<?xml version="1.0"  encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="HUMAN_metabolic_network_metabolic_network" name="Homo sapiens">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
  <species id="GLUCURONATE" name="D-glucuronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__313" name="1,3-diaminopropane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Monophosphates__124__" name="a ribonucleoside monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DIHYDROXY__45__PHENYLALANINE" name="L-dopa" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBON__45__MONOXIDE" name="CO" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Amino__45__Acids__124__" name="a D-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPID" name="lipid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1087" name="7&amp;alpha;-hydroxycholest-4-en-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GAMMA__45__GLUTAMYLCYSTEINE" name="L-&amp;gamma;-glutamylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__EPINEPHRINE" name="adrenaline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP" name="GDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="APS" name="adenosine 5&apos;-phosphosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" name="an L-1-phosphatidyl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__SEDOHEPTULOSE__45__7__45__P" name="D-sedoheptulose-7-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROFOLATE" name="7,8-dihydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSYLCERAMIDE" name="&amp;beta;-D-galactosyl-1,4-N-acetyl-&amp;beta;-D-glucosaminyl-1,3-&amp;beta;-D-galactosyl-1,4-&amp;beta;-D-glucosylceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acceptor__124__" name="an oxidized electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ILE" name="L-isoleucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINAMINE" name="S-adenosyl-L-methioninamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z13E__45__15S__45__9__45__ALPHA11__45__ALPHA15__45__TRIHY" name="(5z,13e)-(15s)-9-&amp;alpha;,11-&amp;alpha;,15-trihydroxyprosta-5,13-dienoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F6" name="N4-{N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,3)-[N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,6)]-&amp;beta;-D-mannosyl-(1,4)-N-acetyl-&amp;beta;-D-glucosaminyl-(1,4)-[&amp;alpha;-L-fucosyl-(1,6)]-N-acetyl-&amp;beta;-D-glucosaminyl}asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__302" name="D-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARG" name="L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__CHLORO__45__24__45__DINITROBENZENE" name="1-chloro-2,4-dinitrobenzene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMP" name="inosine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROCOLLAGEN__45__5__45__HYDROXY__45__L__45__LYSINE" name="procollagen-5-hydroxy-L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNOSE" name="D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__11__45__Beta__45__Hydroxysteroids1__124__" name="an 11-&amp;beta;-hydroxysteroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__METHYLPHENYLETHANOLAMINE" name="N-methylphenylethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOPROTEIN__45__PHOSPHO__45__D__45__MANNOSE" name="glycoprotein-phospho-D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__2__45__HYDROXYACYLSPHINGOSINE" name="2-(2-hydroxyacyl)sphingosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__335" name="(R)-3-hydroxybutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NUC__45__5__45__PHOSPHATE" name="a nucleoside-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOAMIDE" name="lipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__332" name="dihydrozeatin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" name="a protein L-&amp;beta;-isoaspartate &amp;alpha;-methyl ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__6" name="ubiquinone-6" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" name="formyl-L-methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ASPARTATE" name="L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ASN" name="L-asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALONATE__45__S__45__ALD" name="malonate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINONE__45__8" name="ubiquinone-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CYSTATHIONINE" name="cystathionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Donor__45__H2__124__" name="a reduced electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" name="D-myo-inositol (1,3,4)-trisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYPOTAURINE" name="hypotaurine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL" name="pyridoxal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" name="D-myo-inositol (3)-monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__Arylethylamines__124__" name="a 2-arylethylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYADENOSINE" name="deoxyadenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__FORMYLMETHIONINE" name="N-formyl-L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATP" name="ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" name="UDP-N-acetyl-D-galactosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSINE5TRIPHOSPHO5ADENOSINE" name="5&apos;,5&apos;-diadenosine triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSE" name="&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA11__45__ALPHA__45__EPOXY__45__15__45__HYDROXYTHROMBA" name="(5Z,13E)-(15S)-9&amp;alpha;,11&amp;alpha;-epoxy-15-hydroxythromboxa-5,13-dienoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUCOSAMINYL__45__ETCETERA__45__MANNOSYL__45__R" name="(N-acetyl-&amp;beta;-D-glucosaminyl-1,2)-&amp;alpha;-D-mannosyl-1,3-(&amp;beta;-N-acetyl-D-glucosaminyl-1,2-&amp;alpha;-D-mannosyl-1,6)-&amp;beta;-D-mannosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KERATAN" name="keratan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOLLATE" name="glycolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH__45__P__45__OR__45__NOP" name="NAD(P)H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="T2__45__DECENOYL__45__COA" name="trans-&amp;Delta;2-decenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__TETRADECANOYLGLYCYL__45__PEPTIDE" name="N-tetradecanoylglycyl-peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__316" name="reduced riboflavin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" name="dTDP-4-dehydro-6-deoxy-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDPDIACYLGLYCEROL" name="a CDP-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4619" name="cis-zeatin-9-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__LACTATE" name="D-lactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" name="a 2,3,4-saturated fatty acyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__352" name="estradiol-17&amp;beta;" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPROSTADIL" name="(13E)-(15S)-11-&amp;alpha;,15-dihydroxy-9-oxoprost-13-enoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F" name="N(4)-{N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,3)-[N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,6)]-&amp;beta;-D-mannosyl-(1,4)-N-acetyl-&amp;beta;-D-glucosaminyl-(1,4)-[&amp;alpha;-L-fucosyl-(1,3)]-N-acetyl-&amp;beta;-D-glucosaminyl}asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CANAVANINE" name="canavanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__1__45__ARSENATE" name="ribose-1-arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__3__45__HYDROXYACYL__45__COA" name="a (3S)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TYR" name="L-tyrosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARSENATE" name="arsenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5678__45__TETRAHYDROPTERIDINE" name="5,6,7,8-tetrahydropteridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4620" name="cis-zeatin-O-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETO__45__6__45__AMINO__45__CAPROATE" name="2-keto-6-aminocaproate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4621" name="dihydrozeatin-9-N-glucoside-O-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4622" name="trans-zeatin-O-glucoside-7-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" name="4,4-dimethyl-5-&amp;alpha;-cholesta-8,14,24-trien-3-&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8188" name="glycoprotein N-acetyl-D-galactosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THREO__45__DS__45__ISO__45__CITRATE" name="D-isocitrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE" name="N-acetyl-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LYS" name="L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENYLOSUCC" name="adenylo-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__BETA__45__D__45__GALACTOSYL__45__2__45__2__45__HYDROXYACYLS" name="1-(&amp;beta;-D-galactosyl)-2-(2-hydroxyacyl)sphingosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__342" name="5&amp;alpha;-Androstane-3,17-dione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUMP" name="dUMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1242" name="3-keto-&amp;beta;-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DOPACHROME" name="L-dopachrome" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOPORPHYRIN_IX" name="protoporphyrin IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="A__45__3__45__OXO__45__ACYL__45__COA" name="a 3-oxo-acyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALLO__45__THR" name="allothreonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__371" name="1-octanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UROPORPHYRINOGEN__45__III" name="uroporphyrinogen-III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__HYDROXYPHYTANOYL__45__COA" name="2-hydroxyphytanoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCERATE" name="D-glycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__374" name="sepiapterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIETHYLTHIOPHOSPHATE" name="diethylthiophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__L__45__1__45__phosphatidyl__45__inositols__124__" name="an L-1-phosphatidyl-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__THYROXINE" name="L-thyroxine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__MERCAPTO__45__PYRUVATE" name="3-mercaptopyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUTACONYL__45__COA" name="glutaconyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2K__45__ADIPATE" name="&amp;alpha;-ketoadipate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_56__45__DIHYDROXYINDOLE__45__2__45__CARBOXYLATE" name="5,6-dihydroxyindole-2-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="POLYPEPTIDE" name="a polypeptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__369" name="L-iditol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORSSMAN__45__HAPTEN" name="forssman hapten" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4604" name="benzyladenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4607" name="benzyladenine-7-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4602" name="isopentenyladenine-7-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__L__45__lysine__124__" name="a protein L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4603" name="isopentenyladenine-9-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIOTHYRONINE" name="L-triiodothyronine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Keto__45__Acid__124__" name="a keto acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHOLESTEROL" name="cholesterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__3__45__Oxo__45__5__45__Beta__45__Steroids__124__" name="a 3-oxo-5-&amp;beta;-steroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__BETA__45__GLUCOSAMINYLAMINE" name="N-acetyl-&amp;beta;-glucosaminylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4609" name="kinetin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4608" name="benzyladenine-9-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRANS__45__POLYISOPRENYL__45__PP" name="a trans-polyisoprenyln-PP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4610" name="kinetin-7-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXY__45__ACETONE__45__PHOSPHATE" name="dihydroxyacetone phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYDROXYMETHYLBILANE" name="hydroxymethylbilane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Triphosphates__124__" name="a nucleoside triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC" name="&amp;beta;-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SQUALENE" name="squalene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4617" name="dihydrozeatin-O-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4618" name="cis-zeatin-7-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4615" name="dihydrozeatin-7-N-dihydrozeatin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4616" name="dihydrozeatin-9-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4613" name="trans-zeatin-9-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4614" name="trans-zeatin-O-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4611" name="kinetin-9-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4612" name="trans-zeatin-7-N-glucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Carboxylates__124__" name="a carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__190" name="N-acetylglucosaminyl-diphosphodolichol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCANO__45__26__45__ETCETERA__45__GLYCOPROTEIN" name="glycano-(2,6-&amp;alpha;-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__194" name="4-nitrophenyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__195" name="octanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__MALEYL__45__ACETOACETATE" name="4-maleyl-acetoacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYLARYLAMINE" name="N-acetylarylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__SULFINYL__45__PYRUVATE" name="3-sulfinyl-pyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LONG__45__CHAIN__45__KETONE" name="a ketone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__396" name="1-methylnicotinamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="QUINOLINATE" name="quinolinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__L__45__FUCOSYL__45__12__45__BETA__45__D__45__GALACTOSYL__45__R" name="&amp;alpha;-L-fucosyl-1,2-&amp;beta;-D-galactosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Quinones__124__" name="a quinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYLCOBALAMIN" name="coenzyme B12" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Fatty__45__Acids__124__" name="a fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HISTAMINE" name="histamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3945" name="(22&amp;alpha;)-hydroxy-campest-4-en-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3946" name="(22&amp;alpha;)-hydroxy-5&amp;alpha;-campestan-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SACCHAROPINE" name="saccharopine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__21__45__Hydroxysteroids__124__" name="a 21-hydroxysteroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOIC__45__ACID" name="lipoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__S__45__Substituted__45__Glutathione__124__" name="a glutathione-toxin conjugate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__181" name="4-methylumbelliferyl acetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__182" name="4-methylumbelliferone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__189" name="CMP-N-acylneuraminate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYGUANOSINE" name="deoxyguanosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__385" name="1,2-benzoquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__387" name="iodide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__596" name="NG,NG-dimethyl-L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP" name="UDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__Oxo__45__Acids__124__" name="a 2-oxo acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PORPHOBILINOGEN" name="porphobilinogen" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__91__3__45__METHYL__45__2__45__OXOBUTANOATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACYL__45__COA" name="an acyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P__45__NITROPHENOL" name="4-nitrophenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRUCTOSE__45__16__45__DIPHOSPHATE" name="fructose-1,6-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__D__45__MANNOSYL__45__13__45__R1__45__BETA__45__D__45__MANNOSY" name="&amp;alpha;-D-mannosyl-1,3-(R1)-&amp;beta;-D-mannosyl-R2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_23__45__DIPHOSPHOGLYCERATE" name="2,3-diphosphoglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Thiopurines__124__" name="a thiopurine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Fatty__45__Aldehydes__124__" name="a fatty aldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHENYL__45__PYRUVATE" name="phenylpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NOREPINEPHRINE" name="noradrenaline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYL__45__HOMO__45__CYS" name="S-adenosyl-L-homocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ARGININO__45__SUCCINATE" name="L-arginino-succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNOSE__45__1P" name="&amp;alpha;-D-mannose 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MET" name="L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" name="glycogen" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__LACTATE" name="L-lactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TETRA__45__H__45__BIOPTERIN" name="tetrahydrobiopterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Semiquinones__124__" name="a semiquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AN__45__ALPHA__45__L__45__FUCOSIDE" name="&amp;alpha;-L-fucoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Reduced__45__Quinones__124__" name="a hydroquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEPHOSPHO__45__COA" name="dephospho-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PANTOTHENATE" name="pantothenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Alkyl__45__acetyl__45__glycero__45__phosphocholines__124__" name="a 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__HYDROXYMETHYLGLUTATHIONE" name="S-hydroxymethylglutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Myelin__45__N__45__o__45__methyl__45__arginines__124__" name="[myelin basic protein]-N&amp;omega;-methyl-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MI__45__HEXAKISPHOSPHATE" name="phytate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Sphingomyelins__124__" name="a sphingomyelin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Beta__45__Lactams__124__" name="a &amp;beta;-lactam" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BETA__45__HYDROXYANDROST__45__5__45__EN__45__17__45__ONE__45__3__45__SULFAT" name="3-&amp;beta;-hydroxyandrost-5-en-17-one 3-sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Non__45__Glucur__45__Glucuronoside__45__Acceptors__124__" name="a non-glucuronosylated glucuronoside acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACYL__45__SN__45__GLYCEROL__45__3P" name="a 1-acyl-sn-glycerol-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROT__45__CYS" name="a protein L-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" name="5&amp;alpha;-cholesta-7,24-dien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N2__45__SUCCINYLGLUTAMATE" name="N2-succinylglutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OROTATE" name="orotate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC__45__6__45__P" name="&amp;beta;-D-glucose-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__METHYL__45__THF" name="5-methyl-THF" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__3__45__Oxo__45__5__45__Alpha__45__Steroids__124__" name="a 3-oxo-5-&amp;alpha;-steroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__535" name="&amp;beta;-D-fructose 2,6-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HS" name="hydrogen sulfide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__OXOBUTANOATE" name="2-oxobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CYS__45__GLY" name="cysteinylglycine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BETA__45__D__45__GALACTOSYL__45__R" name="&amp;beta;-D-galactosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXINE__45__5P" name="pyridoxine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBAMOYL__45__P" name="carbamoyl-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CERAMIDE" name="a ceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCANO__45__13__45__ETCETERA__45__GLYCOPROTEIN" name="glycano-1,3-(N-acetyl-&amp;alpha;-D-galactosaminyl)-glycoprotein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HX" name="HX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUDP" name="dUDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ERYTHROSE__45__4P" name="D-erythrose-4-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PURINE" name="purine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__PHOSPHATIDYL__45__1D__45__MYO__45__INOSITOL__45__34__45__BISPH" name="1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GAP" name="D-glyceraldehyde-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__548" name="S-formylglutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OCTANOYL__45__COA" name="octanoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__ACETO__45__LACTATE" name="2-acetolactate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__550" name="N-sulfo-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6124" name="1-pyrroline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6121" name="1-(3-aminopropyl)-4-aminobutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Cholesterol__45__esters__124__" name="a cholesterol ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROCOLLAGEN__45__L__45__PROLINE" name="procollagen-L-proline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aryl__45__Dialkyl__45__Phosphate__124__" name="an aryl dialkyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" name="all-trans-heptaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ARACHIDONIC_ACID" name="arachidonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__N__45__ACETYLNEURAMINYL__45__ETCETERA" name="&amp;alpha;-N-acetylneuraminyl-(2->3)-&amp;beta;-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BETA__45__D__45__GALACTOSYL__45__14__45__N__45__ACETYL__45__ETCETERA" name="&amp;beta;-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__TRYPTOPHAN" name="D-tryptophan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__177" name="1-phosphatidyl-1D-myo-inositol 3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" name="4-carboxyaminoimidazole ribonucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__FORMYLKYNURENINE" name="N-formylkynurenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOPORPHYRINOGEN" name="protoporphyrinogen IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__THIOURIDINE" name="2-thiouridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7241" name="25-hydroxycholesterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__171" name="dolichyl &amp;beta;-D-mannosyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4184" name="4&amp;alpha;-methyl-cholesta-8-enol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__3__45__oxo__45__D5__45__steroids__124__" name="a 3-oxo-&amp;delta;5-steroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__2__45__METHYLACYL__45__COA" name="(2S)-2-methylacyl-coa" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Orthophosphoric__45__Monoesters__124__" name="a phosphate monoester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__557" name="a protein-Nw-(ADP-D-ribosyl)-L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHLORDECONE" name="chlordecone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" name="2-amino-3-carboxymuconate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" name="D-myo-inositol (1,4,5)-trisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Trans__45__3__45__enoyl__45__CoAs__124__" name="a trans-3-enoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="QUININE" name="quinine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__GLUCURONATE" name="UDP-D-glucuronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCERALD" name="glyceraldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOPROTEIN__45__ETCETERA__45__GALACTOSAMINYL__45__GAL" name="glycoprotein N-acetyl-&amp;alpha;-D-galactosaminyl-(1,3)-[&amp;alpha;-L-fucosyl-(1,2)]-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7246" name="N-acetyl-&amp;alpha;-D-galactosamine 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4187" name="7-dehydro-cholesterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4186" name="lathosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NICOTINAMIDE_NUCLEOTIDE" name="nicotinamide mononucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SOLANESYL__45__PYROPHOSPHATE" name="all-trans-nonaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__N__45__Acetyl__45__2__45__Arylethylamines__124__" name="an N-acetyl-2-arylethylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMINO__45__OXOBUT" name="2-amino-3-oxobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__166" name="dolichyl &amp;beta;-D-glucosyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MAL" name="malate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__569" name="N-acetylputrescine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__568" name="N1-acetylspermidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYURIDINE" name="deoxyuridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__576" name="N-acyl-L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__574" name="biotin amide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7239" name="(24S)-24-hydroxycholesterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__91__eIF__45__5A__93____45__deoxyhypusine" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__PHOSPHATIDYL__45__MYO__45__INOSITOL__45__34__45__BISPHOSP" name="1-phosphatidyl-myo-inositol 3,4-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__ETCETERA__45__L__45__ASPARAGINE" name="N4-(&amp;beta;-N-acetyl-D-glucosaminyl)-L-asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDP__45__ETHANOLAMINE" name="CDP-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BILIVERDINE" name="biliverdin-IX-&amp;alpha;" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Steryl__45__Esters__124__" name="a steryl-ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__ANTHRANILATE" name="3-hydroxyanthranilate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MEVALONATE" name="(R)-mevalonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="T2__45__C4__45__DECADIENYL__45__COA" name="trans-&amp;Delta;2, cis-&amp;Delta;4-decadienoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXIDIZED__45__GLUTATHIONE" name="glutathione disulfide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__822" name="N2-succinyl-L-glutamate 5-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SPERMINE" name="spermine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="STEAROYL__45__COA" name="stearoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__624" name="N-acylneuraminate 9-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIMETHYL__45__GLYCINE" name="dimethylglycine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" name="phosphoribosyl-formamido-carboxamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XANTHOSINE" name="xanthosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TMP" name="dTMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="G3P" name="3-phosphoglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRU" name="D-fructose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__91__eIF__45__5A__93____45__lysine" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__TRIMETHYLAMMONIOBUTANAL" name="4-trimethylammoniobutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4441" name="cis-zeatin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__611" name="thiamin triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBAMYUL__45__L__45__ASPARTATE" name="N-carbamoyl-L-aspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2961" name="6-phospho-D-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CMP__45__N__45__ACETYL__45__NEURAMINATE" name="CMP-N-acetylneuraminate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALDOSE" name="aldose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Plant__45__Ceramide__45__Phosphate__124__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5725" name="tetrahydrofolate-L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Deoxy__45__Ribonucleoside__45__Diphosphates__124__" name="a 2&apos;-deoxyribonucleoside diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleotides__124__" name="a nucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ESTRONE__45__SULFATE" name="estrone-sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ETHANOL__45__AMINE" name="ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROCOLLAGEN__45__L__45__LYSINE" name="procollagen-L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__650" name="3-hydroxybutyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9650" name="all-trans-dodecaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GALACTOSAMINY" name="&amp;beta;-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Galactose__124__" name="D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Fatty__45__Acyl__45__CoA__124__" name="a fatty acyl CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__ADP__45__D__45__Ribosyl__45__Acceptors__124__" name="a ADP-D-ribosyl acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__BETA__45__HYDROXYANDROST__45__5__45__EN__45__17__45__ONE" name="3-&amp;beta;-hydroxyandrost-5-en-17-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LACTOSE" name="lactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__METHYL__45__BUTYRYL__45__COA" name="S-2-methyl-butyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__649" name="sphinganine 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__ANDROSTAN__45__3BETA17BETA__45__DIOL" name="5-&amp;alpha;-androstan-3&amp;beta;,17&amp;beta;-diol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N2__45__SUCCINYLORNITHINE" name="N2-succinyl-L-ornithine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" name="UDP-N-acetyl-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LACTALD" name="L-lactaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" name="geranylfarnesyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__KETOBUTYRATE" name="acetoacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__HYDROXY__45__3__45__KETO__45__5__45__METHYLTHIO__45__1__45__PHOSPHOP" name="2-hydroxy-3-keto-5-methylthio-1-phosphopentene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__ALKYL__45__GLYCERONE__45__3__45__PHOSPHATE" name="1-alkyl-glycerone 3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__Dithiols__124__" name="a protein dithiol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__641" name="mevalonate-5-PP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__341" name="S-succinyl-dihydrolipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SULFATE" name="sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INDOLE_ACETALDEHYDE" name="indole acetaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__841" name="N-acyl-D-mannosamine 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDP__45__CHOLINE" name="CDP-choline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FUM" name="fumarate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SUC__45__COA" name="succinyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CYTIDINE" name="cytidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4211" name="dimethylallyl-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4210" name="trans-zeatin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THR" name="L-threonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SEPO3" name="selenophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THF" name="tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8596" name="&amp;beta;-D-galactosyl-1,4-N-acetyl-&amp;beta;-D-glucosaminylglycopeptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8590" name="O-&amp;beta;-D-xylosylprotein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__N__45__ACETYLNEURAMINYL__45__23__45__ETCETERA" name="&amp;alpha;-N-acetylneuraminyl-2,3-&amp;beta;-D-galactosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9016" name="6,8-dihydroxypurine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALLANTOATE" name="allantoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9017" name="8-hydroxypurine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8595" name="N-acetyl-&amp;beta;-D-glucosaminyl-glycopeptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Alkyl__45__Hydro__45__Peroxides__124__" name="an alkylhydroperoxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GAMMA__45__BUTYROBETAINE" name="&amp;gamma;-butyrobetaine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__ACYLOXYACYL__45__GROUP__45__OF__45__BACTERIAL__45__TOXIN" name="3-(acyloxy)acyl group of bacterial toxin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINOL__45__8" name="ubiquinol-8" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CAMP" name="cyclic-AMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INOSINE" name="inosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4209" name="isopentenyladenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALTOTETRAOSE" name="maltotetraose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ENOL__45__PHENYLPYRUVATE" name="enol-phenylpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYOX" name="glyoxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MYO__45__INOSITOL" name="myo-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NICOTINE" name="nicotine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="O__45__ACETYLCARNITINE" name="(-)O-acetylcarnitine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADP" name="ADP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Histone__45__N__45__o__45__methyl__45__arginines__124__" name="[histone]-N&amp;omega;-methyl-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__Disulfides__124__" name="a protein disulfide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__MANNOSAMINE" name="N-acetyl-D-mannosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEAMIDO__45__NAD" name="nicotinate adenine dinucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALTOTRIOSE" name="maltotriose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" name="2-methyl-3-hydroxybutyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HYPOXANTHINE" name="hypoxanthine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__SEROTONIN" name="N-acetyl-serotonin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__3b__45__hydroxy__45__D5__45__steroids__124__" name="a 3&amp;beta;-hydroxy-&amp;delta;5-steroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N6N6N6__45__TRIMETHYL__45__L__45__LYSINE" name="N6,N6,N6-trimethyl-L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8578" name="histone-L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8579" name="histone N6-methyl-L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__KETOLACTOSE" name="3&apos;-ketolactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DELTA1__45__PIPERIDEINE__45__2__45__CARBOXYLATE" name="&amp;Delta;1-piperideine-2-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__609" name="P1,P4-bis(5&apos;-guanosyl) tetraphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__FORMIMINO__45__L__45__GLUTAMATE" name="N-formimino-L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALONYL__45__COA" name="malonyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__OXO__45__CHOLYL__45__COA" name="3-oxo-cholyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADP__45__SUGARS" name="an ADP-sugar" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ubiquinones__124__" name="a ubiquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__UREIDO__45__PROPIONATE" name="3-ureidopropionate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMINO__45__ACETONE" name="aminoacetone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__607" name="adenosine tetraphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" name="D-glucono-&amp;delta;-lactone-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETOL" name="acetol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALLYSINE" name="2-aminoadipate-6-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_6E8Z11Z14Z__45__5S__45__5__45__HYDROPEROXYCOSA__45__6" name="(6E,8Z,11Z,14Z)-(5s)-5-hydroperoxycosa-6,8,11,14-tetraenoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Galactosyl__45__fucosyl__45__galactosyl__45__R__124__" name="a galactosyl-(1->3)-[&amp;alpha;-L-fucosyl(1->2)]-D-galactosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NN__45__DIMETHYLANILINE" name="N,N-dimethylaniline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_7__45__8__45__DIHYDROPTEROATE" name="7,8-dihydropteroate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANINE" name="guanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8563" name="myosin light-chain phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8564" name="myosin light-chain" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AGMATHINE" name="agmatine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S8" name="S0" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RX" name="RX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HEXAPRENYL__45__4__45__HYDROXY__45__5__45__METHOXYBENZOATE" name="3-hexaprenyl-4-hydroxy-5-methoxybenzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="URATE" name="urate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETO__45__3__45__METHYL__45__VALERATE" name="2-keto-3-methyl-valerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DESMOSTEROL__45__CPD" name="desmosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Sugar__124__" name="a sugar" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Histone__45__L__45__arginines__124__" name="[histone]-L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__GLYCERO__45__PHOSPHORYLCHOLINE" name="L-1-glycero-3-phosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" name="5&apos;-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Thiopurine__45__Methylethers__124__" name="a thiopurine S-methylether" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__formyl__45__D__45__kynurenine" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" name="6-pyruvoyl tetrahydropterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8550" name="a substituted &amp;beta;-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYLNEURAMINATE" name="N-acetylneuraminate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TTP" name="dTTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUTARYL__45__COA" name="glutaryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSYLCERAMIDE__45__SULFATE" name="a cerebroside 3-sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__1__45__Acylglycero__45__Phosphocholines__124__" name="a 1-acyl-2-lyso-glycerophosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__GLC__45__6__45__P" name="&amp;alpha;-D-glucose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OH__45__PYR" name="hydroxypyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Myelin__45__L__45__arginines__124__" name="[myelin basic protein]-L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z13E__45__15S__45__9__45__ALPHA15__45__DIHYDROXY__45__11__45__O" name="(5z,13e)-(15s)-9-&amp;alpha;,15-dihydroxy-11-oxoprosta-5,13-dienoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aryl__45__Sulfate__124__" name="an aromatic sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DOPAQUINONE" name="dopaquinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__GERANYLGERANYL__45__PROTEIN" name="a S-geranylgeranyl protein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HEXAPRENYL__45__45__45__DIHYDROXYBENZOATE" name="3-hexaprenyl-4,5-dihydroxybenzoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XYLULOSE__45__5__45__PHOSPHATE" name="D-xylulose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCEROL" name="glycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" name="5-phosphoribosyl-N-formylglycineamidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8123" name="molybdenum cofactor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__XYLULOSE" name="D-xylulose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8124" name="molybdenum cofactor (sulfide)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETALD" name="acetaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETOACETYL__45__COA" name="acetoacetyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__tyrosine__45__phosphates__124__" name="a protein-L-tyrosine phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FMNH2" name="FMNH2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINE" name="&amp;beta;-D-galactosyl-1,4-N-acetyl-&amp;beta;-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FMN" name="FMN" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8537" name="tRNA pseudouridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIACYLGLYCEROL" name="a 1,2-diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__AMINO__45__LEVULINATE" name="5-amino-levulinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRP" name="L-tryptophan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THYMINE" name="thymine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8538" name="tRNA uridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHIONYL__45__PEPTIDE" name="methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__N__45__ACETYLNEURAMINYL__45__ETCETERA__45__GALACT" name="&amp;alpha;-N-acetylneuraminyl-2,3-&amp;beta;-D-galactosyl-1,3-N-acetyl-&amp;alpha;-D-galactosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINO__45__3__45__3__45__OXOPROP__45__2__45__ENYL__45__BUT__45__2__45__ENEDI" name="2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__5__45__METHOXY__45__TRYPTAMINE" name="melatonin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Serines__124__" name="(L) or (D)-serine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Glycerophosphodiesters__124__" name="a glycerophosphodiester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINO__45__4__45__OXO__45__4__45__ALPHA__45__HYDROXY__45__" name="2-amino-4-oxo-4-&amp;alpha;-hydroxy-6-(erythro-1&apos;,2&apos;,3&apos;-trihydroxypropyl)-5,6, 7,8-tetrahydroxypterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUCONATE" name="D-gluconate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__91__3__45__METHYL__45__2__45__OXOBUTANOATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93____32__PHOSPHATE" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__Tyrosines__124__" name="a protein L-tyrosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PALMITALDEHYDE" name="palmitaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PRPP" name="5-phosphoribosyl 1-pyrophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z13E__45__11__45__ALPHA__45__HYDROXY__45__915__45__DIOXOPROS__45__ENO" name="(5Z,13E)-11-&amp;alpha;-hydroxy-9,15-dioxoprost-13-enoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8528" name="peptidyl 2-hydroxyglycine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C55__45__PP__45__GLCNAC__45__MANNACA__45__FUC4NAC" name="undecaprenyl N-acetyl-glucosaminyl-N-acetyl-mannosaminuronate-4-acetamido-4,6-dideoxy-D-galactose pyrophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMP" name="AMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ETOH" name="ethanol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMATE" name="formate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" name="a 1,4-&amp;alpha;-D-glucan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HEPARIN__45__GLUCOSAMINE__45__3__45__O__45__SULFATE" name="heparin-glucosamine 3-O-sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__FUCOSE" name="L-fucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P3I" name="PPPi" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DTDP__45__D__45__GLUCOSE" name="dTDP-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_13__45__BETA__45__D__45__GALACTOSYL__45__N__45__ACETYL__45__D__45__GLUCO" name="1,3-&amp;beta;-D-galactosyl-N-acetyl-D-glucosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_6__45__ALPHA__45__D__45__GLUCOSAMINYL__45__1D__45__MYO__45__INOSIT" name="6-(&amp;alpha;-D-glucosaminyl)-1D-myo-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9649" name="all-trans-undecaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRU1P" name="fructose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DUTP" name="dUTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PSEUDOURIDINE__45__5__45__P" name="pseudouridine 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXYQUININE" name="3-hydroxyquinine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DPG" name="1,3-diphosphateglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BIOTIN" name="biotin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Plant__45__Ceramides__45__I__124__" name="a plant ceramide (I)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GAMMA__45__LINOLENOYL__45__COA" name="&amp;gamma;-linolenoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Diphospho__45__myo__45__inositol__45__polyphosphates__124__" name="a diphospho-myo-inositol polyphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" name="3-methylglutaconyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__GALACTOSE" name="UDP-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DOLICHOLP" name="dolichyl-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Truncated__45__Limit__45__Dextrins__124__" name="a limit dextrin with short branches" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9610" name="all-trans-decaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LANOSTEROL" name="lanosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC__45__D__45__LACTONE" name="glucono-&amp;delta;-lactone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__MYO__45__INOSITOL__45__4__45__PHOSPHATE" name="D-myo-inositol (4)-monophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" name="N-acetyl-D-glucosamine-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__400" name="guaiacol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__N6N6N6__45__TRIMETHYL__45__L__45__LYSINE" name="3-hydroxy-N6,N6,N6-trimethyl-L-lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__405" name="a phosphatidyl-N-methylethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__409" name="2-monoacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" name="all-trans-hexaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINE" name="S-adenosyl-L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HEPARIN" name="heparin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__N__45__ACETYLNEURAMINYL__45__26__45__BETA__45__D__45__GALA" name="&amp;alpha;-N-acetylneuraminyl-2,6-&amp;beta;-D-galactosyl-1,4-N-acetyl-&amp;beta;-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYINOSINE" name="deoxyinosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BETAINE_ALDEHYDE" name="betaine aldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__GLUCOSE" name="&amp;alpha;-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Alpha__45__D__45__aldose__45__1__45__phosphates__124__" name="an &amp;alpha;-D-aldose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="B__45__ALANINE" name="&amp;beta;-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__971" name="a limit dextrin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADPH" name="NADPH" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HEME_O" name="heme o" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAMINE__45__5P" name="pyridoxamine 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FAD" name="FAD" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__C__45__TERMINAL__45__S__45__ETC__45__CYSTEINE" name="protein c-terminal s-farnesyl-l-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRYPTAMINE" name="tryptamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="EPOXYSQUALENE" name="(S)-2,3-epoxysqualene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__206" name="phytanoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" name="an L-1-phosphatidylglycerol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMINO__45__PARATHION" name="amino-parathion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIETHYLPHOSPHATE" name="diethylphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__PG" name="2-phosphoglycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__6__45__N__45__lipoyl__45__lysine__124__" name="a protein 6-N-(lipoyl)lysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTOHEME" name="protoheme IX" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" name="5-phospho-ribosyl-glycineamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__202" name="cholyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMALDEHYDE" name="formaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__PRENYL__45__L__45__CYSTEINE" name="S-prenyl-L-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8978" name="ethylphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__COA" name="acetyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Dialkyl__45__phosphates__124__" name="a dialkyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HIS" name="L-histidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="COPROPORPHYRINOGEN_III" name="coproporphyrinogen III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__N__45__ACETYLNEURAMINYL__45__28__45__ETCETERA" name="&amp;alpha;-N-acetylneuraminyl-2,8-&amp;alpha;-N-acetylneuraminyl-2,3-&amp;beta;-D-galactosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ACETYLDIHYDROLIPOAMIDE" name="S-acetyldihydrolipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__13__45__ETCETERA" name="N-acetyl-&amp;beta;-D-glucosaminyl-1,3-&amp;beta;-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" name="(S)-1-pyrroline-5-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__17__45__Alpha__45__Hydroxysteroids__124__" name="a 17-&amp;alpha;-hydroxysteroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z13E__45__15S__45__1115__45__DIHYDROXY__45__9__45__OXOPROS" name="(5Z,13E)-(15S)-11,15-dihydroxy-9-oxoprosta-5,13-dienoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8985" name="(+)-(1R,2R)-1,2-diphenylethane-1,2-diol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4702" name="4&amp;alpha;-carboxy-5&amp;alpha;-cholesta-8,24-dien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Diphosphates__124__" name="a ribonucleoside diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1790" name="a maltodextrin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8984" name="cis-stilbene oxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FE__43__3" name="Fe3+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Long__45__Chain__45__Carboxylates__124__" name="a long chain carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FE__43__2" name="Fe2+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHE" name="L-phenylalanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6082" name="3-aminopropionaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UBIQUINOL__45__30" name="ubiquinol-6" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__91__BETA__45__ADRENERGIC__32__RECEPTOR__93__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__trans__45__4__45__cis__45__dienoyl__45__CoAs__124__" name="a 2-trans-4-cis-dienoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__5P" name="D-ribose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SARCOSINE" name="sarcosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NITRIC__45__OXIDE" name="nitric oxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DI__45__H__45__OROTATE" name="dihydroorotate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Triacylglycerols__124__" name="a triacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDRONEOPTERIN__45__P3" name="7,8-dihydroneopterin triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NAD" name="NAD+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__MANNOSE" name="GDP-&amp;alpha;-D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z13E__45__15S__45__11__45__ALPHA15__45__DIHYDROXY__45__9__45__O" name="(5Z,13E)-(15S)-11-&amp;alpha;,15-dihydroxy-9-oxoprosta-5,13-dienoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOPROTEIN__45__ETCETERA__45__GLUCOSAMINYL__45__PHOSP" name="glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCEROL__45__3P" name="sn-glycerol-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TRANS__45__D2__45__ENOYL__45__COA" name="a trans-2-enoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="URACIL" name="uracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z8Z11Z13E__45__15S__45__15__45__HYDROPEROXYICOS" name="(5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="COB__45__I__45__ALAMIN" name="cob(I)alamin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__ISOBUTYRATE" name="3-hydroxy-isobutyrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHONDROITIN" name="chondroitin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Large__45__branched__45__glucans__124__" name="a large-branched glucan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SUC" name="succinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" name="4-imidazolone-5-propionate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HOMO__45__CYS" name="L-homocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__General__45__Phos__45__Protein__45__Substrates__124__" name="a phosphoprotein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THIAMINE" name="thiamin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__248" name="2-formylaminobenzaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z8Z10E14Z__45__12S__45__12__45__HYDROPEROXYICOS" name="(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__16__45__ETCETERA" name="N-acetyl-&amp;beta;-D-glucosaminyl-1,6-&amp;beta;-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__L__45__Amino__45__Acids__124__" name="an L-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DGMP" name="dGMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__40__ADP__45__D__45__RIBOSYL__41____40__N__41____45__ACCEPTOR" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__METHYL__45__MALONYL__45__COA" name="(S)-methyl-malonyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NAD__45__P__45__OR__45__NOP" name="NAD(P)+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aryl__45__Alcohol__124__" name="a phenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__AMINOPENTANOATE" name="5-aminopentanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1109" name="N-acyl-D-mannosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1108" name="1-phosphatidyl-1D-myo-inositol 4-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANIDOACETIC_ACID" name="guanidinoacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Dinucleotide__124__" name="a dinucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Amino__45__Acids__45__20__124__" name="a standard &amp;alpha; amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CITRULLINE" name="citrulline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__239" name="cysteamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1100" name="N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XYLITOL" name="xylitol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALDITOL" name="alditol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INDOLE" name="indole" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__84" name="2,3-diketo-5-methylthio-1-phosphopentane" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__85" name="1,2-dihydroxy-3-keto-5-methylthiopentene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HSCN" name="thiocyanate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RETINOL" name="retinol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1119" name="N-acylneuraminate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acyl__45__Phosphates__124__" name="an acyl phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHONDROITIN__45__4__45__SULFATE" name="chondroitin-4-sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1113" name="6-(&amp;alpha;-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XANTHINE" name="xanthine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BILIRUBIN" name="bilirubin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHYLENE__45__THF" name="5,10-methylene-THF" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BIOPTERIN" name="dihydrobiopterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYLCHOLINE" name="acetylcholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__BETA__45__CHOLESTANE__45__3__45__ALPHA7__45__ALPHA12__45__ALP" name="5-&amp;beta;-cholestane-3&amp;alpha;,7&amp;alpha;,12&amp;alpha;-triol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7188" name="D-galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__1P" name="ribose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__223" name="UDP-L-iduronate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UROCANATE" name="urocanate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH" name="NADH" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CYS" name="L-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AICAR" name="aminoimidazole carboxamide ribonucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSINE" name="adenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Carboxylic__45__esters__124__" name="a carboxylic ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z13E__45__15S__45__91115__45__TRIHYDROXYPROSTA__45__" name="(5Z,13E)-(15S)-9,11,15-trihydroxyprosta-5,13-dienoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADP" name="NADP+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__D__45__Hexoses__124__" name="a D-hexose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LEUKOTRIENE__45__C4" name="leukotriene-C4" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1121" name="D-myo-inositol 1,2-cyclic phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7181" name="N-acetylneuraminyl-2,3-&amp;alpha;-D-galactosyl-1,4-&amp;beta;-D-glucosylceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__THF__45__GLU__45__N" name="an N10-formyl-tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__Glycines__124__" name="a protein glycine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXYACYL__45__GROUP__45__OF__45__BACTERIAL__45__TOXIN" name="3-hydroxyacyl group of bacterial toxin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Protein__45__L__45__Arginines__124__" name="a protein L-arginine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__479" name="2-oxo-4-methylthiobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CYTOLIPIN_H" name="&amp;beta;-D-galactosyl-(1->4)-D-glucosylceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__488" name="&amp;beta;-L-fucose 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HOMO__45__SER" name="homoserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__678" name="selenide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SPHINGOSINE" name="sphingosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_34__45__DIHYDROXYPHENYLACETALDEHYDE" name="3,4-dihydroxyphenylacetaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12__45__ALPHA__45__D" name="N-acetyl-&amp;beta;-D-glucosaminyl-1,2-&amp;alpha;-D-mannosyl-1,3-(R1)-&amp;beta;-D-mannosyl-R2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORYL__45__ETHANOLAMINE" name="phosphoryl-ethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__PHOSPHATIDATE" name="a 1,2-diacyl-sn-glycerol-3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RETINAL" name="retinal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__68" name="1-aminocyclopropane-1-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__690" name="adenosyl-cobyrinate a,c-diamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBULOSE__45__5P" name="D-ribulose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ISOBUTYRYL__45__COA" name="isobutyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__698" name="campest-4-en-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GALACTOSAMINYL__45__POLYPEPTIDE" name="N-acetyl-D-galactosaminyl-polypeptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__694" name="cob(I)yrinate a,c-diamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7598" name="anandamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__499" name="mevalonate-5P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__OCTANOYLCARNITINE" name="L-octanoylcarnitine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="VAL" name="L-valine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GALACTOSAMINYL__45__13__45__D__45__GALACT" name="N-acetyl-galactosaminyl-(1,3)-D-galactosyl-(1,4)-D-galactosyl-(1,4)-D-glucosylceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aliphatic__45__N__45__Acetyl__45__Diamines__124__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__SERINE" name="an L-1-phosphatidylserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__289" name="trans-1,2-Dihydrobenzene-1,2-diol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PUTRESCINE" name="putrescine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CIS__45__DELTA3__45__ENOYL__45__COA" name="a cis-3-enoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PAP" name="adenosine-3&apos;,5&apos;-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HCO3" name="bicarbonate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TDP" name="dTDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__OXOPROLINE" name="5-oxoproline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Purine__45__Bases__124__" name="a purine base" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1027" name="a debranched limit dextrin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="O__45__UREIDOHOMOSERINE" name="O-ureidohomoserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NIACINAMIDE" name="nicotinamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__270" name="N-acyl-D-glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__465" name="presqualene diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHO__45__ENOL__45__PYRUVATE" name="phosphoenolpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DELTA3__45__ISOPENTENYL__45__PP" name="isopentenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OROTIDINE__45__5__45__PHOSPHATE" name="orotidine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__273" name="N-glycoloyl-neuraminate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHOLINE" name="choline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__259" name="4-hydroxyaniline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHENYLETHANOLAMINE" name="phenylethanolamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__671" name="5-formiminotetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__468" name="&amp;alpha;-aminoadipate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROLIPOAMIDE" name="dihydrolipoamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_6__45__LACTOYL__45__5678__45__TETRAHYDROPTERIN" name="6-lactoyl-5,6,7,8-tetrahydropterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TDP__45__FUC4NAC" name="dTDP-4-acetamido-4,6-dideoxy-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Short__45__glucans__124__" name="a short