      <speciesReference species="__124__CoM__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__S__45__HYDROXYPROPYL__45__COM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__20__46__99__46__1__45__RXN" name="Arsenate reductase (donor)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( arrA and arrB ) or ( arrA and arrB ) or ( arrA and arrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( respiratory arsenate reductase large subunit and respiratory arsenate reductase small subunit ) or ( respiratory arsenate reductase small subunit and respiratory arsenate reductase large subunit ) or ( respiratory arsenate reductase large subunit and respiratory arsenate reductase small subunit )</html:p>
<html:p>SUBSYSTEM: arsenate reduction (respiratory)</html:p>
<html:p>PROTEIN_CLASS: 1.20.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARSENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__763" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8806" name="Alkene monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aamB and aamF and aamA and aamE and aamD and aamC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alkene monooxygenase reductase subunit and alkene monooxygenase coupling/effector subunit and alkene monooxygenase ferredoxin subunit monomer and alkene monooxygenase oxygenase component &amp;gamma; subunit and alkene monooxygenase oxygenase component &amp;beta; subunit and alkene monooxygenase oxygenase component &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: propylene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.69</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__12__45__EPOXYPROPANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9936" name="mannosylfructose-phosphate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mfppA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: mannosylfructose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.79</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10683" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10684" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEYLACETOACETATE__45__ISOMERASE__45__RXN" name="Maleylacetoacetate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( maiA ) or ( MAAI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( maleylacetoacetate isomerase subunit )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METBALT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( metB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MetB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.48</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__SUCCINYL__45__L__45__HOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLOROBENDDH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tecB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( dichlorobenzene cis-dihydrodiol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: 1,4-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_14__45__DICHLOROBENZENE__45__DIHYDRODIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_36__45__DICHLOROCATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDASE__45__RXN" name="Ceramidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Asah1 ) or ( Asah3 ) or ( Asah2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acylsphingosine amidohydrolase 1 ) or ( N-acylsphingosine amidohydrolase (alkaline ceramidase) 3 ) or ( N-acylsphingosine amidohydrolase 2 )</html:p>
<html:p>SUBSYSTEM: sphingosine and sphingosine-1-phosphate metabolism</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.23</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ceramides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="SPHINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TEICHOICSYN1__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tagO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: teichoic acid (poly-glycerol) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: CPD__45__9646</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__D__45__GLUCOSAMINYLDIPHOSPHO__45__UNDECAPRE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9922" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: 4-nitrophenol degradation II</html:p>
<html:p>SUBSYSTEM: resorcinol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__CISCIS__45__MUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5199" name="guanosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NP ) or ( deoD ) or ( deoD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase subunit ) or ( DeoD ) or ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__57__45__RXN" name="Phosphatidyl-myo-inositol &amp;alpha;-mannosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pimA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol &amp;alpha;-mannosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.57</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__MYO__45__INOSITOL__45__2__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__25__45__RXN" name="Triphosphoribosyl-dephospho-CoA synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( citG ) or ( mdcB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2&apos;-(5&apos;-phosphoribosyl)-3&apos;-dephospho-CoA biosynthesis I (citrate lyase)</html:p>
<html:p>SUBSYSTEM: 2&apos;-(5&apos;-phosphoribosyl)-3&apos;-dephospho-CoA biosynthesis II (malonate decarboxylase)</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.25</html:p>
<html:p>SIDE: ADENINE</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="_2__45__5__45__TRIPHOSPHORIBOSYL__45__3__45__DEPHOSPHO__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CREATININASE__45__RXN" name="Creatininase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( crn ) or ( crnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( creatininase subunit ) or ( creatininase subunit )</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CREATININE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CREATINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__19__45__RXN" name="Ent-kaurene synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( KS1 ) or ( KSB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ent-kaurene synthase ) or ( ent-kaurene synthase B )</html:p>
<html:p>SUBSYSTEM: superpathway of GA12 biosynthesis</html:p>
<html:p>SUBSYSTEM: ent-kaurene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.19</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ENT__45__COPALYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__128" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP cyclohydrolase I" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AY069920 ) or ( GCH1 ) or ( AF489530 ) or ( folE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP cyclohydrolase I subunit ) or ( GTP cyclohydrolase subunit ) or ( GTP cyclohydrolase I subunit ) or ( GTP cyclohydrolase I monomer )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CONIFERIN__45__BETA__45__GLUCOSIDASE__45__RXN" name="Coniferin &amp;beta;-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( AF072736 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( glucosidase subunit I and glucosidase subunit II )</html:p>
<html:p>SUBSYSTEM: coniferin metabolism</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.126</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1777" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CONIFERYL__45__ALCOHOL" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9929" name="dihydroorotate dehydrogenase class I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pyr4 ) or ( URA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotate dehydrogenase subunit ) or ( dihydroorotate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9926" name="alditol oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( xyoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alditol oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.41</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alditols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldoses__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__SYNTHASE__45__RXN" name="Hydroxymethylglutaryl-CoA synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( hmgS ) or ( HMGCS1 ) or ( HMGCS2 ) or ( BAP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( HmgS ) or ( hydroxymethylglutaryl-CoA synthase, cytoplasmic ) or ( hydroxymethylglutaryl-CoA synthase, mitochondrial precursor ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.10</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NMNNUCLEOSID__45__RXN" name="NMN nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling (plants)</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.14</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: RIBOSE__45__5P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE__45__DECARBOXYLASE__45__RXN" name="Pyruvate decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC1 ) or ( PDC5 ) or ( PDC6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate decarboxylase 1 subunit ) or ( pyruvate decarboxylase 2 subunit ) or ( pyruvate decarboxylase 3 subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOASYN__45__RXN" name="long-chain-fatty-acid--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LACS7 ) or ( alkK ) or ( LACS6 ) or ( fadD ) or ( ACSL1 ) or ( fadK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( FadD ) or ( long-chain-fatty-acid--CoA ligase 1 ) or ( short chain acyl-CoA synthetase monomer )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUTP__45__PYROP__45__RXN" name="dUTP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dut ) or ( nudI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dut ) or ( pyrimidine deoxynucleoside triphosphate pyrophosphohydrolase )</html:p>
<html:p>SUBSYSTEM: pyrimidine deoxyribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.23</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOLACT__45__RXN" name="Gluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gnl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gluconolactonase subunit )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis II</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3521" name="undecaprenyl phosphate-L-Ara4FN transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( arnC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( undecaprenyl phosphate-L-Ara4FN transferase )</html:p>
<html:p>SUBSYSTEM: biosynthesis of  4-amino-4-deoxy-L-arabinose-modified lipid A</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: CPD__45__9646</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9646" stoichiometry="1"/>
      <speciesReference species="UDP__45__L__45__ARA4__45__FORMYL__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__888" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__3__45__CYANOALANINE__45__SYNTHASE__45__RXN" name="L-3-cyanoalanine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SPIol;Bsas3;1 ) or (  ) or ( At3g61440 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-cyano-L-alanine synthase ) or ( subunit of &amp;beta;-cyano-L-alanine synthase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cyanide detoxification</html:p>
<html:p>SUBSYSTEM: cyanide degradation</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCN" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="CPD__45__603" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__ARGININE__45__DEIMINASE__45__RXN" name="Protein-arginine deiminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 2552184 ) or ( PADI2 ) or ( PADI1 ) or ( PADI4 ) or ( PADI3 ) or ( PADI6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( peptidylarginine deiminase II ) or ( peptidylarginine deiminase I ) or ( peptidylarginine deiminase IV ) or ( peptidylarginine deiminase III ) or ( peptidylarginine deiminase type VI )</html:p>
<html:p>SUBSYSTEM: protein citrullination</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.15</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__L__45__Arginines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIENELACHYDRO__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbE ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( dienelactone hydrolase )</html:p>
<html:p>SUBSYSTEM: 1,4-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__2__45__CHLORO__45__4__45__CARBOXYMETHYLENEBUT__45__2__45__E" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__CHLOROMALEYLACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPSUGARHYDRO__45__RXN" name="UDP-sugar diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ushA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.45</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__UDP__45__sugar__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="__124__Alpha__45__D__45__aldose__45__1__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9913" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ccaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-dienelactone hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: chlorosalicylate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__CL__45__5__45__OXO__45__2__45__5__45__DIH__45__FURAN__45__2__45__ACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9912" name="Salicylate 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( salA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( salicylate 1-hydroxylase )</html:p>
<html:p>SUBSYSTEM: chlorosalicylate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10576" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9152" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__821" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( putA ) or ( PRODH ) or ( put1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused PutA transcriptional repressor / proline dehydrogenase / pyrroline-5-carboxylate dehydrogenase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9911" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: C30 botryococcene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9910" name="Benzaldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit of benzaldehyde dehydrogenase )</html:p>
<html:p>SUBSYSTEM: 3-chlorotoluene degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.28</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10660" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3486" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9916" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RsM2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: mangrove triterpenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10667" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9915" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RsM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: mangrove triterpenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERMANICOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9914" name="Salicylate 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( salA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( salicylate 1-hydroxylase )</html:p>
<html:p>SUBSYSTEM: chlorosalicylate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10663" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9152" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLESTEROL__45__7__45__ALPHA__45__MONOOXYGENASE__45__RXN" name="Cholesterol 7-&amp;alpha;-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Por and Cyp7a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADPH-cytochrome P450 reductase and cytochrome P450 7A1 )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.17</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__266" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9918" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cpt1a ) or ( Cpt2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine palmitoyltransferase 1a ) or ( carnitine palmitoyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: mitochondrial L-carnitine shuttle pathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.21</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__O__45__Acyl__45__L__45__Carnitines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTDECARBOX__45__RXN" name="Glutamate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gadB ) or ( GAD2 ) or ( GAD1 ) or ( GAD2 ) or ( gadA ) or ( GAD1 ) or ( GAD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate decarboxylase B subunit ) or ( NA ) or ( NA ) or ( glutamate decarboxylase 2 subunit ) or ( glutamate decarboxylase A subunit ) or ( NA ) or ( glutamate decarboxylase 1 subunit )</html:p>
<html:p>SUBSYSTEM: glutamate dependent acid resistance</html:p>
<html:p>SUBSYSTEM: glutamate degradation IV</html:p>
<html:p>SUBSYSTEM: glutamate degradation IX (via 4-aminobutyrate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation III (via 4-aminobutyrate)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.15</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="ribose-phosphate diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( prsA ) or ( prs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR24 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 24-dehydrocholesterol reductase precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.72</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8606" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP__45__ADENYLYLTRANSFERASE__45__RXN" name="ATP adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( APA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.53</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__P4" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__11" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8606" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8607" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__12" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8607" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8608" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__13" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8608" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8609" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__14" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LBR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lamin B receptor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8610" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__15" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8610" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8611" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__111__45__RXN" name="Coniferyl-alcohol glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( UGT72E2 ) or ( UGT72E3 ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: coniferin metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.111</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CONIFERYL__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1777" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__16" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8611" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8612" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__17" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8612" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__18" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( H105E3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P)-dependent steroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8613" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8614" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__19" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD17B7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8614" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4184" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8002" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: trans-lycopene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of carotenoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.32</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__464" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTOENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8005" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RhGT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rose anthocyanin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__591" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7386" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9137" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rubber biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.20</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="__124__Rubbers__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Rubbers__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8006" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RhGT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rose anthocyanin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7386" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7138" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9136" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rubber biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.20</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: DELTA3__45__ISOPENTENYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1028" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8003" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__4__45__HYDROXY__45__D__45__PROLINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1128" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAMKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdxK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PdxK )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8009" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 6&apos;-deoxychalcone metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__57__45__RXN" name="N-methylphosphoethanolamine cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.57</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__406" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__N__45__METHYLETHANOLAMIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tfdC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( chlorocatechol 1,2-dioxygenase subunit )</html:p>
<html:p>SUBSYSTEM: 5-chloro-3-methyl-catechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10616" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10646" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SORB6PDEHYDROG__45__RXN" name="Sorbitol-6-phosphate 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( srlD ) or ( sorD ) or ( srlD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol-6-phosphate dehydrogenase subunit ) or ( NA ) or ( SrlD )</html:p>
<html:p>SUBSYSTEM: sorbitol degradation</html:p>
<html:p>SUBSYSTEM: L-sorbose degradation</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: superpathway of hexitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.140</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SORBITOL__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8008" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AmAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aureusidin synthase )</html:p>
<html:p>SUBSYSTEM: aurone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.21.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7389" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="O__45__CRESOL__45__METHYLCATECHOL__45__RXN" name="Phenol 2-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tomA3 and tomA4 and tomA1 and tomA2 and tomA5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( toluene ortho-monooxygenase TomA5 subunit and toluene ortho-monooxygenase TomA2 subunit and toluene ortho-monooxygenase hydroxylase TomA3 subunit and toluene ortho-monooxygenase hydroxylase TomA1 subunit and toluene ortho-monooxygenase hydroxylase TomA4 subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation to 2-oxopent-4-enoate I (via o-cresol)</html:p>
<html:p>SUBSYSTEM: toluene degradation I (aerobic) (via o-cresol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__109" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__111" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gndA ) or ( gndA ) or ( gnd ) or ( gnd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phophogluconate dehydrogenase subunit ) or ( NA ) or ( Gnd ) or ( 6-phosphogluconate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9904" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( tfdDI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="CPD__45__10653" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9903" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( tfdDI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit )</html:p>
<html:p>SUBSYSTEM: 5-chloro-3-methyl-catechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10651" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9906" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tecA4 and tecA2 and tecA3 and tecA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit )</html:p>
<html:p>SUBSYSTEM: 3-chlorotoluene degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10654" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10655" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9905" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( tfdDI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10652" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9908" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylA and xylM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH-acceptor-reductase subunit of xylene monooxygenase and hydroxylase subunit of xylene monooxygenase )</html:p>
<html:p>SUBSYSTEM: 3-chlorotoluene degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10654" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10659" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9907" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tecB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3-chlorotoluene degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10655" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10616" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9909" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzyl alcohol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: 3-chlorotoluene degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10659" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10660" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__20" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4184" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8617" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__23" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( H105E3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P)-dependent steroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8619" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8620" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__19__46__4__45__RXN" name="Delta(8)-fatty-acid desaturase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AB085690 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;8-fatty-acid desaturase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.19.4</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10693" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__24" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD17B7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8620" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8621" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__21" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8617" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8618" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8619" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__27" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DESMOSTEROL__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__28" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR24 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 24-dehydrocholesterol reductase precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.72</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DESMOSTEROL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9140" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( valA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: validamycin A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9663" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__25" name="Cholestenol &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EBP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-&amp;beta;-HYDROXYSTEROID-&amp;delta;(8),&amp;delta;(7)-ISOMERASE )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8621" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__26" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC5DL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lathosterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.6</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8646" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9144" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( valC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C7-cyclitol kinase )</html:p>
<html:p>SUBSYSTEM: validamycin A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9665" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9667" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8012" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: aurone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7389" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7392" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9145" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( valC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C7-cyclitol kinase )</html:p>
<html:p>SUBSYSTEM: validamycin A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9666" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9668" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8011" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 6&apos;-deoxychalcone metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7390" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8010" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 6&apos;-deoxychalcone metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7391" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__39__45__RXN" name="Glycerol-3-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tagD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate cytidylyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: teichoic acid (poly-glycerol) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.39</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__606" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__11100" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Degs2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase )</html:p>
<html:p>SUBSYSTEM: ceramide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3DJ__45__82" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ceramides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SORBITOL__45__6__45__PHOSPHATASE__45__RXN" name="Sorbitol-6-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sorbitol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.50</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SORBITOL__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN4FS__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of phosphatidylcholine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD4FS__45__1" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GERANIOL__45__DEHYDROGENASE__45__RXN" name="Geraniol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GEDH ) or ( yqhD ) or ( GEDH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NADP-dependent dehydrogenase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: geraniol and geranial biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.183</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANIAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN4FS__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: superpathway of phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.71</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__160" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__470" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC1 ) or ( PDC5 ) or ( PDC6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate decarboxylase 1 subunit ) or ( pyruvate decarboxylase 2 subunit ) or ( pyruvate decarboxylase 3 subunit )</html:p>
<html:p>SUBSYSTEM: acetoin biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9148" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( vldE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: validamycin A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9669" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="VALIDAMYCIN__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9157" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hypoglycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>SIDE: CYS__45__GLY</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9699" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9700" stoichiometry="1"/>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__2__46__29__45__RXN" name="5-dehydro-2-deoxyphosphogluconate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-dehydro-2-deoxyphosphogluconate aldolase )</html:p>
<html:p>SUBSYSTEM: myo-inositol degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.29</html:p>
