<?xml version="1.0"  encoding="UTF-8"?>
<sbml xmlns="http://www.sbml.org/sbml/level2" version="1" level="2" xmlns:html="http://www.w3.org/1999/xhtml">
<model id="HODCD587_metabolic_network_metabolic_network" name="Candidatus Hodgkinia cicadicola">
<listOfCompartments>
<compartment id="cytoplasm"/>
</listOfCompartments>
<listOfSpecies>
  <species id="ALPHA__45__RIBAZOLE" name="&amp;alpha;-ribazole" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAMINE__45__5P" name="pyridoxamine 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__686" name="precorrin-8x" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROXY__45__BUTANONE__45__P" name="L-3,4-dihydroxybutan-2-one-4-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__687" name="hydrogenobyrinate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="APS" name="adenosine 5&apos;-phosphosulfate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ENZYME__45__S__45__SULFANYLCYSTEINE" name="a protein-S-sulfanylcysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Acceptor__124__" name="an oxidized electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYLCOBALAMIN" name="coenzyme B12" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__690" name="adenosyl-cobyrinate a,c-diamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__AMP" name="phosphoribosyl-AMP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SIROHYDROCHLORIN" name="sirohydrochlorin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__694" name="cob(I)yrinate a,c-diamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__691" name="adenosyl-cobyrate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__KETOGLUTARATE" name="2-oxoglutarate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__689" name="cob(II)yrinate a,c-diamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__688" name="hydrogenobyrinate a,c-diamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYLSERINE" name="O-acetyl-L-serine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETYL__45__COA" name="acetyl-CoA" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACETALD" name="acetaldehyde" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" name="formyl-L-methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__662" name="precorrin-5" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__651" name="precorrin-4" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__CYSTATHIONINE" name="cystathionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Donor__45__H2__124__" name="a reduced electron acceptor" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GMP" name="guanosine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" name="6,7-dimethyl-8-(1-D-ribityl)lumazine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYLCOBINAMIDE" name="adenosylcobinamide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CO__43__2" name="Co2+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOFLAVIN" name="riboflavin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHENYL__45__PYRUVATE" name="phenylpyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHIONYL__45__PEPTIDE" name="methionyl peptide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYL__45__HOMO__45__CYS" name="S-adenosyl-L-homocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHE" name="L-phenylalanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__HISTIDINOL__45__P" name="L-histidinol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GTP" name="guanosine 5&apos;-triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ATP" name="ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="RIBOSE__45__5P" name="D-ribose-5-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__643" name="precorrin-3B" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLY" name="glycine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" name="D-erythro-imidazole-glycerol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" name="phosphoribosylformiminoAICAR-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLN" name="L-glutamine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDRONEOPTERIN__45__P3" name="7,8-dihydroneopterin triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Purine__45__Diphosphates__124__" name="a purine diphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PRPP" name="5-phosphoribosyl 1-pyrophosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="GLT" name="L-glutamate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NADH__45__P__45__OR__45__NOP" name="NAD(P)H" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALPHA__45__RIBAZOLE__45__5__45__P" name="&amp;alpha;-ribazole-5&apos;-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PROT__45__CYS" name="a protein L-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ACET" name="acetate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBOSYL__45__ATP" name="phosphoribosyl-ATP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="D__45__ALANINE" name="D-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__METHYL__45__THF" name="5-methyl-THF" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="L__45__ALPHA__45__ALANINE" name="L-alanine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYLCOBINAMIDE__45__GDP" name="adenosylcobinamide-GDP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HS" name="hydrogen