glucan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GERANYL__45__PP" name="geranyl-diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALTOSE" name="maltose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OXALACETIC_ACID" name="oxaloacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__476" name="4-(2-aminophenyl)-2,4-dioxobutanoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GERANYLGERANYL__45__PP" name="all-trans-geranyl-geranyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__METHYL__45__824__45__CHOLESTADIENOL" name="4-&amp;alpha;-methylzymosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_13E__45__11__45__ALPHA__45__HYDROXY__45__915__45__DIOXOPROST__45__1" name="(13E)-11-&amp;alpha;-hydroxy-9,15-dioxoprost-13-enoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__262" name="CMP-N-glycoloylneuraminate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Phosphoserines__124__" name="L(or D)-O-phosphoserine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__266" name="7&amp;alpha;-hydroxycholesterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACET" name="acetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BETAINE" name="glycine betaine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Phytoceramides__124__" name="a phytoceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="C55__45__PP__45__GLCNAC__45__MANNACA" name="undecaprenyl N-acetyl-glucosaminyl-N-acetyl-mannosaminuronate pyrophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DGDP" name="dGDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__DIPHOSPHO__45__1D__45__MYO__45__INOSITOL__45__12346P" name="5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__General__45__Protein__45__Substrates__124__" name="a protein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CROTONYL__45__COA" name="crotonyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INOSITOL__45__1__45__4__45__BISPHOSPHATE" name="D-myo-inositol (1,4)-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__444" name="5-methylthioribose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETO__45__ISOVALERATE" name="2-keto-isovalerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_1__45__ACYL__45__GLYCERONE__45__3__45__PHOSPHATE" name="1-acyl-glycerone 3-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="A__45__LIPID__45__HYDROPEROXIDE" name="a lipid hydroperoxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__L__45__CITRULLINE" name="a protein-L-citrulline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DCDP" name="dCDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FRUCTOSE__45__6P" name="D-fructose-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_17__45__BETA__45__HYDROXY__45__5ALPHA__45__ANDROSTAN__45__3__45__O" name="17-&amp;beta;-hydroxy-5&amp;alpha;-androstan-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXINE" name="pyridoxine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acids__124__" name="an acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__AMINO__45__BUTYRATE" name="4-aminobutyrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ubiquinols__124__" name="a ubiquinol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_6Z8E10E14Z__45__5S12R__45__512__45__DIHYDROXYI" name="(6z,8e,10e,14z)-(5s,12r)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__GLU" name="N-acetyl-L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" name="N-acetyl-glucosamine-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__DESULFOHEPARIN" name="N-desulfoheparin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_20__45__OH__45__LTB4" name="(6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14- tetraenoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__452" name="6-(N-acetyl-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DADP" name="dADP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Glucuronosylated__45__Glucuronoside__45__Acceptors__124__" name="a glucuronosylated glucuronoside acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SPERMIDINE" name="spermidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aliphatic__45__Amines__124__" name="an aliphatic amine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__415" name="acylglycerone phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALKYL__45__SULFATE" name="alkyl sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D2__45__ENOYL__45__COA" name="a 2,3-dehydroacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__419" name="L-Palmitoylcarnitine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1063" name="2-O-(6-phospho-&amp;alpha;-mannosyl)-D-glycerate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GALACTOSYL__45__14__45__D__45__GALACTOSYL__45__14__45__D__45__" name="&amp;alpha;-D-galactosyl-(1->4)-&amp;beta;-D-galactosyl-(1->4)-D-glucosylceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" name="L-erythro-4-hydroxy-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z13E__45__15S__45__11__45__ALPHA15__45__DIHYDROXY__45__9__45__O__45__ENOAT" name="(5Z,13E)-(15S)-11-&amp;alpha;,15-dihydroxy-9-oxoprost-13-enoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__40__ADP__45__D__45__RIBOSYL__41____40__N__43__1__41____45__ACCEPTOR" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DOPAMINE" name="dopamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="URIDINE" name="uridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__426" name="N-acylglycine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HCN" name="hydrogen cyanide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRUVATE" name="pyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HCL" name="HCl" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__1__45__Alkyl__45__sn__45__glycero__45__3__45__phosphocholines__124__" name="a 1-alkyl-sn-glycero-3-phosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_6__45__26__45__BISN__45__ACETYL__45__ETCETERA__45__MANNOSYL__45__R" name="6-(2,6-bis[N-acetyl-&amp;beta;-D-glucosaminyl]-&amp;alpha;-D-mannosyl)-&amp;beta;-D-mannosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4081" name="4&amp;alpha;-methylfecosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEHYDROSPHINGANINE" name="3-dehydrosphinganine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALTOHEXAOSE" name="maltohexaose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N1__45__ACETYLSPERMINE" name="N1-acetylspermine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7100" name="2-isopropyl-3-oxosuccinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__FORMYL__45__THF" name="5-formyl-tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__18" name="linoleoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__S__45__2__45__Hydroxyacids1__124__" name="an (S)-2-hydroxyacid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ESTRONE" name="estrone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LEU" name="L-leucine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__N__45__Acylated__45__Amino__45__Acids__124__" name="an N-acyl-L-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GLUTAMATE__45__5__45__P" name="L-glutamate-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ORNITHINE" name="L-ornithine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARNITINE" name="L-carnitine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__ACETYL__45__D__45__MANNOSAMINE__45__6P" name="N-acetyl-D-mannosamine-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__GLUCOSAMINE__45__6__45__P" name="D-glucosamine-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Cyclic__45__3__45__5__45__Ribonucleoside__45__Monophosphates__124__" name="a nucleoside 3&apos;,5&apos;-cyclic phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" name="L-glutamate &amp;gamma;-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Purine__45__Ribonucleosides__124__" name="a purine ribonucleoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ENZYME__45__S__45__SULFANYLCYSTEINE" name="a protein-S-sulfanylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Nucleoside__45__Diphosphates__124__" name="a nucleoside diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OLEOYL__45__COA" name="oleoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANOSINE_DIPHOSPHATE_FUCOSE" name="GDP-L-fucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Glucosyl__45__Ceramides__124__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NUCLEOSIDE__45__PHOSPHATE" name="a nucleoside phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" name="5&apos;-phosphoribosyl-N-formylglycineamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4580" name="4&amp;alpha;-formyl-5&amp;alpha;-cholesta-8,24-dien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROPANE__45__1__45__2__45__DIOL" name="L-1,2-propanediol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1093" name="1-deoxy-D-xylulose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__1091" name="S-ureidoglycolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CYTOSINE" name="cytosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Steroids__124__" name="a steroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4581" name="5&amp;alpha;-cholesta-8,24-dien-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__91__PYRUVATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93__" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CANALINE" name="L-canaline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" name="5-phospho-&amp;beta;-D-ribosyl-amine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__511" name="pantetheine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PARATHION" name="parathion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__epoxides__124__" name="an epoxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOSYL__45__N__45__ACYLSPHINGOSINE" name="glycosyl-N-acylsphingosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINO__45__ETCETERA__45__TRIPHOSPHATE" name="2-amino-4-oxo-6-(erythro-1&apos;,2&apos;,3&apos;-trihydroxyprolyl)-7,8-dihydroxypteridine triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__BETA__45__CHOLESTANE__45__3__45__ALPHA7__45__TETRAOL" name="5&amp;beta;-cholestane-3&amp;alpha;,7&amp;alpha;,12&amp;alpha;,26-tetraol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__Acylglycero__45__Phosphocholines__124__" name="a 1-lyso-2-acyl-sn-glycero-3-phosphocholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__6321" name="procollagen trans 4-hyroxy-L-proline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__709" name="(5&amp;alpha;)-campestan-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIMETHYLAMINE" name="dimethylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OCTAPRENYL__45__DIPHOSPHATE" name="all-trans-octaprenyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4579" name="4&amp;alpha;-hydroxymethyl-5&amp;alpha;-cholesta-8,24-dien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CDP" name="CDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4578" name="3-keto-4-methylzymosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4577" name="4&amp;alpha;-carboxy-4&amp;beta;-methyl-5&amp;alpha;-cholesta-8,24-dien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__505" name="D-myo-inositol (1,3,4,6)-tetrakisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__506" name="D-myo-inositol (1,3,4,5)-tetrakisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4576" name="4&amp;alpha;-formyl-4&amp;beta;-methyl-5&amp;alpha;-cholesta-8,24-dien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4575" name="4&amp;alpha;-hydroxymethyl-4&amp;beta;-methyl-5&amp;alpha;-cholesta-8,24-dien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA" name="(4&amp;alpha;)-methyl-(5&amp;alpha;)-ergosta-8,14,24(28)-trien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4573" name="4,4-dimethyl-14&amp;alpha;-formyl-5&amp;alpha;-cholesta-8,24-dien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__4__45__DEHYDRO__45__6__45__L__45__DEOXYGALACTOSE" name="GDP-4-dehydro-6-L-deoxygalactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__502" name="ceramide 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__504" name="1-monoacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12" name="N4-{N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,3)-[N-acetyl-&amp;beta;-D-glucosaminyl-(1,2)-&amp;alpha;-D-mannosyl-(1,6)]-&amp;beta;-D-mannosyl-(1,4)-N-acetyl-&amp;beta;-D-glucosaminyl-(1,4)-N-acetyl-&amp;beta;-D-glucosaminyl}asparagine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="KERATAN__45__6__45__SULFATE" name="keratan 6&apos;-sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROSTAGLANDIN__45__H2" name="prostaglandin-H2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHYL__45__MALONYL__45__COA" name="(R)-methylmalonyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CANAVANINOSUCCINATE" name="canavaninosuccinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GTP" name="GTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__L__45__KYNURENINE" name="3-hydroxy-L-kynurenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aldehydes__124__" name="an aldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DI__45__H__45__URACIL" name="dihydrouracil" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETO__45__GLUTARAMATE" name="2-keto-glutaramate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__4568" name="4,4-dimethyl-14&amp;alpha;-hydroxymethyl-5&amp;alpha;-cholesta-8,24-dien-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="R__45__2__45__METHYLACYL__45__COA" name="(2R)-2-methylacyl-coa" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aryl__45__sulfates__124__" name="an aryl sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHLORDECONE__45__ALCOHOL" name="chlordecone alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MANNOSE__45__6P" name="D-mannose-6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCYL__45__PEPTIDE" name="glycyl-peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__3__45__HYDROXYACYL__45__COA" name="an (R)-3-hydroxyacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__ALANINE" name="D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__KETOACYL__45__COA" name="3-oxoacyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__GLUCOSE" name="UDP-D-glucose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Starch__124__" name="starch" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORYL__45__CHOLINE" name="phosphoryl-choline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HEPARIN__45__GLUCOSAMINE" name="heparin glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__METHYLTHIOADENOSINE" name="S-methyl-5&apos;-thioadenosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P__45__HYDROXY__45__PHENYLPYRUVATE" name="4-hydroxyphenylpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__P__45__SERINE" name="3-phospho-serine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PRENAL" name="3-methyl-2-butenal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_13__45__BETA__45__D__45__GALACTOSYL__45__14__45__ALPHA__45__L__45__FU" name="1,3-&amp;beta;-D-galactosyl-(&amp;alpha;-1,4-L-fucosyl)-N-acetyl-D-glucosaminyl- R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__glycols__124__" name="a glycol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__DEHYDRO__45__ASCORBATE" name="L-dehydro-ascorbate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3183" name="nicotine isomethonium ion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__PIPECOLATE" name="L-pipecolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHYTOSPINGOSINE" name="4-hydroxysphinganine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE" name="D-ribose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" name="GDP-4-dehydro-6-deoxy-D-mannose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FARNESYL__45__PP" name="all-trans-farnesyl diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Phenyl__45__Acetates__124__" name="a phenyl acetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINO__45__4__45__OXO__45__6__45__123__45__TRIHYDROXYPROP" name="2-amino-4-oxo-6-(1&apos;,2&apos;,3&apos;-trihydroxypropyl)-diquinoid-7,8-dihydroxypterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3481" name="bupropion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3483" name="hydroxybupropion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UMP" name="UMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3188" name="N&apos;-hydroxymethyl-norcotinine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL__45__" name="&amp;beta;-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROPIONYL__45__COA" name="propionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_10__45__FORMYL__45__THF" name="10-formyl-tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DCMP" name="dCMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3187" name="2&apos;-hydroxynicotine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3186" name="nicotine-&amp;Delta;1&apos;5&apos;-iminium ion" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__P__45__PANTOTHENATE" name="D-4&apos;-phosphopantothenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Diacylglycerides__124__" name="a diacylglycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" name="5-aminoimidazole ribonucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__HYDROXY__45__TRYPTOPHAN" name="5-hydroxy-L-tryptophan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PAPS" name="phosphoadenosine-5&apos;-phosphosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="OBTUSIFOLIOL" name="obtusifoliol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__SULFINOALANINE" name="3-sulfinoalanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SER" name="L-serine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHYL__45__GLYOXAL" name="methylglyoxal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Myo__45__inositol__45__polyphosphates__124__" name="a myo-inositol-polyphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleosides__124__" name="a ribonucleoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__3__45__Oxo__45__Delta__45__4__45__Steroids__124__" name="a 3-oxo-&amp;delta;4-steroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__HEXAPRENYL__45__3__45__METHYL__45__5__45__HYDROXY__45__6__45__METHOX" name="2-hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHACRYLYL__45__COA" name="methylacrylyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THIAMINE__45__PYROPHOSPHATE" name="thiamine diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CIS__45__ACONITATE" name="cis-aconitate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="A__45__GALACTOSYLCERAMIDE" name="a cerebroside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__L__45__BETA__45__ISOASPARTATES" name="a protein L-&amp;beta;-isoaspartate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CH3__45__MALONATE__45__S__45__ALD" name="methylmalonate-semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aryl__45__Amines__124__" name="an arylamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__N__45__DIACETYLNEURAMINYL__45__23__45__BETA__45__D__45__ETC" name="&amp;alpha;-N-acetylneuraminyl-(2->3)-&amp;beta;-D-galactose-(1->3)-(&amp;alpha;-N-acetylneuraminyl-(2->6))-N-acetyl-D-galactosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CARBOXYMETHYL__45__HYDROXYPHENYLPROPCOA" name="2-carboxymethyl-3-hydroxyphenylpropionyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TREHALOSE" name="trehalose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__a__45__long__45__chain__45__alcohol__124__" name="a long-chain alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" name="a 5-L-glutamyl-L-amino acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CREATINE" name="creatine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9569" name="L-sorbose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUCOSAMINE" name="glucosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TIGLYL__45__COA" name="tiglyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD0__45__1108" name="&amp;beta;-D-ribofuranose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALTOOLIGOSYLTREHALOSE" name="maltooligosyl-trehalose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__HEXOSE__45__6__45__PHOSPHATE" name="D-hexose 6-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__AMINO__45__BUTYRALDEHYDE" name="4-aminobutanal" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CIT" name="citrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUTATHIONE" name="glutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GALACTOSE__45__1P" name="&amp;alpha;-D-galactose 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8851" name="dopamine quinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NICOTINATE_NUCLEOTIDE" name="nicotinate mononucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="N__45__METHYL__45__HISTAMINE" name="N&amp;tau;-methylhistamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROTEIN__45__C__45__TERMINAL__45__S__45__FARNESYL__45__L__45__CYSTEINE" name="protein c-terminal s-farnesyl-l-cysteine methyl ester" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__16__45__N__45__ACETYL__45__D" name="&amp;beta;-D-galactosyl-1,3-(N-acetyl-&amp;beta;-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__10156" name="a N-acetyl-D-glucosaminyl-polyepetide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S2O3" name="thiosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_4__45__FUMARYL__45__ACETOACETATE" name="4-fumaryl-acetoacetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2R__45__HYDROPEROXY__45__FATTY__45__ACIDS" name="a 2(R)-hydroperoxy fatty acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSINE_DIPHOSPHATE_RIBOSE" name="ADP-ribose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Deoxynucleotides__124__" name="a deoxynucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXY__45__RIBOSE__45__5P" name="deoxyribose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__N__45__ACETYLNEURAMINYL__45__23__45__BETA__45__ETCETER" name="&amp;alpha;-N-acetylneuraminyl-2,3-&amp;beta;-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ISOVALERYL__45__COA" name="isovaleryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acylcholines__124__" name="an acylcholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LINOLENIC_ACID" name="&amp;alpha;-linolenate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD1F__45__129" name="&amp;beta;-carotene" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_14__45__BETA__45__D__45__XYLANS" name="a 1,4-&amp;beta;-D-xylan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7649" name="dopamine 3-O-sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__LACTOYL__45__GLUTATHIONE" name="S-lactoyl-glutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ANDROSTERONE" name="androsterone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2K__45__4CH3__45__PENTANOATE" name="2-ketoisocaproate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="A__45__3__45__OXO__45__ACID" name="a 3-oxo acid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL" name="&amp;alpha;-D-galactosyl-(1,3)-&amp;beta;-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="E__45__PHENYLITACONYL__45__COA" name="E-phenylitaconyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__11__45__Oxosteroids__124__" name="an 11-oxosteroid" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" name="a glucosylated glycogenin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETOGLUTARATE" name="2-ketoglutarate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8649" name="a protein L-allysine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8646" name="7-dehydrodesmosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Ribonucleoside__45__Triphosphates__124__" name="a ribonucleoside triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__METHYL__45__CROTONYL__45__COA" name="3-methylcrotonyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PALMITYL__45__COA" name="palmitoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__24__45__DINITROPHENYLGLUTATHIONE" name="2,4-dinitrophenyl-S-glutathione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7650" name="3-methoxytyramine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8670" name="portulacaxanthin II" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8671" name="dopaxanthin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8672" name="dopaxanthin quinone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Cyclic__45__2__45__3__45__Ribonucleoside__45__Monophosphates__124__" name="a nucleoside 2&apos;,3&apos;-cyclic phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="A__45__METHYLATED__45__AMINE" name="a methylated amine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GMP" name="GMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UDP__45__D__45__XYLOSE" name="UDP-D-xylose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Aldehydes__45__Or__45__Ketones__124__" name="an aldehyde or ketone" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SUCC__45__S__45__ALD" name="succinate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MELIBIOSE" name="melibiose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" name="3-hydroxy-3-methyl-glutaryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOFLAVIN" name="riboflavin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CGMP" name="cyclic-GMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ANTHRANILATE" name="anthranilate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLC__45__1__45__P" name="&amp;alpha;-D-glucose 1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYLNEURAMINYL__45__23__45__BETA__45__D__45__GALACTOSYL__45__ET" name="&amp;alpha;-N-acetylneuraminyl-2,3-&amp;beta;-D-galactosyl-1,4-N-acetyl-&amp;beta;-D-glucosaminyl-1,3-&amp;beta;-D-galactosyl-1,4-D-glucosylceramide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" name="D-myo-inositol (1,4,5,6)-tetrakisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="XANTHOSINE__45__5__45__PHOSPHATE" name="xanthosine-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLUCOSAMINYL__45__14__45__ETCETERA__45__MANNOSYL__45__R" name="N-acetyl-&amp;beta;-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-&amp;alpha;-D-mannosyl-1,3-(&amp;beta;-N-acetyl-D-glucosaminyl-1,2-&amp;alpha;-D-mannosyl-1,6)-&amp;beta;-D-mannosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Sterols__124__" name="a sterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GUANOSINE" name="guanosine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLY" name="glycine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BUTYRIC_ACID" name="butyrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CMP" name="CMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLN" name="L-glutamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Glycogens__124__" name="a glycogen" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLT" name="L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5Z13E__45__15S__45__69__45__ALPHA__45__EPOXY__45__11__45__ALPHA" name="(5z,13e)-(15s)-6,9-&amp;alpha;-epoxy-11-&amp;alpha;,15-dihydroxyprosta-5,13-dienoate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ASCORBATE" name="L-ascorbate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CREATINE__45__P" name="creatine-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ALPHA__45__ALANINE" name="L-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8202" name="4-&amp;beta;-D-galactosyl-O-&amp;beta;-D-xylosylprotein" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOCHOLIC_ACID" name="glycocholate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CATECHOL" name="catechol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UTP" name="UTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Alditols__124__" name="an alditol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THYMIDINE" name="thymidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8611" name="4&amp;alpha;-hydroxymethyl-4&amp;beta;-methyl-5&amp;alpha;-cholesta-8-en-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2751" name="5&apos;-hydroxycotinine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8612" name="4&amp;alpha;-formyl-4&amp;beta;-methyl-5&amp;alpha;-cholesta-8-en-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2750" name="trans-3&apos;-hydroxycotinine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXY__45__RIBOSE__45__1P" name="deoxyribose-1-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8613" name="4&amp;alpha;-carboxy-4&amp;beta;-methyl-5&amp;alpha;-cholesta-8-en-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8614" name="4&amp;alpha;-methyl-5&amp;alpha;-cholesta-8-en-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8892" name="leukotriene-A4" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" name="3-hydroxy-isobutyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8610" name="4,4-dimethyl-5&amp;alpha;-cholesta-8-en-3-&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8619" name="4&amp;alpha;-carboxy-5&amp;alpha;-cholesta-8-en-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__5881" name="4&amp;alpha;-hydroxy-tetrahydrobiopterin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PRO" name="L-proline" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Beta__45__D__45__Glucuronides__124__" name="a &amp;beta;-D-glucuronoside" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8617" name="4&amp;alpha;-hydroxymethyl-5&amp;alpha;-cholesta-8-en-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8618" name="4&amp;alpha;-formyl-5&amp;alpha;-cholesta-8-en-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYCYTIDINE" name="deoxycytidine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__91__PYRUVATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93____32__PHOSPHATE" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FADH2" name="FADH2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" name="2-aceto-2-hydroxy-butyrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_67__45__DIHYDROPTERIDINE" name="6,7-dihydropteridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PANTETHEINE__45__P" name="4&apos;-phosphopantetheine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" name="pyrroline-hydroxy-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYXYLULOSE__45__5P" name="1-deoxy-D-xylulose 5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8602" name="[3-methylcrotonoyl-CoA:carbon-dioxide ligase(ADP-forming)]" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8603" name="&amp;alpha;-N-acetyl-D-glucosaminyl-(1->4)-&amp;beta;-D-glucuronosyl-(1->3)-&amp;beta;-D-galactosyl-(1->3)-&amp;beta;-D-galactosyl-(1->4)-&amp;beta;-D-xylosylproteoglycan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__3604" name="N-acetyl-D-galactosamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8601" name="APO-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CO__45__A" name="coenzyme A" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="LIPOYL__45__AMP" name="lipoyl-AMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IODINE__45__MOLECULE" name="I2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__7682" name="(S)-2,3,4,5-tetrahydropiperidine-2-carboxylate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="BUTYRYL__45__COA" name="butyryl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8608" name="4,4-dimethyl-14&amp;alpha;-formyl-5&amp;alpha;-cholesta-8-en-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CTP" name="CTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__2__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" name="a nucleoside 2&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8609" name="4,4-dimethyl-5-&amp;alpha;-cholesta-8,14-dien-3-&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2747" name="cotinine-glucuronide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8606" name="24,25-dihydrolanosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2742" name="cotinine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8607" name="4,4-dimethyl-14&amp;alpha;-hydroxymethyl-5&amp;alpha;-cholesta-8-en-3&amp;beta;-ol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__All__45__Amines__124__" name="an amine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHATIDYLCHOLINE" name="a phosphatidylcholine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THF__45__GLU__45__N" name="a tetrahydrofolate polyglutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2744" name="nicotine-Glucuronide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__2743" name="nicotine-1&apos;-N-oxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="MALTOPENTAOSE" name="maltopentaose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DGTP" name="dGTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINOMUCONATE_SEMIALDEHYDE" name="2-aminomuconate semialdehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SORBITOL" name="D-sorbitol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENINE" name="adenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HOMOGENTISATE" name="homogentisate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_6__45__2__45__N__45__ACETYL__45__ETCETERA__45__MANNOSYL__45__R" name="6-(2-[N-acetyl-&amp;beta;-D-glucosaminyl]-&amp;alpha;-D-mannosyl)-&amp;beta;-D-mannosyl-R" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Primary__45__Alcohols__124__" name="a primary alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_3__45__P__45__HYDROXYPYRUVATE" name="3-phospho-hydroxypyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" name="4,4-dimethylzymosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ZYMOSTEROL" name="zymosterol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__KYNURENINE" name="kynurenine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Long__45__linear__45__glucans__124__" name="a long-linear glucan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8630" name="(5&apos;)ppPur-mRNA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8631" name="G(5&apos;)ppPur-mRNA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SO3" name="sulfite" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NN__45__DIMETHYLANILINE__45__N__45__OXIDE" name="nn-dimethylaniline-n-oxide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" name="1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Alcohols__124__" name="an alcohol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__10__45__METHENYL__45__THF" name="5,10-methenyltetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="TETRADECANOYL__45__COA" name="myristoyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UREA" name="urea" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CHONDROITIN__45__6__45__SULFATE" name="chondroitin-6-sulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" name="an L-1-phosphatidyl-glycerol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DATP" name="dATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__91__BETA__45__ADRENERGIC__32__RECEPTOR__93____32__PHOSPHATE" name="NA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8620" name="5&amp;alpha;-cholesta-8-en-3-one" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8621" name="zymostenol" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8624" name="peptidylproline (&amp;omega; = 180)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__AMINO__45__ETCETERA__45__DIHYDROXYPTERIDINE" name="2-amino-4-oxo-6-(1&apos;,2&apos;-dioxoprolyl)-7,8-dihydroxypteridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8625" name="peptidylproline (&amp;omega; = 0)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DCTP" name="dCTP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__8622" name="&amp;beta;-D-glucuronosyl-(1->3)-&amp;beta;-D-galactosyl-(1->3)-&amp;beta;-D-galactosyl-(1->4)-&amp;beta;-D-xylosyl-proteoglycan" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DEOXYNUCLEOTIDESM" name="(deoxynucleotides)(m)" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLYCOPROTEIN__45__ETCETERA__45__GALACTOSE" name="a glycoprotein-&amp;alpha;-L-fucosyl-(1,2)-D-galactose" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
</listOfSpecies>
<listOfReactions>
  <reaction id="ATP__45__CITRATE__45__PRO__45__S__45____45__LYASE__45__RXN" name="ATP-citrate (pro-S-)-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACLY )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP-citrate (pro-S-)-lyase )</html:p>
<html:p>SUBSYSTEM: superpathway of acetyl-CoA biosynthesis</html:p>
<html:p>SUBSYSTEM: acetyl-CoA biosynthesis (from citrate)</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: OXALACETIC_ACID</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AKBLIG__45__RXN" name="Glycine C-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GCAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: threonine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.29</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GST__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( GSTM3 ) or ( GSTM2 ) or ( GSTM4 ) or ( GSTA4 ) or ( GSTM1 ) or ( GSTM5 ) or ( GSTP1 ) or ( LOC51064 ) or ( GSTA3 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione S-transferase ) or ( glutathione S-transferase mu 3 ) or ( glutathione A-transferase mu 2 ) or ( glutathione S-transferase mu 4 ) or ( glutathione S-transferase A4-4 ) or ( glutathione S-transferase mu 1 ) or ( glutathione S-transferase mu 5 ) or ( glutathione S-transferase P ) or ( glutathione S-transferase, mitochondrial ) or ( glutathione S-transferase A3-3 ) or ( glutathione S-transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__CHLORO__45__24__45__DINITROBENZENE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCL" stoichiometry="1"/>
      <speciesReference species="S__45__24__45__DINITROPHENYLGLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__45__PHOSPHATIDYLINOSITOL__45__KINASE__45__RXN" name="1-phosphatidylinositol 4-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PI4KII ) or ( PI4K2B ) or ( PIK4CA ) or ( PIK4CB ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 4-kinase type II ) or ( phosphatidylinositol 4-kinase type-II beta ) or ( phosphatidylinositol 4-kinase, catalytic, alpha polypeptide isoform 1 ) or ( phosphatidylinositol 4-kinase, catalytic, beta polypeptide ) or ( phosphatidylinositol 4 kinase alpha )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.67</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDHDEHYDROG__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH3B1 ) or ( ALDH3A2 ) or ( ALDH9A1 ) or ( ALDH1A1 ) or ( ALDH3B2 ) or ( NA ) or ( ALDH7A1 ) or ( ALDH1A3 ) or ( ALDH8A1 ) or ( MGC10204 ) or ( ALDH1B1 ) or ( NA ) or ( ALDH3A1 ) or ( ALDH1A2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 7 ) or ( fatty aldehyde dehydrogenase ) or ( aldehyde dehydrogenase, E3 isozyme ) or ( aldehyde dehydrogenase 1A1 ) or ( aldehyde dehydrogenase 8 ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase family 7 member A1 ) or ( aldehyde dehydrogenase 1A3 ) or ( aldehyde dehydrogenase 8A1 isoform 1 ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase x, mitochondrial precursor ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase, dimeric NADP-preferring ) or ( aldehyde dehydrogenase 1A2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R15__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine aminotransferase )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.5</html:p>
<html:p>SIDE: __124__Keto__45__Acid__124__</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="__124__Keto__45__Acid__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLPYRUVATE__45__TAUTOMERASE__45__RXN" name="Phenylpyruvate tautomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MIF ) or ( DDT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( macrophage migration inhibitory factor ) or ( D-DOPACHROME TAUTOMERASE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ENOL__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENETHFDEHYDROG__45__NADP__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( MTHFD1 ) or ( NA ) or ( DKFZP586G1517 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C1 tetrahydrofolate synthase cytoplasmic C1 THF synthase ) or ( C-1-tetrahydrofolate synthase, cytoplasmic ) or ( C1 tetrahydrofolate synthase cytoplasmic C1 THF synthase ) or ( C1 tetrahydrofolate synthase cytoplasmic C1 THF synthase )</html:p>
<html:p>SUBSYSTEM: reductive acetyl coenzyme A pathway</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__NH3__45__RXN" name="GMP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GMPS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GMP synthase (glutamine-hydrolyzing) )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLGLUCOSAMINE__45__KINASE__45__RXN" name="N-acetylglucosamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NAGK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.59</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRODISULFREDUCT__45__RXN" name="Protein-disulfide reductase (glutathione)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GLRX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( oxidized glutaredoxin )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.4.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOSINE__45__DEHYDROGENASE__45__RXN" name="Sarcosine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SARDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sarcosine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>SUBSYSTEM: creatinine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYL__45__SULFOTRANSFERASE__45__RXN" name="Aryl sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SULT1A2 ) or ( SULT1A3 ) or ( SULT1A3 ) or ( SULT1A3 ) or ( SULT1A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenol-sulfating phenol sulfotransferase 2 ) or ( monoamine-sulfating phenol sulfotransferase ) or ( monoamine-sulfating phenol sulfotransferase ) or ( monoamine-sulfating phenol sulfotransferase ) or ( phenol-sulfating phenol sulfotransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.1</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__sulfates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__17__45__RXN" name="Bis(5&apos;-nucleosyl)-tetraphosphatase (asymmetrical)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NUDT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bis(5&apos;-nucleosyl)-tetraphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLESTANETRIOL__45__26__45__MONOOXYGENASE__45__RXN" name="Cholestanetriol 26-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP27A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 27, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.15</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__BETA__45__CHOLESTANE__45__3__45__ALPHA7__45__ALPHA12__45__ALP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__BETA__45__CHOLESTANE__45__3__45__ALPHA7__45__TETRAOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__9__45__RXN" name="Saccharopine dehydrogenase (NAD+, L-glutamate forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AASS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysine-ketoglutarate reductase /saccharopine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__198__45__RXN" name="Phosphatidylinositol N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PIGH ) or ( PIGC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol-glycan biosynthesis, class H protein ) or ( phosphatidylinositol-glycan biosynthesis, class C protein )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.198</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__452" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__9__45__RXN" name="Lactosylceramide &amp;alpha;-2,3-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SIAT9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lactosylceramide alpha-2,3-sialyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.9</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTOLIPIN_H" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7181" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKYLGLYCERONE__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="Alkylglycerone-phosphate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AGPS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alkyldihydroxyacetonephosphate synthase, peroxisomal precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.26</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__a__45__long__45__chain__45__alcohol__124__" stoichiometry="1"/>
      <speciesReference species="_1__45__ACYL__45__GLYCERONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Long__45__Chain__45__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="_1__45__ALKYL__45__GLYCERONE__45__3__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__LYSINE__45__6__45__OXIDASE__45__RXN" name="Protein-lysine 6-oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LOXL1 ) or ( LOX ) or ( LOXL3 ) or ( LOXL4 ) or ( LOXL2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysyl oxidase homolog 1 precursor ) or ( protein-lysine 6-oxidase precursor ) or ( lysyl oxidase homolog 3 precursor ) or ( lysyl oxidase homolog 4 precursor ) or ( lysyl oxidase homolog 2 precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__L__45__lysine__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__969" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HAO1 ) or ( HAO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacid oxidase 1 ) or ( hydroxyacid oxidase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__50__45__RXN" name="3-&amp;alpha;-hydroxysteroid dehydrogenase (B-specific)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1C4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1 member C4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.50</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ANDROSTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__342" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__151__45__RXN" name="N-acetyllactosaminide &amp;alpha;-1,3-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( GTA ) or ( CDC2L2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetyllactosaminide alpha-1,3-galactosyltransferase ) or ( galactosyltransferase activator ) or ( galactosyltransferase associated protein kinase p58/GTA )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.87</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROCANATE__45__HYDRATASE__45__RXN" name="Urocanate hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ31300 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( probable urocanate hydratase )</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.49</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROCANATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__11__46__1__46__12__45__RXN" name="Phospholipid-hydroperoxide glutathione peroxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPX4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipid hydroperoxide glutathione peroxidase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.12</html:p>
<html:p>SIDE: LIPID</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: A__45__LIPID__45__HYDROPEROXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__LIPID__45__HYDROPEROXIDE" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="LIPID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__3__45__PHOSPHATE__45__DEHYDROGENASE__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( GPD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol 3 phosphate dehydrogenase mitochondrial precursor ) or ( glycerol-3-phosphate dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FMN_TO_FMNH2_COF_RXN" name="FMN_TO_FMNH2_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FMNH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROID__45__DELTA__45__ISOMERASE__45__RXN" name="Steroid &amp;delta;-isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD3B2 ) or ( NA ) or ( HSD3B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II ) or ( 3-beta-hydroxysteroid dehydrogenase/delta 5 >4 isomerase 3beta HSD ) or ( 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type i )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__oxo__45__D5__45__steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Oxo__45__Delta__45__4__45__Steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__56__45__RXN" name="Methylumbelliferyl-acetate deacetylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ESD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( esterase D )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__181" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__182" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADPSUGPPHOSPHAT__45__RXN" name="ADP-sugar diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NUDT5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-sugar pyrophosphatase ysa1h )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.21</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADP__45__SUGARS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alpha__45__D__45__aldose__45__1__45__phosphates__124__" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__NITROPHENYLPHOSPHATASE__45__RXN" name="4-nitrophenylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NIPSNAP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NIPSNAP homolog 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.41</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__194" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__GALACTOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-GALACTOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLN_TO_GLT_COF_RXN" name="GLN_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__46__3__46__4__46__11__45__RXN" name="Biotin--[methylcrotonoyl-CoA-carboxylase] ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HLCS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotin--protein ligase//biotin--(methylmalonyl-CoA-carboxyltransferase//ligase//biotin--(propionyl-CoA-carboxylase (ATP-hydrolyzing//ligase//biotin--(methylcrotonoyl-CoA-carboxylase//ligase//biotin--(acetyl-CoA-carboxylase//ligase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.11</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8601" stoichiometry="1"/>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAICARSYN__45__RXN" name="Phosphoribosylaminoimidazole-succinocarboxamide synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAICS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional protein ADE2 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__41__45__RXN" name="Polypeptide N-acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GALNT7 ) or ( LOC168391 ) or ( GalNac-T10 ) or ( GALNT1 ) or ( GALNT8 ) or ( GALNT5 ) or ( NA ) or ( GALNT7 ) or ( GALNT12 ) or ( NA ) or ( GALNT4 ) or ( GALNT6 ) or ( NA ) or ( GALNT13 ) or ( GALNT9 ) or ( GALNT3 ) or ( GALNT2 ) or ( WBSCR17 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 ) or ( polypeptide N-acetylgalactosaminyltransferase ) or ( UDP-galnac:polypeptide N-acetylgalactosaminyltransferase t10 ) or ( polypeptide N-acetylgalactosaminyltransferase ) or ( polypeptide N-acetylgalactosaminyltransferase 8 ) or ( galnac-T5 (fragment) ) or ( polypeptide N-acetylgalactosaminyltransferase ) or ( polypeptide N-acetylgalactosaminyltransferase 7 ) or ( polypeptide N-acetylgalactosaminyltransferase ) or ( polypeptide N-acetylgalactosaminyltransferase ) or ( polypeptide N-acetylgalactosaminyltransferase 4 ) or ( polypeptide N-acetylgalactosaminyltransferase 6 ) or ( polypeptide N-acetylgalactosaminyltransferase ) or ( UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 ) or ( polypeptide N-acetylgalactosaminyltransferase 9 ) or ( polypeptide N-acetylgalactosaminyltransferase 3 ) or ( polypeptide N-acetylgalactosaminyltransferase 2 ) or ( Williams Beuren syndrome chromosome region 17 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.41</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLYPEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINYL__45__POLYPEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMYLOMALT__45__RXN" name="4-&amp;alpha;-glucanotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AGL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen debranching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.25</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOTRIOSE" stoichiometry="1"/>
      <speciesReference species="MALTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIMETHYLLYSINE__45__DIOXYGENASE__45__RXN" name="Trimethyllysine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TMLHE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trimethyllysine dioxygenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.8</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N6N6N6__45__TRIMETHYL__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__N6N6N6__45__TRIMETHYL__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDP_TO_GDP__45__MANNOSE_COF_RXN" name="GDP_TO_GDP-MANNOSE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__88__45__RXN" name="Globoside &amp;alpha;-N-acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( forssman synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.88</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINYL__45__13__45__D__45__GALACT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORSSMAN__45__HAPTEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__4281" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1B10 ) or ( AKR1B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 ) or ( aldose reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__HEXAPRENYLTRANSTRANSFERASE__45__RXN" name="all-trans-heptaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.30</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URPHOS__45__RXN" name="Uridine phosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UP ) or ( LOC151531 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine phosphorylase ) or ( liver-specific uridine phosphorylase )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AGMATIN__45__RXN" name="Agmatinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AGMAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( agmatinase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: arginine degradation III (arginine decarboxylase/agmatinase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AGMATHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOLACTOSE__45__RXN" name="&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MGC10771 ) or ( NA ) or ( FLJ90231 ) or ( GLB1 ) or ( LOC89944 ) or ( LGALS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-galactosidase precursor ) or ( beta-galactosidase precursor ) or ( beta-galactosidase precursor ) or ( beta-galactosidase precursor ) or ( beta-galactosidase precursor ) or ( GALECTIN-1 )</html:p>
<html:p>SUBSYSTEM: lactose degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOLACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1242" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__188__45__RXN" name="prostaglandin-F synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1C3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1 member C3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.188</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5Z13E__45__15S__45__9__45__ALPHA11__45__ALPHA15__45__TRIHY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__15S__45__9__45__ALPHA15__45__DIHYDROXY__45__11__45__O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__271__45__RXN" name="GDP-L-fucose synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TSTA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-fucose synthetase//GDP-mannose-4-keto-6-D epimerase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.271</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__92__45__RXN" name="Pantetheine hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( VNN1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PANTETHEINASE PRECURSOR )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.92</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__511" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__239" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALTODEXGLUCOSID__45__RXN" name="&amp;alpha;-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( G2AN ) or ( GAA ) or ( MGAM ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ALPHA GLUCOSIDASE II ALPHA SUBUNIT ) or ( lysosomal alpha-glucosidase precursor ) or ( maltase-glucoamylase, intestinal//maltase//glucoamylase ) or ( maltase-glucoamylase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.20</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__18__45__RXN" name="Phytanoyl-CoA dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PHYH ) or ( PHYHIP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phytanoyl-CoA dioxygenase, peroxisomal precursor ) or ( AMBIGUOUS )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.18</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__206" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXYPHYTANOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__PENTAPRENYLTRANSFERASE__45__RXN" name="all-trans-hexaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.33</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="ALL__45__TRANS__45__PENTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALL__45__TRANS__45__HEXAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SEPIAPTERIN__45__REDUCTASE__45__RXN" name="Sepiapterin reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( SPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SIMILAR TO SEPIAPTERIN REDUCTASE ) or ( sepiapterin reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.153</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__374" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCOSE_TO_UDP_COF_RXN" name="UDP-GLUCOSE_TO_UDP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__2__45__RXN" name="Dihydropyrimidine dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DPYD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydropyrimidine dehydrogenase (NADP+) precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLNEURAMINATE__45__CYTIDYLYLTRANSFERASE__45__RXN" name="Acylneuraminate cytidylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CMAS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine 5&apos;-monophosphate N-acetylneuraminic acid synthetase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.43</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1119" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__189" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6601" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( GGT1 ) or ( NA ) or ( GGTL4 ) or ( GGTL3 ) or ( GGT2 ) or ( GGTLA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma glutamyltranspeptidase ) or ( gamma-glutamyltranspeptidase 1 precursor ) or ( gamma glutamyltranspeptidase ) or ( gamma-glutamyl transpeptidase ) or ( GAMMA-GLUTAMYLTRANSFERASE-LIKE 3 ) or ( gamma-glutamyltranspeptidase 2 (fragment) ) or ( gamma-glutamyltranspeptidase 5 precursor )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 2.3.2.2</html:p>
<html:p>SIDE: __124__Amino__45__Acids__45__20__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYS__45__GLY" stoichiometry="1"/>
      <speciesReference species="_5__45__L__45__GLUTAMYL__45__L__45__AMINO__45__ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GANGLIOSIDE__45__GALACTOSYLTRANSFERASE__45__RXN" name="Ganglioside galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B3GALT4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.62</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1100" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7188" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__126__45__RXN" name="[Myelin basic protein]-arginine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ10640 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein arginine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.126</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Myelin__45__L__45__arginines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Myelin__45__N__45__o__45__methyl__45__arginines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__1__45__DEHYDROGENASE__45__RXN" name="Glucose 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( H6PD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDH/6PGL endoplasmic bifunctional protein precursor )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.47</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__D__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__DEHYDROGENASE__45__NADORNOP__43____45__RXN" name="Aldehyde dehydrogenase (NAD(P)+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH3B1 ) or ( ALDH1A3 ) or ( ALDH8A1 ) or ( ALDH3A1 ) or ( ALDH3B2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 7 ) or ( aldehyde dehydrogenase 1A3 ) or ( aldehyde dehydrogenase 8A1 isoform 1 ) or ( aldehyde dehydrogenase, dimeric NADP-preferring ) or ( aldehyde dehydrogenase 8 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.5</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG6PDEACET__45__RXN" name="N-acetylglucosamine-6-phosphate deacetylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CGI-14 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CGI-14 protein )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__19__46__3__45__RXN" name="Linoleoyl-CoA desaturase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FADS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty acid desaturase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.19.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__18" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__LINOLENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45__GLU__45__AMINOTRANSFORASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine aminotransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis V (from arginine)</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VII</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__OCTANOYLTRANSFERASE__45__RXN" name="Carnitine O-octanoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CROT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal carnitine octanoyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.137</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTANOYL__45__COA" stoichiometry="1"/>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="L__45__OCTANOYLCARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMPCYCLOHYDROLASE__45__RXN" name="IMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ATIC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional purine biosynthesis protein purh )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.10</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOKIN__45__RXN" name="Galactokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GALK1 ) or ( GALK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactokinase ) or ( N-acetylgalactosamine kinase )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Galactose__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__34__45__RXN" name="Hydroxymethylglutaryl-CoA reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HMGCR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl-coenzyme A reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__15__45__RXN" name="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DPAGT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.15</html:p>
<html:p>SIDE: UMP</html:p>
<html:p>SIDE: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