<html:p>SIDE: DIHYDROXY__45__ACETONE__45__PHOSPHATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__645" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9158" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfbJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-abequose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1078" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__ABEQUOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9159" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfbS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-paratose synthase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-paratose biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-tyvelose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1078" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__36__45__DIDEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN4FS__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( yfbT ) or ( ybiV ) or ( yigL ) or ( yidA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sugar phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase )</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis II (L-gulose pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD4FS__45__5" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD4FS__45__6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DHBDEHYD__45__RXN" name="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( entA ) or ( dhbA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( EntA ) or ( 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: 2,3-dihydroxybenzoate biosynthesis</html:p>
<html:p>SUBSYSTEM: bacillibactin biosynthesis</html:p>
<html:p>SUBSYSTEM: enterobactin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.28</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__DIOH__45__BENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__3__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9162" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BGLU1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dalcochinin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>SIDE: __124__D__45__Glucose__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9677" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__D__45__Glucose__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__9711" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ascF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: CDP-ascarylose biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9756" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9701" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYRIBONUCSYN__45__RXN" name="Phosphoribosylamine--glycine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade5,7 ) or ( purD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Ade5,7 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Dnbglu2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-O--D-apiofuranosyl-(1-6)-&amp;beta;-D-glucopyranosidase )</html:p>
<html:p>SUBSYSTEM: dalpatein and dalnigrein biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CPD__45__9004</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9693" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9710" stoichiometry="1"/>
      <speciesReference species="CPD__45__9004" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9160" name="CDP-abequose epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfbE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-tyvelose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.10</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__36__45__DIDEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9698" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3561" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( caiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: carnitine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CARNITINYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONOBETAINYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PPGPPSYN__45__RXN" name="Guanosine-3&apos;,5&apos;-bis(diphosphate) 3&apos;-pyrophosphohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( spoT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ppGpp biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.7.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE__45__5DP__45__3DP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__21__46__2__45__RXN" name="(S)-cheilanthifoline synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__SCOULERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__CHEILANTHIFOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R145__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mtnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1063" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__84" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9950" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Scp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol carrier protein 2 )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.176</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PROPIONYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7257" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONATE__45__2__45__DEHYDROGENASE__45__RXN" name="Gluconate 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-gluconate dehydrogenase 66.5 kD subunit and D-gluconate dehydrogenase 47.5 kD subunit and D-gluconate dehydrogenase 21.7 kD subunit )</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R202__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xenB ) or ( xenA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: nitroglycerin degradation</html:p>
<html:p>PROTEIN_CLASS: 1.7.3.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__145" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__147" stoichiometry="1"/>
      <speciesReference species="NITRITE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9955" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.105</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Isopropenyl__45__4H__45__hexano__45__lactones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Isopropenyl__45__6__45__oxoheptanoates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9175" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hypoglycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.-</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9739" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9699" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1A0__45__6321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ActVA )</html:p>
<html:p>SUBSYSTEM: actinorhodin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1A0__45__6117" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1A0__45__6119" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1A0__45__6322" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCO5080 ) or ( SCO5092 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ActVA-ORF5 ) or ( ActVB )</html:p>
<html:p>SUBSYSTEM: actinorhodin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: FMN</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>COFACTOR: FMNH2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FMN</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: FMNH2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1A0__45__6119" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1A0__45__6123" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__20__46__4__46__2__45__RXN" name="Methylarsonate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSTO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylarsonate reductase subunit )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: 1.20.4.2</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>SIDE: OXIDIZED__45__GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLARSONATE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLARSONITE" stoichiometry="1"/>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLASPARTATE__45__AMMONIA__45__LYASE__45__RXN" name="Methylaspartate ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylaspartase subunit )</html:p>
<html:p>SUBSYSTEM: glutamate degradation VIII (to propionate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VI (to pyruvate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__THREO__45__3__45__METHYL__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MESACONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCLOEUCALENOL__45__CYCLOISOMERASE__45__RXN" name="Cycloeucalenol cycloisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CPI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cycloeucalenol cycloisomerase )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYCLOEUCALENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OBTUSIFOLIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLPROLYL__45__ISOMERASE__45__RXN" name="Peptidylprolyl isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fkpB ) or ( ppiD ) or ( slyD ) or ( ppiC ) or ( ppiA ) or ( tig ) or ( fklB ) or ( ppiB ) or ( surA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( FKBP-type peptidyl prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase C (rotamase C) ) or ( peptidyl-prolyl cis-trans isomerase A (rotamase A) ) or ( trigger factor; a molecular chaperone involved in cell division ) or ( FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) ) or ( peptidyl-prolyl cis-trans isomerase B (rotamase B) ) or ( peptidyl-prolyl cis-trans isomerase (PPIase) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8625" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISONOCARDICIN__45__SYNTHASE__45__RXN" name="Isonocardicin synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.38</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NOCARDICIN__45__E" stoichiometry="1"/>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISONOCARDICIN__45__A" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERYL__45__ETHER__45__MONOOXYGENASE__45__RXN" name="Glyceryl-ether monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyceryl-ether monooxygenase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.5</html:p>
<html:p>COFACTOR: BIOPTERIN</html:p>
<html:p>COFACTOR: TETRA__45__H__45__BIOPTERIN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__ALKYL__45__SN__45__GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__HYDROXYALKYL__45__SN__45__GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9947" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( limC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carveol dehydrogenase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__260" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10037" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDGALDOL__45__RXN" name="2-dehydro-3-deoxyglucarate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( garL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.20</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__KETO__45__4__45__DEOXY__45__D__45__GLUCARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TARTRONATE__45__S__45__ALD" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__810" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lpqX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lpqX )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD1G__45__69</html:p>
<html:p>SIDE: TREHALOSE__45__6P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__107" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__773" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__69" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__811" name="3-oxoacyl-[acyl-carrier protein] reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lpqX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lpqX )</html:p>
<html:p>SUBSYSTEM: mycolate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of mycolate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD1G__45__69</html:p>
<html:p>SIDE: TREHALOSE__45__6P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE__45__6P" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__774" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__69" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9940" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Paox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal N1-acetylspermine/spermidine oxidase )</html:p>
<html:p>SUBSYSTEM: spermine and spermidine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.11</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__10687</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N1__45__ACETYLSPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10687" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIDH ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.105</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3161" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3141" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9942" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Paox )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal N1-acetylspermine/spermidine oxidase )</html:p>
<html:p>SUBSYSTEM: spermine and spermidine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.11</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__10687</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__568" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10687" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9943" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine/spermine N1-acetyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: spermine and spermidine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__568" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1G__45__186" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mca ) or ( mca )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: mycothiol-mediated detoxification</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD1G__45__0</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1G__45__130" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__185" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__0" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMALDEHYDE__45__TRANSKETOLASE__45__RXN" name="Formaldehyde transketolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxyacetone synthase subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXYACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOSYLPYRIMIDINE__45__NUCLEOSIDASE__45__RXN" name="Ribosylpyrimidine nucleosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rihB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleoside hydrolase 2 (pyrimidine-specific) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__D__45__ribosylpyrimidines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Pyrimidines__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1402" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose 1-phosphokinase )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__15__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1A0__45__6312" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: actinorhodin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1A0__45__6105" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1A0__45__6106" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GART__45__RXN" name="Phosphoribosylglycinamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( purN ) or ( ade8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.2</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1A0__45__6310" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCO5072 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ActVI-ORF1 )</html:p>
<html:p>SUBSYSTEM: actinorhodin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1A0__45__6104" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1A0__45__6105" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1401" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( phnN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosine 5&apos;-monophosphate recycling</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__15__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9188" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ascE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: CDP-ascarylose biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of CDP-3,6-dideoxyhexose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1078" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9756" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1A0__45__6316" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCO5075 ) or ( SCO5073 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ActVI-ORF4 ) or ( ActVI-ORF2 )</html:p>
<html:p>SUBSYSTEM: actinorhodin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: H</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="H" stoichiometry="1"/>
      <speciesReference species="CPD1A0__45__6111" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1A0__45__6112" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1A0__45__6314" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: actinorhodin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1A0__45__6106" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1A0__45__6111" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3542" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nudJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__27__45__RXN" name="1,2-dehydroreticulinium reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: morphine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.27</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_12__45__DEHYDRORETICULINIUM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__RETICULINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULPEPIM__45__RXN" name="L-ribulose-phosphate 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sgbE ) or ( ulaF ) or ( araD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( L-ribulose 5-phosphate 4-epimerase ) or ( L-ribulose 5-phosphate 4-epimerase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-lyxose degradation</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation I</html:p>
<html:p>SUBSYSTEM: L-ascorbate degradation, anaerobic</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__RIBULOSE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
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  <reaction id="RXN0__45__3543" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cof ) or ( nudJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYLPYRIMIDINE__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__HYDROXYMETHYL__45__METHYL__45__PYR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1A0__45__6318" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SCO5081 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ActVA-ORF6 )</html:p>
<html:p>SUBSYSTEM: actinorhodin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1A0__45__6112" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1A0__45__6117" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__742" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( purK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N5-carboxyaminoimidazole ribonucleotide synthase monomer )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.18</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__181" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__743" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( purE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PurE )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: inosine-5&apos;-phosphate  biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__181" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9871" name="Benzoate 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( benA and benB and benC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzoate 1,2-dioxygenase electron transfer subunit and benzoate 1,2-dioxygenase hydroxylase &amp;alpha: subunit and benzoate 1,2-dioxygenase hydroxylase &amp;beta: subunit )</html:p>
<html:p>SUBSYSTEM: 3-chlorobenzoate degradation (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3486" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9872" name="Benzoate 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( benA and benB and benC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( benzoate 1,2-dioxygenase electron transfer subunit and benzoate 1,2-dioxygenase hydroxylase &amp;alpha: subunit and benzoate 1,2-dioxygenase hydroxylase &amp;beta: subunit )</html:p>
<html:p>SUBSYSTEM: 3-chlorobenzoate degradation (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3486" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10619" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9870" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( clcA ) or ( tfdC ) or ( tcbC ) or ( salD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorocatechol 1,2-dioxygenase subunit ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 4-chlorocatechol degradation</html:p>
<html:p>SUBSYSTEM: chlorosalicylate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9152" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__279" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHORISMATEMUT__45__RXN" name="Chorismate mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtCM1 ) or ( tyrA ) or ( pheA ) or ( aroA ) or ( AtCM2 ) or ( CM3 ) or ( aroH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( TyrA ) or ( PheA ) or ( AroA ) or ( NA ) or ( NA ) or ( AroH )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine and tyrosine biosynthesis</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis III</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis I</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PREPHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16ALDOLASE__45__RXN" name="Fructose-bisphosphate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or (  ) or (  ) or (  ) or ( fba ) or (  ) or (  ) or ( fbaB ) or (  ) or ( fbaA ) or ( fba ) or ( fbaA ) or ( fbaB ) or (  ) or ( fba ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosolic fructose-bisphosphate aldolase ) or ( chloroplastic fructose-bisphosphate aldolase ) or ( fructose-1,6-biphosphate aldolase ) or ( chloroplastic fructose-bisphosphate aldolase ) or ( cytosolic fructose-bisphosphate aldolase ) or ( cytosolic fructose-bisphosphate aldolase ) or ( chloroplastic fructose-bisphosphate aldolase ) or ( NA ) or ( fructose-1,6-biphosphate aldolase ) or ( fructose-1,6-biphosphate aldolase ) or ( fructose bisphosphate aldolase monomer ) or ( fructose-1,6-bisphosphate aldolase subunit ) or ( fructose bisphosphate aldolase monomer ) or ( fructose-1,6-bisphosphate aldolase subunit ) or ( NA ) or ( NA ) or ( NA ) or ( fructose bisphosphate aldolase subunit ) or ( cytosolic fructose-bisphosphate aldolase ) or ( chloroplastic fructose-bisphosphate aldolase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: glycolysis IV (plant cytosol)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7607" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( surE ) or (  ) or ( yjjG ) or ( yrfG ) or ( nagD ) or ( ushA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( broad specificity 5&apos;(3&apos;)-nucleotidase and polyphosphatase ) or ( 5&apos;-nucleotidase ) or ( pyrimidine nucleotidase ) or ( purine nucleotidase ) or ( ribonucleotide monophosphatase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7609" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( surE ) or (  ) or ( yjjG ) or ( yrfG ) or ( nagD ) or ( ushA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( broad specificity 5&apos;(3&apos;)-nucleotidase and polyphosphatase ) or ( 5&apos;-nucleotidase ) or ( pyrimidine nucleotidase ) or ( purine nucleotidase ) or ( ribonucleotide monophosphatase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5402" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 2&apos;-dioxygenase &amp;alpha; subunit and tryptophan 2&apos;-dioxygenase &amp;gamma; subunit and tryptophan 2&apos;-dioxygenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.99.3</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5403" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 2&apos;-dioxygenase &amp;alpha; subunit and tryptophan 2&apos;-dioxygenase &amp;gamma; subunit and tryptophan 2&apos;-dioxygenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__INDOLYLGLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__INDOLEGLYOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__REDUCTASE__45__RXN" name="Sulfite reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dsrA and dsrC and dsrB ) or ( asrC and asrB and asrA ) or ( dsrB and dsrA ) or (  ) or ( dsrA and dsrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfite reductase, dissimilatory &amp;gamma; subunit and sulfite reductase, dissimilatory &amp;alpha; subunit and sulfite reductase, dissimilatory &amp;beta; subunit ) or ( dissimilatory sulfite reductase &amp;beta; subunit and dissimilatory sulfite reductase &amp;alpha; subunit and dissimilatory sulfite reductase &amp;gamma; subunit ) or ( sulfite reductase &amp;beta; subunit and sulfite reductase &amp;alpha; subunit and sulfite reductase &amp;gamma; subunit ) or ( NA ) or ( siroheme sulfite reductase, &amp;alpha; subunit and siroheme sulfite reductase, &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of tetrathionate reduction (Salmonella typhimurium)</html:p>
<html:p>SUBSYSTEM: sulfide oxidation III (siroheme sulfite reductase)</html:p>
<html:p>SUBSYSTEM: sulfate reduction III (dissimilatory)</html:p>
<html:p>SUBSYSTEM: superpathway of thiosulfate metabolism (Desulfovibrio sulfodismutans)</html:p>
<html:p>PROTEIN_CLASS: 1.8.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9869" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( salC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( muconate cycloisomerase I )</html:p>
<html:p>SUBSYSTEM: chlorosalicylate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__CL__45__5__45__OXO__45__2__45__5__45__DIH__45__FURAN__45__2__45__ACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CL__45__" stoichiometry="1"/>
      <speciesReference species="CPD__45__10640" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9868" name="Carboxymethylenebutenolidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tfdEI ) or ( clcD ) or ( tcbE ) or ( ccaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dienelactone hydrolase I ) or ( dienelactone hydrolase ) or ( NA ) or ( trans-dienelactone hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: 3-chlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.45</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10608" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9867" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( clcB ) or ( tfdDI ) or ( tcbD ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase )</html:p>
<html:p>SUBSYSTEM: 3-chlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__CL__45__MUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10638" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9866" name="2,4-dichlorophenol 6-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tfdBI ) or ( tfdBII )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dichlorophenol 6-monooxygenase I ) or ( 2,4-dichlorophenol monooxygenase II )</html:p>
<html:p>SUBSYSTEM: 4-chloro-2-methylphenoxyacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.20</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10615" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10616" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( TCS1 ) or ( CCS1 ) or ( CaDXMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( caffeine synthase ) or ( caffeine synthase ) or ( caffeine synthase ) or ( caffeine synthase )</html:p>
<html:p>SUBSYSTEM: caffeine biosynthesis II (via paraxanthine)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.160</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__7__45__DIMETHYLXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__3__45__7__45__TRIMETHYLXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7600" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: caffeine biosynthesis II (via paraxanthine)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_7__45__METHYLXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__7__45__DIMETHYLXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9864" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tfdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dichlorophenoxyacetate dioxygenase )</html:p>
<html:p>SUBSYSTEM: 4-chloro-2-methylphenoxyacetate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLYOX</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10614" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
      <speciesReference species="CPD__45__10615" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9863" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tfdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dichlorophenoxyacetate dioxygenase )</html:p>
<html:p>SUBSYSTEM: 2,4-dichlorophenoxyacetate  degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLYOX</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9009" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
      <speciesReference species="_24__45__DICHLOROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9880" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tecB ) or ( tcbB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 1,2,4-trichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10623" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10622" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9881" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tecA4 and tecA2 and tecA3 and tecA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10627" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10628" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYL__45__PHOSPHATASE__45__RXN" name="aryldialkyl phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( opd ) or ( opd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( organophosphate acid anhydrase )</html:p>
<html:p>SUBSYSTEM: parathion degradation</html:p>
<html:p>SUBSYSTEM: superpathway of parathion degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__63__45__RXN" name="Polyphosphate-glucose phosphotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ppgK ) or ( ppgK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( polyphosphate-dependent glucokinase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.63</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Polyphosphate__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9882" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tecB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10628" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10629" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__661" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cymAb and cymAa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CymAa and CymAb )</html:p>
<html:p>SUBSYSTEM: p-cymene degradation</html:p>
<html:p>SUBSYSTEM: p-cymene degradation to p-cumate</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1001" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1002" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1826" name="starch phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( starch phosphorylase ) or ( starch phosphorylase )</html:p>
<html:p>SUBSYSTEM: starch degradation</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R204__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xenB ) or ( xenA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: nitroglycerin degradation</html:p>
<html:p>PROTEIN_CLASS: 1.7.3.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__144" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="2"/>
      <speciesReference species="CPD__45__147" stoichiometry="1"/>
      <speciesReference species="CPD__45__146" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__662" name="Aryl-alcohol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cymB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CymB )</html:p>
<html:p>SUBSYSTEM: p-cymene degradation</html:p>
<html:p>SUBSYSTEM: p-cymene degradation to p-cumate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.90</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1002" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1003" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1827" name="&amp;beta;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CT-BMY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: starch degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__MALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__663" name="Aryl-aldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cymC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: p-cymene degradation</html:p>
<html:p>SUBSYSTEM: p-cymene degradation to p-cumate</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.29</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1003" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1004" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1828" name="disproportionating enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DPE1 ) or ( dpep )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: starch degradation</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__664" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cmtAd and cmtAb and cmtAc and cmtAa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CmtAd and CmtAb and CmtAa and CmtAc )</html:p>