sulfide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMP" name="adenosine-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="THF" name="tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="COB__45__I__45__ALAMIN" name="cob(I)alamin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="FORMATE" name="formate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYLCOBALAMIN__45__5__45__P" name="adenosylcobalamin-5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADENOSYLCOBINAMIDE__45__P" name="adenosyl-cobinamide phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="HOMO__45__CYS" name="L-homocysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="DIHYDROSIROHYDROCHLORIN" name="precorrin-2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="P3I" name="PPPi" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRIDOXAL_PHOSPHATE" name="pyridoxal 5&apos;-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="COBALT__45__SIROHYDROCHLORIN" name="cobalt-sirohydrochlorin" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="NAD__45__P__45__OR__45__NOP" name="NAD(P)+" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ADP" name="ADP" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CO__45__A" name="coenzyme A" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="ALLO__45__THR" name="allothreonine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="__124__Purine__45__Triphosphates__124__" name="a purine triphosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="UROPORPHYRINOGEN__45__III" name="uroporphyrinogen-III" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_2__45__THIOURIDINE" name="2-thiouridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="IMIDAZOLE__45__ACETOL__45__P" name="imidazole acetol-phosphate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SER" name="L-serine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="SO3" name="sulfite" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9038" name="precorrin-1" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9039" name="cobalt-precorrin-2" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="METHYLENE__45__THF" name="5,10-methylene-THF" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="URIDINE" name="uridine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" name="phosphoribulosylformimino-AICAR-P" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__10__45__METHENYL__45__THF" name="5,10-methenyltetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="PYRUVATE" name="pyruvate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CYS" name="L-cysteine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="S__45__ADENOSYLMETHIONINE" name="S-adenosyl-L-methionine" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AICAR" name="aminoimidazole carboxamide ribonucleotide" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9042" name="cobalt-precorrin-5A" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9041" name="cobalt-precorrin-4" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="CPD__45__9040" name="cobalt-precorrin-3" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" name="5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
  <species id="_5__45__FORMYL__45__THF" name="5-formyl-tetrahydrofolate" initialAmount="0" compartment="cytoplasm" boundaryCondition="false" />
</listOfSpecies>
<listOfReactions>
  <reaction id="PHEAMINOTRANS__45__RXN" name="Aromatic amino acid transferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_158_hisC ) or ( HCDSEM_158_2_hisC ) or ( HCDSEM_158_3_hisC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative histidinol-phosphate aminotransferase ) or ( putative histidinol-phosphate aminotransferase ) or ( putative histidinol-phosphate aminotransferase )</html:p>
<html:p>SUBSYSTEM: phenylalanine biosynthesis I</html:p>
<html:p>SUBSYSTEM: phenylalanine degradation II (anaerobic)</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.57</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHENYL__45__PYRUVATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="THF_TO_METHYLENE__45__THF_COF_RXN" name="THF_TO_METHYLENE-THF_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_4__46__99__46__1__46__3__45__RXN" name="Sirohydrochlorin cobaltochelatase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_005_2_cbiX ) or ( HCDSEM_005_cbiX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative sirohydrochlorin cobaltochelatase ) or ( putative sirohydrochlorin cobaltochelatase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.3</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SIROHYDROCHLORIN" stoichiometry="1"/>
      <speciesReference species="CO__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="COBALT__45__SIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLT_TO_2__45__KETOGLUTARATE_COF_RXN" name="GLT_TO_2-KETOGLUTARATE_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__KETOGLUTARATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5234" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_135_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 4.1.2.5</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALLO__45__THR" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETALD" stoichiometry="1"/>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_ADP_COF_RXN" name="ATP_TO_ADP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALADENOSYLTRANS__45__RXN" name="Cob(I)alamin adenosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_004_cobO ) or ( HCDSEM_004_3_cobO ) or ( HCDSEM_004_2_cobO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cob(I)alamin adenosyltransferase ) or ( putative cob(I)alamin adenosyltransferase ) or ( putative cob(I)alamin adenosyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="COB__45__I__45__ALAMIN" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