      <speciesReference species="CPD__45__190" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOPACHROME__45__DELTA__45__ISOMERASE__45__RXN" name="Dopachrome isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DCT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dopachrome tautomerase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DOPACHROME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_56__45__DIHYDROXYINDOLE__45__2__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__8__45__RXN" name="Saccharopine dehydrogenase (NADP+, L-lysine forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AASS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysine-ketoglutarate reductase /saccharopine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNP__45__RXN" name="Purine-nucleoside phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENMETSYN__45__RXN" name="Methionine adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MAT2A ) or ( MAT1A ) or ( MAT2B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine synthetase gamma form ) or ( S-adenosylmethionine synthetase alpha and beta forms ) or ( methionine adenosyltransferase II, beta )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: S-adenosylmethionine biosynthesis</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R22__45__RXN" name="Butyryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACADS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase, short-chain specific, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MRNA__45__GUANYLYLTRANSFERASE__45__RXN" name="mRNA guanylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RNGTT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mRNA capping enzyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.50</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
      <speciesReference species="CPD__45__8630" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8631" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SARCOX__45__RXN" name="Sarcosine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PIPOX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal sarcosine oxidase )</html:p>
<html:p>SUBSYSTEM: creatinine degradation I</html:p>
<html:p>SUBSYSTEM: creatinine degradation II</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__711" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SRD5A2 ) or ( SRD5A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxo-5-alpha-steroid 4-dehydrogenase 2 ) or ( 3-oxo-5-alpha-steroid 4-dehydrogenase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__698" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__709" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LYSOPHOSPHOLIPASE__45__RXN" name="Lysophospholipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PLA2G4A ) or ( FLJ30866 ) or ( LYPLA3 ) or ( CLC ) or ( LYPLA1 ) or ( LYPLA2 ) or ( NA ) or ( PP13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosolic phospholipase A2//phospholipase A2 ) or ( PHOSPHOLIPASE ADRAB B PRECURSOR ) or ( lysophospholipase 3 ) or ( eosinophil lysophospholipase ) or ( lysophospholipase i ) or ( lysophospholipase II ) or ( cytosolic phospholipase A2 cPLA2//phospholipase A2//ambiguous ) or ( placental protein 13 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__GLYCERO__45__PHOSPHORYLCHOLINE" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4229" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SRD5A2 ) or ( SRD5A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxo-5-alpha-steroid 4-dehydrogenase 2 ) or ( 3-oxo-5-alpha-steroid 4-dehydrogenase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3945" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3946" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHACYL__45__COA__45__DEHYDROG__45__RXN" name="3-hydroxyacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( HADH2 ) or ( HADHA ) or ( NA ) or ( EHHADH ) or ( HADHSC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal bifunctional enzyme PBE PBFE ) or ( 3-hydroxyacyl-CoA dehydrogenase type II ) or ( trifunctional enzyme alpha subunit, mitochondrial precursor ) or ( peroxisomal bifunctional enzyme PBE PBFE ) or ( peroxisomal bifunctional enzyme ) or ( short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.35</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__1__45__RXN" name="&amp;gamma;-butyrobetaine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BBOX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( gamma-butyrobetaine,2-oxoglutarate dioxygenase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-butyrobetaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.1</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: SUC</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAMMA__45__BUTYROBETAINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__141__45__RXN" name="15-hydroxyprostaglandin dehydrogenase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HPGD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 15-hydroxyprostaglandin dehydrogenase (NAD(+)) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.141</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5Z13E__45__15S__45__11__45__ALPHA15__45__DIHYDROXY__45__9__45__O__45__ENOAT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__11__45__ALPHA__45__HYDROXY__45__915__45__DIOXOPROS__45__ENO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DLACTDEHYDROGNAD__45__RXN" name="D-lactate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LDHD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-lactate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.28</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__REDUCTASE__45__RXN" name="Hydroxymethylglutaryl-CoA reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HMGCR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxy-3-methylglutaryl-coenzyme A reductase )</html:p>
<html:p>SUBSYSTEM: mevalonate degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.88</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7799" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CERK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceramide kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.138</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Plant__45__Ceramides__45__I__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Plant__45__Ceramide__45__Phosphate__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGANINE__45__1__45__PHOSPHATE__45__ALDOLASE__45__RXN" name="Sphinganine-1-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SGPL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sphingosine-1-phosphate lyase 1 )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.27</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__649" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PALMITALDEHYDE" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIPHOSPHATASE__45__RXN" name="Nucleoside-diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LYSAL1 ) or ( SHAPY ) or ( ENTPD6 ) or ( ENTPD5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleoside triphosphate diphosphohydrolase 4 ) or ( Ca2+-dependent endoplasmic reticulum nucleoside diphosphatase ) or ( ectonucleoside triphosphate diphosphohydrolase 6 ) or ( ectonucleoside triphosphate diphosphohydrolase 5 precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" name="L-ASPARTATE_TO_OXALACETIC_ACID_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__SULFOGLUCOSAMINE__45__SULFOHYDROLASE__45__RXN" name="N-sulfoglucosamine sulfohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SGSH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-sulphoglucosamine sulphohydrolase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.10.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__550" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSAMINE" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__213__45__RXN" name="3-&amp;alpha;-hydroxysteroid dehydrogenase (A-specific)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1C4 ) or ( AKR1C2 ) or ( AKR1C1 ) or ( AKR1C3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1 member C4 ) or ( aldo-keto reductase family 1 member C2 ) or ( aldo-keto reductase family 1 member C1 ) or ( aldo-keto reductase family 1 member C3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.213</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ANDROSTERONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__342" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OXOACID__45__COA__45__TRANSFERASE__45__RXN" name="3-oxoacid CoA-transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OXCT2 ) or ( OXCT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxoacid CoA transferase 2 ) or ( succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__3__45__OXO__45__ACID" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
      <speciesReference species="A__45__3__45__OXO__45__ACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__1__45__RXN" name="Formaldehyde dehydrogenase (glutathione)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase class III chi chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP_TO_UTP_COF_RXN" name="UDP_TO_UTP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADPH__45__DEHYDROGENASE__45__FLAVIN__45__RXN" name="NADPH dehydrogenase (flavin)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BLVRB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( flavin reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.30</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__316" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALLANTOICASE__45__RXN" name="Allantoicase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALLC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to allantoicase )</html:p>
<html:p>SUBSYSTEM: allantoin degradation to ureidoglycolate I (urea producing)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLANTOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1091" stoichiometry="1"/>
      <speciesReference species="UREA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLNEURAMINATE__45__SYNTHASE__45__RXN" name="N-acetylneuraminate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NANS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sialic acid synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLNEURAMINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Ubiquinones__124___TO___124__Ubiquinols__124___COF_RXN" name="|Ubiquinones|_TO_|Ubiquinols|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Ubiquinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ubiquinols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADP__45__RIBOSYLARGININE__45__HYDROLASE__45__RXN" name="ADP-ribosylarginine hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADPRH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-ribosylarginine hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.19</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__557" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE_DIPHOSPHATE_RIBOSE" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__L__45__Arginines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE_TO_UDP_COF_RXN" name="UDP-GLUCURONATE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__127__45__RXN" name="1D-myo-inositol-trisphosphate 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ITPKA ) or ( ITPKB ) or ( ITPKC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-D-myo-inositol-trisphosphate 3-kinase a ) or ( 1-D-myo-inositol-trisphosphate 3-kinase b ) or ( inositol 1,4,5-trisphosphate 3-kinase C )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.127</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYCYTIDINE__45__KINASE__45__RXN" name="Deoxycytidine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DCK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxycytidine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.74</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__47__45__RXN" name="4-trimethylammoniobutyraldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH9A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase, E3 isozyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.47</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__TRIMETHYLAMMONIOBUTANAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAMMA__45__BUTYROBETAINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLENE__45__THF_TO_DIHYDROFOLATE_COF_RXN" name="METHYLENE-THF_TO_DIHYDROFOLATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UGD__45__RXN" name="UDP-glucose 6-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose 6-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-D-xylose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MERCAPYSTRANS__45__RXN" name="3-mercaptopyruvate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MPST )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-mercaptopyruvate sulfurtransferase )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.2</html:p>
<html:p>SIDE: HSCN</html:p>
<html:p>SIDE: HCN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCN" stoichiometry="1"/>
      <speciesReference species="_3__45__MERCAPTO__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HSCN" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Choline O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline O-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.6</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__5__46__1__46__21__45__RXN" name="Farnesyl-diphosphate farnesyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FDFT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl-diphosphate farnesyltransferase )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROLINE__45__MULTI" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PYCS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta 1-pyrroline-5-carboxylate synthetase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEDEHYDR__45__RXN" name="Aconitate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACO1 ) or ( ACO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aconitase 1 ) or ( aconitate hydratase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: serine-isocitrate lyase pathway</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R481__45__RXN" name="Glycine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GNMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis IV (from glycine)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.156</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSEUDOURIDYLATE__45__SYNTHASE__45__RXN" name="Pseudouridylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RLUCL ) or ( FKSG32 ) or ( PUS1 ) or ( TRUB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribosomal large subunit pseudouridine synthase C like ) or ( probable pseudouridylate synthase 3 ) or ( tRNA pseudouridine synthase A ) or ( Trub pseudouridine (psi) synthase homolog 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.70</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PSEUDOURIDINE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIACYLGLYCEROL__45__LIPASE__45__RXN" name="Triacylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LIPH ) or ( CLPS ) or ( LIPC ) or ( PNLIPRP1 ) or ( PNLIPRP2 ) or ( NA ) or ( LIPG ) or ( LIPF ) or ( LIPE ) or ( LOC57406 ) or ( CEL ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( LIPASE, MEMBER H ) or ( colipase precursor ) or ( triacylglycerol lipase, hepatic precursor ) or ( triacylglycerol lipase, pancreatic precursor ) or ( pancreatic lipase related protein 2 precursor ) or ( NA ) or ( endothelial lipase precursor ) or ( triacylglycerol lipase, gastric precursor ) or ( hormone sensitive lipase ) or ( LIPASE PROTEIN ) or ( bile-salt-activated lipase precursor ) or ( NA )</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Fatty__45__Acids__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Diacylglycerides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHOSINEPHOSPHORY__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOPROTEIN__45__PHOSPHOLIPASE__45__D__45__RXN" name="Glycoprotein phospholipase D" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GPLD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol-glycan-specific phospholipase D 1 precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.50</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1113" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
      <speciesReference species="_6__45__ALPHA__45__D__45__GLUCOSAMINYL__45__1D__45__MYO__45__INOSIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINE__45__DEHYDROGENASE__45__RXN" name="Spermidine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( C20orf16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anon-37Cs )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.6</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__DELTA__45__ISOM__45__RXN" name="Dodecenoyl-CoA &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DCI ) or ( NA ) or ( PECI ) or ( NA ) or ( EHHADH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3,2-trans-enoyl-CoA isomerase, mitochondrial precursor ) or ( peroxisomal bifunctional enzyme PBE PBFE ) or ( peroxisomal 3,2-trans-enoyl-CoA isomerase ) or ( peroxisomal bifunctional enzyme PBE PBFE ) or ( peroxisomal bifunctional enzyme )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation III (unsaturated, odd number)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__DELTA3__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LIPOPROTEIN__45__LIPASE__45__RXN" name="Lipoprotein lipase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LPL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lipoprotein lipase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.34</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__GLN__45__FRUCT__45__6__45__P__45__AMINOTRANS__45__RXN" name="Glucosamine--fructose-6-phosphate aminotransferase (isomerizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GFPT2 ) or ( GFPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 2 ) or ( glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 1 )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.16</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ENOYL__45__COA__45__HYDRAT__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( FLJ10948 ) or ( HADHA ) or ( NA ) or ( EHHADH ) or ( ECHS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal bifunctional enzyme PBE PBFE ) or ( unknown ) or ( trifunctional enzyme alpha subunit, mitochondrial precursor ) or ( peroxisomal bifunctional enzyme PBE PBFE ) or ( peroxisomal bifunctional enzyme ) or ( enoyl-CoA hydratase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PALMITYL__45__COA_TO_CO__45__A_COF_RXN" name="PALMITYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PALMITYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__ASPARTATE__45__OXIDASE__45__RXN" name="D-aspartate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DDO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-aspartate oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__302" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__5781" name="Diacylglycerol cholinephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CEPT1 ) or ( CHPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline/ethanolaminephosphotransferase ) or ( choline phosphotransferase 1 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.2</html:p>
<html:p>SIDE: DIACYLGLYCEROL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__PEROXIDASE__45__RXN" name="glutathione peroxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPX1 ) or ( GPX5 ) or ( GPX4 ) or ( GPX6 ) or ( GPX2 ) or ( GPX3 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione peroxidase 1 ) or ( epididymal secretory glutathione peroxidase precursor ) or ( phospholipid hydroperoxide glutathione peroxidase, mitochondrial precursor ) or ( glutathione peroxidase 6 ) or ( glutathione peroxidase-gastrointestinal ) or ( plasma glutathione peroxidase precursor ) or ( glutathione peroxidase )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.9</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXI__45__RXN" name="Lactoylglutathione lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lactoylglutathione lyase )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.5</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="METHYL__45__GLYOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 51 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4573" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__304" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 51 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4568" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4573" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__ADRENERGIC__45__RECEPTOR__45__KINASE__45__RXN" name="[&amp;beta;-adrenergic-receptor] kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADRBK2 ) or ( ADRBK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-adrenergic receptor kinase 2 ) or ( beta-adrenergic receptor kinase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.126</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__BETA__45__ADRENERGIC__32__RECEPTOR__93__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__BETA__45__ADRENERGIC__32__RECEPTOR__93____32__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__303" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 51 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4568" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__139__45__RXN" name="1D-myo-inositol-trisphosphate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ITPK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol 1,3,4-triphosphate 5/6 kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.134</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__506" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__306" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TM7SF2 ) or ( LBR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta(14)-sterol reductase ) or ( lamin B receptor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENDECARBOX__45__RXN" name="Uroporphyrinogen decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UROD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen decarboxylase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.37</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYM__45__PHOSPH__45__RXN" name="Thymidine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ECGF1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine phosphorylase precursor )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.4</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXY__45__RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="THYMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__56__45__RXN" name="Inositol-1,4,5-trisphosphate 5-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SYNJ2 ) or ( PIB5PA ) or ( PPI5PIV ) or ( INPP5A ) or ( INPPL1 ) or ( INPP5E ) or ( INPP5B ) or ( SYNJ1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( synaptojanin 2 (fragment) ) or ( phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A ) or ( phosphatidylinositol (4,5) bisphosphate 5-phosphatase homolog ) or ( type I inositol-1,4,5-trisphosphate 5-phosphatase ) or ( inositol polyphosphate phosphatase-like 1 ) or ( mitochondrial processing peptidase alpha subunit, mitochondrial precursor ) or ( type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (fragment) ) or ( synaptojanin 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.56</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NME6 ) or ( NME4 ) or ( NME2 ) or ( NME3 ) or ( NME7 ) or ( NA ) or ( NME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase 6 ) or ( nucleoside diphosphate kinase, mitochondrial precursor ) or ( nucleoside diphosphate kinase B ) or ( nucleoside diphosphate kinase 3 ) or ( nucleoside diphosphate kinase 7 ) or ( putative nucleoside diphosphate kinase ) or ( nucleoside diphosphate kinase A )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH1B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase beta subunit )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to ethanol I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6423" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: putrescine degradation IV</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6124" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6421" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( C20orf16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anon-37Cs )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
      <speciesReference species="CPD__45__6121" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDATE__45__PHOSPHATASE__45__RXN" name="Phosphatidate phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PPAP2A ) or ( PPAP2B ) or ( PPAP2C )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidic acid phosphatase type 2A ) or ( phosphatidic acid phosphatase type 2B ) or ( phosphatidic acid phosphatase type 2C )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__318" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( H105E3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P)-dependent steroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4702" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4581" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__317" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4580" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4702" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__319" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD17B7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( estradiol 17 beta-dehydrogenase 7 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4581" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROPYRIMIDINASE__45__RXN" name="Dihydropyrimidinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DPYS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydropyrimidinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__URACIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__314" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD17B7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( estradiol 17 beta-dehydrogenase 7 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4578" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__METHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__313" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( H105E3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P)-dependent steroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4577" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4578" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__38__45__RXN" name="&amp;beta;-N-acetylglucosaminyl-glycopeptide &amp;beta;-1,4-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B4GALT3 ) or ( B4GALT2 ) or ( B4GALT1 ) or ( B4GALT5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-1,4-galactosyltransferase 3 ) or ( beta-1,4-galactosyltransferase 2 ) or ( beta-1,4-galactosyltransferase 1 ) or ( beta-1,4-galactosyltransferase 5 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.38</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8595" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8596" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__316" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4579" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4580" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__32__45__RXN" name="Phosphoenolpyruvate carboxykinase (GTP)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PCK2 ) or ( PCK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoenolpyruvate carboxykinase, mitochondrial precursor (GTP) ) or ( phosphoenolpyruvate carboxykinase, cytosolic (GTP) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.32</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__315" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__METHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4579" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__ACETYLTRANSFERASE__45__RXN" name="Carnitine O-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CRAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine O-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.7</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__ACETYLCARNITINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__42__45__RXN" name="Glycerone-phosphate O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GNPAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroxyacetone phosphate acyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.42</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__415" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGINASE__45__RXN" name="Arginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG2 ) or ( ARG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase II, mitochondrial precursor ) or ( arginase 1 )</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VII</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: UREA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_11__45__BETA__45__HYDROXYSTEROID__45__DEHYDROGENASE__45__RXN" name="11-&amp;beta;-hydroxysteroid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD11B1 ) or ( NA ) or ( HSD11B2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( corticosteroid 11-beta-dehydrogenase, isozyme 1 ) or ( corticosteroid 11 beta dehydrogenase isozyme 1 ) or ( corticosteroid 11-beta-dehydrogenase, isozyme 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.146</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__11__45__Beta__45__Hydroxysteroids1__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__11__45__Oxosteroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLATECYC__45__RXN" name="Adenylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADCY5 ) or ( ADCY1 ) or ( ADCY9 ) or ( ADCY7 ) or ( ADCY2 ) or ( ADCY4 ) or ( SAC ) or ( ADCYAP1R1 ) or ( ADCY8 ) or ( ADCY3 ) or ( ADCY6 ) or ( NA ) or ( NA ) or ( GPR3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylate cyclase, type v (fragment) ) or ( adenylate cyclase, type I (fragment) ) or ( adenylate cyclase, type IX ) or ( adenylate cyclase, type VII ) or ( adenylate cyclase, type II (fragment) ) or ( adenylate cyclase, type IV ) or ( soluble adenylyl cyclase ) or ( PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE TYPE I RECEPTOR PRECURSOR ) or ( adenylate cyclase, type VIII ) or ( adenylate cyclase type III ) or ( adenylate cyclase, type VI ) or ( adenylate cyclase type ) or ( soluble adenylyl cyclase ) or ( probable G protein-coupled receptor GPR3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CAMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__310" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4575" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__311" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4575" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4576" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__312" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4576" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4577" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8655" name="Lipoate--protein ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MRPL30 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( LIPOATE-PROTEIN LIGASE, MITOCHONDRIAL PRECURSOR )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.63</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
      <speciesReference species="LIPOYL__45__AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__6__45__N__45__lipoyl__45__lysine__124__" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8654" name="Lipoate--protein ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MRPL30 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( LIPOATE-PROTEIN LIGASE, MITOCHONDRIAL PRECURSOR )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.63</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LIPOIC__45__ACID" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOYL__45__AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__1__45__RXN" name="&amp;beta;-galactosamide &amp;alpha;-2,6-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ST6GalII ) or ( SIAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE II ) or ( CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.1</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__26__45__BETA__45__D__45__GALA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIB5PISOM__45__RXN" name="Ribose 5-phosphate epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RPIA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose 5-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IPPISOM__45__RXN" name="Isopentenyl-diphosphate &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IDI2 ) or ( IDI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isopentenyl-diphosphate delta-isomerase 2 ) or ( isopentenyl-diphosphate delta-isomerase 1 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDINE__45__AMMONIA__45__LYASE__45__RXN" name="Histidine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HAL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidine ammonia-lyase )</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.3</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROCANATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__15__45__RXN" name="Methylenetetrahydrofolate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( MTHFD2 ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase mitochondrial precursor ) or ( bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor ) or ( bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase mitochondrial precursor ) or ( bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase mitochondrial precursor ) or ( bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: glycine degradation I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.15</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYPOXANPRIBOSYLTRAN__45__RXN" name="Hypoxanthine phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPRT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine-guanine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__323" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4187" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__320" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EBP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ZYMOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR24 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 24-dehydrocholesterol reductase precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.72</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1501" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PLA2G4C ) or ( PLA2G2E ) or ( PLA2G4B ) or ( PLA2G3 ) or ( PLA2G1B ) or ( NA ) or ( PLA2G6 ) or ( PLA2G12 ) or ( NA ) or ( PLA2G4A ) or ( PLA2G2D ) or ( IPLA2(GAMMA) ) or ( NA ) or ( PLA2G2F ) or ( PLA2G10 ) or ( YWHAZ ) or ( PLA2G5 ) or ( PLA2G2A ) or ( NA ) or ( PLA2G13 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase A2, group IVC ) or ( group IIE secretory phospholipase A2 precursor ) or ( phospholipase A2, group IVB ) or ( group III secretory phospholipase A2 precursor ) or ( phospholipase A2 precursor ) or ( phospholipase A2 ) or ( phospholipase A2, group VI (cytosolic, calcium-independent) ) or ( group XII secretory phospholipase A2 precursor ) or ( cytosolic phospholipase A2 cPLA2//phospholipase A2//ambiguous ) or ( cytosolic phospholipase A2//phospholipase A2 ) or ( group IID secretory phospholipase A2 precursor ) or ( intracellular membrane-associated calcium-independent phospholipase A2 gamma ) or ( phospholipase A2 ) or ( group IIF secretory phospholipase A2 precursor ) or ( group X secretory phospholipase A2 precursor ) or ( 14-3-3 protein zeta/delta ) or ( calcium-dependent phospholipase A2 precursor ) or ( phospholipase A2, membrane associated precursor ) or ( CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 ) or ( group XIII secretory phospholipase A2 precursor ) or ( phospholipase A2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.4</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="LINOLENIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8664" name="Indoleamine 2,3-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INDO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indoleamine 2,3-dioxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.52</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__TRYPTOPHAN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__formyl__45__D__45__kynurenine" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONDEHYDROG__45__RXN" name="Phosphogluconate dehydrogenase (decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PGD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase, decarboxylating )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexaprenyldihydroxybenzoate methyltransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: ubiquinone-6 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.-</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HEXAPRENYL__45__3__45__METHYL__45__5__45__HYDROXY__45__6__45__METHOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__30" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__133__45__RXN" name="1D-myo-inositol-trisphosphate 6-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ITPK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol 1,3,4-triphosphate 5/6 kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.134</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__3__45__4__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__505" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LEUKOTRIENE__45__C4__45__SYNTHASE__45__RXN" name="Leukotriene-C4 synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LTC4S )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( leukotriene C4 synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.20</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEUKOTRIENE__45__C4" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8892" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8665" name="Indoleamine 2,3-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INDO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indoleamine 2,3-dioxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.52</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMYLKYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOACYLASE__45__RXN" name="Aminoacylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACY1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminoacylase-1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.14</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__N__45__Acylated__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__L__45__Amino__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANINE__45__DEAMINASE__45__RXN" name="Guanine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GDA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.3</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYL__45__KIN__45__RXN" name="Guanylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( KIF13B ) or ( GUK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kinesin-like protein KIF13B ) or ( guanylate kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.8</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__154__45__RXN" name="Phosphatidylinositol-4-phosphate 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PIK3R3 ) or ( P101-PI3K ) or ( PIK3R2 ) or ( PIK3R4 ) or ( PIK3R1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 3-kinase regulatory gamma subunit ) or ( phosphoinositide-3-kinase, regulatory subunit, polypeptide p101 ) or ( phosphatidylinositol 3-kinase regulatory beta subunit ) or ( phosphoinositide-3-kinase, regulatory subunit 4, p150 ) or ( phosphatidylinositol 3-kinase regulatory alpha subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.154</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__1D__45__MYO__45__INOSITOL__45__34__45__BISPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__2__46__31__45__RXN" name="NAD(P)(+)--arginine ADP-ribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ART5 ) or ( ART3 ) or ( ART1 ) or ( DO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ecto-ADP-ribosyltransferase 5 precursor ) or ( ecto-ADP-ribosyltransferase 3 precursor ) or ( GPI-linked NAD ) or ( ecto-ADP-ribosyltransferase 4 precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.31</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__557" stoichiometry="1"/>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7908" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PCBD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pterin-4-alpha-carbinolamine dehydratase )</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.96</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOTIDE__45__PYROPHOSPHATASE__45__RXN" name="Nucleotide pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ENPP4 ) or ( ENPP2 ) or ( NA ) or ( ENPP3 ) or ( ENPP1 ) or ( MGC33971 ) or ( ENPP5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleotide pyrophosphatase/phosphodiesterase 4 ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 2//nucleotide pyrophosphatase ) or ( ectonucleotide pyrophosphatase/phosphodiesterase E NPP phosphodiesterase I/nucleotide pyrophosphatase phosphodiesterase I PD//nucleotide pyrophosphatase ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 3//nucleotide pyrophosphatase ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 1//nucleotide pyrophosphatase ) or ( ectonucleotide pyrophosphatase/phosphodiesterase E NPP phosphodiesterase I/nucleotide pyrophosphatase phosphodiesterase I PD//nucleotide pyrophosphatase ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 5 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.9</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Dinucleotide__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NUC__45__5__45__PHOSPHATE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__9__46__3__45__RXN" name="Selenide,water dikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SPS2 ) or ( NA ) or ( SPS ) or ( SPS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( selenide,water dikinase 2 ) or ( selenide water dikinase ) or ( selenide,water dikinase 1 ) or ( selenide,water dikinase 2 )</html:p>
<html:p>SUBSYSTEM: selenocysteine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.9.3</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__678" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SEPO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__145__45__RXN" name="3-&amp;beta;-hydroxy-&amp;delta;(5)-steroid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD3B2 ) or ( NA ) or ( HSD3B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II ) or ( 3-beta-hydroxysteroid dehydrogenase/delta 5 >4 isomerase 3beta HSD ) or ( 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type i )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.145</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3b__45__hydroxy__45__D5__45__steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__oxo__45__D5__45__steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6__45__PHOSPHOFRUCTO__45__2__45__KINASE__45__RXN" name="6-phosphofructo-2-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PFKFB1 ) or ( PFKFB3 ) or ( PFKFB2 ) or ( PFKFB4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1//6-phosphofructo-2-kinase ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4//6-phosphofructo-2-kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.105</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__535" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DGDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NME6 ) or ( NME4 ) or ( NME2 ) or ( NME3 ) or ( NME7 ) or ( NA ) or ( NME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase 6 ) or ( nucleoside diphosphate kinase, mitochondrial precursor ) or ( nucleoside diphosphate kinase B ) or ( nucleoside diphosphate kinase 3 ) or ( nucleoside diphosphate kinase 7 ) or ( putative nucleoside diphosphate kinase ) or ( nucleoside diphosphate kinase A )</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__C__45__PALMITOYLTRANSFERASE__45__RXN" name="Serine C-palmitoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SPTLC1 ) or ( SPTLC2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine palmitoyltransferase 1 ) or ( serine palmitoyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.50</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PALMITYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: PALMITYL__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEHYDROSPHINGANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTASE__45__RXN" name="Lactase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( LCT ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lactase phlorizin hydrolase precursor lactase glycosylceramidase//lactase//phlorizin hydrolase ) or ( lactase-phlorizin hydrolase precursor//lactase//phlorizin hydrolase ) or ( lactase phlorizin hydrolase precursor lactase glycosylceramidase//lactase//phlorizin hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.108</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7710" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GBE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,4-alpha-glucan branching enzyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYRAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__2__46__23__45__RXN" name="Heparin-glucosamine 3-O-sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HS3ST1 ) or ( HS3ST4 ) or ( HS3ST2 ) or ( HS3ST3B1 ) or ( HS3ST3A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1 precursor ) or ( heparan sulfate (glucosamine) 3-O-sulfotransferase 4 ) or ( heparan sulfate D-glucosaminyl  3-O-sulfotransferase 2 ) or ( heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1 ) or ( heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.23</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HEPARIN__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEPARIN__45__GLUCOSAMINE__45__3__45__O__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Glycine N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GNMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis IV (from glycine)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.156</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RETINOL__45__DEHYDROGENASE__45__RXN" name="Retinol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RODH ) or ( RDH8 ) or ( RDH5 ) or ( ADH7 ) or ( RDH10 ) or ( RDH11 ) or ( RDH12 ) or ( RDH13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxysteroid epimerase ) or ( photoreceptor outer segment all-trans retinol dehydrogenase ) or ( 11-cis retinol dehydrogenase ) or ( alcohol dehydrogenase class IV mu/sigma chain ) or ( retinol dehydrogenase 10 ) or ( androgen-regulated short-chain dehydrogenase/reductase 1 ) or ( ambiguous ) or ( ambiguous )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.105</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RETINOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RETINAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__210__45__RXN" name="3-&amp;beta;(or 20-&amp;alpha;)-hydroxysteroid dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD3B2 ) or ( HSD3B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II ) or ( 3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type i )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.210</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__ANDROSTAN__45__3BETA17BETA__45__DIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_17__45__BETA__45__HYDROXY__45__5ALPHA__45__ANDROSTAN__45__3__45__O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7913" name="Cytidylate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UMP-CMPK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UMP-CMP kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DCDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__37__45__RXN" name="Glycoprotein-fucosylgalactoside &amp;alpha;-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ABO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histo-blood group ABO system transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.37</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOPROTEIN__45__ETCETERA__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Galactosyl__45__fucosyl__45__galactosyl__45__R__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHMETHYLBILANESYN__45__RXN" name="Hydroxymethylbilane synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HMBS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( porphobilinogen deaminase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.61</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R83__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MASA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( E-1 enzyme )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__HYDROXY__45__3__45__KETO__45__5__45__METHYLTHIO__45__1__45__PHOSPHOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BISPHOSPHOGLYCERATE__45__MUTASE__45__RXN" name="Bisphosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BPGM ) or ( PGAM1 ) or ( NA ) or ( PGAM2 ) or ( PGAM1 ) or ( NA ) or ( NA ) or ( PGAM1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bisphosphoglycerate mutase ) or ( phosphoglycerate mutase 1 ) or ( phosphoglycerate mutase ) or ( phosphoglycerate mutase 2 ) or ( phosphoglycerate mutase 1 ) or ( phosphoglycerate mutase ) or ( phosphoglycerate mutase ) or ( phosphoglycerate mutase 1 ) or ( phosphoglycerate mutase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_23__45__DIPHOSPHOGLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLCROTONYL__45__COA__45__CARBOXYLASE__45__RXN" name="Methylcrotonyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MCCC2 and MCCC1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( METHYLCROTONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL PRECURSOR and METHYLCROTONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL PRECURSOR )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__3__45__METHYL__45__GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PFRUCTPHOS__45__RXN" name="6-phosphofructokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PFKP ) or ( PFKM ) or ( PFKL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructokinase, type c ) or ( 6-phosphofructokinase, muscle type ) or ( 6-phosphofructokinase, liver type )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__150__45__RXN" name="N-acetyllactosaminide &amp;beta;-1,6-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GCNT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.150</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__16__45__ETCETERA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSCHOL__45__RXN" name="Phospholipase D" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PLD1 ) or ( PLD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase D1 ) or ( phospholipase D2 )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BADH__45__RXN" name="Betaine-aldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH9A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase, E3 isozyme )</html:p>
<html:p>SUBSYSTEM: choline degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis I (Gram-negative bacteria)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.8</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XANTHINE__45__OXIDASE__45__RXN" name="Xanthine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( XDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase/oxidase//xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTOTHENATE__45__KIN__45__RXN" name="Pantothenate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PANK4 ) or ( PANK3 ) or ( PANK2 ) or ( PANK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pantothenate kinase 4 ) or ( pantothenate kinase 3 ) or ( pantothenate kinase 2 ) or ( pantothenate kinase 1 )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTOTHENATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__P__45__PANTOTHENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOGEN__45__BRANCH__45__RXN" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GBE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,4-alpha-glucan branching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis I (from ADP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENODEAMIN__45__RXN" name="Adenosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ESTRONE__45__SULFOTRANSFERASE__45__RXN" name="Estrone sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( STE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( estrogen sulfotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.4</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ESTRONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ESTRONE__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATEDECARB__45__RXN" name="Pyruvate dehydrogenase (lipoamide)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PDHA1 ) or ( PDHB ) or ( PDHA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial precursor ) or ( pyruvate dehydrogenase E1 component beta subunit, mitochondrial precursor ) or ( pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.4.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LIPOAMIDE" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ACETYLDIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINEOXID__45__RXN" name="Amine oxidase (copper-containing)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MAOA ) or ( AOC2 ) or ( MAOB ) or ( AOC3 ) or ( NA ) or ( ABP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amine oxidase (flavin-containing) A ) or ( retina-specific copper amine oxidase precursor ) or ( amine oxidase (flavin-containing) B ) or ( membrane copper amine oxidase ) or ( amine oxidase ) or ( amiloride-sensitive amine oxidase (copper-containing) precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.21</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYLPHOSPHATASE__45__RXN" name="Aryldialkylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PON1 ) or ( PON2 ) or ( PON3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serum paraoxonase/arylesterase 1 ) or ( serum paraoxonase/arylesterase 2 ) or ( serum paraoxonase/arylesterase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Dialkyl__45__Phosphate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
      <speciesReference species="__124__Dialkyl__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE__45__CARBOXYLASE__45__RXN" name="Pyruvate carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate carboxylase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: aspartate biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__LACTAMASE__45__RXN" name="&amp;beta;-lactamase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LACTB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L56 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.6</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__Lactams__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8550" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXNI__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( OXCT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinyl-CoA:3-ketoacid-coenzyme A transferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__1__46__99__46__4__45__RXN" name="&amp;alpha;-methylacyl-CoA racemase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AMACR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-methylacyl-CoA racemase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__2__45__METHYLACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="R__45__2__45__METHYLACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__1__46__45__45__RXN" name="Aminocarboxymuconate-semialdehyde decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACMSD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminocarboxymuconate semialdehyde decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__3__45__OXOPROP__45__2__45__ENYL__45__BUT__45__2__45__ENEDI" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYCEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Diacylglycerol O-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DGAT1 ) or ( DGAT2 ) or ( DGAT2L1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diacylglycerol O-acyltransferase 1 ) or ( diacylglycerol O-acyltransferase homolog 2 ) or ( DIACYLGLYCEROL O-ACYLTRANSFERASE 2 LIKE 1 )</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.20</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Triacylglycerols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEPHOSPHOCOAKIN__45__RXN" name="Dephospho-CoA kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ22955 ) or ( NBP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleotide binding NBP ) or ( nucleotide binding protein )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__11__46__1__46__15__45__RXN" name="Peroxiredoxin" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PRDX1 ) or ( PRDX4 ) or ( PRDX2 ) or ( PRDX3 ) or ( PRDX5 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PEROXIREDOXIN 1 ) or ( PEROXIREDOXIN 4 ) or ( PEROXIREDOXIN 2 ) or ( THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL PRECURSOR ) or ( PEROXIREDOXIN 5, MITOCHONDRIAL PRECURSOR ) or ( PEROXIREDOXIN 5 MITOCHONDRIAL PRECURSOR PRX V PEROXISOMAL ANTIOXIDANT ENZYME PLP THIOREDOXIN PEROXIDASE PMP20 ANTIOXIDANT ENZYME B166 AOEB166 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="2"/>
      <speciesReference species="__124__Alkyl__45__Hydro__45__Peroxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__97__45__RXN" name="Glycylpeptide N-tetradecanoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NMT2 ) or ( NMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycylpeptide N-tetradecanoyltransferase 2 ) or ( glycylpeptide N-tetradecanoyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.97</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRADECANOYL__45__COA" stoichiometry="1"/>
      <speciesReference species="GLYCYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__TETRADECANOYLGLYCYL__45__PEPTIDE" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBULP3EPIM__45__RXN" name="ribulose phosphate 3-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RPE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribulose-5-phosphate-3-epimerase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTOSE__45__SYNTHASE__45__RXN" name="Lactose synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LALBA ) or ( B4GALT2 ) or ( B4GALT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-lactalbumin precursor ) or ( beta-1,4-galactosyltransferase 2 ) or ( beta-1,4-galactosyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.22</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R17__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SQRDL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL PRECURSOR )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.5.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S8" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOHEXOKINASE__45__RXN" name="Ketohexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( KHK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ketohexokinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__2__46__29__45__RXN" name="[Heparan sulfate]-glucosamine 3-sulfotransferase 2" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HS3ST2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heparan sulfate D-glucosaminyl  3-O-sulfotransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.29</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HEPARIN__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEPARIN__45__GLUCOSAMINE__45__3__45__O__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACONITATEHYDR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACO1 ) or ( ACO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Aconitase 1 ) or ( aconitate hydratase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: serine-isocitrate lyase pathway</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CIS__45__ACONITATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LACTALDDEHYDROG__45__RXN" name="Lactaldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH3B1 ) or ( ALDH3A2 ) or ( ALDH9A1 ) or ( ALDH1A1 ) or ( ALDH3B2 ) or ( NA ) or ( ALDH7A1 ) or ( ALDH1A3 ) or ( ALDH8A1 ) or ( MGC10204 ) or ( ALDH1B1 ) or ( NA ) or ( ALDH3A1 ) or ( ALDH1A2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 7 ) or ( fatty aldehyde dehydrogenase ) or ( aldehyde dehydrogenase, E3 isozyme ) or ( aldehyde dehydrogenase 1A1 ) or ( aldehyde dehydrogenase 8 ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase family 7 member A1 ) or ( aldehyde dehydrogenase 1A3 ) or ( aldehyde dehydrogenase 8A1 isoform 1 ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase x, mitochondrial precursor ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase, dimeric NADP-preferring ) or ( aldehyde dehydrogenase 1A2 )</html:p>
<html:p>SUBSYSTEM: L-lactaldehyde degradation (aerobic)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.22</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE_TO_UDP_COF_RXN" name="UDP-N-ACETYL-D-GLUCOSAMINE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5114" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSPHL ) or ( PSPH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-3-phosphoserine phosphatase homolog ) or ( L-3-phosphoserine phosphatase )</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTIDINE__45__DECARBOXYLASE__45__RXN" name="Histidine decarboxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HDC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histidine decarboxylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HIS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HISTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R223__45__RXN" name="long-chain-fatty-acid-CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( FACL3 ) or ( BUCS1 ) or ( FACL5 ) or ( FACL1 ) or ( FACL4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( long chain fatty acid CoA ligase ) or ( long-chain-fatty-acid--CoA ligase 3 ) or ( acetyl-coenzyme A synthetase 3 ) or ( long-chain-fatty-acid--CoA ligase 5 ) or ( long-chain-fatty-acid--CoA ligase 2 ) or ( long-chain-fatty-acid--CoA ligase 4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTANOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRIDOXKIN__45__RXN" name="Pyridoxal kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDXK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.35</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GPPSYN__45__RXN" name="Dimethylallyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( FDPS ) or ( GGPS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl pyrophosphate synthetase FPP synthetase FPS farnesyl diphosphate synthetase ) or ( farnesyl pyrophosphate synthetase ) or ( geranylgeranyl pyrophosphate synthetase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4211" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNCARBAMTRANSFER__45__RXN" name="Ornithine carbamoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OTC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine carbamoyltransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: citrulline degradation</html:p>
<html:p>SUBSYSTEM: proline biosynthesis V (from arginine)</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__FORMYL__45__THF__45__CYCLO__45__LIGASE__45__RXN" name="5-formyltetrahydrofolate cyclo-ligase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MTHFS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-formyltetrahydrofolate cyclo-ligase )</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__5__45__MONOOXYGENASE__45__RXN" name="Tryptophan 5-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NTPH ) or ( TPH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( neuronal tryptophan hydroxylase ) or ( tryptophan 5-monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