<html:p>SUBSYSTEM: p-cymene degradation</html:p>
<html:p>SUBSYSTEM: p-cumate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: p-cumate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1004" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1005" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7617" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DES )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__137" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6975" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R230__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( comC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme M biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.272</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__367" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__380" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7619" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6228" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__137" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9878" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbAd and tcbAc and tcbAb and tcbAa ) or ( tecA4 and tecA2 and tecA3 and tecA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorobenzene dioxygenase, ferredoxin component and chlorobenzene dioxygenase, NADH-ferredoxin reductase component and chlorobenzene dioxygenase, terminal oxygenase component, small subunit and chlorobenzene dioxygenase, terminal oxygenase component, large subunit ) or ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit )</html:p>
<html:p>SUBSYSTEM: 1,2-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__DICHLOROBENZENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10624" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__666" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cmtC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: p-cymene degradation</html:p>
<html:p>SUBSYSTEM: p-cumate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: p-cumate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1006" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1007" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1823" name="&amp;alpha;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AMY2 ) or ( AMY1 ) or ( SEX4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: starch degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Large__45__branched__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9877" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbAd and tcbAc and tcbAb and tcbAa ) or ( tecA4 and tecA2 and tecA3 and tecA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorobenzene dioxygenase, ferredoxin component and chlorobenzene dioxygenase, NADH-ferredoxin reductase component and chlorobenzene dioxygenase, terminal oxygenase component, small subunit and chlorobenzene dioxygenase, terminal oxygenase component, large subunit ) or ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit )</html:p>
<html:p>SUBSYSTEM: 1,2,4-trichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_124__45__TCB" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10623" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__665" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cmtB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: p-cymene degradation</html:p>
<html:p>SUBSYSTEM: p-cumate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: p-cumate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.58</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1005" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1006" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1825" name="&amp;alpha;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AMY2 ) or ( AMY1 ) or ( SEX4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: starch degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__668" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cmtE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: p-cymene degradation</html:p>
<html:p>SUBSYSTEM: p-cumate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: p-cumate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ISOBUTYRATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1008" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="OXOPENTENOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9879" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tecB ) or ( tcbB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 1,2-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10626" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1824" name="debranching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( zpu1 ) or ( DBE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: starch degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.41</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Large__45__branched__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__667" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cmtD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: p-cymene degradation</html:p>
<html:p>SUBSYSTEM: p-cumate degradation to 2-oxopent-4-enoate</html:p>
<html:p>SUBSYSTEM: p-cumate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1007" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1008" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9874" name="Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( benD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: 3-chlorobenzoate degradation (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10619" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9152" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7614" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( menE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis II (plants)</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.26</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="O__45__SUCCINYLBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6972" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9873" name="Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( benD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: 3-chlorobenzoate degradation (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10618" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9151" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9876" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: 1,2,4,5-tetrachlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10621" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="CPD__45__10622" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7612" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit PMT )</html:p>
<html:p>SUBSYSTEM: pinosylvin metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__438" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6964" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__3__46__9__45__RXN" name="Secologanin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP72A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.9</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LOGANIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SECOLOGANIN__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9875" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tecA4 and tecA2 and tecA3 and tecA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit )</html:p>
<html:p>SUBSYSTEM: 1,2,4,5-tetrachlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10620" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10621" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7611" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STS2 ) or ( PSS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( subunit STS2 ) or ( subunit PSS1 )</html:p>
<html:p>SUBSYSTEM: pinosylvin metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__503" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6963" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9890" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3,4,6-trichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10636" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10637" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__79__45__RXN" name="cyclopropane-fatty-acyl-phospholipid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cfa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Cfa )</html:p>
<html:p>SUBSYSTEM: cyclopropane fatty acid (CFA) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.79</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phospholipid__45__Olefinic__45__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Phospholipid__45__Cyclopropane__45__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R213__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aksD ) or ( aksE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme B biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__153" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__285" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHBUTYRYL__45__COA__45__EPIM__45__RXN" name="3-hydroxybutyryl-CoA epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( fadB ) or ( fadJ ) or ( MFP-a )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MFP I ) or ( MFP III ) or ( MFP II ) or ( dodecenoyl-CoA &amp;delta;-isomerase, enoyl-CoA hydratase, 3-hydroxybutyryl-CoA epimerase, 3-hydroxyacyl-CoA dehydrogenase ) or ( FadJ monomer ) or ( MFP a )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9893" name="Chloromuconate cycloisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( tfdDII ) or ( clcB ) or ( tfdDI ) or ( tcbD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( dienelactone hydrolase II subunit ) or ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit )</html:p>
<html:p>SUBSYSTEM: 4-chlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.7</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__279" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__CARBOXYMETHYLENEBUT__45__2__45__EN__45__4__45__OLIDE" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9894" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( clcB ) or ( tfdDI ) or ( tcbD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit )</html:p>
<html:p>SUBSYSTEM: 3-chlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10638" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="CPD__45__10608" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R262__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sorE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: L-sorbose degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__531" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__SORBITOL__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9891" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maleylacetate reductase subunit )</html:p>
<html:p>SUBSYSTEM: 3,4,6-trichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10637" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10634" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9892" name="Chloromuconate cycloisomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( salC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( muconate cycloisomerase I )</html:p>
<html:p>SUBSYSTEM: chlorosalicylate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.7</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__279" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__CL__45__5__45__OXO__45__2__45__5__45__DIH__45__FURAN__45__2__45__ACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__963" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( frlB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructoselysine 6-phosphate deglycase monomer )</html:p>
<html:p>SUBSYSTEM: fructoselysine and psicoselysine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSELYSINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( frlD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructoselysine 6-kinase )</html:p>
<html:p>SUBSYSTEM: fructoselysine and psicoselysine degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSELYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSELYSINE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PABSYNMULTI__45__RXN" name="synthesis of p-aminobenzoic acid" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pabB and pabC and pabA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PabB and pabC and PabA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__LYSINE__45__56__45__AMINOMUTASE__45__RXN" name="&amp;beta;-lysine 5,6-aminomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kamE and kamD ) or ( kamE and kamD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysine 5,6-aminomutase &amp;beta; subunit and lysine 5,6-aminomutase &amp;alpha; subunit ) or ( L-&amp;beta;-lysine-5,6-aminomutase &amp;alpha; subunit and L-&amp;beta;-lysine-5,6-aminomutase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 5.4.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__233" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1067" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEYLPYRUVATE__45__ISOMERASE__45__RXN" name="Maleylpyruvate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate degradation</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1070" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__277" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATE__45__DECARBOXYLASE__45__RXN" name="Aconitate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: itaconate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ITACONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLPYRUVATE__45__DECARBOXYLASE__45__RXN" name="Phenylpyruvate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO10 ) or ( PDC1 ) or ( PDC5 ) or (  ) or ( PDC6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-keto-3-methylvalerate decarboxylase subunit ) or ( pyruvate decarboxylase 1 subunit ) or ( pyruvate decarboxylase 2 subunit ) or ( phenylpyruvate decarboxylase ) or ( pyruvate decarboxylase 3 subunit )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation III</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.43</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__961" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mpaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( murein peptide amidase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALA__45__GAMMA__45__D__45__GLU__45__DAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MESO__45__DIAMINOPIMELATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALA__45__GAMMA__45__D__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7626" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: P__45__COUMAROYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2222" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6976" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7629" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6979" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6981" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7628" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP98A6 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6976" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6979" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9887" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( clcD ) or ( tcbE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dienelactone hydrolase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 3,4-dichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10633" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10634" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9886" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( tcbD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit )</html:p>
<html:p>SUBSYSTEM: 3,4-dichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10631" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CL__45__" stoichiometry="1"/>
      <speciesReference species="CPD__45__10633" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7622" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9885" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maleylacetate reductase subunit )</html:p>
<html:p>SUBSYSTEM: 3,4-dichlorocatechol degradation</html:p>
<html:p>SUBSYSTEM: 3,4,6-trichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10634" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__294" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7625" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DES )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__134" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6983" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9884" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( chlorocatechol 1,2-dioxygenase subunit )</html:p>
<html:p>SUBSYSTEM: 3,4-dichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10626" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10631" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7624" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__95" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__134" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9889" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit )</html:p>
<html:p>SUBSYSTEM: 3,4,6-trichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10635" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CL__45__" stoichiometry="1"/>
      <speciesReference species="CPD__45__10636" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7621" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6975" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GIBBERELLIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9888" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tcbC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3,4,6-trichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10622" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10635" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__680" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositolphosphotransferase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: INOSITOL__45__PHOSPHATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MIPC" stoichiometry="1"/>
      <speciesReference species="INOSITOL__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MIP2C" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__ARABINITOL__45__4__45__DEHYDROGENASE__45__RXN" name="D-arabinitol 4-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( atlA ) or ( dalD ) or ( mtlD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: D-arabitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.11</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__355" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__641" name="Quinoline 2-oxidoreductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinoline 2-oxidoreductase &amp;gamma; subunit and quinoline 2-oxidoreductase &amp;beta; subunit and quinoline 2-oxidoreductase &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: 3-methylquinoline degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.17</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__962" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__963" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__642" name="2-hydroxyquinoline 5,6-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 3-methylquinoline degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.16</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__963" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__981" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KDO__45__8PSYNTH__45__RXN" name="2-dehydro-3-deoxyphosphooctonate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kdsA1 ) or ( kdsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-deoxy-8-phosphooctulonate synthase subunit ) or ( 3-deoxy-D-manno-octulosonate 8-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of KDO2-lipid A biosynthesis</html:p>
<html:p>SUBSYSTEM: CMP-KDO biosynthesis II (from D-arabinose 5-phosphate)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.55</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: PHOSPHO__45__ENOL__45__PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARABINOSE__45__5P" stoichiometry="1"/>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KDO__45__8P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__268__45__RXN" name="2-(R)-hydroxypropyl-CoM dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xecD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-(R)-hydroxypropyl-CoM dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: propylene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.268</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__R__45__HYDROXYPROPYL__45__COM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOPROPYL__45__COM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINB1__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( linB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-hexachlorocyclohexane degradation</html:p>
<html:p>PROTEIN_CLASS: 3.8.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__15" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="_245__45__DNOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPIONYL__45__COA_TO_CO__45__A_COF_RXN" name="PROPIONYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREDEHYD__45__RXN" name="Threonine dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tdcB ) or ( ilvA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( TdcB ) or ( IlvA )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: hypoglycin biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I (from threonine)</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.19</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7637" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ndhS and ndhF and ndhM and ndhL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate hydroxylase 50 kD subunit and nicotinate hydroxylase 37 kD subunit and nicotinate hydroxylase 33 kD subunit and nicotinate hydroxylase 23 kD subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of nicotinate degradation</html:p>
<html:p>SUBSYSTEM: nicotinate degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__HYDROXY__45__NICOTINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__116__45__RXN" name="3&apos;-hydroxy-N-methyl-(S)-coclaurine 4&apos;-O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( D29812 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&apos;-hydroxy-N-methylcoclaurine 4&apos;-O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: (S)-reticuline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.116</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__N__45__METHYL__45__S__45__COCLAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__RETICULINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 1-FEH w2 ) or ( 1-FEH w1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: fructan degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.80</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__KESTOTRIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9895" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DCD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dammara-18(28),21-diene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10642" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mshA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: mycothiol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1G__45__1" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9898" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10643" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10644" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7634" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DES )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__134" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6984" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7633" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis II</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.140</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CAFFEOYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CAFFEOYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6982" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6981" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7632" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis II</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.237</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_34__45__DIHYDROXYPHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6982" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9899" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10643" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10645" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7631" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6978" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6981" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7630" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis I</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6976" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6978" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROG__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glpD ) or ( GPD2 ) or ( glpC and glpA and glpB ) or ( AT3g10370 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GlpD ) or ( mitochondrial glycerol-3-phosphate dehydrogenase subunit ) or ( glycerol-3-phosphate dehydrogenase (anaerobic), membrane anchor subunit and glycerol-3-phosphate dehydrogenase (anaerobic), small subunit and glycerol-3-phosphate dehydrogenase (anaerobic), large subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.5.3</html:p>
<html:p>SIDE: UBIQUINOL__45__8</html:p>
<html:p>SIDE: UBIQUINONE__45__8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MORPHINE__45__6__45__DEHYDROGENASE__45__RXN" name="Morphine 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COR1.1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( codeinone reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: morphine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.218</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MORPHINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MORPHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__901" name="Xanthine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AtXDH1 ) or ( xdhB and xdhC and xdhA ) or (  ) or (  ) or ( Xdh ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase ) or ( xanthine dehydrogenase subunit with putative molybdenum cofactor-binding domain and putative xanthine dehydrogenase subunit, FAD-binding domain and putative xanthine dehydrogenase, Fe-S subunit ) or (  ) or ( xanthine dehydrogenase &amp;gamma; subunit and xanthine dehydrogenase &amp;beta; subunit and xanthine dehydrogenase &amp;alpha; subunit ) or ( xanthine oxidase monomer ) or ( xanthine dehydrogenase ) or ( xanthine dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xdhB and xdhC and xdhA ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase subunit with putative molybdenum cofactor-binding domain and putative xanthine dehydrogenase subunit, FAD-binding domain and putative xanthine dehydrogenase, Fe-S subunit ) or ( purine hydroxylase &amp;alpha; subunit and purine hydroxylase &amp;beta; subunit and purine hydroxylase &amp;gamma; subunit and purine hydroxylase &amp;delta; subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1241" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( prmC ) or ( prmB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N5__45__METHYLGLUTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__25__45__RXN" name="S-linalool synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Lis )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: linalool biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8997" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7650" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP93B2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavone synthase II )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis II</html:p>
<html:p>SUBSYSTEM: luteolin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__431" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__80__45__RXN" name="4-hydroxyphenylpyruvate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC1 ) or ( PDC6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate decarboxylase 1 subunit ) or ( pyruvate decarboxylase 3 subunit )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.80</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDRPHENYLAC__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__72__45__RXN" name="Branched-chain-2-oxoacid decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARO10 ) or ( PDC1 ) or ( PDC5 ) or ( THI3 ) or ( PDC6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-keto-3-methylvalerate decarboxylase subunit ) or ( pyruvate decarboxylase 1 subunit ) or ( pyruvate decarboxylase 2 subunit ) or ( keto-isocaproate decarboxylase subunit ) or ( pyruvate decarboxylase 3 subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.72</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLBUT__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7643" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDC1 ) or ( PDC5 ) or ( PDC6 ) or ( kivd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate decarboxylase 1 subunit ) or ( pyruvate decarboxylase 2 subunit ) or ( pyruvate decarboxylase 3 subunit ) or ( &amp;alpha;-ketoisovalerate decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7000" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7644" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( NAD-SDH ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol dehydrogenase subunit ) or ( NA ) or ( sorbitol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: sorbitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7645" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSCHS ) or ( PDCHSX ) or ( SbCHS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PSCHS subunit ) or ( PDCHSX subunit ) or ( SbCHS2 subunit )</html:p>
<html:p>SUBSYSTEM: pinobanksin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CINNAMOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6993" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7647" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chalcone isomerase I ) or ( chalcone isomerase II )</html:p>
<html:p>SUBSYSTEM: pinobanksin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6993" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6991" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7648" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AN3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pinobanksin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.9</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6991" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6992" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_24__45__DIAMINOPENTANOATE__45__DEHYDROGENASE__45__RXN" name="2,4-diaminopentanoate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>PROTEIN_CLASS: 1.4.1.12</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_24DINH2__45__PENTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__299" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEHYDROG__45__RXN" name="Homoserine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( thrA ) or ( metL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ThrA ) or ( MetL )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (by sulfhydrylation)</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: homoserine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine biosynthesis</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.3</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__663" name="inositol phosphorylceramide mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CSG2 and SUR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA and NA )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IPC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MIPC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__43__45__RXN" name="6-phosphogluconate 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glucose degradation (oxidative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.43</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__339" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSPH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CGS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine &amp;gamma;-synthase )</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: CYS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="O__45__PHOSPHO__45__L__45__HOMOSERINE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7660" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G74470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: phytyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7003" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7653" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP93B2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavone synthase II )</html:p>
<html:p>SUBSYSTEM: luteolin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6994" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5734__45__TETRAHYDROXYFLAVONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__621" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dszC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DszC )</html:p>