      <speciesReference species="P3I" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_3__46__5__46__1__46__88__45__RXN" name="Peptide deformylase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_109_def )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative peptide deformylase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 3.5.1.88</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="FORMYL__45__L__45__METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="FORMATE" stoichiometry="1"/>
      <speciesReference species="METHIONYL__45__PEPTIDE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLYOHMETRANS__45__RXN" name="glycine hydroxymethyltransferase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_135_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>SUBSYSTEM: glycine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.1.2.1</html:p>
<html:p>COFACTOR: METHYLENE__45__THF</html:p>
<html:p>COFACTOR: THF</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLY" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="__124__Acceptor__124___TO___124__Donor__45__H2__124___COF_RXN" name="|Acceptor|_TO_|Donor-H2|_COF_RXN" reversible="true">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="__124__Acceptor__124__" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Donor__45__H2__124__" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="NADH__45__P__45__OR__45__NOP_TO_NAD__45__P__45__OR__45__NOP_COF_RXN" name="NADH-P-OR-NOP_TO_NAD-P-OR-NOP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="NADH__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="NAD__45__P__45__OR__45__NOP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__5240" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_135_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAL_PHOSPHATE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="PYRIDOXAMINE__45__5P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALAMIN5PSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_176_cobS ) or ( HCDSEM_176_2_cobS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cobalamin 5&apos;-phosphate synthase ) or ( putative cobalamin 5&apos;-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.26</html:p>
<html:p>SIDE: GMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__RIBAZOLE__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYLCOBALAMIN__45__5__45__P" stoichiometry="1"/>
      <speciesReference species="GMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8675" name="Uroporphyrinogen-III C-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_013_2_cobA ) or ( HCDSEM_013_cobA ) or ( HCDSEM_013_3_cobA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative uroporphyrin-III c-methyltransferase ) or ( putative uroporphyrin-III c-methyltransferase ) or ( putative uroporphyrin-III c-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GTP__45__CYCLOHYDRO__45__I__45__RXN" name="GTP cyclohydrolase I" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_048_folE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative GTP cyclohydrolase I )</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis II</html:p>
<html:p>SUBSYSTEM: tetrahydrofolate biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: FORMATE</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="GTP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIHYDRONEOPTERIN__45__P3" stoichiometry="1"/>
      <speciesReference species="FORMATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_1__46__5__46__1__46__20__45__RXN" name="Methylenetetrahydrofolate reductase (NADPH)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_030_metF ) or ( HCDSEM_030_2_metF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 5,10-methylenetetrahydrofolate reductase ) or ( putative 5,10-methylenetetrahydrofolate reductase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: 1.5.1.20</html:p>
<html:p>COFACTOR: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>COFACTOR: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: NAD__45__P__45__OR__45__NOP</html:p>
<html:p>SIDE: NADH__45__P__45__OR__45__NOP</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="METHYLENE__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__METHYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__133__45__RXN" name="Precorrin-4 C11-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_010_2_cobM ) or ( HCDSEM_010_3_cobM ) or ( HCDSEM_010_cobM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative precorrin-4 C11-methyltransferase ) or ( putative precorrin-4 C11-methyltransferase ) or ( putative precorrin-4 C11-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.133</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__651" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__662" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="COBALAMINSYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_176_cobS ) or ( HCDSEM_176_2_cobS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cobalamin 5&apos;-phosphate synthase ) or ( putative cobalamin 5&apos;-phosphate synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin salvage from cobinamide and cobalamin</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>PROTEIN_CLASS: 2.7.8.26</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="ALPHA__45__RIBAZOLE" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__GDP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GMP" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBALAMIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ADENYLYLSULFATE__45__REDUCTASE__45__RXN" name="Adenylylsulfate reductase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_162_5_cysH ) or ( HCDSEM_162_4_cysH ) or ( HCDSEM_162_cysH ) or ( HCDSEM_162_2_cysH ) or ( HCDSEM_162_3_cysH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative adenylylsulfate reductase ) or ( putative adenylylsulfate reductase ) or ( putative adenylylsulfate reductase ) or ( putative adenylylsulfate reductase ) or ( putative adenylylsulfate reductase )</html:p>
<html:p>SUBSYSTEM: sulfite oxidation II</html:p>
<html:p>SUBSYSTEM: sulfite oxidation III</html:p>
<html:p>PROTEIN_CLASS: 1.8.99.2</html:p>
<html:p>COFACTOR: __124__Donor__45__H2__124__</html:p>
<html:p>COFACTOR: __124__Acceptor__124__</html:p>
<html:p>SIDE: __124__Donor__45__H2__124__</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>SIDE: __124__Acceptor__124__</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="AMP" stoichiometry="1"/>
      <speciesReference species="SO3" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="APS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__6321" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_135_glyA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( serine hydroxymethyltransferase )</html:p>
<html:p>SUBSYSTEM: formylTHF biosynthesis II</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="_5__45__10__45__METHENYL__45__THF" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_5__45__FORMYL__45__THF" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R345__45__RXN" name="Adenosylcobyric acid synthase (glutamine-hydrolyzing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_001_3_cobQ ) or ( HCDSEM_001_2_cobQ ) or ( HCDSEM_001_4_cobQ ) or ( HCDSEM_001_cobQ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cobyric acid synthase CobQ ) or ( putative cobyric acid synthase CobQ ) or ( putative cobyric acid synthase CobQ ) or ( putative cobyric acid synthase CobQ )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.10</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__691" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTPRATPHYD__45__RXN" name="Phosphoribosyl-ATP pyrophosphatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_028_hisI ) or ( HCDSEM_028_2_hisI ) or ( HCDSEM_028_3_hisI )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoribosyl-ATP diphosphatase ) or ( putative phosphoribosyl-ATP diphosphatase ) or ( putative phosphoribosyl-ATP diphosphatase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.6.1.31</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLUTAMIDOTRANS__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_025_2_hisH ) or ( HCDSEM_025_hisH ) or ( HCDSEM_027_hisF )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( imidazole glycerol phosphate synthase, glutamine amidotransferase subunit ) or ( imidazole glycerol phosphate synthase, glutamine amidotransferase subunit ) or ( putative imidazoleglycerol phosphate synthase, cyclase subunit )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.-</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AICAR" stoichiometry="1"/>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RIBOFLAVIN__45__SYN__45__RXN" name="Riboflavin synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_137_2_ribC ) or ( HCDSEM_137_ribC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative riboflavin synthase subunit alpha ) or ( putative riboflavin synthase subunit alpha )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.9</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="2"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
      <speciesReference species="RIBOFLAVIN" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACETYL__45__COA_TO_CO__45__A_COF_RXN" name="ACETYL-COA_TO_CO-A_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ACETYL__45__COA" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CO__45__A" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="IMIDPHOSDEHYD__45__RXN" name="Imidazoleglycerol-phosphate dehydratase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_024_2_hisB ) or ( HCDSEM_024_hisB ) or ( HCDSEM_024_3_hisB )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative imidazoleglycerol-phosphate dehydratase ) or ( putative imidazoleglycerol-phosphate dehydratase ) or ( putative imidazoleglycerol-phosphate dehydratase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 4.2.1.