      <speciesReference species="_5__45__HYDROXY__45__TRYPTOPHAN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNKIN__45__RXN" name="D-mannose transport" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GCKR ) or ( HK3 ) or ( FLJ22761 ) or ( NA ) or ( GCK ) or ( HK2 ) or ( HK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucokinase regulatory protein ) or ( hexokinase type III ) or ( hexokinase ) or ( hexokinase ) or ( hexokinase D ) or ( hexokinase, type II ) or ( hexokinase, type I )</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.7</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8489" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TYR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosinase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8671" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8672" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINSYN__45__RXN" name="argininosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASS ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate synthase ) or ( argininosuccinate synthase ) or ( argininosuccinate synthase ) or ( argininosuccinate synthase ) or ( argininosuccinate synthase ) or ( argininosuccinate synthase ) or ( argininosuccinate synthase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8488" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TYR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosinase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8670" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8671" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__300" name="Glyoxylate reductase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GRHPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxylate reductase/hydroxypyruvate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INOPHOSPHOR__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOCYSMETB12__45__RXN" name="5-methyltetrahydrofolate--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MTR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-methyltetrahydrofolate--homocysteine methyltransferase )</html:p>
<html:p>SUBSYSTEM: homoserine and methionine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of lysine, threonine and methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: methionine and methyl-donor-molecule biosynthesis</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOPURINE__45__S__45__METHYLTRANSFERASE__45__RXN" name="Thiopurine S-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiopurine S-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.67</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Thiopurines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Thiopurine__45__Methylethers__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NFS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine desulfurase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis III</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ENZYME__45__S__45__SULFANYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATASE__45__RXN" name="Glucose-6-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LOC92579 ) or ( G6PC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose 6 phosphatase ) or ( glucose-6-phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AGL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen debranching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOTETRAOSE" stoichiometry="1"/>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KYNURENINE__45__3__45__MONOOXYGENASE__45__RXN" name="Kynurenine 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( KMO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynurenine 3-monooxygenase )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.9</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDINEKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UCK1 ) or ( UMPK ) or ( URKL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine-cytidine kinase 1 ) or ( uridine-cytidine kinase 2 ) or ( uridine kinase-like 1 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOVALERYL__45__COA__45__FAD__45__RXN" name="Isovaleryl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IVD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isovaleryl-CoA dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTONE__45__LYSINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Histone-lysine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SUV39H1 ) or ( SET7 ) or ( NA ) or ( BAT8 ) or ( DOT1L ) or ( SET07 ) or ( SUV39H2 ) or ( SETDB1 ) or ( Eu-HMTase1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histone-lysine N-methyltransferase, H3 lysine-9 specific 1 ) or ( histone-lysine N-methyltransferase, H3 lysine-4 specific ) or ( histone lysine N-methyltransferase H3 lysine 9 specific 3 ) or ( histone-lysine N-methyltransferase, H3 lysine-9 specific 3 ) or ( histone-lysine N-methyltransferase, H3 lysine-79 specific ) or ( histone-lysine N-methyltransferase, H4 lysine-20 specific ) or ( histone-lysine N-methyltransferase, H3 lysine-9 specific 2 ) or ( histone-lysine N-methyltransferase, H3 lysine-9 specific 4 ) or ( histone-lysine N-methyltransferase, H3 lysine-9 specific 5 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.43</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8578" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8579" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FADSYN__45__RXN" name="FMN adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PP591 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ambiguous )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="FMN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R82__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MASA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( E-1 enzyme )</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__84" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__HYDROXY__45__3__45__KETO__45__5__45__METHYLTHIO__45__1__45__PHOSPHOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPHOSPHOR__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxybutyrate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.30</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__335" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTAMINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Histamine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HNMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.8</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HISTAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__METHYL__45__HISTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__N__45__ACETYLGLUCOSAMINE__45__4__45__EPIMERASE__45__RXN" name="UDP-N-acetylglucosamine 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GALE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose 4-epimerase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__GALACTOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROCOLLAGEN__45__LYSINE__45__5__45__DIOXYGENASE__45__RXN" name="Procollagen-lysine 5-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PLOD2 ) or ( PLOD ) or ( PLOD3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 precursor ) or ( procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor ) or ( procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.4</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROCOLLAGEN__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROCOLLAGEN__45__5__45__HYDROXY__45__L__45__LYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8853" name="Sepiapterin reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( SPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SIMILAR TO SEPIAPTERIN REDUCTASE ) or ( sepiapterin reductase )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.153</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8854" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( SPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SIMILAR TO SEPIAPTERIN REDUCTASE ) or ( sepiapterin reductase )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__LACTOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPDEPHOS__45__RXN" name="Pyruvate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PKLR ) or ( PKM2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate kinase, isozymes R/L ) or ( pyruvate kinase, M1 isozyme )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.40</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADSL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__RIBOSYL__45__4__45__SUCCCARB__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBDEHYDROG__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH4A1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 4A1 precursor ) or ( delta-1-pyrroline 5 carboxylate dehydrogenase mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: arginine degradation VII</html:p>
<html:p>SUBSYSTEM: proline degradation III</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8647" name="Arachidonate 5-lipoxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALOX5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 5-lipoxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.34</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6E8Z11Z14Z__45__5S__45__5__45__HYDROPEROXYCOSA__45__6" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8892" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOPORGENOXI__45__RXN" name="Protoporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PPOX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoporphyrinogen oxidase )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.4</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__43__45__RXN" name="[Pyruvate dehydrogenase (lipoamide)]-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( KIAA1348 ) or ( PDP ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate dehydrogenase phosphatase isoenzyme 2 ) or ( (pyruvate dehydrogenase (lipoamide))-phosphatase 1, mitochondrial precursor ) or ( (pyruvate dehydrogenase (lipoamide))-phosphatase 2, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.43</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__PYRUVATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93____32__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__PYRUVATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLU6PDEHYDROG__45__RXN" name="Glucose-6-phosphate 1-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( G6PD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate 1-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.49</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOSERDEAM__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CTH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine gamma-lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__181__45__RXN" name="Cholest-5-ene-3-&amp;beta;,7-&amp;alpha;-diol 3-&amp;beta;-dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD3B7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-beta-hydroxy-delta 5-C27-steroid oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.181</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__266" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1087" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NANK__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GNE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: N-acetylneuraminate and N-acetylmannosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.60</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__81" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FMO3 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dimethylaniline monooxygenase (N-oxide forming) 3 ) or ( DJ127D3.2 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2743" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__82" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( INMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indolethylamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.49</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3183" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FGAMSYN__45__RXN" name="phosphoribosylformylglycinamidine synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PFAS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoribosylformylglycinamidine synthase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARACHIDONATE__45__15__45__LIPOXYGENASE__45__RXN" name="Arachidonate 15-lipoxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALOX15 ) or ( ALOX15B ) or ( ALOX15B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 15-lipoxygenase ) or ( arachidonate 15-lipoxygenase, type II ) or ( arachidonate 15-lipoxygenase, type II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.33</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z8Z11Z13E__45__15S__45__15__45__HYDROPEROXYICOS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HOMOGENTISATE__45__12__45__DIOXYGENASE__45__RXN" name="Homogentisate 1,2-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HGD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( homogentisate 1,2-dioxygenase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.5</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__146" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ20359 ) or ( NA ) or ( FLJ40054 ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( CYP2A6 ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 2A6 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5305" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLMALONYL__45__COA__45__EPIM__45__RXN" name="Methylmalonyl-CoA epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MCEE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonyl-CoA epimerase )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 5.1.99.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLYLSULFKIN__45__RXN" name="Adenylylsulfate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAPSS2 ) or ( PAPSS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional 3&apos;-phosphoadenosine 5&apos;-phosphosulfate synthethase 2 ) or ( bifunctional 3&apos;-phosphoadenosine 5&apos;-phosphosulfate synthethase 1 )</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.25</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_PROPIONYL__45__COA_COF_RXN" name="CO-A_TO_PROPIONYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__66__45__RXN" name="Inositol-3,4-bisphosphate 4-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INPP4A ) or ( INPP4B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate-4-phosphatase, type 1 isoform B ) or ( inositol polyphosphate-4-phosphatase, type II, 105kD )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.66</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__PHOSPHATIDYL__45__MYO__45__INOSITOL__45__34__45__BISPHOSP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2901" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ABAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8632" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1B10 ) or ( AKR1B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 ) or ( aldose reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation III</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPANE__45__1__45__2__45__DIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GABATRANSAM__45__RXN" name="4-aminobutyrate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ABAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-aminobutyrate aminotransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation I</html:p>
<html:p>SUBSYSTEM: glutamate degradation IX (via 4-aminobutyrate)</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation III</html:p>
<html:p>SUBSYSTEM: glutamate degradation III (via 4-aminobutyrate)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.19</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLSULFAT__45__RXN" name="Arylsulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( KIAA1001 ) or ( SULF1 ) or ( ARSD ) or ( SULF2 ) or ( ARSF ) or ( ARSE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylsulfatase precursor ) or ( sulfatase 1 ) or ( arylsulfatase D precursor ) or ( similar to glucosamine-6-sulfatases ) or ( arylsulfatase F precursor ) or ( arylsulfatase E precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Sulfate__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__83" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A4 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2744" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__ATP__45__RXN" name="DNA ligase (ATP)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LIG3 ) or ( LIG1 ) or ( LIG4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA ligase III ) or ( DNA ligase I ) or ( DNA ligase IV )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA__45__DEHYDROGENASE__45__NADP__43____45__RXN" name="Acyl-CoA dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PECR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal trans-2-enoyl CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_SUC_COF_RXN" name="2-KETOGLUTARATE_TO_SUC_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__3__46__2__46__9__45__RXN" name="Microsomal epoxide hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( EPHX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( epoxide hydrolase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8984" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8985" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__OXYGENASE__45__RXN" name="Myo-inositol oxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDRL6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde reductase (aldose reductase) like 6 )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-glucuronate biosynthesis (from myo-inositol)</html:p>
<html:p>PROTEIN_CLASS: 1.13.99.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIAMIN__45__TRIPHOSPHATASE__45__RXN" name="Thiamine-triphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( THTPA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamine triphosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__611" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GSHTRAN__45__RXN" name="Glutathione transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( GSTA5 ) or ( GSTT2 ) or ( GSTT1 ) or ( MGST3 ) or ( GSTM4 ) or ( GSTA4 ) or ( MGST2 ) or ( MGST1 ) or ( GSTP1 ) or ( GSTZ1 ) or ( GSTA3 ) or ( GSTA2 ) or ( GSTM2 ) or ( GSTM3 ) or ( GSTM1 ) or ( GSTM5 ) or ( GSTTLp28 ) or ( LOC51064 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione S-transferase ) or ( glutathione S-transferase A1 ) or ( glutathione S-transferase theta 2 ) or ( glutathione S-transferase theta 1 ) or ( microsomal glutathione S-transferase 3 ) or ( glutathione S-transferase mu 4 ) or ( glutathione S-transferase A4-4 ) or ( microsomal glutathione S-transferase 2 ) or ( microsomal glutathione S-transferase 1 ) or ( glutathione S-transferase P ) or ( maleylacetoacetate isomerase ) or ( glutathione S-transferase A3-3 ) or ( glutathione S-transferase A2 ) or ( glutathione A-transferase mu 2 ) or ( glutathione S-transferase mu 3 ) or ( glutathione S-transferase mu 1 ) or ( glutathione S-transferase mu 5 ) or ( glutathione transferase omega 1 ) or ( glutathione S-transferase, mitochondrial ) or ( glutathione S-transferase )</html:p>
<html:p>SUBSYSTEM: glutathione-mediated detoxification</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.18</html:p>
<html:p>SIDE: HX</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RX" stoichiometry="1"/>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HX" stoichiometry="1"/>
      <speciesReference species="__124__S__45__Substituted__45__Glutathione__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__REDUCT__45__RXN" name="GMP reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GMPR2 ) or ( GMPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GMP reductase 2 ) or ( GMP reductase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.7.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( RRM2 ) or ( RRM2B ) or ( RRM1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribonucleoside diphosphate reductase chain ) or ( ribonucleoside-diphosphate reductase M2 chain ) or ( ribonucleoside diphosphate reductase chain ) or ( ribonucleoside-diphosphate reductase M1 chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.17.4.-</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxy__45__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTARYL__45__COA__45__DEHYDROGENASE__45__RXN" name="Glutaryl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GCDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl-CoA dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TYR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosinase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8851" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMATE__45__FORMIMINOTRANSFERASE__45__RXN" name="Glutamate formiminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FTCD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formimidoyltransferase-cyclodeaminase )</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.5</html:p>
<html:p>SIDE: THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__FORMIMINO__45__L__45__GLUTAMATE" stoichiometry="1"/>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__671" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAG1P__45__URIDYLTRANS__45__RXN" name="UDP-N-acetylglucosamine pyrophosphorylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( UAP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( unknown//unknown ) or ( UDP-N-acetylhexosamine pyrophosphorylase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.23</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R147__45__RXN" name="Acireductone dioxygenase (Fe(2+)-requiring)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: methionine salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.54</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__85" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__479" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADDALT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosine deaminase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYINOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__METHYLTHIOADENOSINE__45__PHOSPHORYLASE__45__RXN" name="5&apos;-methylthioadenosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MTAP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5&apos;-methylthioadenosine phosphorylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.28</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__444" stoichiometry="1"/>
      <speciesReference species="ADENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ20359 ) or ( NA ) or ( FLJ40054 ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( CYP2A6 ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 2A6 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2750" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__28__45__RXN" name="Phenylethanolamine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PNMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylethanolamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.28</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYLETHANOLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__METHYLPHENYLETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINE__45__KINASE__45__RXN" name="Ethanolamine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CHKL ) or ( EKI1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine O-palmitoyltransferase I, mitochondrial muscle isoform ) or ( ethanolamine kinase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.82</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TREHALA__45__RXN" name="&amp;alpha;,&amp;alpha;-trehalase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( TREH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trehalase precursor ) or ( trehalase precursor )</html:p>
<html:p>SUBSYSTEM: trehalose degradation II (trehalase)</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.28</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__163" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ20359 ) or ( NA ) or ( FLJ40054 ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( CYP2A6 ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 2A6 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2751" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PORPHOBILSYNTH__45__RXN" name="Porphobilinogen synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALAD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta-aminolevulinic acid dehydratase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.24</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PORPHOBILINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__6__45__RXN" name="N-acetyllactosaminide &amp;alpha;-2,3-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SIAT6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.6</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__14__45__N__45__ACETYL__45__ETCETERA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__23__45__BETA__45__ETCETER" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__168" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A4 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2747" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__169" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ20359 ) or ( NA ) or ( FLJ40054 ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( CYP2A6 ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 2A6 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3188" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5184" name="Phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PHKG1 ) or ( PHKG2 ) or ( PYGL ) or ( PHKA1 ) or ( PYGB ) or ( PYGM ) or ( PHKA2 ) or ( PHKB ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform ) or ( phosphorylase b kinase gamma catalytic chain, testis/liver isoform ) or ( glycogen phosphorylase, liver form ) or ( phosphorylase b kinase alpha regulatory chain, skeletal muscle isoform ) or ( glycogen phosphorylase, brain form ) or ( glycogen phosphorylase, muscle form ) or ( phosphorylase b kinase alpha regulatory chain, liver isoform ) or ( phosphorylase b kinase beta regulatory chain ) or ( phosphorylase b )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R344__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MMAB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)alamin adenosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__694" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PUTRESCINE__45__OXIDASE__45__RXN" name="Putrescine oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MAOB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amine oxidase (flavin-containing) B )</html:p>
<html:p>SUBSYSTEM: putrescine degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.10</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__157__45__RXN" name="N-acetylgalactosamine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GALK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylgalactosamine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.157</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3604" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7246" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5181" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( AMY1A ) or ( AMY2A ) or ( AMY1A ) or ( AMY2B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-amylase precursor ) or ( alpha-amylase, salivary precursor ) or ( alpha-amylase, pancreatic precursor ) or ( alpha-amylase, salivary precursor ) or ( alpha-amylase 2B precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOHEXAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__62" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AOX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2742" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__61" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ20359 ) or ( NA ) or ( FLJ40054 ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( CYP2A6 ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 2A6 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 )</html:p>
<html:p>SUBSYSTEM: nicotine degradation III</html:p>
<html:p>SUBSYSTEM: nicotine degradation II</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRROLINECARBREDUCT__45__RXN" name="Pyrroline-5-carboxylate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( P5CR2 ) or ( PYCR1 ) or ( FLJ13852 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyrroline 5-carboxylate reductase isoform ) or ( pyrroline-5-carboxylate reductase ) or ( pyrroline 5 carboxylate reductase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis V (from arginine)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPCARBTRANS__45__RXN" name="Aspartate carbamoyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CAD protein )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.2</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8243" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation VII</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETO__45__6__45__AMINO__45__CAPROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINOPENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__3" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: (  )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation II (MEOS)</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__1" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TYRP1 ) or ( CAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5,6-DIHYDROXYINDOLE-2-CARBOXYLIC ACID OXIDASE PRECURSOR ) or ( catalase subunit )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__24__45__RXN" name="Mitogen-activated protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MAPK12 ) or ( MAPK4 ) or ( MAPK3 ) or ( MAPK8IP3 ) or ( MAPK9 ) or ( MAPK8 ) or ( MAPK8IP1 ) or ( MAPK1 ) or ( MAPK8IP2 ) or ( MAPK6 ) or ( MAPK7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MITOGEN-ACTIVATED PROTEIN KINASE 12 ) or ( MITOGEN-ACTIVATED PROTEIN KINASE 4 ) or ( mitogen-activated protein kinase 3 ) or ( C-JUN-AMINO-TERMINAL KINASE INTERACTING PROTEIN 3 ) or ( MITOGEN-ACTIVATED PROTEIN KINASE 9 ) or ( mitogen-activated protein kinase 8 ) or ( C-JUN-AMINO-TERMINAL KINASE INTERACTING PROTEIN 1 ) or ( mitogen-activated protein kinase 1 ) or ( C-JUN-AMINO-TERMINAL KINASE INTERACTING PROTEIN 2 ) or ( MITOGEN-ACTIVATED PROTEIN KINASE 6 ) or ( MITOGEN-ACTIVATED PROTEIN KINASE 7 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.24</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8816" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation VIII</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7682" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ20359 ) or ( NA ) or ( FLJ40054 ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( CYP2E1 ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome P450 2E1 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 ) or ( cytochrome p450 ) or ( CYTOCHROME P450 2 )</html:p>
<html:p>SUBSYSTEM: oxidative ethanol degradation II (MEOS)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ETOH" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRCARBOXY__45__RXN" name="Phosphoribosylaminoimidazole carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAICS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( multifunctional protein ADE2 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.21</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__CARBOXY__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIENOYLCOAREDUCT__45__RXN" name="2,4-dienoyl-CoA reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DECR1 ) or ( DECR2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2,4-dienoyl-CoA reductase, mitochondrial precursor ) or ( peroxisomal 2,4-dienoyl-CoA reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="T2__45__DECENOYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="T2__45__C4__45__DECADIENYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROSTAGLANDIN__45__E2__45__9__45__REDUCTASE__45__RXN" name="Prostaglandin-E2 9-reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CBR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbonyl reductase (NADPH) 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.189</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5Z13E__45__15S__45__91115__45__TRIHYDROXYPROSTA__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__15S__45__1115__45__DIHYDROXY__45__9__45__OXOPROS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="POLYAMINE__45__OXIDASE__45__RXN" name="Polyamine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( C20orf16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anon-37Cs )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N1__45__ACETYLSPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
      <speciesReference species="CPD__45__568" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1__45__PHOSPHATE__45__SYNTHASE__45__RXN" name="myo-inositol-1-phosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ISYNA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myo-inositol 1-phosphate synthase A1 )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.5.1.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINO__45__CARBOXYMUCONATE__45__SEMIALDEHYDE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACMSD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aminocarboxymuconate semialdehyde decarboxylase )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.45</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINOMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXII__45__RXN" name="Hydroxyacylglutathione hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MGC2605 ) or ( HAGH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacylglutathione hydrolase ) or ( hydroxyacylglutathione hydrolase )</html:p>
<html:p>SUBSYSTEM: superpathway of methylglyoxal degradation</html:p>
<html:p>SUBSYSTEM: methylglyoxal degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.6</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLUTATHIONE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__LACTOYL__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
      <speciesReference species="D__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9106" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SOLANESYL__45__PYROPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9610" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLCHOLINESTERASE__45__RXN" name="Acetylcholinesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACHE ) or ( COLQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetylcholinesterase precursor ) or ( acetylcholinesterase collagenic tail peptide precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9104" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( XYLT1 ) or ( XYLT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylosyltransferase i ) or ( xylosyltransferase II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.24</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_14__45__BETA__45__D__45__XYLANS" stoichiometry="1"/>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
      <speciesReference species="_14__45__BETA__45__D__45__XYLANS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHATIDYLINOSITOL__45__BISPHOSPHATASE__45__RXN" name="Phosphatidylinositol-bisphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OCRL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate 5-phosphatase OCRl-1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.36</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__79__45__RXN" name="galactosylgalactosylglucosylceramide &amp;beta;-D-acetyl- galactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B3GALT3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-gal:betaglcnac beta-1,3-galactosyltransferase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.79</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTOSYL__45__14__45__D__45__GALACTOSYL__45__14__45__D__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GALACTOSAMINYL__45__13__45__D__45__GALACT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__181" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP2B6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 2B6 )</html:p>
<html:p>SUBSYSTEM: bupropion degradation</html:p>
<html:p>PROTEIN_CLASS: 1.14.14.1</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__3481" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__3483" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THROMBOXANE__45__A__45__SYNTHASE__45__RXN" name="thromboxane-A synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TBXAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thromboxane-A synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROSTAGLANDIN__45__H2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA11__45__ALPHA__45__EPOXY__45__15__45__HYDROXYTHROMBA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALEYLACETOACETATE__45__ISOMERASE__45__RXN" name="Maleylacetoacetate isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSTZ1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maleylacetoacetate isomerase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__MALEYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDASE__45__RXN" name="Ceramidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASAH2 ) or ( ASAH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 ) or ( acid ceramidase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.23</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="SPHINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Amine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indolethylamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.49</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__All__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__45__METHYLATED__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5199" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: degradation of purine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA__45__DECARBOXYLASE__45__RXN" name="Malonyl-CoA decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MLYCD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malonyl-CoA decarboxylase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP cyclohydrolase I" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GCH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GTP cyclohydrolase I )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.16</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__33__45__RXN" name="Amylo-1,6-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AGL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen debranching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.33</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: GLC</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Truncated__45__Limit__45__Dextrins__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__SYNTHASE__45__RXN" name="Hydroxymethylglutaryl-CoA synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HMGCS1 ) or ( HMGCS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxymethylglutaryl-CoA synthase, cytoplasmic ) or ( hydroxymethylglutaryl-CoA synthase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.10</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHA__45__AMYL__45__RXN" name="&amp;alpha;-amylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( AMY1A ) or ( AMY2A ) or ( AMY1A ) or ( AMY2B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-amylase precursor ) or ( alpha-amylase, salivary precursor ) or ( alpha-amylase, pancreatic precursor ) or ( alpha-amylase, salivary precursor ) or ( alpha-amylase 2B precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALTOPENTAOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINEPNACETYLTRANS__45__RXN" name="Glucosamine-phosphate N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( GNPNAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SIMILAR TO GLUCOSAMINE-PHOSPHATE N-ACETYLTRANSFERASE ) or ( glucosamine-phosphate N-acetyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.4</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOASYN__45__RXN" name="long-chain-fatty-acid--CoA ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( BUCS1 ) or ( FACL3 ) or ( FACL5 ) or ( FACL6 ) or ( FACL1 ) or ( FACL4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( long chain fatty acid CoA ligase ) or ( acetyl-coenzyme A synthetase 3 ) or ( long-chain-fatty-acid--CoA ligase 3 ) or ( long-chain-fatty-acid--CoA ligase 5 ) or ( fatty-acid-Coenzyme A ligase, long-chain 6 ) or ( long-chain-fatty-acid--CoA ligase 2 ) or ( long-chain-fatty-acid--CoA ligase 4 )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 6.2.1.3</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUTP__45__PYROP__45__RXN" name="dUTP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DUT ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyuridine 5&apos;-triphosphate nucleotidohydrolase, mitochondrial precursor ) or ( deoxyuridine 5&apos; triphosphate nucleotidohydrolase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__ARGININE__45__DEIMINASE__45__RXN" name="Protein-arginine deiminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PADI4 ) or ( PADI1 ) or ( NA ) or ( PADI2 ) or ( PADI3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein-arginine deiminase type V ) or ( protein-arginine deiminase type I ) or ( arginine deiminase type ) or ( protein-arginine deiminase type II ) or ( protein-arginine deiminase type III )</html:p>
<html:p>SUBSYSTEM: protein citrullination</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.15</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__L__45__Arginines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLMETHIONINE__45__DEFORMYLASE__45__RXN" name="Formylmethionine deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( COG8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptide deformylase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__FORMYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="MET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMARYLACETOACETASE__45__RXN" name="Fumarylacetoacetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarylacetoacetase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: _3__45__KETOBUTYRATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__FUMARYL__45__ACETOACETATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSYLHOMOCYSTEINASE__45__RXN" name="Adenosylhomocysteinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AHCY ) or ( NA ) or ( AHCYL1 ) or ( NA ) or ( KIAA0828 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenosylhomocysteinase ) or ( adenosylhomocysteinase ) or ( putative adenosylhomocysteinase 2 ) or ( adenosylhomocysteinase ) or ( putative adenosylhomocysteinase 3 ) or ( adenosylhomocysteinase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: methionine degradation I (to homocysteine)</html:p>
<html:p>SUBSYSTEM: S-adenosyl-L-methionine cycle</html:p>
<html:p>PROTEIN_CLASS: 3.3.1.1</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADENOSINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__99__46__38__45__RXN" name="Cholesterol 25-hydroxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CH25H )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CHOLESTEROL 25-HYDROXYLASE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.38</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7241" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASNSYNB__45__RXN" name="asparagine synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASNS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparagine synthetase (glutamine-hydrolyzing) )</html:p>
<html:p>SUBSYSTEM: asparagine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.4</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYLSEROTONIN__45__O__45__METHYLTRANSFERASE__45__RXN" name="Acetylserotonin O-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyindole O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.4</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__SEROTONIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__5__45__METHOXY__45__TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEXOKINASE__45__RXN" name="Hexokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GCKR ) or ( HK3 ) or ( FLJ22761 ) or ( NA ) or ( GCK ) or ( HK2 ) or ( HK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucokinase regulatory protein ) or ( hexokinase type III ) or ( hexokinase ) or ( hexokinase ) or ( hexokinase D ) or ( hexokinase, type II ) or ( hexokinase, type I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Hexoses__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__HEXOSE__45__6__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__821" name="Proline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PRODH ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( proline oxidase, mitochondrial precursor ) or ( proline oxidase mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: proline degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: proline degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.8</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRO" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLESTEROL__45__7__45__ALPHA__45__MONOOXYGENASE__45__RXN" name="Cholesterol 7-&amp;alpha;-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP7A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 7A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.17</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__266" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTDECARBOX__45__RXN" name="Glutamate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GAD2 ) or ( NA ) or ( GAD1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamate decarboxylase, 65 kDa isoform ) or ( glutamate decarboxylase kDa ) or ( glutamate decarboxylase, 67 kDa isoform ) or ( glutamate decarboxylase kDa )</html:p>
<html:p>SUBSYSTEM: glutamate dependent acid resistance</html:p>
<html:p>SUBSYSTEM: glutamate degradation IX (via 4-aminobutyrate)</html:p>
<html:p>SUBSYSTEM: glutamate degradation III (via 4-aminobutyrate)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.15</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOKIN__45__RXN" name="Glucokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GCK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexokinase D )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: trehalose degradation II (trehalase)</html:p>
<html:p>SUBSYSTEM: trehalose degradation V</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="ribose-phosphate diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( PRPS1 ) or ( PRPSAP1 ) or ( PRPSAP2 ) or ( PRPS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribose-phosphate pyrophosphokinase III ) or ( ribose-phosphate pyrophosphokinase i ) or ( phosphoribosyl pyrophosphate synthetase-associated protein 1 ) or ( phosphoribosyl pyrophosphate synthetase-associated protein 2 ) or ( ribose-phosphate pyrophosphokinase II )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR24 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 24-dehydrocholesterol reductase precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.72</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8606" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHA__45__L__45__FUCOSIDASE__45__RXN" name="&amp;alpha;-L-fucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MGC1314 ) or ( FUCA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tissue alpha l fucosidase precursor ) or ( tissue alpha-l-fucosidase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.51</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AN__45__ALPHA__45__L__45__FUCOSIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="L__45__FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__11" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 51 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8606" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8607" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__12" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 51 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8607" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8608" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MEPROPCOA__45__FAD__45__RXN" name="2-methylacyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACADSB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ACYL-COA DEHYDROGENASE, SHORT/BRANCHED CHAIN SPECIFIC, MITOCHONDRIAL PRECURSOR )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.12</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__13" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 51 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8608" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__8609" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__14" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TM7SF2 ) or ( LBR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta(14)-sterol reductase ) or ( lamin B receptor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8610" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__10__45__RXN" name="Neolactotetraosylceramide &amp;alpha;-2,3-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SIAT8B ) or ( SIAT8E ) or ( SIAT8D ) or ( SIAT8C ) or ( SIAT8C )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-2,8-sialyltransferase 8B ) or ( alpha-2,8-sialyltransferase 8E ) or ( CMP-N-acetylneuraminate-poly-alpha-2,8-sialyl transferase ) or ( Sia-alpha-2,3-gal-beta-1,4-glcnac-r:alpha 2,8-sialyltransferase ) or ( Sia-alpha-2,3-gal-beta-1,4-glcnac-r:alpha 2,8-sialyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.10</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSYLCERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLNEURAMINYL__45__23__45__BETA__45__D__45__GALACTOSYL__45__ET" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__15" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8610" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8611" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__16" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8611" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8612" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__17" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8612" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__18" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( H105E3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P)-dependent steroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8613" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8614" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__19" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD17B7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( estradiol 17 beta-dehydrogenase 7 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8614" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4184" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__382" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( XYLB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylulokinase homolog )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1093" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYXYLULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__385" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NUDT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__PHOSPHATE__45__KINASE__45__RXN" name="Nucleoside-phosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UMPK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine-cytidine kinase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.4</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NUCLEOSIDE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__45__45__RXN" name="CMP-N-acetylneuraminate monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CMAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTIDINE MONOPHOSPHATE-N-ACETYLNEURAMINIC ACID HYDROXYLASE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP__45__N__45__ACETYL__45__NEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__262" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLESTERASE__45__RXN" name="Arylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PON1 ) or ( PON2 ) or ( PON3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serum paraoxonase/arylesterase 1 ) or ( serum paraoxonase/arylesterase 2 ) or ( serum paraoxonase/arylesterase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phenyl__45__Acetates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__Aryl__45__Alcohol__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4721" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4612" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETAGALACTOSID__45__RXN" name="&amp;beta;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MGC10771 ) or ( NA ) or ( FLJ90231 ) or ( GLB1 ) or ( LOC89944 ) or ( LGALS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-galactosidase precursor ) or ( beta-galactosidase precursor ) or ( beta-galactosidase precursor ) or ( beta-galactosidase precursor ) or ( beta-galactosidase precursor ) or ( GALECTIN-1 )</html:p>
<html:p>SUBSYSTEM: lactose degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__4__46__10__45__RXN" name="Nucleoside-triphosphate--adenylate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AK3 ) or ( AK3 ) or ( AK3 ) or ( AK3L1 ) or ( AK3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylate kinase isoenzyme 4, mitochondrial ) or ( adenylate kinase isoenzyme 4, mitochondrial ) or ( adenylate kinase isoenzyme 4, mitochondrial ) or ( GTP:AMP phosphotransferase mitochondrial ) or ( adenylate kinase isoenzyme 4, mitochondrial )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.10</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Nucleoside__45__Triphosphates__124__" stoichiometry="1"/>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Nucleoside__45__Diphosphates__124__" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9139" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9649" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9138" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="CPD__45__9610" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3341" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PGD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconate dehydrogenase, decarboxylating )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.44</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBULOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4729" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4604" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4607" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4728" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4209" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4603" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4727" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4209" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4602" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LEUKOTRIENE__45__A4__45__HYDROLASE__45__RXN" name="Leukotriene-A4 hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LTA4H )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( leukotriene A-4 hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8892" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6Z8E10E14Z__45__5S12R__45__512__45__DIHYDROXYI" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4726" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__332" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4617" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4725" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__332" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4616" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4724" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__332" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4615" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4723" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.203</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4614" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4722" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4210" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4613" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__20" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4184" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8617" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KETOACYLCOATHIOL__45__RXN" name="Acetyl-CoA C-acyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HADHB ) or ( ACAA1 ) or ( ACAA2 ) or ( ACAA1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional enzyme beta subunit, mitochondrial precursor ) or ( 3-ketoacyl-CoA thiolase, peroxisomal precursor ) or ( 3-ketoacyl-CoA thiolase, mitochondrial ) or ( 3-ketoacyl-CoA thiolase, peroxisomal precursor )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.16</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__KETOACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__OXIDASE__45__RXN" name="Aldehyde oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AOX2 ) or ( AOX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde oxidase 2 ) or ( aldehyde oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__23" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( H105E3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD(P)-dependent steroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.170</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8619" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8620" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOKIN__45__RXN" name="Ribokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RBSK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ribokinase )</html:p>
<html:p>SUBSYSTEM: ribose degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.15</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__24" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD17B7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( estradiol 17 beta-dehydrogenase 7 )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.270</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8620" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8621" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__21" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8617" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC4MOL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C-4 methyl sterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.72</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8618" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8619" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__27" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8646" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DESMOSTEROL__45__CPD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ESTRADIOL__45__17__45__BETA__45__DEHYDROGENASE__45__RXN" name="Estradiol 17 &amp;beta;-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HSD17B2 ) or ( HSD17B3 ) or ( HSD17B1 ) or ( HSD17B7 ) or ( HSD17B4 ) or ( HSD17B8 ) or ( NA ) or ( FLJ14431 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( estradiol 17 beta-dehydrogenase 2 ) or ( estradiol 17 beta-dehydrogenase 3 ) or ( estradiol 17 beta-dehydrogenase 1 ) or ( estradiol 17 beta-dehydrogenase 7 ) or ( estradiol 17 beta-dehydrogenase 4 ) or ( estradiol 17 beta-dehydrogenase 8 ) or ( 17-beta-hydroxysteroid dehydrogenase type VII isoform ) or ( estradiol 17 beta dehydrogenase 8 ) or ( 17-beta-hydroxysteroid dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.62</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__352" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ESTRONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__28" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR24 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 24-dehydrocholesterol reductase precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.72</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DESMOSTEROL__45__CPD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__68__45__RXN" name="1-phosphatidylinositol-4-phosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MGC40423 ) or ( PIP5K2A ) or ( PIP5K1A ) or ( PIP5K2B ) or ( PIP5K1B ) or ( NA ) or ( MGC26597 ) or ( PIK4CA ) or ( NA ) or ( FLJ22055 ) or ( PIP5K1C )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FYVE finger-containing phosphoinositide kinase (fragment) ) or ( phosphatidylinositol-4-phosphate 5-kinase type II alpha ) or ( phosphatidylinositol-4-phosphate 5-kinase, type i, alpha ) or ( phosphatidylinositol-4-phosphate 5-kinase type II beta isoform A ) or ( phosphatidylinositol-4-phosphate 5-kinase, type i, beta ) or ( phosphatidylinositol 4 phosphate 5 kinase ) or ( phosphatidylinositol 4 phosphate 5 kinase ) or ( phosphatidylinositol 4-kinase, catalytic, alpha polypeptide isoform 1 ) or ( phosphatidylinositol 4 phosphate 5 kinase ) or ( phosphatidylinositol 4 phosphate 5 kinase type II alpha ) or ( phosphatidylinositol 4 phosphate 5 kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.68</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1108" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__25" name="Cholestenol &amp;delta;-isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( EBP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>PROTEIN_CLASS: 5.3.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8621" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4186" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__92__45__RXN" name="(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GALGT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-1,4 N-acetylgalactosaminyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.92</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7181" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1100" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__26" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC5DL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lathosterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.6</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__ALPHA__45__CHOLESTA__45__724__45__DIEN__45__3__45__BETA__45__OL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8646" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__29" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OGT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLYPEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__10156" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KERATAN__45__SULFOTRANSFERASE__45__RXN" name="Keratan sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHST2 ) or ( CHST1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 ) or ( carbohydrate (keratan sulfate gal-6) sulfotransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.21</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="KERATAN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="KERATAN__45__6__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROSTAGLANDIN__45__E__45__SYNTHASE__45__RXN" name="Prostaglandin-E synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PTGES )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostaglandin E synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROSTAGLANDIN__45__H2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__15S__45__11__45__ALPHA15__45__DIHYDROXY__45__9__45__O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__7__45__RXN" name="Kynurenine--oxoglutarate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( KATII )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-kynurenine/alpha-aminoadipate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.7</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__476" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TKTL1 ) or ( TKT ) or ( DKFZP434L1717 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase-like 1 ) or ( transketolase ) or ( transketolase )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__KIN__45__RXN" name="NAD(+) kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ13052 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative inorganic polyphosphate/ATP-NAD kinase )</html:p>