<html:p>SUBSYSTEM: dibenzothiophene desulfurization</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__942" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__943" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7654" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP71D9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 6,7,4&apos;-trihydroxyisoflavone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3061" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6996" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__622" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dszC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DszC )</html:p>
<html:p>SUBSYSTEM: dibenzothiophene desulfurization</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__943" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__944" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7651" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SHT12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: luteolin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__431" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5734__45__TETRAHYDROXYFLAVONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dszA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dibenzothiophene desulfurization</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__944" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__945" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7652" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SHT12 ) or ( AT5g07990 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( flavonoid 3&apos;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: luteolin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6994" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__624" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dszB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dibenzothiophene desulfurization</html:p>
<html:p>PROTEIN_CLASS: 3.13.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__945" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="CPD__45__946" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7657" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH5 ) or ( SFA1 ) or ( ADH1 ) or ( ADH4 ) or ( ADH3 ) or ( ADH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase V subunit ) or ( S-(hydroxymethyl)glutathione dehydrogenase subunit ) or ( alcohol dehydrogenase I subunit ) or ( alcohol dehydrogenase IV subunit ) or ( alcohol dehydrogenase III subunit ) or ( alcohol dehydrogenase II subunit )</html:p>
<html:p>SUBSYSTEM: valine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7000" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ISOBUTANOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7658" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G74470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: phytyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7002" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7655" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IFS-Tp ) or ( IFS1 ) or ( CYP Ge-8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isoflavone synthase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 6,7,4&apos;-trihydroxyisoflavone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6996" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6997" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7656" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 6,7,4&apos;-trihydroxyisoflavone biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6997" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6998" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGPPHOSPHA__45__RXN" name="Phosphatidylglycerophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( pgpA ) or (  ) or ( pgpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis II</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis I (plastid)</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.27</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BILIVERDIN__45__REDUCTASE__45__RXN" name="Biliverdin reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BLVRA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biliverdin reductase A )</html:p>
<html:p>SUBSYSTEM: heme degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.24</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BILIVERDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIRUBIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7659" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G74470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: phytyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7002" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7003" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1261" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( elaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( binuclear zinc phosphodiesterase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIS__45__P__45__NITROPHENOLPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__194" stoichiometry="1"/>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__LYSINE__45__AMINOTRANSFERASE__45__RXN" name="L-lysine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lat ) or ( lat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( L-lysine 6-aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation VI</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.36</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__2__45__PHOSPHATASE__45__RXN" name="Glycerol-2-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( suhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol monophosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.19</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__536" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__45__45__RXN" name="4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( proD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-hydroxy-&amp;gamma;-carboxymuconate &amp;epsilon;-semialdehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.45</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__87" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__CARBOXY__45__2__45__HYDROXY__45__CISCIS__45__MUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TEICHOICSYN2__45__RXN" name="N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-&amp;beta;-D- mannosaminyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tagA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: teichoic acid (poly-glycerol) biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.187</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__D__45__GLUCOSAMINYLDIPHOSPHO__45__UNDECAPRE" stoichiometry="1"/>
      <speciesReference species="UDP__45__MANNAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__ETCETERA__45__GLUCOSAMINYLDIPHOSPHOUND" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7666" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G74470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7006" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLOROPHYLL__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__MEBUCOA__45__FAD__45__RXN" name="2-methylacyl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( acdH ) or ( Acadsb )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-methyl branched-chain acyl-CoA dehydrogenase subunit ) or ( acyl-CoA dehydrogenase subunit ) or ( 2-methyl branched chain acyl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: 2-methylbutyrate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.12</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__METHYL__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULOSE__45__BISPHOSPHATE__45__CARBOXYLASE__45__RXN" name="Ribulose-bisphosphate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbbM ) or ( rbcS1A and ATCG00490 ) or ( ATCG00490 and rbcS3B ) or ( ATCG00490 and rbcS2B ) or ( ATCG00490 and rbcS1B ) or ( rbcL ) or ( cbbS and cbbL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribulose bisphosphate carboxylase subunit ) or ( RUBISCO small subunit and RUBISCO large subunit ) or ( RUBISCO small subunit and RUBISCO large subunit ) or ( RUBISCO large subunit and RUBISCO small subunit ) or ( RUBISCO small subunit and RUBISCO large subunit ) or ( ribulose bisphosphate carboxylase subunit ) or ( CbbL and CbbS )</html:p>
<html:p>SUBSYSTEM: adenosine 5&apos;-monophosphate recycling</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.39</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__RIBULOSE__45__15__45__P2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDASE__45__YEAST__45__RXN" name="Ceramidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( YDC1 ) or ( YPC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceramidase ) or ( ceramidase )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.23</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phytoceramides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7668" name="Glycogen (starch) synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GYS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen synthase subunit )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis II (from UDP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.11</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7669" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GBE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis II (from UDP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7663" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( G4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorophyll synthetase )</html:p>
<html:p>SUBSYSTEM: chlorophyll a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GERANYLGERANYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7005" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTITOLPDEHYD__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gatD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: galactitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTITOL__45__1__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAGATOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7664" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G74470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7005" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7004" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7665" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G74470 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7004" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7006" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEME__45__OXYGENASE__45__DECYCLIZING__45__RXN" name="Heme oxygenase (decyclizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pbsA1 ) or ( HMOX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heme oxygenase 1 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: heme degradation</html:p>
<html:p>SUBSYSTEM: phycocyanobilin biosynthesis</html:p>
<html:p>SUBSYSTEM: phycoerythrobilin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__MONOXIDE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIVERDINE" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__10__46__2__45__RXN" name="Non-specific protein-tyrosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( wzc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine kinase involved in colanic acid biosynthesis )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.10.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFINOALANINE__45__DECARBOXYLASE__45__RXN" name="Sulfinoalanine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Csad )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfinoalanine decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: taurine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.29</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOTAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRAZIN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pncA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRAZINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRAZINOIC__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7683" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTE5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phytol salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: CDP</html:p>
<html:p>COFACTOR: CTP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CDP</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHYTOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7025" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7682" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtXDH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1804" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 6-SFT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sucrose:fructan 6-fructosyltransferase 49 kDa subunit and sucrose:fructan 6-fructosyltransferase 23 kDa subunit )</html:p>
<html:p>SUBSYSTEM: fructan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.10</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
      <speciesReference species="_1__45__KESTOTRIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="BIFURCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7680" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 3-oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6974" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPRIBOSYLTRAN__45__RXN" name="Adenine phosphoribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( APT1 ) or ( apt ) or ( apt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( Apt )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: adenosine 5&apos;-monophosphate recycling</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.7</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7679" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll cycle</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7016" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLOROPHYLL__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7677" name="Chlorophyllide-a oxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll cycle</html:p>
<html:p>PROTEIN_CLASS: 1.13.12.14</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7015" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7014" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FTRMBARK__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ftr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methyl-coenzyme M oxidation to CO2</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: CPD__45__8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__22" stoichiometry="1"/>
      <speciesReference species="__124__Methanofurans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8" stoichiometry="1"/>
      <speciesReference species="__124__Formyl__45__methanofurans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7678" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.294</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROPHYLL__45__B" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHANOL__45__OXIDASE__45__RXN" name="Methanol oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AOD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol oxidase subunit )</html:p>
<html:p>SUBSYSTEM: methanol oxidation to formaldehyde</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7676" name="Chlorophyllide-a oxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: chlorophyll cycle</html:p>
<html:p>PROTEIN_CLASS: 1.13.12.14</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7015" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__600" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4g35420 ) or ( TT3 ) or ( AT4g33360 ) or ( At1g25460 ) or ( AT4g27250 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroflavonol 4-reductase ) or ( dihydroflavonol 4-reductase ) or ( dihydroflavonol 4-reductase ) or ( dihydroflavonol 4-reductase ) or ( dihydroflavonol 4-reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: leucopelargonidin and leucocyanidin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.219</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__474" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__590" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1801" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fft-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fructan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.100</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__KESTOTRIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NYSTOSE" stoichiometry="1"/>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BUTYRATE__45__KINASE__45__RXN" name="Butyrate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( buk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( butyrate kinase subunit )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate I</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.7</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTYRYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7673" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( G4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorophyll synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__7014" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7013" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1802" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 6G-FFT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fructan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
      <speciesReference species="_1__45__KESTOTRIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
      <speciesReference species="_6G__45__KESTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7674" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( G4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorophyll synthetase )</html:p>
<html:p>SUBSYSTEM: chlorophyll cycle</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PHYTYL__45__PYROPHOSPHATE</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7014" stoichiometry="1"/>
      <speciesReference species="PHYTYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLOROPHYLL__45__B" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__602" name="Leucocyanidin oxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4g22880 ) or ( AT4g22870 ) or ( At2g38240 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anthocyanidin synthase ) or ( anthocyanidin synthase ) or ( anthocyanidin synthase )</html:p>
<html:p>SUBSYSTEM: anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__590" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__591" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1803" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 6-SFT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sucrose:fructan 6-fructosyltransferase 49 kDa subunit and sucrose:fructan 6-fructosyltransferase 23 kDa subunit )</html:p>
<html:p>SUBSYSTEM: fructan biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.10</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="_6__45__KESTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__3__46__12__45__RXN" name="Dihydrobenzophenanthridine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: sanguinarine and macarpine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.12</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSANGUINARINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SANGUINARINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R423__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( camP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxygenating component of camphor 1,2-monooxygenase subunit and NADH oxidase )</html:p>
<html:p>SUBSYSTEM: adamantanone degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__743" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__745" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R231__45__RXN" name="sulfopyruvate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( comD and comE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta; subunit of sulfopyruvate decarboxylase and &amp;alpha; subunit of sulfopyruvate decarboxylase )</html:p>
<html:p>SUBSYSTEM: coenzyme M biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.79</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__380" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFOACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP__45__MANNOSE__45__6__45__DEHYDROGENASE__45__RXN" name="GDP-mannose 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( algD ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: alginate biosynthesis I</html:p>
<html:p>SUBSYSTEM: alginate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.132</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1828" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Homoserine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( metX ) or ( met2 ) or ( metX ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( Met2 ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: homocysteine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (by sulfhydrylation)</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.31</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__667" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SOXA__45__FDENIT__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( soxA and soxB and soxZ and soxC and soxD and soxY and soxX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SoxA and SoxX and SoxC and SoxY and SoxB and SoxD and SoxZ )</html:p>
<html:p>SUBSYSTEM: thiosulfate oxidation II (multienzyme complex)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="2"/>
      <speciesReference species="E__45__" stoichiometry="8"/>
    </listOfProducts>
  </reaction>
  <reaction id="RFFTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rffA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.-</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP__45__D__45__FUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__FORMYLGLUTATHIONE__45__HYDROLASE__45__RXN" name="S-formylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fghA ) or ( frmB ) or ( yeiG ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FghA ) or ( S-formylglutathione hydrolase ) or ( NA ) or ( S-formylglutathione hydrolase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of C1 compounds oxidation to CO2</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation II (glutathione-dependent)</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.12</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__PYRONE__45__46__45__DICARBOXYLATE__45__LACTONASE__45__RXN" name="2-pyrone-4,6-dicarboxylate lactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pmdD ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-pyrone-4,6-dicarboxylate hydrolase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: gallate degradation I</html:p>
<html:p>SUBSYSTEM: methylgallate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.57</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__184" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__185" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHGLYSYN__45__RXN" name="Methylglyoxal synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mgsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylglyoxal synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYCLOHEXANOL__45__DEHYDROGENASE__45__RXN" name="Cyclohexanol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( chnA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cyclohexanol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.245</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYCLOHEXANOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYCLOHEXANONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R125__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( kce )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-keto-5-aminohexanoate cleavage enzyme subunit ) or ( 3-keto,5-aminohexanoate cleavage enzyme subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__159" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__672" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITDEH__45__RXN" name="Isocitrate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HP0027 ) or ( IDH2 ) or ( IDH1 ) or ( icd ) or ( icd ) or ( icd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate dehydrogenase subunit ) or ( isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor ) or ( isocitrate dehydrogenase (NADP) cytoplasmic ) or ( Icd ) or ( isocitrate dehydrogenase (NADP-dependent) ) or ( isocitrate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation I</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: TCA cycle variation II</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6562" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: asparagine degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOSUCCINAMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIND__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( linD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-hexachlorocyclohexane degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>SIDE: OXIDIZED__45__GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
      <speciesReference species="_25__45__DICHLOROHYDROQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="CHLOROHYDROQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PAPS_TO_PAP_COF_RXN" name="PAPS_TO_PAP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCOKINASE__45__RXN" name="Fucokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis II (from L-fucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.52</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__488" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R229__45__RXN" name="2-phosphosulfolactate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( comB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: coenzyme M biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.71</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__366" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__367" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIGLUCO__45__DOCOSANOATE__45__ACETYLATION__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sophorosyloxydocosanoate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIGLUCO__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIGLUCOACETYL__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5466" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
      <speciesReference species="CPD__45__5164" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5165" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5467" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
      <speciesReference species="CPD__45__5165" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__11__45__RXN" name="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtPIS1 ) or ( AtPIS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol synthase ) or ( AtPIS1 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.11</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5468" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
      <speciesReference species="CPD__45__5166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5167" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5469" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5167" stoichiometry="1"/>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5168" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5462" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.132</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__MANNOSYLCHITOBIO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5161" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5463" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5161" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5162" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5464" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG11 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5162" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5163" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxyisobutyrate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mmsB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyisobutyrate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.31</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5465" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG11 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5163" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5164" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BHBDCLOS__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hbd ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta;-hydroxybutyryl-CoA dehydrogenase subunit ) or ( (S)-3-hydroxybutyryl-CoA dehydrogenase (NAD+) )</html:p>
<html:p>SUBSYSTEM: acetyl-CoA fermentation to butyrate I</html:p>
<html:p>SUBSYSTEM: 3-hydroxypropionate/4-hydroxybutyrate cycle</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TAGAALDOL__45__RXN" name="Tagatose-bisphosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lacD ) or ( kbaY and kbaZ ) or ( gatY and gatZ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA and KbaY ) or ( NA and GatY )</html:p>
<html:p>SUBSYSTEM: galactitol degradation</html:p>
<html:p>SUBSYSTEM: lactose and galactose degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.40</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TAGATOSE__45__1__45__6__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6581" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation III (mycothiol-dependent)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD1G__45__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="CPD1G__45__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__HYDROXYMETHYLMYCOTHIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__99__46__9__45__RXN" name="Methylenetetrahydromethanopterin dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mtd ) or ( mtd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Mtd ) or ( Mtd )</html:p>
<html:p>SUBSYSTEM: methanogenesis from CO2</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.9</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENETETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
      <speciesReference species="__124__Oxidized__45__Factor__45__F420__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHENYLTETRAHYDROMETHANOPTERIN" stoichiometry="1"/>
      <speciesReference species="__124__Reduced__45__Factor__45__F420__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5470" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5168" stoichiometry="1"/>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="CPD__45__5169" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5472" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
      <speciesReference species="CPD__45__5170" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
      <speciesReference species="OLIGOSACCHARIDE__45__DIPHOSPHODOLICHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5471" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
      <speciesReference species="CPD__45__5169" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5170" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NARINGENIN__45__3__45__DIOXYGENASE__45__RXN" name="Naringenin 3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At1g78550 ) or ( AT5g24530 ) or ( AT3g19000 ) or ( TT6 ) or ( AT4g10490 ) or ( AT4g16330 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavanone 3-hydroxylase ) or ( flavanone 3-hydroxylase ) or ( flavanone 3-hydroxylase ) or ( flavanone 3&amp;beta;-hydroxylase ) or ( flavanone 3-hydroxylase ) or ( flavanone 3-hydroxylase )</html:p>
<html:p>SUBSYSTEM: flavonoid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.9</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROKAEMPFEROL__45__CMPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE1EPIM__45__RXN" name="ALDOSE-1-EPIMERASE" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( galM ) or ( galM ) or ( mro )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOSE__45__6__45__PHOSPHATE__45__ISOMERASE__45__RXN" name="Galactose-6-phosphate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lacA and lacB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactose-6-phosphate isomerase lacB subunit and galactose-6-phosphate isomerase lacA subunit )</html:p>
<html:p>SUBSYSTEM: lactose and galactose degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1241" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TAGATOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CALCIDIOL__45__1__45__MONOOXYGENASE__45__RXN" name="Calcidiol 1-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cyp27b1 and Fdxr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 27B1 and NA )</html:p>