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="D__45__ERYTHRO__45__IMIDAZOLE__45__GLYCEROL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__1__46__1__46__131__45__RXN" name="Precorrin-3B C17-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_009_2_cobJ ) or ( HCDSEM_009_3_cobJ ) or ( HCDSEM_009_cobJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative precorrin-3B C17-methyltransferase ) or ( putative precorrin-3B C17-methyltransferase ) or ( putative precorrin-3B C17-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.131</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__643" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__651" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRIBFAICARPISOM__45__RXN" name="N-(5&apos;-phospho-D-ribosylformimino)-5-amino-1-(5&apos;&apos;-phosphoribosyl)-4- imidazole carboxamide isomerase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_026_hisA ) or ( HCDSEM_026_2_hisA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ) or ( putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 5.3.1.16</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBULOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_2__46__7__46__1__46__156__45__RXN" name="Adenosylcobinamide kinase" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_002_cobP ) or ( HCDSEM_002_2_cobP ) or ( HCDSEM_002_3_cobP )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative adenosylcobinamide kinase ) or ( putative adenosylcobinamide kinase ) or ( putative adenosylcobinamide kinase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: 2.7.1.156</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="__124__Purine__45__Triphosphates__124__" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="__124__Purine__45__Diphosphates__124__" stoichiometry="1"/>
      <speciesReference species="ADENOSYLCOBINAMIDE__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="CYSTATHIONINE__45__BETA__45__LYASE__45__RXN" name="Cystathionine &amp;beta;-lyase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_144_2_metC ) or ( HCDSEM_144_3_metC ) or ( HCDSEM_144_metC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cystathionine beta-lyase ) or ( putative cystathionine beta-lyase ) or ( putative cystathionine beta-lyase )</html:p>
<html:p>SUBSYSTEM: methionine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.8</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: PYRUVATE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="L__45__CYSTATHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
      <speciesReference species="HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__308" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_039_3_sufS ) or ( HCDSEM_039_4_sufS ) or ( HCDSEM_039_2_sufS ) or ( HCDSEM_039_sufS )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cysteine desulfurase, SufS subfamily ) or ( putative cysteine desulfurase, SufS subfamily ) or ( putative cysteine desulfurase, SufS subfamily ) or ( putative cysteine desulfurase, SufS subfamily )</html:p>
<html:p>SUBSYSTEM: alanine biosynthesis III</html:p>
<html:p>PROTEIN_CLASS: 2.8.1.7</html:p>
<html:p>SIDE: PROT__45__CYS</html:p>
<html:p>SIDE: ENZYME__45__S__45__SULFANYLCYSTEINE</html:p>
<html:p>GENERIC: true</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PROT__45__CYS" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
      <speciesReference species="ENZYME__45__S__45__SULFANYLCYSTEINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="PRPPSYN__45__RXN" name="ribose-phosphate diphosphokinase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_095_prs )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ribose-phosphate diphosphokinase )</html:p>
<html:p>SUBSYSTEM: PRPP biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.7.6.1</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="RIBOSE__45__5P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PRPP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LCYSDESULF__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_144_metC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cystathionine beta-lyase )</html:p>
<html:p>SUBSYSTEM: L-cysteine degradation II</html:p>
<html:p>PROTEIN_CLASS: 4.4.1.1</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: AMMONIA</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: HS</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="PYRUVATE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="GLN_TO_GLT_COF_RXN" name="GLN_TO_GLT_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="GLN" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="GLT" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R341__45__RXN" name="hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: (  ) or (  ) or (  ) or (  ) or (  )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cobyrinic acid a,c-diamide synthase ) or ( putative cobyrinic acid a,c-diamide synthase ) or ( putative cobyrinic acid a,c-diamide synthase ) or ( putative cobyrinic acid a,c-diamide synthase ) or ( putative cobyrinic acid a,c-diamide synthase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 6.3.5.9</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: GLN</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__687" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__688" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="S__45__ADENOSYLMETHIONINE_TO_ADENOSYL__45__HOMO__45__CYS_COF_RXN" name="S-ADENOSYLMETHIONINE_TO_ADENOSYL-HOMO-CYS_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="S__45__ADENOSYLMETHIONINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ADENOSYL__45__HOMO__45__CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATPPHOSPHORIBOSYLTRANS__45__RXN" name="ATP phosphoribosyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_140_hisG ) or ( HCDSEM_140_3_hisG ) or ( HCDSEM_140_2_hisG )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative ATP phosphoribosyltransferase ) or ( putative ATP phosphoribosyltransferase ) or ( putative ATP phosphoribosyltransferase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.4.2.17</html:p>