<html:p>SUBSYSTEM: NAD/NADH phosphorylation and dephosphorylation</html:p>
<html:p>SUBSYSTEM: NAD phosphorylation and dephosphorylation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.23</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__IDITOL__45__2__45__DEHYDROGENASE__45__RXN" name="L-iditol 2-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SORD ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol dehydrogenase ) or ( sorbitol dehydrogenase ) or ( sorbitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__369" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9569" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDLIPSUCCTRANS__45__RXN" name="Dihydrolipoamide S-succinyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( DLST )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-ketoglutarate dehydrogenase complex dihydrolipoyl succinyltransferase ) or ( dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.61</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: DIHYDROLIPOAMIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD0__45__341" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Quinones__124___TO___124__Reduced__45__Quinones__124___COF_RXN" name="|Quinones|_TO_|Reduced-Quinones|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Reduced__45__Quinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__TYROSINE__45__PHOSPHATASE__45__RXN" name="Protein-tyrosine-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DUSP3 ) or ( PTPRU ) or ( DUSP21 ) or ( PTPN18 ) or ( CDKN3 ) or ( PTPN3 ) or ( TENC1 ) or ( NA ) or ( PTPRT ) or ( DUSP8 ) or ( DUSP18 ) or ( MTMR6 ) or ( TPTE ) or ( PTPRH ) or ( PTPN1 ) or ( PPFIA1 ) or ( TPIP ) or ( PTPN4 ) or ( NA ) or ( NA ) or ( PTPN6 ) or ( PTPRJ ) or ( MGC1136 ) or ( PTPRO ) or ( NA ) or ( MGC35285 ) or ( NA ) or ( PTPN5 ) or ( PTPN5 ) or ( PTPRG ) or ( DKFZP566K0524 ) or ( DUSP7 ) or ( CDC25A ) or ( NA ) or ( MTM1 ) or ( DUSP5 ) or ( NA ) or ( DUSP14 ) or ( DUSP1 ) or ( DUSP12 ) or ( PTPN7 ) or ( PTPRZ1 ) or ( MTMR7 ) or ( PTPRK ) or ( DUSP9 ) or ( NA ) or ( PTPN12 ) or ( DUSP15 ) or ( NA ) or ( PTEN ) or ( PTP4A1 ) or ( PTPNS1 ) or ( PTPRF ) or ( NA ) or ( PTPRN ) or ( PTPN9 ) or ( NA ) or ( DUSP13 ) or ( NA ) or ( PTPRCAP ) or ( DUSP2 ) or ( PTPRS ) or ( PTPRN2 ) or ( PTPRB ) or ( PTPRZ1 ) or ( DUSP10 ) or ( DUSP19 ) or ( CDC25C ) or ( PTP4A3 ) or ( PTPN2 ) or ( NA ) or ( NA ) or ( DUSP4 ) or ( PTPN21 ) or ( DUSP16 ) or ( PTP9Q22 ) or ( EPM2A ) or ( PTPN6 ) or ( PPFIA3 ) or ( PPFIA4 ) or ( CDC25B ) or ( NA ) or ( PTPN13 ) or ( PTPN22 ) or ( PTPN23 ) or ( ACP1 ) or ( PTPN11 ) or ( PTPRR ) or ( PTPRC ) or ( DUSP11 ) or ( PTPN14 ) or ( PTPRA ) or ( DUSP6 ) or ( PTPRE ) or ( PTPRM ) or ( NA ) or ( PTPRD ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dual specificity protein phosphatase 3 ) or ( protein-tyrosine phosphatase U precursor ) or ( dual specificity phosphatase ) or ( protein-tyrosine phosphatase, non-receptor type 18 ) or ( cyclin-dependent kinase inhibitor 3 ) or ( protein tyrosine phosphatase, non-receptor type 3 ) or ( C1 domain-containing phosphatase and tensin-like protein isoform 2 ) or ( tyrosine phosphatase ) or ( protein tyrosine phosphatase, receptor type, T isoform 2 precursor ) or ( dual specificity phosphatase 8 ) or ( dual specificity phosphatase ) or ( myotubularin related protein 6 (fragment) ) or ( putative protein-tyrosine phosphatase TPTE ) or ( protein tyrosine phosphatase, receptor type, H precursor ) or ( protein-tyrosine phosphatase, non-receptor type 1 ) or ( protein tyrosine phosphatase, receptor type, F polypeptide (PTPRF), interacting protein (liprin), alpha 1 ) or ( similar to putative protein-tyrosine phosphatase TPTE (h. sapiens) ) or ( protein tyrosine phosphatase, non-receptor type 4 ) or ( tyrosine phosphatase TPTE ) or ( tyrosine phosphatase precursor R-PTP ) or ( protein-tyrosine phosphatase, non-receptor type 6 ) or ( protein-tyrosine phosphatase eta precursor ) or ( dual specificity phosphatase ) or ( receptor-type protein tyrosine phosphatase O isoform B precursor ) or ( tyrosine phosphatase ) or ( similar to tyrosine phosphatase homolog 1 human ) or ( tyrosine phosphatase TPTE ) or ( protein-tyrosine phosphatase, non-receptor type 5 ) or ( protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) ) or ( protein-tyrosine phosphatase gamma precursor ) or ( similar to tyrosine phosphatase homolog 1 human//tyrosine phosphatase ) or ( dual specificity protein phosphatase 7 ) or ( M-phase inducer phosphatase 1 ) or ( tyrosine phosphatase ) or ( myotubularin ) or ( dual specificity protein phosphatase 5 ) or ( tyrosine phosphatase ) or ( dual specificity protein phosphatase 14 ) or ( dual specificity protein phosphatase 1 ) or ( dual specificity protein phosphatase 12 ) or ( protein-tyrosine phosphatase, non-receptor type 7 ) or ( protein-tyrosine phosphatase zeta precursor ) or ( myotubularin related protein 7 (fragment) ) or ( protein-tyrosine phosphatase kappa precursor ) or ( dual specificity protein phosphatase 9 ) or ( dual specificity phosphatase ) or ( protein-tyrosine phosphatase, non-receptor type 12 ) or ( dual specificity protein phosphatase 15 ) or ( dual specificity phosphatase ) or ( protein-tyrosine phosphatase PTEN ) or ( protein tyrosine phosphatase type IVA, member 1 ) or ( protein tyrosine phosphatase, non-receptor type substrate 1 precursor ) or ( LAR protein precursor ) or ( tyrosine phosphatase ) or ( protein-tyrosine phosphatase-like N precursor ) or ( protein-tyrosine phosphatase, non-receptor type 9 ) or ( tyrosine phosphatase ) or ( dual specificity protein phosphatase 13 ) or ( tyrosine phosphatase ) or ( protein tyrosine phosphatase receptor type C-associated protein ) or ( dual specificity protein phosphatase 2 ) or ( protein tyrosine phosphatase, receptor type, sigma, isoform 1 precursor ) or ( protein tyrosine phosphatase, receptor type, N polypeptide 2 isoform 1 precursor ) or ( protein-tyrosine phosphatase beta precursor ) or ( protein-tyrosine phosphatase zeta precursor ) or ( dual specificity protein phosphatase 10 ) or ( protein phosphatase SKRP1 ) or ( M-phase inducer phosphatase 3 ) or ( protein tyrosine phosphatase type IVA, member 3 isoform 2 ) or ( protein-tyrosine phosphatase, non-receptor type 2 ) or ( protein tyrosine phosphatase RQ (fragment) ) or ( similar to tyrosine phosphatase homolog 1 human ) or ( dual specificity protein phosphatase 4 ) or ( protein tyrosine phosphatase, non-receptor type 21 ) or ( dual specificity protein phosphatase 16 ) or ( protein tyrosine phosphatase PTP9Q22 ) or ( epilepsy, progressive myoclonus type 2, Lafora disease ) or ( protein-tyrosine phosphatase, non-receptor type 6 ) or ( liprin alpha ) or ( liprin-alpha4 (fragment) ) or ( M-phase inducer phosphatase 2 ) or ( tyrosine phosphatase ) or ( protein tyrosine phosphatase, non-receptor type 13 ) or ( protein-tyrosine phosphatase, non-receptor type 22 ) or ( protein tyrosine phosphatase, non-receptor type 23 ) or ( red cell acid phosphatase 1, isozyme F ) or ( protein-tyrosine phosphatase, non-receptor type 11 ) or ( protein-tyrosine phosphatase R precursor ) or ( leukocyte common antigen precursor ) or ( dual specificity protein phosphatase 11 ) or ( protein tyrosine phosphatase, non-receptor type 14 ) or ( vacuolar protein sorting 16 ) or ( dual specificity protein phosphatase 6 ) or ( protein-tyrosine phosphatase epsilon precursor ) or ( protein tyrosine phosphatase, receptor type, M precursor ) or ( dual specificity phosphatase ) or ( protein-tyrosine phosphatase delta precursor ) or ( tyrosine phosphatase non-receptor type 13 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.48</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSE__45__6__45__PHOSPHATE__45__1__45__EPIMERASE__45__RXN" name="Glucose-6 phosphate 1-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>SUBSYSTEM: trehalose degradation V</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.15</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__155__45__RXN" name="&amp;alpha;-1,3(6)-mannosylglycoprotein &amp;beta;-1,6-N-acetyl- glucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MGAT5 ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V ) or ( alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V ) or ( alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.155</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6__45__2__45__N__45__ACETYL__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6__45__26__45__BISN__45__ACETYL__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__3__45__RXN" name="Glucan 1,4-&amp;alpha;-glucosidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GAA ) or ( MGAM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysosomal alpha-glucosidase precursor ) or ( maltase-glucoamylase, intestinal//maltase//glucoamylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMIDINESYN__45__RXN" name="Spermidine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SRM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermidine synthase )</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.16</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANS__45__OCTAPRENYLTRANSTRANSFERASE__45__RXN" name="Trans-octaprenyltranstransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.11</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SOLANESYL__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IODIDE__45__PEROXIDASE__45__RXN" name="Iodide peroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thyroid peroxidase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.11.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__387" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IODINE__45__MOLECULE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__3__45__RXN" name="&amp;alpha;-N-acetylgalactosaminide &amp;alpha;-2,6-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ST6GalNAcI ) or ( STHM ) or ( Siat7c )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase ) or ( alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase II ) or ( alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase III )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.3</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCANO__45__13__45__ETCETERA__45__GLYCOPROTEIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCANO__45__26__45__ETCETERA__45__GLYCOPROTEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__XYLULOSE__45__REDUCTASE__45__RXN" name="D-xylulose reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SORD ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol dehydrogenase ) or ( sorbitol dehydrogenase ) or ( sorbitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.9</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__AMIDINOTRANSFERASE__45__RXN" name="Glycine amidinotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GATM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine amidinotransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: glycine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.4.1</html:p>
<html:p>SIDE: L__45__ORNITHINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
      <speciesReference species="GUANIDOACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__20__45__RXN" name="Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1C4 ) or ( AKR1C2 ) or ( AKR1C1 ) or ( DHDH ) or ( AKR1C3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1 member C4 ) or ( aldo-keto reductase family 1 member C2 ) or ( aldo-keto reductase family 1 member C1 ) or ( dimeric dihydrodiol dehydrogenase ) or ( aldo-keto reductase family 1 member C3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.20</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__289" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__3__46__1__46__43__45__RXN" name="Phosphatidylcholine--sterol O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LCAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylcholine-sterol acyltransferase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.43</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sterols__124__" stoichiometry="1"/>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Steryl__45__Esters__124__" stoichiometry="1"/>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICOTINAMIDE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Nicotinamide N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NNMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinamide N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.1</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__396" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NICONUCADENYLYLTRAN__45__RXN" name="Nicotinate-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( unknown )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.18</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYRIBONUCSYN__45__RXN" name="Phosphoribosylamine--glycine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GART )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional purine biosynthetic protein adenosine-3 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.13</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFATE__45__ADENYLYLTRANS__45__RXN" name="Sulfate adenylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PAPSS2 ) or ( PAPSS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional 3&apos;-phosphoadenosine 5&apos;-phosphosulfate synthethase 2 ) or ( bifunctional 3&apos;-phosphoadenosine 5&apos;-phosphosulfate synthethase 1 )</html:p>
<html:p>SUBSYSTEM: sulfate activation for sulfonation</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.4</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYROXINE__45__DEIODINASE__45__RXN" name="Thyroxine deiodinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DIO3 ) or ( DIO1 ) or ( DIO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thyroxine deiodinase type III ) or ( type I iodothyronine deiodinase ) or ( deiodinase, iodothyronine, type II )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.97.1.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LIOTHYRONINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__387" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__THYROXINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHONDROITIN__45__4__45__SULFOTRANSFERASE__45__RXN" name="Chondroitin 4-sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( C4ST ) or ( C4S-2 ) or ( CHST9 ) or ( C4ST3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( chondroitin 4-sulfotransferase ) or ( chondroitin 4-O-sulfotransferase 2 ) or ( galnac-4-sulfotransferase 2 ) or ( chondroitin 4-O-sulfotransferase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.5</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHONDROITIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHONDROITIN__45__4__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__13__46__11__46__6__45__RXN" name="3-hydroxyanthranilate 3,4-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HAAO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyanthranilate 3,4-dioxygenase )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.6</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__3__45__CARBOXYMUCONATE_SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHAGLYPSYN__45__RXN" name="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PGS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylglycerophosphate synthase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis II</html:p>
<html:p>SUBSYSTEM: cardiolipin biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.5</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLPROLYL__45__ISOMERASE__45__RXN" name="Peptidylprolyl isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FKBP5 ) or ( NA ) or ( NA ) or ( PPIA ) or ( PIN1 ) or ( PIN1L ) or ( NA ) or ( NA ) or ( FKBP6 ) or ( NA ) or ( NA ) or ( PIN4 ) or ( NA ) or ( NA ) or ( PPIL2 ) or ( PPIA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( FKBP11 ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( PPIL3 ) or ( KIAA0073 ) or ( NA ) or ( PPIL5 ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( PPID ) or ( FKBP10 ) or ( NA ) or ( FKBP4 ) or ( NA ) or ( PPIG ) or ( PPIF ) or ( NA ) or ( PPIE ) or ( NA ) or ( NA ) or ( NA ) or ( FKBP9 ) or ( PPIB ) or ( NA ) or ( PPIC ) or ( NA ) or ( NA ) or ( NA ) or ( PPIH ) or ( NA ) or ( FKBP1B ) or ( NA ) or ( PPIL1 ) or ( NA ) or ( NA ) or ( NA ) or ( PPIL4 ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( FKBP7 ) or ( NA ) or ( FKBP14 ) or ( NA ) or ( NA ) or ( FKBP2 ) or ( NA ) or ( FKBP1A ) or ( NA ) or ( NA ) or ( FKBP3 ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( FK506-binding protein 5 ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase A ) or ( peptidyl-prolyl cis-trans isomerase NMA-interacting 1 ) or ( protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1-like ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506-binding protein 6 ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase like 2 ) or ( peptidyl-prolyl cis-trans isomerase A ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506 binding protein 11 precursor ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidylprolyl isomerase-like protein 3 isoform PPIL3a ) or ( KIAA0073 ) or ( peptidyl-prolyl cis-trans isomerase ) or ( 4-1BB mediated signaling molecule ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( 40 kDa peptidyl-prolyl cis-trans isomerase ) or ( FK506 binding protein 10 precursor ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506-binding protein 4 ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl isomerase G ) or ( peptidyl-prolyl cis-trans isomerase, mitochondrial precursor ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase E ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506 binding protein 9 (fragment) ) or ( peptidyl-prolyl cis-trans isomerase B precursor ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase C ) or ( FK506 binding precursor ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506 binding 6 ) or ( peptidyl-prolyl isomerase H ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506-binding protein 1B ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase like 1 ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506 binding ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidylprolyl isomerase (cyclophilin)-like 4 ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506 binding ) or ( FK506-binding protein 7 precursor ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506 binding protein 14 precursor ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506-binding protein 2 precursor ) or ( DJ328E19.1 ) or ( FK506-binding protein 1A ) or ( FK506 binding ) or ( peptidyl-prolyl cis-trans isomerase ) or ( FK506-binding protein 3 ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase ) or ( peptidyl-prolyl cis-trans isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.2.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8624" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8625" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA_TO_CO__45__A_COF_RXN" name="ACYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__AMINOTRANSFERASE__45__RXN" name="Tyrosine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine aminotransferase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.5</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__14__45__RXN" name="Ethanolamine-phosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PCYT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ethanolamine-phosphate cytidylyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.14</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="KYNURENINASE__45__RXN" name="Kynureninase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( KYNU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynureninase )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation I (via anthranilate)</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ANTHRANILATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SQUALENE__45__MONOOXYGENASE__45__RXN" name="Squalene monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SQLE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene monooxygenase )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.7</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__17__45__RXN" name="Phosphatidylethanolamine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PEMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylethanolamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.17</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__405" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1024" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase (NADP+) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.2</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Primary__45__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__121" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GOLPH3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GOLGI PHOSPHOPROTEIN 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="ACET" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONOSYLTRANSFERASE__45__RXN" name="UDP-glucuronosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( UGT1A7 ) or ( NA ) or ( UGT2B15 ) or ( UGT2B17 ) or ( UGT1A3 ) or ( NA ) or ( UGT2B7 ) or ( FLJ21934 ) or ( NA ) or ( NA ) or ( UGT2B4 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A10 ) or ( FLJ34658 ) or ( UGT2B11 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucuronosyltransferase 1 precursor microsomal ) or ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 1 precursor microsomal ) or ( UDP-glucuronosyltransferase 2B15 precursor, microsomal ) or ( UDP-glucuronosyltransferase 2B17 precursor, microsomal ) or ( UDP-glucuronosyltransferase 1-1 precursor, microsomal ) or ( UDP-glucuronosyltransferase 1 precursor microsomal ) or ( UDP-glucuronosyltransferase 2B7 precursor, microsomal ) or ( UDP-glucuronosyltransferase 1 precursor microsomal ) or ( UDP-glucuronosyltransferase ) or ( UDP-glucuronosyltransferase 1 precursor microsomal ) or ( UDP-glucuronosyltransferase 2B4 precursor, microsomal ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP-glucuronosyltransferase 1A9 (fragment) ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP-glucuronosyltransferase 1 precursor microsomal ) or ( UDP-glucuronosyltransferase 2B11 precursor, microsomal ) or ( UDP-glucuronosyltransferase (fragment) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.17</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCURONATE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
      <speciesReference species="__124__Non__45__Glucur__45__Glucuronoside__45__Acceptors__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Beta__45__D__45__Glucuronides__124__" stoichiometry="1"/>
      <speciesReference species="__124__Glucuronosylated__45__Glucuronoside__45__Acceptors__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__2962" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase class III chi chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.284</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__HYDROXYMETHYLGLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__548" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GART__45__RXN" name="Phosphoribosylglycinamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GART )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional purine biosynthetic protein adenosine-3 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.2</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHO__45__RIBOSYL__45__GLYCINEAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__RIBOSYL__45__N__45__FORMYLGLYCINEAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYOSIN__45__LIGHT__45__CHAIN__45__PHOSPHATASE__45__RXN" name="[Myosin light-chain]-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PPP1R12B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein phosphatase 1, regulatory (inhibitor) subunit 12B, isoform A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.53</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8563" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8564" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXY__45__KYNURENINASE__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( KYNU )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( kynureninase )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>PROTEIN_CLASS: 3.7.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__L__45__KYNURENINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ANTHRANILATE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STERYL__45__SULFATASE__45__RXN" name="Steryl-sulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( STS ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( steryl-sulfatase precursor ) or ( steryl sulfatase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__HYDROXYANDROST__45__5__45__EN__45__17__45__ONE__45__3__45__SULFAT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
      <speciesReference species="_3__45__BETA__45__HYDROXYANDROST__45__5__45__EN__45__17__45__ONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__8__45__RXN" name="Dimethylaniline monooxygenase (N-oxide forming)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FMO4 ) or ( FMO5 ) or ( FMO1 ) or ( FMO3 ) or ( LOC116123 ) or ( NA ) or ( NA ) or ( NA ) or ( FMO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dimethylaniline monooxygenase (N-oxide forming) 4 ) or ( dimethylaniline monooxygenase (N-oxide forming) 5 ) or ( dimethylaniline monooxygenase (N-oxide forming) 1 ) or ( dimethylaniline monooxygenase (N-oxide forming) 3 ) or ( dimethylaniline monooxygenase (N oxide forming) ) or ( DJ127D3.2 ) or ( dimethylaniline monooxygenase (N oxide forming) ) or ( dimethylaniline monooxygenase (N oxide forming) ) or ( dimethylaniline monooxygenase (N-oxide forming) 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.8</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NN__45__DIMETHYLANILINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NN__45__DIMETHYLANILINE__45__N__45__OXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GAPOXNPHOSPHN__45__RXN" name="Glyceraldehyde 3-phosphate dehydrogenase (phosphorylating)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( GAPD ) or ( NA ) or ( GAPDS ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyceraldehyde 3 phosphate dehydrogenase ) or ( glyceraldehyde 3 phosphate dehydrogenase ) or ( glyceraldehyde 3 phosphate dehydrogenase ) or ( glyceraldehyde 3 phosphate dehydrogenase ) or ( glyceraldehyde 3 phosphate dehydrogenase ) or ( glyceraldehyde 3 phosphate dehydrogenase ) or ( glyceraldehyde 3-phosphate dehydrogenase, liver ) or ( glyceraldehyde 3 phosphate dehydrogenase ) or ( glyceraldehyde 3-phosphate dehydrogenase, testis-specific ) or ( glyceraldehyde 3 phosphate dehydrogenase ) or ( glyceraldehyde 3 phosphate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FAD_TO_FADH2_COF_RXN" name="FAD_TO_FADH2_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="FAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FADH2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_35__45__CYCLIC__45__GMP__45__PHOSPHODIESTERASE__45__RXN" name="3&apos;,5&apos;-cyclic-GMP phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PDE6A )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( rod cGMP-specific 3&apos;,5&apos;-cyclic phosphodiesterase alpha-subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.35</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CGMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHEAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine aminotransferase )</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__22" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASL ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase ) or ( argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__1__46__96__45__RXN" name="4a-hydroxytetrahydrobiopterin dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PCBD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pterin-4-alpha-carbinolamine dehydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.96</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__4__45__OXO__45__4__45__ALPHA__45__HYDROXY__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__4__45__OXO__45__6__45__123__45__TRIHYDROXYPROP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MONOPHENOL__45__MONOOXYGENASE__45__RXN" name="Monophenol monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TYR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosinase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOPAQUINONE" stoichiometry="1"/>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERPHOSPHA__45__RXN" name="Phosphoserine phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PSPHL ) or ( PSPH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-3-phosphoserine phosphatase homolog ) or ( L-3-phosphoserine phosphatase )</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phosphoserines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Serines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINATE__45__DEHYDROGENASE__45__UBIQUINONE__45__RXN" name="Succinate dehydrogenase (ubiquinone)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( SDHB and SDHC and SDHA and SDHD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate dehydrogenase (ubiquinone) flavoprotein subunit mitochondrial precursor ) or ( SUCCINATE DEHYDROGENASE (UBIQUINONE) IRON-SULFUR PROTEIN, MITOCHONDRIAL PRECURSOR and SUCCINATE DEHYDROGENASE (UBIQUINONE) FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL PRECURSOR and succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor and SUCCINATE DEHYDROGENASE (UBIQUINONE) CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL PRECURSOR )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.3.5.1</html:p>
<html:p>COFACTOR: __124__Ubiquinols__124__</html:p>
<html:p>COFACTOR: __124__Ubiquinones__124__</html:p>
<html:p>SIDE: __124__Ubiquinols__124__</html:p>
<html:p>SIDE: __124__Ubiquinones__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALADENOSYLTRANS__45__RXN" name="Cob(I)alamin adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MMAB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cob(I)alamin adenosyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COB__45__I__45__ALAMIN" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCINATE__45__SEMIALDEHYDE__45__DEHYDROGENASE__45__RXN" name="Succinate-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH5A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate semialdehyde dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation I</html:p>
<html:p>SUBSYSTEM: glutamate degradation III (via 4-aminobutyrate)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.24</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATESYNTH__45__RXN" name="dihydrofolate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FPGS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="_7__45__8__45__DIHYDROPTEROATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16ALDOLASE__45__RXN" name="Fructose-bisphosphate aldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDOB ) or ( NA ) or ( ALDOC ) or ( ALDOA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-bisphosphate aldolase B ) or ( fructose bisphosphate aldolase ) or ( fructose-bisphosphate aldolase C ) or ( fructose-bisphosphate aldolase A )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7607" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NT5C2 ) or ( NT5C1B ) or ( NT5C1A ) or ( NT5E ) or ( NT5M ) or ( NT5C3 ) or ( NT5C ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosolic purine 5&apos;-nucleotidase ) or ( Pan2 protein ) or ( 5&apos;-nucleotidase, cytosolic ia ) or ( 5&apos;-nucleotidase precursor ) or ( 5&apos;,3&apos;-nucleotidase, mitochondrial precursor ) or ( 5&apos;-nucleotidase, cytosolic III ) or ( 5&apos;,3&apos;-nucleotidase, cytosolic ) or ( cytosolic purine 5&apos; nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LONG__45__CHAIN__45__ACYL__45__COA__45__DEHYDROGENASE__45__RXN" name="long-chain acyl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACADL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase, long-chain specific, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.13</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTOACYLASE__45__RXN" name="Aspartoacylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ASPA ) or ( ACY-3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aspartoacylase ) or ( aspartoacylase-3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__576" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7609" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NT5C2 ) or ( NT5C1B ) or ( NT5C1A ) or ( NT5E ) or ( NT5M ) or ( NT5C3 ) or ( NT5C ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosolic purine 5&apos;-nucleotidase ) or ( Pan2 protein ) or ( 5&apos;-nucleotidase, cytosolic ia ) or ( 5&apos;-nucleotidase precursor ) or ( 5&apos;,3&apos;-nucleotidase, mitochondrial precursor ) or ( 5&apos;-nucleotidase, cytosolic III ) or ( 5&apos;,3&apos;-nucleotidase, cytosolic ) or ( cytosolic purine 5&apos; nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1483" name="Ferroxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceruloplasmin precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.16.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FE__43__2" stoichiometry="4"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FE__43__3" stoichiometry="4"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDAZOLONEPROPIONASE__45__RXN" name="Imidazolonepropionase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MGC35366 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( unknown )</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.7</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__IMIDAZOLONE__45__5__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMIMINO__45__L__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPHOSPHOR__45__RXN" name="Guanosine phosphorylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.15</html:p>
<html:p>SIDE: RIBOSE__45__1P</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANINE" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLDIALKYL__45__PHOSPHATASE__45__RXN" name="aryldialkyl phosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PON1 ) or ( PON2 ) or ( PON3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serum paraoxonase/arylesterase 1 ) or ( serum paraoxonase/arylesterase 2 ) or ( serum paraoxonase/arylesterase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="P__45__NITROPHENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__10" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASS ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate synthase ) or ( argininosuccinate synthase ) or ( argininosuccinate synthase ) or ( argininosuccinate synthase ) or ( argininosuccinate synthase ) or ( argininosuccinate synthase ) or ( argininosuccinate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.5</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CANAVANINOSUCCINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXBUTYRYL__45__COA__45__DEHYDRATASE__45__RXN" name="3-hydroxybutyryl-CoA dehydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ECHS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.55</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROGENASE__45__NADPORNOP__43____45__RXN" name="Alcohol dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase (NADP+) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.2</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROTOX__45__RXN" name="Dihydroorotate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DHODH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydroorotate dehydrogenase, mitochondrial precursor (fragment) )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1823" name="&amp;alpha;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( AMY1A ) or ( AMY2A ) or ( AMY1A ) or ( AMY2B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-amylase precursor ) or ( alpha-amylase, salivary precursor ) or ( alpha-amylase, pancreatic precursor ) or ( alpha-amylase, salivary precursor ) or ( alpha-amylase 2B precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Starch__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Large__45__branched__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1825" name="&amp;alpha;-amylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( AMY1A ) or ( AMY2A ) or ( AMY1A ) or ( AMY2B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-amylase precursor ) or ( alpha-amylase, salivary precursor ) or ( alpha-amylase, pancreatic precursor ) or ( alpha-amylase, salivary precursor ) or ( alpha-amylase 2B precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Long__45__linear__45__glucans__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Short__45__glucans__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OHBUTYRYL__45__COA__45__EPIM__45__RXN" name="3-hydroxybutyryl-CoA epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HADHA ) or ( EHHADH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional enzyme alpha subunit, mitochondrial precursor ) or ( peroxisomal bifunctional enzyme )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 5.1.2.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__3__45__HYDROXYACYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRANSALDOL__45__RXN" name="Transaldolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TALDO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transaldolase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="D__45__SEDOHEPTULOSE__45__7__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__CAROTENE__45__1515__45__DIOXYGENASE__45__RXN" name="&amp;beta;-carotene 15,15&apos;-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BCDO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-carotene 15, 15&apos;-dioxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.36</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD1F__45__129" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="RETINAL" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__117__45__RXN" name="Dolichyl-phosphate &amp;beta;-glucosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALG5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dolichyl-phosphate beta-glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.117</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>SIDE: UDP</html:p>
<html:p>SIDE: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__166" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP_TO_GDP_COF_RXN" name="GTP_TO_GDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCSEMIALDDEHYDROG__45__RXN" name="Succinate-semialdehyde dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH1A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 1A1 )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation I</html:p>
<html:p>SUBSYSTEM: glutamate degradation IX (via 4-aminobutyrate)</html:p>
<html:p>SUBSYSTEM: 4-aminobutyrate degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.16</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUCC__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6102" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FPGS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__5725" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__77__45__RXN" name="Protein-L-isoaspartate(D-aspartate) O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PCMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein-l-isoaspartate(D-aspartate) O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.77</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOASPARTATES" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__L__45__BETA__45__ISOSPARTATE__45__METHYL__45__ESTERS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__122__45__RXN" name="Glycoprotein-N-acetylgalactosamine 3-&amp;beta;-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( C1GALT2 ) or ( C1GALT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 2 ) or ( core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.122</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8188" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GALACTOSAMINY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__115__45__RXN" name="[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BCKDK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (3-methyl-2-oxobutanoate dehydrogenase (lipoamide)) kinase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.115</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__3__45__METHYL__45__2__45__OXOBUTANOATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__3__45__METHYL__45__2__45__OXOBUTANOATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93____32__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACYLMANNOSAMINE__45__KINASE__45__RXN" name="N-acylmannosamine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GNE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.60</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1109" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__841" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4731" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4610" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4732" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4609" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4611" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__OXO__45__5__45__BETA__45__STEROID__45__4__45__DEHYDROGENASE__45__RXN" name="3-oxo-5-&amp;beta;-steroid 4-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1D1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxo-5-beta-steroid 4-dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.6</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Oxo__45__5__45__Beta__45__Steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Oxo__45__Delta__45__4__45__Steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4730" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4604" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4608" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOSYLCERAMIDASE__45__RXN" name="Galactosylceramidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GALC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactocerebrosidase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__GALACTOSYLCERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM2__45__RXN" name="Cytidine deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CDA ) or ( AICDA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase ) or ( activation-induced cytidine deaminase )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine ribonucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4737" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4616" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4621" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4144" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TM7SF2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta(14)-sterol reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4081" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4735" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.215</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4620" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4736" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4614" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4622" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4142" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH3B1 ) or ( ALDH3A2 ) or ( ALDH9A1 ) or ( ALDH1A1 ) or ( ALDH3B2 ) or ( NA ) or ( ALDH7A1 ) or ( ALDH1A3 ) or ( ALDH8A1 ) or ( MGC10204 ) or ( ALDH1B1 ) or ( NA ) or ( ALDH3A1 ) or ( ALDH1A2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 7 ) or ( fatty aldehyde dehydrogenase ) or ( aldehyde dehydrogenase, E3 isozyme ) or ( aldehyde dehydrogenase 1A1 ) or ( aldehyde dehydrogenase 8 ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase family 7 member A1 ) or ( aldehyde dehydrogenase 1A3 ) or ( aldehyde dehydrogenase 8A1 isoform 1 ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase x, mitochondrial precursor ) or ( aldehyde dehydrogenase ) or ( aldehyde dehydrogenase, dimeric NADP-preferring ) or ( aldehyde dehydrogenase 1A2 )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;alpha;-oxidation</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4733" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4618" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERILEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BCAT2 ) or ( BCAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase, mitochondrial precursor ) or ( branched-chain amino acid aminotransferase, cytosolic )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ILE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__3__45__METHYL__45__VALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4734" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT1A7 ) or ( UGT2B28 ) or ( NA ) or ( UGT1A5 ) or ( UGT1A10 ) or ( UGT1A9 ) or ( UGT1A4 ) or ( UGT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP glycosyltransferase 1 family, polypeptide A7 ) or ( UDP-glucuronosyltransferase 2B28 precursor, microsomal ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY PROTEIN (FRAGMENT) ) or ( UDP glycosyltransferase 1 family, polypeptide A5 ) or ( UDP glycosyltransferase 1 family, polypeptide A10 ) or ( UDP glycosyltransferase 1 family, polypeptide A9 ) or ( UDP glycosyltransferase 1 family, polypeptide A4 ) or ( UDP GLYCOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE A1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4441" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4619" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREDEHYD__45__RXN" name="Threonine dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SDS-RS1 ) or ( SDS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-serine dehydratase ) or ( L-serine dehydratase )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.19</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIAMIN__45__PYROPHOSPHOKINASE__45__RXN" name="Thiamine pyrophosphokinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiamin pyrophosphokinase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.2</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THIAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THIAMINE__45__PYROPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROTPDECARB__45__RXN" name="Orotidine-5&apos;-phosphate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UMPS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine 5&apos;-monophosphate synthase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.23</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2023" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__THIOURIDINE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__PIPECOLATE__45__OXIDASE__45__RXN" name="L-pipecolate oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PIPOX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal sarcosine oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__PIPECOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROOROT__45__RXN" name="Dihydroorotase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CAD protein )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMYUL__45__L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DI__45__H__45__OROTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROG__45__RXN" name="Glycerol-3-phosphate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( GPD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol 3 phosphate dehydrogenase mitochondrial precursor ) or ( glycerol-3-phosphate dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>SIDE: UBIQUINOL__45__8</html:p>
<html:p>SIDE: UBIQUINONE__45__8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
      <speciesReference species="UBIQUINONE__45__8" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINOL__45__8" stoichiometry="1"/>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERALDEHYDE__45__DEHYDRO__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH7A1 ) or ( ALDH1B1 ) or ( ALDH3A2 ) or ( ALDH9A1 ) or ( ALDH1A1 ) or ( ALDH1A2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family 7 member A1 ) or ( aldehyde dehydrogenase x, mitochondrial precursor ) or ( fatty aldehyde dehydrogenase ) or ( aldehyde dehydrogenase, E3 isozyme ) or ( aldehyde dehydrogenase 1A1 ) or ( aldehyde dehydrogenase 1A2 )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCERALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHD__45__RXN" name="Choline dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CHDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline dehydrogenase )</html:p>
<html:p>SUBSYSTEM: choline degradation I</html:p>
<html:p>SUBSYSTEM: glycine betaine biosynthesis I (Gram-negative bacteria)</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETAINE_ALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLPHOSPHATASE__45__RXN" name="Acylphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACYP1 ) or ( ACYP2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acylphosphatase, organ-common type isozyme ) or ( acylphosphatase, muscle type isozyme )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.7</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acyl__45__Phosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__901" name="Xanthine dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( XDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase ) or ( xanthine dehydrogenase/oxidase//xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>PROTEIN_CLASS: 1.17.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R222__45__RXN" name="Aldehyde dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH7A1 ) or ( ALDH1B1 ) or ( ALDH3A2 ) or ( ALDH9A1 ) or ( ALDH1A1 ) or ( ALDH1A2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase family 7 member A1 ) or ( aldehyde dehydrogenase x, mitochondrial precursor ) or ( fatty aldehyde dehydrogenase ) or ( aldehyde dehydrogenase, E3 isozyme ) or ( aldehyde dehydrogenase 1A1 ) or ( aldehyde dehydrogenase 1A2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.3</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__371" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__195" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOBUTDEHYDROG__45__RXN" name="Aminobutyraldehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH9A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase, E3 isozyme )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine, putrescine, and 4-aminobutyrate degradation</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: putrescine degradation I</html:p>
<html:p>SUBSYSTEM: putrescine degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.19</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_4__45__AMINO__45__BUTYRALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_4__45__AMINO__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__N__45__CHOLOYLTRANSFERASE__45__RXN" name="Glycine N-choloyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BAAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bile acid coenzyme A: amino acid N-acyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.65</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="GLYCOCHOLIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROSTAGLANDIN__45__I__45__SYNTHASE__45__RXN" name="prostaglandin-I synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PTGIS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostacyclin synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROSTAGLANDIN__45__H2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__15S__45__69__45__ALPHA__45__EPOXY__45__11__45__ALPHA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__SYN__45__RXN" name="glutathione synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione synthetase )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: GLY</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7644" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SORD ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sorbitol dehydrogenase ) or ( sorbitol dehydrogenase ) or ( sorbitol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: sorbitol degradation</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.14</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SORBITOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1441" name="ADP-ribose pyrophosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NUDT9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-ribose pyrophosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE_DIPHOSPHATE_RIBOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARYLAMINE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Arylamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NAT2 ) or ( NAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylamine N-acetyltransferase 2 ) or ( arylamine N-acetyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.5</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aryl__45__Amines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYLARYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BISPHOSPHOGLYCERATE__45__PHOSPHATASE__45__RXN" name="Bisphosphoglycerate phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BPGM ) or ( PGAM1 ) or ( NA ) or ( PGAM2 ) or ( PGAM1 ) or ( NA ) or ( NA ) or ( PGAM1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bisphosphoglycerate mutase ) or ( phosphoglycerate mutase 1 ) or ( phosphoglycerate mutase ) or ( phosphoglycerate mutase 2 ) or ( phosphoglycerate mutase 1 ) or ( phosphoglycerate mutase ) or ( phosphoglycerate mutase ) or ( phosphoglycerate mutase 1 ) or ( phosphoglycerate mutase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.13</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_23__45__DIPHOSPHOGLYCERATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__100__45__RXN" name="Protein-S isoprenylcysteine O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ICMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein S-isoprenylcysteine O-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.100</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__ETC__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTEIN__45__C__45__TERMINAL__45__S__45__FARNESYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHENYLALANINE__45__4__45__MONOOXYGENASE__45__RXN" name="Phenylalanine 4-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylalanine-4-hydroxylase )</html:p>
<html:p>SUBSYSTEM: tyrosine biosynthesis II</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.1</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TYR" stoichiometry="1"/>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__4122" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;alpha;-oxidation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2R__45__HYDROPEROXY__45__FATTY__45__ACIDS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Aldehydes__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LANOSTEROL__45__SYNTHASE__45__RXN" name="Lanosterol synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LSS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lanosterol synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LANOSTEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYL__45__COA__45__OXIDASE__45__RXN" name="Acyl-CoA oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ11042 ) or ( ACOX3 ) or ( ACOX1 ) or ( ACOX2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-coenzyme A oxidase peroxisomal ) or ( acyl-coenzyme A oxidase 3, peroxisomal ) or ( acyl-coenzyme A oxidase 1, peroxisomal ) or ( acyl-coenzyme A oxidase 2, peroxisomal )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation II (core pathway)</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.6</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYMIDYLATESYN__45__RXN" name="Thymidylate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TYMS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate synthase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.45</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: DIHYDROFOLATE</html:p>
<html:p>SIDE: DIHYDROFOLATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="XYLULOKIN__45__RXN" name="Xylulokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( XYLB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xylulokinase homolog )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__XYLULOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOESTER__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACATE2 ) or ( PTE1 ) or ( FLJ11106 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PUTATIVE ACYL-COA THIOESTER HYDROLASE CGI-16 ) or ( peroxisomal acyl-coenzyme A thioester hydrolase 1 ) or ( S-acyl fatty acid synthase thioesterase medium chain )</html:p>
<html:p>SUBSYSTEM: acyl-CoA hydrolysis</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.2</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Saturated__45__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NME6 ) or ( NME4 ) or ( NME2 ) or ( NME3 ) or ( NME7 ) or ( NA ) or ( NME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase 6 ) or ( nucleoside diphosphate kinase, mitochondrial precursor ) or ( nucleoside diphosphate kinase B ) or ( nucleoside diphosphate kinase 3 ) or ( nucleoside diphosphate kinase 7 ) or ( putative nucleoside diphosphate kinase ) or ( nucleoside diphosphate kinase A )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BILIVERDIN__45__REDUCTASE__45__RXN" name="Biliverdin reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BLVRA ) or ( BLVRB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biliverdin reductase a precursor ) or ( flavin reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.24</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BILIVERDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIRUBIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DADP_TO_DATP_COF_RXN" name="DADP_TO_DATP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="DADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1401" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MAOA ) or ( MAOB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amine oxidase (flavin-containing) A ) or ( amine oxidase (flavin-containing) B )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VI (via tryptamine)</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.21</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INDOLE_ACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__18__45__RXN" name="[Myosin light-chain] kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( MYLK ) or ( MYLK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myosin light chain kinase ) or ( myosin light chain kinase, smooth muscle and non-muscle isozymes ) or ( myosin light chain kinase 2, skeletal/cardiac muscle )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.18</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8564" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8563" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENOSINE__45__TETRAPHOSPHATASE__45__RXN" name="Adenosine-tetraphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ATP5J )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ATP synthase coupling factor 6, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__607" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROSTAGLANDIN__45__D__45__SYNTHASE__45__RXN" name="Prostaglandin-D synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( PTGDS ) or ( PGDS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostaglandin H2 D-isomerase precursor ) or ( prostaglandin-H2 D-isomerase precursor ) or ( glutathione-requiring prostaglandin D synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.99.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROSTAGLANDIN__45__H2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z13E__45__15S__45__9__45__ALPHA15__45__DIHYDROXY__45__11__45__O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URIDINEKIN__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UCK1 ) or ( UMPK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine-cytidine kinase 1 ) or ( uridine-cytidine kinase 2 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="D__45__AMINO__45__ACID__45__OXIDASE__45__RXN" name="D-amino acid oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DAO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( D-amino acid oxidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__D__45__Amino__45__Acids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__MEBUCOA__45__FAD__45__RXN" name="2-methylacyl-CoA dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACADSB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ACYL-COA DEHYDROGENASE, SHORT/BRANCHED CHAIN SPECIFIC, MITOCHONDRIAL PRECURSOR )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.12</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__METHYL__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDASE__45__YEAST__45__RXN" name="Ceramidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASAH2 ) or ( ASAH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 ) or ( acid ceramidase precursor )</html:p>
<html:p>SUBSYSTEM: sphingolipid metabolism</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.23</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Phytoceramides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="PHYTOSPINGOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7669" name="1,4-&amp;alpha;-glucan branching enzyme" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GBE1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1,4-alpha-glucan branching enzyme )</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis II (from UDP-D-Glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.18</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="POLY__45__GLUCOSYLATED__45__GLYCOGENINS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__6__45__alpha__45__D__45____45__1__45__4__45__alpha__45__D__45__Glucano__45____45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLLACTOSAMINE__45__SYNTHASE__45__RXN" name="N-acetyllactosamine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B4GALT3 ) or ( B4GALT4 ) or ( B4GALT2 ) or ( B4GALT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-1,4-galactosyltransferase 3 ) or ( beta-1,4-galactosyltransferase 4 ) or ( beta-1,4-galactosyltransferase 2 ) or ( beta-1,4-galactosyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.90</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTSEMIALDEHYDROG__45__RXN" name="Glutamate-5-semialdehyde dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PYCS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta 1-pyrroline-5-carboxylate synthetase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.41</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__1461" name="Coproporphyrinogen oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CPO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( coproporphyrinogen III oxidase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>PROTEIN_CLASS: 1.3.3.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COPROPORPHYRINOGEN_III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOPORPHYRINOGEN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__67__45__RXN" name="Quinine 3-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP3A4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 3A4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.67</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUININE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXYQUININE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCINE__45__N__45__ACYLTRANSFERASE__45__RXN" name="Glycine N-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GLYAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycine-N-acyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.13</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__426" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEME__45__OXYGENASE__45__DECYCLIZING__45__RXN" name="Heme oxygenase (decyclizing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HMOX2 ) or ( HMOX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heme oxygenase 2 ) or ( heme oxygenase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.3</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BILIVERDINE" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