<html:p>SUBSYSTEM: 1,25-dihydroxyvitamin D3 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.13</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CALCIDIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CALCITRIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATE__45__5__45__PHOSPHATASE__45__RXN" name="Thymidylate 5&apos;-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yfdR ) or ( yfbR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CPS-53 (KpLE1) prophage; deoxyribonucleoside 5&apos;-monophosphate phosphatase ) or ( dCMP phosphohydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.35</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5482" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MUM4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__L__45__RHAMNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5481" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NRS/ER )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-L-rhamnose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__663" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__L__45__RHAMNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Serine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sgaA ) or ( sgaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine-glyoxylate aminotransferase subunit ) or ( serine-glyoxylate aminotransferase subunit )</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTPSYN__45__RXN" name="CTP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CTPS ) or ( pyrG ) or ( CTPS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CTP synthase 1 ) or ( PyrG ) or ( CTP synthase II )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLORNDEACET__45__RXN" name="Acetylornithine deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( argE ) or ( argE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( ArgE )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.16</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ALPHA__45__ACETYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__GLN__45__RXN" name="NAD(+) synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( nadE ) or ( QNS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NadE ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling (plants)</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__698" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NCED3 ) or ( NCED9 ) or ( NCED6 ) or ( NCED2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: abscisic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.51</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD1F__45__4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7424" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__4" stoichiometry="1"/>
      <speciesReference species="CPD1F__45__92" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__18__45__RXN" name="&amp;beta;-alanine--pyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( &amp;beta;-alanine transaminase )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine degradation II</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.18</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__5__45__RXN" name="Betaine--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gbt ) or (  ) or ( Bhmt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( glycine betaine-homocysteine methyltransferase subunit ) or ( betaine-homocysteine S-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="BETAINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8779" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: 2-keto-L-gulonate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__SORBOSONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9056" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8777" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( kdaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-keto-3-deoxy-D-arabinonate dehydratase subunit )</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DH__45__3__45__DO__45__D__45__ARABINONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__654" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="VAGL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.48</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINOPENTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__280" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8776" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( araDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-arabinose 1-dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.117</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__356" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8775" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( araE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-ketoglutaric semialdehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.26</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__654" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2KETO__45__3METHYLVALERATE__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bfmBAA and bfmBAB and pdhD and bfmBB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-keto-isovalerate dehydrogenase component &amp;alpha; subunit and lipoamide acyltransferase component subunit and dihydrolipoyl dehydrogenase component subunit and 2-keto-isovalerate dehydrogenase component &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4319" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: maackiain conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.170</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3631" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8774" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( araA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.46</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__368" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8773" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xyrA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: xylose degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5441" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 2&apos;-dioxygenase &amp;alpha; subunit and tryptophan 2&apos;-dioxygenase &amp;gamma; subunit and tryptophan 2&apos;-dioxygenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.99.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__GLYCOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5443" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 2&apos;-dioxygenase &amp;alpha; subunit and tryptophan 2&apos;-dioxygenase &amp;gamma; subunit and tryptophan 2&apos;-dioxygenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.99.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__GLYCOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__KETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_25__45__DIOXOVALERATE__45__DEHYDROGENASE__45__RXN" name="2,5-dioxovalerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( dopDH ) or ( araE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-ketoglutaric semialdehyde dehydrogenase subunit ) or ( 2,5-dioxopentanoate dehydrogenase subunit ) or ( &amp;alpha;-ketoglutaric semialdehyde dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation III</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.26</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__654" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMP__45__DEHYDROG__45__RXN" name="IMP dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( IMPDH ) or ( guaB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( IMP dehygrogenase ) or ( GuaB ) or ( NA )</html:p>
<html:p>SUBSYSTEM: urate biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: ureide biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: guanosine nucleotides de novo biosynthesis</html:p>
<html:p>SUBSYSTEM: purine degradation I (aerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of purines degradation in plants</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides II (plant)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.205</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINYLDIAMINOPIMTRANS__45__RXN" name="Succinyldiaminopimelate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( argD ) or ( dapC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ArgD ) or ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.17</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__SUCCINYL__45__2__45__AMINO__45__6__45__KETOPIMELATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__SUCCINYLLL__45__2__45__6__45__DIAMINOPIMELATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8782" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( BAA13144 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-sorbose/L-sorbosone dehydrogenase 64.5 kD subunit and L-sorbose/L-sorbosone dehydrogenase 62.5 kD subunit ) or ( L-sorbose dehydrogenase, FAD dependent )</html:p>
<html:p>SUBSYSTEM: 2-keto-L-gulonate biosynthesis</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.32</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9569" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__SORBOSONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8783" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Rgn ) or ( Rgn )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( regucalcin ) or ( NA )</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis VI</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GULONO__45__1__45__4__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8780" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__SORBOSONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9055" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8781" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( sndH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-sorbosone dehydrogenase 1 )</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9055" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__1__46__99__45__RXN" name="2-methylisocitrate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acnA ) or ( acnB ) or ( acnB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aconitate hydratase 1 ) or ( aconitate hydratase 2 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle I</html:p>
<html:p>SUBSYSTEM: 2-methylcitrate cycle II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.99</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1136" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLNEURAMINATE__45__MONOOXYGENASE__45__RXN" name="CMP-N-acetylneuraminate monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( none )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CMP-N-acetylneuraminate monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYLNEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__273" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3PGAREARR__45__RXN" name="Phosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( gpmA ) or (  ) or (  ) or (  ) or ( TA1347 ) or ( gpmM ) or ( pgm ) or (  ) or ( pgm ) or ( pgm ) or ( ytjC ) or (  ) or ( PGAM-i )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglyceromutase 1 monomer ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( phosphoglycerate mutase, cofactor independent ) or ( NA ) or ( NA ) or ( phosphoglycerate mutase subunit ) or ( phosphoglycerate mutase subunit ) or ( phosphoglycerate mutase 2 ) or ( NA ) or ( phosphoglycerate mutase )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway III (semi-phosphorylative)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: glycolysis IV (plant cytosol)</html:p>
<html:p>SUBSYSTEM: glycolysis II</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8789" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9088" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9089" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8788" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GERANYLGERANYL__45__PP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9066" stoichiometry="1"/>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9088" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENGLYOXRED__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylglyoxylate:acceptor oxidoreductase )</html:p>
<html:p>SUBSYSTEM: phenylacetate degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>PROTEIN_CLASS: 1.2.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: E__45__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="PHENYLGLYOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="E__45__" stoichiometry="2"/>
      <speciesReference species="BENZOYLCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8785" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BchF )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9064" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8784" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__329" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6524" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 3-oxidase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis III (early C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__638" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6203" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8787" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9065" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9066" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6523" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox1 ) or ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 3-oxidase ) or ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__120" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6201" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8786" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchY and bchX and bchZ ) or ( bchZ and bchY and bchX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorophyllide a reductase Y subunit and chlorophyllide a reductase Z subunit and chlorophyllide a reductase X subunit ) or ( chlorophyllide reductase subunit X and chlorophyllide reductase subunit Y and chlorophyllide reductase subunit Z )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9064" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9065" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6522" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox1 ) or ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 3-oxidase ) or ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis II (early C-3 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__97" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__74__45__RXN" name="7-deoxyloganin 7-hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: secologanin and strictosidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.74</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_7__45__DEOXYLOGANIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LOGANIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1863" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fructan degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2281" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
      <speciesReference species="_6G__45__KESTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP__45__GLUCOSIDASE__45__RXN" name="GDP-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( gmm )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.42</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ITACONYL__45__COA__45__HYDRATASE__45__RXN" name="Itaconyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: itaconate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.56</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1137" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__627" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4320" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: maackiain conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.115</html:p>
<html:p>COFACTOR: MALONYL__45__COA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4222" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4223" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLTRANSFER__45__RXN" name="Amino-acid N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( argA ) or ( argJ ) or ( ARG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ArgA ) or ( ArgJ ) or ( acetylglutamate synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: ornithine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: maackiain conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: MALONATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4223" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__4222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4322" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: maackiain conjugates interconversion</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4222" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__3631" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANIDINOACETATE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Guanidinoacetate N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Gamt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glycine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.2</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANIDOACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CREATINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5461" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NRS/ER )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__RHAMNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__REDUCT__45__NADPH__45__RXN" name="Glutathione reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSR ) or ( gor ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione reductase subunit ) or ( glutathione reductase (NADPH) ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ascorbate glutathione cycle</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions II</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8791" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9090" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9067" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8792" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchY and bchX and bchZ ) or ( bchZ and bchY and bchX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorophyllide a reductase Y subunit and chlorophyllide a reductase Z subunit and chlorophyllide a reductase X subunit ) or ( chlorophyllide reductase subunit X and chlorophyllide reductase subunit Y and chlorophyllide reductase subunit Z )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9097" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8793" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BchF )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9097" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9065" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8794" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bchP ) or ( bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9098" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9099" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYHYPUSINE__45__MONOOXYGENASE__45__RXN" name="Deoxyhypusine monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DOHH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hypusine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.29</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9973" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9974" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLTHIOADENOSINE__45__NUCLEOSIDASE__45__RXN" name="Methylthioadenosine nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mtn ) or ( mtn ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MTA/SAH nucleosidase ) or ( MTA/SAH nucleosidase ) or ( MTA nucleosidase subunit )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.16</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADENINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__560" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8790" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: bacteriochlorophyll a biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9089" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9090" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8798" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_13__45__HYDROXY__45__MAGNESIUM__45__PROTOPORP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_131__45__OXO__45__MAGNESIUM__45__PROTOPORPHYRIN__45__IX__45__13__45__M" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8797" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MG__45__PROTOPORPHYRIN__45__MONOMETHYL__45__ESTER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_13__45__HYDROXY__45__MAGNESIUM__45__PROTOPORP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CPD__45__558_TO_CO__45__A_COF_RXN" name="CPD-558_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CPD__45__558" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8796" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bchP ) or ( bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9100" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9096" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8795" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bchP ) or ( bchP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl reductase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9099" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9100" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45____45__PYRUVATE__45__AMINOTRANSFERASE__45__RXN" name="Serine--pyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Agxt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine-pyruvate aminotransferase, mitochondrial subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.51</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8799" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bchE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of bacteriochlorophyll a biosynthesis</html:p>
<html:p>SUBSYSTEM: chlorophyllide a biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_131__45__OXO__45__MAGNESIUM__45__PROTOPORPHYRIN__45__IX__45__13__45__M" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIVINYL__45__PROTOCHLOROPHYLLIDE__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5423" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 2&apos;-dioxygenase &amp;alpha; subunit and tryptophan 2&apos;-dioxygenase &amp;gamma; subunit and tryptophan 2&apos;-dioxygenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.99.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__341" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5422" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 2&apos;-dioxygenase &amp;alpha; subunit and tryptophan 2&apos;-dioxygenase &amp;gamma; subunit and tryptophan 2&apos;-dioxygenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.99.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__INDOLYLGLYCOLALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5421" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 2&apos;-dioxygenase &amp;alpha; subunit and tryptophan 2&apos;-dioxygenase &amp;gamma; subunit and tryptophan 2&apos;-dioxygenase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation V (side chain pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.13.99.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE__45__3__45__GLYCOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R161__45__RXN" name="Nicotine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ndhC and ndhB and ndhA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NdhA and NdhB and NdhC )</html:p>
<html:p>SUBSYSTEM: nicotine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.4</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__6__45__HYDROXYNICOTINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__SYNTHASE__45__RXN" name="Cystathionine &amp;beta;-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Cbs ) or ( CYS4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine &amp;beta;-synthase subunit ) or ( Cys4 )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae)</html:p>
<html:p>SUBSYSTEM: homocysteine and cysteine interconversion</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis/homocysteine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__151__45__RXN" name="Inositol-polyphosphate multikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( IPK2&amp;alpha; ) or ( IPK2&amp;beta; )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Inositol polyphosphate multikinase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of lipid-dependent phytate biosynthesis</html:p>
<html:p>SUBSYSTEM: lipid-dependent phytate biosynthesis I (via Ins(1,4,5)P3)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.151</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP735A2 ) or ( CYP735A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trans-zeatin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4205" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4206" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6547" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6225" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6226" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6546" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__86" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6225" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6545" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-1 ) or ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__138" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6227" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1884" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT4G33670 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-galactose dehydrogenase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis I (L-galactose pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__330" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6544" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis II (early C-3 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__95" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6228" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP735A2 ) or ( CYP735A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trans-zeatin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4201" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6543" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__84" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6223" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPT4 ) or ( IPT7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trans-zeatin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4203" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6542" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6221" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6222" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4306" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP735A2 ) or ( CYP735A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trans-zeatin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4203" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4204" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6541" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis I (non C-3, non C-13 hydroxylation)</html:p>
<html:p>SUBSYSTEM: superpathway of gibberellin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__84" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6221" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4307" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPT1 ) or ( IPT5 ) or ( IPT3 ) or ( IPT7 ) or ( IPT8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: trans-zeatin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.27</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4205" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADH__45__KINASE__45__RXN" name="NADH kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NADK1 ) or ( NADK3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADK1 subunit ) or ( NADK3 subunit )</html:p>
<html:p>SUBSYSTEM: NAD/NADH phosphorylation and dephosphorylation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.86</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4301" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( treX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isoamylase )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.68</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IPT4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: trans-zeatin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4201" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1882" name="GDP-mannose 3,5-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GME ) or ( GME )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( GDP-D-mannose-3,5-epimerase )</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis IV (extended VTC2 cycle)</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis III (VTC2 cycle)</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis I (L-galactose pathway)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__L__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6549" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P450-1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gibberellin biosynthesis IV (Gibberella fujikuroi)</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6227" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6228" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tktA ) or ( tktA ) or ( tktA ) or ( tktB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( TktA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (partial)</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation II (RuMP Cycle)</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>SUBSYSTEM: Rubisco shunt</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdxK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PdxK )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>SUBSYSTEM: superpathway of pyridoxal 5&apos;-phosphate biosynthesis and salvage</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIGLUCOACETYL__45__DOCOSANOATE__45__HYDROLYSIS__45__RXN" name="acetic-ester acetylhydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: sophorosyloxydocosanoate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIGLUCOACETYL__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="DIGLUCO__45__DOCOSANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRROLINEDEH__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6550" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GA2ox1 ) or ( GA2ox3 ) or ( GA2ox1 ) or ( GA2ox2 ) or ( GA2ox1 ) or ( GA3ox1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( gibberellin 2&amp;beta;,3&amp;beta;-hydroxylase )</html:p>
<html:p>SUBSYSTEM: gibberellin inactivation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.-</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__137" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6224" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPPHOSPHAT__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NAD/NADH phosphorylation and dephosphorylation</html:p>
<html:p>SUBSYSTEM: NAD phosphorylation and dephosphorylation</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__681" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ddc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-2,4-diaminobutyrate decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: rhizobactin 1021 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__470" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GALE ) or (  ) or ( galE ) or ( galE ) or ( UGE3 ) or ( galE ) or ( UGE4 ) or ( UGE2 ) or ( UGE1 ) or ( galE ) or ( UGE5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-galactose 4-epimerase ) or ( UDP-galactose 4-epimerase ) or ( UDP-glucose 4-epimerase monomer ) or ( NA ) or ( UDP-D-glucose/UDP-D-galactose 4-epimerase subunit ) or ( NA ) or ( UDP-G-glucose/UDP-D-galactose 4-epimerase subunit ) or ( UDP-D-glucose/UDP-D/galactose 4-epimerase subunit ) or ( UDP-D-glucose/UDP-D-galactose 4-epimerase subunit ) or ( UDP-galactose 4-epimerase subunit ) or ( UDP-D-glucose/UDP-D-galactose 4-epimerase subunit )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__3__46__9__45__RXN" name="Butyrate-acetoacetate CoA-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ctfB and ctfA ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( butyrate-acetoacetate CoA-transferase, subunit A and butyrate-acetoacetate CoA-transferase, subunit B ) or ( NA ) or ( butyryl-CoA:acetoacetate CoA-transferase &amp;alpha; subunit and butyryl-CoA:acetoacetate CoA-transferase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="BUTYRIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__64__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Coq3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (prokaryotic)</html:p>
<html:p>SUBSYSTEM: ubiquinone-9 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.64</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9957" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LTAA__45__RXN" name="L-allo-threonine aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GLY1 ) or ( ltaE ) or ( glyA ) or ( ltaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-threonine aldolase subunit ) or ( LtaA ) or ( GlyA ) or ( L-allo-threonine aldolase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ALLO__45__THREONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKAPHOSPHA__45__RXN" name="Alkaline phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( phoA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PhoA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOBUTFORMLY__45__RXN" name="formate C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pflB ) or ( tdcE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PflB ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: threonine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONOLACT__45__RXN" name="6-phosphogluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pgl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: formaldehyde oxidation I</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.31</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMET__45__RXN" name="5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( metE ) or ( metE ) or ( metE ) or ( AtMS3 ) or ( AtMS1 ) or ( AtMS2 ) or ( met6 ) or ( StMS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( methionine synthase ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (by sulfhydrylation)</html:p>