<html:p>SIDE: PPI</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PRPP" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__ATP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="_5__46__4__46__1__46__2__45__RXN" name="Precorrin-8X methylmutase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_006_cobH )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative precorrin-8X methylmutase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 5.4.1.2</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__686" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__687" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R342__45__RXN" name="Cobaltochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_046_5 ) or ( HCDSEM_003_2_cobN ) or ( HCDSEM_046_4 ) or ( HCDSEM_003_3_cobN ) or ( HCDSEM_003_7_cobN ) or ( HCDSEM_003_cobN ) or ( HCDSEM_046_3 ) or ( HCDSEM_046 ) or ( HCDSEM_046_2 ) or ( HCDSEM_003_5_cobN ) or ( HCDSEM_003_4_cobN ) or ( HCDSEM_003_6_cobN ) or ( HCDSEM_003_8_cobN )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cobaltochelatase, pCobS small subunit ) or ( putative cobaltochelatase, CobN subunit ) or ( putative cobaltochelatase, pCobS small subunit ) or ( putative cobaltochelatase, CobN subunit ) or ( putative cobaltochelatase, CobN subunit ) or ( putative cobaltochelatase, CobN subunit ) or ( putative cobaltochelatase, pCobS small subunit ) or ( putative cobaltochelatase, pCobS small subunit ) or ( putative cobaltochelatase, pCobS small subunit ) or ( putative cobaltochelatase, CobN subunit ) or ( putative cobaltochelatase, CobN subunit ) or ( putative cobaltochelatase, CobN subunit ) or ( putative cobaltochelatase, CobN subunit )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>PROTEIN_CLASS: 6.6.1.2</html:p>
<html:p>COFACTOR: ADP</html:p>
<html:p>COFACTOR: __124__Pi__124__</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: ADP</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: CO__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CO__43__2" stoichiometry="1"/>
      <speciesReference species="CPD__45__688" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__689" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8762" name="Precorrin-4 C11-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_010_2_cobM ) or ( HCDSEM_010_3_cobM ) or ( HCDSEM_010_cobM )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative precorrin-4 C11-methyltransferase ) or ( putative precorrin-4 C11-methyltransferase ) or ( putative precorrin-4 C11-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.133</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9041" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9042" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="R344__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_004_cobO ) or ( HCDSEM_004_3_cobO ) or ( HCDSEM_004_2_cobO )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cob(I)alamin adenosyltransferase ) or ( putative cob(I)alamin adenosyltransferase ) or ( putative cob(I)alamin adenosyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide II</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis from cobyrinate a,c-diamide I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.17</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ATP</html:p>
<html:p>SIDE: P3I</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__694" stoichiometry="1"/>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="P3I" stoichiometry="1"/>
      <speciesReference species="CPD__45__690" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ACSERLY__45__RXN" name="Cysteine synthase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_110_cysK ) or ( HCDSEM_110_2_cysK )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative cysteine synthase A ) or ( putative cysteine synthase A )</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.5.1.47</html:p>
<html:p>SIDE: ACET</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="HS" stoichiometry="1"/>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACET" stoichiometry="1"/>
      <speciesReference species="CYS" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8761" name="Precorrin-3B C17-methyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_009_2_cobJ ) or ( HCDSEM_009_3_cobJ ) or ( HCDSEM_009_cobJ )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative precorrin-3B C17-methyltransferase ) or ( putative precorrin-3B C17-methyltransferase ) or ( putative precorrin-3B C17-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.131</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CPD__45__9040" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9041" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="SERINE__45__O__45__ACETTRAN__45__RXN" name="Serine O-acetyltransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_145_cysE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative serine acetyltransferase )</html:p>
<html:p>SUBSYSTEM: cysteine biosynthesis I</html:p>
<html:p>PROTEIN_CLASS: 2.3.1.30</html:p>
<html:p>COFACTOR: CO__45__A</html:p>
<html:p>COFACTOR: ACETYL__45__COA</html:p>
<html:p>SIDE: CO__45__A</html:p>