      <speciesReference species="CARBON__45__MONOXIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSYLCERAMIDASE__45__RXN" name="Glucosylceramidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GBA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosylceramidase precursor ) or ( glucosylceramidase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.45</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glucosyl__45__Ceramides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__10__46__2__45__RXN" name="Non-specific protein-tyrosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( EPHA8 ) or ( FGFR4 ) or ( LOC51086 ) or ( C20orf64 ) or ( FGFR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ephrin type-A receptor 8 precursor ) or ( fibroblast growth factor receptor 4 precursor ) or ( putative protein-tyrosine kinase ) or ( p53-related protein kinase ) or ( basic fibroblast growth factor receptor 1 precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.10.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFINOALANINE__45__DECARBOXYLASE__45__RXN" name="Sulfinoalanine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CSAD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine sulfinic acid decarboxylase )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation VI</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.29</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HYPOTAURINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSMANMUT__45__RXN" name="Phosphomannomutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PMM1 ) or ( PMM2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomannomutase 1 ) or ( phosphomannomutase 2 )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MANNOSE__45__1P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__34" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ARG2 ) or ( ARG1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arginase II, mitochondrial precursor ) or ( arginase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CANAVANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UREA" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DESULFOHEPARIN__45__SULFOTRANSFERASE__45__RXN" name="Desulfoheparin sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NDST1 ) or ( NDST2 ) or ( NDST4 ) or ( NDST3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( heparan sulfate N-deacetylase/N-sulfotransferase ) or ( heparin sulfate N-deacetylase/N-sulfotransferase ) or ( N-deacetylase/n-sulfotransferase 4 ) or ( N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.8</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__DESULFOHEPARIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEPARIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENPRIBOSYLTRAN__45__RXN" name="Adenine phosphoribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( APRT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of adenine, hypoxanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.7</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENINE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1603" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__409" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__504" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7873" name="&amp;alpha;-1,3-mannosyl-glycoprotein &amp;beta;-1,4-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MGAT4B ) or ( MGAT4A )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B, isoform 1 ) or ( mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.145</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCOSAMINYL__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCOSAMINYL__45__14__45__ETCETERA__45__MANNOSYL__45__R" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANPRIBOSYLTRAN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPRT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hypoxanthine-guanine phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of guanine, xanthine, and their nucleosides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.8</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="GUANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOOHBUTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ILVBL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ILVB (BACTERIAL ACETOLACTATE SYNTHASE)-LIKE )</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis from threonine</html:p>
<html:p>SUBSYSTEM: isoleucine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__2__45__HYDROXY__45__BUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PYRUVATE_TO_L__45__ALPHA__45__ALANINE_COF_RXN" name="PYRUVATE_TO_L-ALPHA-ALANINE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__12__45__RXN" name="cGMP-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PRKG2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cGMP-dependent protein kinase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__6__46__1__46__52__45__RXN" name="Diphosphoinositol-polyphosphate diphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NUDT3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NUDIX (NUCLEOSIDE DIPHOSPHATE LINKED MOIETY X)-TYPE MOTIF 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.52</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Diphospho__45__myo__45__inositol__45__polyphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Myo__45__inositol__45__polyphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBPSYN__45__RXN" name="carbamoyl-phosphate synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CAD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CAD protein )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.5</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FARNESYLTRANSTRANSFERASE__45__RXN" name="geranylgeranyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GGPS1 ) or ( TPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( geranylgeranyl pyrophosphate synthetase ) or ( trans-prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.29</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTOHEMEFERROCHELAT__45__RXN" name="Ferrochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FECH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ferrochelatase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: heme biosynthesis from uroporphyrinogen I</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FE__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOPORPHYRIN_IX" stoichiometry="1"/>
      <speciesReference species="FE__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARAGHYD__45__RXN" name="Asparaginase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASRGL1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( asparaginase-like 1 protein ) or ( L-asparaginase L-asparagine amidohydrolase )</html:p>
<html:p>SUBSYSTEM: superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine.</html:p>
<html:p>SUBSYSTEM: asparagine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ASN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOHMETRANS__45__RXN" name="glycine hydroxymethyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SHMT1 ) or ( STHM ) or ( SHMT1 ) or ( SHMT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase, cytosolic ) or ( alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase II ) or ( serine hydroxymethyltransferase, cytosolic ) or ( serine hydroxymethyltransferase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: serine-isocitrate lyase pathway</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.1</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDE__45__KINASE__45__RXN" name="Ceramide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CERK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceramide kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.138</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__502" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRYPTOPHAN__45__23__45__DIOXYGENASE__45__RXN" name="Tryptophan 2,3-dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TDO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tryptophan 2,3-dioxygenase )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>SUBSYSTEM: tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: tryptophan degradation I (via anthranilate)</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.11</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__FORMYLKYNURENINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTURIDYLYLTRANS__45__RXN" name="UDP-glucose--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GALT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactose-1-phosphate uridylyltransferase )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7800" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7100" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__11__45__RXN" name="cAMP-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PRKACA ) or ( PRKACB ) or ( PRKACG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cAMP-dependent protein kinase, alpha-catalytic subunit ) or ( cAMP-dependent protein kinase, beta-catalytic subunit ) or ( cAMP-dependent protein kinase, gamma-catalytic subunit )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACYLGLUCOSAMINE__45__2__45__EPIMERASE__45__RXN" name="N-acylglucosamine 2-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( RENBP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acylglucosamine 2-epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__270" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__1109" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__22__45__RXN" name="Cyclin-dependent kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( CDK10 ) or ( CDKN2D ) or ( CDC2 ) or ( CDK3 ) or ( NA ) or ( CDK10 ) or ( CDK4 ) or ( CDK5R2 ) or ( CDK5R1 ) or ( CDK6 ) or ( CDK2 ) or ( NA ) or ( CDK5 ) or ( CDKN2A ) or ( NA ) or ( CDK7 ) or ( CDKN2C ) or ( CDKN2B ) or ( CDK8 ) or ( CDK9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYCLIN DEPENDENT KINASE 2 ASSOCIATED 1 CDK2 ASSOCIATED 1 ORAL CANCER SUPPRESSOR DELETED IN ORAL CANCER 1 DOC 1 ) or ( CELL DIVISION PROTEIN KINASE 10 ) or ( CYCLIN-DEPENDENT KINASE 4 INHIBITOR D ) or ( CELL DIVISION CONTROL PROTEIN 2 HOMOLOG ) or ( CELL DIVISION PROTEIN KINASE 3 ) or ( CYCLIN DEPENDENT KINASE 2 ASSOCIATED 1 CDK2 ASSOCIATED 1 ORAL CANCER SUPPRESSOR DELETED IN ORAL CANCER 1 DOC 1 ) or ( cyclin-dependent kinase 10 isoform 3 ) or ( CELL DIVISION PROTEIN KINASE 4 ) or ( CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 2 PRECURSOR ) or ( CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1 PRECURSOR ) or ( CELL DIVISION PROTEIN KINASE 6 ) or ( CELL DIVISION PROTEIN KINASE 2 ) or ( CYCLIN DEPENDENT KINASE 2 ASSOCIATED 1 CDK2 ASSOCIATED 1 ORAL CANCER SUPPRESSOR DELETED IN ORAL CANCER 1 DOC 1 ) or ( CELL DIVISION PROTEIN KINASE 5 ) or ( CYCLIN-DEPENDENT KINASE 4 INHIBITOR A ) or ( CYCLIN DEPENDENT KINASE 2 ASSOCIATED 1 CDK2 ASSOCIATED 1 ORAL CANCER SUPPRESSOR DELETED IN ORAL CANCER 1 DOC 1 ) or ( CELL DIVISION PROTEIN KINASE 7 ) or ( CYCLIN-DEPENDENT KINASE 6 INHIBITOR ) or ( CYCLIN-DEPENDENT KINASE 4 INHIBITOR B ) or ( CELL DIVISION PROTEIN KINASE 8 ) or ( CELL DIVISION PROTEIN KINASE 9 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.22</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__2__45__HYDROXY__45__ACID__45__OXIDASE__45__RXN" name="(S)-2-hydroxy-acid oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HAO1 ) or ( HAO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxyacid oxidase 1 ) or ( hydroxyacid oxidase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.3.15</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__S__45__2__45__Hydroxyacids1__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITDEH__45__RXN" name="Isocitrate dehydrogenase (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IDH2 ) or ( IDH1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor ) or ( isocitrate dehydrogenase (NADP) cytoplasmic ) or ( NADP+-specific isocitrate dehydrogenase (fragment) )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.42</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINESTERASE__45__RXN" name="Cholinesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BCHE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cholinesterase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.8</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Acylcholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PAPS_TO_PAP_COF_RXN" name="PAPS_TO_PAP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="PAPS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1623" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AGPAT2 ) or ( LPAAT-delta ) or ( AGPAT1 ) or ( AGPAT3 ) or ( FLJ11210 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-acyl-sn-glycerol-3-phosphate acyltransferase beta ) or ( 1-acyl-sn-glycerol-3-phosphate acyltransferase delta ) or ( 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha ) or ( 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma ) or ( 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.51</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUCOKINASE__45__RXN" name="Fucokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FUK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-fucose kinase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis II (from L-fucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.52</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__488" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA__45__CARBOXYLTRANSFER__45__RXN" name="Acetyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACACA ) or ( ACACB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acetyl-CoA carboxylase 1 ) or ( acetyl-CoA carboxylase 2 )</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis initiation (E. coli)</html:p>
<html:p>SUBSYSTEM: superpathway of fatty acid biosynthesis I (E. coli)</html:p>
<html:p>SUBSYSTEM: fatty acid biosynthesis initiation I</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HCO3" stoichiometry="1"/>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERVAL__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BCAT2 ) or ( BCAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase, mitochondrial precursor ) or ( branched-chain amino acid aminotransferase, cytosolic )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of alanine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="VAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__ISOVALERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OPPSYN__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRANS__45__POLYISOPRENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOSYLCERAMIDE__45__SULFOTRANSFERASE__45__RXN" name="Galactosylceramide sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( CST )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactosylceramide sulfotransferase ) or ( galactosylceramide sulfotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.11</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="A__45__GALACTOSYLCERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GALACTOSYLCERAMIDE__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__8__46__11__45__RXN" name="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CDIPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CDP-diacylglycerol--inositol 3-phosphatidyltransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.11</html:p>
<html:p>SIDE: MYO__45__INOSITOL</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARNITINE__45__O__45__PALMITOYLTRANSFERASE__45__RXN" name="Carnitine O-palmitoyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHKL ) or ( CPT1A ) or ( CPT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine O-palmitoyltransferase I, mitochondrial muscle isoform ) or ( carnitine O-palmitoyltransferase I, mitochondrial liver isoform ) or ( carnitine O-palmitoyltransferase II, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.21</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: PALMITYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARNITINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__419" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__GLUCURONID__45__RXN" name="&amp;beta;-glucuronidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( GUSB ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( SIMILAR TO GLUCURONIDASE, BETA ) or ( beta-glucuronidase precursor ) or ( beta-glucuronidase precursor ) or ( beta-glucuronidase precursor ) or ( beta-glucuronidase precursor ) or ( beta-glucuronidase precursor ) or ( beta-glucuronidase precursor ) or ( beta-glucuronidase precursor ) or ( beta-glucuronidase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.31</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Beta__45__D__45__Glucuronides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUCURONATE" stoichiometry="1"/>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRATE__45__DEHYDROGENASE__45__RXN" name="3-hydroxyisobutyrate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIBADH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.31</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__7__45__RXN" name="(&amp;alpha;-N-acetyl-neuraminyl-2,3-&amp;beta;-galactosyl-1,3)-N- acetylgalactosaminide &amp;alpha;-2,6-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SIAT7D ) or ( SIAT7E )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N- acetylgalactosaminide alpha-2,6-sialyltransferase ) or ( alpha--acetylgalactosaminide alpha-2,6-sialyltransferase V )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.7</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__ETCETERA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__DIACETYLNEURAMINYL__45__23__45__BETA__45__D__45__ETC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GALACTOSIDE__45__2__45__L__45__FUCOSYLTRANSFERASE__45__RXN" name="Galactoside 2-L-fucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FUT2 ) or ( FUT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactoside 2-l-fucosyltransferase 2 ) or ( galactoside 2-l-fucosyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.69</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__R" stoichiometry="1"/>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__L__45__FUCOSYL__45__12__45__BETA__45__D__45__GALACTOSYL__45__R" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLMALONYL__45__COA__45__MUT__45__RXN" name="Methylmalonyl-CoA mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MUT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonyl-CoA mutase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LCYSDESULF__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CTH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine gamma-lyase )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOXYLATE__45__REDUCTASE__45__NADP__43____45__RXN" name="Glyoxylate reductase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GRHPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxylate reductase/hydroxypyruvate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.79</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__45__45__RXN" name="2-hydroxyacylsphingosine 1-&amp;beta;-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UGT8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.45</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__2__45__HYDROXYACYLSPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__BETA__45__D__45__GALACTOSYL__45__2__45__2__45__HYDROXYACYLS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__11__45__RXN" name="1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PLCD4 ) or ( NA ) or ( PLCG1 ) or ( PLCB1 ) or ( PLCZ1 ) or ( PLCE1 ) or ( PLCG2 ) or ( PLCB2 ) or ( PLCD1 ) or ( PLCB3 ) or ( PLCB4 ) or ( PLCL2 ) or ( PLCL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase C, delta 4 ) or ( 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta ) or ( 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 ) or ( phospholipase C, beta 1 (phosphoinositide-specific) ) or ( phospholipase C, zeta 1 ) or ( pancreas-enriched phospholipase C ) or ( 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 ) or ( 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 ) or ( 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 ) or ( 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 ) or ( 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 ) or ( phospholipase C-like 2 ) or ( phospholipase C-like 1 )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYL__45__MYO__45__INOSITOL__45__45__45__BISPHOSPHA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ISOCITRATE__45__DEHYDROGENASE__45__NAD__43____45__RXN" name="Isocitrate dehydrogenase (NAD+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IDH3B and IDH3G and IDH3A )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ISOCITRATE DEHYDROGENASE (NAD) SUBUNIT BETA, MITOCHONDRIAL PRECURSOR and ISOCITRATE DEHYDROGENASE (NAD) SUBUNIT GAMMA, MITOCHONDRIAL PRECURSOR and ISOCITRATE DEHYDROGENASE (NAD) SUBUNIT ALPHA, MITOCHONDRIAL PRECURSOR )</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.41</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THREO__45__DS__45__ISO__45__CITRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__223__45__RXN" name="Glucuronyl-galactosyl-proteoglycan 4-&amp;alpha;-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( alpha4GnT ) or ( A4GALT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE ) or ( ALPHA-1,4-GALACTOSYLTRANSFERASE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.223</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8622" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8603" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="YEAST__45__SQUALENE__45__RXN" name="Farnesyl-diphosphate farnesyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FDFT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl-diphosphate farnesyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QUINOPRIBOTRANS__45__RXN" name="Nicotinate-nucleotide pyrophosphorylase (carboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( QPRT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nicotinate-nucleotide pyrophosphorylase (carboxylating) )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.19</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: PRPP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="QUINOLINATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NICOTINATE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ETHANOLAMINEPHOSPHOTRANSFERASE__45__RXN" name="Ethanolaminephosphotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CEPT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( choline/ethanolaminephosphotransferase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.1</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CDP__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__36__45__RXN" name="1,2-cyclic-inositol-phosphate phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ANXA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( annexin III )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.43</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__1121" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__P__45__OR__45__NOP_TO_NADH__45__P__45__OR__45__NOP_COF_RXN" name="NAD-P-OR-NOP_TO_NADH-P-OR-NOP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__17__45__RXN" name="L-serine ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SDS-RS1 ) or ( SDS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-serine dehydratase ) or ( L-serine dehydratase )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: L-serine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.17</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDEHYDE__45__REDUCTASE__45__RXN" name="Aldehyde reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1B10 ) or ( AKR1B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ALDO-KETO REDUCTASE FAMILY 1 MEMBER B10 ) or ( aldose reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.21</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALDITOL" stoichiometry="1"/>
      <speciesReference species="__124__Alditols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALDOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PSERTRANSAM__45__RXN" name="Phosphoserine aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PSA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoserine aminotransferase )</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.52</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__SERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__40__45__RXN" name="Glycoprotein-fucosylgalactoside &amp;alpha;-N-acetylgalactosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ABO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( histo-blood group ABO system transferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.40</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__GALACTOSAMINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOPROTEIN__45__ETCETERA__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOPROTEIN__45__ETCETERA__45__GALACTOSAMINYL__45__GAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSGLYPHOS__45__RXN" name="Phosphoglycerate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( PGK1 ) or ( PGK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate kinase ) or ( phosphoglycerate kinase 1 ) or ( phosphoglycerate kinase, testis specific )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DPG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__23__45__RXN" name="Acylglycerol lipase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MGLL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monoglyceride lipase )</html:p>
<html:p>SUBSYSTEM: triacylglycerol degradation</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.23</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Fatty__45__Acids__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__504" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHONDROITIN__45__6__45__SULFOTRANSFERASE__45__RXN" name="Chondroitin 6-sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CHST3 ) or ( CHST2 ) or ( CHST1 ) or ( CHST7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbohydrate (chondroitin 6) sulfotransferase 3 ) or ( carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 ) or ( carbohydrate (keratan sulfate gal-6) sulfotransferase 1 ) or ( carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.17</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHONDROITIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHONDROITIN__45__6__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7835" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DECR2 ) or ( DECR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal 2,4-dienoyl-CoA reductase ) or ( 2,4-dienoyl-CoA reductase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation IV (unsaturated, even number)</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.34</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__trans__45__4__45__cis__45__dienoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Trans__45__3__45__enoyl__45__CoAs__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CTPSYN__45__RXN" name="CTP synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CTPS ) or ( CTPS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CTP synthase ) or ( CTP synthase II )</html:p>
<html:p>SUBSYSTEM: pyrimidine ribonucleotides interconversion</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__45__SYNTH__45__GLN__45__RXN" name="NAD(+) synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ10631 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutamine dependent NAD+ synthetase )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis II (from tryptophan)</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis I (from aspartate)</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde</html:p>
<html:p>SUBSYSTEM: aspartate superpathway</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.1</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEAMIDO__45__NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__5__45__RXN" name="Betaine--homocysteine S-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( BHMT ) or ( BHMT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( betaine--homocysteine S-methyltransferase ) or ( betaine-homocysteine methyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis IV</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="BETAINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MET" stoichiometry="1"/>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THF_TO_METHYLENE__45__THF_COF_RXN" name="THF_TO_METHYLENE-THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FORMYLTHFGLUSYNTH__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FPGS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMYL__45__THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__70__45__RXN" name="Sterol 14-demethylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP51A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 51 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OBTUSIFOLIOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="ALPHA__45__METHYL__45__5__45__ALPHA__45__ERGOSTA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__7001" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( purine nucleoside phosphorylase )</html:p>
<html:p>SUBSYSTEM: arsenate detoxification I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.1</html:p>
<html:p>SIDE: __124__Purine__45__Ribonucleosides__124__</html:p>
<html:p>SIDE: __124__Purine__45__Bases__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARSENATE" stoichiometry="1"/>
      <speciesReference species="__124__Purine__45__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Bases__124__" stoichiometry="1"/>
      <speciesReference species="RIBOSE__45__1__45__ARSENATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FCLEPIM__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TSTA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-fucose synthetase//GDP-mannose-4-keto-6-D epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.-.-.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__L__45__DEOXYGALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5234" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SHMT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLO__45__THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__1__45__RXN" name="Nicotinamide-nucleotide adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NMNAT ) or ( C1orf15 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NMN adenylyltransferase ) or ( nicotinamide mononucleotide adenylyltransferase 2 isoform 2 )</html:p>
<html:p>SUBSYSTEM: NAD biosynthesis III</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway III</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.1</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Acceptor__124___TO___124__Donor__45__H2__124___COF_RXN" name="|Acceptor|_TO_|Donor-H2|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__6__46__1__46__64__45__RXN" name="Glutamine--phenylpyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CCBL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytoplasmic cysteine conjugate-beta lyase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.64</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
      <speciesReference species="_2__45__KETO__45__GLUTARAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMP__45__DEHYDROG__45__RXN" name="IMP dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IMPDH2 ) or ( NA ) or ( NA ) or ( NA ) or ( IMPDH1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inosine-5&apos;-monophosphate dehydrogenase 2 ) or ( inosine 5&apos; monophosphate dehydrogenase 2 ) or ( inosine 5&apos; monophosphate dehydrogenase 2 ) or ( inosine 5&apos; monophosphate dehydrogenase 2 ) or ( inosine-5&apos;-monophosphate dehydrogenase 1 ) or ( inosine 5&apos; monophosphate dehydrogenase 2 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.205</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5240" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SHMT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__47__45__RXN" name="2-acetyl-1-alkylglycerophosphocholine esterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( PAFAH1B2 and PAFAH1B1 and PAFAH1B3 ) or ( PAFAH2 ) or ( PLA2G7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( platelet activating factor acetylhydrolase IB gamma subunit ) or ( PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB GAMMA SUBUNIT and PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB ALPHA SUBUNIT and PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB BETA SUBUNIT ) or ( platelet-activating factor acetylhydrolase 2, cytoplasmic ) or ( platelet-activating factor acetylhydrolase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.47</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alkyl__45__acetyl__45__glycero__45__phosphocholines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="__124__1__45__Alkyl__45__sn__45__glycero__45__3__45__phosphocholines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3PGAREARR__45__RXN" name="Phosphoglycerate mutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PGAM1 ) or ( BPGM ) or ( NA ) or ( PGAM1 ) or ( PGAM2 ) or ( NA ) or ( NA ) or ( NA ) or ( PGAM1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate mutase 1 ) or ( bisphosphoglycerate mutase ) or ( phosphoglycerate mutase ) or ( phosphoglycerate mutase 1 ) or ( phosphoglycerate mutase 2 ) or ( phosphoglycerate mutase ) or ( phosphoglycerate mutase ) or ( DJ834A16.1 (FRAGMENT) ) or ( phosphoglycerate mutase 1 ) or ( phosphoglycerate mutase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: serine-isocitrate lyase pathway</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLNEURAMINATE__45__MONOOXYGENASE__45__RXN" name="CMP-N-acetylneuraminate monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CMAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTIDINE MONOPHOSPHATE-N-ACETYLNEURAMINIC ACID HYDROXYLASE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.18.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYLNEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__273" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URACIL__45__PRIBOSYLTRANS__45__RXN" name="Uracil phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( URKL1 ) or ( MGC23937 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine kinase-like 1 ) or ( ambiguous )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.9</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URACIL" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOPHOSPHORYL__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PYGM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase, muscle form )</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycogens__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
      <speciesReference species="CPD0__45__971" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPERMINE__45__SYNTHASE__45__RXN" name="Spermine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( SMS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( spermine synthase ) or ( spermine synthase )</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis II</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEAMINASE__45__RXN" name="AMP deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AMPD1 ) or ( AMPD3 ) or ( AMPD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( AMP deaminase 1 ) or ( AMP deaminase 3 ) or ( AMP deaminase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="N__45__ACETYLTRANSFER__45__RXN" name="Amino-acid N-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NAGS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglutamate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__GLU" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MANNPISOM__45__RXN" name="Mannose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MPI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mannose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: D-mannose degradation</html:p>
<html:p>SUBSYSTEM: GDP-mannose metabolism</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DCMP__45__DEAMINASE__45__RXN" name="dCMP deaminase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DCTD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxycytidylate deaminase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DCMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__NUCLEOTID__45__RXN" name="5&apos;-nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NT5C2 ) or ( NT5C1B ) or ( NT5C1A ) or ( NT5E ) or ( NT5M ) or ( NT5C3 ) or ( NT5C ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosolic purine 5&apos;-nucleotidase ) or ( Pan2 protein ) or ( 5&apos;-nucleotidase, cytosolic ia ) or ( 5&apos;-nucleotidase precursor ) or ( 5&apos;,3&apos;-nucleotidase, mitochondrial precursor ) or ( 5&apos;-nucleotidase, cytosolic III ) or ( 5&apos;,3&apos;-nucleotidase, cytosolic ) or ( cytosolic purine 5&apos; nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleosides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANIDINOACETATE__45__N__45__METHYLTRANSFERASE__45__RXN" name="Guanidinoacetate N-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GAMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanidinoacetate N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: glycine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.2</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GUANIDOACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CREATINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__11__46__2__45__RXN" name="Procollagen-proline,2-oxoglutarate-4-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( P4HA2 ) or ( NA ) or ( P4HA1 ) or ( P4HB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prolyl 4-hydroxylase alpha-2 subunit precursor ) or ( prolyl 4-hydroxylase alpha subunit ) or ( prolyl 4-hydroxylase alpha-1 subunit precursor ) or ( protein disulfide isomerase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.11.2</html:p>
<html:p>COFACTOR: SUC</html:p>
<html:p>COFACTOR: OXYGEN__45__MOLECULE</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROCOLLAGEN__45__L__45__PROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6321" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADNUCLEOSID__45__RXN" name="NAD(+) nucleosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CD38 ) or ( BST1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ADP-ribosyl cyclase 1 ) or ( ADP-ribosyl cyclase 2 precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of NAD biosynthesis in eukaryotes</html:p>
<html:p>SUBSYSTEM: NAD salvage pathway I</html:p>
<html:p>PROTEIN_CLASS: 3.2.2.5</html:p>
<html:p>SIDE: ADENOSINE_DIPHOSPHATE_RIBOSE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
      <speciesReference species="ADENOSINE_DIPHOSPHATE_RIBOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTATHIONE__45__REDUCT__45__NADPH__45__RXN" name="Glutathione reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GSR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutathione reductase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions II</html:p>
<html:p>SUBSYSTEM: glutathione redox reactions I</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXIDIZED__45__GLUTATHIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTATHIONE" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SHMT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase 2 (mitochondrial) )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOLATE__45__REDUCTASE__45__RXN" name="Glycolate reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GRHPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxylate reductase/hydroxypyruvate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.26</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOLLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPONTPRO__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: proline biosynthesis V (from arginine)</html:p>
<html:p>SUBSYSTEM: proline biosynthesis III</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: arginine degradation VII</html:p>
<html:p>SUBSYSTEM: arginine degradation VI (arginase 2 pathway)</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>SUBSYSTEM: arginine degradation I (arginase pathway)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DELTA1__45__PYRROLINE_5__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNITHINE__45____45__OXO__45__ACID__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine aminotransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Oxo__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE_GAMMA__45__SEMIALDEHYDE" stoichiometry="1"/>
      <speciesReference species="__124__Amino__45__Acids__45__20__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DNA__45__LIGASE__45__NAD__43____45__RXN" name="DNA ligase (NAD+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LIG3 ) or ( LIG1 ) or ( LIG4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DNA ligase III ) or ( DNA ligase I ) or ( DNA ligase IV )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 6.5.1.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
      <speciesReference species="DEOXYNUCLEOTIDESM" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="__124__Deoxynucleotides__124__" stoichiometry="1"/>
      <speciesReference species="NICOTINAMIDE_NUCLEOTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__133__45__RXN" name="Xylosylprotein 4-&amp;beta;-galactosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B4GALT7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-1,4-galactosyltransferase 7 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.133</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GALACTOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8590" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8202" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MEVALONATE__45__KINASE__45__RXN" name="Mevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MVK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( mevalonate kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.36</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MEVALONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIACYLGLYKIN__45__RXN" name="Diacylglycerol kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DGKD ) or ( NA ) or ( DGKA ) or ( DGKB ) or ( DGKZ ) or ( DGKQ ) or ( NA ) or ( DGKG ) or ( DGKH ) or ( DGKI ) or ( DGKE ) or ( NA ) or ( NA ) or ( DKFZp761I1510 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diacylglycerol kinase, delta (fragment) ) or ( diacylglycerol kinase zeta ) or ( diacylglycerol kinase, alpha 80kDa ) or ( diacylglycerol kinase, beta ) or ( diacylglycerol kinase, zeta ) or ( diacylglycerol kinase, theta ) or ( diacylglycerol kinase zeta ) or ( diacylglycerol kinase, gamma ) or ( diacylglycerol kinase, eta ) or ( diacylglycerol kinase, iota ) or ( diacylglycerol kinase, epsilon ) or ( diacylglycerol kinase ) or ( diacylglycerol kinase delta ) or ( diacylglycerol kinase delta )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.107</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45____45__PYRUVATE__45__AMINOTRANSFERASE__45__RXN" name="Serine--pyruvate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AGXT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine--pyruvate aminotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.51</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__3__46__2__46__10__45__RXN" name="Soluble epoxide hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( EPHX2 ) or ( FLJ90341 ) or ( FLJ22408 ) or ( FLJ11743 ) or ( EPHX1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( soluble epoxide hydrolase ) or ( FLJ90341 ) or ( FLJ22408 ) or ( FLJ11743 ) or ( epoxide hydrolase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.3.2.10</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__epoxides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__glycols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THIOSULFATE__45__SULFURTRANSFERASE__45__RXN" name="Thiosulfate sulfurtransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TST )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thiosulfate sulfurtransferase )</html:p>
<html:p>SUBSYSTEM: thiosulfate disproportionation III (rhodanese)</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.1</html:p>
<html:p>SIDE: HCN</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S2O3" stoichiometry="1"/>
      <speciesReference species="HCN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SO3" stoichiometry="1"/>
      <speciesReference species="HSCN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__DEHYDROG__45__GENERIC__45__RXN" name="alcohol dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ADH7 ) or ( ADH8 ) or ( ADH6 ) or ( ADH5 ) or ( ADH4 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol dehydrogenase class IV mu/sigma chain ) or ( alcohol dehydrogenase 8 ) or ( alcohol dehydrogenase 6 ) or ( alcohol dehydrogenase class III chi chain ) or ( alcohol dehydrogenase class II pi chain precursor ) or ( alcohol dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.1</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aldehydes__45__Or__45__Ketones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACID__45__PHOSPHATASE__45__RXN" name="Acid phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ACP2 ) or ( ACPT ) or ( CXCL1 ) or ( ACPP ) or ( ACP1 ) or ( ACP5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysosomal acid phosphatase precursor ) or ( testicular acid phosphatase isoform a precursor ) or ( GROWTH REGULATED PROTEIN PRECURSOR ) or ( prostatic acid phosphatase precursor ) or ( red cell acid phosphatase 1, isozyme F ) or ( tartrate-resistant acid phosphatase type 5 precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.2</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__SYNTHASE__45__RXN" name="Cystathionine &amp;beta;-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CBS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine beta-synthase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis/homocysteine degradation</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__4__45__RXN" name="&amp;beta;-galactoside &amp;alpha;-2,3-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( SIAT4C ) or ( SIAT4B ) or ( SIAT4A )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CMP-N-acetylneuraminate beta-galactosamide alpha 2,3-sialyltransferase ) or ( CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase ) or ( CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase ) or ( CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.4</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GALACTOSAMINY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__ETCETERA__45__GALACT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACNEULY__45__RXN" name="N-acetylneuraminate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( C1orf13 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylneuraminate lyase )</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: N-acetylneuraminate and N-acetylmannosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYLNEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__D__45__MANNOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__152__45__RXN" name="Inositol-hexakisphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( IHPK3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( INOSITOL HEXAPHOSPHATE KINASE 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MI__45__HEXAKISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__DIPHOSPHO__45__1D__45__MYO__45__INOSITOL__45__12346P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__151__45__RXN" name="Inositol-polyphosphate multikinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IMPK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( INOSITOL POLYPHOSPHATE MULTIKINASE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.151</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__5__45__TRISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="INOSITOL__45__1456__45__TETRAKISPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__17__45__RXN" name="3&apos;,5&apos;-cyclic-nucleotide phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PDE4A ) or ( PDE10A ) or ( PDE4C ) or ( PDE1C ) or ( PDE9A ) or ( NA ) or ( PDE8A ) or ( PDE6A and PDE6G and PDE6B ) or ( PDE3B ) or ( PDE4B ) or ( PDE11A ) or ( PDE3A ) or ( PDE2A ) or ( PDE4D ) or ( PDE6C ) or ( PDE7B ) or ( PDE1A ) or ( PDE8B ) or ( PDE1B ) or ( PDE6D ) or ( PDE5A ) or ( PDE7A )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cAMP-specific 3&apos;,5&apos;-cyclic phosphodiesterase 4A ) or ( cAMP and cAMP-inhibited cGMP 3&apos;,5&apos;-cyclic phosphodiesterase 10A ) or ( cAMP-specific 3&apos;,5&apos;-cyclic phosphodiesterase 4C ) or ( calcium/calmodulin-dependent 3&apos;,5&apos;-cyclic nucleotide phosphodiesterase 1C ) or ( high-affinity cGMP-specific 3&apos;,5&apos;-cyclic phosphodiesterase 9A ) or ( 3&apos; 5&apos;-cyclic phosphodiesterase ) or ( high-affinity cAMP-specific and IBMX-insensitive 3&apos;,5&apos;-cyclic phosphodiesterase 8A ) or ( rod cGMP-specific 3&apos;,5&apos;-cyclic phosphodiesterase alpha-subunit and RETINAL CONE RHODOPSIN-SENSITIVE CGMP 3&apos;,5&apos;-CYCLIC PHOSPHODIESTERASE GAMMA-SUBUNIT and ROD CGMP-SPECIFIC 3&apos;,5&apos;-CYCLIC PHOSPHODIESTERASE BETA-SUBUNIT ) or ( cGMP-inhibited 3&apos;,5&apos;-cyclic phosphodiesterase B ) or ( phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila) ) or ( phosphodiesterase 11A ) or ( cGMP-inhibited 3&apos;,5&apos;-cyclic phosphodiesterase A ) or ( cGMP-dependent 3&apos;,5&apos;-cyclic phosphodiesterase ) or ( cAMP-specific 3&apos;,5&apos;-cyclic phosphodiesterase 4D ) or ( cone cGMP-specific 3&apos;,5&apos;-cyclic phosphodiesterase alpha&apos;-subunit ) or ( cAMP-specific 3&apos;,5&apos;-cyclic phosphodiesterase 7B ) or ( calcium/calmodulin-dependent 3&apos;,5&apos;-cyclic nucleotide phosphodiesterase 1A ) or ( high-affinity cAMP-specific and IBMX-insensitive 3&apos;,5&apos;-cyclic phosphodiesterase 8B (fragment) ) or ( calcium/calmodulin-dependent 3&apos;,5&apos;-cyclic nucleotide phosphodiesterase 1B ) or ( retinal rod rhodopsin-sensitive cGMP 3&apos;,5&apos;-cyclic phosphodiesterase delta-subunit ) or ( cGMP-specific 3&apos;,5&apos;-cyclic phosphodiesterase ) or ( high-affinity cAMP-specific 3&apos;,5&apos;-cyclic phosphodiesterase 7A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.17</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__3__45__5__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NUC__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDLIPACETRANS__45__RXN" name="Dihydrolipoamide S-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PDX1 ) or ( DLAT ) or ( DBT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyruvate dehydrogenase protein X component, mitochondrial precursor ) or ( dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor ) or ( lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.12</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ACETYLDIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__OXOPROLINASE__45__ATP__45__HYDROLYSING__45__RXN" name="5-oxoprolinase (ATP-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( OPLAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5-oxoprolinase ) or ( 5-oxoprolinase (ATP-hydrolysing) )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>PROTEIN_CLASS: 3.5.2.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__OXOPROLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AICARTRANSFORM__45__RXN" name="Phosphoribosylaminoimidazolecarboxamide formyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ATIC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( bifunctional purine biosynthesis protein purh )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.3</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>COFACTOR: _10__45__FORMYL__45__THF</html:p>
<html:p>SIDE: THF</html:p>
<html:p>SIDE: _10__45__FORMYL__45__THF</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AICAR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMAMIDO__45__CARBOXAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHYLACYLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( FLJ10948 ) or ( HADHA ) or ( NA ) or ( EHHADH ) or ( ECHS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal bifunctional enzyme PBE PBFE ) or ( unknown ) or ( trifunctional enzyme alpha subunit, mitochondrial precursor ) or ( peroxisomal bifunctional enzyme PBE PBFE ) or ( peroxisomal bifunctional enzyme ) or ( enoyl-CoA hydratase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHACRYLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__57__45__RXN" name="Inositol-1,4-bisphosphate 1-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INPP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( inositol polyphosphate 1-phosphatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.57</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INOSITOL__45__1__45__4__45__BISPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__MYO__45__INOSITOL__45__4__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2TRANSKETO__45__RXN" name="Transketolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TKTL1 ) or ( TKT ) or ( DKFZP434L1717 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( transketolase-like 1 ) or ( transketolase ) or ( transketolase )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (non-oxidative branch)</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XYLULOSE__45__5__45__PHOSPHATE" stoichiometry="1"/>
      <speciesReference species="ERYTHROSE__45__4P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GAP" stoichiometry="1"/>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROID__45__21__45__MONOOXYGENASE__45__RXN" name="Steroid 21-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP21A2 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 XXIB ) or ( cytochrome p450 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__21__45__Hydroxysteroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1685" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GCKR ) or ( HK3 ) or ( FLJ22761 ) or ( NA ) or ( GCK ) or ( HK2 ) or ( HK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucokinase regulatory protein ) or ( hexokinase type III ) or ( hexokinase ) or ( hexokinase ) or ( hexokinase D ) or ( hexokinase, type II ) or ( hexokinase, type I )</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BAIAEUBSP__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( RDHL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent retinol dehydrogenase/reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.-</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__202" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__OXO__45__CHOLYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PDXK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxal kinase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.-</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHYLARGININASE__45__RXN" name="Dimethylargininase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( DDAH2 ) or ( DDAH1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NG,NG-dimethylarginine dimethylaminohydrolase 1 ) or ( NG,NG-dimethylarginine dimethylaminohydrolase 2 ) or ( dimethylarginine dimethylaminohydrolase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.3.18</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__596" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYLAMINE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRROLINEDEH__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH4A1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 4A1 precursor ) or ( delta-1-pyrroline 5 carboxylate dehydrogenase mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: 4-hydroxyproline degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRROLINE__45__HYDROXY__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ERYTHRO__45__4__45__HYDROXY__45__GLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDPGLUCEPIM__45__RXN" name="UDP-glucose 4-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GALE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucose 4-epimerase )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: UDP-glucose conversion</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__8__46__3__46__9__45__RXN" name="Butyrate-acetoacetate CoA-transferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GOLPH3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GOLGI PHOSPHOPROTEIN 3 )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine fermentation to acetate and butyrate</html:p>
<html:p>PROTEIN_CLASS: 2.8.3.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BUTYRYL__45__COA" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETOACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="BUTYRIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__30__45__RXN" name="Fucose-1-phosphate guanylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FPGT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fucose-1-phosphate guanylyltransferase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis II (from L-fucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.30</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__488" stoichiometry="1"/>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__12__46__2__45__RXN" name="Mitogen-activated protein kinase kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MAP2K1IP1 ) or ( MAP2K2 ) or ( MAP2K4 ) or ( MAP2K6 ) or ( MAP2K7 ) or ( MAP2K5 ) or ( MAP2K1 ) or ( MAP2K3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 INTERACTING PROTEIN 1 ) or ( DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 ) or ( DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 ) or ( DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 ) or ( DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7 ) or ( DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 ) or ( DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1 ) or ( DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.12.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALKAPHOSPHA__45__RXN" name="Alkaline phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALPL ) or ( ALPPL2 ) or ( ALPI ) or ( ALPP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alkaline phosphatase, tissue-nonspecific isozyme precursor ) or ( alkaline phosphatase, placental-like precursor ) or ( alkaline phosphatase, intestinal precursor ) or ( alkaline phosphatase, placental type 1 precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Orthophosphoric__45__Monoesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_6PGLUCONOLACT__45__RXN" name="6-phosphogluconolactonase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PGLS ) or ( H6PD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphogluconolactonase ) or ( GDH/6PGL endoplasmic bifunctional protein precursor )</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway</html:p>
<html:p>SUBSYSTEM: pentose phosphate pathway (oxidative branch)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.31</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__6__45__P__45__GLUCONO__45__DELTA__45__LACTONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRNA__45__PSEUDOURIDINE__45__SYNTHASE__45__I__45__RXN" name="tRNA-pseudouridine synthase I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PUS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tRNA pseudouridine synthase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.4.99.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__8538" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8537" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R81__45__RXN" name="Hexokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GCKR ) or ( HK3 ) or ( FLJ22761 ) or ( NA ) or ( GCK ) or ( HK2 ) or ( HK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucokinase regulatory protein ) or ( hexokinase type III ) or ( hexokinase ) or ( hexokinase ) or ( hexokinase D ) or ( hexokinase, type II ) or ( hexokinase, type I )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_ADP_COF_RXN" name="ATP_TO_ADP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLUCISOM__45__RXN" name="Glucose-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GPI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>SUBSYSTEM: GDP-mannose biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__1__46__70__45__RXN" name="&amp;delta;(14)-sterol reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TM7SF2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta(14)-sterol reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.70</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_44__45__DIMETHYL__45__824__45__CHOLESTADIENOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_44__45__DIMETHYL__45__CHOLESTA__45__812__45__24__45__TRIENOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTKIN__45__RXN" name="Glutamate 5-kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PYCS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( delta 1-pyrroline-5-carboxylate synthetase )</html:p>
<html:p>SUBSYSTEM: proline biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>SUBSYSTEM: citrulline biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.2.11</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GLUTAMATE__45__5__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CITSYN__45__RXN" name="Citrate (si)-synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( FLJ40154 ) or ( CS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( condensing enzyme ) or ( condensing enzyme ) or ( citrate synthase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: serine-isocitrate lyase pathway</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.3.3.1</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CIT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THYKI__45__RXN" name="Thymidine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TK1 ) or ( TK2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidine kinase, cytosolic ) or ( thymidine kinase 2, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.21</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="THYMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__241" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PNMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phenylethanolamine N-methyltransferase )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.28</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="NOREPINEPHRINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__EPINEPHRINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8747" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ENPP2 ) or ( PDE1A ) or ( PDE1B ) or ( ENPP3 ) or ( PDE1C ) or ( PDE4DIP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ectonucleotide pyrophosphatase/phosphodiesterase 2//nucleotide pyrophosphatase ) or ( calcium/calmodulin-dependent 3&apos;,5&apos;-cyclic nucleotide phosphodiesterase 1A ) or ( calcium/calmodulin-dependent 3&apos;,5&apos;-cyclic nucleotide phosphodiesterase 1B ) or ( ectonucleotide pyrophosphatase/phosphodiesterase 3//nucleotide pyrophosphatase ) or ( calcium/calmodulin-dependent 3&apos;,5&apos;-cyclic nucleotide phosphodiesterase 1C ) or ( MYOMEGALIN )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIETHYLPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETOH" stoichiometry="1"/>