<html:p>SUBSYSTEM: superpathway of methionine biosynthesis (transsulfuration)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.14</html:p>
<html:p>SIDE: CPD__45__1301</html:p>
<html:p>SIDE: CPD__45__1302</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1302" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1301" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2103" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polygalacturonase and polygalacturonase &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: homogalacturonan degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.15</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__galacturonosyl__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__galacturonosyl__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AtPME3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pectin methylesterase ) or ( pectin methylesterase )</html:p>
<html:p>SUBSYSTEM: homogalacturonan degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Methylesterified__45__homogalacturonan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METOH" stoichiometry="1"/>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__galacturonosyl__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R201__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xenB ) or ( xenA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: nitroglycerin degradation</html:p>
<html:p>PROTEIN_CLASS: 1.7.3.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__143" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="CPD__45__145" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8743" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mpd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methyl parathion degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8973" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
      <speciesReference species="CPD__45__8974" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8740" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pnpC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrophenol degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROQUINONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXYMUCONIC__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8741" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nphA2 and nphA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-nitrophenol hydroxylase component B and 4-nitrophenol hydroxylase component A )</html:p>
<html:p>SUBSYSTEM: 4-nitrophenol degradation II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NITRITE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__158" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8130" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8746" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( opd )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( organophosphate acid anhydrase )</html:p>
<html:p>SUBSYSTEM: paraoxon degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARAOXON" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
      <speciesReference species="DIETHYLPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__OXOPENT__45__4__45__ENOATE__45__HYDRATASE__45__RXN" name="2-oxopent-4-enoate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xylJ ) or ( mhpD ) or (  ) or ( cmtF ) or ( todG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-oxopent-4-enoate hydratase subunit ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 2-oxopentenoate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of aerobic toluene degradation</html:p>
<html:p>SUBSYSTEM: toluene degradation II (aerobic) (via 4-methylcatechol)</html:p>
<html:p>SUBSYSTEM: toluene degradation V (aerobic) (via toluene-cis-diol)</html:p>
<html:p>SUBSYSTEM: toluene degradation IV (aerobic) (via catechol)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation IX</html:p>
<html:p>SUBSYSTEM: p-cymene degradation</html:p>
<html:p>SUBSYSTEM: catechol degradation I (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: catechol degradation II (meta-cleavage pathway)</html:p>
<html:p>SUBSYSTEM: toluene degradation I (aerobic) (via o-cresol)</html:p>
<html:p>SUBSYSTEM: p-cumate degradation</html:p>
<html:p>SUBSYSTEM: meta cleavage pathway of aromatic compounds</html:p>
<html:p>SUBSYSTEM: 3-phenylpropionate and 3-(3-hydroxyphenyl)propionate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.80</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXOPENTENOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXY__45__2__45__KETOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8747" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pdeA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphodiesterase subunit )</html:p>
<html:p>SUBSYSTEM: diethylphosphate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ETOH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIETHYLPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__8978" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase )</html:p>
<html:p>SUBSYSTEM: ADP-L-glycero-&amp;beta;-D-manno-heptose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALPHABETA__45__D__45__HEPTOSE__45__7__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__BETA__45__D__45__HEPTOSE__45__17__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4342" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase )</html:p>
<html:p>SUBSYSTEM: ADP-L-glycero-&amp;beta;-D-manno-heptose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="D__45__BETA__45__D__45__HEPTOSE__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP__45__D__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4361" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gmhB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D,D-heptose 1,7-bisphosphate phosphatase )</html:p>
<html:p>SUBSYSTEM: ADP-L-glycero-&amp;beta;-D-manno-heptose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__BETA__45__D__45__HEPTOSE__45__17__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__BETA__45__D__45__HEPTOSE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__178__45__RXN" name="3-hydroxy-2-methylbutyryl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( fadB2x ) or ( HADH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-2-methylbutyryl-CoA dehydrogenase subunit ) or ( 3-hydroxy-2-methylbutyryl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: 2-methylbutyrate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.178</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__ACETO__45__ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16BDEPHOS__45__RXN" name="Fructose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( glpX ) or ( ybhA ) or ( fbp ) or ( fbp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( Fbp ) or ( fructose-1,6-bisphosphatase monomer )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation III (dihydroxyacetone cycle)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__CARBAMOYLPUTRESCINE__45__AMIDASE__45__RXN" name="N-carbamoylputrescine amidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( aguB ) or ( At2g27450 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-carbamoylputrascine amidohydrolase subunit ) or ( At2g27450-monomer )</html:p>
<html:p>SUBSYSTEM: arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.53</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__597" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN490__45__3608" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BGluT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD490__45__7" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__4__46__22__45__RXN" name="1-pyrroline-4-hydroxy-2-carboxylate deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.22</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1128" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__654" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__248__45__RXN" name="Salutaridine reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( salutaridine oxidoreductase )</html:p>
<html:p>SUBSYSTEM: morphine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.248</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SALUTARIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SALUTARIDINOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__3__45__MONOOXYGENASE__45__RXN" name="Tyrosine 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( TH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( tyrosine hydroxylase subunit )</html:p>
<html:p>SUBSYSTEM: rosmarinic acid biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betalain biosynthesis (to betalamic acid)</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>SUBSYSTEM: Superpathway of rosmarinic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.2</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__5881</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DARABKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fucK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-fuculokinase )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: D-arabinose degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__RIBULOSE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8739" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pnpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-nitrophenol degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRITE" stoichiometry="1"/>
      <speciesReference species="P__45__BENZOQUINONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R102__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ectA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ectoine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__470" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__L__45__24__45__DIAMINOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTTRANSAM__45__RXN" name="Histidine aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: imidazole-lactate degradation</html:p>
<html:p>SUBSYSTEM: histidine degradation IV</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.38</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTEPADENYLYLTRAN__45__RXN" name="Pantetheine-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AtCoaD ) or ( coaD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( pantetheine-phosphate adenylyltransferase monomer )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis III</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzymeA biosynthesis II</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis I</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.3</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__SULFATASE__45__RXN" name="Choline-sulfatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( betC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: choline-O-sulfate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.6</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: SULFATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__543" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8735" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: podophyllotoxin and 6-methoxypodophyllotoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8958" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8960" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8736" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: podophyllotoxin and 6-methoxypodophyllotoxin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8960" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8772" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pentose and pentitol degradation</html:p>
<html:p>SUBSYSTEM: L-arabinose degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARABINOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARABITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8771" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( bluB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: 5,6-dimethylbenzimidazole biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ERYTHROSE__45__4P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FMNH2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYLBENZIMIDAZOLE" stoichiometry="2"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8770" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CobC )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYLCOBALAMIN__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRIC__45__OXIDE__45__SYNTHASE__45__RXN" name="Nitric-oxide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NOS2C ) or ( NOS2B ) or ( NOS2A ) or ( NOS1 ) or ( NOS3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NOS2C monomer ) or ( NOS2B monomer ) or ( NOS2A monomer ) or ( NOS1 monomer ) or ( NOS3 monomer )</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.39</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NITRIC__45__OXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRIC__45__OXIDE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SEDOBISALDOL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( fbaA ) or ( fbaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-1,6-bisphosphate aldolase subunit ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: oxygenic photosynthesis</html:p>
<html:p>SUBSYSTEM: Calvin-Benson-Bassham cycle</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.-</html:p>
<html:p>SIDE: ERYTHROSE__45__4P</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__1__45__7__45__P2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTACETYLTRAN__45__RXN" name="Maltose O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( maa )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Maa )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.79</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLMALTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__4__45__RXN" name="Formiminotetrahydrofolate cyclodeaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( FTCD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( formimidoyltransferase-cyclodeaminase subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__671" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCROSE__45__SYNTHASE__45__RXN" name="Sucrose synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SS ) or (  ) or ( SUS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sucrose synthase ) or ( sucrose synthase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.13</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCROSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINAMID__45__RXN" name="Nicotinamidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pncA ) or ( PNC1 and PNC1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: pyridine nucleotide cycling (plants)</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.19</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__68__45__RXN" name="2-deoxyglucose-6-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yniC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-deoxyglucose-6-phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.68</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEOXY__45__D__45__GLUCOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__DEOXY__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIISOPROPYL__45__FLUOROPHOSPHATASE__45__RXN" name="Diisopropyl-fluorophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( opaA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Organophosphorus acid anhydrolase-2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIISOPROPYL__45__FLUOROPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="F__45__" stoichiometry="1"/>
      <speciesReference species="DIISOPROPYL__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__4__46__1__46__14__45__RXN" name="1-aminocyclopropane-1-carboxylate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACS4 ) or ( ACS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-aminocyclopropane-1-carboxylate synthase ) or ( 1-aminocyclopropane-1-carboxylate synthase )</html:p>
<html:p>SUBSYSTEM: ethylene biosynthesis from methionine</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.14</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: _5__45__METHYLTHIOADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__68" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3SC23OSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: orthanilate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8218" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8720" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__168__45__RXN" name="2-dehydropantolactone reductase (A-specific)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: pantothenate and coenzyme A biosynthesis III</html:p>
<html:p>SUBSYSTEM: pantothenate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.168</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__DEHYDROPANTOYL__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOYL__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLENE__45__OXIDE__45__CYCLASE__45__RXN" name="Allene-oxide cyclase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AOC2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( allene oxide cyclase )</html:p>
<html:p>SUBSYSTEM: superpathway of lipoxygenase</html:p>
<html:p>SUBSYSTEM: jasmonic acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__728" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__729" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEHYDRO__45__L__45__GULONATE__45__DECARBOXYLASE__45__RXN" name="Dehydro-L-gulonate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: glucuronate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.34</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETO__45__L__45__GULONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAMMA__45__GLUTAMYLCYCLOTRANSFERASE__45__RXN" name="&amp;gamma;-glutamylcyclotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: L__45__2__45__AMINO__45__ACID</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__2__45__AMINO__45__ACID" stoichiometry="1"/>
      <speciesReference species="_5__45__OXOPROLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8768" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9045" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9049" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8769" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiA ) or ( cobB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( CobB )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9049" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__689" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5001" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yicI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-xylosidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8527" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8766" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9044" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9048" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R526__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mcrB and mcrA and mcrG ) or ( acsD and acsC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta; subunit and &amp;alpha; subunit and &amp;gamma; subunit ) or ( corrinoid/iron-sulfur protein &amp;alpha; subunit and corrinoid/iron-sulfur protein &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: carbon tetrachloride degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__843" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__681" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8767" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9048" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9045" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8764" name="Precorrin-6Y C5,15-methyltransferase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9047" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9043" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8765" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9043" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9044" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8762" name="Precorrin-4 C11-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.133</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9042" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8763" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ACETALD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9042" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9047" stoichiometry="1"/>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8761" name="Precorrin-3B C17-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.131</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9040" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9041" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8760" name="Cobalt-factor II C(20)-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cobalt-precorrin-2 C(20)-methyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.151</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9039" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9040" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPAMIDOTRANS__45__RXN" name="Amidophosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ade4 ) or ( purF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( PurF )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis II</html:p>
<html:p>SUBSYSTEM: 5-aminoimidazole ribonucleotide biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.14</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LINABSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-hexachlorocyclohexane degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: HCL</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__15" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_124__45__TCB" stoichiometry="1"/>
      <speciesReference species="HCL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRDAMPTRANS__45__RXN" name="Pyridoxamine-phosphate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( colD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-4-keto-6-deoxy-D-mannose-3-dehydrase subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.54</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLT" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__12__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PTS ) or ( sscR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-pyruvoyl tetrahydrobiopterin synthase monomer ) or ( 6-pyruvoyl tetrahydropterin synthase )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.12</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3284" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIDH ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via daidzein)</html:p>
<html:p>SUBSYSTEM: pterocarpan biosynthesis</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of pterocarpan biosynthesis (via formononetin)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.105</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXYISOFLAVANONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DAIDZEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8759" name="Sirohydrochlorin cobaltochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbiK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sirohydrochlorin cobaltochelatase subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
      <speciesReference species="CO__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9039" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8755" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine hydroxylase &amp;alpha; subunit and purine hydroxylase &amp;beta; subunit and purine hydroxylase &amp;gamma; subunit and purine hydroxylase &amp;delta; subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8751" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8752" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8753" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9017" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R13__45__RXN" name="Aminoimidazolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__54" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__60" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QOR__45__RXN" name="NADPH:quinone reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( qor )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Qor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Semiquinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8754" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9017" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THTOREDUCT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRAHYDROTHIOPHENE__45__1__45__OXIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRAHYDROTHIOPHENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3283" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IFS-Tp ) or ( IFS1 ) or ( CYP Ge-8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isoflavone synthase ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3061" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXYISOFLAVANONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R266__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( badK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BadK )</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__533" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__537" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5074" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yjjX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ITPase/XTPase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_PALMITYL__45__COA_COF_RXN" name="CO-A_TO_PALMITYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMITYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4301" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( lpcA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-sedoheptulose 7-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: ADP-L-glycero-&amp;beta;-D-manno-heptose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__ALPHABETA__45__D__45__HEPTOSE__45__7__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOPAMINE__45__BETA__45__MONOOXYGENASE__45__RXN" name="Dopamine-&amp;beta;-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DBH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dopamine &amp;beta;-monooxygenase subunit )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.17.1</html:p>
<html:p>SIDE: L__45__DEHYDRO__45__ASCORBATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ASCORBATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NOREPINEPHRINE" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__NH3__45__RXN" name="NAD(+) synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nadE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NadE )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 6.3.1.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8702" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP80A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: bisbenzylisoquinoline alkaloid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__N__45__METHYLCOCLAURINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8925" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8701" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 7OMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (R,S)-reticuline 7-O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: laudanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="R__45__RETICULINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8924" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8700" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( 7OMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (R,S)-reticuline 7-O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: laudanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__RETICULINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8924" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8707" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid serotonin amides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: HYDROGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SEROTONIN" stoichiometry="1"/>
      <speciesReference species="HYDROGEN__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8709" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CASHT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid serotonin amides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: CAFFEOYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: CAFFEOYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SEROTONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8934" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENTF__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( entF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SERYL__45__AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOYL__45__COA__45__DEHYDRATASE__45__RXN" name="Lactoyl-CoA dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta; subunit and &amp;alpha; subunit )</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate II (acrylate pathway)</html:p>
<html:p>SUBSYSTEM: L-alanine fermentation to propionate and acetate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.54</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__LACTOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACRYLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5063" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( miaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopentenyl-adenosine A37 tRNA methylthiolase MiaB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__6__45__ISOPENTYL__45__ADENOSINE__45__37__45__TRNA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYLTHIO__45__N__45__6__45__ISOPENTYL__45__ADENOSINE__45__37__45__" stoichiometry="1"/>
      <speciesReference species="CH33ADO" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5065" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( paaI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__782" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__1__46__17__45__RXN" name="Isopenicillin-N epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cefD ) or ( cefD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of penicillin, cephalosporin and cephamycin biosynthesis</html:p>
<html:p>SUBSYSTEM: deacetylcephalosporin C biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOPENICILLIN__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PENICILLIN__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5061" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-heptose:LPS heptosyltransferase II )</html:p>
<html:p>SUBSYSTEM: superpathway of lipopolysaccharide biosynthesis</html:p>
<html:p>SUBSYSTEM: Lipid A-core biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__929" stoichiometry="1"/>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="CPD0__45__930" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5057" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rfaC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-heptose:LPS heptosyl transferase I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__L__45__GLYCERO__45__D__45__MANNO__45__HEPTOSE" stoichiometry="1"/>
      <speciesReference species="KDO2__45__LIPID__45__IVA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
      <speciesReference species="HEPTOSYL__45__KDO2__45__LIPID__45__IVA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCOSEPP__45__RXN" name="Glucose-1-phosphate thymidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rfbA ) or ( rffH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( dTDP-glucose pyrophosphorylase 2 )</html:p>
<html:p>SUBSYSTEM: dTDP-L-rhamnose biosynthesis I</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>SUBSYSTEM: O-antigen biosynthesis (E. coli)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.24</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGOMYELIN__45__PHOSPHODIESTERASE__45__RXN" name="Sphingomyelin phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Smpd4 ) or ( Enpp7 ) or ( Smpd2 ) or ( Smpd3 ) or ( Smpd1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingomyelin phosphodiesterase 4 ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 7 ) or ( sphingomyelin phosphodiesterase 2, neutral ) or ( sphingomyelin phosphodiesterase 3, neutral ) or ( sphingomyelin phosphodiesterase 1, acid lysosomal )</html:p>
<html:p>SUBSYSTEM: sphingomyelin metabolism</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.12</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PHOSPHORYL__45__CHOLINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sphingomyelins__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ceramides__124__" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARDIOLIPSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cls ) or ( ybhO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( cardiolipin synthase 2 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.-</html:p>