<html:p>SIDE: ACETYL__45__COA</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="SER" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="ACETYLSERINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="LUMAZINESYN__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_141_ribE )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative 6,7-dimethyl-8-ribityllumazine synthase )</html:p>
<html:p>SUBSYSTEM: flavin biosynthesis</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>SIDE: __124__Pi__124__</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROXY__45__BUTANONE__45__P" stoichiometry="1"/>
      <speciesReference species="AMINO__45__RIBOSYLAMINO__45__1H__45__3H__45__PYR__45__DIONE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="DIMETHYL__45__D__45__RIBITYL__45__LUMAZINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN__45__8759" name="Sirohydrochlorin cobaltochelatase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_005_2_cbiX ) or ( HCDSEM_005_cbiX )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative sirohydrochlorin cobaltochelatase ) or ( putative sirohydrochlorin cobaltochelatase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 4.99.1.3</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: CO__43__2</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="DIHYDROSIROHYDROCHLORIN" stoichiometry="1"/>
      <speciesReference species="CO__43__2" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9039" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="ATP_TO_AMP_COF_RXN" name="ATP_TO_AMP_COF_RXN" reversible="false">
    <notes>
      <html:p>GENE_ASSOCIATION: </html:p>
      <html:p>PROTEIN_ASSOCIATION: </html:p>
      <html:p>SUBSYSTEM: NA</html:p>
      <html:p>PROTEIN_CLASS: null</html:p>
      <html:p>GENERIC: false</html:p>
      <html:p>HOLE: true</html:p>
    </notes>
    <listOfReactants>
      <speciesReference species="ATP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="AMP" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTAMINOTRANS__45__RXN" name="Histidinol-phosphate aminotransferase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_158_hisC ) or ( HCDSEM_158_2_hisC ) or ( HCDSEM_158_3_hisC )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative histidinol-phosphate aminotransferase ) or ( putative histidinol-phosphate aminotransferase ) or ( putative histidinol-phosphate aminotransferase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 2.6.1.9</html:p>
<html:p>COFACTOR: _2__45__KETOGLUTARATE</html:p>
<html:p>COFACTOR: GLT</html:p>
<html:p>SIDE: _2__45__KETOGLUTARATE</html:p>
<html:p>SIDE: GLT</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="IMIDAZOLE__45__ACETOL__45__P" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="L__45__HISTIDINOL__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="RXN0__45__2023" name="NA" reversible="true">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_097_mnmA ) or ( HCDSEM_097_2_mnmA ) or ( HCDSEM_097_3_mnmA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase ) or ( putative tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase ) or ( putative tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase )</html:p>
<html:p>SUBSYSTEM: NA</html:p>
<html:p>PROTEIN_CLASS: NA</html:p>
<html:p>COFACTOR: PPI</html:p>
<html:p>COFACTOR: ATP</html:p>
<html:p>COFACTOR: AMP</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="CYS" stoichiometry="1"/>
      <speciesReference species="URIDINE" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="_2__45__THIOURIDINE" stoichiometry="1"/>
      <speciesReference species="L__45__ALPHA__45__ALANINE" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="HISTCYCLOHYD__45__RXN" name="Phosphoribosyl-AMP cyclohydrolase" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_049_2 ) or ( HCDSEM_049 )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative phosphoribosyl-AMP cyclohydrolase ) or ( putative phosphoribosyl-AMP cyclohydrolase )</html:p>
<html:p>SUBSYSTEM: histidine biosynthesis</html:p>
<html:p>PROTEIN_CLASS: 3.5.4.19</html:p>
<html:p>SIDE: WATER</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="PHOSPHORIBOSYL__45__AMP" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="PHOSPHORIBOSYL__45__FORMIMINO__45__AICAR__45__P" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
  <reaction id="UROPORIIIMETHYLTRANSA__45__RXN" name="NA" reversible="false">
<notes>
<html:p>GENE_ASSOCIATION: ( HCDSEM_013_2_cobA ) or ( HCDSEM_013_cobA ) or ( HCDSEM_013_3_cobA )</html:p>
<html:p>PROTEIN_ASSOCIATION: ( putative uroporphyrin-III c-methyltransferase ) or ( putative uroporphyrin-III c-methyltransferase ) or ( putative uroporphyrin-III c-methyltransferase )</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis II (late cobalt incorporation)</html:p>
<html:p>SUBSYSTEM: siroheme biosynthesis</html:p>
<html:p>SUBSYSTEM: adenosylcobalamin biosynthesis I (early cobalt insertion)</html:p>
<html:p>PROTEIN_CLASS: 2.1.1.107</html:p>
<html:p>COFACTOR: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>COFACTOR: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>SIDE: PROTON</html:p>
<html:p>SIDE: ADENOSYL__45__HOMO__45__CYS</html:p>
<html:p>SIDE: S__45__ADENOSYLMETHIONINE</html:p>
<html:p>GENERIC: false</html:p>
<html:p>TYPE: small</html:p>
<html:p>HOLE: false</html:p>
</notes>
    <listOfReactants>
      <speciesReference species="UROPORPHYRINOGEN__45__III" stoichiometry="1"/>
    </listOfReactants>
    <listOfProducts>
      <speciesReference species="CPD__45__9038" stoichiometry="1"/>
    </listOfProducts>
  </reaction>
</listOfReactions>
</model>
</sbml>