      <speciesReference species="CPD__45__8978" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Fatty__45__Acyl__45__CoA__124___TO_CO__45__A_COF_RXN" name="|Fatty-Acyl-CoA|_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCOSYLCERAMIDASE__45__RXN" name="Glycosylceramidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( LCT ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lactase phlorizin hydrolase precursor lactase glycosylceramidase//lactase//phlorizin hydrolase ) or ( lactase-phlorizin hydrolase precursor//lactase//phlorizin hydrolase ) or ( lactase phlorizin hydrolase precursor lactase glycosylceramidase//lactase//phlorizin hydrolase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.62</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOSYL__45__N__45__ACYLSPHINGOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
      <speciesReference species="__124__Sugar__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="F16BDEPHOS__45__RXN" name="Fructose-bisphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FBP2 ) or ( FBP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fructose-1,6-bisphosphatase isozyme 2 ) or ( fructose-1,6-bisphosphatase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FRUCTOSE__45__16__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__197__45__RXN" name="15-hydroxyprostaglandin dehydrogenase (NADP+)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CBR1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbonyl reductase (NADPH) 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.197</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPROSTADIL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_13E__45__11__45__ALPHA__45__HYDROXY__45__915__45__DIOXOPROST__45__1" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALCOHOL__45__SULFOTRANSFERASE__45__RXN" name="Alcohol sulfotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SULT2A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alcohol sulfotransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.2</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALKYL__45__SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__20__45__RXN" name="Methylenetetrahydrofolate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MTHFR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylenetetrahydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.20</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CERAMIDE__45__GLUCOSYLTRANSFERASE__45__RXN" name="Ceramide glucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UGCG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ceramide glucosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.80</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Glucosyl__45__Ceramides__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GDPMANDEHYDRA__45__RXN" name="GDP-mannose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GMDS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-mannose 4,6 dehydratase )</html:p>
<html:p>SUBSYSTEM: GDP-L-fucose biosynthesis I (from GDP-D-mannose)</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: GDP-D-rhamnose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.47</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__MANNOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__DEOXY__45__D__45__MANNOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TYROSINE__45__3__45__MONOOXYGENASE__45__RXN" name="Tyrosine 3-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine hydroxylase subunit )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.16.2</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CPD__45__5881</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
      <speciesReference species="TYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__5881" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GUANYLCYC__45__RXN" name="Guanylate cyclase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( GUCY1A2 ) or ( GUCY1B2 ) or ( GUCA1B ) or ( NPR2 ) or ( NPR1 ) or ( GUCY2C ) or ( GUCY2D ) or ( GUCA1A ) or ( GUCA2A ) or ( GUCY2F ) or ( GUCY1A3 ) or ( GUCA2B ) or ( NA ) or ( GUCY1B3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cyclase ) or ( guanylate cyclase soluble, alpha-2 chain ) or ( guanylate cyclase soluble, beta-2 chain ) or ( guanylyl cyclase activating protein 2 ) or ( atrial natriuretic peptide receptor B precursor ) or ( atrial natriuretic peptide receptor A precursor ) or ( heat-stable enterotoxin receptor precursor ) or ( retinal guanylyl cyclase 1 precursor ) or ( guanylyl cyclase activating protein 1 ) or ( guanylin precursor ) or ( retinal guanylyl cyclase 2 precursor ) or ( guanylate cyclase soluble, alpha-3 chain ) or ( uroguanylin precursor ) or ( cyclase ) or ( guanylate cyclase soluble, beta-1 chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.6.1.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CGMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROTEIN__45__KINASE__45__RXN" name="Protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( STK18 ) or ( CSNK1A1 ) or ( ATM ) or ( STK6 ) or ( CSNK1G1 ) or ( PRKACB ) or ( STK17B ) or ( NA ) or ( ACVR2B ) or ( PRKG2 ) or ( PRKCZ ) or ( GAK ) or ( TLK1 ) or ( TGFBR1 ) or ( STK29 ) or ( CKS1B ) or ( CHUK ) or ( CDKL1 ) or ( MARK2 ) or ( CSNK1E ) or ( BMPR2 ) or ( CIT ) or ( CSNK1G2 ) or ( NA ) or ( NA ) or ( NJMU-R1 ) or ( STK22A ) or ( NLK ) or ( LOC149420 ) or ( AKT1 ) or ( ACVRL1 ) or ( STK38L ) or ( STK12 ) or ( IRAK1 ) or ( STK13 ) or ( TLK2 ) or ( NA ) or ( NA ) or ( PRKACG ) or ( STK4 ) or ( NRGN ) or ( PASK ) or ( PRKDC ) or ( NA ) or ( NA ) or ( HAK ) or ( PRKCL1 ) or ( STK11IP ) or ( PAK7 ) or ( NEK1 ) or ( MARK1 ) or ( TOPK ) or ( NA ) or ( NA ) or ( ACVR1 ) or ( NA ) or ( PSKH2 ) or ( ACVR2 ) or ( FLJ25965 ) or ( NEK3 ) or ( ZAK ) or ( NEK2 ) or ( NA ) or ( STK19 ) or ( GSK3B ) or ( STK3 ) or ( KIAA1804 ) or ( CLK1 ) or ( PIM2 ) or ( STK22D ) or ( FASTK ) or ( NA ) or ( NA ) or ( PFTK1 ) or ( CHEK2 ) or ( MAP3K12 ) or ( STK24 ) or ( NA ) or ( PRKCH ) or ( PRKCG ) or ( PAK4 ) or ( CKS2 ) or ( NA ) or ( ULK1 ) or ( CHEK1 ) or ( GSK3A ) or ( CDC2L5 ) or ( STK17A ) or ( CNK ) or ( PRKCQ ) or ( STK23 ) or ( STK35 ) or ( PKIA ) or ( HUNK ) or ( CKS1B ) or ( AKT3 ) or ( MAPK8 ) or ( NEK7 ) or ( MGC33182 ) or ( CSNK2B ) or ( PRKCI ) or ( PCTK1 ) or ( CSNK1D ) or ( CSNK2A2 ) or ( FLJ25006 ) or ( NA ) or ( STK38 ) or ( PRPF4B ) or ( PRKCE ) or ( CDKL3 ) or ( MARK4 ) or ( PRKCD ) or ( TGFBR2 ) or ( STK16 ) or ( BMPR1A ) or ( TRAD ) or ( COL4A3BP ) or ( PIM1 ) or ( MAPK11 ) or ( LIMK2 ) or ( ERK8 ) or ( MAP3K14 ) or ( PRKCB1 ) or ( PRKG1 ) or ( IRAK3 ) or ( IRAK4 ) or ( NA ) or ( STK25 ) or ( PRKCA ) or ( PCTK2 ) or ( NA ) or ( NA ) or ( NA ) or ( PSKH1 ) or ( CDKL2 ) or ( CSNK2A1 ) or ( IKBKB ) or ( CSNK1G3 ) or ( STK36 ) or ( BUB1 ) or ( STK31 ) or ( CDKL5 ) or ( NA ) or ( MGC45428 ) or ( NEK11 ) or ( NA ) or ( NA ) or ( PDPK1 ) or ( NA ) or ( STK33 ) or ( NA ) or ( AMHR2 ) or ( PRKCM ) or ( MOS ) or ( FLJ90524 ) or ( PRKCSH ) or ( IKBKE ) or ( LIMK1 ) or ( KIS ) or ( IRAK2 ) or ( ACVR1B ) or ( MINK ) or ( NEK9 ) or ( STK22B ) or ( MAPK14 ) or ( MKNK2 ) or ( CDK10 ) or ( NA ) or ( MKNK1 ) or ( PRKCN ) or ( BMPR1B ) or ( STK11 ) or ( NEK4 ) or ( NA ) or ( MAP3K10 ) or ( STK10 ) or ( ICK ) or ( ILK-2 ) or ( PRKACA ) or ( NA ) or ( NEK6 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine/threonine kinase 18 ) or ( casein kinase I, alpha isoform ) or ( serine-protein kinase atm ) or ( serine/threonine kinase 6 ) or ( casein kinase I, gamma 1 isoform ) or ( cAMP-dependent protein kinase, beta-catalytic subunit ) or ( serine/threonine kinase 17B ) or ( myotonin kinase ) or ( activin receptor type IIb precursor ) or ( cGMP-dependent protein kinase 2 ) or ( protein kinase C, zeta type ) or ( cyclin G-associated kinase ) or ( tousled-like kinase 1 ) or ( TGF-beta receptor type I precursor ) or ( serine/threonine kinase 29 ) or ( cyclin-dependent kinases regulatory subunit 1 ) or ( inhibitor of nuclear factor kappa-B kinase alpha subunit ) or ( serine/threonine-protein kinase KKIALRE ) or ( MAP/microtubule affinity-regulating kinase 2 isoform B ) or ( casein kinase I, epsilon isoform ) or ( bone morphogenetic protein receptor type II precursor ) or ( Citron protein (fragment) ) or ( casein kinase I, gamma 2 isoform ) or ( mitogen activated kinase kinase kinase 14 ) or ( serine/threonine kinase STE20 like ) or ( protein Njmu-R1 ) or ( serine/threonine kinase 22A (spermiogenesis associated) ) or ( NEMO-like kinase ) or ( casein kinase ) or ( RAC-alpha serine/threonine kinase ) or ( serine/threonine-protein kinase receptor R3 precursor ) or ( serine/threonine kinase 38 like ) or ( serine/threonine protein kinase 12 ) or ( interleukin-1 receptor-associated kinase 1 ) or ( serine/threonine protein kinase 13 ) or ( TOUSLED-LIKE KINASE 2 ) or ( mixed lineage kinase MLK1 (fragment) ) or ( NF kappAB essential modulator NEMO NF kappAB essential modifier inhibitor of nuclear factor kappa B kinase gamma subunit IKB kinase gamma subunit I kappa B kinase gamma IKK gamma IKKG IKB kinase associated 1 IKKAP1 3 ) or ( cAMP-dependent protein kinase, gamma-catalytic subunit ) or ( serine/threonine protein kinase 4 ) or ( neurogranin ) or ( PAS domain containing serine/threonine kinase ) or ( DNA-dependent protein kinase catalytic subunit ) or ( cAMP dependent kinase catalytic subunit ) or ( mitogen activated kinase kinase 1 interacting 1 MEK binding partner 1 MP1 ) or ( heart alpha-kinase ) or ( PROTEIN KINASE C-LIKE 1 ) or ( LKB1 INTERACTING PROTEIN ) or ( serine/threonine-protein kinase PAK 7 ) or ( serine/threonine-protein kinase NEK1 ) or ( MAP/microtubule affinity-regulating kinase 1 ) or ( T-LAK CELL-ORIGINATED PROTEIN KINASE ) or ( cyclin dependent kinases regulatory subunit ) or ( serine/threonine kinase SULU ) or ( activin receptor type I precursor ) or ( serine/threonine kinase ) or ( serine/threonine kinase PSKH2 ) or ( activin receptor type II precursor ) or ( RAF proto oncogene serine/threonine kinase ) or ( serine/threonine-protein kinase NEK3 ) or ( mixed lineage kinase-related kinase MRK-beta ) or ( serine/threonine-protein kinase NEK2 ) or ( serine/threonine kinase ULK1 ) or ( serine/threonine-protein kinase 19 ) or ( glycogen synthase kinase-3 beta ) or ( serine/threonine protein kinase 3 ) or ( mitogen activated kinase kinase kinase 12 ) or ( protein kinase CLK1 ) or ( serine/threonine-protein kinase PIM-2 ) or ( serine/threonine kinase FKSQ81 ) or ( Fas-activated serine/threonine kinase ) or ( myotonin kinase ) or ( Traf2 and NCK interacting kinase, splice variant 6 ) or ( serine/threonine-protein kinase PFTAIRE-1 ) or ( protein kinase CHK2 isoform a ) or ( mitogen-activated protein kinase kinase kinase 12 ) or ( serine/threonine protein kinase 24 ) or ( serine/threonine kinase ) or ( protein kinase C, eta type ) or ( protein kinase C, gamma type ) or ( serine/threonine-protein kinase PAK 4 ) or ( cyclin-dependent kinases regulatory subunit 2 ) or ( RAF proto oncogene serine/threonine kinase ) or ( SERINE/THREONINE-PROTEIN KINASE ULK1 ) or ( SERINE/THREONINE-PROTEIN KINASE CHK1 ) or ( glycogen synthase kinase-3 alpha ) or ( cell division cycle 2-like protein kinase 5 ) or ( serine/threonine kinase 17A ) or ( cytokine-inducible serine/threonine-protein kinase ) or ( protein kinase C, theta type ) or ( serine/threonine kinase 23 ) or ( serine/threonine kinase 35 ) or ( cAMP-dependent protein kinase inhibitor, alpha form ) or ( hormonally upregulated Neu tumor-associated kinase ) or ( cyclin-dependent kinases regulatory subunit 1 ) or ( RAC-gamma serine/threonine protein kinase ) or ( mitogen-activated protein kinase 8 ) or ( NIMA (never in mitosis gene A)-related kinase 7 ) or ( casein kinase I alpha S-like ) or ( casein kinase II beta chain ) or ( protein kinase C, iota type ) or ( serine/threonine-protein kinase PCTAIRE-1 ) or ( casein kinase I, delta isoform ) or ( casein kinase II, alpha&apos; chain ) or ( ribosomal S6 kinase alpha ) or ( myotonin kinase ) or ( serine/threonine kinase 38 ) or ( serine/threonine-protein kinase PRP4 homolog ) or ( protein kinase C, epsilon type ) or ( cyclin-dependent kinase-like 3 ) or ( MAP/microtubule affinity-regulating kinase like 1 ) or ( protein kinase C, delta type ) or ( TGF-beta receptor type II precursor ) or ( serine/threonine protein kinase 16 ) or ( bone morphogenetic protein receptor type Ia precursor ) or ( serine/threonine kinase with DBLl- and pleckstrin homology domain ) or ( Goodpasture antigen-binding protein ) or ( proto-oncogene serine/threonine-protein kinase PIM-1 ) or ( mitogen-activated protein kinase 11 ) or ( LIM domain kinase 2 isoform 2a ) or ( extracellular signal-regulated kinase 8 ) or ( mitogen-activated protein kinase kinase kinase 14 ) or ( protein kinase C, beta type ) or ( protein kinase, cGMP-dependent, type I ) or ( interleukin-1 receptor-associated kinase 3 ) or ( interleukin-1 receptor-associated kinase 4 ) or ( serine/threonine kinase ) or ( serine/threonine protein kinase 25 ) or ( protein kinase C, alpha type ) or ( serine/threonine-protein kinase PCTAIRE-2 ) or ( mitogen activated kinase kinase kinase 12 ) or ( myotonin kinase ) or ( Citron Rho interacting serine/threonine kinase 21 ) or ( serine/threonine-protein kinase H1 ) or ( cyclin-dependent kinase-like 2 ) or ( casein kinase II, alpha chain ) or ( inhibitor of nuclear factor kappa B kinase beta subunit ) or ( casein kinase I, gamma 3 isoform ) or ( serine/threonine kinase 36 ) or ( MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1 ) or ( serine/threonine protein kinase 31 ) or ( serine/threonine-protein kinase 9 ) or ( serine/threonine kinase ) or ( serine/threonine kinase Dcamkl1 ) or ( NIMA (never in mitosis gene A)- related kinase 11 ) or ( serine/threonine kinase kinase ) or ( serine/threonine kinase 3 ) or ( 3-phosphoinositide dependent protein kinase-1 ) or ( 3-phosphoinositide dependent kinase 1 ) or ( serine/threonine kinase 33 ) or ( cyclin dependent kinases regulatory subunit ) or ( anti-Mullerian hormone type II receptor precursor ) or ( protein kinase C, mu ) or ( proto-oncogene serine/threonine-protein kinase Mos ) or ( serine/threonine kinase STE20 like ) or ( protein kinase C substrate, 80 kDa protein, heavy chain ) or ( inhibitor of nuclear factor kappa-B kinase epsilon subunit ) or ( LIM domain kinase 1 ) or ( serine/threonine-protein kinase Kist ) or ( interleukin-1 receptor-associated kinase-2 ) or ( serine/threonine-protein kinase receptor R2 precursor ) or ( misshapen/NIK-related kinase isoform 3 ) or ( NIMA related kinase 9 ) or ( serine/threonine kinase 22B (spermiogenesis associated) ) or ( mitogen-activated protein kinase 14 ) or ( MAP kinase-interacting serine/threonine kinase 2 ) or ( cyclin-dependent kinase 10 isoform 3 ) or ( serine/threonine kinase STE20 like ) or ( MAP kinase-interacting serine/threonine kinase 1 ) or ( protein kinase C, nu type ) or ( bone morphogenetic protein receptor type Ib precursor ) or ( SERINE/THREONINE-PROTEIN KINASE 11 ) or ( serine/threonine-protein kinase NEK4 ) or ( myotonin kinase ) or ( mitogen-activated protein kinase kinase kinase 10 ) or ( serine/threonine-protein kinase 10 ) or ( intestinal cell kinase isoform A ) or ( integrin-linked kinase-2 ) or ( cAMP-dependent protein kinase, alpha-catalytic subunit ) or ( serine/threonine kinase ) or ( putative serine-threonine protein kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PANTEPADENYLYLTRAN__45__RXN" name="Pantetheine-phosphate adenylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NBP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleotide binding protein )</html:p>
<html:p>SUBSYSTEM: coenzyme A biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.3</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PANTETHEINE__45__P" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEPHOSPHO__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARALKYLAMINE__45__N__45__ACETYLTRANSFERASE__45__RXN" name="Aralkylamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AANAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serotonin N-acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.87</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__2__45__Arylethylamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__N__45__Acetyl__45__2__45__Arylethylamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARACHIDONATE__45__5__45__LIPOXYGENASE__45__RXN" name="Arachidonate 5-lipoxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALOX5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 5-lipoxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.34</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_6E8Z11Z14Z__45__5S__45__5__45__HYDROPEROXYCOSA__45__6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NITRIC__45__OXIDE__45__SYNTHASE__45__RXN" name="Nitric-oxide synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NOSIP ) or ( NOSTRIN ) or ( NOS1 ) or ( NOS3 ) or ( NOS2C ) or ( NOS2B ) or ( NOS2A )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ENOS INTERACTING PROTEIN ) or ( nostrin ) or ( nitric-oxide synthase, brain ) or ( nitric-oxide synthase, endothelial ) or ( nitric-oxide synthase IIC (fragment) ) or ( nitric-oxide synthase IIB ) or ( nitric oxide synthase, inducible )</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.39</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NITRIC__45__OXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NITRIC__45__OXIDE" stoichiometry="1"/>
      <speciesReference species="L__45__CITRULLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__AMINOADIPATE__45__AMINOTRANSFERASE__45__RXN" name="2-aminoadipate aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( KATII )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-kynurenine/alpha-aminoadipate aminotransferase )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>SUBSYSTEM: lysine degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.39</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__468" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__ADIPATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GALACTOSE_TO_UDP_COF_RXN" name="UDP-GALACTOSE_TO_UDP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__3__46__1__46__4__45__RXN" name="Formiminotetrahydrofolate cyclodeaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FTCD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( formimidoyltransferase-cyclodeaminase )</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__671" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIPHOSPHOMEVALONTE__45__DECARBOXYLASE__45__RXN" name="Diphosphomevalonate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MVD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diphosphomevalonate decarboxylase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.33</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHOLINE__45__KINASE__45__RXN" name="Choline kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CHKL ) or ( CHK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carnitine O-palmitoyltransferase I, mitochondrial muscle isoform ) or ( choline kinase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.32</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NUCLEOSIDE__45__DIP__45__KIN__45__RXN" name="Nucleoside-diphosphate kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NME6 ) or ( NME4 ) or ( NME2 ) or ( NME3 ) or ( NME7 ) or ( NA ) or ( NME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase 6 ) or ( nucleoside diphosphate kinase, mitochondrial precursor ) or ( nucleoside diphosphate kinase B ) or ( nucleoside diphosphate kinase 3 ) or ( nucleoside diphosphate kinase 7 ) or ( putative nucleoside diphosphate kinase ) or ( nucleoside diphosphate kinase A )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Ribonucleoside__45__Diphosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Ribonucleoside__45__Triphosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__45__PHOSPHATIDYLINOSITOL__45__3__45__KINASE__45__RXN" name="1-phosphatidylinositol 3-kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PIK3R3 ) or ( P101-PI3K ) or ( PIK3CD ) or ( PIK3R4 ) or ( PIK3C2G ) or ( PIK3R1 ) or ( PIK3CB ) or ( PIK3CG ) or ( PIK3C2B ) or ( PIK3R2 ) or ( PIK3C3 ) or ( PIK3CA ) or ( PIK3C2A )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylinositol 3-kinase regulatory gamma subunit ) or ( phosphoinositide-3-kinase, regulatory subunit, polypeptide p101 ) or ( phosphatidylinositol 3-kinase catalytic subunit, delta isoform ) or ( phosphoinositide-3-kinase, regulatory subunit 4, p150 ) or ( phosphatidylinositol 3-kinase C2 domain-containing gamma polypeptide ) or ( phosphatidylinositol 3-kinase regulatory alpha subunit ) or ( phosphatidylinositol 3-kinase catalytic subunit, beta isoform ) or ( phosphatidylinositol 3-kinase catalytic subunit, gamma isoform ) or ( phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide ) or ( phosphatidylinositol 3-kinase regulatory beta subunit ) or ( phosphoinositide-3-kinase, class 3 ) or ( phosphatidylinositol 3-kinase catalytic subunit, alpha isoform ) or ( phosphoinositide-3-kinase, class 2, alpha polypeptide )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.137</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__L__45__1__45__phosphatidyl__45__inositols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__177" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_ACETYL__45__COA_COF_RXN" name="CO-A_TO_ACETYL-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__4__46__1__46__14__45__RXN" name="1-aminocyclopropane-1-carboxylate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PHACS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 1-aminocyclopropane-1-carboxylate synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.14</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__68" stoichiometry="1"/>
      <speciesReference species="_5__45__METHYLTHIOADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5223" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ10842 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( LIPID KINASE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TRIOSEPISOMERIZATION__45__RXN" name="Triosephosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TPI1 ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( triosephosphate isomerase ) or ( triosephosphate isomerase ) or ( triosephosphate isomerase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8351" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HMCS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( MOLYBDENUM COFACTOR SULFURASE )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="CPD__45__8123" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8124" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__45__AMINOLEVULINIC__45__ACID__45__SYNTHASE__45__RXN" name="5-aminolevulinic acid synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( ALAS2 ) or ( ALAS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 5 aminolevulinic acid synthase erythroid specific mitochondrial precursor ) or ( 5-aminolevulinic acid synthase, erythroid-specific, mitochondrial precursor ) or ( 5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.37</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: SUC__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: SUC__45__COA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__AMINO__45__LEVULINATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__221" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DDC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic-L-amino-acid decarboxylase )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__DIHYDROXY__45__PHENYLALANINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__45__45__RXN" name="N-acetylglucosamine-1-phosphodiester &amp;alpha;-N-acetylglucosaminidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( APAA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.45</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCOPROTEIN__45__ETCETERA__45__GLUCOSAMINYL__45__PHOSP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCOPROTEIN__45__PHOSPHO__45__D__45__MANNOSE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEHYDROGENASE__45__ACCEPTOR__45__RXN" name="Malate dehydrogenase (acceptor)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ12618 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( Malate dehydrogenase (acceptor) )</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.16</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="TIGLYLCOA__45__HYDROXY__45__RXN" name="Enoyl-CoA hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( FLJ10948 ) or ( HADHA ) or ( NA ) or ( EHHADH ) or ( ECHS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal bifunctional enzyme PBE PBFE ) or ( unknown ) or ( trifunctional enzyme alpha subunit, mitochondrial precursor ) or ( peroxisomal bifunctional enzyme PBE PBFE ) or ( peroxisomal bifunctional enzyme ) or ( enoyl-CoA hydratase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: isoleucine degradation I</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TIGLYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__METHYL__45__3__45__HYDROXY__45__BUTYRYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__99__45__RXN" name="[Pyruvate dehydrogenase(lipoamide)] kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PDK1 ) or ( PDK4 ) or ( PDK2 ) or ( PDK3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( (pyruvate dehydrogenase (lipoamide)) kinase isozyme 1, mitochondrial precursor ) or ( (pyruvate dehydrogenase (lipoamide)) kinase isozyme 4, mitochondrial precursor ) or ( (pyruvate dehydrogenase (lipoamide)) kinase isozyme 2, mitochondrial precursor ) or ( (pyruvate dehydrogenase (lipoamide)) kinase isozyme 3, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.99</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__PYRUVATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__PYRUVATE__32__DEHYDROGENASE__32____40__LIPOAMIDE__41____93____32__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPAMIDOTRANS__45__RXN" name="Amidophosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( PPAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amidophosphoribosyltransferase precursor ) or ( amidophosphoribosyltransferase precursor )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.14</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__P__45__BETA__45__D__45__RIBOSYL__45__AMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDP_TO_CTP_COF_RXN" name="CDP_TO_CTP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYGUANOSINE__45__KINASE__45__RXN" name="Deoxyguanosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DGUOK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyguanosine kinase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.113</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYGUANOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__2__46__3__46__12__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PTS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-pyruvoyl tetrahydrobiopterin synthase )</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrahydrobioprein biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.3.12</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="_6__45__PYRUVOYL__45__5678__45__TETRAHYDROPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5216" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MAN2C1 ) or ( MAN2A1 ) or ( NA ) or ( MAN2B1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-mannosidase 2C1 ) or ( alpha-mannosidase II ) or ( alpha-mannosidase ) or ( lysosomal alpha-mannosidase precursor )</html:p>
<html:p>SUBSYSTEM: 2-O-&amp;alpha;-mannosyl-D-glycerate degradation</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1063" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
      <speciesReference species="MANNOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ABP1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amiloride-sensitive amine oxidase (copper-containing) precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.22</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8751" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( XDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase ) or ( xanthine dehydrogenase/oxidase//xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYPOXANTHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8752" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( XDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase ) or ( xanthine dehydrogenase/oxidase//xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SULFITE__45__OXIDASE__45__RXN" name="Sulfite oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SUOX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sulfite oxidase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: sulfite oxidation IV</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.8.3.1</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8753" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( XDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase ) or ( xanthine dehydrogenase/oxidase//xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PURINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9017" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8754" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( XDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( xanthine dehydrogenase ) or ( xanthine dehydrogenase/oxidase//xanthine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9017" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9016" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="QOR__45__RXN" name="NADPH:quinone reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PIG3 ) or ( CRYZ ) or ( DONSON ) or ( KIAA1576 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( QUINONE OXIDOREDUCTASE HOMOLOG ) or ( quinone oxidoreductase ) or ( QUINONE OXIDOREDUCTASE-LIKE 1 ) or ( quinone oxidoreductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.6.5.5</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Quinones__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Semiquinones__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__45__KETOGLUTARATE_TO_GLT_COF_RXN" name="2-KETOGLUTARATE_TO_GLT_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__1__46__77__45__RXN" name="Acyloxyacyl hydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AOAH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyloxyacyl hydrolase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.77</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__ACYLOXYACYL__45__GROUP__45__OF__45__BACTERIAL__45__TOXIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
      <speciesReference species="_3__45__HYDROXYACYL__45__GROUP__45__OF__45__BACTERIAL__45__TOXIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMP__45__DEPHOSPHORYLATION__45__RXN" name="5&apos;-nucleotidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NT5C2 ) or ( NT5C1B ) or ( NT5C1A ) or ( NT5E ) or ( NT5M ) or ( NT5C3 ) or ( NT5C ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytosolic purine 5&apos;-nucleotidase ) or ( Pan2 protein ) or ( 5&apos;-nucleotidase, cytosolic ia ) or ( 5&apos;-nucleotidase precursor ) or ( 5&apos;,3&apos;-nucleotidase, mitochondrial precursor ) or ( 5&apos;-nucleotidase, cytosolic III ) or ( 5&apos;,3&apos;-nucleotidase, cytosolic ) or ( cytosolic purine 5&apos; nucleotidase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( OTC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine carbamoyltransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CARBAMOYL__45__P" stoichiometry="1"/>
      <speciesReference species="L__45__CANALINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="O__45__UREIDOHOMOSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__21__46__6__45__RXN" name="Lathosterol oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SC5DL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lathosterol oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 1.14.21.6</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__4186" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DOPAMINE__45__BETA__45__MONOOXYGENASE__45__RXN" name="Dopamine-&amp;beta;-monooxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DBH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dopamine &amp;beta;-monooxygenase subunit )</html:p>
<html:p>SUBSYSTEM: catecholamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 1.14.17.1</html:p>
<html:p>SIDE: L__45__DEHYDRO__45__ASCORBATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: ASCORBATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NOREPINEPHRINE" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__0" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diamine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__569" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCC__45__FUM__45__OXRED__45__RXN" name="Succinate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( SDHC ) or ( HSSUCCDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( succinate dehydrogenase cytochrome b560 subunit mitochondrial precursor integral membrane cII 3 qps1 qps 1 succinate dehydrogenase complex subunit c ) or ( succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor ) or ( succinate dehydrogenase flavoprotein subunit )</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SUC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PEPTIDYLGLYCINE__45__MONOOXYGENASE__45__RXN" name="Peptidylglycine monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PAMCI ) or ( PAM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor ) or ( peptidyl-glycine alpha-amidating monooxygenase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.17.3</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Glycines__124__" stoichiometry="1"/>
      <speciesReference species="ASCORBATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__8528" stoichiometry="1"/>
      <speciesReference species="L__45__DEHYDRO__45__ASCORBATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__281" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FDFT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl-diphosphate farnesyltransferase )</html:p>
<html:p>SUBSYSTEM: epoxysqualene biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis II (via 24,25-dihydrolanosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis III (via desmosterol)</html:p>
<html:p>SUBSYSTEM: cholesterol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.21</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__465" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN66__45__282" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SQLE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( squalene monooxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.7</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SQUALENE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="EPOXYSQUALENE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALPHAGALACTOSID__45__RXN" name="&amp;alpha;-galactosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GLA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-galactosidase a precursor )</html:p>
<html:p>SUBSYSTEM: melibiose degradation</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.22</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MELIBIOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
      <speciesReference species="GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="INDOLE__45__23__45__DIOXYGENASE__45__RXN" name="Indole 2,3-dioxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( INDO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( indoleamine 2,3-dioxygenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="INDOLE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__248" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LEUKOTRIENE__45__B4__45__20__45__MONOOXYGENASE__45__RXN" name="Leukotriene-B4 20-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP4F3 ) or ( CYP4F2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 4F3 ) or ( cytochrome p450 4F2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.30</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_6Z8E10E14Z__45__5S12R__45__512__45__DIHYDROXYI" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_20__45__OH__45__LTB4" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_325__45__BISPHOSPHATE__45__NUCLEOTIDASE__45__RXN" name="3&apos;(2&apos;),5&apos;-bisphosphate nucleotidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BPNT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3&apos;(2&apos;), 5&apos;-bisphosphate nucleotidase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PAP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERDECARB__45__RXN" name="Phosphatidylserine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PISD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine decarboxylase )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.65</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__ETHANOLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEAROYL__45__COA__45__DESATURASE__45__RXN" name="Stearoyl-CoA desaturase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ21032 ) or ( SCD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA desaturase ) or ( acyl-CoA desaturase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="STEAROYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OLEOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__65__45__RXN" name="Galactoside 3(4)-L-fucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FUT6 ) or ( FUT3 ) or ( FUT5 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-(1,3)-fucosyltransferase ) or ( galactoside 3(4)-l-fucosyltransferase ) or ( alpha-(1,3)-fucosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.65</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_13__45__BETA__45__D__45__GALACTOSYL__45__N__45__ACETYL__45__D__45__GLUCO" stoichiometry="1"/>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_13__45__BETA__45__D__45__GALACTOSYL__45__14__45__ALPHA__45__L__45__FU" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CEREBROSIDE__45__SULFATASE__45__RXN" name="Cerebroside-sulfatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ARSA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arylsulfatase a precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.6.8</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GALACTOSYLCERAMIDE__45__SULFATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="A__45__GALACTOSYLCERAMIDE" stoichiometry="1"/>
      <speciesReference species="SULFATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTARYL__45__COA__45__DEHYDROG__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GCDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl-CoA dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: glutaryl-CoA degradation</html:p>
<html:p>SUBSYSTEM: tryptophan degradation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLUTACONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCGLU__45__SEMIALDEHYDE__45__SUCCGLU__45__RXN" name="1-pyrroline-5-carboxylate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH4A1 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldehyde dehydrogenase 4A1 precursor ) or ( delta-1-pyrroline 5 carboxylate dehydrogenase mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.12</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N2__45__SUCCINYLGLUTAMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ASPARTASE__45__RXN" name="Aspartate ammonia-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( BA215B13.2 (fragment) )</html:p>
<html:p>SUBSYSTEM: glutamate degradation II</html:p>
<html:p>SUBSYSTEM: superpathway of aspartate and asparagine biosynthesis; interconversion of aspartate and asparagine.</html:p>
<html:p>SUBSYSTEM: glutamine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.3.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__SULFINYL__45__PYRUVATE__45__SPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__SULFINYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SPHINGOMYELIN__45__PHOSPHODIESTERASE__45__RXN" name="Sphingomyelin phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LOC51190 ) or ( SMPD3 ) or ( SMPD2 ) or ( NSMAF ) or ( SMPD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( neutral sphingomyelinase ) or ( sphingomyelin phosphodiesterase 3, neutral membrane ) or ( sphingomyelin phosphodiesterase 2 ) or ( protein FAN ) or ( sphingomyelin phosphodiesterase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.12</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Sphingomyelins__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
      <speciesReference species="CERAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__OXIDASE__45__RXN" name="Catechol oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TYR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosinase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.10.3.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__385" stoichiometry="2"/>
    </listOfProducts>
  </reaction>
  <reaction id="CHLORDECONE__45__REDUCTASE__45__RXN" name="Chlordecone reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AKR1C4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aldo-keto reductase family 1 member C4 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.225</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHLORDECONE__45__ALCOHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CHLORDECONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2301" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( IVD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( isovaleryl-CoA dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.10</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ISOVALERYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__METHYL__45__CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DUDPKIN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NME6 ) or ( NME4 ) or ( NME2 ) or ( NME3 ) or ( NME7 ) or ( NA ) or ( NME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( nucleoside diphosphate kinase 6 ) or ( nucleoside diphosphate kinase, mitochondrial precursor ) or ( nucleoside diphosphate kinase B ) or ( nucleoside diphosphate kinase 3 ) or ( nucleoside diphosphate kinase 7 ) or ( putative nucleoside diphosphate kinase ) or ( nucleoside diphosphate kinase A )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.6</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DUDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DUTP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DEOXYRIBOSE__45__P__45__ALD__45__RXN" name="Deoxyribose-phosphate aldolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CGI-26 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative deoxyribose-phosphate aldolase )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>SUBSYSTEM: purine deoxyribonucleosides degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXY__45__RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GAP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTDEAM__45__RXN" name="Cytosine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DJ20N2.1 (fragment) )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYTOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="URACIL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__2__46__1__46__141__45__RXN" name="4-&amp;alpha;-D-{(1->4)-&amp;alpha;-D-glucano}-trehalose trehalohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-amylase precursor )</html:p>
<html:p>SUBSYSTEM: trehalose biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.141</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MALTOOLIGOSYLTREHALOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TREHALOSE" stoichiometry="1"/>
      <speciesReference species="CPD__45__1790" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__26__45__RXN" name="N4-(&amp;beta;-N-acetylglucosaminyl)-L-asparaginase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( AGA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N(4)-(beta-N-acetylglucosaminyl)-l-asparaginase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.26</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__ETCETERA__45__L__45__ASPARAGINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
      <speciesReference species="N__45__ACETYL__45__BETA__45__GLUCOSAMINYLAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROPIONYL__45__COA__45__CARBOXY__45__RXN" name="Propionyl-CoA carboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PCCA and PCCB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL PRECURSOR and PROPIONYL-COA CARBOXYLASE ALPHA CHAIN, MITOCHONDRIAL PRECURSOR )</html:p>
<html:p>SUBSYSTEM: methylmalonyl pathway</html:p>
<html:p>SUBSYSTEM: isoleucine degradation III</html:p>
<html:p>PROTEIN_CLASS: 6.4.1.3</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROPIONYL__45__COA" stoichiometry="1"/>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D__45__METHYL__45__MALONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__DECARBOXYLASE__45__RXN" name="UDP-glucuronate decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UXS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UDP-glucuronate decarboxylase 1 )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: UDP-D-xylose biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.35</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__D__45__XYLOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MYO__45__INOSITOL__45__1OR__45__4__45__MONOPHOSPHATASE__45__RXN" name="Myo-inositol-1(or 4)-monophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( IMPA1 ) or ( IMPA2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( myo-inositol-1(or 4)-monophosphatase ) or ( myo-inositol-1(or 4)-monophosphatase 2 )</html:p>
<html:p>SUBSYSTEM: myo-inositol biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.25</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_1__45__L__45__MYO__45__INOSITOL__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="MYO__45__INOSITOL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALANINE__45____45__GLYOXYLATE__45__AMINOTRANSFERASE__45__RXN" name="Alanine--glyoxylate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AGXT2 ) or ( MGC15875 ) or ( AGXT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alanine--glyoxylate aminotransferase 2, mitochondrial precursor ) or ( alanine glyoxylate aminotransferase 2 mitochondrial precursor ) or ( serine--pyruvate aminotransferase )</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.44</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>SIDE: L__45__ALPHA__45__ALANINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYOX" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTMPKI__45__RXN" name="Thymidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DTYMK ) or ( DTYMK ) or ( NA ) or ( NA ) or ( DTYMK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( thymidylate kinase ) or ( thymidylate kinase ) or ( thymidylate kinase homologue ) or ( thymidylate kinase homologue ) or ( thymidylate kinase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__46__45__RXN" name="Fructose-2,6-bisphosphate 2-phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PFKFB1 ) or ( PFKFB3 ) or ( PFKFB2 ) or ( PFKFB4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1//6-phosphofructo-2-kinase ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 ) or ( 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4//6-phosphofructo-2-kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__535" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROID__45__17__45__ALPHA__45__MONOOXYGENASE__45__RXN" name="Steroid 17-&amp;alpha;-monooxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP17A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytochrome p450 17 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.9</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__17__45__Alpha__45__Hydroxysteroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTAGLY__45__RXN" name="Cystathionine &amp;gamma;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CTH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cystathionine gamma-lyase )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis/homocysteine degradation</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__OXOBUTANOATE" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ALDOSE__45__1__45__EPIMERASE__45__RXN" name="Aldose 1-epimerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LOC130589 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ambiguous )</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>SUBSYSTEM: trehalose degradation V</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN3O__45__117" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: ubiquinone-6 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UBIQUINOL__45__30" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UBIQUINONE__45__6" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__114__45__RXN" name="Hexaprenyldihydroxybenzoate methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COQ3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hexaprenyldihydroxybenzoate methyltransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: ubiquinone-6 biosynthesis (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.114</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HEXAPRENYL__45__45__45__DIHYDROXYBENZOATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__HEXAPRENYL__45__4__45__HYDROXY__45__5__45__METHOXYBENZOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTEINE__45__DIOXYGENASE__45__RXN" name="Cysteine dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CDO1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cysteine dioxygenase type i )</html:p>
<html:p>SUBSYSTEM: superpathway of methionine degradation</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation I</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation VI</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.20</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__SULFINOALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__1__46__1__46__249__45__RXN" name="[eIF-5A]-deoxyhypusine synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DHPS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( deoxyhypusine synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.249</html:p>
<html:p>GENERIC: true</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__91__eIF__45__5A__93____45__lysine" stoichiometry="1"/>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__91__eIF__45__5A__93____45__deoxyhypusine" stoichiometry="1"/>
      <speciesReference species="CPD__45__313" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__10__46__1__45__RXN" name="Receptor protein-tyrosine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TYRO3 ) or ( SYK ) or ( YES1 ) or ( DDR1 ) or ( EPHB2 ) or ( EPHA8 ) or ( KSR ) or ( ZAP70 ) or ( EPHA3 ) or ( FGFR2 ) or ( ALK ) or ( WEE1 ) or ( BTK ) or ( EPHB3 ) or ( LCK ) or ( FLJ33655 ) or ( FLJ23074 ) or ( HCK ) or ( EPHA4 ) or ( EPHA2 ) or ( JAK2 ) or ( MST1R ) or ( NTRK1 ) or ( MET ) or ( KDR ) or ( ABL2 ) or ( SRC ) or ( FGFR4 ) or ( ERBB3 ) or ( NTRK3 ) or ( MATK ) or ( MAPK1 ) or ( ROS1 ) or ( INSRR ) or ( KIT ) or ( MUSK ) or ( ABL1 ) or ( IGF1R ) or ( BLK ) or ( NA ) or ( FGR ) or ( DKFZp434C1418 ) or ( PTK2B ) or ( PDGFRA ) or ( NA ) or ( FGFR1 ) or ( TXK ) or ( TIE ) or ( PTK2 ) or ( JAK2 ) or ( RET ) or ( FLT1 ) or ( LOC51086 ) or ( EPHA1 ) or ( C20orf64 ) or ( EPHA5 ) or ( TEC ) or ( LYN ) or ( ITK ) or ( NTRK2 ) or ( SRMS ) or ( DDR2 ) or ( FRK ) or ( LTK ) or ( MNAT1 ) or ( RYK ) or ( EPHB1 ) or ( DDR1 ) or ( BMX ) or ( NA ) or ( INSR ) or ( DKFZp761P1010 ) or ( EPHB4 ) or ( FER ) or ( ROR2 ) or ( TYK2 ) or ( PDGFRB ) or ( NA ) or ( PTK9L ) or ( PTK7 ) or ( JAK1 ) or ( NA ) or ( EPHA7 ) or ( NA ) or ( FLT4 ) or ( PTK6 ) or ( FLT3 ) or ( FES ) or ( JAK3 ) or ( MERTK ) or ( CSK ) or ( FGFR3 ) or ( TEK ) or ( ERBB2 ) or ( NA ) or ( EGFR ) or ( AXL ) or ( FYN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine-protein kinase receptor TYRO3 precursor ) or ( tyrosine-protein kinase Syk ) or ( proto-oncogene tyrosine-protein kinase Yes ) or ( epithelial discoidin domain receptor 1 precursor ) or ( ephrin type-B receptor 2 precursor ) or ( ephrin type-A receptor 8 precursor ) or ( kinase suppressor of Ras-1 (fragment) ) or ( tyrosine-protein kinase ZAP-70 ) or ( ephrin type-A receptor 3 precursor ) or ( fibroblast growth factor receptor 2 precursor ) or ( ALK tyrosine kinase receptor precursor ) or ( Wee1-like protein kinase ) or ( tyrosine-protein kinase BTK ) or ( ephrin receptor EphB3 precursor ) or ( lymphocyte-specific protein tyrosine kinase ) or ( ephrin type receptor ) or ( mitogen activated kinase kinase kinase 5 ) or ( tyrosine-protein kinase HCK ) or ( ephrin type-A receptor 4 precursor ) or ( ephrin type-A receptor 2 precursor ) or ( tyrosine-protein kinase JAK2 ) or ( macrophage-stimulating protein receptor precursor ) or ( high affinity nerve growth factor receptor precursor ) or ( hepatocyte growth factor receptor precursor ) or ( vascular endothelial growth factor receptor 2 precursor ) or ( tyrosine-protein kinase Abl2 ) or ( proto-oncogene tyrosine-protein kinase Src ) or ( fibroblast growth factor receptor 4 precursor ) or ( receptor protein-tyrosine kinase ErbB-3 precursor ) or ( NT-3 growth factor receptor precursor ) or ( megakaryocyte-associated tyrosine-protein kinase ) or ( mitogen-activated protein kinase 1 ) or ( proto-oncogene tyrosine-protein kinase ROS precursor ) or ( insulin receptor-related protein precursor ) or ( mast/stem cell growth factor receptor precursor ) or ( muscle, skeletal, receptor tyrosine kinase ) or ( proto-oncogene tyrosine-protein kinase ABL1 ) or ( insulin-like growth factor I receptor precursor ) or ( tyrosine-protein kinase BLK ) or ( Wee1 like kinase ) or ( proto-oncogene tyrosine-protein kinase Fgr ) or ( ephrin type receptor ) or ( protein tyrosine kinase 2 beta ) or ( alpha-platelet-derived growth factor receptor precursor ) or ( mitogen activated kinase kinase kinase 5 ) or ( basic fibroblast growth factor receptor 1 precursor ) or ( tyrosine-protein kinase TXK ) or ( tyrosine-protein kinase receptor Tie-1 precursor ) or ( focal adhesion kinase 1 ) or ( tyrosine-protein kinase JAK2 ) or ( proto-oncogene tyrosine-protein kinase receptor RET precursor ) or ( vascular endothelial growth factor receptor 1 precursor ) or ( putative protein-tyrosine kinase ) or ( ephrin type-A receptor 1 precursor ) or ( p53-related protein kinase ) or ( ephrin type-A receptor 5 precursor ) or ( tyrosine-protein kinase Tec ) or ( tyrosine-protein kinase LYN ) or ( tyrosine-protein kinase ITK/TSK ) or ( BDNF/NT-3 growth factors receptor precursor ) or ( tyrosine-protein kinase Srms ) or ( discoidin domain receptor 2 precursor ) or ( tyrosine-protein kinase FRK ) or ( leukocyte tyrosine kinase receptor precursor ) or ( CDK-activating kinase assembly factor MAT1 ) or ( tyrosine-protein kinase NYK precursor ) or ( ephrin receptor EphB1 precursor ) or ( discoidin receptor tyrosine kinase isoform b ) or ( cytoplasmic tyrosine-protein kinase BMX ) or ( tyrosine kinase ) or ( insulin receptor precursor ) or ( receptor precursor ) or ( ephrin type-B receptor 4 precursor ) or ( proto-oncogene tyrosine-protein kinase Fer ) or ( tyrosine-protein kinase transmembrane receptor Ror2 precursor ) or ( non-receptor tyrosine-protein kinase TYK2 ) or ( macrophage colony stimulating factor I receptor precursor ) or ( receptor tyrosine kinase ErbB ) or ( PTK9l protein tyrosine kinase 9-like ) or ( tyrosine-protein kinase-like 7 precursor ) or ( tyrosine-protein kinase JAK1 ) or ( receptor tyrosine kinase isoform FLT4 long (fragment) ) or ( ephrin type-A receptor 7 precursor ) or ( ephrin type receptor ) or ( vascular endothelial growth factor receptor 3 precursor ) or ( tyrosine-protein kinase 6 ) or ( FL cytokine receptor precursor ) or ( V-FES feline sarcoma viral/V-FPS fujinami avian sarcoma viral oncogene homolog ) or ( tyrosine-protein kinase JAK3 ) or ( proto-oncogene tyrosine-protein kinase MER precursor ) or ( tyrosine-protein kinase CSK ) or ( fibroblast growth factor receptor 3 precursor ) or ( angiopoietin-1 receptor precursor ) or ( receptor protein-tyrosine kinase ErbB-2 precursor ) or ( receptor tyrosine kinase ErbB ) or ( epidermal growth factor receptor precursor ) or ( tyrosine-protein kinase receptor UFO precursor ) or ( proto-oncogene tyrosine-protein kinase Fyn )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.10.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Tyrosines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__tyrosine__45__phosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARGSUCCINLYA__45__RXN" name="Argininosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ASL ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( argininosuccinate lyase ) or ( argininosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: arginine biosynthesis IV</html:p>
<html:p>SUBSYSTEM: citrulline-nitric oxide cycle</html:p>
<html:p>SUBSYSTEM: urea cycle</html:p>
<html:p>SUBSYSTEM: superpathway of citrulline metabolism</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.1</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ARGININO__45__SUCCINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ARG" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIS5__45__ADENOSYL__45__TRIPHOSPHATASE__45__RXN" name="Bis(5&apos;-adenosyl)-triphosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FHIT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fragile histidine triad gene )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.29</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENOSINE5TRIPHOSPHO5ADENOSINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3902" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GCDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glutaryl-CoA dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.7</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6841" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( GPD2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol 3 phosphate dehydrogenase mitochondrial precursor ) or ( glycerol-3-phosphate dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>PROTEIN_CLASS: 1.1.99.5</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NAD__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ME2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NAD-dependent malic enzyme, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.38</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_7__45__DEHYDROCHOLESTEROL__45__REDUCTASE__45__RXN" name="7-dehydrocholesterol reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DHCR7 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 7-dehydrocholesterol reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.1.21</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__4187" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HEMEOSYN__45__RXN" name="heme o biosynthesis" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( COX10 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protoheme IX farnesyltransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROTOHEME" stoichiometry="1"/>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HEME_O" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PGLYCDEHYDROG__45__RXN" name="Phosphoglycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PHGDHL1 ) or ( PHGDH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglycerate dehydrogenase like 1 ) or ( D-3-phosphoglycerate dehydrogenase )</html:p>
<html:p>SUBSYSTEM: serine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of serine and glycine biosynthesis I</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.95</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="G3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_3__45__P__45__HYDROXYPYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__214__45__RXN" name="Glycoprotein 3-&amp;alpha;-L-fucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FUT10 ) or ( FUT7 ) or ( FUT6 ) or ( FUT5 ) or ( FUT4 ) or ( FUT9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fucosyltransferase 10 ) or ( alpha-(1,3)-fucosyltransferase ) or ( alpha-(1,3)-fucosyltransferase ) or ( alpha-(1,3)-fucosyltransferase ) or ( alpha-(1,3)-fucosyltransferase ) or ( fucosyltransferase 9 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.214</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12" stoichiometry="1"/>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTCYSLIG__45__RXN" name="Glutamate--cysteine ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GCLC and GCLM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT and GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT )</html:p>
<html:p>SUBSYSTEM: &amp;gamma;-glutamyl cycle</html:p>
<html:p>SUBSYSTEM: glutathione biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__GAMMA__45__GLUTAMYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__902" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ECHS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( enoyl-CoA hydratase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: toluene degradation VI (anaerobic)</html:p>
<html:p>SUBSYSTEM: toluene degradation to benzoyl-CoA (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="E__45__PHENYLITACONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CARBOXYMETHYL__45__HYDROXYPHENYLPROPCOA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__125__45__RXN" name="Histone-arginine N-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ10640 ) or ( HRMT1L2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( protein arginine N-methyltransferase ) or ( protein arginine N-methyltransferase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.125</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Histone__45__L__45__arginines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Histone__45__N__45__o__45__methyl__45__arginines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__7__45__RXN" name="Saccharopine dehydrogenase (NAD+, L-lysine forming)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AASS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysine-ketoglutarate reductase /saccharopine dehydrogenase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.7</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SACCHAROPINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
      <speciesReference species="LYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8172" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>SUBSYSTEM: lysine degradation VII</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA1__45__PIPERIDEINE__45__2__45__CARBOXYLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETO__45__6__45__AMINO__45__CAPROATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THREOSPON__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of threonine metabolism</html:p>
<html:p>SUBSYSTEM: aminopropanol biosynthesis</html:p>
<html:p>SUBSYSTEM: threonine degradation III (to methylglyoxal)</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__OXOBUT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__ACETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMPSYN__45__RXN" name="Adenylosuccinate lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ADSL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate lyase )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.3.2.2</html:p>
<html:p>SIDE: FUM</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8173" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: NA</html:p>