<html:p>SIDE: GLYCEROL</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARDIOLIPIN" stoichiometry="1"/>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__19__45__RXN" name="Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( bedD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cis-benzene glycol dehydrogenase subunit ) or ( cis-benzene glycol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: benzene degradation</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.19</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__288" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2301" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( aidB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AidB )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R607__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dbfB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dibenzofuran degradation</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__927" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__928" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8725" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: gallotannin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: _1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8953" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__8956" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8724" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: gallotannin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: _1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8953" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8955" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R267__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( badH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BadH )</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__537" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__554" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__RHAMNONATE__45__DEHYDRATASE__45__RXN" name="L-rhamnonate dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( yfaW )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-rhamnonate dehydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.90</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__RHAMNONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDRO__45__3__45__DEOXY__45__L__45__RHAMNONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8722" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galloyltransferase C subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: gallotannin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: _1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="_12346__45__PENTAKIS__45__O__45__GALLOYL__45__BETA__45__D__45__GLUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__8954" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: gallotannin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: _1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="_12346__45__PENTAKIS__45__O__45__GALLOYL__45__BETA__45__D__45__GLUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8952" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8720" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tellimagrandin II O2 oxidoreductase subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: cornusiin E biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8949" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8950" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HADTHAUERA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( had )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: anaerobic aromatic compound degradation (Thauera aromatica)</html:p>
<html:p>SUBSYSTEM: benzoyl-CoA degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__HYDROXYCYCLOHEX__45__1__45__ENE__45__1__45__CARBONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__OXOCYCLOHEX__45__1__45__ENE__45__1__45__CARBONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8727" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: gallotannin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: _1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8952" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CPD__45__8956" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8726" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: gallotannin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>SIDE: _1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8954" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8957" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2121" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AT1G72970 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;omega;-hydroxyacid dehydrogenase ) or ( NA )</html:p>
<html:p>SUBSYSTEM: suberin biosynthesis</html:p>
<html:p>SUBSYSTEM: cutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_18__45__HYDROXYOLEATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_18__45__OXOOLEATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__29__45__RXN" name="2-(acetamidomethylene)succinate hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: vitamin B6 degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.29</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__565" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5040" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( abgB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative p-aminobenzoyl-glutmate hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__AMINO__45__BENZOATE" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__889" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8712" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CASHT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid serotonin amides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CINNAMOYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SEROTONIN" stoichiometry="1"/>
      <speciesReference species="CINNAMOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__8937" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8711" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CASHT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid serotonin amides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: P__45__COUMAROYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SEROTONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8936" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8714" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( THT ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyramine hydroxycinnamoyltransferase ) or ( tyramine N-hydroxycinnamoyltransferase ) or ( NA ) or ( tyramine N-hydroxycinnamoyltransferase )</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid tyramine amides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.110</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SINAPOYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYRAMINE" stoichiometry="1"/>
      <speciesReference species="SINAPOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__8942" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8713" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( THT ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyramine hydroxycinnamoyltransferase ) or ( tyramine N-hydroxycinnamoyltransferase ) or ( NA ) or ( tyramine N-hydroxycinnamoyltransferase )</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid tyramine amides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.110</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CINNAMOYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYRAMINE" stoichiometry="1"/>
      <speciesReference species="CINNAMOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8941" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5038" name="3&apos;,5&apos;-cyclic-AMP phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( cpdA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cAMP phosphodiesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.53</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ANTHRANILATE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Anthranilate N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ANMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: acridone alkaloid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.111</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__402" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8710" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CASHT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid serotonin amides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: FERULOYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FERULOYL__45__COA" stoichiometry="1"/>
      <speciesReference species="SEROTONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__8935" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINLYA__45__RXN" name="Argininosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG4 ) or ( ASL ) or ( argH ) or ( argH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase ) or ( argininosuccinate lyase subunit ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis II (acetyl cycle)</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8719" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: cornusiin E biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_12346__45__PENTAKIS__45__O__45__GALLOYL__45__BETA__45__D__45__GLUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8949" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R545__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-oxo-&amp;Delta;3-4,5,5-trimethylcyclopentenyl acetyl coA synthetase )</html:p>
<html:p>SUBSYSTEM: D-camphor degradation</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.-</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__866" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__867" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8716" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: pentagalloylglucose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="_1__45__O6__45__O__45__DIGALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8947" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8715" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or ( THT ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyramine hydroxycinnamoyltransferase ) or ( tyramine N-hydroxycinnamoyltransferase ) or ( NA ) or ( tyramine N-hydroxycinnamoyltransferase )</html:p>
<html:p>SUBSYSTEM: hydroxycinnamic acid tyramine amides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.110</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: P__45__COUMAROYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYRAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8943" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8718" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: pentagalloylglucose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: CPD__45__8948</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O6__45__O__45__DIGALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8948" stoichiometry="1"/>
      <speciesReference species="CPD__45__8947" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYPROLINE__45__EPIMERASE__45__RXN" name="4-hydroxyproline epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyproline 2-epimerase subunit )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation II</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__HYDROXY__45__L__45__PROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__4__45__HYDROXY__45__D__45__PROLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8717" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hydrolyzable tannin biosynthesis</html:p>
<html:p>SUBSYSTEM: pentagalloylglucose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.-</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8947" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="_1236__45__TETRAKIS__45__O__45__GALLOYL__45__BETA__45__D__45__GLUCOS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPRHAMSYNTHMULTI__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( rfbD and rfbC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA and NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__RHAMNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__709" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis II</html:p>
<html:p>SUBSYSTEM: brassinosteroid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__707" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__708" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__708" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;24 reductase )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.-.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4141" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__707" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2189" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: carbon disulfide oxidation I (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__844" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="CARBONYL__45__SULFIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__707" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DWF5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__700" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__706" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__706" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( STE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;7-sterol-C5-desaturase )</html:p>
<html:p>SUBSYSTEM: plant sterol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPISTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__700" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7699" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( D-3-hydroxyacyl-CoA hydro-lyase )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>SUBSYSTEM: very long chain fatty acid biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_7__45__DEHYDROCHOLESTEROL__45__REDUCTASE__45__RXN" name="7-dehydrocholesterol reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9009" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fomC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fosfomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__551" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9466" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Deoxy__45__Ribonucleoside__45__Monophosphates__124___TO___124__Deoxy__45__Ribonucleosides__124___COF_RXN" name="|Deoxy-Ribonucleoside-Monophosphates|_TO_|Deoxy-Ribonucleosides|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxy__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Deoxy__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9010" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fom3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: fosfomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CPD__45__1829</html:p>
<html:p>SIDE: CPD__45__9037</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9466" stoichiometry="1"/>
      <speciesReference species="CPD__45__9037" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9465" stoichiometry="1"/>
      <speciesReference species="CPD__45__1829" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9013" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT74M1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triterpene sapogenin carboxylic acid glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9474" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9475" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__7__45__RXN" name="Saccharopine dehydrogenase (NAD+, L-lysine forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LYS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: lysine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.7</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9014" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT74M1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triterpene sapogenin carboxylic acid glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9476" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9477" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9011" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( fom4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (S)-2-hydroxypropylphosphonic acid epoxidase subunit )</html:p>
<html:p>SUBSYSTEM: fosfomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9465" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1113" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9012" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT74M1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triterpene sapogenin carboxylic acid glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9470" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9472" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMPSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( ade13 ) or ( purB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( Ade13 ) or ( NA )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine nucleosides I</html:p>
<html:p>SUBSYSTEM: adenosine nucleotides de novo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNONOXIDOREDUCT__45__RXN" name="Fructuronate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( uxuB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of hexuronide and hexuronate degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-D-glucuronide and D-glucuronate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.57</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__MANNONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N6__45__HYDROXYLYSINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="N6-hydroxylysine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( iucB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N6-hydroxylysine O-acetyltransferase subunit )</html:p>
<html:p>SUBSYSTEM: aerobactin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.102</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__265" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__LACTATE__45__DEHYDROGENASE__45__RXN" name="L-lactate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ldh ) or ( ldh2 ) or ( ldh ) or (  ) or ( Ldha ) or ( ldh ) or ( ldh )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( L-lactate dehydrogenase subunit ) or ( L-lactate dehydrogenase subunit ) or ( NA ) or ( lactate dehydrogenase subunit ) or ( Ldh ) or ( L-lactate dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: homolactic fermentation</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to acetate and lactate I</html:p>
<html:p>SUBSYSTEM: hexitol fermentation to lactate, formate, ethanol and acetate</html:p>
<html:p>SUBSYSTEM: Bifidobacterium shunt</html:p>
<html:p>SUBSYSTEM: heterolactic fermentation</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to lactate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.27</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__2__45__DEHYDROGENASE__45__RXN" name="Myo-inositol 2-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myo-inositol 2-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: myo-inositol degradation</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.18</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__365" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3221" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or ( LjCHI2 ) or (  ) or ( LjCHI3 ) or ( LjCHI1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( chalcone isomerase )</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3061" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9015" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SMOX ) or ( FMS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( polyamine oxidase 1 ) or ( polyamine oxidase subunit )</html:p>
<html:p>SUBSYSTEM: spermine and spermidine degradation</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.-</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7687" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AY230247 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavone synthase I )</html:p>
<html:p>SUBSYSTEM: luteolin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.22</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6994" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5734__45__TETRAHYDROXYFLAVONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7686" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AY230247 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavone synthase I )</html:p>
<html:p>SUBSYSTEM: superpathway of isoflavonoids (via naringenin)</html:p>
<html:p>SUBSYSTEM: isoflavonoid biosynthesis II</html:p>
<html:p>SUBSYSTEM: luteolin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.22</html:p>
<html:p>COFACTOR: WATER</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NARINGENIN__45__CMPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__431" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7693" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH5 ) or ( SFA1 ) or ( ADH1 ) or ( ADH4 ) or ( ADH3 ) or ( ADH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase V subunit ) or ( S-(hydroxymethyl)glutathione dehydrogenase subunit ) or ( alcohol dehydrogenase I subunit ) or ( alcohol dehydrogenase IV subunit ) or ( alcohol dehydrogenase III subunit ) or ( alcohol dehydrogenase II subunit )</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7031" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7032" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7694" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH5 ) or ( SFA1 ) or ( ADH1 ) or ( ADH4 ) or ( ADH3 ) or ( ADH2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase V subunit ) or ( S-(hydroxymethyl)glutathione dehydrogenase subunit ) or ( alcohol dehydrogenase I subunit ) or ( alcohol dehydrogenase IV subunit ) or ( alcohol dehydrogenase III subunit ) or ( alcohol dehydrogenase II subunit )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLBUT__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7033" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9020" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( POMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phloroglucinol O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: 1,3,5-trimethoxybenzene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__16" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9494" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7692" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( THI3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( keto-isocaproate decarboxylase subunit )</html:p>
<html:p>SUBSYSTEM: leucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7031" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9021" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RcOMT3 ) or ( OMT1 ) or ( OMT2 ) or ( RcOMT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 1,3,5-trimethoxybenzene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9494" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9499" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9022" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RcOMT3 ) or ( OMT1 ) or ( OMT2 ) or ( RcOMT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 1,3,5-trimethoxybenzene biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9499" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9500" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9023" name="disproportionating enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GDB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen debranching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Truncated__45__Limit__45__Dextrins__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9024" name="Glucan 1,4-&amp;alpha;-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SGA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucoamylase subunit )</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9025" name="maltodextrin phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase subunit )</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOGLUCMUT__45__RXN" name="Phosphoglucomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( pgm II ) or ( pgm ) or ( PGM2 ) or ( pgmA ) or ( pgcA ) or ( PGM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( StpPGM ) or ( NA ) or ( phosphoglucomutase-2 ) or ( NA ) or ( NA ) or ( phosphoglucomutase-1 )</html:p>
<html:p>SUBSYSTEM: starch degradation</html:p>
<html:p>SUBSYSTEM: streptomycin biosynthesis</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: starch biosynthesis</html:p>
<html:p>SUBSYSTEM: sucrose degradation IV</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>SUBSYSTEM: sucrose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__7" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catechol O-methyltransferase, membrane-bound form )</html:p>
<html:p>SUBSYSTEM: superpathway of betalain biosynthesis</html:p>
<html:p>SUBSYSTEM: betaxanthin biosynthesis</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.6</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9819" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( nahAa and nahAb and nahAd and nahAc )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha; subunit of naphthalene 1,2-dioxygenase terminal oxygenase and naphthalene 1,2-dioxygenase terminal oxygenase &amp;beta; subunit and naphthalene 1,2-dioxygenase component A and naphthalene 1,2-dioxygenase component C )</html:p>
<html:p>SUBSYSTEM: indican biosynthesis</html:p>
<html:p>SUBSYSTEM: indigo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE" stoichiometry="1"/>
      <speciesReference species="NADH" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10523" stoichiometry="1"/>
      <speciesReference species="NADH" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9818" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: indican biosynthesis</html:p>
<html:p>SUBSYSTEM: indigo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10523" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOXYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9817" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methylquercetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10520" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10529" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SULT1A3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monoamine-sulfating phenol sulfotransferase )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.1</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PAP</html:p>
<html:p>SIDE: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CAIE__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( caiE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE__45__PRE__45__COFACTOR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARNITINE__45__COFACTOR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9815" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: methylquercetin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10527" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10520" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__1380" name="dihydrospingosine C-4 hydroxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( AT1G69640 ) or ( AT1G14290 ) or ( SUR2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( dihydrosphingosine C-4 hydroxylase )</html:p>
<html:p>SUBSYSTEM: sphingolipid biosynthesis (plants)</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.14.-.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRO__45__SPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__4" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MAOA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amine oxidase A )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTP_TO_CMP_COF_RXN" name="CTP_TO_CMP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty-acid amide hydrolase )</html:p>
<html:p>SUBSYSTEM: anandamide degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7598" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROLINE__45__RACEMASE__45__RXN" name="Proline racemase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( prdF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: interconversion of arginine, ornithine and proline (Stickland reaction)</html:p>
<html:p>PROTEIN_CLASS: 5.1.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__PROLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FPPSYN__45__RXN" name="geranyltranstransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FPS ) or ( GGPPS ) or ( LeFPS1 ) or ( hbgg ) or ( ispA ) or ( NA ) or ( FPP1 ) or ( FPS2 ) or ( FDPS ) or ( FPS1 ) or ( GGPS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( prenyltransferase subunit ) or ( farnesyl-pyrophosphate synthase ) or ( NA ) or ( NA ) or ( farnesyl pyrophosphate synthetase FPP synthetase FPS farnesyl diphosphate synthetase ) or ( Erg20 ) or ( NA ) or ( farnesyl pyrophosphate synthetase ) or ( NA ) or ( geranylgeranyl pyrophosphate synthetase )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: linalool biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of ergosterol biosynthesis</html:p>
<html:p>SUBSYSTEM: polyisoprenoid biosynthesis (E. coli)</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NADP__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( maeB ) or ( me1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MaeB ) or ( NADP malic enzyme )</html:p>
<html:p>SUBSYSTEM: C4 photosynthetic carbon assimilation cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.40</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9805" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( CYP94C1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: cutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10514" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_910__45__EPOXY__45__18__45__HYDROXYSTEARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9804" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.11.-.-</html:p>
<html:p>SIDE: __124__Alcohols__124__</html:p>
<html:p>SIDE: A__45__LIPID__45__HYDROPEROXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__LIPID__45__HYDROPEROXIDE" stoichiometry="1"/>
      <speciesReference species="OLEATE__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10514" stoichiometry="1"/>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9807" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10515" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_91018__45__TRIHYDROXYSTEARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9806" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.-</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10514" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10515" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GKI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gckA ) or ( garK ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerate kinase ) or ( glycerate kinase I ) or ( NA )</html:p>
<html:p>SUBSYSTEM: D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>SUBSYSTEM: formaldehyde assimilation I (serine pathway)</html:p>
<html:p>SUBSYSTEM: superpathway of D-glucarate and D-galactarate degradation</html:p>
<html:p>SUBSYSTEM: D-glucarate degradation</html:p>
<html:p>SUBSYSTEM: 2-O-&amp;alpha;-mannosyl-D-glycerate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R63__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: purine degradation III (anaerobic)</html:p>
<html:p>SUBSYSTEM: purine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__60" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMIMINO__45__GLYCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9800" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Baat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bile acid-CoA:amino acid N-acyltransferase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.65</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: TAURINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
      <speciesReference species="TAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__3743" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9802" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT1G72970 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cutin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_16__45__HYDROXYPALMITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10512" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBINAMIDEKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cobP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CobP )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.156</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R9__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gallate degradation III (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9000" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9459" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9460" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9003" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: ubiquinone-6 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__4__45__hydroxybenzoate__124__" stoichiometry="1"/>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HEXAPRENYL__45__4__45__HYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROGBIOSYN__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( gpsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GpsA )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>SUBSYSTEM: phosphatidylglycerol biosynthesis I (plastid)</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.94</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYLESTERASE__45__RXN" name="Carboxylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( bioH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carboxylesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Carboxylic__45__esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__SULFOBENZOATE__45__34__45__DIOXYGENASE__45__RXN" name="4-sulfobenzoate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( psbC and psbA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-sulfobenzoate 3,4-dioxygenase reductase component and PsbA )</html:p>
<html:p>SUBSYSTEM: 4-toluenesulfonate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: SO3</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__257" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="_3__45__4__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9831" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( pchF and pchC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( p-ethylphenol methylhydroxylase subunit 2 and p-ethylphenol methylhydroxylase subunit 1 )</html:p>
<html:p>SUBSYSTEM: 4-ethylphenol degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.17.99.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10596" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10597" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9832" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( chnA ) or ( ebA309 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 4-ethylphenol degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10597" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10598" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLASPARTATE__45__MUTASE__45__RXN" name="Methylaspartate mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( mamA ) or ( glmS and glmE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate mutase &amp;epsilon; subunit and glutamate mutase &amp;sigma; subunit ) or ( component S of glutamate mutase and GlmE )</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis III</html:p>
<html:p>SUBSYSTEM: glutamate degradation VIII (to propionate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VI (to pyruvate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII (to butyrate)</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__THREO__45__3__45__METHYL__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9830" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdxr and Cyp24a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA and cytochrome P450 24A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CALCITRIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10577" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9049" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( dHG-6-OMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( desoxyhemigossypol-6-O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: gossypol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9524" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9528" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9835" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tioL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-ethylphenol degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10600" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__201" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9836" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1072" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10601" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9833" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( xccA and xccB and xccC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxyacetophenone carboxylase biotin carboxylase subunit and 4-hydroxyacetophenone carboxylase biotin carboxyl carrier subunit and 4-hydroxyacetophenone carboxylase carboxylase subunit )</html:p>
<html:p>SUBSYSTEM: 4-ethylphenol degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10598" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10599" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9834" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( acsA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 4-ethylphenol degradation (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10599" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10600" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9839" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AlgE4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: alginate biosynthesis I</html:p>
<html:p>SUBSYSTEM: alginate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CPD__45__10585</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1828" stoichiometry="1"/>
      <speciesReference species="CPD__45__10585" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALGINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOLATEDEHYDRO__45__RXN" name="Glycolate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( glcF and glcE and glcD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycolate oxidase, predicted iron-sulfur subunit and glycolate oxidase, predicted FAD-linked subunit and glycolate oxidase, predicted FAD-binding subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of glycol metabolism and degradation</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation II</html:p>
<html:p>SUBSYSTEM: glycolate and glyoxylate degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.14</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__162__45__RXN" name="Glycine/sarcosine/dimethylglycine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GSDMT monomer )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis V (from glycine)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.162</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9837" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1075" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10596" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAPHTHOATE__45__SYN__45__RXN" name="naphthoate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( menB ) or ( menB ) or ( menB ) or ( menB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( naphthoate synthase monomer ) or ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis II (plants)</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: 1,4-dihydroxy-2-naphthoate biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-7 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-6 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-8 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of demethylmenaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of phylloquinone biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-9 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-10 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-13 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-12 biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of menaquinone-11 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.36</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__6972" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9925" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNDECARBOX__45__RXN" name="Ornithine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ODC1 ) or ( speF ) or ( speC ) or ( speC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine decarboxylase subunit ) or ( SpeF ) or ( ornithine decarboxylase subunit ) or ( SpeC )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URKI__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( udk )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2361" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( mpl )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYLMURAMATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALA__45__D__45__GLU__45__MESOA2PM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__AAGM__45__DIAMINOHEPTANEDIOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R621__45__RXN" name="Nitric oxide dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( hmp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fused nitric oxide dioxygenase and dihydropteridine reductase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.12.17</html:p>
<html:p>COFACTOR: PROTON</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NITRIC__45__OXIDE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9820" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: indigo biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOXYL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10525" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9821" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cardenolide glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10537" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10536" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__83__45__RXN" name="Dolichyl-phosphate &amp;beta;-D-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DPM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.83</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9822" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cardenolide glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: CPD__45__10542</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10537" stoichiometry="1"/>
      <speciesReference species="CPD__45__10542" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10538" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9823" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cardenolide glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10538" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10539" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9824" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cardenolide glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: CPD__45__10542</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10537" stoichiometry="1"/>
      <speciesReference species="CPD__45__10542" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10540" stoichiometry="1"/>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9825" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( IAMT1 ) or ( IAMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE_ACETATE_AUXIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10546" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGTPTRIPHYDRO__45__RXN" name="Deoxyguanosinetriphosphate triphosphohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( dgt )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Dgt )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.5.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYGUANOSINE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9826" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: cardenolide glucosides biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: D__45__FUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__FUCOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__10537" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10538" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trpA ) or ( trpA ) or ( trpA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase, &amp;alpha; subunit ) or ( tryptophan synthase subunit &amp;alpha; ) or ( &amp;alpha; subunit of tryptophan synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: GAP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE__45__3__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3DJ__45__11230" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Sgpl1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingosine phosphate lyase 1 )</html:p>
<html:p>SUBSYSTEM: sphingosine and sphingosine-1-phosphate metabolism</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PHOSPHORYL__45__ETHANOLAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD3DJ__45__11366" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__292" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9829" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP2R1 and POR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA and cytochrome P450 2R1 )</html:p>
<html:p>SUBSYSTEM: 1,25-dihydroxyvitamin D3 biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VITAMIN_D3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CALCIDIOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="YIAE2__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ghrB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GhrB )</html:p>
<html:p>SUBSYSTEM: ketogluconate metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__IDONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPMANACATRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( rffM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: enterobacterial common antigen biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__MANNACA" stoichiometry="1"/>
      <speciesReference species="GLCNAC__45__PP__45__LIPID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="C55__45__PP__45__GLCNAC__45__MANNACA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN490__45__3641" name="proline,2-oxoglutarate-4-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( D78338 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.2</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__HYDROXY__45__L__45__PROLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__20__45__RXN" name="(R)-limonene synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPS-Lim ) or ( f-E&amp;alpha;bis ) or ( TPS-Pin )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( limonene synthase ) or ( (E)-&amp;alpha;-bisabolene synthase ) or ( pinene synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8785" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__13__45__RXN" name="Mannose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( VTC1 ) or ( cpsB ) or ( PH0925 ) or ( algA ) or ( GMPP ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( GDP-mannose pyrophosphorylase &amp;alpha; subunit and GDP-mannose pyrophosphorylase &amp;beta; subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis II</html:p>
<html:p>SUBSYSTEM: alginate biosynthesis I</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: alginate biosynthesis II</html:p>
<html:p>SUBSYSTEM: ascorbate biosynthesis I (L-galactose pathway)</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis II</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>SUBSYSTEM: mannosylglycerate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.13</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__1__45__PHOSPHAT__45__RXN" name="Glucose-1-phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( yfbT ) or ( yihX ) or ( ybiV ) or ( yigL ) or ( agp ) or ( yidA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sugar phosphatase ) or ( &amp;alpha;-D-glucose-1-phosphatase ) or ( sugar phosphatase ) or ( sugar phosphatase ) or ( Agp ) or ( sugar phosphatase )</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__D__45__Glucose__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R107__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: protocatechuate degradation I (meta-cleavage pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__87" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2542" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9065" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( phzO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: 2-hydroxyphenazine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9522" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9547" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9066" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: 2-hydroxyphenazine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9547" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9546" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9069" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BAA13145 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-sorbosone dehydrogenase subunit ) or ( L-sorbose/L-sorbosone dehydrogenase 64.5 kD subunit and L-sorbose/L-sorbosone dehydrogenase 62.5 kD subunit )</html:p>
<html:p>SUBSYSTEM: 2-keto-L-gulonate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9056" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__377" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__34__45__RXN" name="6,7-dihydropteridine reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( nfsB ) or ( hmp )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydropteridine reductase monomer ) or ( fused nitric oxide dioxygenase and dihydropteridine reductase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.34</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5678__45__TETRAHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_67__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOACETYLTRAN__45__RXN" name="Galactoside O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( lacA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactoside O-acetyltransferase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.18</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__D__45__Galactosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__Acetyl__45__Beta__45__D__45__Galactosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9857" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tfdEI ) or ( clcD ) or ( tcbE ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dienelactone hydrolase I ) or ( dienelactone hydrolase ) or ( NA ) or ( dienelactone hydrolase )</html:p>
<html:p>SUBSYSTEM: 3,5-dichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__2__45__CHLORO__45__4__45__CARBOXYMETHYLENEBUT__45__2__45__EN__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__CHLOROMALEYLACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9858" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( tecA4 and tecA2 and tecA3 and tecA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorobenzene dioxygenase ) or ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit )</html:p>
<html:p>SUBSYSTEM: chlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLOROBENZENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10609" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9855" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tfdC ) or ( tcbC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( chlorocatechol 1,2-dioxygenase )</html:p>
<html:p>SUBSYSTEM: 3,5-dichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_35__45__DICHLOROCATECHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10632" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9856" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( clcB ) or ( tfdDI ) or ( tcbD ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase )</html:p>
<html:p>SUBSYSTEM: 3,5-dichlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CL__45__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10632" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__2__45__CHLORO__45__4__45__CARBOXYMETHYLENEBUT__45__2__45__E" stoichiometry="1"/>
      <speciesReference species="CL__45__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9853" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or ( tecA4 and tecA2 and tecA3 and tecA1 ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorobenzene dioxygenase ) or ( chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit and chlorobenzene dioxygenase terminal oxidase large subunit and chlorobenzene dioxygenase terminal oxidass ferredoxin subunit and chlorobenzene dioxygenase terminal oxidase small subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: 1,3-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10603" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10604" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9028" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( phzE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phenazine-1-carboxylate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.86</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHORISMATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9517" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9854" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( tecB ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( dichlorobenzene cis-dihydrodiol dehydrogenase subunit ) or ( chlorobenzene cis-dihydrodiol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: 1,3-dichlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10604" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_35__45__DICHLOROCATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9851" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Baat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bile acid-CoA:amino acid N-acyltransferase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.65</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="CPD__45__10556" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOCHENODEOXYCHOLIC_ACID" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9852" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Baat )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bile acid-CoA:amino acid N-acyltransferase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.65</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: TAURINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10556" stoichiometry="1"/>
      <speciesReference species="TAURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__7283" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9859" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( cbsB ) or ( tecB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA ) or ( dichlorobenzene cis-dihydrodiol dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: chlorobenzene degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9151" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2382" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( trpB ) or ( trpB1 ) or ( trpB2 ) or ( trpB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan synthase &amp;beta; subunit ) or ( &amp;beta; subunit of tryptophan synthase ) or ( tryptophan synthase &amp;beta;2 subunit ) or ( tryptophan synthase, &amp;beta; subunit )</html:p>
<html:p>SUBSYSTEM: superpathway of phenylalanine, tyrosine, and tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: tryptophan biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of chorismate</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.20</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9861" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( tfdDI ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chloromuconate cycloisomerase subunit ) or ( chloromuconate cycloisomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__CL__45__MUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10639" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9036" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT71G1 ) or ( UGT73K1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triterpene sapogenin UDP-glucosyltransferase ) or ( triterpene sapogenin UDP-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9481" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Hederagenin__45__Monoglucosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9860" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( clcA ) or ( tfdC ) or ( tcbC ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chlorocatechol 1,2-dioxygenase subunit ) or ( NA ) or ( NA ) or ( chlorocatechol 1,2-dioxygenase )</html:p>
<html:p>SUBSYSTEM: 3-chlorocatechol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9151" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__CL__45__MUCONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9035" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT71G1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triterpene sapogenin UDP-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9483" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Medicagenate__45__Monoglucosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9032" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: phenazine-1-carboxylate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9521" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9520" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9031" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( phzF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-2,3-dihydro-3-hydroxy-anthranilate isomerase subunit )</html:p>
<html:p>SUBSYSTEM: phenazine-1-carboxylate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9518" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9521" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9030" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( phzD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: phenazine-1-carboxylate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9517" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9518" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9844" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdxr and Cyp27a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 27A1 and NA )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.40</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10587" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1834" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PURIDYLTRANS__45__RXN" name="UTP--glucose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UGP ) or ( Ugp2 ) or ( galU ) or ( galU and galF ) or (  ) or ( USP ) or ( UGP2 ) or ( gtaB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose pyrophosphorylase ) or ( UDP-glucose pyrophosphorylase 2 ) or ( NA ) or ( GalU and predicted subunit with GalU ) or ( NA ) or ( NA ) or ( UDP-glucose pyrophosphorylase subunit ) or ( NA )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: sucrose degradation to ethanol and lactate (anaerobic)</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis II (from UDP-D-Glucose)</html:p>
<html:p>SUBSYSTEM: L-ascorbate biosynthesis VI</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>SUBSYSTEM: sucrose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9845" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Amacr )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;alpha;-methylacyl-CoA racemase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__72" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10588" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9846" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Acox2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (25S)-3&amp;alpha;,7&amp;alpha;,12&amp;alpha;-trihydroxy-5&amp;beta;-cholestanoyl-CoA dehydrogenase subunit )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10588" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10589" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9847" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal multifunctional enzyme type 2 subunit )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.107</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10589" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10590" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9840" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1d1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;Delta;4-3-oxosteroid 5&amp;beta;-reductase )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1087" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9037" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73K1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triterpene sapogenin UDP-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7610" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Soyasapogenol__45__B__45__Monoglucosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9841" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Akr1c9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&amp;alpha;-hydroxysteroid dehydrogenase (A-specific) )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.213</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10548" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7238" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9038" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT73K1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triterpene sapogenin UDP-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: saponin biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9482" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Soyasapogenol__45__E__45__Monoglucosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9842" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdxr and Cyp27a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 27A1 and NA )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.15</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7238" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10586" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9843" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Fdxr and Cyp27a1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome P450 27A1 and NA )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.161</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10586" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10587" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN1F__45__775" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( At5g17050 ) or ( pGUT8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)</html:p>
<html:p>SUBSYSTEM: anthocyanin biosynthesis (pelargonidin 3-O-glucoside, cyanidin 3-O-glucoside)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.115</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__591" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD1F__45__766" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9848" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Hsd17b4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal multifunctional enzyme type 2 subunit )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10590" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10591" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARG__45__OXIDATION__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: arginine degradation VIII (arginine oxidase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__824" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__884" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IspH ) or ( ispH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__882" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GcpE ) or ( ispG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA ) or ( NA )</html:p>
<html:p>SUBSYSTEM: superpathway of geranylgeranyldiphosphate biosynthesis II (via MEP)</html:p>
<html:p>SUBSYSTEM: methylerythritol phosphate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.17.4.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Protein__45__Disulfides__124__</html:p>
<html:p>SIDE: __124__Protein__45__Dithiols__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2C__45__METH__45__D__45__ERYTHRITOL__45__CYCLODIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXY__45__METHYL__45__BUTENYL__45__DIP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="VALINE__45__PYRUVATE__45__AMINOTRANSFER__45__RXN" name="Valine--pyruvate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( avtA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.66</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSTEINE__45__S__45__METHYLTRANSFERASE__45__RXN" name="Homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AT3g25900 ) or ( mmuM ) or ( AT3g63250 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homocysteine S-methyltransferase ) or ( NA ) or ( homocysteine S-methyltransferase )</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.10</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__3441" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ygiN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( quinol monooxygenase monomer )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MENADIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3766" stoichiometry="1"/>
      <speciesReference species="SUPER__45__OXIDE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAMDECARB__45__RXN" name="Adenosylmethionine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( speD ) or ( AMD1 ) or ( speD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( &amp;beta; cleavage product of SpeD and &amp;alpha; cleavage product of SpeD ) or ( S-adenosylmethionine decarboxylase &amp;alpha; subunit and S-adenosylmethionine decarboxylase &amp;beta; subunit ) or ( adenosylmethionine decarboxylase proenzyme )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and polyamine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.50</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9045" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP706B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NA )</html:p>
<html:p>SUBSYSTEM: gossypol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1722" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9523" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9850" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( Scp2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol carrier protein 2 )</html:p>
<html:p>SUBSYSTEM: bile acid biosynthesis, neutral pathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.176</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PROPIONYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__10591" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10556" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