<html:p>PROTEIN_ASSOCIATION: NA</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation IX</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>SUBSYSTEM: lysine degradation VI</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7682" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALLYSINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Protein__45__Disulfides__124___TO___124__Protein__45__Dithiols__124___COF_RXN" name="|Protein-Disulfides|_TO_|Protein-Dithiols|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Protein__45__Disulfides__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Protein__45__Dithiols__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="L__45__LACTATE__45__DEHYDROGENASE__45__RXN" name="L-lactate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( LDHA ) or ( NA ) or ( NA ) or ( NA ) or ( NA ) or ( LDHL ) or ( LDHC ) or ( LDHB ) or ( MGC23940 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( L-lactate dehydrogenase A chain ) or ( L-lactate dehydrogenase chain ) or ( L-lactate dehydrogenase chain ) or ( L-lactate dehydrogenase chain ) or ( L-lactate dehydrogenase chain ) or ( L-lactate dehydrogenase A-like ) or ( L-lactate dehydrogenase C chain ) or ( L-lactate dehydrogenase B chain ) or ( L-lactate dehydrogenase chain )</html:p>
<html:p>SUBSYSTEM: lactate oxidation</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to lactate</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.27</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROGENIIISYN__45__RXN" name="uroporphyrinogen-III synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UROS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uroporphyrinogen-III synthase )</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis I</html:p>
<html:p>SUBSYSTEM: tetrapyrrole biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.75</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HYDROXYMETHYLBILANE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__68__45__RXN" name="Glycoprotein 6-&amp;alpha;-L-fucosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FUT8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-(1,6)-fucosyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.68</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12" stoichiometry="1"/>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N4__45__N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__F6" stoichiometry="1"/>
      <speciesReference species="GDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_10__45__FORMYL__45__THF_TO_THF_COF_RXN" name="10-FORMYL-THF_TO_THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSACETYLGLUCOSAMINEMUT__45__RXN" name="Phosphoacetylglucosamine mutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PGM3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoacetylglucosamine mutase )</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-glucosamine biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__D__45__GLUCOSAMINE__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOLIPASE__45__A2__45__RXN" name="Phospholipase A2" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PLA2G4C ) or ( PLA2G2E ) or ( PLA2G4B ) or ( PLA2G3 ) or ( PLA2G1B ) or ( NA ) or ( PLA2G6 ) or ( PLA2G12 ) or ( OC90 ) or ( NA ) or ( PLA2G4A ) or ( PLA2G2D ) or ( IPLA2(GAMMA) ) or ( NA ) or ( PLA2G2F ) or ( PLA2G10 ) or ( YWHAZ ) or ( PLA2G5 ) or ( PLA2G2A ) or ( NA ) or ( PLA2G13 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phospholipase A2, group IVC ) or ( group IIE secretory phospholipase A2 precursor ) or ( phospholipase A2, group IVB ) or ( group III secretory phospholipase A2 precursor ) or ( phospholipase A2 precursor ) or ( phospholipase A2 ) or ( phospholipase A2, group VI (cytosolic, calcium-independent) ) or ( group XII secretory phospholipase A2 precursor ) or ( OTOCONIN 90 PRECURSOR ) or ( cytosolic phospholipase A2 cPLA2//phospholipase A2//ambiguous ) or ( cytosolic phospholipase A2//phospholipase A2 ) or ( group IID secretory phospholipase A2 precursor ) or ( intracellular membrane-associated calcium-independent phospholipase A2 gamma ) or ( phospholipase A2 ) or ( group IIF secretory phospholipase A2 precursor ) or ( group X secretory phospholipase A2 precursor ) or ( 14-3-3 protein zeta/delta ) or ( calcium-dependent phospholipase A2 precursor ) or ( phospholipase A2, membrane associated precursor ) or ( CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 ) or ( group XIII secretory phospholipase A2 precursor ) or ( phospholipase A2 )</html:p>
<html:p>SUBSYSTEM: phospholipases</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.4</html:p>
<html:p>SIDE: __124__Carboxylates__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHATIDYLCHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__Acylglycero__45__Phosphocholines__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDROFOLATEREDUCT__45__RXN" name="Dihydrofolate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DHFR ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydrofolate reductase ) or ( dihydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.3</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROFOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9015" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( C20orf16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( anon-37Cs )</html:p>
<html:p>SUBSYSTEM: &amp;beta;-alanine biosynthesis V</html:p>
<html:p>PROTEIN_CLASS: 1.5.3.11</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: SPERMIDINE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SPERMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SPERMIDINE" stoichiometry="1"/>
      <speciesReference species="CPD__45__6082" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__11__45__RXN" name="Glycogen (starch) synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GYS2 ) or ( GYS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen (starch) synthase, liver ) or ( glycogen (starch) synthase, muscle )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.11</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__GLUCOSE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__1__45__4__45__alpha__45__D__45__Glucan__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__1381" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( KIAA1560 ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol 3 phosphate acyltransferase mitochondrial precursor ) or ( mitochondrial glycerol 3-phosphate acyltransferase ) or ( glycerol-3-phosphate acyltransferase, mitochondrial precursor ) or ( glycerol 3 phosphate acyltransferase mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: triacylglycerol biosynthesis</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.15</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: __124__Fatty__45__Acyl__45__CoA__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACYL__45__SN__45__GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__11__46__17__45__RXN" name="Calcium/calmodulin-dependent protein kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CAMK2G ) or ( CAMK2D ) or ( CAMK1G ) or ( CAMK2B ) or ( CAMK1 ) or ( CAMKK1 ) or ( CAMK2A ) or ( CAMK4 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( calcium/calmodulin-dependent protein kinase type II gamma chain (fragment) ) or ( calcium/calmodulin-dependent protein kinase type II delta chain ) or ( CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE IG ) or ( calcium/calmodulin-dependent protein kinase type II beta chain ) or ( calcium/calmodulin-dependent protein kinase type i ) or ( CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE 1 ALPHA ISOFORM A ) or ( calcium/calmodulin-dependent protein kinase type II alpha chain ) or ( calcium/calmodulin-dependent protein kinase type IV catalytic chain )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.11.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PROSTAGLANDIN__45__ENDOPEROXIDE__45__SYNTHASE__45__RXN" name="Prostaglandin-endoperoxide synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PTGS1 ) or ( PTGS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( prostaglandin G/H synthase 1 precursor ) or ( prostaglandin G/H synthase 2 precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.99.1</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PROSTAGLANDIN__45__H2" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYTIDEAM__45__RXN" name="Cytidine deaminase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CDA ) or ( AICDA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cytidine deaminase ) or ( activation-induced cytidine deaminase )</html:p>
<html:p>SUBSYSTEM: (deoxy)ribose phosphate degradation</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine deoxyribonucleotides</html:p>
<html:p>SUBSYSTEM: degradation of pyrimidine deoxyribonucleosides</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.5</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DEOXYCYTIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DEOXYURIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DTDPGLUCDEHYDRAT__45__RXN" name="dTDP-glucose 4,6-dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TDPGD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dTDP-D-glucose 4,6-dehydratase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.46</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DTDP__45__D__45__GLUCOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DTDP__45__DEOH__45__DEOXY__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9024" name="Glucan 1,4-&amp;alpha;-glucosidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MGAM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( maltase-glucoamylase, intestinal//maltase//glucoamylase )</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>PROTEIN_CLASS: 3.2.1.3</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__9025" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PYGM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycogen phosphorylase, muscle form )</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.1</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD0__45__1027" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8161" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PIPOX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal sarcosine oxidase )</html:p>
<html:p>SUBSYSTEM: superpathway of lysine degradation</html:p>
<html:p>SUBSYSTEM: lysine degradation V</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__PIPECOLATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7682" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLOSUCCINATE__45__SYNTHASE__45__RXN" name="adenylosuccinate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( ADSS ) or ( ADSSL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( adenylosuccinate synthetase ) or ( adenylosuccinate synthetase ) or ( hypothetical protein FLJ38602 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.4.4</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: L__45__ASPARTATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMP" stoichiometry="1"/>
      <speciesReference species="L__45__ASPARTATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENYLOSUCC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIAMACTRANS__45__RXN" name="Diamine N-acetyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( diamine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.57</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Aliphatic__45__Alpha__45__Omega__45__Diamines__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Aliphatic__45__N__45__Acetyl__45__Diamines__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOGLUCMUT__45__RXN" name="Phosphoglucomutase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( PGM1 ) or ( PGM5 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphoglucomutase ) or ( phosphoglucomutase 1 (fragment) ) or ( phosphoglucomutase ) or ( phosphoglucomutase-like protein 5 ) or ( phosphoglucomutase )</html:p>
<html:p>SUBSYSTEM: GDP-glucose biosynthesis</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>SUBSYSTEM: glycogen degradation III (yeast)</html:p>
<html:p>SUBSYSTEM: glycogen degradation II</html:p>
<html:p>SUBSYSTEM: glucose and glucose-1-phosphate degradation</html:p>
<html:p>SUBSYSTEM: UDP-glucose conversion</html:p>
<html:p>SUBSYSTEM: glycogen degradation I</html:p>
<html:p>PROTEIN_CLASS: 5.4.2.2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6182" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucose-6-phosphate isomerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__GLC__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__4__46__37__45__RXN" name="2&apos;,3&apos;-cyclic nucleotide 3&apos;-phosphodiesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CNP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 2&apos;,3&apos;-cyclic nucleotide 3&apos;-phosphodiesterase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.37</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Cyclic__45__2__45__3__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__2__45__Prime__45__Ribonucleoside__45__Monophosphates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALATE__45__DEH__45__RXN" name="Malate dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MDH1 ) or ( MDH2 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( malate dehydrogenase, cytoplasmic ) or ( malate dehydrogenase, mitochondrial precursor ) or ( malate dehydrogenase cytoplasmic )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: serine-isocitrate lyase pathway</html:p>
<html:p>SUBSYSTEM: aspartate degradation II</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.37</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OXALACETIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__7" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( COMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( catechol O-methyltransferase, membrane-bound form )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.6</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7650" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__9" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( SULT1A3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( monoamine-sulfating phenol sulfotransferase )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 2.8.2.1</html:p>
<html:p>COFACTOR: PAP</html:p>
<html:p>COFACTOR: PAPS</html:p>
<html:p>SIDE: PAP</html:p>
<html:p>SIDE: PAPS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7649" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__8__46__3__46__5__45__RXN" name="Prenylcysteine oxidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MGC3265 ) or ( PCL1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( PRENYLCYSTEINE LYASE PRECURSOR ) or ( PRENYLCYSTEINE LYASE PRECURSOR )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.3.5</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__PRENYL__45__L__45__CYSTEINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="PRENAL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PNPOXI__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FLJ10535 ) or ( PNPO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine 5&apos;-phosphate oxidase ) or ( pyridoxine-5-prime-phosphate oxidase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIOTINIDASE__45__RXN" name="Biotinidase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BTD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( biotinidase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__574" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BIOTIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__14__46__13__46__98__45__RXN" name="Cholesterol 24-hydroxylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CYP46A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( CYTOCHROME P450 46 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.14.13.98</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__7239" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CATECHOL__45__O__45__METHYLTRANSFERASE__45__RXN" name="Catechol O-methyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LOC220074 ) or ( COMT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( similar to D07 gene//catechol-O-methyltransferase soluble form S comt ) or ( catechol O-methyltransferase, membrane-bound form )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.6</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CATECHOL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__400" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHOMEVALONATE__45__KINASE__45__RXN" name="Phosphomevalonate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PMVK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphomevalonate kinase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: mevalonate pathway</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__499" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__641" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUC4NACTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FUT10 ) or ( FUT7 ) or ( FUT4 ) or ( FUT9 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fucosyltransferase 10 ) or ( alpha-(1,3)-fucosyltransferase ) or ( alpha-(1,3)-fucosyltransferase ) or ( fucosyltransferase 9 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.-</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="C55__45__PP__45__GLCNAC__45__MANNACA" stoichiometry="1"/>
      <speciesReference species="TDP__45__FUC4NAC" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TDP" stoichiometry="1"/>
      <speciesReference species="C55__45__PP__45__GLCNAC__45__MANNACA__45__FUC4NAC" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__1__46__3__46__16__45__RXN" name="Serine/threonine specific protein phosphatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PPP3CC ) or ( PPP1R3C ) or ( NA ) or ( DUSP3 ) or ( PPEF2 ) or ( PPP4C ) or ( PPP1CB ) or ( NA ) or ( DUSP21 ) or ( CDKN3 ) or ( PPM1F ) or ( PPP2R5B ) or ( PPP2R2C ) or ( ILKAP ) or ( PPP1R3A ) or ( PPM1A ) or ( DUSP13 ) or ( DUSP8 ) or ( PPP2R5E ) or ( PPP3CA ) or ( DUSP2 ) or ( DUSP18 ) or ( PPP4R1L ) or ( PPP1R14C ) or ( PPP1CC ) or ( PPP2R3B ) or ( DUSP10 ) or ( PPP1R14D ) or ( NA ) or ( PPP1R3F ) or ( PPP1R15B ) or ( MGC1136 ) or ( PPP1R16B ) or ( PPP1R9A ) or ( DUSP4 ) or ( DKFZp761G058 ) or ( PPM1D ) or ( PPP5C ) or ( PPP2R3A ) or ( PPP2R1A ) or ( DUSP16 ) or ( PPP2CB ) or ( PPP3CB ) or ( PPP2R1B ) or ( PPP3R2 ) or ( PPP1R10 ) or ( LOC151242 ) or ( PPP2R4 ) or ( PPP4R2 ) or ( PPP1CA ) or ( PPP1R14B ) or ( PPP4R1 ) or ( PPP6C ) or ( PPP2R5C ) or ( NA ) or ( DUSP7 ) or ( PPP2CA ) or ( PPP1R12A ) or ( DUSP5 ) or ( PPP2R2A ) or ( DUSP11 ) or ( PPP1R1A ) or ( PPP2R5A ) or ( PPEF1 ) or ( DUSP1 ) or ( DUSP14 ) or ( PPP1R1B ) or ( PPP1R14A ) or ( PPP1R2 ) or ( PPP1R7 ) or ( DUSP12 ) or ( NA ) or ( PPP1R12C ) or ( PPP1R9B ) or ( DUSP6 ) or ( PPP1R13B ) or ( PPP1R10 ) or ( PPP1R16A ) or ( NA ) or ( DUSP9 ) or ( PPP1R15A ) or ( NA ) or ( PPP1R3D ) or ( PPP1R11 ) or ( PPP2R5D ) or ( DUSP15 ) or ( PPM2C ) or ( PR48 ) or ( PPM1B ) or ( NA ) or ( PPP2R2B ) or ( PPP1R3B ) or ( PPM1G )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine/threonine protein phosphatase 2B catalytic subunit, gamma isoform ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 5 ) or ( serine/threonine phosphatase with EF-hands 1 ) or ( dual specificity protein phosphatase 3 ) or ( serine/threonine protein phosphatase with EF-hands-2 ) or ( serine/threonine protein phosphatase 4 ) or ( serine/threonine protein phosphatase PP1-beta catalytic subunit ) or ( phosphatase 2C ) or ( dual specificity phosphatase ) or ( cyclin-dependent kinase inhibitor 3 ) or ( Ca(2+)/calmodulin-dependent protein kinase phosphatase ) or ( serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, beta isoform ) or ( serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, gamma isoform ) or ( integrin-linked kinase-associated serine/threonine phosphatase 2C ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 3 ) or ( protein phosphatase 2C alpha isoform ) or ( dual specificity protein phosphatase 13 ) or ( dual specificity phosphatase 8 ) or ( serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, epsilon isoform ) or ( serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform ) or ( dual specificity protein phosphatase 2 ) or ( dual specificity phosphatase ) or ( protein phosphatase 4, regulatory subunit 1-like ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 14C ) or ( serine/threonine protein phosphatase PP1-gamma catalytic subunit ) or ( protein phosphatase 2 (formerly 2A), regulatory subunit B&apos;&apos;, beta ) or ( dual specificity protein phosphatase 10 ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 14D ) or ( protein phosphatase 1 regulatory subunit 1A ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 3F ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 15B ) or ( dual specificity phosphatase ) or ( protein phosphatase 1 regulatory inhibitor subunit 16B ) or ( neurabin-I (fragment) ) or ( dual specificity protein phosphatase 4 ) or ( ambiguous ) or ( protein phosphatase 2C delta isoform ) or ( serine/threonine protein phosphatase 5 ) or ( serine/threonine protein phosphatase 2A, 72/130 kDa regulatory subunit B ) or ( serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, alpha isoform ) or ( dual specificity protein phosphatase 16 ) or ( serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform ) or ( serine/threonine protein phosphatase 2B catalytic subunit, beta isoform ) or ( serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, beta isoform ) or ( protein phosphatase 3 regulatory subunit B, beta isoform ) or ( protein phosphatase 1, regulatory subunit 10 ) or ( protein phosphatase 1 regulatory subunit 1A ) or ( protein phosphatase 2A, regulatory subunit B&apos; ) or ( protein phosphatase 4 regulatory subunit 2 ) or ( serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit ) or ( phospholipase C, beta 3, neighbor ) or ( protein phosphatase 4, regulatory subunit 1 ) or ( serine/threonine protein phosphatase 6 ) or ( serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, gamma isoform ) or ( calcineurin B subunit phosphatase 2B regulatory subunit phosphatase 3 regulatory subunit B alpha ) or ( dual specificity protein phosphatase 7 ) or ( serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 12A ) or ( dual specificity protein phosphatase 5 ) or ( serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform ) or ( dual specificity protein phosphatase 11 ) or ( protein phosphatase inhibitor 1 ) or ( serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform ) or ( serine/threonine protein phosphatase with EF-hands-1 ) or ( dual specificity protein phosphatase 1 ) or ( dual specificity protein phosphatase 14 ) or ( dopamine- and cAMP-regulated neuronal phosphoprotein ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 14A ) or ( protein phosphatase inhibitor 2 ) or ( protein phosphatase 1, regulatory subunit 7 ) or ( dual specificity protein phosphatase 12 ) or ( phosphatase 1 regulatory inhibitor subunit 16B TGF beta inhibited membrane associated CAAX box TIMAP ) or ( myosin binding subunit 85 ) or ( neurabin II ) or ( dual specificity protein phosphatase 6 ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 13B ) or ( protein phosphatase 1, regulatory subunit 10 ) or ( protein phosphatase 1 regulatory inhibitor subunit 16A ) or ( dual specificity phosphatase ) or ( dual specificity protein phosphatase 9 ) or ( protein phosphatase 1, regulatory subunit 15A ) or ( dual specificity phosphatase ) or ( protein phosphatase 1, regulatory subunit 3D ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 11 isoform 1 ) or ( serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform ) or ( dual specificity protein phosphatase 15 ) or ( protein phosphatase 2C, magnesium-dependent, catalytic subunit ) or ( serine/threonine protein phosphatase 2A, 48 kDa regulatory subunit B ) or ( protein phosphatase Cc beta isoform ) or ( dual specificity phosphatase ) or ( serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, beta isoform ) or ( protein phosphatase 1, regulatory (inhibitor) subunit 3B ) or ( protein phosphatase 2C gamma isoform )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.3.16</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__General__45__Phos__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__General__45__Protein__45__Substrates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__4" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MAOA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( amine oxidase (flavin-containing) A )</html:p>
<html:p>SUBSYSTEM: dopamine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.4</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOPAMINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_34__45__DIHYDROXYPHENYLACETALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMP__45__SYN__45__GLUT__45__RXN" name="GMP synthetase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GMPS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GMP synthase (glutamine-hydrolyzing) )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.2</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="XANTHOSINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN6666__45__2" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FAAH ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fatty-acid amide hydrolase ) or ( FATTY ACID AMIDE HYDROLASE )</html:p>
<html:p>SUBSYSTEM: anandamide degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__7598" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ETHANOL__45__AMINE" stoichiometry="1"/>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FPPSYN__45__RXN" name="geranyltranstransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( FDPS ) or ( GGPS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( farnesyl pyrophosphate synthetase FPP synthetase FPS farnesyl diphosphate synthetase ) or ( farnesyl pyrophosphate synthetase ) or ( geranylgeranyl pyrophosphate synthetase )</html:p>
<html:p>SUBSYSTEM: superpathway of cholesterol biosynthesis</html:p>
<html:p>SUBSYSTEM: trans,trans-farnesyl diphosphate biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
      <speciesReference species="GERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FARNESYL__45__PP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALIC__45__NADP__45__RXN" name="Malate dehydrogenase (oxaloacetate decarboxylating) (NADP+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ME3 ) or ( ME1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADP-dependent malic enzyme, mitochondrial precursor ) or ( NADP-dependent malic enzyme )</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.40</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>SIDE: NADPH</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>SIDE: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__45__HYDROXYPHENYLPYRUVATE__45__DIOXYGENASE__45__RXN" name="4-hydroxyphenylpyruvate dioxygenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HPD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 4-hydroxyphenylpyruvate dioxygenase )</html:p>
<html:p>SUBSYSTEM: tyrosine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.27</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="P__45__HYDROXY__45__PHENYLPYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HOMOGENTISATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__101__45__RXN" name="&amp;alpha;-1,3-mannosyl-glycoprotein &amp;beta;-1,2-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( MGAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.101</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__D__45__MANNOSYL__45__13__45__R1__45__BETA__45__D__45__MANNOSY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__12__45__ALPHA__45__D" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R9__45__RXN" name="Enoyl-CoA hydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( FLJ10948 ) or ( HADHA ) or ( NA ) or ( EHHADH ) or ( ECHS1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peroxisomal bifunctional enzyme PBE PBFE ) or ( unknown ) or ( trifunctional enzyme alpha subunit, mitochondrial precursor ) or ( peroxisomal bifunctional enzyme PBE PBFE ) or ( peroxisomal bifunctional enzyme ) or ( enoyl-CoA hydratase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.17</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__650" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CROTONYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CREATINE__45__KINASE__45__RXN" name="Creatine kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CKM ) or ( CKB ) or ( CKMT2 ) or ( CKMT1 ) or ( CKMT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( creatine kinase, M chain ) or ( creatine kinase, B chain ) or ( creatine kinase, sarcomeric mitochondrial precursor ) or ( creatine kinase, ubiquitous mitochondrial precursor ) or ( creatine kinase, ubiquitous mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.3.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CREATINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CREATINE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD_TO_NADH_COF_RXN" name="NAD_TO_NADH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYC3PDEHYDROGBIOSYN__45__RXN" name="Glycerol-3-phosphate dehydrogenase (NAD(P)+)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GPD1 ) or ( KIAA0089 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol-3-phosphate dehydrogenase (NAD+), cytoplasmic ) or ( glycerol 3 phosphate dehydrogenase (NAD+) cytoplasmic )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.94</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__ACETONE__45__PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="METHENYLTHFCYCLOHYDRO__45__RXN" name="Methenyltetrahydrofolate cyclohydrolase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( MTHFD2 ) or ( MTHFD1 ) or ( NA ) or ( NA ) or ( DKFZP586G1517 ) or ( NA ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( C1 tetrahydrofolate synthase cytoplasmic C1 THF synthase ) or ( bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase mitochondrial precursor ) or ( bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor ) or ( C-1-tetrahydrofolate synthase, cytoplasmic ) or ( C1 tetrahydrofolate synthase cytoplasmic C1 THF synthase ) or ( bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase mitochondrial precursor ) or ( C1 tetrahydrofolate synthase cytoplasmic C1 THF synthase ) or ( bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase mitochondrial precursor ) or ( bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: reductive acetyl coenzyme A pathway</html:p>
<html:p>SUBSYSTEM: histidine degradation III</html:p>
<html:p>SUBSYSTEM: glycine degradation I</html:p>
<html:p>SUBSYSTEM: folate transformations</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.9</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_10__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBOXYLESTERASE__45__RXN" name="Carboxylesterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CES2 ) or ( CES1 ) or ( ESD ) or ( CES1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carboxylesterase 2 ) or ( liver carboxylesterase precursor ) or ( esterase D ) or ( liver carboxylesterase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.1</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Carboxylic__45__esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Carboxylates__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2PGADEHYDRAT__45__RXN" name="Phosphopyruvate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ENO1 ) or ( ENO3 ) or ( ENO2 ) or ( ENO2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ALPHA ENOLASE ) or ( BETA ENOLASE ) or ( gamma enolase ) or ( gamma enolase )</html:p>
<html:p>SUBSYSTEM: glycolysis I</html:p>
<html:p>SUBSYSTEM: Entner-Doudoroff pathway II (non-phosphorylative)</html:p>
<html:p>SUBSYSTEM: glycolysis III</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: serine-isocitrate lyase pathway</html:p>
<html:p>SUBSYSTEM: glycolysis V</html:p>
<html:p>SUBSYSTEM: gluconeogenesis</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis and Entner-Doudoroff</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.11</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__PG" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GMKALT__45__RXN" name="T2-induced deoxynucleotide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GUK1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( guanylate kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DGMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DGDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCONOKIN__45__RXN" name="Gluconokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( PTK2 ) or ( TYK2 ) or ( PTK7 ) or ( NA ) or ( PTK9 ) or ( MAP3K11 ) or ( PTK2B ) or ( FGFR3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tyrosine kinase ) or ( focal adhesion kinase 1 ) or ( non-receptor tyrosine-protein kinase TYK2 ) or ( tyrosine-protein kinase-like 7 precursor ) or ( tyrosine kinase ) or ( PTK9 PROTEIN TYROSINE KINASE 9 ) or ( MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11 ) or ( protein tyrosine kinase 2 beta ) or ( fibroblast growth factor receptor 3 precursor )</html:p>
<html:p>SUBSYSTEM: superpathway of gluconate degradation</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.12</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLUCONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__2961" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__149__45__RXN" name="N-acetyllactosaminide &amp;beta;-1,3-N-acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( B3GNT6 ) or ( B3GNT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase ) or ( beta-1,3-galactosyltransferase 7 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.149</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GLUCOSAMINYL__45__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="N__45__ACETYL__45__BETA__45__D__45__GLUCOSAMINYL__45__13__45__ETCETERA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__99__46__8__45__RXN" name="&amp;alpha;-N-acetyl-neuraminide &amp;alpha;-2,8-sialyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SIAT8A ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase ) or ( alpha-N-acetyl neuraminide alpha-2,8-sialyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.99.8</html:p>
<html:p>COFACTOR: CMP__45__N__45__ACETYL__45__NEURAMINATE</html:p>
<html:p>COFACTOR: CMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__23__45__ETCETERA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ALPHA__45__N__45__ACETYLNEURAMINYL__45__28__45__ETCETERA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__45__HYDROXYISOBUTYRYL__45__COA__45__HYDROLASE__45__RXN" name="3-hydroxyisobutyryl-CoA hydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HIBCH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-hydroxyisobutyryl-coenzyme A hydrolase )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.2.4</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
      <speciesReference species="_3__45__HYDROXY__45__ISOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PHOSPHASERSYN__45__RXN" name="CDP-diacylglycerol--serine O-phosphatidyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PTDSS1 ) or ( PTDSS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidylserine synthase I ) or ( PHOSPHATIDYLSERINE SYNTHASE 2 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidyl-ethanolamine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.8</html:p>
<html:p>SIDE: SER</html:p>
<html:p>SIDE: CMP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__1__45__PHOSPHATIDYL__45__SERINE" stoichiometry="1"/>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BIOPTERIN_TO_TETRA__45__H__45__BIOPTERIN_COF_RXN" name="BIOPTERIN_TO_TETRA-H-BIOPTERIN_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="BIOPTERIN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TETRA__45__H__45__BIOPTERIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__6__46__1__46__10__45__RXN" name="6-pyruvoyltetrahydropterin synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PTS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 6-pyruvoyl tetrahydrobiopterin synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_2__45__AMINO__45__ETCETERA__45__TRIPHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__AMINO__45__ETCETERA__45__DIHYDROXYPTERIDINE" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="MALONYL__45__COA_TO_CO__45__A_COF_RXN" name="MALONYL-COA_TO_CO-A_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="MALONYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__88__45__RXN" name="Peptide deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( COG8 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( peptide deformylase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.88</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__1__46__3__46__20__45__RXN" name="N-acylneuraminate-9-phosphate synthase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( NANS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sialic acid synthase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.57</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHO__45__ENOL__45__PYRUVATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__841" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__624" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ORNDECARBOX__45__RXN" name="Ornithine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ODC1 ) or ( NA ) or ( OAZ1 ) or ( ODC-p )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine decarboxylase ) or ( ornithine decarboxylase ) or ( ornithine decarboxylase antizyme ) or ( ornithine decarboxylase-like protein )</html:p>
<html:p>SUBSYSTEM: superpathway of arginine and ornithine degradation</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of ornithine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: putrescine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.17</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__ORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PUTRESCINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCEROL__45__KIN__45__RXN" name="Glycerol kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( MGC40579 ) or ( GK2 ) or ( GK ) or ( GKP3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glycerol kinase ) or ( glycerol kinase ) or ( glycerol kinase, testis specific 2 ) or ( glycerol kinase ) or ( glycerol kinase, testis specific 1 )</html:p>
<html:p>SUBSYSTEM: glycerol degradation IV</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.30</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLYCEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYPYRUVATE__45__REDUCTASE__45__RXN" name="Hydroxypyruvate reductase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GRHPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxylate reductase/hydroxypyruvate reductase )</html:p>
<html:p>SUBSYSTEM: serine-isocitrate lyase pathway</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.81</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="URKI__45__RXN" name="Uridine kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UCK1 ) or ( UMPK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine-cytidine kinase 1 ) or ( uridine-cytidine kinase 2 )</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.48</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GTP</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETOLACTSYN__45__RXN" name="Acetolactate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ILVBL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ILVB (BACTERIAL ACETOLACTATE SYNTHASE)-LIKE )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: valine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.2.1.6</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRUVATE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__ACETO__45__LACTATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__2__46__1__46__27__45__RXN" name="Methylmalonate-semialdehyde dehydrogenase (acylating)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ALDH6A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( methylmalonate-semialdehyde dehydrogenase (acylating), mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: valine degradation I</html:p>
<html:p>PROTEIN_CLASS: 1.2.1.27</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>COFACTOR: PROPIONYL__45__COA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HCO3</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: NAD</html:p>
<html:p>SIDE: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CH3__45__MALONATE__45__S__45__ALD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HCO3" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__83__45__RXN" name="Dolichyl-phosphate &amp;beta;-D-mannosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DPM2 and DPM1 and DPM3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3 and dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit isoform 1 and DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE )</html:p>
<html:p>SUBSYSTEM: dolichyl-diphosphooligosaccharide biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.83</html:p>
<html:p>COFACTOR: GDP</html:p>
<html:p>COFACTOR: GDP__45__MANNOSE</html:p>
<html:p>SIDE: GDP</html:p>
<html:p>SIDE: GDP__45__MANNOSE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DOLICHOLP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__171" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PMPOXI__45__RXN" name="Pyridoxamine-phosphate oxidase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PNPO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( pyridoxine-5-prime-phosphate oxidase )</html:p>
<html:p>SUBSYSTEM: pyridoxal 5&apos;-phosphate salvage pathway</html:p>
<html:p>PROTEIN_CLASS: 1.4.3.5</html:p>
<html:p>SIDE: HYDROGEN__45__PEROXIDE</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: OXYGEN__45__MOLECULE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SUCCORN__45__AMINOTRANSFERASE__45__RXN" name="Ornithine--oxo-acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( OAT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( ornithine aminotransferase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.13</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="N2__45__SUCCINYLORNITHINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__822" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BETA__45__UREIDOPROPIONASE__45__RXN" name="&amp;beta;-ureidopropionase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UPB1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-ureidopropionase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.6</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__UREIDO__45__PROPIONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="B__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCERATE__45__DEHYDROGENASE__45__RXN" name="Glycerate dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GRHPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glyoxylate reductase/hydroxypyruvate reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.29</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OH__45__PYR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLYCERATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__7__46__15__45__RXN" name="Cholinephosphate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PCYT1A ) or ( PCYT1B )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( cholinephosphate cytidylyltransferase A ) or ( cholinephosphate cytidylyltransferase B )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: phosphatidylcholine biosynthesis</html:p>
<html:p>SUBSYSTEM: choline biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.15</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="PHOSPHORYL__45__CHOLINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP__45__CHOLINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADP_TO_NADPH_COF_RXN" name="NADP_TO_NADPH_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NADPH" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUCOSAMINE__45__6__45__P__45__DEAMIN__45__RXN" name="Glucosamine-6-phosphate isomerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SB52 ) or ( GNPI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( glucosamine-6-phosphate deaminase ) or ( glucosamine-6-phosphate deaminase )</html:p>
<html:p>SUBSYSTEM: N-acetylglucosamine degradation</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylneuraminate degradation</html:p>
<html:p>SUBSYSTEM: UDP-N-acetyl-D-galactosamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of N-acetylglucosamine, N-acetylmannosamine and N-acetylneuraminate degradation</html:p>
<html:p>PROTEIN_CLASS: 3.5.99.6</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__GLUCOSAMINE__45__6__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FRUCTOSE__45__6P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UTPHEXPURIDYLYLTRANS__45__RXN" name="UTP--hexose-1-phosphate uridylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GALT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( galactose-1-phosphate uridylyltransferase )</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: UTP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GALACTOSE__45__1P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GALACTOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ARACHIDONATE__45__12__45__LIPOXYGENASE__45__RXN" name="Arachidonate 12-lipoxygenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( ALOX12 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( arachidonate 12-lipoxygenase, 12S-type )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.13.11.31</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ARACHIDONIC_ACID" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5Z8Z10E14Z__45__12S__45__12__45__HYDROPEROXYICOS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8992" name="all-trans-octaprenyl-diphosphate synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( TPT )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trans-prenyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALL__45__TRANS__45__HEPTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="DELTA3__45__ISOPENTENYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OCTAPRENYL__45__DIPHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CDPDIGLYSYN__45__RXN" name="phosphatidate cytidylyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( CDS1 ) or ( CDS2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( phosphatidate cytidylyltransferase 1 ) or ( phosphatidate cytidylyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis I</html:p>
<html:p>SUBSYSTEM: phospholipid biosynthesis II</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis I</html:p>
<html:p>SUBSYSTEM: CDP-diacylglycerol biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.41</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: CTP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CTP" stoichiometry="1"/>
      <speciesReference species="L__45__PHOSPHATIDATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDPDIACYLGLYCEROL" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACYLCOADEHYDROG__45__RXN" name="Acyl-CoA dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( ACADM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( acyl-CoA dehydrogenase, medium-chain specific, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: fatty acid &amp;beta;-oxidation I</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.3</html:p>
<html:p>COFACTOR: FADH2</html:p>
<html:p>COFACTOR: FAD</html:p>
<html:p>SIDE: FADH2</html:p>
<html:p>SIDE: FAD</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Saturated__45__Fatty__45__Acyl__45__CoA__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="D2__45__ENOYL__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CARBONYL__45__REDUCTASE__45__NADPH__45__RXN" name="Carbonyl reductase (NADPH)" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( CBR3 ) or ( CBR1 ) or ( DCXR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( carbonyl reductase (NADPH) 3 ) or ( carbonyl reductase (NADPH) 1 ) or ( carbonyl reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.1.1.184</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LONG__45__CHAIN__45__KETONE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UDP__45__GLUCURONATE__45__5__45__EPIMERASE__45__RXN" name="UDP-glucuronate 5&apos;-epimerase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GLCE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( likely homolog of mouse glucuronyl C5-epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 5.1.3.12</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UDP__45__GLUCURONATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__223" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__34__45__RXN" name="6,7-dihydropteridine reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( QDPR )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dihydropteridine reductase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.34</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5678__45__TETRAHYDROPTERIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_67__45__DIHYDROPTERIDINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AMINOPARATHION__45__PHOSPHATASE__45__RXN" name="Aryldialkylphosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( PON1 ) or ( PON2 ) or ( PON3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serum paraoxonase/arylesterase 1 ) or ( serum paraoxonase/arylesterase 2 ) or ( serum paraoxonase/arylesterase 3 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.8.1</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMINO__45__PARATHION" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIETHYLTHIOPHOSPHATE" stoichiometry="1"/>
      <speciesReference species="CPD__45__259" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYCPDIESTER__45__RXN" name="Glycerophosphodiester phosphodiesterase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( MIR16 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( membrane interacting protein of RGS16 )</html:p>
<html:p>SUBSYSTEM: glycerol degradation I</html:p>
<html:p>PROTEIN_CLASS: 3.1.4.46</html:p>
<html:p>SIDE: __124__Alcohols__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Glycerophosphodiesters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Alcohols__124__" stoichiometry="1"/>
      <speciesReference species="GLYCEROL__45__3P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FUMHYDR__45__RXN" name="Fumarate hydratase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( FH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( fumarate hydratase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: mixed acid fermentation</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate bypass and TCA</html:p>
<html:p>SUBSYSTEM: respiration (anaerobic)</html:p>
<html:p>SUBSYSTEM: superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass</html:p>
<html:p>SUBSYSTEM: glutamate degradation VII</html:p>
<html:p>SUBSYSTEM: pyruvate fermentation to propionate I</html:p>
<html:p>SUBSYSTEM: superpathway of glyoxylate cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle</html:p>
<html:p>SUBSYSTEM: TCA cycle variation III (eukaryotic)</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.2</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="MAL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FUM" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AROMATIC__45__L__45__AMINO__45__ACID__45__DECARBOXYLASE__45__RXN" name="Aromatic-L-amino-acid decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( DDC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( aromatic-L-amino-acid decarboxylase )</html:p>
<html:p>SUBSYSTEM: tryptophan degradation VI (via tryptamine)</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.28</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="TRP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="TRYPTAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROL__45__O__45__ACYLTRANSFERASE__45__RXN" name="Sterol O-acyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SOAT1 ) or ( SOAT2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( sterol O-acyltransferase 1 ) or ( sterol O-acyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.26</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACYL__45__COA</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CHOLESTEROL" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Cholesterol__45__esters__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMPKI__45__RXN" name="Cytidylate kinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UMP-CMPK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UMP-CMP kinase )</html:p>
<html:p>SUBSYSTEM: salvage pathways of purine and pyrimidine nucleotides</html:p>
<html:p>SUBSYSTEM: salvage pathways of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.7.4.14</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CDP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FCLREDUCT__45__RXN" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TSTA3 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GDP-fucose synthetase//GDP-mannose-4-keto-6-D epimerase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.-.-.-</html:p>
<html:p>COFACTOR: NADPH</html:p>
<html:p>COFACTOR: NADP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GDP__45__4__45__DEHYDRO__45__6__45__L__45__DEOXYGALACTOSE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GUANOSINE_DIPHOSPHATE_FUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CMP__45__N__45__ACETYL__45__NEURAMINATE_TO_CMP_COF_RXN" name="CMP-N-ACETYL-NEURAMINATE_TO_CMP_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CMP__45__N__45__ACETYL__45__NEURAMINATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="AIRS__45__RXN" name="phosphoribosylformylglycinamidine cyclo-ligase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( GART )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( trifunctional purine biosynthetic protein adenosine-3 )</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis II</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: purine nucleotides de novo biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 6.3.3.1</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__N__45__FORMYLGLYCINEAMIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__PHOSPHORIBOSYL__45__5__45__AMINOIMIDAZOLE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="OROPRIBTRANS__45__RXN" name="Orotate phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( UMPS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( uridine 5&apos;-monophosphate synthase )</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of uridine-5&apos;-monophosphate</html:p>
<html:p>SUBSYSTEM: superpathway of histidine, purine, and pyrimidine biosynthesis</html:p>
<html:p>SUBSYSTEM: de novo biosynthesis of pyrimidine ribonucleotides</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.10</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="OROTATE" stoichiometry="1"/>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="OROTIDINE__45__5__45__PHOSPHATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__3__46__99__46__5__45__RXN" name="3-oxo-5-&amp;alpha;-steroid 4-dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( SRD5A2 ) or ( SRD5A1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( 3-oxo-5-alpha-steroid 4-dehydrogenase 2 ) or ( 3-oxo-5-alpha-steroid 4-dehydrogenase 1 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.3.99.5</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__3__45__Oxo__45__5__45__Alpha__45__Steroids__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__3__45__Oxo__45__Delta__45__4__45__Steroids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__4__46__1__46__102__45__RXN" name="&amp;beta;-1,3-galactosyl-O-glycosyl-glycoprotein &amp;beta;-1,6-N- acetylglucosaminyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( GCNT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N- acetylglucosaminyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.1.102</html:p>
<html:p>COFACTOR: UDP</html:p>
<html:p>COFACTOR: UDP__45__N__45__ACETYL__45__D__45__GLUCOSAMINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__GALACTOSAMINY" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="BETA__45__D__45__GALACTOSYL__45__ETCETERA__45__16__45__N__45__ACETYL__45__D" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CO__45__A_TO_SUC__45__COA_COF_RXN" name="CO-A_TO_SUC-COA_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SUC__45__COA" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUC1PURIDYLTRANS__45__RXN" name="UTP--glucose-1-phosphate uridylyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( UGP2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( UTP--glucose-1-phosphate uridylyltransferase 2 )</html:p>
<html:p>SUBSYSTEM: galactose degradation II</html:p>
<html:p>SUBSYSTEM: UDP-sugars interconversion</html:p>
<html:p>SUBSYSTEM: colanic acid building blocks biosynthesis</html:p>
<html:p>SUBSYSTEM: sucrose degradation III</html:p>
<html:p>SUBSYSTEM: glycogen biosynthesis II (from UDP-D-Glucose)</html:p>
<html:p>SUBSYSTEM: UDP-glucose conversion</html:p>
<html:p>SUBSYSTEM: UDP-galactose biosynthesis (salvage pathway from galactose using UDP-glucose)</html:p>
<html:p>PROTEIN_CLASS: 2.7.7.9</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UTP" stoichiometry="1"/>
      <speciesReference species="GLC__45__1__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="UDP__45__GLUCOSE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="FOLYLPOLYGLUTAMATESYNTH__45__RXN" name="folylpolyglutamate synthetase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( FPGS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( folylpolyglutamate synthase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: folate polyglutamylation I</html:p>
<html:p>PROTEIN_CLASS: 6.3.2.17</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="THF__45__GLU__45__N" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HYDROXYMETHYLGLUTARYL__45__COA__45__LYASE__45__RXN" name="Hydroxymethylglutaryl-CoA lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( HMGCL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( hydroxymethylglutaryl CoA lyase ) or ( hydroxymethylglutaryl-CoA lyase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>SUBSYSTEM: mevalonate degradation</html:p>
<html:p>PROTEIN_CLASS: 4.1.3.4</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_3__45__HYDROXY__45__3__45__METHYL__45__GLUTARYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
      <speciesReference species="_3__45__KETOBUTYRATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="STEROL__45__ESTERASE__45__RXN" name="Sterol esterase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( LIPA ) or ( LIPE ) or ( CEL )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( lysosomal acid lipase/cholesteryl ester hydrolase precursor ) or ( hormone sensitive lipase ) or ( bile-salt-activated lipase precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.1.1.13</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Steryl__45__Esters__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Sterols__124__" stoichiometry="1"/>
      <speciesReference species="__124__Fatty__45__Acids__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NAD__43____45__ADP__45__RIBOSYLTRANSFERASE__45__RXN" name="NAD(+) ADP-ribosyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( TNKS ) or ( NA ) or ( ADPRT ) or ( ADPRTL3 ) or ( TNKS2 ) or ( ADPRTL1 ) or ( NA ) or ( ADPRTL2 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( tankyrase 1 ) or ( Vault poly(ADP ribose) polymerase ) or ( poly (ADP-ribose) polymerase-1 ) or ( poly (ADP-ribose) polymerase-3 ) or ( tankyrase 2 ) or ( Vault poly(ADP-ribose) polymerase ) or ( poly (ADP ribose) polymerase 1 ) or ( poly (ADP-ribose) polymerase-2 )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.30</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: macro</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__ADP__45__D__45__Ribosyl__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="__40__ADP__45__D__45__RIBOSYL__41____40__N__41____45__ACCEPTOR" stoichiometry="1"/>
      <speciesReference species="NAD" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__ADP__45__D__45__Ribosyl__45__Acceptors__124__" stoichiometry="1"/>
      <speciesReference species="__40__ADP__45__D__45__RIBOSYL__41____40__N__43__1__41____45__ACCEPTOR" stoichiometry="1"/>
      <speciesReference species="NIACINAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIHYDLIPOXN__45__RXN" name="Dihydrolipoamide dehydrogenase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( DIA1 ) or ( DLD )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( NADH-cytochrome b5 reductase ) or ( dihydrolipoamide dehydrogenase, mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 1.8.1.4</html:p>
<html:p>COFACTOR: NAD</html:p>
<html:p>COFACTOR: NADH</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROLIPOAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="LIPOAMIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="BRANCHED__45__CHAINAMINOTRANSFERLEU__45__RXN" name="Branched-chain amino acid aminotransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( BCAT2 ) or ( BCAT1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( branched-chain amino acid aminotransferase, mitochondrial precursor ) or ( branched-chain amino acid aminotransferase, cytosolic )</html:p>
<html:p>SUBSYSTEM: superpathway of leucine, valine, and isoleucine biosynthesis</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>SUBSYSTEM: leucine degradation I</html:p>
<html:p>SUBSYSTEM: leucine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.42</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="LEU" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2K__45__4CH3__45__PENTANOATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__3701" name="Protein geranylgeranyltransferase type I" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( PGGT1B ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( GERANYLGERANYL TRANSFERASE TYPE I BETA SUBUNIT ) or ( GERANYLGERANYL TRANSFERASE TYPE I BETA SUBUNIT )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.59</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="GERANYLGERANYL__45__PP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__GERANYLGERANYL__45__PROTEIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SAMDECARB__45__RXN" name="Adenosylmethionine decarboxylase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( AMD1 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( S-adenosylmethionine decarboxylase proenzyme//s-adenosylmethionine decarboxylase alpha chain )</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis I</html:p>
<html:p>SUBSYSTEM: spermine biosynthesis</html:p>
<html:p>SUBSYSTEM: superpathway of polyamine biosynthesis II</html:p>
<html:p>SUBSYSTEM: spermidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.1.1.50</html:p>
<html:p>SIDE: CARBON__45__DIOXIDE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="S__45__ADENOSYLMETHIONINAMINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="DIMETHYLGLYCINE__45__DEHYDROGENASE__45__RXN" name="Dimethylglycine dehydrogenase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( NA ) or ( NA ) or ( DMGDH ) or ( FLJ10079 ) or ( NA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( dimethylglycine dehydrogenase mitochondrial precursor ) or ( dimethylglycine dehydrogenase mitochondrial precursor ) or ( dimethylglycine dehydrogenase, mitochondrial precursor ) or ( dimethylglycine dehydrogenase mitochondrial precursor ) or ( dimethylglycine dehydrogenase mitochondrial precursor )</html:p>
<html:p>SUBSYSTEM: glycine betaine degradation</html:p>
<html:p>PROTEIN_CLASS: 1.5.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>SIDE: FORMALDEHYDE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__GLYCINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="SARCOSINE" stoichiometry="1"/>
      <speciesReference species="FORMALDEHYDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
